Integrated transcriptome and proteome analysis builds a molecular map of postnatal human cortical development

Our knowledge of the molecular factors that guide healthy cortical development is currently based on results from transcriptome analyses. However, one of the most challenging, yet intriguing, aspects yet to be characterized is how proteins express, function and interact across postnatal development. We surveyed the proteomic landscape of 69 dorsolateral prefrontal cortex (DLPFC) samples across seven stages of postnatal life and integrated these data with paired transriptome data. To promote the exchange of this information, we created this interactive, searchable companion website. Here researchers can: 1) query any protein/gene symbol of interest to determine whether it is expressed and which developmental stage it is expressed; 2) determine whether a user defined list of proteins/genes is over-represented within our identified proteomic and transcriptomic gene modules; 3) download all corresponding proteomic and transcriptomic data.

Examples: DCLK1, QDPR