15q11.2 copy number variation syndrome WP4940 TUBGCP2 CYFIP1 TUBGCP3 TUBGCP5 FMR1 TUBGCP6 NIPA2 NIPA1 TUBGCP4 15q13.3 copy number variation syndrome WP4942 KAT2B OTUD7A GOLGA8O CCL5 GOLGA8H LOC101929970 FANCD2 GOLGA8R MTMR10 CHRNA7 SERPINH1 FYN GPR75 CREBBP KLF13 CHRFAM7A FAN1 GRM6 TRPM1 16p11.2 distal deletion syndrome WP4950 TRAF2 MPL NFATC2 CR2 TUFM TRAF1 JAK2 RABEP2 NFATC2IP GRB2 CD19 RABGEF1 CD81 CD82 LAT C3 PLN KDR VAV2 SLN ATXN2L PRMT1 ATP2A1 SH2B1 SDCCAG8 SPNS1 IL4 INSR RAB4A RAB5A IFITM1 16p11.2 proximal deletion syndrome WP4949 TAOK2 CCT6A LOC105369277 TCP1 SIAH1 CCT3 IGFBP3 SEZ6L2 C16orf92 PPP4R3B IGBP1 CCT6B NR3C1 UNC13B CCT7 DOC2A CCT8 CCT2 CCT4 KIF22 PCNA CORO1A MAPK3 PRRT2 HIRA PAGR1 CASP8 PPP4R4 PPARG TBX6 PPP4R1 CDIPT PAXIP1 MAZ MVP TRAF2 NFKB1 TRAF6 SPN HIRIP3 ZG16 ESR1 UNC13A GDPD3 CCDC6 PPP4R2 TMEM219 PPP2CA PPP2CB PPP2R1A EZR CCT5 TP53 PPP4C HDAC3 QPRT YPEL3 BPTF KMT2D PARP4 FAM57B PTEN MAP2K6 PPP4R3A INO80E KCTD13 ALDOA ASPHD1 C16orf54 MSN REL PPP2R5D KMT2C MAP2K3 1q21.1 copy number variation syndrome WP4905 F11R PYGO2 OCLN PRKAA1 PRKAA2 PRKAB1 PRKAB2 NBPF12 FMO5 TJP1 GJA5 GJA3 KIRREL1 CTNNB1 AFDN PRKAG2 ACP6 GJA8 PRKAG1 TJP2 CHD1L PYGO1 AMELX GJA1 PRKAG3 TJP3 BCL9 22q11.2 copy number variation syndrome WP4657 SNAP29 HAND2 NPRL3 HIST2H4A BCL2 FOXC2 THAP7 SHH CDC42 SEPT5 CHRD RBX1 MALT1 TANGO2 DGCR2 VWF TSSK2 POLR2A CYP26A1 HIRA CLDN1 AIFM3 RCC1 SEPT8 DGCR8 ALDH4A1 ARNTL C22orf39 SLC2A4 PITX2 RORC SHOC2 P2RX6 ZDHHC8 ASF1A FOXC1 NKX2-5 MRPL40 KLHL22 CCDC188 UFD1 PI4KA HDAC3 ARVCF CLDN3 SEPT11 CDC45 TSKS ZNF74 TBX1 CYP26B1 NPRL2 HES1 SCARF2 CUL3 CLDN5 MAG LZTR1 ALDH1A2 RTN4 HIST1H4I GLUD1 KPNB1 CDH15 DROSHA XPO1 SLC7A4 PAK4 DRD2 FOXA2 ESS2 PAX3 ACTA2 SREBF1 SERPIND1 PRKN RTL10 RANGAP1 PPP1CB PLK1 TNPO1 CLTCL1 HIST4H4 TXNRD2 PRODH RAN RANBP1 EMC10 GBX2 HIRIP3 HIST1H4A SLC25A1 FGF8 DEPDC5 CBX5 COMT DGCR6L CRKL MED15 SRF SREBF2 ACTC1 GSC2 OAT CYP26C1 EGFR HIST1H4H HIST1H4B HIST1H4J HIST1H4C RTN4R TP53 HIST1H4E RAF1 NCOR1 HIST1H4L FGFR2 LRRC74B HIST1H4F HIST1H4K FGFR1 HIST1H4D GP1BB GP1BA GNB1L HIST2H4B TRMT2A FGF10 GP9 RELN GP5 3q29 copy number variation syndrome WP4906 RNF8 WDR34 MAD2L1BP DYNLT3 DYNLT1 DYNLL1 NF2 NCBP2 SLC51B SLC40A1 TGFB1 PAK2 MYC SENP5 TM4SF19 FNDC8 NCBP1 DYNC2H1 DLG1 CEP350 HIF1A UBE2N NRROS PIGM SIRT1 FBXW7 PXN UBXN7 BRINP1 CASP7 PIGZ AKT1 PIGX RABL2B FGFR1OP JUN ZDHHC19 WDR53 GRIA1 DYNLRB2 SMCO1 DYNLRB1 CEP19 TF PIK3R3 DYNLL2 TCTEX1D2 DYNC2LI1 RNF168 PCYT1A MELTF TFRC SLC51A FBXO45 HFE WDR60 ADAM10 MYCBP2 HAMP STAT5B STAT5A ZNF76 MCRS1 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression WP3879 MAP3K11 MAPK1 PRKAA1 MAPK3 RAF1 TSC1 PBK MAP2K6 MKNK2 MTOR AKT1 MKNK1 MAP3K5 MAP2K1 MAP2K2 EIF4EBP1 EIF4E MAP2K3 7-oxo-C and 7beta-HC pathways WP5064 CYP7A1 EPHX2 AMACR BAAT SLC27A5 SLC27A2 NPC1 DHCR7 ACOX2 NPC2 HSD11B2 HSD11B1 SCP2 ACOT6 ACOT1 ACOT12 ACOT11 CYP27A1 ACOT9 ACOT2 ACOT4 EBP ACOT13 ACOT7 THEM5 DBP ACOT8 7q11.23 copy number variation syndrome WP4932 DDX21 UBE2E1 NRG1 MLXIPL FAS MYC CLTC ATP5F1D VPS37C ATP5F1E ATP5PB ATP5MC1 HDAC6 ATPAF2 ATP5MC2 ATP5MC3 DLD ULK1 OGDH TBL2 CLASP1 CLDN1 CFL1 DLST SF3B1 DNAJC30 LAT2 CLIP2 UBE2L6 BECN1 BUD23 CHTF18 GRIP1 MYBBP1A ATP6 ATP8 FBLN5 ATP5F1A H2AFX FBN1 PKLR EIF4H ATP5PO UBE2E3 GTF2I VPS37A ACACA STX1A ACACB WNT2 FZD9 MYO1C HDAC3 HSPA2 CLDN3 CLDN4 CLDN5 TMEM270 RFC2 FBLN2 CLASP2 ATPAF1 ERCC6 VPS28 CTNNB1 HMGA1 TRIM50 DEK VPS37D PRKG1 MVB12A MAPK3 PCNA FKBP6 METTL27 SMARCA5 EIF2A BCL7B TSG101 UBIAD1 BAZ1B CDKN1C VPS37B GAPDH RFC5 GTF2IRD1 HDAC2 BTK ELN GRB2 ABHD11 VAMP2 NUP62 BRD4 USF1 EIF2AK3 ATF4 HOXC8 VPS9D1 LIMK1 ATP5F1B SQSTM1 SNAP25 RB1 ACE Inhibitor Pathway WP554 MAS1 REN TGFB1 ACE2 AGT AGTR1 AGTR2 KNG1 CMA1 CTSG CYP11B2 BDKRB1 BDKRB2 NR3C2 NOS3 ACE ATP6AP2 Acetylcholine Synthesis WP528 PCYT1A CHAT PEMT PDHA1 PDHA2 ACHE CHKA Activation of NLRP3 Inflammasome by SARS-CoV-2 WP4876 TRAF3 NFKB1 RELA IL1B PYCARD CASP1 NLRP3 Acute viral myocarditis WP4298 SOCS1 TNF ITGAL CREB1 PYCARD TGFB1 JAK1 AIF1 CCND1 IL2 BCL2 BCL2L1 CASP1 NOS1 CASP2 BID CASP3 CD40LG CASP6 JKAMP TLR4 TLR3 MAPK1 SGCB MAPK3 SGCA SGCG SGCD CXCR4 NOD2 IL6 CASP7 EIF4G2 CASP8 CAAP1 CASP9 EIF4G1 CD4 EDN1 AKT1 ACTB CYCS ITGB2 SRC RAC2 ABL1 NFKB2 TLR5 RAC3 STAT1 ABL2 SOS1 STAT3 TICAM1 DMD DFFB IFNG DFFA ILK CCR5 PTCRA CCR3 CAV1 MYH6 KRT8 PIK3R1 MICA PABPC1 ENDOG IL12B IL12A BAX PARP1 CXADR GSK3B HLA-DMA FYN BNIP2 LAMA2 CD80 IL10 CHRAC1 RASA1 DAG1 MMP9 CD55 Adipogenesis WP236 SOCS1 NDN EPAS1 TGFB1 AHR DVL1 FAS FOXC2 CELF1 IGF1 GDF10 PPARGC1A NCOA1 INS CISD1 MEF2A RBL1 NCOA2 BORCS8-MEF2B RBL2 NAMPT MEF2C FOXO1 MEF2D HIF1A IRS2 DLK1 CYP26A1 TWIST1 PLIN2 LPIN1 BMP1 SLC2A4 E2F1 GADD45B ZMPSTE24 RXRA STAT2 STAT1 RXRG STAT3 RORA BMP2 HNF1A BMP3 GH1 BMP4 E2F4 TRIB3 EBF1 FZD1 SERPINE1 SMAD3 NRIP1 LMNA ADIPOQ LPIN3 UCP1 WNT1 GTF3A STAT5B STAT5A RETN MIXL1 STAT6 CYP26B1 IRS1 DDIT3 GADD45A LPIN2 TNF PTGIS PPARA CREB1 WNT10B SOCS3 GATA3 PRLR GATA2 CTNNB1 ASIP HMGA1 ID3 NR3C1 SP1 SFRP4 LEP KLF7 GATA4 NR1H3 LPL SREBF1 IL6ST CNTFR IL6 CDKN1A KLF5 PPARD PLIN1 PPARG PCK1 PCK2 SCD MBNL1 SPOCK1 NR2F1 KLF15 PNPLA3 IRS4 KLF6 CFD FRZB EGR2 LIF LIFR RARA AGPAT2 MIF WWTR1 NCOR2 LIPE NCOR1 CEBPD CEBPB AGT CEBPA BSCL2 WNT5B OSM RB1 Aflatoxin B1 metabolism WP699 AKR7A2 GSTM1 AKR7A3 CYP1A2 CYP3A4 CYP2A13 EPHX1 AGE/RAGE pathway WP2324 PRKCD LGALS3 JAK2 DDOST CDC42 SP1 INS MMP14 PRKCA PRKCB CASP3 NOS2 FOXO1 NOS3 HIF1A MAPK1 MAPK3 PRKCZ CHUK CASP8 IRAK4 CASP9 ATF2 ALPL AKT1 INSR CYCS SRC MYD88 JUN NFKB1 TIRAP NFKBIA STAT1 PLA2G4A STAT3 ROCK1 AGER MAPK14 MAPK8 FOXO4 SOD1 RAC1 EGFR MSR1 SMAD2 EZR SMAD3 RELA SHC1 RAF1 MMP13 IKBKB INHBB RHOA NCF1 STAT5B MSN STAT5A MMP2 MAPK9 DIAPH1 IRS1 MMP7 MAP2K1 MMP9 Airway smooth muscle cell contraction WP4962 ROCK2 IL13 PLCB1 ROCK1 RYR1 PPP1R14A ADRB2 RHOA GNAQ GDI1 CD38 PPP1CB MYL1 CALM1 ITPR3 CALM2 MYLK Alanine and aspartate metabolism WP106 AGXT ASPA GPT ASS1 ASL ABAT GAD2 GAD1 GOT2 PC GOT1 DARS Allograft Rejection WP2328 TNF GABPA GZMB HLA-DRB1 HLA-DRA TGFB1 CSNK2A2 GDNF IL2RA HLA-DQB1 IL2 HLA-DQA2 FAS HLA-DQA1 FASLG HLA-DPB1 IL1B HLA-DPA1 C1QA C1QB TUBA1B C1QC CASP3 CD40 CD40LG C2 GNLY C3 CCL19 CCL21 PRF1 PDGFRA HLA-F HLA-E PRKCZ IL5 CASP7 HLA-DRB5 CXCR5 C4A CASP8 LRRK2 IL4 C4B CASP9 C5 C6 IL17A CXCL11 VEGFA ABCB1 STAT1 IL21 BHMT2 IFNG C7 C8A CXCL8 C8B HLA-G PECR C9 CXCL9 IL22 VIM CXCL12 MICA HARS IL1A IL13 HLA-DOB HLA-DOA CTLA4 IL12B IL12A AGTR1 HLA-DMB HLA-DMA HLA-C HLA-B HLA-A COL5A1 CD28 CD80 IL10 CD86 CXCL13 FOXP3 CD55 Alpha 6 Beta 4 signaling pathway WP244 PRKCD PTPN11 SOS1 HRAS LAMB2 LAMB3 LAMC1 GRB2 MAPK14 LAMC2 LAMA1 PRKCA ITGA6 RAC1 EIF4EBP1 LAMA5 GAB1 LAMB1 PIK3R1 IRS2 PIK3R2 ITGB4 MAPK1 MAPK3 SHC1 RHOA LAMA2 MTOR LAMA3 AKT1 IRS1 PTK2 SRC Alzheimer's disease WP2059 FADD PSEN1 PSEN2 APP FAS PPP3CC PPP3R1 SNCA BID PPP3R2 NOS1 ADAM17 CALML5 ATF6 CHPF2 ATP5MD ATP2A1 ATP2A2 ATP2A3 PSENEN CALM1 CALM2 CALM3 IDE CACNA1C CACNA1D NCSTN CALML3 CACNA1F CACNA1S RYR3 PLCB2 PLCB3 PLCB4 CHP2 HSD17B10 ITPR1 ITPR2 CAPN1 CAPN2 CHP1 TNF CDK5R1 CDK5 IL1B APAF1 GRIN2D CASP3 GRIN2C ITPR3 GRIN2B GRIN2A GRIN1 TNFRSF1A ERN1 MAPK1 MAPK3 LPL APBB1 CASP7 CASP8 GAPDH CASP9 MAPT CYCS LRP1 MME BACE1 BAD AGER VMP1 APH1A CASP12 NAE1 PPP3CA TP53 PPP3CB PLCB1 EIF2AK3 GSK3B ADAM10 GNAQ APOE Amino Acid Metabolism Pathway Excerpt (Histidine catabolism extension) WP4661 GLUD1 AMDHD1 HAL UROC1 GPT2 FTCD Amino Acid metabolism WP3925 TPH1 ACLY P4HA2 PDHX FH CAD GLUD1 GLS HIBCH CBS HMGCS2 MARS2 BHMT SUCLG1 MAOA FARSB ACO2 DLD OGDH TH WARS IARS HNMT GPT2 TPO ASNS DLST DBH ASS1 ADH1C GLUL ADH4 ADH5 PCK1 TDO2 HIBADH VARS PDK4 MUT HDC MDH1 MDH2 PDHA1 ADH7 IDH1 RARS LDHA CS ALDH1A1 PPM1L PYCR1 PKM ALDH18A1 GOT2 OAT SRM GOT1 ACAA1 SDS ACADM SDHA HAL HMGCL CPS1 HADH PC FAH CTH ARG1 ARG2 PNMT DDC EHHADH BCAT1 GCLM ACSS1 EPRS LARS2 ALDH7A1 TAT SMS G6PC2 MPST AUH ODC1 GSS MCCC1 OTC GSR AOC3 FTCD AMP-activated protein kinase (AMPK) signaling WP1403 LOC101930123 RPS6KB2 CAB39 RPS6KB1 STK11 TSC1 EEF2K FASN SLC2A4RG CPT1C CPT1B EEF2 LEP LEPR BORCS8-MEF2B EIF4EBP1 SREBF1 STRADA ADIPOR1 HNF4A GYS2 GYS1 CDKN1A PRKAG3 ADIPOR2 MTOR TSC2 AKT1 AKT2 INSR SLC2A4 PPARGC1B PRKAA1 PRKAA2 PIK3C3 PRKAB1 PRKAB2 INS-IGF2 CCNA2 CCNB1 ELAVL1 RPTOR PRKAG2 PIK3R3 CCNA1 ACACA ACACB PIK3CG PIK3R1 PRKAG1 PIK3R2 TP53 LIPE HMGCR CPT1A ADIPOQ PIK3CA PLCB1 PIK3CB PIK3CD CRTC2 CAMKK2 ADRA1B ADRA1A CAMKK1 PRKACB PRKACG STRADB PFKFB3 Amplification and Expansion of Oncogenic Pathways as Metastatic Traits WP3678 PIK3CG WNT2 CYTIP VEGFA VCAM1 CXCR4 EPAS1 JAG1 TNC TCF7L1 LEF1 NOTCH1 VHL TCF7 POSTN SRC TCF7L2 Amyotrophic lateral sclerosis (ALS) WP2447 TNF GRIA1 BAD BCL2 DERL1 BCL2L1 MAPK14 NEFM PPP3CC APAF1 CASP1 NOS1 BID SOD1 NEFH CASP3 TOMM40 SLC1A2 RAC1 DAXX NEFL CASP12 TNFRSF1A PPP3CA TP53 CCS PRPH PPP3CB CST3 BAX MAP2K6 ALS2 GPX1 CASP9 CAT MAP3K5 RAB5A MAP2K2 Androgen receptor signaling pathway WP138 KAT2B PLPP1 CREB1 EP300 FHL2 SIN3A PIAS2 TGFB1I1 BRCA1 CCND1 KLK3 CTNNB1 CDC42 SP1 NCOA1 KAT7 NCOA2 CARM1 DAXX FOXO1 ROCK2 RNF4 RNF6 SIRT1 EFCAB6 ZNF318 TGIF1 ETV5 AES FLNA AR CDKN1A CREBBP DSTN AKT1 UBE2I BMF PTK2 SRC RAN PARK7 JUN SUMO1 NR0B2 RLN1 RAD9A PIAS1 STUB1 STAT3 HDAC1 NCOA4 KDM1A NR2C2 ROCK1 MDM2 BAG1 FKBP4 CCNE1 PIAS4 CALR UBE3A CAV1 SMARCE1 RAC1 RACK1 EGFR PRDX1 PIK3R1 PIK3R2 NCOR2 SMAD3 SMAD4 RELA NCOA3 NCOR1 PATZ1 PSMC3IP PTEN GSK3B KAT5 RHOA RUNX2 RHOB ZMIZ1 LIMK2 RNF14 BUB1B-PAK6 PAK6 PIAS3 RB1 Angiogenesis WP1539 TIMP2 TEK SMAD1 HIF1A MAPK1 TIMP3 PDGFB VEGFA KDR PDGFRA FGFR2 PIK3CA ANGPT1 FGF2 MAPK14 CREBBP FLT1 PLCG1 ARNT AKT1 PTK2 SRC NOS3 MMP9 Angiopoietin Like Protein 8 Regulatory Pathway WP3915 RPS6KA3 MAP3K9 RPS6KA2 MAP3K10 RPS6KB2 RPS6KB1 MAP3K11 MAP4K1 MAP4K5 CYP7A1 MAP4K3 RPS6KA1 MAP3K6 MLXIPL DIO2 CYP3A4 INS FOXO3 EIF4EBP1 FOXO1 EIF4E SHC2 IRS2 MAP3K7 SLC2A1 MAP3K1 INSR MAP3K3 MAP3K4 SLC2A4 MAP3K5 FLOT2 THRB PIK3C2A THRA RXRA PRKAA1 PIK3C2G PRKAA2 PIK3C3 SOS1 PRKAB1 PRKAB2 EXOC7 RICTOR HRAS FBP1 RPTOR PRKAG2 RHEB PIK3CG PIK3R1 PIK3R2 ANGPTL8 PRKAG1 MLST8 MAPK12 RHOQ PIK3CA RPS6KA5 PIK3CB PDPK1 PIK3CD MAP2K5 MAP2K6 MAP2K7 SOS2 MAPK11 MAP2K4 MAPK9 MAPK10 IRS1 MAPK13 CAP1 MAP2K1 MAP2K2 MAP2K3 TSC1 FASN MAP3K14 FLOT1 ABCG8 ABCG5 MAPK1 NR1H3 MAPK3 LPL PIK3R4 MAPK4 RPS6KA4 MAP4K2 SREBF1 MAPK6 MAPK7 RPS6KA6 GYS1 MAP3K2 PRKAG3 MTOR MINK1 PCK1 TSC2 AKT1 SHC3 AKT2 SCD TRIP10 SLCO1C1 MAP4K4 MAP3K12 IRS4 CBLC RAPGEF1 CYP2B6 MAPK14 SESN3 CRK MAPK8 SREBF2 SLC16A2 PIK3R3 PTPN1 SHC1 RAF1 MAP3K13 GSK3B MAP3K8 GSK3A MAPKAP1 CBL CBLB G6PC ApoE and miR-146 in inflammation and atherosclerosis WP3926 TLR4 TRAF6 NFKB2 RELA APOE SPI1 IRAK1 TLR2 Apoptosis Modulation and Signaling WP1772 FADD TNFRSF6B PTPN13 PRKD1 FOS MCL1 MAP3K14 BCL2L11 BCL2 BCL2A1 TOLLIP FAS FASLG BCL2L1 BCL2L2 IL1R1 PIDD1 APAF1 CASP1 CASP2 SEPT4 BID AIFM2 CASP3 BIK CASP4 DAXX CASP6 BCL2L10 DIABLO TNFRSF1A TNFRSF1B MAPK3 TNFSF10 IL1R2 TNFRSF11B CDKN2A BLK BIRC7 CASP7 CASP8 CASP9 PTRH2 CASP10 RIPK1 BIRC2 CYCS BMF MAP3K5 MYD88 CRADD JUN HRK TRAF3 TNFRSF10C TNFRSF10B TRAF6 NFKB1 TNFRSF10D NFKBIA NAIP PMAIP1 TNFRSF10A HTRA2 BIRC3 BAD XIAP BIRC5 BIRC6 DFFB DFFA BAK1 MAPK8 IRAK1 BAG3 PEA15 MADD TP53 IKBKB ENDOG AIFM1 BAX HSPA1A BNIP3 BBC3 BOK TNFRSF25 CAPNS1 CFLAR TRADD Apoptosis Modulation by HSP70 WP384 FADD TNFRSF1A NFKB1 AIFM1 FAS CASP7 HSPA1A FASLG CASP8 CASP9 MAP3K1 APAF1 RIPK1 BID CASP2 CASP3 CYCS MAPK10 CASP6 Apoptosis WP254 FADD TNF GZMB TP73 IGF2 IGF1R MCL1 TNFRSF21 BCL2L11 BCL2 FAS MYC IGF1 BCL2L1 FASLG BCL2L2 CASP1 LTA APAF1 BID CASP2 CASP3 CASP4 DIABLO CASP6 TNFRSF1A TNFRSF1B PRF1 TNFSF10 CDKN2A CHUK CASP7 CASP8 CASP9 CASP10 AKT1 RIPK1 MAP3K1 BIRC2 CYCS CRADD HRK JUN TRAF3 SCAF11 TRAF2 TNFRSF10B NFKB1 NFKBIA IRF2 NFKBIB PMAIP1 IRF3 NFKBIE IRF4 TRAF1 MDM2 BAD BIRC3 XIAP BIRC5 DFFB DFFA BAK1 TP63 IRF1 PIK3R1 HELLS RELA TP53 IKBKB BAX BBC3 BNIP3L BOK IRF5 IRF6 IKBKG IRF7 MAP2K4 MAPK10 TNFRSF25 CFLAR TRADD Apoptosis-related network due to altered Notch3 in ovarian cancer WP2864 CUL1 YBX3 RPS6KB1 TNF PKN1 CARD14 SOCS3 SMAD7 NRG1 APP PAK2 TNFRSF21 HSPB1 F2R RNF7 VAV3 RIPK2 ERN1 THBS1 MAPK1 BEX3 CUL5 HSPD1 JUND CDKN1B CDKN1A CASP7 ETS1 BCL3 AKT1 PTK2 TNFRSF10B NFKB1 IER3 ABL1 AXIN1 HDAC1 TRAF1 BIRC5 SERBP1 IL7R NET1 GCLC HELLS VIM CTNNA1 ERBB3 PTK2B APOE SQSTM1 ANXA5 NQO1 HSPA5 Arachidonate Epoxygenase / Epoxide Hydrolase WP678 COX5A CYP2C8 GSTP1 CYP2J2 COX8A EPHX2 CYP2C9 Arrhythmogenic Right Ventricular Cardiomyopathy WP2118 ACTN2 ACTN3 ITGA9 CACNG8 CACNG6 CACNG7 TCF7L1 CTNNB1 CTNNA2 SLC8A1 ITGA2B ITGA3 ITGA4 ITGA5 ITGA7 ITGA11 ITGB3 ITGB4 SGCB ITGB5 SGCA ITGB6 SGCG ITGB7 SGCD CACNA2D4 CTNNA3 JUP ATP2A2 LEF1 ITGAV DSG2 CACNG5 ACTB ITGB1 DSC2 CACNG4 CDH2 EMD DMD DSP CACNA1C DES CACNA1D ITGB8 CACNA1F CACNA1S ACTG1 ITGA6 PKP2 RYR2 CACNA2D2 LMNA ITGA1 ITGA2 CTNNA1 CACNA2D1 CACNB1 CACNB2 CACNB3 CACNB4 CACNA2D3 CACNG1 GJA1 LAMA2 ITGA8 ACTN4 TCF7 ITGA10 TCF7L2 DAG1 CACNG2 ACTN1 CACNG3 Aryl Hydrocarbon Receptor Netpath WP2586 NFKB1 VEGFA CDC37 TNF AIP NRAS HSP90AA1 ESR1 EP300 HRAS AHR HPGDS KLF6 CDK2 MYC PSRC1 NF1 NCOA7 GCLC EGFR RET FGF21 NFE2L2 MAPK1 NRIP1 NCOR2 RELA LPL CCL1 RAF1 AHRR CYP1B1 CDKN1B CYP1A2 CYP1A1 CDKN1A ARNT PLAGL1 PTGS2 NQO1 SRC MAP2K1 CD36 E2F1 KRAS RB1 Aryl Hydrocarbon Receptor Pathway WP2873 HES1 CDC37 TNF AIP EP300 HSP90AA1 IGFBP1 TGFB1 AHR IL2 IFNG UGT1A6 UGT1A7 IL1B NCOA1 UGT1A3 UGT1A1 ALDH3A1 UGT1A4 POLK EGFR MYOF SERPINB2 NFE2L2 IL12B IL12A AHRR BAX SLC7A5 JUNB JUND CYP1B1 CES3 CDKN1B CYP1A2 UGT1A9 CYP1A1 PTGES3 MGST1 ARNT IL17B CAP2 GSTA2 NQO1 SRC JUN Arylamine metabolism WP694 SULT1A1 CYP1A2 UGT1A9 SULT1A2 UGT1A4 NAT2 Aspirin and miRNAs WP4707 PDK1 NFKB1 VEGFA PPARA MVD WNT1 PTGS1 PTGS2 ABCC4 NOS3 Association Between Physico-Chemical Features and Toxicity Associated Pathways WP3680 NCK1 ACTR2 ACTR3 DAAM1 WNT11 DVL1 MYC CTNNB1 PLCG1 NOS1 PFN1 PFN2 PFN3 ACTA1 ROCK2 MAPK1 PFN4 GPX1 CDKN1B CDKN1A APC AKT1 CAMK1 PTK2 SRC JUN SOS1 AXIN1 GRIA1 WNT16 GRB2 ELK1 NEFM MAPK8 FZD3 FZD5 SOD1 NEFH PPP2CA NEFL EGFR FZD1 PIK3CG FZD4 TMSB4X FZD8 SHC1 FZD9 RAF1 PAK1 TGFA FZD6 FZD7 ERBB4 ERBB2 GSK3B RHOA FZD2 FN1 CBL STAT5A MYL1 MAP2K4 FZD10 MAP2K1 MYLK ATM Signaling Network in Development and Disease WP3878 RNF8 NFKB1 PRKAA1 STK11 CDK5R1 ATMIN CDK5 PPM1D ATM RIF1 HSPB1 RNF20 BUB1 CHEK1 H2AFX HDAC4 TRIM28 PPP5C CHEK2 RAD50 LBR RBBP8 RNF168 PRKDC AURKB MRE11 SMC1A DCLRE1C MDC1 TP53BP1 RNF40 NBN HMGN1 KAT5 CEP63 CDK1 ATR ATF2 MTOR IKBKG TSC2 PTPA MAP3K5 RASGRF1 G6PD ATM Signaling Pathway WP2516 MDM4 ABL1 NFKBIA RAD9A CREB1 FANCD2 TP73 ATM MDM2 CCNB1 BRCA1 CDK2 CDC25A CDC25C H2AFX PIDD1 CCNE1 CHEK1 CASP2 BID CHEK2 RAD50 MRE11 SMC1A MDC1 TP53BP1 TP53 NBN TLK1 AP3B2 CDKN1A CDK1 ATF2 IKBKG RIPK1 MAPK9 RAD51 CRADD GADD45A JUN ATR Signaling WP3875 ATRIP TOPBP1 RAD9A ATR CHEK1 RAD9B RPA1 HUS1 RAD1 Autophagy WP4923 PRKAA1 RB1CC1 PRKAA2 BECN1 PIK3C3 PRKAB1 PRKAB2 DEPTOR ATG12 RPTOR MAP1LC3B ATG101 AMBRA1 PRKAG2 ULK1 ATG7 PRKAG1 ATG5 MLST8 PIK3R4 ATG3 ATG13 ATG16L1 ATG9A ATG14 AKT1S1 WIPI2 PRKAG3 MTOR UVRAG Autosomal recessive Osteopetrosis pathways WP4788 TRAF6 NFKB1 TNFRSF11A TNFSF11 PLEKHM1 IKBKB CLCN7 SNX10 OSTM1 RAB7A TCIRG1 B Cell Receptor Signaling Pathway WP23 NCK1 PTPN11 MAP4K1 RPS6KA1 MYC CDC42 PTPN6 MALT1 INPP5D MEF2C FOXO1 MEF2D GAB1 LYN MAP3K7 BLK PIK3AP1 CARD11 PTPRC LAT2 SOS1 IRF4 HRAS PIP5K1A PIP5K1B BLNK E2F3 CD19 CD22 CAMK2A LCK GTF2I PIK3CG PIK3R1 PIK3R2 RELA IKBKB PDPK1 MAP2K6 PIP5K1C MAPK9 REL MAP2K1 MAP2K2 DAPP1 PRKCD TEC NFATC2 CREB1 CR2 BRAF RASGRP3 PLCG1 PLCG2 PRKCB KLF11 MAPK1 VAV2 MAPK4 CHUK ETS1 ATF2 NFATC3 AKT1 BCL6 ILF2 VAV1 JUN NFKB1 SH3BP2 RAC2 SYK NFKBIA RAPGEF1 BTK GRB2 MAPK14 CD79A CRKL HCLS1 CD79B CRK ELK1 CD81 MAPK8 MAX RAC1 SHC1 RAF1 PTPN18 GSK3B GSK3A FYN IKBKG CBL GAB2 BCL10 Base Excision Repair WP4752 MPG MBD4 MUTYH LIG3 PNKP POLE4 POLD3 APEX2 NEIL3 SMUG1 POLL NEIL2 XRCC1 POLD4 OGG1 LIG1 PARP2 UNG PCNA PARP1 FEN1 HMGB1 POLB APEX1 TDG POLD1 POLD2 POLE3 POLE POLE2 NTHL1 BDNF-TrkB Signaling WP3676 TRPC3 LOC101930123 RPS6KB1 SOS1 TSC1 NRAS TRPC6 CREB1 HRAS EEF2K RPS6KA1 BRAF GRB2 PLCG1 RHEB MKNK1 EIF4EBP1 GRIN1 GAB1 PIK3CG MAPK1 SHC1 HOMER1 ARC NTRK2 DLG4 MTOR ADCY1 AKT1 TSC2 BDNF GAB2 MAP2K1 KRAS Benzene metabolism WP3891 GSTM1 DHDH MPO CYP2E1 NQO1 EPHX1 Benzo(a)pyrene metabolism WP696 AKR1C2 AKR1A1 AKR1C1 CYP1B1 CYP3A4 AKR1C3 CYP1A1 EPHX1 AKR1C4 Bile acids synthesis and enterohepatic circulation WP4389 ABCG8 ABCG5 MAPK1 MAPK3 FGF19 SLC10A2 SLC10A1 FGFR4 CYP7A1 FXR1 LDLR ABCB11 Biogenic Amine Synthesis WP550 TH PAH TPH1 AANAT GAD2 HDC GAD1 PNMT DDC DBH COMT CHAT ASMT MAOA ACHE Biomarkers for pyrimidine metabolism disorders WP4584 RRM2 RRM1 TYMS TYMP CKB TK2 UMPS DHODH NT5C3A RRM2B PUS1 DPYS DPYD UPB1 NT5C Biomarkers for urea cycle disorders WP4583 NAGS GLS2 GPT F10 ASS1 ASL F7 GAMT GOT1 OTC GATM ARG1 Biotin Metabolism (including IEMs) WP5031 MCCC2 PCCB BTD PC MCCC1 HLCS ACACA ACACB PCCA Bladder cancer WP2828 DAPK2 VEGFA RASSF1 NRAS HRAS UPK3A MDM2 DAPK3 CDK4 DAPK1 CCND1 BRAF MYC EGF CXCL8 CDH1 HBEGF EGFR PIK3R1 THBS1 PIK3R2 MAPK1 TP53 RAF1 TYMP ERBB2 FGFR3 RPS6KA5 CDKN2A CDKN1A ARAF MMP1 MMP2 E2F1 SRC MAP2K1 KRAS MMP9 MAP2K2 RB1 Blood Clotting Cascade WP272 VWF PLG SERPINE1 SERPINB2 SERPINF2 F7 FGA F13B F5 F3 F12 F8A1 F11 KLK1 F10 KLKB1 F9 F2 F8 FGG FGB PLAT PLAU BMP Signaling Pathway in Eyelid Development WP3927 SMAD1 MAPK3 SMAD4 TGFA SFRP1 FGFR2 FOXC1 SMAD5 INHBB BMP4 FOXC2 FGF10 DKK2 SHH NOTCH1 MAP3K1 MAPK9 PITX2 EGFR JUN BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation WP3876 DKK1 LEFTY2 SMAD1 SST SFRP1 SMAD5 WNT4 SMAD9 DCN BMP2 BCL2L11 CTNNB1 FOXO1 Bone morphogenic protein (BMP) signaling and regulation WP1425 BMP2 TOB2 SMAD1 RUNX2 SMAD4 TOB1 BMPR1A BMPR1B BMPR2 SMURF1 SMAD6 NOG Brain-derived neurotrophic factor (BDNF) signaling pathway WP2380 RPS6KA3 NCK1 EIF2S2 PTPN11 RPS6KB1 RPS6KA1 RPS6 BCL2L11 CSNK2A1 FRS3 CDC42 NCF2 SHC4 DLG1 MEF2A FOXO3 ADAM17 EIF4EBP1 MEF2C EIF4E SHC2 IRS2 PTPRF GABRB3 FRS2 CFL1 ALPL SIRPA MAP3K1 CAMK1 TRAF6 PRKAA1 PRKAA2 KCNN2 STAT1 STAT3 CDH2 HRAS GRIP1 YBX1 BMP2 NSF NTF3 CAMK4 CAMK2A ACACB PIK3R1 NCK2 PIK3R2 RELA IKBKB PTK2B RPS6KA5 PDPK1 MARCKS TIAM1 NTRK1 MAP2K5 NTRK2 NCF1 NTRK3 KIDINS220 SH2B1 STAT5B DPYSL2 STAT5A MAPK9 MAPK10 IRS1 IGF2BP1 MAP2K1 MAP2K2 PRKCD CDKL5 CDK5R1 CREB1 FOS CDK5 RHOG SORT1 NGFR JAK2 CTNNB1 VAV3 PLCG1 KSR1 EEF2 CASP3 GRIN2B GRIN1 NGF MAPK1 MAPK3 VAV2 MAPK7 RAP1A MAP3K2 CHUK CNR1 APC CRTC1 MTOR AKT1 TSC2 MAPT RAB3A SHC3 NFATC4 SRC DOK5 JUN NFKB1 NFKBIA SPP1 GRIA3 GRIA2 GRIA1 BAD KCNA3 GRB2 DOCK3 MAPK14 ELK1 MAPK8 EGR2 PPP2CA EGR1 RAC1 RACK1 SHC1 NCAM1 RAF1 CYFIP1 EIF2S1 GSK3B FYN SH2B2 IKBKG SYN1 LINGO1 SQSTM1 BDNF RANBP9 RASGRF1 Breast cancer pathway WP4262 RPS6KB2 RPS6KB1 CSNK2B CSNK1A1L FGF22 IGF1R ATM DVL1 CSNK2A2 CCND1 CSNK2A1 MYC IGF1 CSNK1A1 NCOA1 SHC4 DVL3 DVL2 SHC2 WNT4 CETN3 ARAF NOTCH1 NOTCH2 NOTCH3 FRAT1 FGF18 NOTCH4 E2F1 FGF20 GADD45B SOS1 AXIN1 AXIN2 HRAS KIT GADD45G WNT16 FLT4 CSNK2A3 E2F3 E2F2 FZD3 FZD5 FGF17 FGF16 RAD50 POLK FZD1 WNT3 PIK3R1 WNT2 MRE11 PIK3R2 WNT6 WNT5A TNFSF11 FZD8 WNT7B FZD9 WNT7A NCOA3 FZD6 FZD7 ESR2 ERBB2 PIK3CA WNT1 PARP1 PIK3CD PTEN DDB2 ATR AKT3 SOS2 TCF7 FZD10 TCF7L2 MAP2K1 MAP2K2 GADD45A HES1 NRAS FOS CDK6 FRAT2 WNT10B WNT2B WNT11 CDK4 BRCA1 BRAF TCF7L1 BRCA2 CTNNB1 WNT10A SP1 APC2 SFRP4 JAG2 MAPK1 MAPK3 HES5 DLL4 CDKN1A LEF1 HEY2 APC MTOR AKT1 SHC3 AKT2 KRAS JUN PGR NFKB2 FGF19 DLL1 FGF9 ESR1 FGF8 FGF7 FGF6 FGF5 FGF23 FGF4 FGF3 GRB2 EGF FGF2 FGF1 BAK1 HEY1 PIK3R3 EGFR FGF21 LRP6 HEYL LRP5 WNT3A TP53 SHC1 NBN SKP1 RAF1 FGFR1 BAX GSK3B FZD2 WNT5B FGF10 RAD51 DLL3 RB1 Calcium Regulation in the Cardiac Cell WP536 KCNJ3 RGS5 GNGT1 GNG11 GJA5 ADCY5 GJA4 GJA3 GNG7 ADCY6 GNG5 ADCY7 ADCY8 GNG4 ADCY9 GNG3 STIM2 GNB3 GJB4 GNB2 GNG13 GJB5 GJB3 GJB2 GJB1 GJA8 RGS10 GNG8 RGS7 RGS9 RGS16 RGS11 ATP1A4 ATP1B1 ATP1B2 FKBP1A ATP1B3 GNG12 FXYD2 ATP2A2 ATP2A3 KCNJ5 CALM1 RGS6 CAMK1 ARRB1 CALM2 ARRB2 CALM3 ATP2B1 ATP2B2 ATP2B3 GJD2 RGS14 CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CALR CACNA1S CAMK4 CAMK2A CAMK2B CAMK2D CAMK2G RYR3 RYR2 PKIB PLCB3 PRKAR1A RGS20 PRKAR1B PRKAR2A CHRM4 CHRM3 RYR1 CHRM2 CACNB1 CHRM1 ADRA1D CACNB3 ITPR1 GJB6 ADRA1B ADRA1A GJA1 ITPR2 PRKACA PRKACB PKIA ANXA6 PRKCD PRKCE PRKCG PRKCH PKIG GJC1 PRKD1 GRK6 ADRB1 ADRB2 ADRB3 CHRM5 SLC8A1 PRKAR2B PRKCA PRKCB ITPR3 SLC8A3 YWHAQ GRK5 GRK4 PLN YWHAG YWHAE YWHAZ YWHAH RGS18 PRKCZ CASQ1 PRKCQ CASQ2 YWHAB ADCY4 GNAI2 GNAI1 GJC2 GNG2 GNA11 GNB4 RGS17 RGS1 RGS2 RGS3 RGS4 GNB1 GNAZ GNAS SFN GNAQ GNAO1 GJA9 GNAI3 ADCY1 ADCY2 GNB5 ADCY3 RGS19 KCNB1 Caloric restriction and aging WP4191 IGF1 TP53 MTOR PRKAB2 PPARGC1A AKT1 SIRT1 NAMPT CAMKK2 Pathway WP4874 WFS1 TSC1 NFATC2 ARHGEF7 CREB1 EP300 ICAM1 HMOX1 MAF RPTOR FIS1 HDAC4 NOS1 CAMK4 DNM1L RAC1 SMC1A MAPK1 NFE2L2 MAPK3 RELA STIM1 RAF1 VCAM1 CHRM3 GIT1 SIRT1 CAMKK2 MAP1LC3A MTOR CALM1 CAMK1 SQSTM1 CALM2 Cancer immunotherapy by CTLA4 blockade WP4582 PIK3R1 PIK3R2 PTPN11 HLA-DRB1 CTLA4 PIK3CA PIK3CB PIK3CD CD28 CD80 CD86 PTPN6 PIK3R3 PPP2CA Cancer immunotherapy by PD-1 blockade WP4585 NFKB1 PTPN11 PDCD1 NFATC1 STAT3 NFATC2 HLA-DRB1 BATF NFAT5 IFNG HLA-A CD274 PDCD1LG2 ZAP70 NFATC3 NFATC4 CD8A CD3D LCK CD8B CD3E JUN CD3G Cannabinoid receptor signaling WP3869 NAPEPLD AHR CYP2C19 ADCY7 ADORA2A CYP3A4 MAPK14 MAPK8 PRKAR2B CYP2C9 DAGLB MAPK1 MAPK12 MAPK3 PRKAR1A PRKAR1B FAAH CNR2 CNR1 CYP1A1 PRKACA ADCY1 PRKACB MAPK11 MAPK9 PRKACG DAGLA MAPK10 MAPK13 Canonical and non-canonical Notch signaling WP3845 HES1 PSEN1 PSEN2 DLL1 DLK2 RBPJ HEY1 MAML2 DNER JAG2 MAML1 DLK1 JAG1 ADAM10 DLL4 CHUK LEF1 MAML3 CNTN6 NOTCH1 RRAS MFAP1 NOTCH2 MFAP2 NOTCH3 DLL3 NOTCH4 Canonical and non-canonical TGF-B signaling WP3874 TGFBR1 LOXL4 SMAD2 TGFBR2 SMAD3 SMAD4 TGFB1 MAPK14 GREM1 BMPR1A MAPK8 LOX LOXL1 BMPR2 MAPK9 LOXL2 BMP1 Canonical NF-KB pathway WP4562 NFKB1 NFKBIA CHUK RELA NFKBIE IKBKB IKBKG REL Cardiac Hypertrophic Response WP2795 TGFBR1 MAP4K1 TNF PRKD1 NFATC2 CDK7 TGFB1 NRG1 MAP3K14 IGF1 HDAC7 PRKCA MEF2A HDAC5 TNFRSF1A PRKG1 MAPK1 MAPK3 MAP3K7 MAPK7 CHUK CDK9 MTOR MAP3K1 CALM1 AKT1 AKT2 CALM2 IKBKE NFKB1 PLA2G2A EGF FGF2 MAPK14 MAPK8 HDAC4 RAC1 CAMK2D PPP3CA HDAC9 RAF1 IKBKB FGFR2 PDPK1 MAP2K5 MAP2K6 GSK3B MAP2K7 IKBKG MAP2K4 NPPA MAP2K1 MAP2K2 GUCA1A MAP2K3 Cardiac Progenitor Differentiation WP2406 POU5F1 TGFB1 IGF2 NRG1 IGF1 INS ROR2 MYLK3 MEF2C GATA4 FOXA2 SOX17 PDGFRA CXCR4 TNNI3 ZFP42 MESP1 NOTCH1 SIRPA NANOG LIN28A TBX5 BMP1 SCN5A IRX4 LIN28B ANPEP NKX2-5 PAX6 NOG KIT BMP4 FGF2 MAPK14 TNNT2 ACTC1 MYH6 DKK1 WNT3A KDR ISL1 NCAM1 TBXT THY1 GSK3B MESP2 NODAL INHBA TBX20 SOX1 MYL2 SOX2 MIXL1 Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs) WP688 FMO3 FMO2 FMO1 FMO5 FMO4 Cell cycle WP179 MCM3 MCM4 TGFB3 MCM5 MCM6 MCM7 MAD1L1 ANAPC4 EP300 SMC1B TGFB1 BUB3 TGFB2 MCM2 ATM CDC6 CDC20 CCND1 CCNB3 MYC CDC25A CDC25B CDC25C WEE2 CDC27 SKP2 RBX1 RBL1 RBL2 ANAPC11 PTTG1 ANAPC1 E2F1 GADD45B ANAPC13 ABL1 CDC14A WEE1 SMC3 CDC14B PKMYT1 CCNA2 MDM2 CCNB1 ANAPC2 E2F5 GADD45G CCND2 E2F4 CCND3 E2F3 CCNE1 CHEK1 E2F2 CHEK2 CCNB2 CCNE2 SMAD2 SMAD3 SMAD4 ATR DBF4 CDC45 ANAPC7 ANAPC5 CDC7 ORC1 ORC2 GADD45A CUL1 ESPL1 CDC23 CDK7 CDK6 MAD2L2 CDK4 CDK2 STAG2 YWHAQ PRKDC PCNA YWHAG YWHAE YWHAZ YWHAH CDKN2D CDKN2C CDKN2B CDKN2A PTTG2 CDKN1C CDKN1B CDKN1A PLK1 YWHAB ORC4 ORC5 ANAPC10 TFDP1 HDAC2 HDAC1 BUB1 FZR1 STAG1 CCNA1 SMC1A CDC16 TP53 SKP1 ORC3 TTK ZBTB17 GSK3B SFN CDK1 ORC6 RAD21 TFDP2 CCNH RB1 Cell Differentiation - Index expanded WP2023 LEFTY2 MEF2B EZH2 MEF2A HDAC5 MEF2C MEF2D KLF4 TLX3 MYOD1 STAT3 PAX7 LEFTY1 SRF ID2 TLX2 TLX1 RUNX2 SOX2 Cell Differentiation - Index WP2029 LEFTY2 STAT3 MEF2B LEFTY1 SRF MEF2A HDAC5 MEF2C MEF2D TLX2 TLX1 TLX3 MYOD1 Cell migration and invasion through p75NTR WP4561 TRIO STAT3 NGFR ARF1 RAC1 ADAMTS13 PAK1 TWIST1 TIAM1 EFNA2 EFNA1 NTRK2 RHOA PARD3 KIDINS220 AKT3 MMP2 AKT1 EFNB3 AKT2 EFNB2 BDNF EFNB1 MMP8 EFNA5 MMP9 EFNA4 EFNA3 JUN CDH11 Cell-type Dependent Selectivity of CCK2R Signaling WP3679 TRPC1 RYR3 RYR2 GNAI1 PLCB1 RYR1 GNAQ ITPR1 CNR1 CCK CD38 CCKBR DAGLA Cells and molecules involved in local acute inflammatory response WP4493 TNF ITGAL VCAM1 IL1A ICAM1 KNG1 IL6 C7 CXCL8 SELP ITGA4 SELPLG ITGB1 C5 ITGB2 C3 C6 Cellular Proteostasis WP4918 VBP1 PFDN1 PFDN6 PFDN2 PFDN4 PFDN5 Cerebral organic acidurias, including diseases WP4519 D2HGDH ALDH7A1 L2HGDH ADHFE1 MDH2 GCDH IDH2 Chemokine signaling pathway WP3929 CCL4 CCL5 CCL7 CCL11 GNGT2 GNGT1 GNG11 GNG10 PREX1 ADCY5 GNG7 ADCY6 GNG5 ADCY7 GNG4 ADCY8 FGR ADCY9 GNG3 GNB3 GNB2 CDC42 CCL3 GNG13 XCR1 SHC4 FOXO3 CCR10 CCL17 SHC2 GNG8 CCL20 ROCK2 CCL19 CCL21 CCR2 LYN WAS CCL22 CXCR4 CCR1 CXCR3 GNG12 PXN CXCR5 CCL15 ARRB1 ARRB2 CXCR6 CXCL11 XCL1 CXCL5 STAT2 CX3CL1 STAT1 SOS1 STAT3 HRAS ROCK1 CCL25 CCR8 CCR7 CCR6 CCR4 CCR3 CCL24 RASGRP2 PIK3CG PIK3R1 PIK3R2 PLCB2 PLCB3 PLCB4 RELA CXCL12 PAK1 IKBKB PTK2B PIK3CA PIK3CB TIAM1 PIK3CD CX3CR1 NCF1 CCR9 PARD3 STAT5B AKT3 PRKACB SOS2 PRKACG MAP2K1 ITK PRKCD CXCL16 CXCL14 NRAS GRK6 JAK2 BRAF GRK2 TIAM2 JAK3 VAV3 PRKCB PRKX CCL27 GRK5 GRK4 PF4 PPBP MAPK1 MAPK3 VAV2 HCK PIK3R5 PRKCZ RAP1A CHUK RAP1B AKT1 WASL SHC3 AKT2 PTK2 CCL26 KRAS VAV1 ADCY4 BCAR1 NFKB1 RAC2 NFKBIA ELMO1 NFKBIB GNAI2 GNAI1 GNG2 CXCL3 CXCR2 GRB2 CRKL GNB4 CRK DOCK2 CCL28 PIK3R3 RAC1 CXCL9 SHC1 RAF1 CCL1 GNB1 PLCB1 GSK3B CSK GNAI3 ADCY1 ADCY2 GNB5 IKBKG ADCY3 CXCL13 CXCL10 Cholesterol Biosynthesis Pathway WP197 NSDHL MVD LSS HMGCR FDPS IDI1 HMGCS1 CYP51A1 FDFT1 MVK SQLE DHCR7 MSMO1 PMVK SC5D Cholesterol Biosynthesis with Skeletal Dysplasias WP4804 NSDHL CYP51A1 EBP DHCR24 DHCR7 LBR SC5D Cholesterol metabolism (includes both Bloch and Kandutsch-Russell pathways) WP4718 CH25H SOAT2 MVD FASN CYP46A1 FDPS HMGCS2 CYP51A1 HMGCS1 FDFT1 SREBF2 DHCR24 SOAT1 DHCR7 ELOVL2 LBR MSMO1 SC5D PMVK ABCG1 ACSL1 NSDHL NR1H2 GGPS1 NR1H3 FADS2 SREBF1 LSS ELOVL4 FADS1 ABCA1 HMGCR CYP27A1 ACSL4 ACSL3 ACOT2 MYLIP IDI1 ELOVL3 EBP HSD17B7 MVK SQLE TM7SF2 ELOVL5 SCD Chromosomal and microsatellite instability in colorectal cancer WP4216 TGFB3 TGFBR1 TGFBR2 NTN1 FOS CSNK1A1L TGFB1 TGFB2 MLH1 BCL2L11 CCND1 BCL2 TCF7L1 BRAF MYC CTNNB1 CSNK1A1 APC2 RALA CASP3 RALB MAPK1 MAPK3 TBK1 EXOC2 CDKN1A LEF1 APC ARAF CASP9 AKT1 PTGS2 AKT2 CYCS RALGDS KRAS MSH6 JUN GADD45B RAC2 RAC3 PMAIP1 AXIN1 AXIN2 BAD BIRC5 GADD45G DCC BAK1 MAPK8 RAC1 POLK SMAD2 SMAD3 TP53 SMAD4 RAF1 BAX GSK3B RHOA DDB2 BBC3 AKT3 MAPK9 TCF7 MSH2 MAPK10 MSH3 REL MAP2K1 TCF7L2 APPL1 GADD45A Ciliary landscape WP4352 MCM3 MCM4 MCM5 CNOT10 MCM6 DYNLL1 MCM7 WNK1 UBE2D2 IFT140 COPS3 MCM2 COPS7B GDI1 CEP170 ARL8B DGKE YPEL5 YAP1 EXOSC9 CLUAP1 BBS7 PSMC6 IQGAP2 IFT52 FUZ COX6C IFT81 CALM1 UBE2H CD2BP2 CALM2 PGRMC2 PSMC4 POM121 TBC1D4 WEE1 PAFAH1B1 EXOC7 TFAP2E TTC30B PSMD12 PSMD13 CNOT6L ANKS3 NEFM CAMK2A PSMD7 VPS4A HSPB11 PSMD8 NEFL USH1C IQCB1 NINL RHBDD2 WDR60 CTBP2 ZMYND19 RAB14 EXOC5 NME8 MYL6 EXOC8 SMC4 IFT27 RAB2A ARHGDIA UQCC1 CTNNB1 ZYG11B TNKS1BP1 TTC8 MAEA CDH23 IFT88 EXOSC7 CNOT1 COPS5 CREBBP RAB21 SPATA7 EIF5B RAB3IL1 COPS6 MAPRE2 TFAP2C TFAP2B NFKB1 MCM9 RMND5B IFT80 EIPR1 TFAP2A DCAF11 MCM10 CDR2 CEP97 ANKS6 COPS2 IFT46 RAC1 COPS7A VAPB EXOC6B CCDC40 INTU NUDC MYL6B IQGAP3 MSH2 RANBP9 TMED1 SNAP29 EFTUD2 IFT22 DYNLT3 DYNLT1 RMND5A TTC30A WHRN BBS9 GID4 EXOSC4 CBS GID8 DOCK5 AAR2 RALB DVL3 SNRPB2 AFG3L2 STOM WDR26 TFAP2D ARFGAP3 NDUFA5 COPS4 GLA RAB8A IFT172 CNOT9 DNPEP EHBP1 H3F3A TIPRL BBIP1 DYNLRB2 DCAF7 DYNLRB1 EXOC4 GLB1 DYNC1LI1 NUP133 EXOC6 IQGAP1 LCN2 AIMP1 ARMC8 LCA5 ACSL3 COPS8 LRPPRC XPNPEP3 TRAF3IP1 EFHC2 APMAP MFAP1 EXOC3 LOC101060399 BBS5 WDR34 RNGTT DYNC1I2 ERF IFT57 EXOSC2 DYNC1H1 NUP88 DDX5 IFT122 ECHS1 EXOC1 NEK7 IFT43 CTSA MCM8 EXOC2 APC NEK8 LSM4 HDAC2 HDAC1 HTRA2 RABEP2 EHD3 DYNLL2 RBM14 TCTEX1D2 CEP290 NDUFA9 AGPAT2 VIM IFT20 RPGR MKLN1 BBS1 LZTFL1 BBS2 BBS4 RANBP10 TTC26 SSNA1 MKS1 IFT74 RB1 Ciliopathies WP4803 TULP1 ALMS1 IFT140 PDE6D RPGRIP1L TBC1D32 CENPF ARL2BP BBS9 ADCY6 ZMYND10 FLCN DDX59 CFAP410 CCDC103 DYNC2H1 TMEM138 RSPH4A CCDC151 DNAAF5 KIF7 PKD1 PKD2 AK7 NPHP4 DNAI2 DNAI1 CLUAP1 TAPT1 CEP41 DNAAF2 BBS7 IFT52 INVS CCNO RSPH3 IFT81 CEP83 TMEM107 ARL3 KIZ HYDIN PCARE TMEM216 AHI1 MCIDAS IFT172 TTC21B CPLANE1 RAB28 ICK CCNQ NEK1 NEK2 C8orf37 NME7 EFHC1 CFAP53 BBIP1 TTC25 GALNT11 ANKS3 CEP19 ARL6 PKHD1 DNAH11 POMGNT1 NPHP1 RP1L1 IQCB1 TMEM67 EVC2 UNC119 GPR161 POC1B CCDC28B LCA5 ARL13B DNAAF4 RPGRIP1 B9D1 WDR60 XPNPEP3 CFAP298 B9D2 SDCCAG8 TRAF3IP1 DRC1 MAK WDR35 RAB23 GLI3 CRX GLI2 DNAH6 BBS5 TRIM32 WDR34 HYLS1 CCDC114 SPAG1 KIAA0586 IFT27 IFT57 KIAA0556 CC2D2A PLK4 CNGA1 CNGB1 GAS8 IFT122 TTC8 SUFU PIH1D3 TOPORS BBS10 PIK3R4 IFT43 C2CD3 EVC BBS12 ARMC4 TTLL5 INPP5E TCTN1 WDPCP TCTN3 DNAL1 PIBF1 SPATA7 RSPH1 CSPP1 ZNF423 NEK8 NEK9 TMEM17 IFT80 POC1A RSPH9 DNAJB13 CEP164 MKKS SMO ANKS6 CCDC65 DNAAF1 PKD1L1 NME9 GLIS2 FAM161A TMEM237 CEP290 TCTEX1D2 WDR19 DYNC2LI1 CEP120 TUB ATXN10 KIAA0753 SCLT1 LRRC6 RP2 RP1 CEP104 TTBK2 OFD1 TMEM231 BBS1 CCDC40 BBS2 LZTFL1 BBS4 NPHP3 INTU DCDC2 CFAP52 TCTN2 ZIC2 OCRL USP9X DNAAF3 CEP78 MKS1 Circadian rhythm related genes WP3594 KMT2A RPS27A MAGED1 NLGN1 FAS PRMT5 CSNK1E CSNK1D TPH2 KCND2 PPARGC1A UBC NONO PASD1 NOS2 RBM4 AANAT CST3 OPN4 FBXW11 CIART ID4 GFPT1 PROK1 BHLHE40 SIX3 TNFRSF11A GHRH HNF1B MYBBP1A ADORA1 ADORA2A NPAS2 UBE3A OPRL1 KCNMA1 SERPINE1 NRIP1 RELB PTGDS CPT1A USP2 PTEN CHRM1 CLDN4 MAPK9 MAPK10 CUL1 PER1 TPTEP2-CSNK1E CREB1 CHRNB2 CDK4 LGR4 CIPC NPY2R DRD4 METTL3 DRD3 DRD2 DRD1 PAX4 NR1H3 SREBF1 NFIL3 CRH CREM PROX1 SUV39H1 IL6 BTBD9 CRTC1 PPP1CB PPP1CC RAI1 OGT CAVIN3 PSPC1 MTNR1A ATF5 MTNR1B EGR1 MTTP NAGLU CLOCK TOP2A KCNH7 TP53 HOMER1 SKP1 OPN3 AGRP TOP1 NR1D1 PHLPP1 GSK3B EGR3 TIMELESS TPH1 F7 AHCY EP300 HTR7 AHR EZH2 ARNTL2 NCOA2 DYRK1A NAMPT TH TYMS MTA1 ROCK2 PRF1 BHLHE41 ARNT ARNTL DBP UTS2R RORC STAR PRKAA1 PRKAA2 SLC6A4 RORB RORA UTS2 BTRC ARNT2 CCAR2 SFPQ NPS HDAC3 ID2 ADIPOQ KLF10 NR2F6 RBM4B NTRK1 NTRK3 DDC CRY2 CRY1 HEBP1 CRX PRKCG SLC9A3 NMS PROKR2 PPARA NKX2-1 DHX9 SIN3A NGFR MAGEL2 AVP DDX5 PROK2 ID3 LEP PRKDC SIK1 PRKG2 SFTPC PER2 PER3 SIRT1 JUND KLF9 SUV39H2 PPARG JUN GHRL HDAC2 HDAC1 HNRNPD HCRTR2 HCRTR1 GNA11 SETX MAPK8 HS3ST2 HNRNPU PML NOCT NR1D2 SOX14 UBA52 NCOR1 PPP1CA FBXL3 ATOH7 ADA KDM5A ZFHX3 GNAQ ATF4 ADCY1 MC3R THRAP3 CARTPT Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism WP4523 HSD11B2 HSD11B1 STAR H6PD CYP11A1 HSD3B2 HSD3B1 HSD17B3 CYP21A2 CYP19A1 CYP17A1 CYP11B2 CYP11B1 POR CYB5A SRD5A2 Codeine and Morphine Metabolism WP1604 UGT2B4 UGT2B7 ABCB1 CYP2C8 CYP3A4 CYP2D6 UGT1A6 UGT1A9 ABCC2 UGT1A8 UGT1A10 ABCC3 UGT1A3 UGT1A1 SLCO1B1 Common Pathways Underlying Drug Addiction WP2636 PRKCG CREB1 GRIA3 GNAI1 GRIA2 GRIA1 ADCY8 PRKCA ACTG1 PRKCB CAMK4 ACTG2 DRD4 CAMK2A GJB1 GRIN2A DRD2 GRIN1 DRD1 MAPK1 MAPK3 RAF1 PPP1CA GRM1 GNAS RAP1A RAP1B ARAF GRIA4 ADCY1 PRKACA PPP1CB CALM1 PRKACB PPP1CC PPP1R1A PRKACG ACTB GRM5 CALM2 MAP2K1 MAP2K2 Complement Activation WP545 CFP MASP2 C7 CFD C8A C4A C8B C4B C8G C1QA C1QB C9 C1QC C1R C1S C5 C2 MASP1 CFB C3 C6 CD55 Complement and Coagulation Cascades WP558 PLG SERPINA1 CD46 SERPINF2 F7 F5 F3 CR2 F2R CLTC CR1 F2 SERPING1 C1QA C1QB C1QC C1R C1S C2 LMAN1 C3 C3AR1 VWF THBD F13B SERPIND1 F12 CLU MASP2 F10 F9 F8 C4B SERPINA5 PROC C5AR1 PROS1 C6 CPB2 CFD KLKB1 C7 FGB C8G C9 TFPI SERPINE1 CFH SERPINC1 CFI KNG1 BDKRB1 PLAT PLAU PLAUR CFB MASP1 CD55 Complement system WP2806 CFHR2 SFTPA1 CD46 LAMC1 CSNK1A1 FGG LAMA5 LAMB1 THBS1 WAS SELE FKBP2 SFTPA2 F13A1 F12 TXN F11 F10 CD93 VTN ARRB2 ICAM2 ICAM1 IBSP CFHR4 DCN ADM KLKB1 CD19 ELANE SELP CALR SELL SELPLG VSIG4 FCER2 ITGA2 FCN2 ADIPOQ CPN1 CFI CRP FCGR3A PRKACA PLAUR C1QBP FCN1 PLG CR2 CR1 C5AR2 SERPING1 ITGA2B PRKCA CLEC4M C1R C1S CD40 C2 C3 C3AR1 ITGB3 CFP FGA TLR2 MASP2 FPR1 C4A APCS C4BPA PRNP CD59 ITGAX C5 ITGB2 C5AR1 PROS1 C6 MBL2 SPP1 LRP2 GNAI2 C7 ALB CFD C8A APOA1 FGB C9 GNA15 RPS19 CFH PTX3 GNAI3 MASP1 CFB CD55 Composition of Lipid Particles WP3601 LDLR APOC3 APOA1 LPL APOA2 APOE APOB LCAT CETP Computational Model of Aerobic Glycolysis WP4629 PGK1 GPI TPI1 LDHA ALDOA GAPDH PFKM PGAM2 SLC2A1 ENO1 PKM HK1 Constitutive Androstane Receptor Pathway WP2875 DNAJC7 RXRA ABCB1 HSP90AA1 CYP4A11 CYP2C19 ALAS1 CYP3A5 CYP2B6 CYP3A4 UGT1A6 SP1 NCOA1 PPARGC1A UGT1A3 UGT1A1 UGT1A4 SULT2A1 NCOA2 FOXO1 CYP2C9 NR1I3 SMC1A SULT1A1 EHHADH UGT1A9 NCOA6 ABCC2 ABCC3 PTPA GSTA2 CYP2A6 Control of immune tolerance by vasoactive intestinal peptide WP4484 VIP CTLA4 IL12A TGFB1 IL2 FAS IFNG IL5 CD28 IL4 CD80 IL10 CD86 Copper homeostasis WP3286 MT1E MT1F MT1G SLC11A2 MT1H STEAP3 APP MT1B CCND1 ATOX1 STEAP1 SP1 MT1A CASP3 ADAM17 FOXO3 FOXO1 MT4 SCO2 COX17 STEAP4 APC COMMD1 PRNP MAPT AKT1 JUN ADAM9 BACE1 MDM2 XIAP STEAP2 COX11 MT1X ATP7A SOD1 MT2A SOD3 MT3 XAF1 SLC31A2 SLC31A1 MTF2 SCO1 TP53 CCS MTF1 PIK3CA PTEN ATP7B GSK3B ADAM10 Cori Cycle WP1946 TPI1 PGK1 PGK2 PGAM1 HK1 GPI GPT LDHA GAPDH ALDOA SLC2A1 INS PFKP SLC2A2 TALDO1 SLC2A4 G6PD Corticotropin-releasing hormone signaling pathway WP2355 PRKCD PRKCI FOS CYP11A1 CREB1 GRK6 HSP90AA1 NR4A1 TGFB1 HSD3B2 HSD3B1 IL2 BRAF BCL2 GRK3 CTNNB1 NR4A2 GNB3 GNB2 SP1 PLCG1 PRKCA PLCG2 PRKCB CASP3 SULT2A1 NCOA2 RAPGEF3 NOS3 IVL TLR4 ERN1 MAPK1 MAPK3 FOSL1 CRHR2 CRHR1 CRHBP CRH JUNB JUND KRT1 JUP CYP21A2 RAP1B FOSL2 CASP9 FOSB CYP11B1 PRKCQ AKT1 MAP3K5 ARRB1 PTK2 ARRB2 IL18 NFKB1 STAR NFKBIA PRKAA2 POMC GNAI2 GNAI1 TFAP2A GNA11 MAPK14 CXCL8 ELK1 MAPK8 TRIM28 CAMK2A LINC02210-CRHR1 ACACA TCF4 CASP12 RELA RAF1 GNB1 GNAZ TBX19 PARP1 GNAS GSK3B RHOA GNAQ GNAO1 GJA1 CACNA1H KRT14 GNB5 MAPK9 MAP2K1 ECE1 COVID-19 adverse outcome pathway WP4891 TNF TMPRSS2 IL7 CSF3 AGT ACE2 IL2RA IL2 IL6 CXCL8 IL10 IL1B CCL3 CCL2 CXCL10 COVID-19, thrombosis and anticoagulation WP4927 PLG F2 FGB FGG FGA F13B F13A1 Cysteine and methionine catabolism WP4504 MAT1A ETHE1 AHCY SQOR CTH CSAD CDO1 CBS SUOX BHMT MPST GCLC GSS GOT1 MTR Cytokines and Inflammatory Response WP530 TNF CSF3 HLA-DRB1 IL3 HLA-DRA TGFB1 CSF2 CSF1 IL2 CXCL2 IFNG IFNB1 IL1B PDGFA IL1A IL13 IL7 IL12B IL6 IL15 IL5 IL11 IL4 IL10 CD4 CXCL1 Cytoplasmic Ribosomal Proteins WP477 RPS25 RPS6KA3 RPL24 RPS6KA2 RPL27 RPS27 RPS6KB2 RPL26 RPS26 RPS6KB1 RPL27A RPS28 RPL23 RPS27A RPL30 RPL29 RPL28 RPS29 RPS4X FAU RPL13A RPS5 RPS4Y1 RPS6KA1 RPS6 RPS21 RPS24 RPS23 RPL35 RPL34 RPL3 RPL35A RPL37A RPL4 RPS7 RPL3L RPL37 RPS9 RPL38 RPS8 RPL5 RPL36 RPL31 RPL32 RPS6KA6 RPSA RPL10A RPLP0 RPL7A RPL9 RPL14 RPS15A RPL8 RPLP1 RPL11 RPL10 RPL13 RPL12 LOC101929876 RPL41 RPL39 RPL36A RPL6 RPS11 RPS10 RPS13 RPL7 RPS12 RPS15 RPS14 RPL18A RPL18 RPL21 RPS3 RPL19 RPS2 RPL22 RPS19 UBA52 RPS3A RPS18 RPL23A RPS20 RPLP2 RPL17 RPL15 MRPL19 RPS17 RPS16 Cytosine methylation WP3585 IDH1 DNMT1 TET1 TET3 TDG MECP2 TET2 MBD3 IDH2 Cytosolic DNA-sensing pathway WP4655 FADD CCL4 CCL5 IFNA5 PYCARD IFNA4 IFNA2 ATG12 POLR1D IFNA1 IL1B CGAS CASP1 MAVS POLR3K ATG5 LOC101060521 IFNA21 IFNA17 POLR3C IFNA16 IL6 IFNA14 TBK1 IFNA13 CHUK IFNA10 IFNA8 CASP8 IFNA7 POLR3H IFNA6 CYLD CASP10 RIPK1 IL33 TREX1 RIPK3 POLR3G IL18 POLR3F IKBKE NFKB1 POLR2K POLR2L NFKBIA AIM2 NFKBIB IRF3 DDX58 CCL4L2 CCL4L1 NLRX1 IFNB1 POLR2E POLR3GL ZBP1 POLR2F POLR3B ISG15 POLR2H POLR3A RELA POLR1C TMEM173 IKBKB POLR3D ADAR RNF125 IKBKG IRF7 POLR3E CXCL10 TRIM25 TRADD DDX1 as a regulatory component of the Drosha microprocessor WP2942 MRE11 DDX1 NBN DGCR8 DROSHA RAD50 ATM Degradation pathway of sphingolipids, including diseases WP4153 ARSA GLB1 NEU3 GM2A GLA HEXB HEXA NEU1 NEU2 NEU4 Deregulation of Rab and Rab Effector Genes in Bladder Cancer WP2291 MYRIP MADD RPH3AL RAB27A MLPH RPH3A SYTL1 SYTL5 SYTL4 SYTL3 EXPH5 UNC13D TBC1D10A RAB27B SYTL2 GCC2 Development and heterogeneity of the ILC family WP3893 TOX TNF GFI1 AHR RORA GATA3 AREG HNF1A IL25 IFNG IL9 IL23A IL1B TBX21 IL22 TSLP EOMES NFIL3 ID2 IL7 IL13 IL12B IL12A IL6 BCL11B IL15 IL5 IL4 IL33 ZBTB16 IL18 IL17A Development of pulmonary dendritic cells and macrophage subsets WP3892 IRF4 STAT3 ID2 IRF8 TPO CSF2 RUNX2 CSF1 FLT3LG SPI1 IKZF1 BATF3 TCF4 Development of ureteric collection system WP5053 CELSR1 FREM1 SIX1 SALL1 ROBO2 FOXC1 ROBO1 TGFB2 GRIP1 WNT11 GATA3 RARB CCND1 RARG GDNF SMO FRAS1 SIX2 BMP4 GREB1L CTNNB1 ILK HOXD11 FAT4 SHH ANOS1 SPRY1 LHX1 RET RARA SMAD1 SLIT2 PAX2 FGFR2 WT1 GLI1 ETV4 VANGL2 HOXA11 GFRA1 GDF11 ITGA8 FREM2 ITGB1 MYCN GLI3 GLI2 Differentiation of white and brown adipocyte WP2895 PPARGC1B ZIC1 HSPB7 SMAD5 SMAD9 BMP2 BMP4 BMP7 PPARGC1A EBF3 LEP SMAD1 ADIPOQ CEBPG PRDM16 CEBPB CEBPA MPZL2 CIDEA HOXC9 HOXC8 SLC7A10 PPARG PLAC8 ZNF423 Differentiation Pathway WP2848 HGF TGFB3 VEGFA KITLG EPO IL3 FGF8 TGFB1 NOG WNT2B KIT CSF1R FGF4 CSF1 LEFTY1 BMP4 NT5E FGF2 EGF IGF1 CXCR1 FLT3LG FGF1 NTF4 ALK SHH INS TF DKK1 GDF5 WNT3A WNT2 WNT5A PDGFA PDGFB TNFSF11 WNT7B IL6R CNTF WNT1 TPO NODAL IL6 INHBA IL11 FGF10 NOTCH1 FST Disorders of Folate Metabolism and Transport WP4259 SHMT2 TYMS SLC46A1 ATIC FOLR1 DHFR MTHFD1 MTHFR GART ALDH1L1 MTR MTHFS FTCD Disorders of the Krebs cycle WP4236 DLST SUCLG1 SUCLA2 PDHX DHTKD1 SUCLG2 FH Disruption of postsynaptic signaling by CNV WP4875 SYNGAP1 NRXN3 TJP1 NLGN1 RPH3A NLGN4X NLGN3 GRIN2D GRIN2C DLG1 GRIN2B CAMK2A GRIN2A CAMK2B GRIN1 CAMK2D STX1A CAMK2G NRXN1 RYR2 MAPK1 MAPK3 YWHAG NRXN2 HOMER1 ARC GRM1 CYFIP1 DLG2 FMR1 NLGN2 DLGAP1 SHANK1 DNA damage response (only ATM dependent) WP710 TGFB1 TP73 ATM DVL1 CCND1 BCL2L11 BCL2 MYC FASLG CDC42 BIK FOXO3 RBL2 DVL3 DVL2 MAP3K7 WNT4 MAP3K1 INSR MAP3K4 FRAT1 MLKL PDK1 ABL1 PIK3C2A PIK3C2B PIK3C2G PIK3C3 AXIN1 SOS1 HRAS MDM2 WNT16 CCND2 CCND3 SOD2 PIK3CG WNT3 WNT2 PIK3R1 WNT6 PIK3R2 WNT5A SMAD3 WNT7B WNT7A SMAD4 ERBB2 PIK3CA PIK3CB WNT1 PIK3CD PTEN RHOA LDLR BBC3 HMGB1 AKT3 SOS2 MAPK9 MAPK10 TCF7 PLAU IRS1 TCF7L2 NRAS WNT10B WNT2B WNT11 TCF7L1 WNT10A CTNNB1 MAPK1 PIK3R4 FOSL1 PIK3R5 CDKN2A CDKN1B CDKN1A APC LEF1 AKT1 AKT2 BCL6 PCK2 CAT KRAS JUN NFKB1 RAC2 NFKB2 RAC3 PMAIP1 BAD GRB2 BAK1 MAPK8 PIK3R3 RAC1 WNT3A SCP2 SHC1 TP53 BAX GSK3B WNT5B CCNG2 PPP2R5C PPP2R5E G6PC DNA damage response WP707 RFC1 CREB1 CDK6 CDK5 ATM CDK4 CCND1 BRCA1 CDK2 MYC FAS CCNB3 CDC25A ATRIP CDC25C PIDD1 SESN1 APAF1 BID RAD1 CASP3 PRKDC HUS1B TLK1 CDKN1B CDKN1A RRM2B CASP8 CASP9 CYCS RPA2 E2F1 GADD45B TNFRSF10B ABL1 RAD9A PMAIP1 RAD17 FANCD2 MDM2 CCNB1 GADD45G CCND2 CCND3 CHEK1 H2AFX CCNE1 RAD50 CHEK2 PML MRE11 CCNB2 SMC1A CCNE2 TP53AIP1 RAD52 TP53 NBN BAX SFN DDB2 CDK1 BBC3 ATR TLK2 RAD51 RB1 GADD45A DNA IR-damage and cellular response via ATR WP4016 WRN UBE2D3 XRCC5 HUS1 PPM1D MCM2 MLH1 ATM BRCA1 FOXM1 CDK2 BRCA2 ATRIP CDC25C SP1 UIMC1 BRIP1 HERC2 RAD1 RBBP8 UPF1 DCLRE1A PRKDC EXO1 PCNA TOPBP1 POLN CLK2 FEN1 FANCI TDP1 SMARCAL1 POLB RPA1 MCPH1 PLK1 BCL6 PALB2 RPA2 E2F1 EEF1E1 RECQL5 RAD9A RAD17 FANCD2 FANCA CLSPN CEP164 MDM2 CHEK1 H2AFX SMARCC2 RAD50 CHEK2 TRIM28 SEM1 ABRAXAS1 PML MRE11 USP1 TOP3A SMC1A TP53BP1 MDC1 TP53 NBN RAD52 BRCC3 BARD1 PARP1 CDK1 ATR RFWD3 CDC45 IKBKG RAD51 MSH2 RECQL XPA RMI1 DNA IR-double strand breaks and cellular response via ATM WP3959 RNF8 RASSF1 CDK5 TP73 ATM BRCA1 BRCA2 CDC25C STK3 APAF1 BID UPF1 CASP3 YAP1 PRKDC LATS1 EXO1 PCNA TERF2 HSF1 CDKN2A BLM CASP9 ATF2 MCPH1 E2F1 TRAF6 ABL1 SMC3 RAD9A RAD17 FANCD2 MDM2 RIF1 NABP2 BAK1 CHEK1 H2AFX RAD50 CHEK2 TRIM28 MRE11 SMC1A TP53BP1 MDC1 DCLRE1C TP53 NBN RAD52 BAX PARP1 KAT5 ATR RAD51 ACTL6A DNA Mismatch Repair WP531 PMS2 EXO1 PCNA RFC1 RFC2 RFC3 MLH1 POLE4 POLD3 RFC4 RPA1 POLD1 RFC5 POLD2 RPA3 POLE3 POLE MSH2 RPA2 POLE2 POLD4 LIG1 MSH6 DNA Repair Pathways Full Network WP4946 MBD4 MNAT1 ATM MLH1 POLE4 XRCC6 BRIP1 FAN1 RBX1 OGG1 GTF2H5 PMS2 FAAP100 CETN2 FANCI WDR48 RPA1 POLB POLD1 TDG RPA3 POLD2 RPA2 POLE POLE2 POLH MSH6 MPG MUTYH PNKP FANCD2 FANCC FANCA GTF2H2 GTF2H1 POLL CHEK1 H2AFX NEIL2 POLI RAD50 POLK POLD4 GTF2H4 GTF2H3 MRE11 ERCC1 FANCF FANCB PARP1 DDB2 DDB1 ATR HMGB1 FANCE XPA XPC NTHL1 CUL4A WRN CENPS REV3L RFC1 XRCC5 RFC2 MGMT RFC3 CDK7 ERCC6 FANCL CUL4B ERCC5 RAD54B ERCC4 ERCC3 BRCA1 BRCA2 NEIL3 ERCC2 FANCG XRCC1 XRCC4 PRKDC UNG FAAP24 EXO1 PCNA TERF2 GTF2H2C RAP1A NHEJ1 FEN1 CENPX RFC4 RFC5 APEX1 REV1 PALB2 LIG3 LIG4 ERCC8 POLD3 APEX2 SMUG1 LIG1 PARP2 USP1 DCLRE1C NBN RAD52 POLM FANCM RAD23A POLE3 RAD23B MSH2 CCNH RAD51 MSH3 RAD51C DNA Replication WP466 MCM3 MCM4 MCM5 POLA2 MCM6 ORC4 ORC5 MCM7 RFC1 RFC2 RFC3 POLA1 MCM2 MCM10 CDC6 CDK2 POLD3 UBC PRIM1 PRIM2 POLD4 PCNA UBA52 ORC3 RPA4 GMNN ORC6 CDT1 DBF4 RFC4 RPA1 CDC45 RFC5 POLD1 POLD2 RPA3 CDC7 RPA2 POLE POLE2 ORC1 ORC2 Dopamine metabolism WP2436 TH TYR DDC COMT PRKACA PRKACB SOD1 PRKACG NQO1 MAOA PPP2CA MAOB PPP2CB Dopaminergic Neurogenesis WP2855 SLC18A2 LMX1B SLC6A3 STAT3 FGF8 TGFB1 NR4A2 ALDH1A1 SHH NKX2-2 LMX1A RET NKX6-1 FOXA2 TH NEUROD1 OTX2 MSX1 NEUROG2 EN2 WNT1 GLI1 EN1 CDKN1C DDC ASCL1 SOX2 GLI2 PITX3 GBX2 Drug Induction of Bile Acid Pathway WP2289 NR1H4 NR1I3 ABCB1 VDR SLC10A1 SLC51A CYP7A1 SLC51B BAAT CYP3A4 ABCC2 ABCC3 SULT2A1 NR1I2 ABCB11 ABCC4 SLCO1B1 Dual hijack model of Vif in HIV infection WP3300 RUNX1 APOBEC3G UBB CBFB ELOC RBX1 CUL5 ELOB Ebola Virus Pathway on Host WP4217 HLA-DRB1 EP300 HLA-DRA HLA-DQB2 IGF1R HLA-DQB1 HLA-DQA2 HLA-DQA1 CLTC CLTB HLA-DPB1 CLTA HLA-DPA1 CDC42 VPS33A ADAM17 VPS39 TPCN2 VPS16 HLA-F HLA-E FLNB FLNA HLA-DRB5 CTSB NEDD4 FLNC IKBKE RAB9A STAT1 IRF3 ICAM3 ICAM2 CTSL HAVCR2 HLA-G NPC1 ITGA6 VPS4A IQGAP1 PIK3R1 MFGE8 PIK3R2 RELA ITGA1 PAK1 RELB ITGA2 PIK3CA PIK3CB EPS15 TIAM1 PIK3CD RHOA RHOB RHOC IRF7 VPS41 REL C1QBP TIMD4 PRKRA RFC1 SOCS3 KPNA1 FOLR1 ASGR1 GAS6 AXL EIF2AK2 ITGA3 CLEC4M ITGA4 RAB7A ITGA5 NPC2 TLR4 ITGB3 MAPK1 MAPK3 VAV2 TSG101 BST2 TBK1 HAVCR1 IL4 CREBBP CLEC10A ITGAV MERTK AKT1 ACTB ITGB1 CLEC6A CLTCL1 RAB5A CD300A NFKB1 MBL2 NFKB2 TYRO3 DDX58 TFAP2A SCIN VPS11 CAV1 PIK3R3 ACTG1 CAV2 CAV3 RAC1 EGFR CLEC4G HLA-DOB HLA-DOA TOP1 EIF2S1 HLA-DMB HLA-DMA HLA-C HLA-B HLA-A CD209 DAB2IP ACTN4 RASA2 VPS18 GSN ACTN1 Ebstein-Barr virus LMP1 signaling WP262 TRAF6 NFKB1 CCL20 NFKB2 MAPK1 CCL5 NFKBIA RELA TNF MAP3K7 PDLIM7 IKBKB HSP90AA1 TRAF1 MAP3K14 CHUK IFNB1 CXCL8 MAPK8 IKBKG IRAK1 MAP3K3 TRADD Ectoderm Differentiation WP2858 PPFIBP2 PODXL PTPN13 BOC MYORG NLGN1 FHL2 TSKU ANKS1B MYC TBL1X ARHGAP15 ZFHX4 FOXL1 RAB8B ARHGAP10 ZBTB2 CCDC130 SPRY2 SHH CCL2 SNCA MECP2 HDAC6 ABCC4 LDB2 HESX1 TNFRSF11B LY6E PDE7A CTNND2 BCOR EDA2R GRAMD1B WDR44 RRBP1 SERPINB6 PTPRB AHI1 KIFC3 UBTF SKIL SIX6 TRPM2 STX16 RIT1 DMD GAS2L1 HDAC10 TCF3 BMP4 GLB1 FZD5 BMPR1A PRKAG2 ELOVL2 NLK FZD4 MZF1 SDCBP STC1 PI4KA FZD8 POU2F2 SMAD4 ELOVL4 PIM1 CLVS1 WNT1 RGMA SGSM3 CDH8 CDH6 CTBP1 HMGB2 BAZ1A SOCS2 PAN2 CAP2 SOX2 BCAS3 ST8SIA4 GLI3 NF2 NFATC1 TOX3 RHPN1 NUMA1 NARS2 ARHGDIG ZBTB7B TCF7L1 EDA CTNNB1 CTNNA2 MAFB ROR2 GATA6 TSC22D1 SORCS1 FOXA2 PAX3 HIST1H2BH PHF8 SMURF1 AES JUP TTC14 JAKMIP1 PPARD KCNK10 ARHGEF9 TFAP2C PLXNA2 OGT VAX2 NR2F2 GREB1 PAX6 TFAP2A ARX CELSR2 ZNF219 PGM1 KRT6A LHX1 C1GALT1 PLCXD3 CLDN11 CDON FGFR2 ASTN1 SCHIP1 TRIM33 FYN CCDC88C ZBTB16 MKS1 EDA signaling in hair follicle development WP3930 DKK1 WNT3 EDARADD SOSTDC1 RELB LTB GLI1 DKK4 EDA EDAR SHH BMP1 PTCH1 Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome WP4320 HIST1H3I HIST1H3G HIST1H3C HIST1H3E HIST1H3B HIST1H3J HIST1H3H HIST2H3A HDAC2 H3F3B HDAC1 H3F3A HIST1H3A KDM1A HIST1H3D CBX5 HIST2H3D MTA3 INPP5K HIST1H3F RBBP7 MTA2 CBX1 MTA1 TP53 SREBF1 HIST2H3C CHD3 SUV39H1 RBBP4 LEF1 MBD2 CBX3 E2F1 MBD3 CHD4 RB1 Effects of nitric oxide WP1995 MB HBA1 XDH AOX1 NOS1 COX1 NOS2 NOS3 EGF/EGFR signaling pathway WP437 RPS6KA3 RPS6KA2 NCK1 RPS6KB1 USP8 PTPN11 PTPN12 MAP4K1 RALBP1 RPS6KA1 REPS2 CDC42 SPRY2 RALA STAM2 RALB MEF2A PXDN INPP5D NOS3 INPPL1 EIF4EBP1 FOXO1 MEF2C MYBL2 MEF2D GAB1 PEBP1 STAM TWIST1 ITCH CFL1 NEDD8 STMN1 SH3KBP1 MAP3K1 MAP3K3 MAP3K4 NEDD4 E2F1 ABL1 PIK3C2B STAT1 SOS1 STAT3 RICTOR HRAS ROCK1 EPN1 PTPN5 CAMK2A DNM1 IQGAP1 PIK3R1 NCK2 PIK3R2 NCOA3 PAK1 ARHGEF1 ERBB2 PTK2B RPS6KA5 ARF6 PDPK1 EPS15 PTEN MAP2K5 EPS8 GJA1 STAT5B STAT5A SOS2 MAPK9 IQSEC1 STXBP1 COX2 MAP2K1 MAP2K2 ABI1 PIAS3 HGS PRKCD AURKA ATXN2 PRKCI CREB1 FOS EPS15L1 JAK1 BRAF JAK2 STAMBP SP1 VAV3 PLCG1 PRKCA PLD1 PRKCB PLD2 MAPK1 PCNA VAV2 MAPK4 USP6NL MAPK7 AP2A1 AP2B1 PRKCZ JUND RAP1A MAP3K2 MTOR FOSB AKT1 ERRFI1 TNK2 RALGDS RAB5A SRC PTK2 KRAS JUN VAV1 SH2D2A BCAR1 DOK2 ASAP1 SH3GL2 CBLC GRB10 ELK4 EGF GRB2 MAPK14 CRKL CRK ELK1 MAPK8 PTK6 CAV1 PLSCR1 FOXO4 CAV2 SYNJ1 RAC1 EGFR SHC1 RIN1 RAF1 AP2S1 AP2M1 CSK PLCE1 ATF1 NDUFA13 SH3GL3 CBL CBLB LIMK2 RASA1 GAB2 PTPRR EGFR Tyrosine Kinase Inhibitor Resistance WP4806 HGF NRG2 RPS6KB2 PRKCG RPS6KB1 NRAS IGF1R NRG1 RPS6 CCND1 JAK1 BCL2L11 JAK2 BRAF BCL2 MYC BCL2L1 IGF1 GAS6 AXL PLCG1 NF1 PRKCA PLCG2 PRKCB SHC4 FOXO3 EIF4EBP1 EIF4E GAB1 RRAS2 SHC2 PDGFA MAPK1 PDGFB MAPK3 PDGFRA IL6R EIF4E2 PDGFD IL6 ARAF MTOR AKT1 RRAS AKT2 SHC3 SRC KRAS VEGFA MET SOS1 STAT3 HRAS BAD EGF PDGFC FGF2 GRB2 PDGFRB MRAS PIK3R3 EGFR PIK3R1 PIK3R2 KDR SHC1 TGFA RAF1 FGFR2 ERBB3 ERBB2 FGFR3 PIK3CA PDPK1 PIK3CB BAX PIK3CD PTEN GSK3B AKT3 SOS2 MAP2K1 MAP2K2 Eicosanoid metabolism via cyclooxygenases (COX) WP4719 PLA2G6 ACOX3 PRXL2B PLA2G4A PTGIS PLA2G5 AKR1B1 PTGIR CYP4A11 ACOX1 ACAA1 CYP4F2 ACOX2 PTGFR CYP4F12 PTGES PTGR1 PTGDS PTGDR2 PTGR2 TBXAS1 PTGDR PLA2G4B EHHADH HPGD PPARD PTGS1 PTGS2 CYP4A22 TBXA2R Eicosanoid metabolism via cytochrome P450 monooxygenases (CYP) pathway WP4720 CYP2C8 CYP4F12 CYP4A11 PPARA CYP2C18 PPARG EPHX2 CYP4A22 CYP4F2 Eicosanoid metabolism via lipooxygenases (LOX) WP4721 ACOX3 TRPV1 LTC4S PPARA LTB4R CYSLTR2 CYP4A11 LTB4R2 GGT5 LTA4H ALOX12 TRPA1 ACOX1 ACAA1 CYP4F2 ACOX2 CYP4F12 PTGR1 ALOX5 PTGR2 DPEP1 CYSLTR1 EHHADH FPR2 ALOX15 HPGD ALOX15B PPARD CYP4A22 Eicosanoid Synthesis WP167 PLA2G6 PLA2G2A LTC4S PLA2G4A PTGIS PLA2G5 PNPLA3 GGTLC1 LOC102724197 LTA4H ALOX12 PTGES2 GGT2 GGTLC2 PTGES PTGDS ALOX5 ALOX5AP DPEP1 TBXAS1 GGT1 PLA2G4B ALOX15 ALOX15B PNPLA8 PTGS1 PTGS2 Electron Transport Chain (OXPHOS system in mitochondria) WP111 NDUFA1 NDUFA2 NDUFA3 COX6B1 COX6A1 NDUFS8 NDUFV2 UQCRQ ATP5F1D ATP5F1E NDUFA12 NDUFS2 ATP5PB ATP5MC1 ATP5MC2 NDUFS3 NDUFV1 ATP5MC3 NDUFS4 NDUFS5 NDUFS6 COX6A2 COX8A COX7C COX7B COX7A2 COX7A1 ATP5ME COX6C ATP5PF UQCR10 NDUFA4 NDUFA5 NDUFV3 ATP5IF1 SLC25A27 DMAC2L ATP6 ATP8 ATP5F1A COX15 COX11 ATP5PO NDUFS7 ATP5PD ATP5MG COX5A UCP3 UCP2 SLC25A14 SDHA UCP1 CYTB COX1 COX2 COX3 SDHC SDHB SDHD UQCR11 ATP5MF ND5 ND6 COX17 SURF1 ND1 ND2 ND3 ND4 ND4L UQCRC2 UQCRC1 UQCRFS1 COX7A2L UQCRH SLC25A4 SLC25A5 SLC25A6 UQCRB NDUFA10 NDUFAB1 NDUFB1 NDUFB2 NDUFB3 NDUFA6 NDUFA7 NDUFA8 NDUFA9 SCO1 COX4I1 NDUFB10 NDUFC1 NDUFC2 NDUFS1 NDUFB4 ATP5F1B NDUFB5 NDUFB6 NDUFB7 COX5B ATP5F1C NDUFB8 NDUFB9 Endochondral Ossification with Skeletal Dysplasias WP4808 CAB39 PTH MGP TGFB1 IGF2 TGFB2 IGF1R SERPINH1 IGF1 HMGCS1 DDR2 MEF2C CHST11 ADAMTS1 IFT88 CST5 CDKN1C COL10A1 ALPL CALM1 AKT1 ADAMTS4 PTHLH PTH1R FGF18 CALM2 SLC38A2 THRA SPP1 VEGFA ENPP1 STAT1 GHR COL2A1 ACAN GH1 FGF2 BMP6 BMP7 FRZB NKX3-2 BMPR1A HDAC4 SCIN KIF3A CTSV SOX5 TIMP3 ADAMTS5 SOX9 MMP13 FGFR3 FGFR1 IHH SOX6 RUNX2 RUNX3 PRKACA STAT5B PLAT PLAU GLI3 MMP9 PTCH1 Endochondral Ossification WP474 CAB39 PTH MGP TGFB1 IGF2 TGFB2 IGF1R SERPINH1 IGF1 HMGCS1 DDR2 MEF2C CHST11 ADAMTS1 IFT88 CST5 CDKN1C COL10A1 ALPL CALM1 AKT1 ADAMTS4 PTHLH PTH1R FGF18 CALM2 SLC38A2 THRA SPP1 VEGFA ENPP1 STAT1 GHR COL2A1 ACAN GH1 FGF2 BMP6 BMP7 FRZB NKX3-2 BMPR1A HDAC4 SCIN KIF3A CTSV SOX5 TIMP3 ADAMTS5 SOX9 MMP13 FGFR3 FGFR1 IHH SOX6 RUNX2 RUNX3 PRKACA STAT5B PLAT PLAU GLI3 MMP9 PTCH1 Endoderm differentiation WP2853 SIAH2 TRIM71 RTF1 HHEX TGFB1 APP LAMC1 ZIC5 AHDC1 ZFHX4 UBR5 TCEAL2 EZH2 WWC1 SESN1 RAB38 SLC2A12 SOX7 FOXH1 FOXO1 CEP250 RGS10 SOX17 ATP8B2 DDAH1 HPRT1 WDFY2 CER1 LEO1 NOTCH1 NANOG TAF4B TAF5 TRIM5 EMSY TOX STAT1 CTR9 PIAS1 NOG HNF1B NCAPG2 NABP2 ELAVL1 FOXN3 BMP7 SOX21 BMPR1A TBX21 WDHD1 AEBP2 NLK ACACA TCF4 WNT3 EOMES SMAD2 SMAD3 SMAD4 SFRP1 WNT8A RFX7 BPTF LRPPRC CTBP2 PARP8 TCF7 MIXL1 SOX2 C1QBP GLI2 PHF6 MAP2K3 POU5F1 ZNF281 SP4 CDYL NKX2-1 TOX3 CUL4B PLCH1 MAD2L2 TCF7L1 CDC73 EPB41L5 CTNNB1 GRHL2 VAV3 NR3C1 MBTD1 GATA6 GATA4 ASCC3 FOXA2 TRERF1 PAX3 BCORL1 ONECUT1 DNMT3B NAA15 LEF1 APC FOXA1 CRTC1 TET1 PTHLH JARID2 PBX1 ELP4 EXT1 BTAF1 KDM4A PAX9 RARG DIP2A SFMBT1 ZNF462 ELK4 CEBPZ LHX1 DKK1 MTF2 GDF3 OTX2 PABPC1 HOXA1 PBX3 PRDM14 TNRC6C ZBTB17 SCHIP1 DUSP2 NODAL DAB2 HOXC11 CAND1 ZIC3 NME1 PAF1 DUSP5 DUSP4 Endometrial cancer WP4155 NRAS FOS CCND1 BRAF TCF7L1 MYC CTNNB1 CTNNA2 APC2 CDH1 FOXO3 MAPK1 MAPK3 CTNNA3 CDKN1A APC LEF1 ARAF CASP9 AKT1 AKT2 KRAS GADD45B SOS1 AXIN1 AXIN2 HRAS BAD GADD45G EGF GRB2 ILK FGF2 FGF1 BAK1 ELK1 PIK3R3 POLK EGFR PIK3R1 PIK3R2 TP53 RAF1 CTNNA1 FGFR2 ERBB2 PIK3CA FGFR3 PIK3CB PDPK1 FGFR1 BAX PIK3CD PTEN GSK3B DDB2 AKT3 SOS2 TCF7 MAP2K1 TCF7L2 MAP2K2 GADD45A Endoplasmic reticulum stress response in coronavirus infection WP4861 PPP1R11 PPP1R14C PPP1R15B PPP1R3G PPP1R13B PPP1R15A MBTPS2 PPP1R16A PPP1R16B BCL2 PPP1R14B EIF2AK1 PPP1R12C PPP1R9B MAPK8 EIF2AK2 PPP1R8 PPP1R10 PPP1R1C PPP1R9A ERN1 XBP1 PPP1R3E PPP1R12B ATF6 MBTPS1 PPP1R7 PPP1CA EIF2AK3 PPP1R14A PPP1R3B EIF2S1 PPP1R3D MAP1LC3A ATF4 PPP1R3F PPP1CB PPP1CC PPP1R14D PPP1R1A PPP1R2 DDIT3 HSPA5 PPP1R3A PPP1R12A PPP1R1B PPP1R3C Endothelin Pathways WP2197 CNN1 GNAI1 CAD ADRB1 PTGIR EDNRB CALCA GNG13 PRKCA NPY1R NOS3 GNA15 MAPK1 EDNRA RAF1 PLCB1 GNAS ATP2A2 ADRA1A NPY EDN1 MYL1 CALM1 GNB5 ADCY10 COX2 RIIAD1 RAMP1 MAP2K1 CALM2 CALCRL ECE1 MYLK Energy Metabolism WP1541 PPARGC1B RXRA PRKAA1 PRKAA2 PPARA PRKAB1 PRKAB2 CREB1 TFB2M GABPA EP300 HDAC1 MEF2B MYBBP1A PPRC1 MAPK14 ESRRA TFAM PPARGC1A PPP3CC NCOA1 PPP3R1 PRKAG2 TFB1M PPP3R2 MEF2A CAMK4 FOXO3 FOXO1 MEF2C MEF2D CAMK2G UCP3 UCP2 PRKAG1 PPP3CA PPP3CB PRMT1 SIRT3 SIRT1 GSK3B PRKAG3 ATF2 PPARD PPARG MED1 NRF1 Envelope proteins and their potential roles in EDMD physiopathology WP4535 MAP3K9 TGFB3 NRAS SOS1 SYNE3 HRAS EMD SYNE1 SYNE2 TGFB1 TGFB2 SYNE4 ADCY5 ADCY6 ADCY7 ADCY8 YY1AP1 GRB2 ADCY9 SRF LBR PLEC KIF5B TAZ TMPO SMAD2 MAPK1 SMAD3 MAPK3 SMAD4 SUN1 CFL1 CTGF TMEM43 RHOA LEMD3 ADCY1 ADCY2 SOS2 ADCY3 ADCY10 MAP2K1 MAP2K2 BANF1 KRAS ADCY4 Epithelial to mesenchymal transition in colorectal cancer WP4239 CLDN12 TGFB3 TGFBR1 TGFBR2 OCLN MPP5 CLDN14 TGFB1 SNAI2 TGFB2 RBPJ FOXM1 FOXC2 EZH2 CDH1 MMP15 CLDN23 TWIST2 PDCD6 MEF2D HIF1A FOXQ1 DLK1 PKD1 CLDN8 CLDN15 TWIST1 CLDN10 CLDN1 WNT4 CLDN19 CLDN6 CLDN2 CLDN17 NOTCH1 VTN NOTCH2 NOTCH3 NOTCH4 TRAF6 SOS1 CDH2 HRAS NR2C2 WNT16 CLDN9 FZD5 FZD3 GDF15 CLDN22 NRP2 PKP1 PKP2 WNT3 FZD1 WNT2 FZD4 PIK3R1 STRAP WNT6 PIK3R2 TUSC3 SMAD2 WNT5A MAPK12 SMAD3 CRB3 WNT7B FZD8 SMAD4 WNT7A FZD9 PAK1 WNT8B FZD6 WNT8A FZD7 ID2 ID1 PIK3CA PIK3CB WNT1 PIK3CD MAP2K6 FN1 CLDN7 CLDN3 CLDN4 AKT3 SOS2 MAPK11 MAP2K4 FZD10 ZEB1 MAPK13 MAP2K1 MAP2K2 MAP2K3 CTDSP1 WNT9B WNT9A CLDN5 TJP1 WNT10B WNT2B WNT11 CTNNB1 WNT10A FMNL2 EED ITGA5 JAG2 CLDN18 MAPK1 MAPK3 LATS2 PROX1 JUP DLL4 SPARC AKT1 CLDN20 AKT2 KRAS DLL1 COL4A4 COL4A3 COL4A2 COL4A1 DSP CLDN24 GRB2 MAPK14 NUBPL MAPK8 PIK3R3 ZEB2 LRP6 WNT3A LRP5 CLDN11 TP53 SHC1 RAF1 JAG1 SUZ12 GSK3B RBBP4 WNT5B FZD2 COL4A6 COL4A5 MMP2 DLL3 CDKL2 CLDN16 EIF5A2 SNAI1 TMPRSS4 MMP9 EPO Receptor Signaling WP581 SOCS1 PDK1 STAT1 SOS1 STAT3 EPO JAK2 GRB2 PTPRU PIK3CG IRS2 MAPK1 MAPK3 SHC1 RAF1 CISH EPOR STAT5B AKT1 STAT5A PTPRC RASA1 IRS1 SRC MAP2K1 MAP2K2 ErbB signaling pathway WP673 NRG2 PAK3 NCK1 RPS6KB2 PRKCG RPS6KB1 NRAS PAK5 NRG1 PAK2 BCL2L11 CCND1 BRAF MYC EREG PLCG1 PLCG2 PRKCA PRKCB PAK4 SHC4 EIF4EBP1 FOXO1 GAB1 SHC2 MAPK1 MAPK3 BTC CDKN1B CDKN1A ARAF MTOR AKT1 AKT2 SHC3 SRC PTK2 KRAS JUN ABL1 ABL2 SOS1 HRAS MDM2 BAD AREG GRB2 EGF CRKL NRG3 CRK ELK1 MAPK8 PIK3R3 HBEGF CAMK2A CAMK2B EGFR CAMK2D CAMK2G PIK3R1 NCK2 PIK3R2 TP53 SHC1 TGFA PAK1 RAF1 ERBB4 ERBB3 ERBB2 PIK3CA PDPK1 PIK3CB PIK3CD GSK3B MAP2K7 AKT3 STAT5B STAT5A CBL SOS2 NRG4 CBLB MAP2K4 MAPK9 MAPK10 BUB1B-PAK6 MAP2K1 PAK6 MAP2K2 ERK Pathway in Huntington's Disease WP3853 MAPK1 RAF1 CREB1 HRAS RPS6KA5 HTT GRM1 NTRK2 MAP2K7 CASP7 EGF ELK1 CASP3 BDNF EGFR ESC Pluripotency Pathways WP3931 PTPN11 ACTR2 FGF22 DVL1 ACVR1 DVL3 GAB1 DVL2 PDGFA PDGFB PDGFRA WNT4 ARAF FGF18 FGF20 SOS1 AXIN1 STAT3 ERAS HRAS NOG MDM2 HNF1A WNT16 BMP4 BMPR1A FZD5 FZD3 PDGFRB BMPR1B BMPR2 FGF17 FGF16 WNT3 FZD1 FZD4 WNT2 SMAD1 PIK3R2 WNT6 WNT5A FZD8 WNT7B MAPK12 WNT7A FZD9 SMAD4 FZD6 FZD7 WNT1 PIK3CD MAP2K5 PTEN MAP2K6 AKT3 SELENOP MAP2K1 MAP2K2 MAP2K3 WNT9B FOS SMAD5 SMAD6 WNT10B SMAD7 SMAD9 WNT2B WNT11 JAK1 BRAF CTNNB1 WNT10A MAPK1 MAPK4 MAPK6 MAPK7 IL6ST APC MTOR AKT1 AKT2 JUN FGF19 FGF9 FGF8 FGF7 FGF6 FGF5 FGF23 FGF4 FGF3 GRB2 FGF2 EGF FGF1 ELK1 LIF EGFR LIFR FGF21 LRP6 LRP5 WNT3A RAF1 FGFR4 FGFR2 FGFR3 FGFR1 GSK3B WNT5B FZD2 FGF14 FGF13 FGF12 FGF11 FGF10 Estrogen metabolism WP697 UGT2B7 SULT1E1 GSTM1 SULT1A1 CYP1B1 CYP1A2 COMT UGT1A6 CYP3A4 CYP1A1 UGT1A9 STS ARSD ARSE UGT1A3 UGT1A1 NQO1 GSTA1 Estrogen Receptor Pathway WP2881 NR0B2 PDK4 PPARA STAT3 ESR1 GPAM CYP1B1 CYP1A2 CYP1A1 SP1 PCK1 ACOX1 JUN Estrogen signaling pathway WP712 NFKB1 MAPK1 FOS GNB1 CREB1 ESR1 GNGT1 IKBKB PIK3CA GNAS BCL2 BRAF GPER1 CHUK MAPK14 ELK1 SP1 PRKACA AKT1 IKBKG MAPK9 MAP2K1 JUN Ethanol effects on histone modifications WP3996 KAT2B SLC19A1 ALDH1A2 AHCY HDAC2 HDAC1 ELP3 HDAC10 HDAC7 ALDH1A1 ACSS2 ALDH2 HDAC4 HDAC8 DHFR HDAC6 MTHFR MTR HDAC5 HAT1 TYMS MAT1A HDAC9 HDAC3 CYP2E1 EHMT2 ALDH1A3 ADH1A ADH1B ADH1C ATF2 Ethanol metabolism resulting in production of ROS by CYP2E1 WP4269 MAFG NFE2L2 MAPK8 SP1 PRKCQ CYP2E1 MAFK MAFF MAP2K1 MAP2K2 Eukaryotic Transcription Initiation WP405 POLR2K MNAT1 CDK7 POLR1A ERCC3 POLR1D GTF2H2 GTF2H1 TBP GTF2F2 ILK GTF2E2 GTF2E1 ERCC2 POLR2E POLR3B POLR2F POLR2G POLR2H POLR2I POLR2J GTF2H4 GTF2H3 POLR3K TAF9 POLR2A TAF12 POLR2B POLR2C GTF2H2C TAF13 LOC101060521 POLR1E POLR3D POLR3H TAF6 TAF5 CCNH GTF2B GTF2A2 POLR1B POLR3E TAF7 EV release from cardiac cells and their functional effects WP3297 TNF CXCL12 RGS16 ERBB4 KLF2 MYB PRL Exercise-induced Circadian Regulation WP410 PER1 CLDN5 UGP2 HSPA8 VAPA PURA GSTM3 HIST1H2BN PER2 TUBB3 RBPMS TOB1 ETV6 MYF6 KLF9 SF3A3 GSTP1 EIF4G2 GFRA1 G0S2 ARNTL HERPUD1 NCKAP1 PPP1R3C SUMO1 QKI PSMA4 ERC2 NCOA4 PIGF BTG1 AZIN1 ZFR STBD1 PPP2CB UCP3 CLOCK NR1D2 CEBPB TAB2 HLA-DMA DNAJA1 IDI1 SUMO3 DAZAP2 CBX3 CRY2 CRY1 exRNA mechanism of action and biogenesis WP2805 DICER1 XPO5 DROSHA DGCR8 ERI1 AGO2 Extracellular vesicle-mediated signaling in recipient cells WP2870 HGF TGFB3 TGFBR1 TSPAN8 TGFBR2 MET NRAS AXIN1 TGFBR3 HRAS TGFB1 TGFB2 DKK4 CTNNB1 EGFR WNT3A MFGE8 SMAD2 WNT5A SMAD3 PROM1 SMAD4 TGFA RAF1 ERBB2 PIK3R5 APC MTOR AKT1 KRAS Extracellular vesicles in the crosstalk of cardiac cells WP4300 SPP1 STAT3 SORBS2 BIRC5 HSPB1 EGF IGF1 CD81 SOD1 EGFR PDLIM5 GATA4 TLR4 KDR PTEN IL6 ETS2 CD63 MMP9 Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling WP3850 PDK1 NFKB1 EIF2B2 RPS6KB1 FBXO32 PRKAB1 DEPTOR RICTOR IGF1R ILK IGF1 RPTOR PPARGC1A PLD1 ACVR2B NEB JKAMP EIF4E PIK3CG TNFRSF1A SMAD2 SMAD3 MLST8 TNFSF9 MSTN PTEN GSK3B AKT1S1 TRIM63 MAP1LC3A IGFBP5 MTOR AKT1 MAPKAP1 WASL ITGB1 IRS1 Farnesoid X receptor pathway WP2879 NR1H4 UGT2B4 NR0B2 IRS2 RXRA FGF19 ABCB4 SLC10A1 CYP8B1 CYP7A1 BAAT SLC27A5 CYP3A4 SLCO2B1 FKBP5 PPARGC1A SULT2A1 ABCB11 IP6K3 Fas ligand pathway and stress induction of heat shock proteins WP314 FADD TNF MAPKAPK2 PAK2 LMNB2 ARHGDIB DFFB BCL2 SPTAN1 HSPB1 DFFA FAS FASLG MAPK8 APAF1 FAF1 RIPK2 ACTG1 CASP3 DAXX CASP6 PRKDC ACTA1 LMNA LMNB1 PAK1 MAP3K7 IL1A PARP1 CASP7 CASP8 CASP9 CASP10 MAP3K1 MAP2K4 ACTB CYCS MAPKAPK3 NFX1 CFLAR RB1 JUN Fatty acid beta-oxidation WP143 TPI1 LIPF CRAT CHKB ACSL6 ECI1 GPD2 CPT2 PNPLA2 ECHS1 CPT1B ACSS2 DLD ACSL5 ACSL1 ACADL ACADM ACADS ACADVL LIPC ACAT1 LPL LIPE CPT1A HADH HADHB HADHA ACSL4 ACSL3 GK2 DECR1 GK SLC25A20 GCDH Fatty Acid Biosynthesis WP357 ACSL1 ACLY ECH1 HADH PC FASN ACSL4 ACSL3 ACSL6 DECR1 ACAA2 ECHDC3 MECR ECHS1 ECHDC2 ECHDC1 ACSS2 PECR SCD ACACA ACSL5 ACACB Fatty Acid Omega Oxidation WP206 CYP2E1 ADH6 ADH7 CYP4A11 ADH1A CYP1A2 ADH1B CYP3A4 CYP2D6 CYP1A1 ADH1C ADH4 ALDH1A1 ALDH2 CYP2A6 Fatty acid transporters WP5061 ACSL1 FABP7 FABP6 ACSBG1 FABP5 ACSL4 ACSBG2 ACSL6 FABP3 ACSL3 FABP9 DBI SLC27A4 FABP2 FABP1 FABP4 CD36 ACSL5 FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma WP4553 HIST1H3I HIST1H3G HIST1H3C HIST1H3E HIST1H3B HIST1H3J HIST1H3H HIST2H3A H3F3B H3F3A HIST1H3A HIST1H3D HIST2H3D H2AFJ EZH2 H2AFZ H2AFX H2AFY2 EED HIST1H3F H2AFB2 RNF2 MAPK1 MAPK3 H2AFV H2AFY H2AFB1 HIST2H3C SUZ12 PCGF1 BCOR H2AFB3 KDM2B BCL6 DUSP6 Ferroptosis WP4313 MAP1LC3C SLC11A2 SLC39A8 FTH1 SLC40A1 NCOA4 STEAP3 HMOX1 ACSL6 CYBB CP MAP1LC3B TF SAT1 VDAC2 GCLC VDAC3 ACSL5 ATG7 ACSL1 SLC39A14 ATG5 SLC3A2 TFRC TP53 LPCAT3 PCBP1 FTMT PCBP2 ACSL4 SLC7A11 ACSL3 FTL ALOX15 GCLM MAP1LC3A PRNP SAT2 GSS GPX4 FGF23 signaling in hypophosphatemic rickets and related disorders WP4790 ROS1 PHEX NFKB1 KL NFKB2 SPP1 ENPP1 PTH CYP27B1 FGFR2 CYP24A1 FGFR3 GALNT3 SLC34A3 FGF23 CCND1 FAM20C CDKN1A CYP11B2 ALPL SLC34A1 DMP1 FGFR3 signaling in chondrocyte proliferation and terminal differentiation WP4767 THRA STAT1 FGF9 BMP2 BMP4 MAPK14 RBL1 PPP2CA ATG5 MAPK1 MAPK12 MAPK3 SOX9 RAF1 NPR2 FGFR3 IHH CDKN1A CNP MAPK11 PTHLH PTH1R FGF18 MAPK13 SNAI1 MAP2K1 MAP2K2 Fibrin Complement Receptor 3 Signaling Pathway WP4136 CD14 PLG TRAF6 NFKB1 TIRAP SYK TNF IRF3 ITGAM LY96 TICAM1 CXCL3 IFNB1 FGB FGG RASSF5 CCL2 IRAK1 NOS2 IRAK2 TLR4 TLR3 TICAM2 FGA IKBKB IL12B PIK3CA IL6 RHOA CHUK LBP IRAK4 TYROBP AKT1 IKBKG CBLB PLAT ITGB2 SRC MYD88 CXCL10 Fluoroacetic acid toxicity WP4966 ALDH9A1 ALDH3A2 CS ACSS2 ALDH2 ACO2 Fluoropyrimidine Activity WP1601 CES1 SLC29A1 TK1 SMUG1 ERCC2 CES2 DHFR ABCC5 CDA MTHFR ABCC4 XRCC3 RRM2 RRM1 PPAT TYMS UPP1 TP53 TYMP UMPS UCK2 UCK1 FPGS ABCC3 ABCG2 TDG UPP2 DPYS GGH DPYD UPB1 SLC22A7 CYP2A6 Focal Adhesion WP306 HGF CCND1 BCL2 LAMA1 SHC4 VWF PDGFA PDGFB PDGFRA FLNB FLNA PXN CHAD VTN TESK2 FLNC FLT1 PDGFRB ITGA6 PIK3R1 PIK3R2 KDR PAK1 ITGA1 ITGA2 PIK3CA PDPK1 PIK3CB PIK3CD PTEN RHOA FN1 STYK1 PIP5K1C CAPN2 MAPK9 MYL2 MAPK10 MAP2K1 MYL5 MYLK PAK3 ITGA9 ARHGAP35 ARHGAP5 PAK2 CTNNB1 ITGA2B ITGA3 ITGA4 PAK4 ITGA5 ITGA7 ITGB3 ITGB4 PPP1R12B ITGB5 ITGB6 ITGB7 PDGFD MYL12A ITGAV PPP1CB PPP1CC ACTB TNK2 ITGB1 PTK2 SRC PPP1R12A TNR BCAR1 PARVG RAC2 RAC3 TNXB COL4A4 COL4A2 COL4A1 COL2A1 EGF CRKL COL1A2 COL1A1 CRK ELK1 ITGB8 PTK6 MYL10 CAV1 ACTG1 MYL9 CAV2 CAV3 RAC1 SRMS EGFR RAF1 COL6A2 COL5A2 GSK3B LAMA2 COL4A6 LAMA3 ACTN4 DIAPH1 RELN PAK6 ACTN1 IGF1R LAMB2 LAMB3 LAMC1 PARVB IGF1 FGR LAMC2 CDC42 LAMA4 MYLK3 LAMA5 LAMB1 ITGA11 SHC2 THBS1 ROCK2 THBS3 THBS2 TNC TXK BLK VEGFD MYLK2 TNK1 MET SOS1 HRAS THBS4 TNN ROCK1 IBSP CCND2 PDGFC PPP1R12C CCND3 PARVA ERBB2 MYLPF AKT3 COL5A3 PRKCG BRAF VAV3 PRKCA PRKCB MAPK1 MAPK3 VAV2 HCK TLN1 RAP1A RAP1B TLN2 AKT1 MYLK4 SHC3 AKT2 BIRC2 PGF VASP VAV1 JUN VEGFA SPP1 VEGFC VEGFB BIRC3 BAD RAPGEF1 XIAP ILK GRB2 COMP LAMC3 MYL7 DOCK1 MAPK8 VCL PIK3R3 ZYX SHC1 PPP1CA FYN ITGA8 ITGA10 BUB1B-PAK6 RASGRF1 MYL12B Focal Adhesion-PI3K-Akt-mTOR-signaling pathway WP3932 HGF TCL1B GNGT2 GNGT1 OSMR GNG11 GNG10 GNG7 GNG5 GNG4 LAMA1 GNG3 GNB3 GNB2 INS GNG13 PPARGC1A RAB10 NOS1 NOS2 FOXO3 NOS3 ULK1 FOXO1 VWF GNG8 HIF1A IRS2 PDGFA PDGFB PDGFRA CHAD VTN INSR LPAR1 PIK3C2A PIK3C2B GHR MDM2 FLT4 RPTOR FLT1 PDGFRB RHEB ITGA6 ACACA PIK3CG PIK3R1 PIK3R2 KDR ITGA2 PHLPP2 IKBKB PIK3CA PIK3CB PDPK1 PIK3CD CAB39L PTEN CHRM2 CHRM1 FN1 AKT1S1 CREB3L3 RAB14 IRS1 MAP2K1 MAP2K2 ITGA9 ITGAD CDC37 ITGAE TSC1 ITGAL NRAS RAB2A IL3RA CREB1 HSP90AA1 IL2RG IL2RB PRLR IL2RA IL2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA7 PRL TEK ITGB3 ITGB4 ITGB5 ITGB6 CREB3L2 SREBF1 ITGB7 IL6R ANGPT1 ANGPT2 EFNA2 EFNA1 PDGFD PPP2R3C HSP90AB1 CDKN1B CDKN1A IL4R ATF6B IFNA7 CASP9 MTOR ATF2 ITGAV TSC2 ITGAX ITGB1 ITGB2 PTK2 EFNA5 EFNA4 EFNA3 TNR TNXB TCL1A PPP2R2B COL4A4 FGF9 FGF8 COL4A2 FGF7 FGF6 COL4A1 IRS4 COL3A1 COL2A1 PPP2R1B FGF4 FGF3 EGF FGF2 COL1A2 FGF1 IFNB1 COL1A1 IFNAR2 IFNAR1 IL7R ITGB8 PPP2CA PPP2CB EGFR FGF21 PPP2R1A LPAR6 RAF1 FGFR4 FGFR2 FGFR3 COL6A2 FGFR1 COL5A2 PHLPP1 GSK3B FGF14 FGF13 COL5A1 FGF12 COL4A6 LAMA2 FGF11 LAMA3 FGF10 PPP2R2C PPP2R3A PIK3IP1 PPP2R5A EPHA2 PPP2R5B PPP2R5C RELN PPP2R5D PPP2R5E CREB5 RPS6KB2 RPS6KB1 EPAS1 FGF22 LPAR3 IGF1R RPS6 LAMB2 LAMB3 EIF4B LAMC1 F2R EIF4E1B IGF1 LAMC2 PPP2R2D LAMA4 LAMA5 EIF4EBP1 LAMB1 EIF4E ITGA11 THBS1 THBS3 THBS2 STRADA RAB11B TNC TBC1D1 EIF4E2 GNG12 VEGFD SLC2A1 ANGPT4 SLC2A3 SLC2A2 FGF18 SLC2A4 RAB8A FGF20 PRKAA1 PRKAA2 SOS1 MET EPO HRAS THBS4 LPAR5 TNN IBSP HSP90B1 KIT PDGFC ELAVL1 FGF17 FGF16 LPAR4 MLST8 PFKFB4 HIF3A DDIT4 EPOR AKT3 CREB3 PFKFB1 PFKFB2 PFKFB3 COL5A3 CAB39 STK11 KITLG NGFR JAK1 JAK2 JAK3 NGF MAPK1 MAPK3 PIK3R4 CREB3L1 PIK3R5 GYS2 GYS1 COL11A2 COL11A1 FOXA1 CREB3L4 AKT1 AKT2 PGF KRAS PELO SPP1 VEGFA FGF19 VEGFC VEGFB CSF3 BAD CSF1R GNG2 CSF1 GRB2 COMP LAMC3 GNB4 LIPE GNB1 LPAR2 CRTC2 CSHL1 CSH1 ATF4 CSF3R ITGA8 IKBKG ITGA10 OSM Folate Metabolism WP176 SHMT2 PLG TNF F7 FOLR3 AHCY FOLR2 HBB SHMT1 FOLR1 IL2 HBA1 F2 CBS IL1B FGG INS CCL2 MTHFD1 NOS1 MTHFR SERPINA3 MAT1A SAA2 SAA1 IZUMO1R ABCA1 FLAD1 FGA GPX3 GPX2 GPX1 IL6 GPX6 IL4 INSR CAT GPX4 MTHFS NFKB1 SLC19A1 NFKB2 MPO SLC46A1 MTRR ICAM1 SAA4 CSF1 IFNG ALB APOA1 FGB APOB DHFR SOD1 SOD3 MTR SOD2 MTHFD2 SERPINE1 RELA TP53 CTH LDLR CRP RFK PLAT GART SCARB1 Folate-Alcohol and Cancer Pathway Hypotheses WP1589 CBS ALDH1A1 ADH5 CREB1 CYP2E1 MTHFR CEBPB ALDH1L1 MTR Follicle Stimulating Hormone (FSH) signaling pathway WP2035 RPS6KB2 RPS6KB1 CREB1 GRK6 HIST3H3 FSHR CGA RPS6 AREG FSHB MAPK14 SGK1 PRKCA RHEB FOXO1 EIF4EBP1 MAPK1 MAPK3 RAF1 CYP19A1 MTOR PRKACA AKT1 TSC2 BDNF SRC APPL1 FOXA2 pathway WP5066 FOXA2 PPARGC1B IRS2 SREBF1 FASN MLXIPL SLC27A5 ABCC2 FOXA1 APOB ABCC3 INS GSTA2 GSTA1 IRS1 ABCC4 MTTP ACACA FOXO1 GSTM2 SLCO1B1 FOXP3 in COVID-19 WP5063 STAT3 IL6ST IL2RG IL2RB IL6R IL2RA IL6 IL2 CD28 CD80 CD86 IL7R STAT5B STAT5A FOXP3 Fragile X Syndrome WP4549 PICK1 PTPN11 RPS6KB1 ARHGAP32 DEPTOR APP EIF4A1 CLTC CLTB CLTA KCND2 MECP2 EIF4EBP2 GAB1 EIF4E ABAT GABRB2 EPHA4 DLG4 GABRA1 EIF4G1 TBC1D7 ARAF TBC1D7-LOC100130357 CAMK1 ABCD3 PDK1 SYNGAP1 TECR SOS1 TARBP2 AGAP2 GAD1 GRIP1 PTPN5 GABRG2 RPTOR GABRD RHEB EEF1A1 CAMK4 CAMK2A DNM1 CAMK2B SLC6A1 TELO2 HCN1 MLST8 PRKAR1A CPT1A AKAP5 PIK3CB PTEN NTRK2 ITPR1 AKT1S1 FMR1 PRKACA GPHN MAP2K1 MAP2K2 DICER1 MAP1B TSC1 CREB1 CYFIP2 BRAF DLGAP3 PLCG1 NF1 PRKCA MKNK1 GRIN2B GRIN2A AGO2 GRIN1 ALDH5A1 TTI1 MAPK1 SLC16A1 AP2A1 AP2B1 GRM1 CDKN2A CNR1 DNM2 RAP1GAP MTOR AKT1 TSC2 CLTCL1 GRM5 SRC KRAS SH3GL1 GRIA2 GRIA1 HOXB8 GRB2 PPP3CA SHC1 HOMER1 RAF1 PPP1CA AP2S1 AP2M1 PLCB1 ARC CYFIP1 FYN ALDH3A2 GRIP2 SH3GL3 BDNF PPP2R5B DAG1 MMP9 KCNC1 DUSP3 EPS8L1 SHANK1 FTO Obesity Variant Mechanism WP3407 FTO ARID5B IRX3 PPARGC1A PRDM16 IRX5 TBX1 UCP1 G Protein Signaling Pathways WP35 AKAP7 PDE4A PDE4B PDE4C PDE4D KCNJ3 PRKD3 GNGT2 GNGT1 GNG11 GNG10 ADCY5 ADCY6 GNG7 GNG5 ADCY7 ADCY8 GNG4 ADCY9 GNG3 GNB3 GNB2 PPP3CC GNG13 PDE1C GNA14 PDE8A PDE1B GNG8 AKAP12 AKAP6 PDE7A GNG12 RRAS CALM1 AKAP9 CALM2 HRAS AKAP1 PRKAR1A PLCB3 PRKAR1B PRKAR2A ARHGEF1 PDE7B AKAP5 AKAP2 RHOA ITPR1 PRKACA PRKACB PRKACG AKAP13 AKAP10 AKAP11 PRKCD PRKCE PRKCG PRKCH PRKCI NRAS PRKD1 AKAP4 PRKAR2B PRKCA PRKCB SLC9A1 PDE8B PRKCZ PRKCQ KRAS ADCY4 AKAP8 GNAI2 GNAI1 GNA12 GNA11 GNA13 GNA15 PPP3CA PDE1A GNB1 GNAZ GNAS GNAQ GNAO1 GNAL GNAI3 ADCY1 GNB5 ADCY2 ADCY3 AKAP3 G1 to S cell cycle control WP45 MCM3 MCM4 MCM5 POLA2 MCM6 MCM7 MNAT1 CDK7 CREB1 CDK6 MCM2 ATM CDK4 CCND1 CDK2 MYC CDC25A PCNA MYT1 CREB3L1 CDKN2D CDKN2C CDKN2B CDKN2A CDKN1C CDKN1B CDKN1A ATF6B CREB3L4 RPA1 RPA3 POLE RPA2 POLE2 E2F1 ORC4 ORC5 WEE1 TFDP1 MDM2 CCNB1 CCND2 CCND3 E2F3 E2F2 CCNE1 PRIM1 PRIM2 CCNA1 CCNE2 TP53 ORC3 CDK1 CREB3L3 ORC6 CDC45 TFDP2 CCNG2 CCNH CREB3 ORC1 ORC2 RB1 GADD45A G13 Signaling Pathway WP524 PAK3 RPS6KB1 PKN1 ROCK1 ARHGDIB MYBPH ARHGDIG RHPN2 CDC42 PFN1 GNA13 RAC1 IQGAP1 PIK3R2 RTKN ROCK2 WAS ARHGEF1 CFL2 PIK3CA PIK3CB CFL1 PIK3CD CYFIP1 IQGAP2 RHOA SH3RF1 PPP1CB CALM1 MYL1 LIMK1 WASL CIT DIAPH1 TNK2 PIP4K2A MAPK10 MAP3K4 CALM2 GABA metabolism (aka GHB) WP4157 AKR7A2 DPEP1 ABAT PON3 ADHFE1 GABA receptor Signaling WP4159 GABBR2 GABBR1 GAD2 GAD1 GABRP GABRG3 GABRG2 GABRG1 GABRE GABRD SLC32A1 SLC6A1 ABAT GABRB3 AP2S1 GABRB2 GABRB1 AP2A1 AP2M1 AP2A2 AP2B1 GABRA6 GABRA5 GABRA4 ALDH9A1 GABRA3 GABRA2 GABRA1 GABRQ GPHN SLC6A11 Galanin receptor pathway WP4970 PRKCD VEGFA KRT19 POMC FOS CREB1 ADIPOQ UCP1 TFAP2A BCL2L11 CDKN1C IL6 CRP CDKN1B CDKN1A INS PPARGC1A PPARG VAMP2 SLC2A4 YAP1 Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases WP4518 DPEP1 GGT2 GGT1 GGTLC2 LOC102724197 GGCT OPLAH GCLC GSS GGTLC1 Ganglio Sphingolipid Metabolism WP1423 ST3GAL2 ST3GAL1 ST8SIA5 ST8SIA1 B4GALNT1 SLC33A1 A3GALT2 FUT1 ST8SIA3 ST3GAL5 ST6GALNAC6 B3GALT1 B3GALT4 Gastric acid production WP2596 GRP SCT VIP CCK GAST GIF MUC6 Gastric Cancer Network 1 WP2361 AURKA MCM4 CASTOR3 ESM1 KIF20B UBE2C CENPF NUP107 LIN9 H3F3A TPX2 E2F7 INO80D KIF15 ECT2 RNF216 CEP192 GATD3A CCNA1 SMOC2 MYBL2 RUVBL1 TOP2A S100P APC GATD3B NOTCH1 HIST4H4 ACTL6A Gastric Cancer Network 2 WP2363 S100A6 UBE2C AHCTF1 RAD17 RFC3 DSCC1 CHTF18 MTDH LMNB2 UBE2T MYC CTNNB1 ATAD2 COL9A3 CACYBP CEBPZ LBR EGFR SNURF TOP2A TP53 FAM91A1 COL9A1 OTUD5 BRIX1 RNF144B CD48 FANCI RFC4 CHTF8 PLAC8 Gastrin signaling pathway WP4659 RPS6KB1 MAP3K11 PTPN11 PRKD2 RPS6 MEF2B CCND1 MYC BCL2L1 CDC42 LAMTOR3 CDH1 FOXO3 FOXO1 MEF2C EIF4EBP1 MEF2D CLDN1 PXN CCKBR ARRB1 ARRB2 ARHGEF28 SOS1 STAT3 HRAS ROCK1 BMP2 KIT ELAVL1 CHGA TCF4 PIK3R1 PIK3R2 SERPINE1 SERPINB2 RELA PAK1 IKBKB PIK3CA KAT5 RHOA RHOB ANXA2 PRKACA MAPK9 IRS1 MAP2K1 PRKCD PRKCE PRKCH SLC9A3 PRKD1 CREB1 FOS TJP1 JAK2 IL2 CTNNB1 RHOD HDAC7 SP1 PLCG1 PRKCA SLC9A1 CASP3 MAPK1 MAPK3 KLF4 CDKN2A CDKN1B CD44 CHUK CDKN1A MTOR ATF2 YES1 PRKCQ PPARG AKT1 PTGS2 BIRC2 ITGB1 PTK2 SRC KRAS JUN BCAR1 NFKB1 NFKBIA VEGFA HDC BIRC3 BAD BIRC5 GRB2 MAPK14 CRK GAST CXCL8 ELK1 MAPK8 PIK3R3 EGR1 RAC1 EGFR TFF2 SHC1 RAF1 JAG1 GSK3B GNAQ FYN MMP7 GDNF/RET signaling axis WP4830 PAX2 SLIT2 SOX17 SALL1 SOX11 IFT27 FOXC1 ROBO2 AGTR2 GATA3 GDNF EYA1 FOXC2 BMP4 CTNNB1 FAT4 GFRA1 GREM1 SPRY1 LHX1 HSPB11 RET GLI3 Gene regulatory network modelling somitogenesis WP2854 HES1 MESP2 WNT3A RIPPLY2 HES7 NOTCH1 DLL1 FGF8 TBX6 EPHA4 LFNG Genes controlling nephrogenesis WP4823 NCK1 LMX1B SIX1 VEGFA CD2AP FOXD1 FGF8 ROBO2 FOXC1 LAMB2 GDNF KIRREL1 FOXC2 ILK CTNNB1 HOXD11 SHH PDGFRB ITGA3 TCF21 LHX1 NPHS1 RET NCK2 PAX2 SLIT2 PDGFB KDR CXCL12 CXCR4 FGFR2 WNT4 WT1 ETV4 HOXA11 EMX2 EYA1 ITGA8 NOTCH2 ITGB1 CD36 GLI3 NPHS2 Genes related to primary cilium development (based on CRISPR) WP4536 DYNLL1 DYNLT1 TULP3 IFT140 IQCE RPGRIP1L TXNDC15 BBS9 TEDC1 DYNC2H1 CLUAP1 KIFAP3 CPLANE2 BBS7 IFT52 FUZ IFT81 CEP83 TMEM107 ARL3 TMEM216 KATNB1 IFT172 TTC21B CPLANE1 FGFR1OP ICK CEP44 TTC30B CEP19 ARL6 CEP76 HSPB11 TMEM67 EVC2 CDK20 ARL13B KIF3B MIB1 WDR60 B9D1 EFCAB7 TRAF3IP1 FBF1 WDR35 RAB23 WDR34 BBS5 IFT27 IFT57 CEP162 CC2D2A FOPNL FAM92A CEP295 TTC8 IFT122 CEP192 BBS10 IFT88 IFT43 C2CD3 EVC SASS6 BBS12 INPP5E TUBE1 TUBD1 TCTN1 TCTN3 TRAPPC11 WDPCP PIBF1 RABL2A TMEM17 IFT80 MKKS TTC23 CEP97 IFT46 TCTEX1D2 DYNC2LI1 KIF3A WDR19 CEP120 KIAA0753 SCLT1 IFT20 CEP104 CBY1 TTBK2 BBS1 TMEM231 OFD1 BBS2 LZTFL1 TEDC2 BBS4 ARMC9 TCTN2 TTC26 IFT74 MKS1 Genes targeted by miRNAs in adipocytes WP1992 HAND2 TMSB4X ERG PTBP2 KCNJ2 IGF1 GJA1 HCN2 HDAC4 KCNQ1 SRF HCN4 KCNE1 Genotoxicity pathway WP4286 TP53I3 RPS27 PCDH8 DAAM1 PLK3 SMAD5 CENPE PPM1D MEX3B DCP1B E2F8 RBM12B TIGAR CCP110 BTG2 BLOC1S2 PTGER4 EI24 TOPORS TM7SF3 HIST1H2BN DUSP14 HIST1H2BM HIST1H2BC ACTA2 HIST1H2BI SEL1L LCE1E PHLDA3 HIST1H1E CDKN1A RRM2B BRMS1L SERTAD1 TRIAP1 HIST1H2BG TNFRSF17 TRIM22 ITPKC PRKAB1 PRKAB2 HIST1H3D NLRX1 MDM2 B3GNT2 E2F7 HIST1H2BB IKBIP GXYLT1 SEMG2 ARRDC4 AEN ID2 CEBPD RAPGEF2 COIL FBXO22 DDB2 ITPR1 LRRFIP2 CBLB AMER1 GADD45A Glial Cell Differentiation WP2276 MAG MBP PLP1 CNP TPPP GAP43 MSN Glioblastoma signaling pathways WP2261 PRKCD PRKCG PRKCH PRKCI TSC1 NRAS CDK6 EP300 IGF1R ATM CDK4 CCND1 BRCA1 BRAF CDK2 BRCA2 SPRY2 NF1 PLCG1 PRKCA PLCG2 PRKCB FOXO3 FOXO1 GAB1 MAPK1 MAPK3 PDGFRA CDKN2C CDKN2B PRKCZ CDKN2A CDKN1B CDKN1A ARAF PRKCQ AKT1 TSC2 ERRFI1 AKT2 SRC E2F1 KRAS MSH6 MDM4 PIK3C2A PIK3C2B PIK3C2G MET HRAS MDM2 CCND2 GRB2 CCNE1 PDGFRB FOXO4 EGFR PIK3CG PIK3R1 PIK3R2 TP53 RAF1 ERBB3 FGFR2 ERBB2 PIK3CA FGFR1 PDPK1 PIK3CB PIK3CD PTEN MAP2K5 MAP2K6 MAP2K7 AKT3 CBL MAP2K4 IRS1 MAP2K1 MAP2K2 RB1 MAP2K3 Globo Sphingolipid Metabolism WP1424 ST3GAL2 ST3GAL1 ST6GALNAC1 ST8SIA1 ABO FUT9 ST6GALNAC5 GCNT1 GBGT1 GALNT2 ST6GAL1 FUT2 FUT1 B3GALT5 ST6GALNAC3 ST6GAL2 ST6GALNAC4 ST6GALNAC6 A4GALT ST6GALNAC2 B3GALNT1 Glucocorticoid Receptor Pathway WP2880 FGFBP1 CUL1 POU5F1 PDE4B SEC14L1 MGAM TGFBR3 HSP90AA1 SNAI2 PRRG4 FGD4 DNAJC15 NR3C1 DNER CCL2 SPRY1 B3GNT5 ANGPTL4 SERPINB9 CCL20 THBD S100P SRGN ARL5B LRRC8A SERTAD2 STOM ALOX5AP CDKN1C CPEB4 TNS4 EPB41L4B AMIGO2 EDN2 PTGS2 TNFAIP3 BIRC2 NR1I2 JUN GADD45B BHLHE40 NFKB2 RXRA CAVIN2 PPP1R14C SPINK13 BIRC3 ACKR3 TSC22D3 ANKRD1 ADGRF4 ETNK2 KTN1 RGS2 NAV3 SLC26A2 ENC1 MFGE8 NR1I3 PMP2 CDC42EP3 PLK2 IL11 PTGES3 SCNN1A ZIC2 SLC19A2 GPR153 ABHD2 AKAP13 Glucuronidation WP698 UGT2B4 UGT2B10 UGT2B7 UGT2B17 UGT2B15 UGP2 UGT2B28 UGT2A3 UGT1A6 UGT1A7 UGT1A8 UGT1A10 UGT2A2 PGM1 UGT1A3 UGT1A1 PGM3 UGT1A4 PGM5 UGT1A5 UGDH HK1 PGM2 UGT1A9 UGT2A1 UGT2B11 Glutathione metabolism WP100 GGT2 GGTLC2 ANPEP OPLAH GSTA5 GGTLC1 IDH1 GPX3 GSTM1 GPX2 GGT1 GPX1 GSTT2 GGT5 LOC102724197 GCLM GSTA1 GCLC GSS GSR GSTM2 G6PD GPX4 Glycerolipids and Glycerophospholipids WP4722 PCYT1A DGAT1 GPAT4 PISD CHKB PNPLA3 CDS1 PTDSS1 GPAM DGAT2 CRLS1 ETNK1 CHPT1 PNPLA2 AGPAT4 PLD1 DGKZ PCYT2 PEMT PTDSS2 PLA2G1B CDIPT Glycerophospholipid Biosynthetic Pathway WP2533 LPIN2 CEPT1 PLA2G2A GPAT4 PGS1 CHKB PIP5K1A PI4K2A GPAT3 IPMK CRLS1 CHPT1 PTPMT1 MOGAT3 PCYT2 PIK3CG GNPAT CDS2 AGPS PTDSS1 PIK3CA PIK3CB PIK3CD GPAM GK LPIN1 GPAT2 GPD1 PEMT CDIPT Glycogen Synthesis and Degradation WP500 PHKG2 CALM3 PPP2R2A PPP2R2B HK3 UGP2 PHKG1 HKDC1 PPP2R1B AGL GYG2 PGM1 PYGB PPP2CA PPP2CB PYGL PYGM PPP2R1A PHKA1 PHKA2 PHKB HK2 PPP2R3B HK1 GYS2 GSK3B GYS1 GSK3A GBE1 GYG1 PPP2R2C CALM1 PPP2R3A PTPA PPP2R5A PPP2R5B PPP2R5C CALM2 PPP2R5D PPP2R5E Glycolysis and Gluconeogenesis WP534 TPI1 PGAM1 PGAM2 HK3 LDHAL6B MDH1 MDH2 PDHA1 ALDOC GCK GPI FBP1 LDHA ENO3 MPC1 ENO2 PFKP PKLR PKM FBP2 GOT2 GOT1 DLD DLAT PGK1 PGK2 PFKL PFKM ENO1 HK2 PC HK1 MPC2 LDHC ALDOA GAPDH SLC2A1 PCK1 ALDOB SLC2A3 SLC2A2 SLC2A4 SLC2A5 LDHB G6PC Glycolysis in senescence WP5049 PGK1 LDHA PRKAA1 TP53 GAPDH ENO1 PKM HK1 G6PD ALDOC RB1 Glycosaminoglycan degradation WP4815 GUSB HYAL4 HYAL1 HYAL2 HEXB HEXA HPSE GNS IDUA HGSNAT ARSB GALNS GLB1 IDS HPSE2 SGSH NAGLU Glycosylation and related congenital defects WP4521 MAGT1 ALG6 MPI MOGS ALG3 ALG1 ALG11 ALG8 GMPPB DPAGT1 ALG9 MGAT2 DOLK PMM2 TUSC3 B4GALT1 ALG12 ALG14 SRD5A3 DPM3 DPM1 ALG13 MPDU1 ALG2 DPM2 GPCRs, Class A Rhodopsin-like WP455 OXTR TRHR OR2S2 P2RY4 P2RY6 P2RY11 P2RY13 CCR2 EDNRA CCR1 OPN4 P2RY1 P2RY2 TBXA2R GPR87 RHO OR1D2 OR1F1 OR2C1 OR10H3 LTB4R GHSR CMKLR1 SUCNR1 OR2B3 OR7C2 OR2J3 OR10H1 OR7A5 OR10H2 EDNRB ACKR2 CCR8 ADORA1 ADORA2A CCR7 CCR6 ADORA2B CCR5 CCR4 OR11A1 CCR3 OPRD1 OPRK1 OPRL1 OPRM1 OPN1LW CHRM4 OR7C1 CHRM3 ADORA3 CHRM2 GPR83 HCAR1 OR2A4 PTGDR CHRM1 ADRA1D ADRA1B ADRA1A OR3A1 ACKR4 OR3A2 PTAFR NPFFR2 GPR171 ADRA2A ADRA2B ADRA2C ADRB1 PTGIR ADRB2 ADRB3 GALR1 CHRM5 PTGER1 PTGER2 PTGER3 NPY1R PTGER4 DRD5 NPY2R DRD4 DRD3 NPY5R DRD2 PTGFR C3AR1 DRD1 OR8D2 OR10A5 OR2AG1 FPR3 CNR2 FPR2 OR2D2 CNR1 FPR1 GPR68 OR7A10 GPR65 FSHR OR6A2 OR12D3 CXCR2 CXCR1 OPN1SW MTNR1A OR2H2 MTNR1B GRPR GALR3 GPR45 LPAR6 PTGDR2 HTR1E OPN3 HTR1D HTR1B HTR1A AGTR1 AGTR2 APLNR OR1C1 OR1A2 BDKRB1 BDKRB2 HRH3 NMUR2 OR2H1 SSTR1 NPY4R SSTR3 SSTR2 HTR7 HTR6 HTR5A F2RL2 F2RL1 HTR4 CYSLTR2 F2R HTR2C GPR75 HTR2B OR5V1 HTR2A HTR1F OR2B2 XCR1 GPR4 GPR3 CCR10 GPR1 OR1E1 OR1E2 OR1D5 CXCR4 RGL4 OR1A1 PRLHR CXCR3 NPBWR2 NPBWR1 GPR6 CXCR5 CCKAR CCKBR SSTR5 SSTR4 GALR2 GPR15 GPR12 F2RL3 GPR50 OR1G1 LPAR5 OR5F1 OR3A3 GPR22 ACKR3 GPR21 GPR20 OR8B8 GPR19 GPR18 GPR17 MAS1L GPR25 MCHR1 LPAR4 OR2J2 HCAR3 NPFFR1 GPR161 HRH2 CYSLTR1 CX3CR1 GPR32 GPR31 GPER1 HRH1 CCR9 GPR27 OR10A4 GPR35 GPR34 OR1I1 FFAR2 FFAR3 AVPR1A AVPR1B FFAR1 GPR39 AVPR2 MLNR C5AR2 GPR37 OR10J1 RRH OR1Q1 P2RY14 NTSR1 GPR63 CCRL2 MAS1 OR14J1 BRS3 P2RY12 GPR174 P2RY10 GPR85 GPR173 MC1R NTSR2 OR6B1 GPR37L1 HCRTR2 HCRTR1 OR2F2 NMUR1 OR2W1 NMBR OR7A17 OR2B6 OR2T1 OR2F1 LHCGR OR5I1 MC5R RABGAP1 GPR52 MC4R OR1D4 OPN1MW MC2R MC3R GPCRs, Class B Secretin-like WP334 SCTR VIPR1 ADGRE2 ADGRL1 ADGRL4 VIPR2 CRHR2 ADGRL2 CRHR1 GHRHR GLP2R GCGR ADGRE1 ADGRL3 GIPR GLP1R CALCR ADCYAP1R1 ADGRE5 PTH1R PTH2R LINC02210-CRHR1 ADGRG2 CALCRL GPCRs, Class C Metabotropic glutamate, pheromone WP501 GABBR2 GABBR1 GPRC5C GPRC5A GRM1 GRM8 GRM7 CASR GRM6 GRM5 GRM4 GRM3 GPRC5B GRM2 GPRC5D GPCRs, Other WP117 OR2H1 CELSR1 PROKR2 ADGRE2 SSTR2 HTR7 GPR88 ADRB2 LTB4R2 F2R OR6C2 GPR61 C5AR2 ADGRL3 RXFP3 HTR2A HTR1F OR1N1 DRD4 DRD3 NTSR1 OR5AC2 PTGFR OR1E1 P2RY11 VN1R1 P2RY13 TAAR5 EDNRA OR7E24 OR10A5 GRM1 CXCR3 GNRHR CNR1 OR2M4 CCKBR GRM8 GPR84 UTS2R S1PR1 GPR143 ADGRG1 TAAR2 ALG6 OR1F1 OR2A5 OR1G1 GPR183 ADGRL2 GHRHR FSHR HRH4 OR3A3 OR6C3 SMO OR8G1 CELSR2 CELSR3 ADORA2A CXCR2 GPR18 CCR5 CXCR1 GPR17 OR7A17 OR2B6 ADGRF5 OR2F1 GPR176 OR10A2 GRPR ADGRD1 GPR135 LGR6 GPR132 CHRM3 GPR162 GPR55 ADORA3 RXFP1 GPR62 CHRM2 GPR83 ADGRE3 OR2A4 MCHR2 ADRA1D ACKR1 ADGRV1 OR3A1 GPR40 Pathway WP3958 PLCB2 PLCB3 PKD1 PLCD3 PLCD1 PLCL1 PLCB1 PLCH1 GNA11 PLCE1 FFAR1 PLCZ1 PLCG1 PLCG2 ITPR3 H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity WP3969 TULP3 H2AFY PMAIP1 JAG1 CDK4 CCND1 CTNNB1 CSRP2 CDK8 CDH1 MED1 E2F1 SOX4 RB1 Hair Follicle Development: Organogenesis - Part 2 of 3 WP2839 NFKB1 CCND1 SMO EDA BMP4 CCND2 MYC CTNNB1 EDAR FGF1 GTPBP4 TP63 SHH CDH1 LAMA5 FZD1 LRP5 FOXI3 PDGFA WNT5A PDGFRA NCAM1 FGFR2 GLI1 RUNX2 INHBA GJB6 LEF1 ITGB1 SNAI1 PTCH1 GLI2 Head and Neck Squamous Cell Carcinoma WP4674 FADD RPS6KB2 NUMB CUL3 TGFBR2 STK11 NRAS TSC1 CDK6 CSMD3 FAT1 IGF1R RPS6 CDK4 CCND1 AJUBA CTNNB1 SESN1 EIF4EBP1 KEAP1 EIF4E GAB1 MAML1 NFE2L2 TERT PIK3R5 FKBP1A SESN2 CDKN2A CDKN1A CASP8 MTOR NOTCH1 AKT1 TSC2 BIRC2 AKT2 NOTCH2 E2F1 KRAS TRAF3 NFKB1 NFKB2 PRKAA1 VEGFA PRKAA2 RICTOR HRAS RPTOR TP63 RHEB EGFR PIK3CG PIK3R1 PIK3R2 MLST8 SMAD4 TP53 RELA FGFR2 ERBB2 PIK3CA FGFR3 PIK3CB PDPK1 FGFR1 DDIT4 PTEN AKT3 MAPKAP1 IRF6 REL RB1 Heart Development WP1591 HAND1 BHLHE40 IRX4 PTPN11 HAND2 VEGFA VEGFC NFATC1 VEGFB NFATC2 FGF8 NKX2-5 FOXC1 BMP10 BMP2 FOXC2 BMP4 CTNNB1 TBX2 HEY1 BMPR1A SHH SRF BMPR2 SMYD1 FOXH1 MEF2C GATA6 GATA4 FOXA2 SMAD1 MAPK1 ISL1 SMAD4 ERBB3 TBX20 HEY2 FGF10 NOTCH1 NFATC3 NFATC4 TBX5 TBX1 PITX2 Hedgehog Signaling Pathway Netpath WP47 KIF7 SAP18 PTCH2 STK36 SIN3A IHH GLI1 SMO GRK2 SUFU SHH ARNTL DHH GLI3 GLI2 PTCH1 Hedgehog Signaling Pathway WP4249 CUL3 HHIP SMURF2 BOC TPTEP2-CSNK1E LRP2 CSNK1A1L SPOPL SMO CCND1 GRK2 BCL2 CSNK1G3 GRK3 CCND2 CSNK1G2 CSNK1E CSNK1D SUFU CSNK1A1 SHH CSNK1G1 SPOP KIF3A CDON KIF7 PTCH2 EVC2 EVC SMURF1 GPR161 GLI1 IHH FBXL17 PRKACA PRKACB PRKACG GAS1 ARRB1 ARRB2 DHH GLI3 PTCH1 GLI2 Hematopoietic Stem Cell Differentiation WP2849 ZNF835 KITLG NFATC2 FOS IL3 GATA2 GATA1 RHOH IL1B ACVR1B ITGA2B LMO2 MXI1 MYB KCNH2 CIITA ITGB3 MUC1 LYL1 CXCR4 TRIM29 RIOK3 TPO HMGN5 IL6 IL5 FLI1 LEF1 GYPA FOSB NOTCH1 KLF1 NFE2 VAV1 THRB ABO TNXB CSF3 EPO SEC14L2 CSF2 CSF1 TRAF3IP3 HES6 SPI1 NCKAP1L IL1A PIM1 RUNX1 CBFA2T3 IRF5 STAT5A IKZF1 CD34 GP9 Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex WP3657 ZFX SMARCA4 SMAD4 TERF2 GABPA GZMB EP300 ETV6 MCL1 ATM DNMT3B PTEN DNMT3A BCL2 DNMT1 BCL2L1 GABPB1 CREBBP FLT3 FOXO3 Heme Biosynthesis WP561 ALAD ALAS1 ALAS2 UROD FECH PPOX HMBS UROS CPOX Hepatitis B infection WP4666 FADD CREB5 TGFB3 TGFBR1 TGFBR2 EP300 TGFB1 TGFB2 BCL2 MYC FAS FASLG BID MAVS TYK2 MAP3K7 ARAF IRAK4 MAP3K1 MYD88 TRAF3 IKBKE TRAF6 TIRAP STAT2 STAT1 STAT4 SOS1 IRF3 STAT3 HRAS TICAM1 ATP6AP1 IRAK1 PIK3R1 PIK3R2 SMAD2 SMAD3 MAPK12 RELA SMAD4 IKBKB PTK2B PIK3CA PIK3CB PIK3CD MAP2K6 MAP2K7 DDB2 DDB1 CREB3L3 AKT3 STAT5B MAPK11 STAT5A SOS2 MAPK9 MAP2K4 IRF7 MAPK10 STAT6 CREB3 MAPK13 MAP2K1 MAP2K2 MAP2K3 PRKCG TNF NFATC1 NRAS SLC10A1 NFATC2 FOS CREB1 IFNA5 IFNA4 IFNA2 IFNA1 JAK1 JAK2 BRAF JAK3 DDX3X APAF1 PRKCA PRKCB CASP3 YWHAQ TAB1 TLR4 TLR3 MAPK1 MAPK3 PCNA CREB3L1 YWHAZ CREB3L2 TICAM2 IFNA21 IFNA17 TLR2 IFNA16 IL6 TBK1 IFNA14 IFNA13 CDKN1A CHUK IFNA10 CASP8 ATF6B IFNA8 CREBBP CASP9 IFNA7 ATF2 CASP10 CREB3L4 IFNA6 AKT1 NFATC3 AKT2 NFATC4 CYCS YWHAB SRC KRAS JUN NFKB1 IFIH1 DDX58 BAD HSPG2 BIRC5 GRB2 MAPK14 IFNB1 CXCL8 ELK1 IFNAR1 MAPK8 PIK3R3 EGR2 VDAC3 CASP12 RAF1 BAX TAB2 EGR3 ATF4 IKBKG MMP9 Hepatitis C and Hepatocellular Carcinoma WP3646 TGFBR1 PTPN11 PODXL TGFB1 CCND1 JAK1 BRCA1 MYC FASLG BCL2L1 CASP3 NOS2 RRM2 HIF1A MAPK3 VAV2 IL6R IL6 CD44 CDKN1A CASP7 LEF1 CASP9 AKT1 PTGS2 JUN NFKB1 VEGFA UCHL1 SOS1 STAT3 COL4A2 BIRC3 HNF1A BIRC5 GRB2 MAPK14 CXCR1 FRZB CXCL8 E2F2 MAPK8 RAC1 MYOF SMAD3 TP53 SMAD4 CTTN MMP1 Hereditary leiomyomatosis and renal cell carcinoma pathway WP4206 PDHB PDK1 PRKAG1 HIF1A NFE2L2 CUL3 PRKAA1 SLC11A2 VEGFA TP53 PRKAB1 PDHA1 RPS6 PDHA2 EGLN1 LDHA SLC2A1 ACACA ACACB KEAP1 Hfe effect on hepcidin production WP3924 HJV BMP6 TMPRSS6 HAMP ID1 HFE SMAD7 HIF1A and PPARG regulation of glycolysis WP2456 TPI1 GPAT3 HIF1A LDHA GAPDH SLC2A1 GPD1 PPARG Hijack of ubiquitination by SARS-CoV-2 WP4860 CUL2 NAE1 ZYG11B UBA3 CBFB ELOC RBX1 ELOB Hippo-Merlin Signaling Dysregulation WP4541 IGF1R CCND1 FOXM1 MYC AJUBA CDH1 RBX1 TAZ LATS1 ITGA11 PDGFRA SAV1 INSR MET CDH2 CDH20 LIN28B HRAS KIT FLT4 FLT3 FLT1 PDGFRB ITGA6 PRKAR1A KDR MST1 PLCB4 ITGA1 PRKAR1B PAK1 PRKAR2A ITGA2 CTNNA1 CDH12 CTGF CDH10 NTRK1 CDH9 NTRK2 CDH8 CDH7 CDH6 DDB1 CDH5 CDH4 CDH3 PRKACA PRKACB PRKACG CDH11 PAK3 CUL4A ITGA9 ITGAD TEAD4 ITGAE NF2 TEAD1 ITGAL NRAS ITGAM TEAD3 PAK5 PAK2 NGFR CDH18 CDH17 YY1AP1 CTNNB1 CDH16 CDH15 CDH13 PRKAR2B ITGA2B STK3 ITGA3 ITGA4 PAK4 ITGA5 ITGA7 TEK ITGB3 ITGB4 TEAD2 AMOT ITGB5 ITGB6 ITGB7 CDH24 CDH22 LATS2 PPP1R14A CD44 ITGAV PPP1CB PPP1CC ITGAX ITGB1 ITGB2 PTK2 PPP1R12A KRAS VGLL4 CDH19 CSF1R ITGB8 EGFR DCAF1 PPP1CA FGFR4 FGFR2 FGFR3 FGFR1 ITGA8 ITGA10 EPHA2 BUB1B-PAK6 PAK6 CXCL10 Hippo-Yap signaling pathway WP4537 LATS1 TEAD2 MAP4K1 TEAD4 NF2 MST1 MAP4K2 MAP4K4 TEAD1 RASSF1 TEAD3 STK38L LATS2 MAP4K3 YY1AP1 TNIK STK3 SAV1 MINK1 NDRG1 YWHAQ TAZ CXCL10 Histone Modifications WP2369 SMYD4 KMT2A SMYD3 HIST1H4I DOT1L EZH2 KMT5A EZH1 SETD5 EHMT1 PRDM2 EED HIST1H3F SETD1A SETD3 NSD1 HIST2H3C SETBP1 SUV39H1 SUV39H2 SETDB1 HIST4H4 SETD2 HIST1H3I HIST1H3G HIST1H3C HIST1H3E HIST1H3B HIST1H4A HIST1H3J HIST1H3H HIST2H3A SETD1B SETD4 H3F3B H3F3A HIST1H3A HIST1H3D HIST2H3D SETDB2 SMYD2 KMT5C SMYD1 KMT2B AEBP2 KMT2E SETD6 HIST1H4H HIST1H4B HIST1H4J HIST1H4C HIST1H4G HIST1H4E HIST1H4L EHMT2 HIST1H4F HIST1H4K KMT2D HIST1H4D ASH1L SETD7 KMT5B SETD9 SET SMYD5 KMT2C SETMAR Homologous recombination WP186 MRE11 NBN RAD52 RAD54B ATM POLD3 BRCA2 RPA1 POLD1 POLD2 RAD51 RAD50 POLD4 Host-pathogen interaction of human coronaviruses - apoptosis WP4864 FADD MAPK12 TNF BAX MCL1 BAD BCL2L11 BCL2 CASP7 FASLG BBC3 BCL2L1 CASP8 MAPK14 CASP9 MAPK11 AKT1 APAF1 BID CASP3 MAPK13 Host-pathogen interaction of human coronaviruses - autophagy WP4863 ATG5 RB1CC1 BECN1 PIK3R4 PIK3C3 ATG13 ATG3 ATG16L1 ATG12 WIPI1 ATG10 ATG16L2 ATG4A MAP1LC3A MTOR ZFYVE1 ULK1 ULK2 ATG7 Host-pathogen interaction of human coronaviruses - interferon induction WP4880 IKBKE TRAF3 TRAF6 NFKB1 IFIH1 NFKBIA STAT2 STAT1 IRF3 FOS DDX58 TICAM1 JAK1 TLR7 MAPK14 IFNAR2 IFNAR1 EIF2AK2 MAPK8 OAS3 MAVS IRF9 TYK2 MAP3K7 IKBKB TBK1 OAS1 OAS2 CHUK RIPK1 IKBKG MYD88 JUN Host-pathogen interaction of human coronaviruses - MAPK signaling WP4877 MAP3K9 RPS6KA3 MAP3K10 RPS6KA2 MAP3K11 FOS RPS6KA1 BCL2 MAPK14 MAPK8 IFITM3 EIF4E MAPK1 MAPK12 MAPK3 RAF1 IFITM2 JUNB MAP2K6 MAP2K7 BST2 ATF2 MAP3K1 MAPK11 MAPK9 MAP2K4 MAP3K4 MAPK10 MAPK13 MAP2K1 DDIT3 MAP2K2 MAP2K3 JUN IFI27 IFITM1 Hypertrophy Model WP516 NR4A3 DUSP14 VEGFA IL1A IFRD1 MSTN CYR61 JUND ANKRD1 IFNG ADAM10 ATF3 IL1R1 HBEGF MYOG ZEB1 WDR1 EIF4EBP1 IL18 EIF4E Hypothesized Pathways in Pathogenesis of Cardiovascular Disease WP3668 LTBP1 TGFBR1 LTBP2 TGFBR2 TGFBR3 NR2C2 FBN3 MAPK14 FBN2 FBN1 MAPK8 POSTN SERPINE1 MAPK1 SMAD2 MAPK3 SMAD3 SMAD4 SHC1 ENG CTGF AGTR1 ANGPT2 FLNA RUNX2 Hypothetical Craniofacial Development Pathway WP3655 ARHGAP29 TGFB3 RHOA TP63 IRF6 TFAP2A WNT1 ID signaling pathway WP53 PAX2 PAX5 SREBF1 ID2 ID1 CDK2 ELK4 ELK3 ELK1 ID3 CCNE1 MYOD1 RBL1 RBL2 RB1 PAX8 IL-1 signaling pathway WP195 PTPN11 MAPKAPK2 MAP3K14 HSPB2 TOLLIP IL1RAP IL1R1 IL1B PLCG1 CCL2 TAB1 MAPK1 UBE2N MAPK3 MAP3K7 UBE2V1 PRKCZ MAP3K2 ECSIT CHUK IRAK4 ATF2 AKT1 MAP3K1 MAP3K3 MYD88 JUN TRAF6 NFKB1 NFKBIA NFKBIB PELI2 PELI1 MAPK14 MAPK8 IRAK1 IRAK2 PIK3R1 PIK3R2 RELA IL1A IKBKB TAB3 TAB2 MAP2K6 MAP2K7 IKBKG MAPK9 MAP2K4 SQSTM1 REL MAP2K1 IRAK3 MAP2K2 MAP2K3 IL-10 Anti-inflammatory Signaling Pathway WP4495 JAK1 IL6 STAT2 IL10RB STAT1 BLVRA IL10RA BLVRB STAT3 IL10 IL1A HMOX1 IL-18 signaling pathway WP4754 CCL4 FADD CLDN12 CCL5 KRT31 LTB BCL2 FAS FASLG BCL2L1 SPON1 CCL3 CCL2 CNTN2 NOS2 KCNH2 CCL18 CCL20 CCL19 AARS TNFRSF11B RGS16 CLDN15 CLDN1 MYD88 NR0B2 ABCF1 TSHZ1 RXRB STK40 ARL4D FOXN3 RPTOR TBX21 IRAK1 MYH6 PYGB ACOD1 MYH7 CCDC9 ACACB IRF1 PIK3R1 ACADS SDC4 TMSB4X RELA ITM2C CPT1A IKBKB ARF6 ARG1 PARP1 PTEN MAP2K7 FN1 CLDN3 LARS2 CLDN4 IRF6 TRPM7 MAPK9 REL CD36 NPPA NPPB UGT2B10 CXCL16 TNF TNFAIP2 S1PR4 FOS BIN1 IL2RA PRM1 HSPB1 CTNNB1 IL1B ARFGAP2 ITGA2B EEF2 CASP3 GRIN2B DEK TNFRSF1A ACTA1 NR1H3 ACTA2 RFX5 COX17 TICAM2 IL6 ALS2 CHUK CASP8 IL37 CD83 TNFAIP3 ABHD16A PTGS2 IL18BP GRM7 NFATC4 SEMA6C NFKB1 NFKB2 NFKBIA GPAT4 PLA2G7 NFKBIE PTMS COL3A1 IL17RC MUM1 LMNB2 CXCL3 CXCL2 IFNG IL9 COL1A2 ZBTB7A CXCL8 COL1A1 ZNF219 CD81 TF NACA TP53 ANP32A MMP13 IL13 ENO1 ULBP2 IL12B CEBPB IMP3 RAE1 RASA3 GSK3B PHF20 RUNX2 PPP1R13L NOX1 IL10 MMP1 MMP2 MMP3 ZNF143 LRRFIP1 MMP8 MMP9 RPS6KB1 NCAPH2 IL18R1 TNIP3 LONP2 CENPB MEPCE HOXD8 MMP14 BTG2 NCF2 BID PTPN7 MEF2A TACR1 IL18RAP CDK5R2 SNTB1 MAP3K7 HCAR2 CETP FBXW7 TGM2 STMN1 EPB41 TMEM165 PRCC KIFC3 ARFGAP1 TRAF6 PRKAA1 NFKBIZ ICAM1 MTCH1 RND2 TRAF1 CCNA2 CA11 BMP2 ELAVL1 NSMF TRPC4AP ZC3H12A HPS1 ZDHHC7 LCK TIMP1 CCNB2 TIMP3 SLC4A7 TNFSF11 WISP1 MBTPS1 HDAC3 ECH1 ADIPOQ HADH PPT2 NCF1 EPS8 BPGM KLF2 CFLAR PRKCD PKN1 KITLG NR4A1 SOCS3 HMOX1 GATA1 HSPB8 SP1 PLCG1 PRKCA PRKCB PLD1 KLC1 TOMM40 PIGT STOML1 FAM186B MAPK1 PLOD3 MAPK3 BAZ1B BSG RANGAP1 UCK1 APBA2 CRYGC B2M NRN1 SLC12A3 FAM110A CYCS SEMA6D IL18 JUN IER3 USP5 VEGFA SPP1 HDGF RUSC1 BIRC3 BAD FUT1 DES RPS11 SYT10 ADAMTS5 CCL1 BAX ZNF444 PTX3 CSN2 NDUFC1 UGGT1 GRN ATF3 PTPRZ1 IL-2 signaling pathway WP49 RPS6KB2 PTPN11 RPS6KB1 SYK STAT1 SOS1 STAT3 FOS HRAS IL2RG IL2RB SOCS3 RPS6 IL2RA JAK1 IL2 BCL2 CCND2 MYC JAK3 GRB2 CRKL LCK FOXO3 PIK3R1 NMI MAPK1 MAPK3 SHC1 RAF1 CISH PTK2B FYN STAT5B AKT1 CBL MAPT STAT5A GAB2 MAP2K1 MAP2K2 JUN IL-3 signaling pathway WP286 PTPN11 IL3RA FOS IL3 TGFB1 JAK1 BCL2 JAK2 BCL2L1 PTPN6 INPP5D YWHAQ MAPK1 MAPK3 LYN HCK IL5RA AKT1 CD69 YWHAB SRC VAV1 JUN SYK SOS1 ENPP3 STAT3 HRAS BAD RAPGEF1 GRB2 CRKL CXCL8 CCR3 MAPK8 CSF2RB PIK3R1 PIK3R2 SHC1 RAF1 PIK3CD FYN CD86 PRKACA STAT5B STAT5A CBL GAB2 MAP2K1 IL-4 signaling pathway WP395 SOCS1 PTPN11 RPS6KB1 FOS EP300 IL2RG SOCS3 GATA3 JAK1 JAK2 JAK3 PTPN6 INPP5D TYK2 IRS2 MAPK1 MAPK3 NFIL3 FES FLNA CHUK IL4R IL4 ATF2 AKT1 NFKB1 DOK2 NFKBIA STAT1 SOS1 STAT3 BAD BIRC5 GRB2 MAPK14 ELK1 PIK3R1 PIK3R2 RELA SHC1 SOCS5 IKBKB CEBPB PIK3CA CEBPA PIK3CD HRH1 STAT5B MAPK11 CBL STAT5A STAT6 GAB2 IRS1 IL-5 signaling pathway WP127 RPS6KB2 RPS6KB1 PTPN11 SYK STAT1 SOS1 STAT3 FOS RPS6KA1 RPS6 JAK1 BTK JAK2 IL2 BCL2 MYC GRB2 ELK1 FOXO3 CSF2RB PIK3CG PIK3R1 PIK3R2 MAPK1 MAPK3 SPRED1 LYN SHC1 RAF1 GSK3B GSK3A IL5RA STAT5B STAT5A AKT1 MAPT MAP2K1 KRAS MAP2K2 JUN IL-6 signaling pathway WP364 PRKCD RPS6KB1 PTPN11 STAT1 SOS1 STAT3 HDAC1 SOCS3 BAD JAK1 JAK2 GRB2 BCL2L1 NCOA1 PRDM1 RAC1 NLK GAB1 IRF1 TYK2 PIK3R1 TIMP1 PIK3R2 MAPK1 MAPK3 SHC1 VIP MAP3K7 HCK IL6ST IL6R NR2F6 AGT JUNB GSK3B IL6 CRP CREBBP AKT1 MAP2K4 MAP2K1 MAP2K2 VAV1 IL-7 signaling pathway WP205 STAT1 STAT3 IL2RG BAD CCND1 JAK1 IL2RA MYC JAK3 BCL2L1 IL7R PIK3R1 PIK3R2 MAPK1 MAPK3 IL7 PTK2B GSK3B FYN CDKN1B STAT5B STAT5A AKT1 MAP2K1 MAP2K2 IL-9 signaling pathway WP22 PIK3R1 PIK3R2 MAPK1 MAPK3 STAT1 STAT3 IL2RG IL9R JAK1 JAK3 GRB2 IL9 CDK9 STAT5B STAT5A MAP2K1 MAP2K2 IL1 and megakaryocytes in obesity WP2865 NFKB1 SELENBP1 PLA2G7 ICAM1 NLRP3 FCER1A F2R IFNG F2 IL1R1 IL1B CCR3 CCL2 IRAK1 HBEGF TIMP2 TIMP1 PIK3CA S100A9 TLR2 TLR1 MMP9 IL18 MYD88 IL17 signaling pathway WP2112 IL17RE TRAF3 TRAF6 NFKB1 IL17F NFKBIB STAT3 IL17RA IL17RC MAP3K14 IL17D IL25 JAK1 TRAF3IP2 JAK2 IL17RB IL17C SP1 IL17RD MAPK1 MAPK3 RELA MAP3K7 IKBKB CEBPD PIK3CA CEBPB GSK3B IKBKG AKT1 IL17B IL17A Imatinib and Chronic Myeloid Leukemia WP3640 ABL1 ABCB1 LYL1 PDGFRA PIM2 SPRED2 PIM1 KIT CSF1R NOP2 MYC CDKN1B FLT1 BCR ABCG2 PDGFRB SKP2 GAB2 FOXO3 GADD45A Immune response to tuberculosis WP4197 SOCS1 TAP1 TYK2 PTPN2 STAT2 STAT1 PSMB8 PIAS1 MED14 IFI35 IFNGR2 JAK1 OAS1 IFNGR1 IFIT3 JAK2 IFIT1 IFNAR2 IFNAR1 MX1 IRF9 IRF1 IFITM1 Inflammatory Response Pathway WP453 IL2RG IL2RB COL3A1 LAMB2 IL2RA IL2 LAMC1 IFNG LAMC2 COL1A2 COL1A1 ZAP70 CD40 LCK CD40LG LAMA5 LAMB1 TNFRSF1A THBS1 TNFRSF1B THBS3 IL5RA FN1 IL5 IL4R CD28 IL4 CD80 CD86 VTN Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells WP4301 RRAS2 HGS MAPK1 MAPK3 RAF1 NRAS RAB27A HRAS HNRNPH1 BRAF ARAF MRAS RRAS PDCD6IP RAB5C RAB5A KRAS RAB5B Initiation of transcription and translation elongation at the HIV-1 LTR WP3414 NFKB1 NFKBIA NFATC1 NFATC2 EP300 HDAC2 HDAC1 NELFB SUPT5H HEXIM1 HDAC7 SP1 PPP3CC HDAC4 HDAC8 PPP3R1 PPP3R2 NELFE HDAC5 SUPT4H1 PPP3CA RELA HDAC9 PPP3CB HDAC3 CDK9 CREBBP NELFCD NFATC3 NELFA NFATC4 CCNT1 Insulin signaling in adipocytes (diabetic condition) WP3635 TBC1D4 RPS6KB1 MTOR INSR AKT2 IRS1 SLC2A4 RPS6 Insulin signaling in adipocytes (normal condition) WP3634 TBC1D4 RPS6KB1 MTOR INSR AKT2 SLC2A4 IRS1 RPS6 Insulin Signaling WP481 RPS6KA3 SOCS1 MAP3K9 RPS6KA2 SNAP23 MAP3K10 RPS6KB2 RPS6KB1 MAP3K11 PTPN11 MAP4K1 MAP4K5 RRAD MAP4K3 IGF1R RPS6KA1 MAP3K6 STXBP4 EHD1 INPP4A FOXO3 FOXO1 EIF4EBP1 INPPL1 EIF4E GAB1 SHC2 IRS2 PTPRF MAP3K7 ARHGAP33 SLC2A1 MAP3K1 MAP3K3 INSR MAP3K4 MAP3K5 SLC2A4 FLOT2 TBC1D4 PIK3C2A PRKAA1 PIK3C2G ENPP1 PRKAA2 PIK3C3 SOS1 HRAS ARF1 TRIB3 SGK2 RHEB PIK3CG PIK3R1 PIK3R2 MAPK12 PFKL PFKM MYO1C IKBKB RHOQ PIK3CA RPS6KA5 ARF6 PIK3CB PDPK1 SGK3 PIK3CD PTEN MAP2K5 MAP2K6 MAP2K7 STX4 MAPK11 SOS2 STXBP1 MAP2K4 MAPK9 MAPK10 IRS1 MAPK13 STXBP3 STXBP2 REG1A CAP1 MAP2K1 MAP2K2 MAP2K3 PRKCD CYTH3 PRKCH PRKCI TSC1 FOS SOCS3 RHOJ MAP3K14 PRKCA PRKCB FLOT1 KIF5B XBP1 MAPK1 MAPK3 RPS6KA4 PIK3R4 MAPK4 MAP4K2 MAPK6 MAPK7 SORBS1 PRKCZ RPS6KA6 GYS2 GYS1 MAP3K2 GYG1 MTOR MINK1 PRKCQ AKT1 TSC2 SHC3 AKT2 RAB4A PPP1R3A JUN RAC2 MAP4K4 MAP3K12 IRS4 CBLC RAPGEF1 GRB14 GRB10 GRB2 MAPK14 CRK ELK1 EHD2 SRF MAPK8 SGK1 PIK3R3 VAMP2 EGR1 RAC1 KIF3A PTPN1 SHC1 RAF1 LIPE MAP3K13 GSK3B MAP3K8 GSK3A SH2B2 CBL CBLB SNAP25 Integrated breast cancer pathway WP1984 FADD TGFBR1 SMARCA4 TGFBR2 EP300 USP21 AHR ATM NOXA1 CCND1 BCL2 CDC25A MYC CDC25B GDI1 PPP4R3B CSNK1D CDC42 RALGAPA1 CDH1 BID RALA FOXO1 TPR ZMYND8 ERAL1 BLM CYP19A1 APOBEC3G AR ARAF RRAS E2F1 MSH6 RHO PIGR ABL1 WEE1 STAT1 PIAS1 MDM2 EDAR LGALS13 CHEK1 BMPR1A BMPR2 RHEB CHEK2 RAD50 SMAD1 MRE11 PIK3R2 SMAD2 SMAD4 NCOA3 PAK1 HMGCR PTEN ZNF655 ANXA1 ATR RAD54L PKIA IRS1 GADD45A TRADD AURKA STK11 TSC1 CREB1 RASGEF1A CDK7 PLK3 FAU SMAD6 SMAD7 CCNB1IP1 CDK4 BRCA1 JAK1 CDK2 BRAF CTNNB1 BRCA2 RASGRP3 ALKBH1 SP1 NF1 DHTKD1 USP38 CASP3 TAB1 XRCC3 MAPK1 MYT1 FOSL1 FER SIRT1 RAP1A CHUK CASP8 JAKMIP1 CASP9 FOSL2 MTOR PLK1 AKT1 TSC2 KRAS JUN ITPKC UBE2F NFKB1 VEGFA PHB ESR1 HIPK2 HDAC1 BACH1 BAD RPP38 IMPA1 BAK1 FILIP1 DCAKD NAB1 USP15 MAX MAP3K7CL RAC1 EGFR PML TFPI CERK TP53 MAP3K13 BARD1 BAX GSK3A PPP4R3A GRN ATF1 ZMIZ1 MYCBP2 NUP85 MMP1 RAD51 MSH2 ODC1 DAG1 USP16 RB1 Integrated Cancer Pathway WP1971 STAT1 ATM BACH1 MDM2 CDK4 NOXA1 BAD BRCA1 JAK1 CDK2 BCL2 CDC25A MYC CDC25B CHEK1 CASP3 CHEK2 RAD50 MRE11 POU2F1 SMAD2 SMAD3 TP53 CDKN2B BARD1 BAX PTEN CDKN1B BLM ATF1 CDKN1A BBC3 CDK1 CASP8 CASP9 ATR MMP1 PLK1 AKT1 MSH2 MAP3K5 E2F1 RB1 MSH6 Integrin-mediated Cell Adhesion WP185 CDC42 ITGA11 ROCK2 PXN ARAF MYLK2 RHO SOS1 HRAS ROCK1 ITGA6 CAPN9 PIK3R2 MAPK12 PAK1 ITGA1 ITGA2 PDPK1 MAP2K5 MAP2K6 SELENOP AKT3 CAPN1 CAPN2 CAPN3 MAPK10 CAPNS1 CAPN6 MAP2K1 MAP2K2 MAP2K3 PAK3 ITGA9 ITGAD ITGAE ITGAL ITGAM PAK2 BRAF VAV3 ITGA2B GIT2 ITGA3 ITGA4 PAK4 ITGA5 ITGA7 ITGB3 MAPK1 ITGB4 MAPK4 VAV2 ITGB5 MAPK6 ITGB6 MAPK7 SORBS1 ITGB7 TLN1 RAP1A RAP1B ITGAV AKT1 SHC3 AKT2 ITGAX CAPN5 ITGB1 ITGB2 VASP PTK2 SRC BCAR1 TNS1 RAC2 RAC3 ARHGEF7 RAPGEF1 GRB2 MYPN ILK CRK DOCK1 ITGB8 VCL CAV1 CAV2 CAV3 RAC1 ZYX SHC1 RAF1 CAPN11 FYN CSK CAPN7 ITGA8 CAPN10 ITGA10 BUB1B-PAK6 PAK6 Interactions between immune cells and microRNAs in tumor microenvironment WP4559 SOCS1 TGFB3 TRAF6 NFKB1 CCL5 NFKB2 TGFBR2 STAT3 IL2RG IL2RB TGFB1 TGFB2 IL2RA TLR7 CD274 CCL2 TLR4 PDCD1 CTLA4 IL4R CD80 IRAK4 TLR8 IL4 CD86 STAT6 PIAS3 CXCL10 Interactome of polycomb repressive complex 2 (PRC2) WP2916 ELL MORC3 MTF2 BCLAF1 SUZ12 RBBP4 STK38 SETX TRIM35 EZH2 EZH1 EED JARID2 RBBP7 THRAP3 AEBP2 Interferon type I signaling pathways WP585 SOCS1 RPS6KB1 PTPN11 CREB1 SOCS3 RPS6 JAK1 EIF4B EIF4A1 PTPN6 EIF4EBP1 EIF4E IRF9 TYK2 IRS2 RPS6KA4 PDCD4 RAP1A MTOR MAP3K1 PTPRC VAV1 STAT2 STAT1 PIAS1 STAT4 STAT3 RAPGEF1 CRKL MAPK14 CRK IFNAR2 RPTOR IFNAR1 ZAP70 RAC1 LCK RACK1 PIK3R1 PIK3R2 MLST8 PRMT1 RPS6KA5 PIK3CD MAP2K6 FYN CBL MAPKAP1 STAT5A GAB2 IRS1 REL MAP2K3 PIAS3 Interleukin-1 Induced Activation of NF-kappa-B WP3656 NFKB1 TRAF6 AJUBA UBE2N TIFA UBE2V1 IL1A IRAK1 SQSTM1 PRKCZ Interleukin-11 Signaling Pathway WP2332 PTPN11 RPS6KB1 STAT1 PIAS1 STAT3 CREB1 HRAS SOCS3 ICAM1 TGFB1 RPS6KA1 IBSP RPS6 JAK1 JAK2 BIRC5 BCL2 GRB2 BGLAP TYK2 PIK3R1 PIK3R2 MAPK1 MAPK3 RELA RAF1 ITGA2 IKBKB FES IL6ST PDPK1 IL11RA RUNX2 FYN IL11 ATF1 CHUK YES1 AKT1 PTPA SRC MAP2K1 MAP2K2 PIAS3 Intracellular trafficking proteins involved in CMT neuropathy WP4856 RAB4B MTMR2 SBF2 GDAP1 HSPB1 FGD4 HSPB8 LRSAM1 RAB7A NDRG1 EGR2 LITAF NEFL RAB11A PMP22 FIG4 RAB25 RAB11B KIF1B DNM2 RAB3A RAB3B SH3TC2 MPZ RAB4A RABAC1 MFN2 Intraflagellar transport proteins binding to dynein WP4532 WDR34 IFT22 DYNLT3 DYNLT1 DYNLL1 IFT140 IFT27 DYNC1I2 IFT80 DYNC1I1 DYNC1H1 DYNLRB2 DYNLRB1 DYNC1LI1 IFT122 DYNC2H1 DYNLL2 HSPB11 IFT46 TCTEX1D2 WDR19 DYNC2LI1 IFT43 WDR60 IFT81 DYNC1LI2 WDR35 Irinotecan pathway WP229 ABCC1 CES1 BCHE CYP3A5 CYP3A4 UGT1A9 ABCC2 UGT1A10 CES2 ABCG2 UGT1A1 NPC1 SLCO1B1 Iron metabolism in placenta WP2007 HEPHL1 ACO1 TFRC SLC11A2 TFR2 HAMP TF FTH1 SLC40A1 MCOLN1 STEAP3 IREB2 Joubert Syndrome WP4656 BBS5 PDE6A KIAA0586 PDE6D RPGRIP1L ATM BBS9 DVL1 CC2D2A TTC8 SUFU SHH CCP110 MYO5A TMEM138 MYO6 DVL3 PDE6B NPHP4 CEP41 BBS7 FLNA INPP5E RAB3IP INVS TCTN1 CETN2 ARL2 CETN1 TCTN3 MTOR ARL3 PDE6G PIBF1 TMEM216 ARR3 CSPP1 PCM1 AHI1 RAB8A ZNF423 CPLANE1 NEK8 TMEM17 CEP164 CEP97 ANKS6 PCNT RHEB RAD50 TMEM237 NPHP1 CEP290 CEP120 MRE11 RP2 TMEM67 CEP104 UNC119 ARL13B PARP1 TMEM231 BBS1 OFD1 BBS2 KAT5 B9D1 RHOA BBS4 ARMC9 NPHP3 NIN B9D2 ATF4 TCTN2 MKS1 Kallmann's Syndrome WP5074 MAPK1 PTPN11 SOX10 PROKR2 SEMA3E OTX2 NEUROG1 FGF8 FRS2 PIK3CA FGFR1 PLXND1 GRB2 PROK2 TMEM98 GNRH1 MYRF PRKCQ AKT1 ANOS1 CHD7 ASCL1 MAP2K2 OLIG2 Kennedy pathway from sphingolipids WP3933 PCYT1A CEPT1 PCYT1B PISD CHKB PTDSS1 ETNK1 ETNK2 CHPT1 SGPL1 PCYT2 PEMT PTDSS2 CHKA Ketogenesis and Ketolysis WP4742 UCP2 ACAT1 CPT2 BDH1 SLC16A1 SLC25A20 SLC2A1 OXCT1 Kisspeptin/kisspeptin receptor system in the ovary WP4871 PRKCD PRKCE PDK1 NFKB1 PRKCG STAR PRKCH NRAS CYP11A1 HRAS FSHR HSD3B1 KISS1 PRKCA PRKCB PIK3CG BMP15 PLCB2 MAPK1 MAPK3 PLCB3 PLCB4 RAF1 GDF9 PLCB1 PIK3CA PIK3CB PIK3CD AMH KISS1R PRKCQ AKT1 AKT2 ARRB1 MAP2K1 ARRB2 MMP9 MAP2K2 KRAS Kit receptor signaling pathway WP304 RPS6KA3 SOCS1 PTPN11 RPS6KB1 KITLG TEC FOS EP300 RPS6KA1 SNAI2 RPS6 BCL2 JAK2 TBX2 PLCG1 PRKCA PTPN6 PRKCB INPP5D FOXO3 MAPK1 MAPK3 LYN MATK JUNB AKT1 MAPT SOCS6 SRC VAV1 STAT1 SOS1 STAT3 HRAS BAD KIT BTK GRB10 GRB7 DOK1 GRB2 CRKL MAPK14 CRK MAPK8 PIK3R1 PIK3R2 MITF SHC1 RAF1 SH2B2 FYN STAT5B CBL STAT5A GAB2 SNAI1 MAP2K1 MAP2K2 Kynurenine Pathway and links to Cellular Senescence WP5044 TLR4 KMO AFMID TP53 KYNU TNF IL1R2 ACMSD QPRT HAAO IDO2 AHR EIF2AK4 IFNG EIF2AK1 CDKN1A AADAT IFNB1 IDO1 KLF5 NOS1 TDO2 FOXO1 LDLRAD4 and what we know about it WP4904 TGFBR1 SMAD2 TGFBR2 LDLRAD4 PMEPA1 NEDD4 ATG16L1 Leptin and adiponectin WP3934 PRKAG1 PRKAA1 PRKAB1 ADIPOR2 CPT1A ADIPOQ LEP LEPR ADIPOR1 ACACA Leptin Insulin Overlap WP3935 PIK3CG SOCS1 IRS2 STAT3 SOCS3 IRS4 PDPK1 JAK2 SOCS2 INS AKT1 PIK3R3 INSR DGKZ LEP LEPR IRS1 Leptin signaling pathway WP2034 PDE3B PTPN11 RPS6KB1 CREB1 SOCS3 RPS6KA1 RPS6 KHDRBS1 CCND1 JAK1 JAK2 IL1RN BCL2L1 IL1B PLCG1 NCOA1 SP1 CDC42 PLCG2 LEP LEPR FOXO1 EIF4EBP1 NOS3 EIF4E MAPK1 ROCK2 MAPK3 CISH CFL2 CHUK MTOR KPNA4 AKT1 SRC PTK2 NFKB1 PRKAA1 STAT1 PRKAA2 SOS1 STAT3 ESR1 HRAS ROCK1 BAD GRB2 MAPK14 ELK1 MAPK8 RAC1 ACACA ACACB PIK3R1 PIK3R2 PTPN1 SHC1 RELA RAF1 IKBKB ERBB2 BAX PTEN GSK3B GSK3A RHOA FYN SH2B1 SOCS2 STAT5B IKBKG SOCS7 IRS1 REL MAP2K1 MAP2K2 let-7 inhibition of ES cell reprogramming WP3299 POU5F1 KLF4 TRIM71 MYC SOX2 EGR1 Linoleic acid metabolism known to be affected by coronavirus infection WP4853 ACOT2 FADS2 FADS1 ELOVL2 ELOVL5 Lipid Metabolism Pathway WP3965 ACLY PRKAA1 PRKAA2 PRKAB1 PRKAB2 HILPDA FASN PDHA1 ACSBG1 BCKDHA PNPLA2 ACSS2 PRKAR2B PRKAG2 ACACA PRKAG1 PRKAR1A LIPE PRKAR1B PRKAR2A PRKAG3 ABHD5 AKT3 PLIN1 PRKACA AKT1 PRKACB AKT2 PRKACG Liver X receptor pathway WP2874 ABCG8 ABCG5 CYP2B6 NR1H3 RXRA CYP3A4 SREBF1 CYP7A1 SCD FASN LncRNA involvement in canonical Wnt signaling and colorectal cancer WP4258 CSNK2B CSNK1A1L NKD2 DVL1 CSNK2A2 CCND1 DKK4 CSNK2A1 KREMEN1 MYC CSNK1E EZH2 CSNK1A1 DKK2 DVL3 DVL2 SOX17 MAP3K7 WIF1 PORCN WNT4 CER1 NKD1 FRAT1 SOST AXIN1 AXIN2 WNT16 TCF3 CCND2 CCND3 CSNK2A3 FZD3 FZD5 H2AFY2 NLK FZD1 WNT3 WNT2 WNT6 WNT5A SERPINF1 FZD8 WNT7B WNT7A FZD9 FZD6 SFRP2 FZD7 SFRP1 WNT1 CTBP2 ROR1 CTBP1 RYK FZD10 TCF7 PLAU TCF7L2 TPTEP2-CSNK1E CXXC4 CDK6 WNT10B FRAT2 WNT2B NOTUM WNT11 TCF7L1 CTNNB1 WNT10A APC2 SFRP5 SFRP4 ROR2 RUVBL1 FOSL1 APC LEF1 CDK8 JUN CHD8 SENP2 TFAP2A CTNNBIP1 LRP6 DKK1 HNRNPU WNT3A LRP5 HNRNPK GSK3B WNT5B FZD2 ATF3 LncRNA-mediated mechanisms of therapeutic resistance WP3672 WNT6 HIF1A ABCB1 BCL2L1 CDKN1A TP53 LTF danger signal response pathway WP4478 TLR4 CD14 TRAF6 NFKB1 MAPK1 TNF LTF IL1A TLR2 IFNA1 TREM1 AGER IL6 IFNB1 CXCL8 IRAK4 IL1B IRAK1 MYD88 Lung fibrosis WP3624 CCL4 HGF SFTPA1 CCL5 SERPINA1 TNF CCL11 TGFB1 SMAD7 HMOX1 CYSLTR2 CMA1 CALCA IGF1 IL1B CCL3 CCL2 MECP2 PDGFA NFE2L2 SFTPC TERT PDGFB CCR2 SFTPA2 MUC5B PARN IL6 ATP11A IL5 IL4 EDN1 FAM13A SPP1 DPP9 SKIL CSF3 FGF7 STN1 CSF2 DSP CXCL2 ELN FGF2 EGF FGF1 CXCL8 BMP7 CCR3 MT2A TIMP1 TGFA IL13 IL12B CEBPB CTGF PTX3 ELMOD2 RTEL1 GREM1 MMP2 PLAU MMP9 Macrophage markers WP4146 CD14 CD163 RAC2 CD74 CD86 LYZ CD83 CD68 F3 Major receptors targeted by epinephrine and norepinephrine WP4589 ADRA2A ADRA2C ADRB1 ADRB2 ADCY5 ADCY6 ADRA1D ADCY7 ADCY8 ADCY9 ADCY1 ADCY2 ADCY3 ADCY10 ADCY4 Male infertility WP4673 HORMAD2 UBE2B USP8 LTF REC8 EPSTI1 HLA-DRA EP300 AHR SHMT1 ATM MLH1 BCL2 YBX2 FAS UBD FASLG BHMT RAG1 NOS1 DDX4 DAZL NOS2 DAZ1 NOS3 PMS2 VCX THBS1 RGS9 PRMT6 SLC16A7 CLU CHD2 EPPIN AR TSSK6 CYP17A1 SIRPA POLB ARNTL INSR CCNK POLG H2BFWT SLC46A1 PON1 CRISP2 TEX15 UBR2 MDM2 TSSK4 SEPT12 KLK2 MAS1L SOD3 SOD2 SEMG1 DND1 OR2W3 SOX5 PIWIL3 ERCC1 ESR2 AHRR PARP1 DDX20 DAZ4 MSMB PON2 CYP26B1 PEMT TAS2R38 XPC SPATA17 STRA8 RFC1 TNF XRCC5 PRM2 HIST3H3 PUM2 PIWIL2 PRM1 BRCA2 FOLH1 HMGA1 BRDT ERCC2 MTHFD1 XRCC2 MTHFR XRCC4 XRCC3 AGO2 PRDM9 TCN2 HORMAD1 NFE2L2 PACRG PIWIL1 NANOS1 PEX10 ETV5 GPX1 CYP1A1 CDK9 CREBBP CAT KDM3A SRD5A2 CDC42BPA SPO11 ABCB1 HIST1H4A MTRR LIG4 ESR1 PSAT1 CCDC36 CTCFL MOV10L1 PIWIL4 TMEM132E PRM3 SIRPG APOB TRIP13 CCNA1 MTR CLOCK CXXC1 FOLH1B DAZ3 DAZ2 LRWD1 USP26 MLH3 GNAO1 ABLIM1 MMP2 NQO1 MSH4 CCNT1 MSH5 CCNT2 MMP9 Mammalian disorder of sexual development WP4842 PBX1 INSL3 FGF9 RBFOX2 CTNNB1 RSPO1 GATA4 SOX9 PTGDS FGFR2 WNT4 WT1 EMX2 AMH AMHR2 CBX2 DMRT1 FOXL2 SOX8 MAPK11 SRD5A1 SRY FST DHH NR5A1 Mammary gland development pathway - Embryonic development (Stage 1 of 4) WP2813 TERT TNF SFRP1 ERBB4 TGFB1 CCND1 MYC NRG3 ALPL CLDN4 AKT1 CDH1 ITGA6 ITGB1 ZEB2 Mammary gland development pathway - Involution (Stage 4 of 4) WP2815 CHI3L1 MYC TP53 STAT3 CDH1 IL6ST SOCS3 E2F1 MMP9 BAX Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4) WP2817 PNCK PGR TNFRSF11A TTC9 ESR1 GAL PRLR CCND1 JAK2 MYC BCL2L1 NR3C1 ATP2C2 CAV1 GJB2 EGFR PRL EIF4E PTPN1 TNFSF11 ELF5 ESR2 ERBB4 TPM3 ERBB3 ERBB2 USF2 CEBPB CEBPA CSN2 CHUK YY1 Mammary gland development pathway - Puberty (Stage 2 of 4) WP2814 TIMP1 PGR VIM NRIP1 ESR1 FOSL1 ERBB2 AREG CCND1 MYC EGF FN1 STAT5A MAP3K1 role in promoting and blocking gonadal determination WP4872 MAPK1 SOX9 AXIN1 FGF9 FGFR2 WNT4 ROCK1 GSK3B RHOA GADD45G CTNNB1 FOXL2 MAP3K1 MAPK11 MAP3K4 FRAT1 SRY MAPK and NFkB signaling pathways inhibited by Yersinia YopJ WP3849 MAP2K6 TRAF6 NFKB1 MAPK1 NFKBIA CHUK RAF1 RRAS MAP3K1 IKBKB IKBKG MAP3K14 MAPK Cascade WP422 SIPA1 MAP2 MBP NRAS SOS1 MAP3K12 HRAS BRAF GRB2 MAPK14 ELK1 LAMTOR3 MAPK1 MAPK12 PLCB3 MAPK3 RAF1 RASA3 MAP2K6 MAP2K7 MAP3K2 ARAF MAP3K1 RRAS SOS2 MAP3K3 MAP2K4 MAPK10 MAP2K1 KRAS MAP2K2 JUN MAP2K3 MAPK pathway in congenital thyroid cancer WP4928 MAPK3 SHC1 RAF1 SOS1 FOS GAREM2 BRAF MYC ELK1 ALK SOS2 KSR1 MAP2K1 MAP2K2 KRAS JUN MAPK Signaling Pathway WP382 MAP3K11 MAP4K1 MAP3K6 MYC FAS FASLG MAPK8IP3 LAMTOR3 PDGFA PDGFB FLNB FLNA ARAF RRAS CACNG5 MAP3K20 CACNG4 FLNC CD14 MAPKAPK5 PDGFRB RELA RELB PAK1 IL1A HSPA6 IKBKB MAP2K5 MAP2K6 HSPA2 MAP2K7 HSPA1L HSPA1B PLA2G4B HSPA1A MAPK11 MAPK9 MAPK10 MAPK13 MAP2K1 MAP2K2 MAP2K3 TNF NFATC1 NRAS FOS CACNG8 CACNG6 CACNG7 PAK2 HSPB1 RASGRP3 IL1R1 HSPA8 IL1B NF1 MKNK1 CASP3 TNFRSF1A MAP4K2 TAOK1 MAP3K2 CHUK LRRK2 ATF2 NFATC3 NFKB1 RAC2 NFKB2 RAC3 MAP4K4 FGF9 FGF8 FGF7 FGF6 FGF5 FGF4 FGF3 ELK4 EGF FGF2 CRKL FGF1 CRK ELK1 SRF MRAS TAOK3 RAC1 EGFR FGF21 PPP3CA TP53 RAF1 PPP3CB FGFR4 FGFR2 FGFR3 FGFR1 RAPGEF2 RASGRP4 TAB2 DUSP2 DUSP1 FGF14 FGF13 FGF12 FGF11 FGF10 CACNA1H CACNA1G BDNF DUSP7 CACNA1I DUSP6 DUSP4 DUSP3 RPS6KA3 TAOK2 TGFB3 TGFBR1 TGFBR2 FGF22 TGFB1 PPP5D1 TGFB2 MAP4K3 DUSP9 CDC25B DUSP8 PPP3CC DUSP10 CDC42 PPP3R1 PPP3R2 PPP5C PTPN7 DAXX MEF2C RRAS2 IL1R2 MAP3K7 MAPK8IP1 STMN1 GNG12 PLA2G4F MAP3K1 MAP3K4 ARRB1 MAP3K5 FGF18 ARRB2 FGF20 TRAF2 TRAF6 PLA2G4A SOS1 HRAS MAPK8IP2 PTPN5 PLA2G4D CACNA1A CACNA1B NTF3 CACNA1C NTF4 CACNA1D CACNA1E CACNA1F CACNA1S FGF17 FGF16 RASGRP2 NLK CACNA2D2 MAPK12 RPS6KA5 NTRK1 CACNA2D1 NTRK2 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 AKT3 PRKACA SOS2 PRKACB MAP2K4 PRKACG MAPKAPK3 RASGRP1 DDIT3 CACNG2 GADD45A CACNG3 PRKCD PRKCG NR4A1 MAPKAPK2 MAP3K14 BRAF STK3 PRKCA PLA2G4C STK4 TAB1 NGF MAPK1 MAPK3 RPS6KA4 MAPK7 CACNA2D4 DUSP16 JUND RAP1A ECSIT RAP1B MKNK2 MAPT AKT1 AKT2 KRAS JUN FGF19 MAP3K12 FGF23 GNA12 GRB2 MAPK14 MAPK8 MAX PPM1A PPM1B MAP3K13 PLA2G4E MAP3K8 CACNA2D3 ATF4 IKBKG RASA1 PTPRR RASA2 RASGRF1 RASGRF2 Matrix Metalloproteinases WP129 TNF MMP23B MMP14 TCF20 MMP15 MMP16 MMP24 MMP17 MMP19 TIMP2 TIMP1 TIMP4 MMP25 TIMP3 MMP27 MMP11 MMP12 MMP20 MMP13 MMP21 BSG MMP28 MMP26 MMP1 MMP2 MMP3 MMP7 MMP8 MMP9 MMP10 mBDNF and proBDNF regulation of GABA neurotransmission WP4829 STAT3 CREB1 ROCK1 SLC12A5 NGFR JAK2 GABRP GABRG3 GABRG2 GABRG1 GABRE GABRD PLCG1 PIK3R3 PIK3CG PIK3R1 PIK3R2 SHC1 GABRB3 GABRB2 GABRB1 AP2A1 PIK3CA AP2A2 PIK3CB CREM AP2B1 PTEN GABRA6 NTRK2 GABRA5 RHOA GABRA4 GABRA3 GABRA2 GABRA1 GABRQ BDNF Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms WP4534 PAK3 TEAD4 MAP4K1 MAP4K5 TEAD1 NF2 MAP4K4 LIMD1 TEAD3 PAK5 MAP4K3 PAK2 YY1AP1 CTNNB1 STK3 MAPK8 ITGB8 ACTC1 CDH1 ACTG1 PAK4 ACTG2 TAZ YWHAQ LATS1 ITGB3 ACTA1 TEAD2 ITGB4 ACTA2 ITGB5 MAP4K2 MST1 PAK1 ITGB6 ITGB7 CTNNA1 SGMS1 SAV1 ACTB MAPK9 MAPK10 ITGB1 ITGB2 BUB1B-PAK6 SRC PAK6 MECP2 and Associated Rett Syndrome WP3584 SP3 TAF1 MAG SST CREB1 DHX9 TET3 GAMT GPRIN1 TET2 SIN3A IGF2 IGF1R RPS6 IGF1 EZH2 SP1 NF1 POU4F1 MECP2 REST MEF2C GRIN1 RBFOX1 NREP MYT1 ARHGEF26 CNP CSRP1 PRPF38A MTOR TET1 AKT1 BCL6 DLX5 CTCF E2F1 TAP1 FOXG1 MBP SMC3 MPP1 GRIA3 GAD1 HNRNPH1 GRIA1 HDAC1 GABRR2 HNRNPF FGF5 YBX1 FGF4 FGF3 FGF2 FUS DLX6 FKBP5 UBE3A SGK1 PSIP1 OPRK1 CAMK2A CDON POU3F2 NCOR1 CEBPD TARDBP PTEN GRID1 FUT8 GRIA4 BDNF MED and Pseudoachondroplasia genes WP4789 COMP COL9A3 MATN1 COL9A2 COL9A1 MATN3 Melanoma WP4685 NRAS FOS CREB1 CDK6 CDK4 CCND1 PREX2 BRAF NF1 CDH1 LAMTOR3 GRIN2A SHC2 MAPK1 CALML5 MAPK3 CDKN2A CDKN1A ETS1 ARAF AKT1 CALM1 AKT2 CALM2 E2F1 KRAS GRM3 STK19 GADD45B CALM3 SOS1 HRAS MDM2 BAD KIT GADD45G GRB2 BAK1 E2F3 ELK1 CALML3 E2F2 VCL PIK3R3 RAC1 POLK CALML4 PIK3R1 PIK3R2 KDR MITF TP53 PAK1 RAF1 CALML6 ERBB4 PIK3CA PIK3CB BAX PIK3CD PTEN DDB2 AKT3 SOS2 MAP2K1 MAP2K2 GADD45A RB1 Melatonin metabolism and effects WP3298 TRAF6 NFKB1 PER1 MAP2 TPTEP2-CSNK1E ADRB1 CYP2C19 CSNK1E CSNK1D MTNR1A MTNR1B PRKCA ASMT IRAK1 MAOA CAMK2A FOXO1 CLOCK PER2 AANAT PER3 SIRT1 SULT1A1 GSK3B CYP1B1 CYP1A2 CYP2D6 CYP1A1 APOE EDN1 CALM1 ARNTL CRY2 CALM2 CRY1 ACHE ECE1 Mesodermal commitment pathway WP2857 LEFTY2 MEIS1 TRIM71 HMGA2 CCND1 ZIC5 FOXC2 AHDC1 ZFHX4 UBR5 SESN1 ACVR1 SLC2A12 ACVR2A ACVR2B CHRD FOXH1 YAP1 LATS1 CEP250 RGS10 SOX17 ATP8B2 DDAH1 HPRT1 C9orf72 WDFY2 CSRP2 ARID5B NANOG TBX6 TRIM5 EMSY PITX2 BHLHE40 TOX PIAS1 AXIN1 AXIN2 FOXC1 NOG CCDC6 NABP2 NCAPG2 LEFTY1 BMP4 WDCP BMP7 BMPR1A FZD5 SOX21 BMPR2 KIAA0754 NLK WDHD1 AEBP2 TBX3 ACACA TCF4 WNT3 FZD4 SMAD1 EOMES SMAD2 SMAD3 PRKAR1A FZD8 SMAD4 AMH CTBP2 PARP8 PRKACA TBX1 MIXL1 SOX2 ARL4A PHF6 C1QBP HAND1 POU5F1 ZNF281 TEAD1 TOX3 SMAD6 CUL4B PLCH1 GATA3 JAK2 TCF7L1 EPB41L5 GRHL2 VAV3 MBTD1 GATA6 ASCC3 ADAM19 FOXA2 TRERF1 TEAD2 NFE2L2 BCORL1 RPL38 KLF4 MACF1 HNF4A DNMT3B LEF1 CRTC1 KLF5 FOXA1 TET1 KDM6A JARID2 SETD2 C6orf201 PBX1 DLL1 ELP4 EXT2 FGF8 EXT1 PAX6 TWSG1 HTT RARB DIP2A RARG ELK4 ZNF462 HES7 CCDC88A SRF TRIM28 PPP2CA MSGN1 DKK1 WNT3A MTF2 GDF3 PBX3 FGFR1 SCHIP1 NODAL INHBA ZIC3 ZIC2 SNAI1 MET in type 1 papillary renal cell carcinoma WP4205 HGF PAK3 PTPN11 NRAS INSL3 C8orf34 PAK5 PAK2 BRAF JAK3 ALK PLCG1 CDC42 PAK4 GAB1 MAPK1 MAPK3 RAP1A RAP1B CDKN1A ARAF ETS1 AKT1 AKT2 PRCC PTK2 SRC KRAS JUN RPL11 MET SOS1 STAT3 HRAS RAPGEF1 BAD GRB2 CRKL CRK MAPK8 PIK3R3 STRN ELOA RAC1 PIK3R1 PIK3R2 RAF1 PAK1 PIK3CA PIK3CB PIK3CD TFE3 AKT3 CBL SOS2 BUB1B-PAK6 MAP2K1 PAK6 MAP2K2 Metabolic pathway of LDL, HDL and TG, including diseases WP4522 LIPG LPL LIPC ABCA1 LDLRAP1 CETP LDLR ANXA2 APOA1 APOA2 APOE APOB LCAT MTTP PCSK9 SCARB1 Metabolic reprogramming in colon cancer WP4290 PDHB SHMT2 RPIA SLC16A3 ACLY PGAM1 SLC1A5 HK3 PYCR2 FH MDH2 SDHB FASN PDHA1 TKT PSAT1 GLUD1 GLS GPI LDHA TIGAR PYCR1 PKM GOT2 ACO2 SUCLG2 TALDO1 IDH3A IDH2 PPAT PGK1 PFKL ENO1 DLST PAICS GAPDH SLC2A1 ALDOB PGD PSPH GART G6PD Metabolism of alpha-linolenic acid WP4586 ALOX15 FADS2 FADS1 ALOX12 PTGS2 ALOX5 Metabolism of Spingolipids in ER and Golgi apparatus WP4142 SGMS2 CERK SGPP2 UGT8 UGCG B4GALT1 B4GALNT1 CERS3 GALNT16 SGPP1 GALNT1 ST6GALNAC3 KDSR SGPL1 B4GALT2 SPHK1 B3GALT2 B3GALT1 SPHK2 B3GALNT1 Metapathway biotransformation Phase I and II WP702 CYP4F3 NDST3 CHST1 CHST3 INMT CYP11A1 HS3ST6 CYP8B1 CHST5 CYP7A1 CYP4B1 HS6ST2 HS3ST5 AKR1B1 NAT9 GSTM1 NAT14 GSTA4 SULT1C3 CYP3A5 CYP3A4 GSTA3 CYP2S1 CYP2J2 NAA20 GSTM5 GSTM4 CYP2R1 GSTM3 GSTM2 CYP4F2 NAT2 CYP4V2 GAL3ST1 GLYATL1 CYP27B1 CYP27A1 CYP26A1 CYP24A1 TPMT KCNAB3 GSTZ1 GSTT2 CYP21A2 CYP19A1 NAA80 CYP17A1 GSTP1 CYP11B2 CYP11B1 CHST7 GSTCD AKR1C4 UGT2A1 AKR7A3 CHST10 CYP4F8 NDST4 FMO5 CYP27C1 EPHX2 EPHX1 UGT2B28 FMO3 FMO2 CYP20A1 FMO1 UGT2A3 SULT1A4 NAT10 CHST12 CYP51A1 CYP39A1 UGT1A3 UGT1A1 UGT1A4 FMO4 CYP4F12 HS2ST1 HS6ST3 SULT1E1 AKR1C2 GLYAT AKR1C1 SULT1A1 SULT1C2 SULT1C4 AKR1B10 CYP26B1 NAA40 AKR7A2 UGT2B4 CYP4X1 CYP2U1 UGT2B7 KCNAB1 CYP7B1 UGT2B17 UGT2B15 SULT6B1 NAT8 CYP4F22 GAL3ST4 NAT8L SULT1B1 CYP46A1 CHST14 SULT2B1 SULT2A1 CHST11 HS3ST3B1 HS3ST4 GLYATL2 CHST2 LOC105369243 GPX5 HNMT SULT4A1 GSTA5 CHST9 HS6ST1 CHST13 GPX3 NAA30 GPX2 AKR1D1 CYP1B1 CYP4F11 CYP1A2 UGT1A9 CYP1A1 SULT1A2 MGST1 GSTO2 MGST2 MGST3 CYP2A7 CYP2A6 GPX4 GAL3ST3 CHST8 GSTK1 GSTO1 NAA50 NDST1 GSTT2B BAAT CYP3A43 CYP2C8 CYP2C19 CYP2B6 UGT1A6 COMT UGT1A7 CYP2A13 UGT1A10 UGT2A2 CYP3A7 HS3ST1 GAL3ST2 HS3ST3A1 UGT1A5 HS3ST2 NDST2 CYP26C1 CYP2C9 AKR1C3 CHST6 CYP2F1 CYP2E1 AKR1A1 NNMT CYP2D6 CYP2C18 CHST4 KCNAB2 GSTA2 GSTA1 CYP2W1 GSS GSR CYP4Z1 UGT2B11 Metastatic brain tumor WP2249 CDK6 MYC E2F3 CDC42 PIK3R1 TP53 Methionine De Novo and Salvage Pathway WP3580 MSRB2 MSRA MAT1A MAT2A AHCY TXN AMD1 MTAP APIP ADI1 IL4I1 MAT2B ENOPH1 BHMT MSRB3 TAT SMS MRI1 CHDH ODC1 SRM MTR Methionine metabolism leading to sulfur amino acids and related disorders WP4292 ADK MAT1A CDO1 CBS GNMT MAT2B BHMT AHCY CTH MTR CSAD Methylation Pathways WP704 PNMT NNMT MAT1A COMT MAT2A MAT2B INMT HNMT TPMT Mevalonate arm of cholesterol biosynthesis pathway WP4190 GGPS1 ACAT1 FDPS IDI1 HMGCS1 MVD MVK HMGCR HMGCL IDI2 PMVK Mevalonate pathway WP3963 FDPS ACAT2 MVD HMGCS1 MVK HMGCR PMVK MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement WP4560 ITGB3 MAPK1 MAPK3 CREB1 TJP1 MFAP5 PXN ITPR1 ITGAV LPP PLCG1 PRKCQ VCL MYL2 PTK2 JUN MYLK ACTN1 MFAP5-mediated ovarian cancer cell motility and invasiveness WP3301 RYR3 TNNC1 ITGB3 MAPK1 MAPK3 CREB1 MFAP5 PLCG1 PRKCQ ITGAV ITPR3 PTK2 JUN Microglia Pathogen Phagocytosis Pathway WP3937 RAC2 PIK3C2A SYK RAC3 ARPC1B PIK3C3 ITGAM FCER1G CYBB TREM1 CYBA PIK3R6 C1QA VAV3 PLCG2 C1QB PTPN6 NCF2 C1QC PIK3R3 NCF4 LAT RAC1 FCGR1A NCKAP1L PIK3CG PIK3R1 PIK3R2 LYN VAV2 HCK PIK3CA PIK3CB PIK3CD NCF1 SIGLEC7 TYROBP ITGB2 TREM2 VAV1 MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma WP3593 HES1 HIF1AN HIF1A VEGFA VEGFC HEY1 VEGFB MicroRNAs in cardiomyocyte hypertrophy WP1544 EIF2B5 TGFB1 IGF1R NRG1 DVL1 IGF1 MYLK3 HDAC5 ROCK2 CALM1 EDN1 CALM2 IKBKE PLA2G2A STAT3 ROCK1 HDAC4 CAMK2D PIK3CG FZD1 PIK3R1 PIK3R2 PLCB2 WNT5A IKBKB PIK3CA PDPK1 PIK3CB PIK3CD MAP2K5 MAP2K6 MAP2K7 RHOA CTF1 MAP2K4 NPPA MAP2K1 MAP2K2 NPPB MYLK MAP2K3 TNF CDK7 MAP3K14 CTNNB1 HDAC7 PRKCB TAB1 GATA4 PRKG1 MAPK1 MAPK3 MAPK4 MAPK7 CISH IL6ST CHUK CDK9 MTOR AKT1 NFATC4 AKT2 RCAN1 MYEF2 NFKB1 EGF FGF2 MAPK14 MAPK8 PIK3R3 LIF RAC1 LRP6 WNT3A LRP5 HDAC9 PPP3CA RAF1 PPP3CB FGFR2 AGT GSK3B FZD2 IKBKG mir-124 predicted interactions with cell cycle and differentiation WP3595 CTDSP1 SIX4 PRKAA1 STK11 STRADB PTBP1 miR-509-3p alteration of YAP1/ECM axis WP3967 BCAR1 GPC6 TEAD2 TEAD4 THBS2 TEAD1 EDNRA TEAD3 PBX3 TWIST1 COL3A1 SNAI2 FN1 COL5A1 COL1A1 SPARC YAP1 miR-517 relationship with ARCN1 and USP1 WP3596 USP1 CDKN1A ID2 ID1 ARCN1 miRNA Biogenesis WP2338 DICER1 XPO5 DROSHA DGCR8 TARBP2 RAN miRNA regulation of DNA damage response WP1530 MCM7 RFC1 CREB1 CDK6 CDK5 ATM CDK4 CCND1 BRCA1 CDK2 FAS CCNB3 MYC CDC25A ATRIP CDC25C PIDD1 SESN1 APAF1 BID RAD1 CASP3 PRKDC HUS1B CDC20B TLK1 CDKN1B CDKN1A RRM2B CASP8 CASP9 RPA2 CYCS E2F1 GADD45B TNFRSF10B ABL1 PMAIP1 RAD9A RAD17 FANCD2 MDM2 CCNB1 GADD45G CCND2 CCND3 CHEK1 CCNE1 H2AFX CHEK2 RAD50 PML CCNB2 MRE11 CCNE2 SMC1A TP53AIP1 RAD52 NBN TP53 BAX SFN DDB2 BBC3 CDK1 ATR TLK2 CCNG1 RAD51 RB1 GADD45A miRNA regulation of p53 pathway in prostate cancer WP3982 TNFRSF10B PMAIP1 SIAH1 ATM MDM2 SESN3 SHISA5 APAF1 BID CHEK2 EI24 CASP3 ZMAT3 PERP SERPINE1 TP53AIP1 TP53 BAX PTEN DDB2 BBC3 CASP8 CYS1 CASP9 miRNA regulation of prostate cancer signaling pathways WP3981 CCND1 BCL2 KLK3 CTNNB1 FOXO1 PDGFA MAPK1 CREB3L1 CDKN1B AR CDKN1A CREBBP CASP9 MTOR KRAS NFKB1 NFKBIA SOS1 PLCL2 MDM2 BAD NFATC2IP GRB2 PDGFRB TP53 RAF1 PIK3CA GSK3B AKT3 IKBKG TCF7 MAP2K1 MAP2K2 miRNA targets in ECM and membrane receptors WP2911 COL5A3 TNXB COL4A2 COL4A1 COL3A1 LAMB2 LAMC1 COL1A2 LAMA4 SDC2 ITGA11 THBS1 THBS2 ITGB5 ITGB6 ITGA1 COL6A3 COL6A2 COL6A1 COL5A2 FN1 COL5A1 miRNAs involved in DNA damage response WP1545 CREB1 CDK6 ATM CCND1 MYC CDC25A CDKN1B CDKN1A E2F1 ABL1 CCND3 CCNE1 H2AFX TP53 RAD52 miRNAs involvement in the immune response in sepsis WP4329 CCL4 TNF GZMB TLR7 CCL3 TAB1 TLR4 MAP3K7 VCAM1 IL6 CHUK IRAK4 MYD88 TRAF3 TRAF6 NFKB1 NFKB2 NFKBIA ICAM1 MAPK14 CXCL8 ELANE MAPK8 IRAK1 IRF1 LCN2 RELA RELB IL1A IKBKB TAB2 TLR8 IL10 IRF5 IKBKG IRF7 REL Mitochondrial CII Assembly WP4920 SDHA SDHAF4 SDHAF3 SDHAF2 SDHC SDHB SDHAF1 SDHD Mitochondrial CIV Assembly WP4922 COX6B1 COX20 COA3 COX6A1 COX14 COX16 PET117 COX15 COX11 TACO1 COX19 COX5A SCO2 COX18 COX17 HIGD1A COX10 COX8A COX7C PNKD COX7B COX4I1 COX7A2 COX6C COA6 TMEM177 SMIM20 NDUFA4 SURF1 COX1 PET100 COX2 CMC1 COX3 COX5B Mitochondrial complex I assembly model OXPHOS system WP4324 NDUFA1 NDUFA2 NDUFA3 ACAD9 NDUFV2 NDUFA12 NDUFS2 NDUFS3 NDUFV1 NDUFS4 NDUFS5 NDUFS6 DMAC1 NDUFAF3 ND5 ND6 NDUFAF4 FOXRED1 ECSIT NDUFA5 NDUFV3 ND1 ND2 ND4 NDUFAF6 TMEM70 ND4L NDUFA10 NDUFAB1 DMAC2 NDUFB1 NDUFB2 NDUFB3 COA1 TMEM186 TIMMDC1 TMEM126B NUBPL NDUFAF1 NDUFA6 NDUFA7 NDUFA8 NDUFB11 NDUFAF2 NDUFAF7 NDUFB10 NDUFC1 NDUFC2 NDUFS1 NDUFA13 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 Mitochondrial complex III assembly WP4921 UQCRC2 UQCRC1 UQCRFS1 UQCRH UQCRB UQCC1 UQCR11 CYTB UQCRQ UQCR10 LYRM7 UQCC2 BCS1L UQCC3 CYC1 TTC19 Mitochondrial fatty acid synthesis pathway WP4317 HSD17B12 OXSM MECR MCAT ACACA Mitochondrial Gene Expression WP391 PPARGC1B MYEF2 POLRMT PPP3CA TFB2M GABPA CREB1 HCFC1 PPRC1 MTERF3 GABPB1 ESRRA TFAM SP1 PPARGC1A TFB1M MTERF1 CAMK4 NRF1 Mitochondrial LC-Fatty Acid Beta-Oxidation WP368 ACSL1 ACADL ACADM SCP2 ACADS ACADVL CPT1A HADH HADHA ACSL4 ACSL3 ACSF2 EHHADH ECI1 CPT2 SLC25A20 PECR Modulators of TCR signaling and T cell activation WP5072 SOCS1 MAP4K1 SMARCB1 MAP3K14 SH2B3 RHOH ZFP36L1 PLCG1 RNF7 PTPN6 UBASH3A DGKZ MALT1 CD3D LAT CD3E CD3G MEF2D CD247 FIBP SH2D1A AGO1 CUL5 ARIH2 CDKN1B CHUK CARD11 CD5 PRKCQ AKT1 TNFAIP3 CD8A VAV1 NFKB1 TRAF6 NFKBIA GRAP2 RPRD1B LCP2 GRB2 ZAP70 GNA13 LCK ELOB TMEM222 PIK3R1 PIK3R2 RELA IKBKB PDPK1 PCBP2 NDUFB10 MAP3K8 CD28 IKBKG CBLB REL RASA2 DGKA ITK BCL10 Molybdenum cofactor (Moco) biosynthesis WP4507 MARC2 XDH SUOX AOX1 GPHN MOCS1 MOCS2 Monoamine GPCRs WP58 HTR7 HTR6 ADRA2A HTR5A HTR4 ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 HTR2C HTR2B HTR2A CHRM5 HTR1F DRD5 DRD4 DRD3 DRD2 DRD1 HTR1E CHRM4 CHRM3 HTR1D HRH2 HTR1B HTR1A CHRM2 CHRM1 ADRA1D ADRA1B HRH1 ADRA1A Monoamine Transport WP727 FBXO32 SLC6A3 TNF SLC6A2 SLC6A4 AMPH TGFB1I1 NECTIN2 ADORA2A CDC25C MAPK14 TPH2 IL1R1 IL1B NOS1 UNC13B RBL2 PPP2CB STX1A SLC6A1 TH ITGB3 TNFRSF11B AGT DBH SCAMP2 TSC2 SYN1 TDO2 SLC5A7 HRH3 ACHE mRNA Processing WP411 RBM39 EFTUD2 NCBP2 SNRPD1 SRRM1 PTBP2 PHF5A CPSF4 CELF2 CDC40 CELF1 CSTF2T NCBP1 NONO SRSF10 SNRNP70 SPOP SNRPA1 SNRPA SNRPB2 SNRPB XRN2 POLR2A SF3B4 CLK3 CLK2 PRPF6 CLK1 SF3A3 SF3B3 SF3B1 SNRPD3 SNRPD2 PRPF4B SNRPF SNRPE SNRPN SUGP2 CD2BP2 SNRPG PSKH1 PRPF4 PRPF3 TXNL4A YBX1 CSTF3 SREK1 CSTF2 PAPOLA CSTF1 PRPF8 SF3B2 HNRNPR SNRNP40 SRSF9 SFPQ NUDT21 NXF1 PRMT1 PRMT2 DDX20 RNPS1 U2AF2 CPSF1 LSM2 PRPF18 PTBP1 DICER1 DHX38 SF3A1 SRSF5 RNGTT SRSF7 SRSF6 TRA2B SFSWAP RNMT DHX9 SF3A2 SUPT5H CELF4 CLP1 DDX1 SNU13 U2AF1L5 CPSF2 SRSF2 DHX16 SRSF1 METTL3 TMED10 SRSF4 SRSF3 DHX8 RBM5 PABPN1 HNRNPA1 CLK4 LSM7 CPSF3 DHX15 SUGP1 RBM17 HNRNPA2B1 HNRNPM HNRNPH2 HNRNPH1 HNRNPD HNRNPC HNRNPAB SRP54 CLASRP PRPF40A FUS HNRNPU HNRNPL HNRNPK SMC1A DNAJC8 PPM1G RBMX PCBP2 SF3B5 SRPK2 SRPK1 U2AF1 MTHFR deficiency WP4288 COMT CHPT1 BHMT EHMT1 ASMT GRIN2D MTHFR CASP3 CHDH GRIN2A GRIN1 CHKA PCYT1A MARS HNMT EHMT2 NDUFAF7 SGMS1 DNMT3B DNMT3A DNMT1 CASP9 ALDH7A1 CYCS PEMT Myometrial relaxation and contraction pathways WP289 OXT OXTR PDE4B PDE4D GABPA IGFBP3 RGS5 IGFBP2 GNGT1 GNG11 IGFBP1 ADCY5 GNG7 ADCY6 ADCY7 GNG5 ADCY8 GNG4 GNG3 ADCY9 GNB3 GNB2 GNG13 NOS1 DGKZ NOS3 RGS10 GNG8 RGS7 RGS9 RGS11 RGS16 GNG12 ATP2A2 IGFBP6 ATP2A3 IGFBP5 GABPB1 IGFBP4 MYLK2 CALD1 RGS6 CALM1 RAMP2 RAMP3 ARRB1 RAMP1 ARRB2 LPAR1 CALM2 CALM3 RLN1 ADM ACKR3 RGS14 CAMK2A CAMK2B LINC02210-CRHR1 CAMK2D CAMK2G RYR3 PKIB RYR2 PRKAR1A PLCB3 RGS20 PRKAR1B PLCD1 PRKAR2A GUCA2A RYR1 CACNB3 ITPR1 GJA1 ITPR2 PRKACA PRKACB MYL2 PKIA MYL4 CREB3 PRKCD PRKCE PRKCG PRKCH PKIG PRKD1 FOS GRK6 CNN1 CREB1 MAFF CALCA GUCY1A1 IL1B GUCA2B PRKAR2B SP1 SLC8A1 PLCG1 PRKCA PLCG2 PRKCB ITPR3 YWHAQ GRK5 CORIN GRK4 ACTA1 ACTA2 YWHAG YWHAE YWHAZ YWHAH RXFP2 CRHR1 RGS18 CRH PRKCZ CRCP IL6 GPR182 ATF6B ETS2 CNN2 ATF2 PRKCQ ACTB YWHAB JUN ADCY4 NFKB1 GSTO1 GNG2 GNB4 RGS17 RGS1 ATF5 ACTC1 RGS2 ACTG1 RGS3 RGS4 GNB1 RXFP1 GNAS SFN GNAQ ATF1 ATF3 ATF4 ADCY1 ADCY2 GNB5 ADCY3 RGS19 NAD Biosynthesis II (from tryptophan) WP2485 AFMID KMO KYNU QPRT HAAO NADSYN1 TDO2 NMNAT1 NAD Metabolism in Oncogene-Induced Senescence and Mitochondrial Dysfunction-Associated Senescence WP5046 SIRT2 SIRT5 SCO2 PRKAA1 RELA TP53 NMNAT2 SIRT3 SIRT1 MDH1 MDH2 PARP1 IL6 ELAVL1 HMGA1 IL1B SLC2A1 GOT2 SLC2A4 GOT1 CCL27 NAMPT G6PD RB1 NAD metabolism, sirtuins and aging WP3630 ROS1 NFKB1 HIF1A TFAM PPARG SIRT3 SIRT1 NAMPT FOXO3 FOXO1 PARP1 NAD+ biosynthetic pathways WP3645 SIRT2 SIRT5 SIRT4 ACMSD QPRT NADSYN1 SIRT3 SIRT1 NAPRT NMNAT1 PARP1 PARP4 BST1 IDO1 CD38 TDO2 TNKS TNKS2 SIRT6 NAMPT SIRT7 PARP2 NAD+ metabolism WP3644 NADK SIRT2 NMNAT3 SIRT5 SIRT4 NMNAT2 SIRT3 SIRT1 NRK NMNAT1 PARP1 NT5E CD38 SIRT6 NAMPT SIRT7 Nanomaterial induced apoptosis WP2507 FADD PRF1 ENDOG AIFM1 HTRA2 BAX BCL2 FAS CASP7 FASLG CASP8 BAK1 CASP9 APAF1 BID CYCS CASP3 DIABLO CFLAR CASP6 Nanomaterial-induced inflammasome activation WP3890 TLR4 NFKB1 IL1B NOX1 CASP1 PYCARD CTSB Nanoparticle triggered autophagic cell death WP2509 ATG5 BECN1 TSC1 ATG9B ATG3 ATG16L1 ATG14 ATG12 ATG10 BCL2 SH3GLB1 MAP1LC3A ATG4A INS AMBRA1 TSC2 INSR VMP1 UVRAG CHAF1A ULK1 ULK2 ATG7 Nanoparticle triggered regulated necrosis WP2513 TNFRSF1A FADD FTL CASP8 TNF PLA2G4A MAPK8 RIPK1 RIPK3 TRADD TICAM1 PARP1 Nanoparticle-mediated activation of receptor signaling WP2643 NRAS SOS1 HRAS AREG GRB2 MAPK14 COL1A1 MAPK8 EGFR MAPK1 MAPK12 ITGA1 RAF1 TLN1 PIK3CD PXN FN1 AKT3 MAPK11 MAPK9 MAPK10 ITGB1 MAPK13 MAP2K1 SRC PTK2 KRAS MAP2K2 ncRNAs involved in STAT3 signaling in hepatocellular carcinoma WP4337 NFKB1 RELA STAT3 IL6ST IL6R IL11RA JAK1 IL6 JAK2 JAK3 IL11 ZEB1 SOX4 ncRNAs involved in Wnt signaling in hepatocellular carcinoma WP4336 TPTEP2-CSNK1E CXXC4 CSNK2B CSNK1A1L WNT10B FRAT2 WNT2B NOTUM NKD2 MTDH WNT11 DVL1 CSNK2A2 CCND1 DKK4 TCF7L1 CSNK2A1 KREMEN1 MYC CTNNB1 WNT10A CSNK1E EZH2 CSNK1A1 DKK2 SFRP5 SFRP4 SOX7 ROR2 DVL3 DVL2 SOX17 WIF1 PORCN KLF4 FOSL1 WNT4 CER1 NKD1 APC LEF1 FRAT1 SOST JUN AXIN1 CHD8 SENP2 WNT16 CCND2 CTNNBIP1 ELAVL1 CCND3 CSNK2A3 FZD3 FZD5 NLK FZD1 LRP6 WNT3 DKK1 WNT3A LRP5 WNT2 WNT6 WNT5A SERPINF1 FZD8 WNT7B WNT7A FZD9 FZD6 SFRP2 FZD7 SFRP1 WNT1 GSK3B WNT5B FZD2 CTBP2 ROR1 CTBP1 RYK FZD10 TCF7 PLAU TCF7L2 Neovascularisation processes WP4331 TGFB3 NFKB1 TGFBR1 NFKB2 KITLG SMAD5 TGFB1 EPHB4 TGFB2 SMAD9 KIT FLT4 EPHB2 MAPK8 ACVRL1 HIF1A SMAD1 SMAD2 MAPK1 KDR MAPK3 SMAD3 PDGFB CXCL12 RELA RELB CXCR4 JAG1 ANGPT1 DLL4 NOTCH1 AKT1 MAPK9 NOTCH3 REL NOTCH4 MMP9 Nephrogenesis WP5052 WNT9B PAX2 ALDH1A2 OSR1 MEIS1 FOXD1 FGF8 JAG1 WNT4 SIX2 GREB1L BMP7 RSPO1 RSPO3 NOTCH2 TCF21 FGF20 Nephrotic syndrome WP4758 LMX1B CD2AP PODXL TRPC6 COL4A4 ALG1 COL4A3 LAMB2 ARHGDIA PDSS2 SCARB2 E2F3 WDR73 ARHGAP24 ITGA3 CD151 COQ8B COQ6 MYO1E SYNPO NPHS1 MYH9 APOL1 PAX2 PMM2 ITGB4 LMNA CUBN YARS INF2 CTLA4 GPC5 WT1 PLCE1 COQ2 CYP11B2 SMARCAL1 COL4A5 ANLN EMP2 ACTN4 PTPRO TTC21B NPHS2 ZMPSTE24 Netrin-UNC5B signaling pathway WP4747 PTPN11 TNF NTN1 ARHGEF12 DAPK1 PRKCA CCL2 CASP3 INPP5D YAP1 UNC5B ITGB4 MAPK1 MAPK3 SELE VCAM1 MYF5 PLEKHH1 ALPL AKT1 SRC PTK2 JUN AGAP2 ICAM1 PPP2R1B MAPK14 COL1A1 ROBO4 RAC1 KDR TP53 RAF1 PPP1CA IL1A NTN4 CIP2A PTK2B PIK3CA CTGF RGMA DCSTAMP RHOA NTN3 FYN CDH5 IL10 RLF PTPA NEO1 MAP2K1 MAP2K2 Neural Crest Cell Migration during Development WP4564 PAK3 TRIO STAT3 FOS PAK5 F2RL2 EPHB6 EPHB4 PAK2 NGFR ARF1 PIK3R6 EPHB3 EPHB2 EPHB1 PIK3R3 PAK4 RAC1 PIK3CG PIK3R4 PAK1 TWIST1 PIK3CA PIK3R5 PIK3CB PIK3CD TIAM1 RHOA NGEF AKT3 MMP2 AKT1 AKT2 BDNF MMP8 BUB1B-PAK6 MMP9 PAK6 CDH11 JUN Neural Crest Cell Migration in Cancer WP4565 PAK3 TRIO STAT3 FOS PAK5 F2RL2 EPHB6 EPHB4 SORT1 PAK2 NGFR ARF1 PIK3R6 EPHB3 EPHB2 EPHB1 PIK3R3 PAK4 RAC1 PIK3CG PIK3R4 PAK1 TWIST1 PIK3CA PIK3R5 PIK3CB PIK3CD TIAM1 NTRK2 RHOA NGEF KIDINS220 AKT3 MMP2 AKT1 AKT2 BDNF MMP8 BUB1B-PAK6 MMP9 PAK6 CDH11 JUN Neural Crest Differentiation WP2064 GFAP SNAI2 DVL1 RBPJ ZIC5 PHOX2B MYC CDH1 HDAC6 MYB GJB1 HDAC5 DVL3 DVL2 LHX2 TWIST1 HDAC11 NOTCH1 NOTCH2 OLIG3 TBX6 NOTCH3 DLX5 NOTCH4 LHX5 AXIN1 AXIN2 CDH2 BMP4 HDAC10 BMP7 FZD3 HDAC4 HDAC8 DCT TCF4 SMAD1 SOX5 SOX10 ISL1 SOX9 MSX1 NEUROG1 HDAC3 WNT8A ID1 WNT1 RHOB CDH7 CDH6 CTBP2 ASCL1 MPZ HES1 HAND1 OLIG1 DMBX1 TCF7L1 CTNNB1 HDAC7 MSX2 OLIG2 PAX3 HOXB1 HES5 COL11A2 DLL4 HEY2 ETS1 ITGB1 GBX2 TFAP2B NFKB1 NFKB2 MBP FGF19 ZIC1 DLL1 FGF8 HDAC2 MIA HDAC1 PAX7 TFAP2A COL2A1 FOXD3 FGF2 LHX1 WNT3A MITF PMP22 HDAC9 FGFR2 HOXA1 FGFR3 TLX2 FGFR1 GSK3B PRTG DLL3 SNAI1 Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway WP4577 PLA2G6 RB1CC1 PRKAA1 BECN1 STK11 PIK3C3 TSC1 DEPTOR ATP13A2 FA2H ATG12 WIPI1 SPTLC1 PANK2 ATG10 DCAF17 C19orf12 CP COASY GTPBP2 ATG4A RPTOR ATG101 MECP2 RHEB ACACA ULK1 ATG7 ATG5 SCP2 MLST8 PIK3R4 ATG13 WDR45 ATG3 ATG16L1 ATG14 FTL WIPI2 AKT1S1 ATG2A MAP1LC3A MTOR TSC2 Neuroinflammation WP4919 TLR4 NFKBIA RELA FOS CHUK MAPK14 MTOR MAPK8 COX1 COX2 NOS2 ASCC1 JUN Nicotine Activity on Dopaminergic Neurons WP1602 SLC18A2 TH CHRNA6 PPP1CA GNB1 GNAI1 CDK5 CHRNB2 GNG2 DDC CHRNA5 CHRNA4 CHRNA3 PRKACA ADCY2 DRD4 KCNK3 DRD3 KCNK9 DRD2 PPP1R1B Nicotine Metabolism WP1600 FMO3 CYP2B6 UGT1A9 AOX1 UGT1A4 CYP2A6 NLR Proteins WP288 CHUK EPHB2 RELA MAP3K7 MAPK8 IKBKG IKBKB CD40 ERBIN NO metabolism in cystic fibrosis WP4947 PRMT3 PRMT1 PRMT6 DDAH2 PRMT2 DDAH1 PRMT8 PRMT7 PRMT5 NOS1 NOS2 CARM1 NOS3 NO/cGMP/PKG mediated Neuroprotection WP4008 ACTN2 PPID NFKB1 NFKBIA TNF CREB1 CNGA4 CNGA3 CNGA2 BAD XIAP CNGA1 BCL2 CNGB1 IFNG GUCY1B1 GUCY1A1 IL1B CNGB3 PDE2A GRIN2D PDE3A NOS1 GRIN2C NOS2 GRIN2B CAMK2A CAMK2B GRIN2A NOS3 NEFL CAMK2D GRIN1 CAMK2G PRKG2 NPR1 RELA GUCY1A2 DLG4 CASP9 AKAP9 CALM1 CYCS TSPO NPPA CALM2 NPPB Non-genomic actions of 1,25 dihydroxyvitamin D3 WP4341 SP3 PRKCD PRKCE PRKCG PRKCH TNF NRAS IFNA2 JAK1 SP1 PLCG2 PRKCA CCL2 PRKCB CD40 CD40LG TLR4 TYK2 TNFRSF1A MAPK1 MAPK3 MAPK7 CYP27B1 NOD2 CYP24A1 TLR2 PRKCZ IL6 OAS2 IFI27L2 ETS1 PRKCQ MED1 KRAS JUN NFKB1 NFKB2 STAT2 RXRA STAT1 VDR RXRG RXRB HRAS IFNG MAPK14 DEFB4A CXCL8 MAPK8 ISG15 CAV1 CAMK2A CAMK2B CAMK2D CAMK2G PLCB2 PLCB3 MAPK12 PLCB4 PLCD1 RSAD2 RELB IKBKB PLCB1 IFI44L PLCE1 TLR8 CAMP MAPK11 MAPK9 MAPK13 Non-homologous end joining WP438 PRKDC XRCC6 WRN NHEJ1 DCLRE1C XRCC5 LIG4 POLL POLM XRCC4 Non-small cell lung cancer WP4255 PRKCG RASSF1 NRAS CDK6 CRABP2 CRABP1 FHIT CDK4 CCND1 BRAF JAK3 ALK PLCG1 PRKCA PLCG2 RASSF5 PRKCB BID STK4 CASP3 FOXO3 MAPK1 MAPK3 CDKN2A CDKN1A CASP8 ARAF CASP9 AKT1 AKT2 CYCS E2F1 KRAS GADD45B PDK1 RXRA SOS1 RXRG STAT3 RXRB HRAS BAD RARB GADD45G EGF GRB2 BAK1 E2F3 E2F2 PIK3R3 POLK EGFR PIK3R1 PIK3R2 TP53 TGFA RAF1 EML4 ERBB2 PIK3CA PIK3CB BAX PIK3CD DDB2 AKT3 STAT5B SOS2 STAT5A MAP2K1 MAP2K2 RB1 GADD45A Nonalcoholic fatty liver disease WP4396 MLXIP MAP3K11 NDUFA1 NDUFA2 NDUFA3 COX6B1 TGFB1 MLXIPL NDUFS8 COX6A1 BCL2L11 NDUFV2 NDUFA11 FAS FASLG UQCRQ CDC42 INS NDUFA12 NDUFS2 CCL2 BID NDUFS3 NDUFV1 NDUFS4 NDUFS5 NDUFS6 COX6A2 IRS2 COX8A COX7C ITCH ADIPOR1 COX7B COX7A2 COX7A1 COX6C COX7B2 UQCR10 NDUFA4 NDUFV3 NDUFA5 INSR MAP3K5 TRAF2 PRKAA1 RXRA PRKAA2 PRKAB1 PRKAB2 PKLR PRKAG2 NDUFS7 NDUFB11 COX5A PIK3R1 PIK3R2 PRKAG1 RELA SDHA IL1A IKBKB ADIPOQ PIK3CA PIK3CB PIK3CD CYTB COX6B2 BBC3 COX8C AKT3 MAPK9 COX1 COX2 COX3 IRS1 DDIT3 TNF PPARA SDHC SOCS3 SDHB SMAD7 SDHD UQCR11 IL1B CASP3 LEP LEPR MLX CYC1 ERN1 TNFRSF1A XBP1 NR1H3 SREBF1 VCAM1 UQCRHL IL6R IL6 CASP7 PRKAG3 CASP8 ADIPOR2 AKT1 AKT2 CYCS NDUFA4L2 JUN UQCRC2 UQCRC1 NFKB1 UQCRFS1 COX7A2L UQCRH NDUFC2-KCTD14 UQCRB NDUFA10 NDUFAB1 COX4I2 NDUFB1 NDUFB2 NDUFB3 CXCL8 BAK1 MAPK8 PIK3R3 NDUFA6 VMP1 NDUFA7 RAC1 NDUFA8 NDUFA9 NR1H4 CYP2E1 EIF2AK3 CEBPA BAX NDUFB10 COX4I1 EIF2S1 GSK3B NDUFC1 GSK3A NDUFC2 NDUFS1 ATF4 NDUFA13 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 COX5B NDUFB9 Notch Signaling Pathway Netpath WP61 TLE1 HES1 CUL1 CIR1 NUMB PSEN1 PSEN2 EP300 FHL1 GATA3 RBPJ CCND1 JAK2 MYC MAML2 ADAM17 JAG2 HIF1A MAML1 MAGEA1 HES5 SPEN ITCH FBXW7 SAP30 CDKN1A DLL4 MAML3 HEY2 PSENEN NOTCH1 AKT1 MAPT NOTCH2 APH1B NOTCH3 NOTCH4 SRC NFKB1 SNW1 RING1 STAT3 DLL1 HDAC2 HDAC1 HES6 PTCRA NCSTN HEY1 APH1A LCK PIK3R1 PIK3R2 NCOR2 SKP1 NCOR1 JAG1 NUMBL GSK3B DTX1 DLL3 Notch Signaling WP268 HES1 DTX2 KAT2B NUMB PSEN1 PSEN2 DLL1 HDAC2 HDAC1 RBPJ DVL1 PTCRA NCSTN DTX4 INPP5K APH1A ADAM17 DVL3 LFNG JAG2 DVL2 KAT2A MAML1 NCOR2 MFNG HES5 JAG1 NUMBL RBPJL DTX3 DTX3L DTX1 DLL4 CTBP2 CTBP1 MAML3 CREBBP NOTCH1 KCNJ5 APH1B NOTCH2 RFNG DLL3 NOTCH3 NOTCH4 NOTCH1 regulation of endothelial cell calcification WP3413 VEGFA ITGA1 MGP DLL1 JAG1 FGFR3 SOX6 GJA5 DLL4 ALPL NOTCH1 SAT1 CALU PLAT DLL3 LPAR1 JAG2 Novel intracellular components of RIG-I-like receptor (RLR) pathway WP3865 FADD TNF DDX3Y PIN1 IFNE ATG12 DHX58 IFNA1 DDX3X TANK MAVS ATG5 TBKBP1 MAP3K7 TKFC TBK1 CHUK CASP8 CYLD CASP10 RIPK1 MAP3K1 TRAF3 IKBKE TRAF2 NFKB1 TRAF6 IFIH1 NFKBIA NFKBIB IRF3 SNW1 DDX58 NLRX1 IFNK SIKE1 IFNG MAPK14 IFNB1 CXCL8 MAPK8 ISG15 MAPK12 AZI2 RELA CXCL12 TMEM173 IKBKB OTUD5 RNF125 MAPK11 IKBKG IRF7 MAPK9 MAPK10 MAPK13 DDX17 TRIM25 TRADD CXCL10 NRF2 pathway WP2884 HGF SLC2A6 SERPINA1 TGFBR2 PRDX6 CES1 TGFB1 SLC39A10 SLC39A13 TGFB2 NRG1 GSTM1 CYP4A11 GSTA4 GSTA3 CBR1 CBR3 TXNRD3 SLC2A12 GSTM5 ABCC4 GSTM4 SLC2A7 GSTM3 GSTM2 TXNRD1 SRXN1 PDGFB SLC6A17 EPHA3 TXN GGT1 GSTT2 GSTP1 BLVRB SLC39A9 SLC2A1 SLC2A3 SLC2A2 SLC5A7 SLC2A4 SLC2A5 RXRA SLC6A3 ME1 SLC6A2 SLC6A6 SLC6A4 CES5A ADH7 GGTLC1 SLC5A9 SLC39A12 CES2 UGT1A3 SLC5A2 UGT1A1 SLC5A1 UGT1A4 SLC5A3 GCLC SOD3 SLC5A5 SLC5A4 SLC6A1 PRDX1 GGT2 SLC6A13 SLC2A14 SLC6A16 SLC39A4 SLC5A10 HSPA1A SLC6A15 GCLM ABCC2 ABCC3 SLC6A8 SLC6A7 SLC6A9 SLC6A11 SLC2A9 MAFG UGT2B7 HSP90AA1 SLC2A8 SLC39A8 SLC39A2 MAFF HMOX1 CES4A SLC39A3 LOC102724197 ABCC5 SLC6A20 KEAP1 SLC5A8 SLC5A12 NFE2L2 GSTA5 SLC7A11 SLC6A5 GPX3 GPX2 SLC39A1 CES3 HSP90AB1 FTL UGT1A9 PPARD PGD MGST2 MGST3 SLC39A7 CYP2A6 SLC2A11 FTH1 SLC39A6 AGER SLC39A11 DNAJB1 UGT1A6 SLC5A11 UGT1A7 SLC2A13 ALDH3A1 SLC2A10 SLC6A19 HBEGF EGR1 SLC39A14 GGTLC2 PTGR1 TGFA SLC5A6 FGF13 SLC6A14 GSTA2 GSTA1 NQO1 SQSTM1 SLC39A5 EPHA2 GSR G6PD SLC6A18 NRF2-ARE regulation WP4357 NFE2L2 CUL3 CEBPB PIK3CA HMOX1 MAF SLC7A11 GSK3B FYN EPHB2 GCLM MAPK8 AIMP2 YES1 PRKCA GSTA2 INSR GCLC NQO1 RBX1 SRC KEAP1 PGAM5 nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell WP5027 EIF3B EIF3C EIF2S2 EIF3A EIF3G EIF3H EIF3D EIF3F EIF3CL EIF2S1 EIF1AX EIF5 EIF1 EIF3I EIF3J EIF3E EIF2S3 Nuclear Receptors in Lipid Metabolism and Toxicity WP299 ABCB1 VDR ABCB4 PPARA CYP8B1 CYP7A1 CYP4B1 RARB CYP4A11 RARG CYP2B6 CYP3A4 ABCB11 RARA ABCG1 CYP2C9 NR1H4 ABCG5 NR1I3 NR1H3 ABCA1 CYP27B1 CYP2E1 CYP26A1 CYP24A1 CYP1A2 ABCD2 ABCC2 ABCC3 PPARD PPARG NR1I2 ABCD3 Nuclear Receptors Meta-Pathway WP2882 HGF FGFBP1 SLC2A6 PDE4B SMARCA1 SERPINA1 CYP8B1 CYP7A1 SLC39A10 SNAI2 NRG1 CYP4A11 CCND1 CYP3A5 MYC CYP3A4 NCOA1 PPARGC1A SLC2A12 DNER CCL2 ABCB11 SLC2A7 FOXO1 SERPINB9 CCL20 IRS2 PDGFB SRXN1 SLC6A17 ALOX5AP GGT1 NCOA6 SLC39A9 EDN2 SLC5A7 GADD45B PSMC5 NR0B2 BHLHE40 PDK4 RXRA CAVIN2 ME1 SPINK13 CES5A ADH7 GGTLC1 SLC27A5 ANKRD1 ETNK2 KTN1 ACAA1 POLK PRDX1 CYP4F12 ACADM SERPINB2 NRIP1 NCOA3 CPT1A SLC2A14 SLC6A16 SULT1A1 PLK2 HSPA1A SLC6A15 ABCC2 IL17B ABHD2 UGT2B4 CUL1 MAFG SEC14L1 UGT2B7 CDC37 TNF HSP90AA1 GCC1 CES4A CDK4 SRPX2 IL2 FGD4 DNAJC15 CPT2 IL1B NR3C1 ABCC5 B3GNT5 SULT2A1 ACOX1 SLC6A20 SLC5A8 SLC5A12 NFE2L2 S100P NR1H3 SREBF1 SERTAD2 GSTA5 GPAM CDKN1C SLC39A1 CES3 HSP90AB1 CDKN1B UGT1A9 CPEB4 TNFAIP3 PTGS2 SLC39A7 SRC SLC2A11 DNAJC7 NFKB2 FTH1 AGER TSC22D3 DNAJB1 IFNG ADGRF4 HBEGF RGS2 EGR1 SLC26A2 EGFR SMC1A MYOF GGTLC2 PTGR1 TGFA SLC27A1 IL12B IL12A CDC42EP3 EHHADH IL11 FGF13 CDK1 PTGES3 SLC6A14 GSTA2 PTPA GSTA1 NQO1 SLC39A5 EPHA2 GSR SLC6A18 TGFBR2 PRDX6 TGFBR3 CES1 EP300 IGFBP1 TGFB1 SLC39A13 TGFB2 AHR GSTM1 GSTA4 CBR1 GSTA3 CBR3 TXNRD3 SPRY1 GSTM5 NCOA2 ABCC4 GSTM4 ANGPTL4 GSTM3 GSTM2 TXNRD1 THBD SRGN LRRC8A EPHA3 STOM TXN APOA5 SLC7A5 GSTT2 DBI TNS4 GSTP1 BLVRB SLC2A1 ARNT SLC2A3 SLC2A2 SLC2A4 SLC2A5 SLC6A3 SLC6A2 SLC6A6 STAT3 SLC6A4 SLC5A9 ACKR3 SLC39A12 FKBP5 FABP1 UGT1A3 CES2 SLC5A2 UGT1A1 SLC5A1 UGT1A4 SLC5A3 GCLC SOD3 SLC5A5 SLC5A4 IP6K3 SLCO1B1 SLC6A1 GGT2 MFGE8 SLC6A13 AHRR SLC39A4 SLC5A10 GCLM ABCC3 SLC6A8 SLC6A7 GPR153 CAP2 SLC6A9 AKAP13 SLC6A11 SLC2A9 HES1 POU5F1 KAT2B PPARA SLC10A1 SLC2A8 SLC39A8 SLC39A2 MAFF FASN HMOX1 PRRG4 SLC39A3 SLCO2B1 LOC102724197 SP1 KEAP1 ABCG8 ABCG5 ARL5B SLC7A11 SLC6A5 GPX3 JUNB GPX2 JUND CYP1B1 CYP1A2 FTL CYP1A1 EPB41L4B PPARD AMIGO2 MGST1 MGST2 PCK1 PGD MGST3 BIRC2 NR1I2 SCD CYP2A6 JUN PLTP ABCB1 ABCB4 FGF19 VDR AIP PPP1R14C ESR1 SLC39A6 BAAT BIRC3 CYP2C19 ALAS1 SLC39A11 CYP2B6 UGT1A6 SLC5A11 UGT1A7 APOA1 SLC2A13 APOA2 CYP3A7 ALDH3A1 SLC2A10 SLC6A19 NAV3 ENC1 CYP2C9 NR1H4 SLC39A14 SCP2 NR1I3 PMP2 SLC5A6 BAX APOC3 KLK15 SCNN1A ZIC2 SLC19A2 SQSTM1 G6PD Nuclear receptors WP170 RORC THRB NR2E1 PGR THRA RXRA NR2F2 VDR NR2F1 PPARA RXRG RXRB NR0B1 ESR1 NR5A2 NR4A1 NR2C2 RORA RARB RARG NR4A2 ESRRB ESRRA NR3C1 RARA NR1H2 NR1I3 NR1D2 NR1H3 ESR2 NR2F6 HNF4A AR ROR1 PPARD PPARG NR1I2 NR5A1 Nucleotide Excision Repair WP4753 CUL4A MNAT1 RFC1 RFC2 RFC3 CDK7 ERCC6 ERCC8 CUL4B ERCC5 ERCC4 ERCC3 GTF2H2 GTF2H1 POLE4 POLD3 ERCC2 RBX1 GTF2H4 POLD4 GTF2H3 LIG1 GTF2H5 PCNA GTF2H2C ERCC1 DDB2 DDB1 CETN2 RPA1 RFC4 POLD1 RFC5 RAD23A POLD2 POLE3 RAD23B RPA3 CCNH POLE RPA2 XPA POLE2 XPC Nucleotide GPCRs WP80 P2RY4 P2RY6 ADORA1 ADORA2A ADORA2B LPAR6 P2RY1 LTB4R P2RY2 ADORA3 LPAR4 Nucleotide metabolism WP404 RRM2 RRM1 PRPS1 POLA1 HPRT1 IMPDH1 RRM2B ADSL ADSS POLB POLD1 SAT1 DHFR PRPS2 NME2 SRM POLG OAZ1 MTHFD2 Nucleotide-binding Oligomerization Domain (NOD) pathway WP1433 DUOX2 NOD1 ACAP1 NAIP NFKBIA AIM2 MEFV HSP90AA1 PYCARD NLRP3 SUGT1 XIAP NLRP4 IL1B CASP1 RIPK2 PRDM1 RAC1 CARD9 CASP5 NLRP12 CARD8 AAMP RELA NLRC4 NOD2 IKBKB NLRP1 NLRP10 NLRP7 CHUK CASP7 CASP8 NLRP2 CASP9 NDUFA13 IKBKG CARD6 COPS6 IL18 ERBIN Oligodendrocyte specification and differentiation, leading to myelin components for CNS WP4304 MAG MBP TNF OLIG1 BMP2 CXCL2 BMP4 FGF2 IGF1 IL1B SHH NKX2-2 LIF OLIG2 MOG SOX5 NKX2-6 PDGFB SOX10 PLP1 MYT1 SOX9 CNTF SOX6 CNP CXCL1 SOX8 OMG ASCL1 GLI2 Omega-3/Omega-6 FA synthesis WP4723 ACSL1 PLA2G6 ACOX3 FADS2 PLA2G4A PLA2G5 FADS1 ACSL4 ACSL3 ACOT2 PLA2G4B ELOVL2 ELOVL5 ACOX1 Omega-9 FA synthesis WP4724 ACSL1 FADS2 FADS1 ELOVL6 ELOVL1 FASN ACSL4 ACSL3 ACOT2 SCD5 ELOVL3 ELOVL2 ELOVL5 SCD Oncostatin M Signaling Pathway WP2374 PRKCD PRKCE PRKCH PTPN11 FOS CREB1 OSMR SOCS3 RPS6 JAK1 JAK2 CDK2 JAK3 PRKCA CCL2 PRKCB CASP3 TYK2 HIF1A MAPK1 MAPK3 IL6ST CYR61 JUNB JUND PXN CDKN1B CASP7 MTOR AKT1 SRC KRAS NFKB1 VEGFA NFKBIA STAT1 SOS1 STAT3 HRAS RICTOR GRB2 MAPK14 MAPK8 EGR1 LIFR PIK3R1 SERPINE1 TIMP3 RELA SHC1 TP53 RAF1 MMP13 PTK2B CEBPB LDLR STAT5B MMP1 MAPK9 MMP3 OSM IRS1 MAP2K1 MAP2K2 PIAS3 One-carbon metabolism and related pathways WP3940 SHMT2 PCYT1B SHMT1 BHMT PLD1 MTHFR TYMS MAT1A MAT2A GPX5 DMGDH GPX3 DNMT3A GPX2 GPX1 GPX6 GPX4 CEPT1 CHKB GAD2 GAD1 BHMT2 CSAD BAAT CDO1 ETNK1 ETNK2 CHPT1 GPX7 SOD1 CHDH PCYT2 GCLC SOD3 DNM1 SOD2 MTR SARDH CHKA PCYT1A CTH AGXT2 DHFR2 AHCYL1 BCAT1 BCAT2 GCLM CBSL GNMT GSS PEMT GSR One-carbon metabolism WP241 SHMT2 MTHFD1L MTRR MTFMT AHCY SHMT1 ATIC AMT GLRX FOLH1 AHCYL2 BHMT DHFR MTHFD1 CHDH MTHFR MTR TCN2 MTHFD2 TYMS MAT1A FOLH1B DNMT3B DNMT3A DNMT1 MAT2B ALDH1L1 GART MTHFS FTCD Osteoblast differentiation WP4787 HES3 RBPJ PIK3R6 WNT4 NOTCH1 NOTCH2 NOTCH3 NOTCH4 FGF18 PIK3C2A PIK3C2B STAT1 PIK3C2G PIK3C3 BMP2 WNT16 BMP4 HES6 BMPR1A FZD3 FZD5 BMPR1B BMPR2 FZD1 WNT3 PIK3CG FZD4 WNT2 PIK3R1 SMAD1 WNT6 PIK3R2 WNT5A FZD8 WNT7B MAPK12 SMAD4 SOX9 FZD9 WNT7A FZD6 WNT8B FZD7 WNT8A PIK3CA PIK3CB WNT1 PIK3CD IHH MAPK11 MAPK9 FZD10 MAPK10 MAPK13 GLI3 GLI2 PTCH1 PRKCD WNT9B WNT9A PRKCE PRKCG PRKCH PRKCI PRKD1 SMAD5 WNT10B SMAD9 WNT2B WNT11 CTNNB1 WNT10A PRKCA PRKCB JAG2 PRKDC MAPK1 MAPK3 PIK3R4 MAPK4 MAPK6 MAPK7 PIK3R5 PRKCZ DLL4 HEY2 PRKCQ MYOD1 PPARG DLL1 FGF9 FGF8 FGF7 FGF6 FGF5 SMO FGF4 FGF3 FGF2 FGF1 MAPK14 HEY1 MAPK8 PIK3R3 LRP6 LRP5 WNT3A FGFR4 FGFR2 JAG1 FGFR3 FGFR1 RUNX2 FZD2 WNT5B FGF10 HES2 DLL3 Osteoblast Signaling WP322 ITGB3 TNFSF11 PDGFB PDGFRA PTH TNFRSF11B IBSP FGF23 BGLAP COL1A1 PDGFRB ITGAV PTH1R SLC17A2 Osteoclast Signaling WP12 TNFRSF11A ITGB3 GPR68 PDGFB TNFSF11 SPP1 TNFRSF11B ATP6V1G1 TRPV5 CTSK IFNB1 IFNAR1 AIMP2 MAPK8 SLC9A1 ACP5 Osteopontin Signaling WP1434 NFKB1 ITGB3 MAPK1 SPP1 MAPK3 RELA IKBKB MAP3K14 CHUK ITGAV PLAU MAP2K1 MMP9 Ovarian infertility WP34 ZP2 PGR ZP3 VDR SYNE2 FSHR ATM MLH1 PRLR SMPD1 CDK4 GJA4 TBP CCND2 DMC1 BMPR1B PTGER2 LHCGR DAZL EGR1 SMAD3 NRIP1 NCOR1 GDF9 ESR2 CEBPB INHA CDKN1B CYP19A1 FIGLA MSH5 NR5A1 Overview of interferons-mediated signaling pathway WP4558 STAT2 STAT1 IFNA5 IFNA4 IFNA2 IFNE IFNGR2 IFNL3 IFNL1 IFNA1 JAK1 IFNL2 JAK2 IFNGR1 IFNK IFNG IFNB1 IFNAR2 IFNAR1 PRKCA IRF9 TYK2 PIK3R1 IFNLR1 IFNA21 IFNA17 PIK3CA IFNL4 IFNA16 IFNA14 IFNA13 IFNA10 IL10RB IFNA8 IFNW1 IFNA7 IFNA6 Overview of leukocyte-intrinsic Hippo pathway functions WP4542 TEAD4 TEAD1 ITGAL TEAD3 FERMT3 CCR7 MAPK14 CD19 STK3 RASSF5 FOXO4 KNSTRN NDRG1 VMP1 PRDM1 YWHAQ TAZ FOXO3 RAC1 YAP1 FOXO1 LATS1 TEAD2 MST1 LPL RAB13 STK38L LATS2 FOXO6 MOB1A RAP1A RHOA FYB1 SAV1 FOXP3 Overview of nanoparticle effects WP3287 ITGAD TNF COL4A1 HMOX1 BAX PIK3CD IL6 BCL2 CRP FN1 CCND3 CXCL8 CDH3 LAMA3 AKT3 PTGS1 PTGS2 NFRKB PTK2 Oxidation by Cytochrome P450 WP43 CYP4F3 CYP4X1 CYP7B1 CYP2U1 CYP11A1 CYP4F22 CYP8B1 CYP7A1 CYP4B1 CYP4A11 CYP3A5 CYP3A4 CYP46A1 CYP2S1 CYB5R4 CYP2J2 CYP2R1 CYP4F2 CYP4V2 CYP27B1 CYP27A1 CYP26A1 CYP24A1 CYP1B1 CYP4F11 CYP19A1 CYP1A2 CYP1A1 CYP17A1 CYP11B2 CYP11B1 CYP2A7 CYP2A6 CYP4F8 CYP27C1 CYP3A43 CYP2C8 CYP2C19 CYP20A1 CYP2B6 CYP2A13 CYP51A1 CYP3A7 CYP39A1 CYB5R2 CYP26C1 CYP2C9 CYB5R1 CYP4F12 CYP2F1 CYP2E1 CYB5B CYP2D6 CYP2C18 POR CYP4A22 CYP26B1 CYP2W1 CYB5R3 CYB5A CYP4Z1 Oxidative Damage WP3941 TRAF3 MAP3K9 TRAF2 NFKB1 TRAF6 TNF NFKBIE CR2 TRAF1 BAD BCL2 BAK1 CDC42 C1QA C1QB APAF1 C1QC C1R TDP2 CASP3 C1S C2 C3AR1 TNFRSF1B BAG4 PCNA CDKN1C CDKN1B CDKN1A C4B CASP9 MAP3K1 MAP2K4 CYCS TNK2 MAPK10 C5 MAPK13 C5AR1 GADD45A Oxidative phosphorylation WP623 NDUFA2 NDUFA3 GZMB NDUFS8 NDUFV2 NDUFA11 ATP5F1D ATP5F1E ATP5PB NDUFS2 ATP5MC1 ATP5MC2 NDUFS3 ATP5MC3 NDUFV1 NDUFS4 NDUFS5 NDUFS6 ATP5MF ND5 ND6 ATP5ME ATP5PF NDUFA4 NDUFV3 NDUFA5 ND1 ND2 NDUFA4L2 ND3 ND4 ND4L DMAC2L NDUFA10 ATP6 NDUFAB1 NDUFB1 NDUFB2 ATP5F1A ATP6AP1 ATP5PO NDUFA6 NDUFS7 NDUFA7 NDUFA8 ATP5PD NDUFA9 ATP5MG ATP6AP2 NDUFB10 NDUFC1 NDUFC2 NDUFS1 NDUFB4 NDUFB5 ATP5F1B NDUFB6 NDUFB7 NDUFB8 NDUFB9 Oxidative Stress WP408 NOX4 NFKB1 TXN2 NOX3 FOS HMOX1 CYBB UGT1A6 MAPK14 SP1 MT1X SOD1 GCLC MAOA SOD3 SOD2 TXNRD1 NFE2L2 XDH NFIX JUNB GPX3 GSTT2 GPX1 NOX5 CYP1A1 NOX1 MGST1 MAPK10 CAT NQO1 TXNRD2 GSR Oxysterols derived from cholesterol WP4545 RORC CH25H IL17F CYP7B1 GPR183 CYP8B1 ESR1 CYP7A1 EPHX2 AMACR BAAT INSIG1 SLC27A5 IL17D IL25 CYP3A4 CYP46A1 IL17C SLC27A2 CYP39A1 DHCR7 ACOX2 SCP2 NR1H2 ACOT6 ACOT1 ACOT12 ESR2 ACOT11 CYP27A1 ACOT9 ACOT2 AKR1D1 ACOT4 LBP HSD3B7 EBP IL17B ACOT13 NR1I2 ACOT7 THEM5 DBP AKR1C4 IL17A ACOT8 p38 MAPK Signaling Pathway WP400 MAP3K9 TRAF2 MAPKAPK5 TGFBR1 STAT1 PLA2G4A CREB1 HRAS MAPKAPK2 TGFB2 HSPB1 MYC GRB2 MAPK14 ELK1 CDC42 MKNK1 MAX RAC1 DAXX MEF2D SHC1 MAP3K7 RPS6KA5 HMGN1 MAP2K6 ATF2 RIPK1 MAP3K1 MAP2K4 MAP3K5 DDIT3 RASGRF1 TRADD p53 transcriptional gene network WP4963 TP53I3 XRCC5 MGMT SERPINB5 ERCC5 MLH1 TP53INP1 GLS2 ACAD11 FAS CPT1C TIGAR PIDD1 SESN1 SIVA1 APAF1 BTG2 SAT1 CCL2 NCF2 TRAF4 ZMAT3 ULK1 IRF9 THBS1 SLC7A11 DRAM1 SESN2 GPX1 CDKN1A RRM2B NOTCH1 ALDH4A1 SLC2A1 NANOG POLH FUCA1 ULK2 TNFRSF10D CX3CL1 PMAIP1 PRKAB1 PRKAB2 FANCC ICAM1 SMR3B ADGRB1 ADORA2B RPRM ISG15 POLK LIF PERP PML SERPINE1 TP53AIP1 ULBP1 ULBP2 BAX PTEN DDB2 BBC3 IRF5 CCNG1 MSH2 GADD45A XPC Pancreatic adenocarcinoma pathway WP4263 PRKCD PAK3 TGFB3 RPS6KB2 TGFBR1 RPS6KB1 TGFBR2 RALBP1 CDK6 PAK5 TGFB1 TGFB2 PAK2 CDK4 JAK1 CCND1 BRAF BCL2L1 BRCA2 CDC42 RALA PLD1 PAK4 RALB MAPK1 MAPK3 PEBP1 CDKN2A CHUK CDKN1A CASP9 ARAF MTOR AKT1 AKT2 RALGDS E2F1 KRAS GADD45B NFKB1 RAC2 RAC3 VEGFA STAT1 STAT3 BAD GADD45G EGF BAK1 E2F3 E2F2 MAPK8 PIK3R3 RAC1 POLK EGFR PIK3R1 PIK3R2 SMAD2 SMAD3 ARHGEF6 RELA SMAD4 TP53 PAK1 RAF1 TGFA IKBKB ERBB2 PIK3CA PIK3CB BAX TIAM1 PIK3CD RIPK4 RHOA DDB2 AKT3 IKBKG MAPK9 MAPK10 RAD51 DUSP6 BUB1B-PAK6 MAP2K1 PAK6 MAP2K2 GADD45A RB1 Parkin-Ubiquitin Proteasomal System pathway WP2359 PSMD6 CUL1 CASK TUBA3D SIAH2 SIAH1 TUBB2A TUBB HSPA9 HSPA8 GPR37 CASP1 SEPT5 SNCA TUBA1B UBA1 PSMD14 UBE2L3 TUBA8 TUBB3 TUBB4B TUBB4A PRKN FBXW7 TUBA3E PSMC6 PSMD1 PSMD2 PSMD3 UBE2J2 CASP8 UBE2G2 SNCAIP UBE2G1 TUBA1A PSMC1 PSMC2 PSMC3 PSMC4 TUBA1C PSMC5 UBE2L6 STUB1 TUBB6 HSPA14 PSMD11 PSMD12 PSMD13 UBE2J1 CCNE1 PSMD4 PSMD5 TUBB2B PSMD7 PSMD8 PSMD9 PSMD10 TUBA4A TUBA3C HSPA6 RNF19A TUBAL3 TUBB1 HSPA2 HSPA1L HSPA1B HSPA1A TUBB8 HSPA5 HSPA4 Parkinson's disease pathway WP2371 SYT11 ATXN2 GPR37 SNCA SEPT5 APAF1 UBA7 CASP2 UBA1 CASP3 CASP6 TH UBE2L3 PINK1 PRKN UBE2J2 CASP7 LRRK2 CASP9 SNCAIP UBE2G2 UBE2G1 CYCS PARK7 UBE2L6 SLC6A3 UCHL1 HTRA2 MAPK14 UBE2J1 CCNE1 CCNE2 MAPK12 UBB DDC EPRS MAPK11 MAPK13 Pathogenesis of SARS-CoV-2 Mediated by nsp9-nsp10 Complex WP4884 CD247 MMP25 PRG3 HLA-DRB1 HLA-DRA IL6 CRP FYN HLA-DRB5 LBP IGLL1 CXCL8 CD4 ZAP70 NKRF CD8A CD2 CD8B LCK CD3E CD3G Pathogenic Escherichia coli infection WP2272 NCK1 NCL ARPC4 ARPC5 TUBA3D OCLN ARPC1B ARPC3 TUBB2A ARHGEF2 LY96 TUBB CTNNB1 CDC42 PRKCA CDH1 TUBA1B KRT18 YWHAQ TLR4 TUBA8 ROCK2 TUBB3 WAS TUBB4B YWHAZ TUBB4A CLDN1 TUBA3E ARPC2 WASL TUBA1A ACTB ITGB1 TUBA1C CD14 ABL1 TLR5 TUBB6 ROCK1 HCLS1 ARPC5L ACTG1 ARPC1A TUBB2B TUBA4A NCK2 EZR TUBA3C TUBAL3 TUBB1 RHOA FYN CTTN TUBB8 Pathways affected in adenoid cystic carcinoma WP3651 HIST1H2AL MAGI1 SMARCA2 MAGI2 EP300 ATM BRCA1 MORF4L1 MYC KANSL1 IL17RD MYB MYBL1 FOXO3 PRKDC NFIB BCORL1 NSD1 TLK1 FOXP2 KDM6B JMJD1C BRD1 FBXW7 BCOR HIST1H1E ARID5B MAML3 CREBBP CNTN6 NOTCH1 KDM6A AKT1 MYCN INSRR SETD2 HRAS UHRF1 MGA CMTR2 CHEK1 DTX4 ARID4B MAX CHEK2 FGF16 SMARCE1 MYCBP ARID1A SMC1A KAT6A TP53 RAF1 NCOR1 FGFR4 ERBB2 PIK3CA CEBPA PTEN SRCAP CTBP1 ATRX MAP2K2 KMT2C ERBIN Pathways in clear cell renal cell carcinoma WP4018 SHMT2 TGFB3 TPI1 ACLY TSC1 DEPTOR EP300 TGFB1 FASN TGFB2 SHMT1 ALDOC KCNJ2 GPI ENO3 EFCAB3 ENO2 CDH13 PFKP KSR1 HIF1A PGK1 PLOD2 PDGFB PGK2 PDGFRA HK2 HK1 BHLHE41 CREBBP GAPDH MTOR SLC2A1 PGBD5 AKT1 ARNT TSC2 CAMK1 SETD2 LDHD VEGFA BAP1 ME1 SDSL ENPP3 STAT3 HK3 MDH1 PSAT1 GRB10 LDHA RPTOR FLT1 PGM1 PKLR PDGFRB RHEB PKM SDS ACACA EGFR CEP290 ACACB KDM5C RAPGEF5 MLST8 KDR PFKL PFKM PBRM1 ENO1 SSPN PHGDH TOX2 PTEN PGM2 LDHC AKT1S1 ALDOA ALDOB VHL SQSTM1 PSPH ZEB1 LDHB Pathways of nucleic acid metabolism and innate immune sensing WP4705 IFIH1 SAMHD1 TMEM173 IRF3 DDX58 RNASEL RNASEH2A OAS1 RNASEH2B ADAR IFNB1 CGAS RNASET2 TREX1 MAVS RNASEH2C Pathways Regulating Hippo Signaling WP4540 PRKD3 IGF1R CDC42 CDH1 TAZ LATS1 PDGFRA INSR PRKAA1 PRKAA2 PRKAB1 MET PRKAB2 CDH2 CDH20 KIT FLT4 FLT3 FLT1 PDGFRB PRKAG2 PRKAG1 PLCB2 SMAD2 PRKAR1A PLCB3 SMAD3 KDR PLCB4 MST1 PRKAR1B PRKAR2A CDH12 CDH10 NTRK1 CDH9 NTRK2 CDH8 RHOA CDH7 CDH6 CDH5 CDH4 CDH3 PRKACA PRKACB PRKACG TCF7 TCF7L2 CDH11 PRKCD PRKCE PRKCG PRKCH PRKCI TEAD4 NF2 TEAD1 TEAD3 NGFR TCF7L1 CDH18 CDH17 YY1AP1 CTNNB1 CDH16 CDH15 CDH13 PRKAR2B STK3 PRKCA PRKCB TEK TEAD2 CDH24 CDH22 LATS2 PRKCZ PRKAG3 LEF1 MTOR PRKCQ GNAI2 CDH19 GNA11 CSF1R RAC1 EGFR FGFR4 FGFR2 PLCB1 FGFR3 FGFR1 GNAS GNAQ GNAL GNAI3 EPHA2 PDGF Pathway WP2526 ARFIP2 NFKB1 PTPN11 NFKBIA STAT1 PLA2G4A SOS1 STAT3 FOS HRAS JAK1 GRB2 ELK1 PDGFRB MAPK8 PLCG1 SRF CDC42 RAC1 PIK3R1 PDGFA MAPK1 MAPK3 PDGFB SHC1 VAV2 RAF1 PAK1 TIAM1 RHOA CHUK MAP3K1 MAP2K4 WASL RASA1 COX2 MAP2K1 SRC JUN VAV1 PDGFR-beta pathway WP3972 STAT1 SOS1 STAT3 FOS HRAS JAK1 JAK2 GRB2 ELK1 PDGFRB PLCG1 EIF2AK2 MAPK8 SRF PRKCA PRKCB PIK3R1 MAPK3 SHC1 RAF1 PIK3CA STAT5B STAT5A MAP3K1 MAP2K4 STAT6 RASA1 MAP2K1 JUN Pentose Phosphate Metabolism WP134 RPE RPIA PGLS PGD TALDO1 G6PD TKT Peptide GPCRs WP24 TACR3 OXTR NPY4R SSTR1 TRHR SSTR3 SSTR2 TAC4 AVPR1A AVPR1B AVPR2 GALR1 TACR2 NPY1R NPY2R TACR1 NPY5R CCR10 NTSR1 C3AR1 TSHR CCR2 EDNRA CXCR4 CCR1 BRS3 CXCR3 FPR3 FPR2 GNRHR FPR1 CXCR5 CCKAR CCKBR SSTR5 SSTR4 GALR2 CXCR6 C5AR1 MC1R GHSR NTSR2 FSHR HCRTR2 HCRTR1 EDNRB CCR8 NMBR CCR7 CXCR2 CCR6 CXCR1 CCR5 CCR4 CCR3 ATP8A1 LHCGR OPRD1 OPRK1 OPRL1 OPRM1 GRPR MC5R GALR3 AGTR1 AGTR2 MC4R CX3CR1 CCR9 ACKR1 BDKRB1 BDKRB2 MC2R MC3R Peroxiredoxin 2 induced ovarian failure WP4873 STAR PRDX2 CYP11A1 MAPK10 CASP3 HSD3B2 BAX PARP2 Phase I biotransformations, non P450 WP136 PON1 CES2 PON2 CES1 PON3 ESD CES5A LIPA Phosphodiesterases in neuronal function WP4222 PDE3B PDE4A PDE4B PDE4C PDE4D PDE6A PDE6C LOC101929970 PDE6D PDE5A CREB1 CHRNA7 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 GUCY1B1 GUCY1A1 PDE1C PDE2A PDE3A NOS1 GRIN2D GRIN2C GRIN2B GRIN2A GRIN1 DRD2 DRD1 PDE8A PDE9A PDE1B PDE8B PDE6B PDE7A PDE6G PDE6H ADCY10 ADCY4 PPP1R1B GRIA1 ADORA2A CHRFAM7A PDE1A PDE12 PDE7B GUCY1A2 PDE10A ADCY1 ADCY2 ADCY3 PDE11A Phosphoinositides metabolism WP4971 MTMR1 MTMR3 MTMR2 MTMR6 SBF2 PLCH1 PLCG1 SACM1L PLCG2 SBF1 INPP5D PIP4P2 PIK3R4 MTMR4 MTMR11 MTM1 MTMR7 PIP4K2A MTMR8 MTMR9 PIP4K2B PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIP5K1A PIP5K1B MTMR10 PIP4K2C PIK3CG PLCB2 PLCH2 PLCB3 PLCB4 PLCD1 PLCD3 PLCB1 PIK3CA PIK3CB PIKFYVE PIK3CD PTEN PLCD4 PIP4P1 PLCE1 MTMR12 PLCZ1 PIP5K1C OCRL Photodynamic therapy-induced AP-1 survival signaling. WP3611 TNF FOS HSP90AA1 MCL1 CCND1 BCL2L11 IL2 BCL2 FAS FASLG BCL2L1 BID TNFRSF1A NFE2L2 TNFSF10 PDGFRA JUNB CDKN2A IL6 CDKN1A ATF2 BCL3 BMF MAP3K5 JUN TRAF2 TRAF6 TRAF5 FGF7 CCNA2 IFNG MAPK14 BAK1 CCNE1 ELK1 MAPK8 HBEGF EGFR MAPK12 TP53 BAX MAP2K6 MAP2K7 MAPK11 MMP2 MAP2K4 MAPK13 CFLAR MAP2K3 RB1 Photodynamic therapy-induced HIF-1 survival signaling WP3614 TGFB3 VEGFA PMAIP1 IGFBP3 EPO IGFBP2 IGFBP1 PDHA1 MCL1 HIF1AN BIRC5 BCL2A1 LDHA BCL2L1 BAK1 PKM BID NOS2 PGK1 HIF1A SERPINE1 PFKL TP53 SLC16A1 TGFA HK1 ANGPT1 BAX ANGPT2 EGLN1 BNIP3 BNIP3L SLC2A1 ARNT EDN1 PTGS2 SLC2A3 Photodynamic therapy-induced NF-kB survival signaling WP3617 NFKB1 TRAF6 NFKB2 VEGFA TNF ICAM1 CSF2 BIRC3 CCND1 IL2 CXCL2 BIRC5 BCL2A1 BCL2L2 CXCL8 IL1B CD40LG TNFRSF1A RELA SELE RELB EGLN2 VCAM1 IL1A IKBKB IL6 CHUK MMP1 PTGS2 MMP2 BIRC2 MMP3 REL CFLAR MMP9 Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling WP3612 NFE2L2 MAPK12 SRXN1 FOS CES1 EPHX1 HMOX1 LOC105369239 GCLM GSTP1 ABCC6 MAPK14 ABCC2 ABCG2 ABCC3 MAPK8 MAPK11 GCLC NQO1 ABCC4 MAPK13 NQO2 JUN KEAP1 Photodynamic therapy-induced unfolded protein response WP3613 PDIA6 UBE2E1 PPP1R15A HSP90B1 BCL2L11 TRIB3 CALR DNAJC3 DNAJB11 ERN1 XBP1 WARS EDEM1 NFE2L2 ATF6 SULT1E1 DNAJB9 EIF2A EIF2AK3 ASNS BBC3 ATF3 ATF4 NARS DDIT3 HSPA5 ERP27 Physiological and pathological hypertrophy of the heart WP1528 MYEF2 PRKCE STAT3 FOS MAPK14 MAPK8 PRKCB RAC1 LIFR CAMK2D GATA4 MAPK1 PPP3CA PPP3CB IL6ST AGT RHOA CTF1 EDN1 MAPK11 CALM1 NFATC4 CALM2 MAP2K3 JUN Phytochemical activity on NRF2 transcriptional activation WP3 NFE2L2 CEBPB PIK3CA HMOX1 MAF SLC7A11 EPHB2 GCLM MAPK8 AIMP2 PRKCA GSTA2 GCLC NQO1 KEAP1 PI3K-Akt signaling pathway WP4172 HGF TCL1B GNGT2 GNGT1 OSMR GNG11 GNG10 MCL1 CCND1 GNG7 BCL2 GNG5 MYC GNG4 BCL2L1 FASLG PKN3 LAMA1 GNG3 GNB3 GNB2 INS GNG13 MYB FOXO3 RBL2 NOS3 VWF GNG8 PDGFA PDGFB PDGFRA PIK3AP1 CHAD VTN INSR LPAR1 GHR MDM2 GH2 GH1 FLT4 FLT3LG RPTOR CD19 FLT3 FLT1 PDGFRB RHEB ITGA6 PIK3CG PIK3R1 PIK3R2 KDR RELA ITGA1 C8orf44-SGK3 ITGA2 PHLPP2 IKBKB PIK3CA PIK3CB PDPK1 PIK3CD PTEN CHRM2 CHRM1 FN1 CREB3L3 IRS1 MAP2K1 MAP2K2 ITGA9 CDC37 TSC1 NRAS IL3RA IFNA5 CREB1 IFNA4 HSP90AA1 IL3 CDK6 IL2RG IFNA2 IL2RB IFNA1 PRLR CDK4 IL2RA IL2 THEM4 CDK2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA7 PRL TEK ITGB3 ITGB4 ITGB5 ITGB6 CREB3L2 ITGB7 IL7 IFNA21 IFNA17 IL6R ANGPT1 ANGPT2 EFNA2 EFNA1 PDGFD IFNA16 IFNA14 PPP2R3C IL6 IFNA13 HSP90AB1 CDKN1B IFNA10 CDKN1A CHUK IL4R IFNA8 ATF6B IFNA7 CASP9 IL4 IFNA6 MTOR ATF2 ITGAV TSC2 ITGB1 PTK2 EFNA5 EFNA4 EFNA3 TNR NFKB1 SYK PPP2R2A TNXB TCL1A PPP2R2B COL4A4 FGF9 COL4A3 FGF8 COL4A2 FGF7 FGF6 COL4A1 FGF5 COL2A1 PPP2R1B FGF4 FGF3 EGF FGF2 COL1A2 FGF1 IFNB1 COL1A1 IFNAR2 IFNAR1 IL7R ITGB8 PPP2CA PPP2CB RAC1 EGFR FGF21 PPP2R1A LPAR6 TP53 COL6A6 RAF1 TGFA COL9A1 FGFR4 FGFR2 COL6A3 FGFR3 COL6A2 FGFR1 COL6A1 PHLPP1 GSK3B FGF14 FGF13 FGF12 COL4A6 LAMA2 FGF11 COL4A5 LAMA3 FGF10 PPP2R2C PPP2R3A PPP2R5A BDNF EPHA2 PPP2R5B PPP2R5C RELN PPP2R5D PPP2R5E CREB5 RPS6KB2 RPS6KB1 FGF22 LPAR3 IGF2 IGF1R RPS6 LAMB2 LAMB3 EIF4B BCL2L11 LAMC1 F2R EIF4E1B PIK3R6 IGF1 LAMC2 COL9A3 COL9A2 PPP2R2D LAMA4 LAMA5 EIF4EBP1 LAMB1 EIF4E ITGA11 THBS1 THBS3 G6PC3 THBS2 PPP2R3B TNC EIF4E2 GNG12 VEGFD ANGPT4 FGF18 FGF20 PRKAA1 PRKAA2 SOS1 MET EPO HRAS THBS4 LPAR5 TNN IBSP HSP90B1 KIT CCND2 PDGFC NTF3 CCND3 NTF4 CCNE1 SGK2 FGF17 LPAR4 CCNE2 MLST8 SGK3 DDIT4 NTRK1 NTRK2 EPOR AKT3 SOS2 G6PC2 CREB3 KITLG STK11 PKN1 PKN2 COL6A5 LAMB4 NGFR JAK1 BRCA1 JAK2 JAK3 PRKCA NGF TLR4 MAPK1 MAPK3 CREB3L1 PIK3R5 TLR2 GYS2 GYS1 CREB3L4 AKT1 PCK1 AKT2 PCK2 PGF KRAS SPP1 VEGFA FGF19 VEGFC VEGFB CSF3 FGF23 BAD CSF1R GNG2 CSF1 GRB2 COMP LAMC3 GNB4 SGK1 PIK3R3 GNB1 LPAR2 CSHL1 CSH2 CSH1 ATF4 CSF3R ITGA8 IKBKG GNB5 ITGA10 OSM G6PC PI3K-AKT-mTOR signaling pathway and therapeutic opportunities WP3844 PDK1 RB1CC1 NRAS RICTOR HRAS BAD GRB10 RPTOR RHEB FOXO4 PIK3R3 FOXO3 NOS3 FOXO1 ULK1 EIF4EBP1 PIK3CG PIK3R1 PIK3R2 ATG13 PIK3CA PIK3CB PTEN GSK3B CDKN1B MTOR TSC2 AKT1 TFEB KRAS PI3K/AKT/mTOR - VitD3 signaling WP4141 PFKFB4 RXRA VDR PRKAA2 RELA TSC1 HK3 HLA-DRA CYP24A1 PIK3CA IL12A PDHA1 GSK3B MYC LDHA CD80 MTOR CD86 IL10 AKT1 TSC2 SLC2A3 Pilocytic astrocytoma WP2253 BRAF PTPN11 GRB2 SOS1 RAF1 NF1 PKC-gamma calcium signaling pathway in ataxia WP4760 HOMER3 RYR3 GNA14 PDK1 TRPC3 PRKCG PLCB2 PLCB3 PLCB4 GRIA3 GRIA2 GRIA1 PLCB1 ATP2B2 GRM1 GNA11 GNAQ CACNA1A ITPR1 GRIA4 CA8 GNA15 Platelet-mediated interactions with vascular and circulating cells WP4462 TLR4 PF4 TGFB3 CCL5 SELE VCAM1 ICAM1 TGFB1 TLR2 TGFB2 TLR7 IL1B SELP CCL2 SELPLG CD40 CD40LG PPAR signaling pathway WP3942 PPARA CYP8B1 CYP7A1 ACSBG1 CYP4A11 CPT1C HMGCS2 CPT2 CPT1B ACOX1 ANGPTL4 NR1H3 LPL SORBS1 CYP27A1 APOA5 AQP7 GK2 DBI PPARD PLIN1 PPARG PCK1 OLR1 PCK2 SCD PLTP ACOX3 RXRA ME1 RXRG RXRB FABP7 FABP6 FABP5 ACSL6 FABP3 SLC27A5 SLC27A4 ILK FABP2 APOA1 FABP1 APOA2 FABP4 SLC27A2 ACAA1 ACOX2 ACSL5 ACSL1 ACADL ACADM SCP2 FADS2 SLC27A1 SLC27A6 CPT1A ADIPOQ PDPK1 UCP1 ACSBG2 ACSL4 ACSL3 EHHADH APOC3 MMP1 CD36 PPAR-alpha pathway WP2878 PLTP RXRA PPARA CYP8B1 CYP7A1 CDK4 CCND1 CYP4A11 MYC APOA1 FABP1 APOA2 CPT2 ACAA1 ACADM SCP2 NR1H3 SLC27A1 CPT1A APOA5 DBI EHHADH UGT1A9 APOC3 CDK1 KLK15 Prader-Willi and Angelman Syndrome WP3998 OXT MKRN3 TACR3 NDN CDK6 CDC6 CDK4 CCND1 MAGEL2 TUBGCP5 NHLH2 HTR2C INS HERC2 SNURF NGF TYR GABRR3 GABRB3 CDKN2C CDKN2B ATP10A PRKCZ CDKN2A GABRA5 GNRH1 NIPA1 SNRPN DLX5 PCM1 E2F1 MDM4 GHRL PCSK1 POMC GHRH GABRR2 NPAP1 CGA MDM2 KISS1 OCA2 GABRR1 CCND2 GABRG3 GABRG2 FSHB GABRG1 GABRD FEZ1 LHB UBE3A FEZ2 TP53 MSX1 NIPA2 SLC45A2 CYFIP1 BBS4 BDNF RB1 Pre-implantation embryo WP3527 POU5F1 TEAD4 SMARCA4 NKX2-1 ZSCAN4 KHSRP DPRX DNMT3L GATA3 GATA2 TCF7L1 LEUTX MTA3 ATP1A1 NLRP5 HMGA1 ZFP36L2 ESRRA CDH1 CELF3 MYBL1 FOXQ1 MOS KLF4 ZFP42 AQP3 AQP9 FOSB BARX2 ZAR1 SOX8 NANOG IRX5 DLX2 TFAP2B SIX3 PBX1 IRF4 FOXD1 HNRNPAB E2F5 ELAVL1 NANOGNB H2AFY2 ARGFX TPRX1 ZFP36 EGR1 NR3C2 BATF3 TBX3 MXD1 SOX11 PADI6 DPPA3 CDX2 SOX2 DDIT3 Pregnane X receptor pathway WP2876 DNAJC7 RXRA ABCB1 HSP90AA1 SRPX2 CYP2C19 CYP2B6 CYP3A5 UGT1A6 CYP3A4 CYP3A7 PPARGC1A UGT1A3 NCOA1 UGT1A1 UGT1A4 SULT2A1 NCOA2 ABCC4 FOXO1 SLCO1B1 CYP2C9 CYP4F12 NRIP1 NCOA3 UGT1A9 ABCC2 ABCC3 GSTA2 NR1I2 SRC PSMC5 CYP2A6 Primary focal segmental glomerulosclerosis (FSGS) WP2572 NCK1 LMX1B CD2AP PODXL UTRN TGFB1 FAT1 LAMB2 CR1 SCARB2 CTNNB1 PLCG1 MYO1E ITGA3 SYNPO YWHAQ LAMA5 TLR4 ITGB3 PAX2 ITGB4 PCNA CLDN1 WT1 TLN1 CDKN1C CDKN1B CDKN1A SMARCAL1 ITGAV VTN NOTCH1 AKT1 AGRN ITGB1 PTK2 MME TRPC6 CDH2 COL4A4 COL4A3 CTSL ILK KIRREL3 PARVA VCL CD151 KIRREL2 CAMK2B DNM1 KRT8 NPHS1 MYH9 DKK1 LRP6 LRP5 VIM INF2 MKI67 JAG1 WNT1 FYN PLCE1 CD80 COL4A5 IRF6 ACTN4 PTPRO PLAUR LIMS1 DAG1 NPHS2 Prion disease pathway WP3995 NFKB1 RXRA SMC3 STAT3 IRF4 CREB1 EP300 HSP90B1 TBP BATF BCL2 ELK1 SPI1 CASP3 MEF2C EBF1 PDIA3 CASP12 MAPK1 MAPK3 POU2F2 PAX5 RFX5 NCAM1 FGFR1 CHD2 FYN BCL11A RAD21 PRNP CTCF PTK2 HSPA5 Prolactin Signaling Pathway WP2037 SOCS1 RPS6KA2 PTPN11 RPS6KB1 TEC FOS SOCS3 RPS6 PRLR JAK1 JAK2 MYC PTPN6 CASP3 NOS2 EIF4EBP1 PRL IRS2 MAPK1 MAPK3 YWHAG VAV2 YWHAZ CISH FLNA PXN MTOR SIRPA AKT1 CTSD ITGB1 PTK2 SRC JUN VAV1 NFKB1 NFKBIA NFKBIB STAT1 SOS1 STAT3 AGAP2 HRAS GRB2 MAPK14 ELK1 PPIA MAPK8 PPIB ZAP70 RAC1 IRF1 PIK3CG PIK3R1 PIK3R2 PTPN1 RELA SHC1 PAK1 RAF1 ERBB2 PIK3CA PIK3CB GSK3B FYN STAT5B SOCS2 NEK3 STAT5A CBL MAPK9 GAB2 IRS1 MAP2K1 MAP2K2 PIAS3 Prostaglandin Synthesis and Regulation WP98 PPARGC1B S100A6 PLA2G4A PTGIS CYP11A1 HPGDS EDNRB PTGIR AKR1B1 CBR1 PTGER1 PPARGC1A PTGER2 PTGER3 PTGER4 ABCC4 PTGFR PRL PTGFRN HSD11B2 HSD11B1 SCGB1A1 MITF AKR1C3 PTGES SOX9 EDNRA PTGDS S100A10 AKR1C2 PTGDR TBXAS1 AKR1C1 HPGD ANXA1 ANXA2 PTGS1 PTGS2 EDN1 ANXA3 PPARG ANXA4 ANXA5 ANXA6 TBXA2R Proteasome Degradation WP183 PSMD6 UBE2D1 UBE2B UBE2D3 UBE2D2 HIST1H2AB UBC PSMB9 PSMB10 UBA7 UBA1 HLA-F HLA-E PSMC6 PSMD1 PSMD2 PSMD3 PSMC1 PSMC2 PSMC3 NEDD4 PSMC4 PSMC5 PSMA1 PSMA2 UCHL1 PSMA3 UCHL3 PSMA4 PSMA5 PSMD11 PSMD12 PSMD13 IFNG H2AFZ HLA-G H2AFX PSME3 PSMD4 PSMD5 PSMD7 PSMD8 PSMD9 PSMD10 PSMB2 RPN2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 UBB RPN1 HLA-C HLA-B HLA-A PSME1 PSMA6 PSMA7 PSME2 PSMB1 Proteoglycan biosynthesis WP4784 XYLT1 CHSY1 IMPAD1 XYLT2 CHST3 B4GALT7 EXT2 EXT1 PAPSS2 CANT1 B3GALT6 B3GAT3 CSGALNACT1 EXTL3 SLC35B3 CHST14 SLC26A2 SLC35B2 Proximal tubule transport WP4917 SLC9A3 ATP6V0D2 SLC47A1 ATP1A1 AQP1 ABCC4 SLC1A1 SLC6A20 SLC5A8 SLC12A4 ATP6V1H SLC26A6 SLC22A6 SLC3A2 SLC4A2 ATP1B1 ATP6V1G1 SLC13A3 CLTRN CA2 FXYD2 CA4 ATP6V1A ABCG2 SLC2A1 ATP6V1B1 ATP6V0C ATP6V1C1 SLC2A2 ATP6V1E1 SLC3A1 SLC22A7 ATP6V0E1 SLC7A8 SLC4A4 ABCB1 SLC20A2 SLC34A3 ATP6V1D ATP6V0B SLC16A10 SLC5A2 SLC6A19 SLC5A1 SLC22A11 SLC34A1 SLC5A5 SLC22A2 ATP6V0A4 SLC7A7 SLC22A8 SLC36A2 ATP6V1F SLC47A2 ABCC2 SLC7A9 SLC6A18 PTF1A related regulatory pathway WP4147 RBPJ HES1 PROX1 RBPJL KAT2B CTNNB1 PDX1 FGF10 NOTCH1 PTF1A NKX6-1 Purine metabolism and related disorders WP4224 PPAT PFAS MAT2A XDH PNP PRPS1 AMPD1 HPRT1 TPMT ATIC ITPA APRT ADA IMPDH1 RRM2B ADSL PAICS ADSS AOX1 GRM5 DGUOK GART Purine metabolism WP4792 XDH PNP PRPS1 AMPD1 HPRT1 ATIC ITPA APRT ADA IMPDH1 ADSL ADSS DGUOK Purinergic signaling WP4900 P2RX1 P2RX3 P2RX4 P2RX6 P2RX5 GNAI2 GNAI1 P2RX2 ADORA1 ADORA2A ADORA2B P2RY14 LPAR4 P2RY4 GNAT3 P2RY6 P2RY8 P2RY11 P2RY13 LPAR6 PANX1 GNAZ GNAT2 ADORA3 P2RY12 GNAT1 GNAS GNAO1 P2RY10 GNAI3 P2RX7 P2RY1 P2RY2 Pyrimidine metabolism and related diseases WP4225 RRM2 RRM1 TYMS CPS1 TYMP TK2 UMPS CAD DHODH GLS2 NT5C3A RRM2B DPYS DPYD UPB1 OTC NT5C Pyrimidine metabolism WP4022 POLA2 POLA1 TK2 TK1 CAD POLR1D DUT POLE4 NME1-NME2 ENTPD1 ENTPD3 RRM2 POLR3K CMPK1 RRM1 TYMS UPP1 POLR2A POLR2B POLR2C POLR2D LOC101060521 UMPS TWISTNB UCK2 CTPS1 POLR3C UCK1 RRM2B UCKL1 POLR3H POLD1 UPB1 POLD2 POLE POLE2 POLR3G POLR3F POLR2K POLR2L ENPP1 ENPP3 NME7 POLR2J2 POLR1A DCTPP1 DCTD DCK NT5M POLD3 CTPS2 POLR2E POLR3GL POLR3B CDA POLR2G PRIM1 PRIM2 POLR2H POLR2I PNPT1 UPRT POLR2J POLR3A POLD4 POLR1C POLR1E TYMP DHODH POLR3D DTYMK DPYS NME1 ZNRD1 DPYD NME2 POLR2J3 POLE3 NME3 NME4 CMPK2 NME6 POLR1B POLR3E NT5C RAC1/PAK1/p38/MMP2 Pathway WP3303 NCK1 ANGPTL1 PTPN11 NRAS MYC TNIP3 CTNNB1 NOS1 NOS2 YAP1 EIF4EBP1 FOXO1 TEK MAPK1 MAPK3 RS1 ANGPT1 ANGPT2 STMN1 PXN CHUK CASP7 CASP9 AKT1 ANGPT4 ITGB1 SRC PTK2 KRAS NFKB1 DOK2 NFKBIA SOS1 STAT3 HRAS TNIP2 BAD GRB14 TNIP1 BIRC5 GRB7 GRB2 MAPK14 CRK MAPK8 RAC1 EGFR PIK3R1 MAPK12 TP53 RELA PAK1 IKBKB ERBB2 PIK3CA BAX TIE1 FN1 STAT5B STAT5A MAPK11 IKBKG MMP2 MAPK9 RAD51 RASA1 MSH2 MAPK13 RalA downstream regulated genes WP2290 YBX3 EXOC2 EXOC8 RAC2 RAC3 NRAS CDC42 RALBP1 HRAS RALA RAC1 KRAS RANKL/RANK signaling pathway WP2018 NFATC1 FOS FHL2 PAPSS2 CALCR PLCG1 CDC42 TAB1 ACP5 MAPK1 MAPK3 LYN MAP3K7 TNFRSF11B VCAM1 CHUK MTOR AKT1 AKT2 PTK2 SRC JUN TRAF3 TRAF2 NFKB1 TRAF6 TNFRSF11A TRAF5 NFKB2 SYK NFKBIA STAT1 ICAM1 TRAF1 CTSK MAPK14 MAPK8 SPI1 RAC1 PIK3R1 PIK3R2 MITF TNFSF11 RELA RELB IKBKB TAB2 MAP2K6 MAP2K7 IKBKG CBL MAPK9 GAB2 SQSTM1 MAP2K1 RAS and bradykinin pathways in COVID-19 WP4969 NFKB1 VDR TNF ROCK1 KLK1 KLKB1 CYP3A4 SERPING1 IL1B NOS1 NOS3 ACE PRKG1 SERPINE1 MAPK1 NPR1 REN IL1A CYP24A1 ACE2 AGT F12 AGTR1 AGTR2 CPN1 KNG1 RHOA BDKRB1 BDKRB2 Ras signaling WP4223 PTPN11 RASSF1 GNGT2 GNGT1 PLA2G2D RALBP1 HTR7 GNG11 GNG10 RASAL2 IGF1R GNG7 PLA2G12A GNG5 GNG4 BCL2L1 FASLG GNG3 GNB3 GNB2 PLA1A GNG13 CDC42 RASSF5 RALA SHC4 RALB GAB1 RRAS2 SHC2 GNG8 CALML5 PDGFRA PLA2G2F RGL1 GNG12 PLA2G4F RRAS CALM1 INSR PLA2G2E CALM2 CALM3 PLA2G6 SHOC2 PLA2G10 ABL1 SYNGAP1 PLA2G2A BRAP PLA2G4A ABL2 MET SOS1 PLA2G5 HRAS KIT PLA2G4D FLT4 FLT3 FLT1 CALML3 PDGFRB RASGRP2 PLA2G1B PIK3R1 RAPGEF5 PIK3R2 KDR RELA PAK1 IKBKB PIK3CA JMJD7-PLA2G4B ARF6 PIK3CB TIAM1 PIK3CD NTRK1 NTRK2 RHOA PLA2G4B PRKACA AKT3 KSR2 PRKACB SOS2 PRKACG RASAL1 MAPK9 MAPK10 RASGRP1 REL MAP2K1 MAP2K2 PAK3 PRKCG NRAS PAK5 RASA4B PAK2 NGFR PLA2G12B RASGRP3 PLCG1 NF1 PLCG2 PLA2G4C PRKCA KSR1 PLD1 PRKCB PLA2G16 STK4 PAK4 PLD2 GRIN2B GRIN2A LAT GRIN1 TEK MAPK1 MAPK3 PLA2G2C RASAL3 RAP1A EXOC2 CHUK RAP1B ETS2 ETS1 RGL2 AKT1 PLA2G3 SHC3 AKT2 TTBK1 RALGDS RAB5A KRAS RAB5B NFKB1 RAC2 RAC3 BAD CSF1R GNG2 GRB2 GNB4 ELK1 MRAS AFDN MAPK8 ZAP70 RASA4 FOXO4 PIK3R3 RAB5C RAC1 EGFR CALML4 SHC1 CALML6 RAF1 RIN1 GNB1 FGFR4 FGFR2 FGFR3 FGFR1 RASGRP4 RASA3 PLA2G4E PLCE1 GNB5 IKBKG GAB2 RASA1 EPHA2 RASA2 RASGRF1 BUB1B-PAK6 RASGRF2 PAK6 Regucalcin in proximal tubule epithelial kidney cells WP4838 TGFBR1 RGN PTH TGFB1 FFAR3 BRAF CALCA BAK1 PPP3R1 APAF1 NOS1 CASP3 TNFRSF1A MCU PDE1B SMAD2 MAPK1 TNFSF11 ACTA2 RELA SMAD4 RAF1 PIK3CA BAX TRPV5 CASP8 CASP9 MTOR PRKCQ SEC16B AKT1 MAP3K5 G3BP1 Regulation of Actin Cytoskeleton WP51 ARPC5 FGF22 F2R F2 CDC42 BRK1 RRAS2 PDGFA ROCK2 PDGFB WAS PDGFRA MOS CFL2 CFL1 GNG12 PXN RRAS PIP4K2A FGF18 NCKAP1 FGF20 WASF1 CD14 PIP4K2B PIK3C2A PIK3C2B PIK3C2G PIK3C3 SOS1 PIP5K1A PIP5K1B ROCK1 MYH10 ENAH PDGFRB FGF17 FGF16 PIP4K2C IQGAP1 PIK3CG PIK3R1 PIK3R2 RASSF7 TMSB4X PAK1 ITGA1 ARHGEF1 CHRM4 CHRM3 GIT1 PIK3CA PIK3CB PIK3CD CHRM2 CHRM1 RHOA DIAPH3 FN1 PIP5K1C RDX SOS2 MYL1 MSN MYL3 MAP2K1 MAP2K2 MYLK PAK3 NRAS ARHGAP35 PAK5 PAK2 CYFIP2 BAIAP2 BRAF SSH1 CHRM5 APC2 PFN1 SLC9A1 PAK4 MAPK1 MAPK3 PIK3R4 MAPK4 MAPK6 PIK3R5 APC SSH3 ACTB PTK2 PPP1R12A KRAS VAV1 BCAR1 ARHGEF4 RAC2 RAC3 FGF19 ABI2 ARHGEF7 FGF9 FGF8 FGF7 FGF6 FGF5 FGF23 GNA12 FGF4 FGF3 EGF FGF2 FGF1 FGD1 CRK DOCK1 MRAS VCL PIK3R3 ACTG1 GNA13 RAC1 EGFR FGF21 PIP5KL1 EZR ARHGEF6 WASF2 RAF1 FGFR4 FGFR2 FGFR3 FGFR1 FGF14 CSK FGF13 FGF12 FGF11 FGF10 BDKRB1 BDKRB2 LIMK1 DIAPH1 SSH2 VIL1 BUB1B-PAK6 PAK6 GSN ACTN1 Regulation of apoptosis by parathyroid hormone-related protein WP3872 PIK3CG ITGB4 BCL2L15 BCL2L14 BCL2L13 MCL1 BAX GSK3B BCL2 GSK3A MYC BCL2A1 BCL2L1 BCL2L2 BAK1 BOK AKT1 PTHLH BID BCL2L12 ITGA6 BCL2L10 Regulation of Microtubule Cytoskeleton WP2038 MAP1B TRIO F2RL2 MAPKAPK2 DVL1 CDC42 PRKCA TPPP CLASP1 TAOK1 CFL2 STMN1 APC PTPRA MAPT AKT1 MAPRE1 TESK2 MARK1 SRC RHO ABL1 PHLDB2 STAT3 MARK2 ROCK1 EPHB2 CLIP1 CAMK4 PARD6A RAC1 KIF2C AURKB WNT3A SPRED1 PAK1 PIK3CA TIAM1 PTEN GSK3B GNAQ CDK1 PRKACA DPYSL2 LIMK1 DIAPH1 Regulation of sister chromatid separation at the metaphase-anaphase transition WP4240 MAD2L1 ANAPC11 PTTG1 SMC1A ESPL1 SMC3 MAD1L1 CENPE BUB3 ANAPC2 CDC20 BUB1 BUB1B RAD21 STAG1 Regulation of toll-like receptor signaling pathway WP1449 SOCS1 FADD CCL4 CCL5 TOLLIP RNF216 CCL3 PTPN6 ZMYND11 CD180 MAP3K7 TIFA SFTPA2 CUEDC2 LBP IRAK4 TMED7 MYD88 TRAF3 IKBKE CD14 CXCL11 TRAF6 TIRAP TLR5 RNF41 STAT1 IRF3 TRAFD1 TICAM1 SIGIRR PELI3 IRAK1 IRAK2 PIK3CG PIK3R1 PIK3R2 MAPK12 MLST8 RELA USP7 RNF31 IKBKB OTUD5 PIK3CA PIK3CB PIK3CD MAP2K6 MAP2K7 CD80 TLR8 CD86 AKT3 IRF5 MAPK11 IRF7 MAP2K4 MAPK9 MAPK10 MAPK13 IRAK3 MAP2K1 MAP2K2 MAP2K3 TNF IFNA5 FOS IFNA4 IFNA2 LY96 SMAD6 IFNA1 TLR7 RBCK1 IL1B CD40 TLR6 TAB1 CTNNAL1 TLR4 TLR3 SFTPD MAPK1 MAPK3 TICAM2 CISH IFNA21 IFNA17 PIK3R5 TLR2 TLR1 IFNA16 TBK1 IFNA14 IL6 IFNA13 IFNA10 CHUK IFNA8 CASP8 IFNA7 SARM1 CYLD IFNA6 PLK1 TNFAIP3 RIPK1 AKT1 AKT2 JUN NFKB1 MBL2 NFKB2 NFKBIA SYK SPP1 PELI2 PELI1 TREM1 BTK MAPK14 IFNB1 CXCL8 IFNAR2 IFNAR1 MAPK8 PIK3R3 RAC1 CXCL9 IL12B TAB3 IL12A TAB2 MAP3K8 FBXW5 IKBKG TLR9 SQSTM1 CXCL10 Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds WP3664 FZD1 FZD8 AXIN1 LRP1 FZD7 WNT1 GSK3B CTNNB1 LEF1 APC DKK3 CSNK1A1 SFRP4 TNKS MBOAT1 DVL2 TCF4 Regulatory circuits of the STAT3 signaling pathway WP4538 IL27RA IL3RA MAPK15 DEPTOR OSMR IL2RG IL2RB SOCS3 F2RL2 IL2RA JAK1 JAK2 F2R JAK3 PRKCB TYK2 MAPK1 MAPK3 PDGFRA IFNLR1 MAPK4 MAPK6 MAPK7 IL6ST IL6R CNTFR STMN1 IL15RA IL5RA CREBBP MTOR IL20RB PTPRC IL20RA PTPRD SRC F2RL3 MPL STAT3 RICTOR GHR IFNGR2 IL9R IFNGR1 MAPK14 RPTOR IFNAR2 IFNAR1 IL7R PDGFRB MAPK8 PTPRT TRIM28 CSF2RB EGFR LIFR IL21R CSF2RA MAPK12 MLST8 IL12RB2 AGTR1 IL11RA AGTR2 DUSP2 CTF1 SETD7 AKT1S1 IL10RB IL10RA IL22RA1 CSF3R MAPKAP1 MAPK11 MAPK9 MAPK10 MAPK13 PIAS3 Relationship between inflammation, COX-2 and EGFR WP4483 NRAS ESR1 HRAS BRAF PLA1A PTGER1 PTGER2 PTGER3 PTGER4 PTGES2 EGFR PIK3CG MAPK1 MAPK3 PIK3CA PIK3CB PIK3CD CYP19A1 AKT3 MMP1 AKT1 PTGS2 AKT2 SRC KRAS Renin-angiotensin-aldosterone system (RAAS) WP4756 CALM3 CREB5 STAR CYP11A1 CREB1 HSD3B2 HSD3B1 CMA1 CTSG CALML3 ITPR3 CAMK4 CAMK2A CAMK2B CAMK2D ACE CAMK2G CALML4 CALML5 PLCB2 CREB3L1 CALML6 CREB3L2 REN AGT AGTR1 CAMK1G AGTR2 CAMK1D CYP21A2 GNAQ ITPR1 ATF1 ITPR2 ATF6B CYP11B2 ATF4 ATF2 CREB3L4 CREB3L3 CALM1 CAMK1 CREB3 CALM2 Resistin as a regulator of inflammation WP4481 NFKB1 NFKBIA TNF MAPK14 CXCL8 PLCG1 PLCG2 PIK3CG MAPK1 PLCB2 MAPK3 PLCB3 PLCB4 RELA PLCD1 PLCD3 IKBKB IL12B PIK3CA PLCB1 IL12A PIK3CB PIK3CD PLCD4 IL6 PLCE1 CHUK ITPR1 AKT3 AKT1 IKBKG RETN AKT2 Retinoblastoma gene in cancer WP2446 MCM3 MCM4 SMARCA2 MCM6 MCM7 HLTF POLA1 RFC3 CDK6 KIF4A SIN3A CDK4 PLK4 CCND1 CDK2 CDC25A MYC CDC25B FANCG SKP2 RBBP7 RRM2 PRKDC RRM1 TYMS PCNA SUV39H1 STMN1 SAP30 CDKN1B DNMT1 CDKN1A ANLN RPA1 RFC4 RFC5 RPA3 POLE RPA2 POLE2 E2F1 MSH6 RBP1 ABL1 WEE1 SMC2 SMC3 TFDP1 HDAC1 MDM2 CCDC6 CCNA2 CCNB1 POLD3 DCK CCND3 H2AFZ E2F3 CCNE1 CHEK1 E2F2 NPAT DHFR FAF1 PRIM1 RABIF TOP2A CCNB2 CCNE2 SMC1A TP53 RAF1 PRMT2 BARD1 TTK RBBP4 ZNF655 CDK1 HMGB2 CDT1 HMGB1 CDC45 TFDP2 CDC7 ORC1 MAPK13 RB1 Rett syndrome causing genes WP4312 SMARCA2 EIF2B2 CDKL5 SMARCA1 SMARCA4 TRRAP SRRM3 BRAF TBL1X CECR2 MECP2 GRIN2B HDAC5 GRIN2A MEF2C SCN1A HIVEP2 GABRA3 GPS2 ACTL6B XAB2 KCNJ10 CHD4 FOXG1 HAP1 GABBR2 SYNGAP1 SCN8A RHOBTB2 SYNE2 HDAC1 HTT IMPDH2 CRK GABRD SHANK3 SCN2A HDAC8 TBL1XR1 TCF4 TAF1B SMC1A NCOR2 NCOR1 SATB2 GNAO1 STXBP1 KDM5B Riboflavin and CoQ disorders WP5037 FLAD1 ETFDH SLC52A1 SLC52A2 ETFA COQ9 COQ8A PDSS2 PDSS1 COQ7 COQ2 APTX RFK COQ6 Robo4 and VEGF Signaling Pathways Crosstalk WP3943 SLIT2 KDR VEGFA ROBO4 RAC1 SRC Role of Altered Glycolysation of MUC1 in Tumour Microenvironment WP4480 IL6 NFKB1 MUC1 CHUK NFKBIA TNF RELA IKBKG IKBKB Role of Osx and miRNAs in tooth development WP3971 SP7 HNF1A CTNNB1 BMP7 DMP1 DSPP DKK1 KLF4 RUNX2 ALPL NOTCH1 NOTCH2 NOTCH3 NOTCH4 SOST SARS coronavirus and innate immunity WP4912 IKBKE TRAF3 STAT2 IFIH1 STAT1 IRF3 IFNA5 IFNA4 IFNA2 DDX58 TICAM1 IFNA1 JAK1 IFNB1 IFNAR2 IFNAR1 MAVS IRF9 TYK2 TLR3 IFNA21 IFNA17 ACE2 IFNA16 IFNA14 TBK1 IFNA13 IFNA10 IFNA8 IFNA7 IFNA6 SARS-CoV-2 altering angiogenesis via NRP1 WP5065 FURIN KDR VEGFA ACE2 NRP1 SARS-CoV-2 and angiotensin-converting enzyme 2 receptor: molecular mechanisms WP4883 MAS1 TMPRSS2 REN AGT ACE2 AGTR1 ACE SARS-CoV-2 and COVID-19 Pathway WP4846 CTSL TLR7 FURIN ACAT1 TMPRSS2 SLC6A19 ACE2 NRP1 SCARB1 TMPRSS4 SARS-CoV-2 innate immunity evasion and cell-specific immune response WP5039 FADD CCL4 TP53I3 CCL5 TNF EP300 LARP1 TGFB1 DHX58 JAK1 TLR7 NUP98 IFIT2 CCL3 CCL2 TANK MAVS PF4 PPBP IL6R AP1G1 BSG IL6 TBK1 CASP8 CXCL1 RIPK1 CXCL11 TRAF3 CXCL6 TRAF2 TRAF6 NFKB1 CXCL5 TRAF5 STAT2 STAT1 IRF3 HDAC2 DDX58 TFAP2A CSF2 CXCL3 CXCL2 CXCR2 HAVCR2 IFNB1 CXCL8 IFNAR2 IFNAR1 CD160 CXCL9 SMAD3 CXCL12 ACE2 RAE1 LAG3 IL10 MX1 CXCL13 IRF7 CXCL17 CXCL10 TRIM25 TRADD IFITM1 SARS-CoV-2 mitochondrial interactions WP5038 IKBKE TRAF3 NFKB1 TRAF6 NFKB2 IFIH1 IRF3 PHB ACAD9 DDX58 NLRX1 TICAM1 CTSL TLR7 CGAS NDUFAF1 BCS1L MAVS ACE TLR3 TMPRSS2 TMEM173 ACE2 AGTR1 AGTR2 TBK1 ECSIT NOX1 PHB2 IRF7 TOMM70 NDUFB9 SCFA and skeletal muscle substrate metabolism WP4030 FFAR2 FFAR3 GCG PYY PPARD SLC2A4 Secretion of Hydrochloric Acid in Parietal Cells WP2597 ATP4A CHRM1 GAST CCKBR HRH2 Selective expression of chemokine receptors during T-cell polarization WP4494 CCL4 TGFB3 TGFB1 IFNGR2 TGFB2 CSF2 IL2 IFNGR1 CCR7 IFNG IL18R1 CCR5 CCR4 CCR3 CCL3 CD40LG CCR2 CXCR4 IL12RB2 CCR1 IL12RB1 IL12B IL12A CXCR3 IL5 CD28 IL4R IL4 CD4 Selenium Micronutrient Network WP15 PLG PRDX2 TNF F7 HBB PNPO PRDX5 DIO2 DIO1 SELENOK HBA1 F2 LOC102724197 PRDX3 CBS TXNRD3 IL1B FGG INS CCL2 MTHFR DIO3 TXNRD1 SERPINA3 SELENON SAA2 XDH SAA1 KYNU SEPHS2 FGA ABCA1 FLAD1 ALOX5 TXN ALOX5AP GPX3 GPX2 GGT1 PRDX4 GPX1 IL6 ALOX15B GPX6 PTGS1 PTGS2 INSR CAT TXNRD2 MSRB1 GPX4 SELENOM NFKB1 NFKB2 SELENOF MPO ICAM1 SAA4 GGTLC1 SELENOH IFNG ALB APOA1 FGB APOB SOD1 SOD3 SELENOS MTR SOD2 PRDX1 KMO GGT2 SELENOV SERPINE1 RELA GGTLC2 CTH LDLR CRP SELENOO RFK SELENOP SELENOI PLAT SELENOW GSR SCARB1 SELENOT Senescence and Autophagy in Cancer WP615 KMT2A IGFBP3 TGFB1 IGF1R BCL2 LAMP1 CDC25B IGF1 RSL1D1 CCL3 MMP14 INS GABARAPL2 CREG1 ULK1 ATG7 THBS1 ATG5 ATG16L1 IGFBP7 MAP1LC3A IGFBP5 VTN BMI1 LAMP2 E2F1 BECN1 PIK3C3 HRAS MDM2 BMP2 MAP1LC3B AMBRA1 IRF1 SERPINE1 SERPINB2 SMAD3 MLST8 SMAD4 ATG13 IL1A GABARAPL1 ATG14 PTEN SLC39A4 IFI16 AKT1S1 FN1 IRF5 IRF7 PLAT PLAU MAP2K1 GABARAP MAP2K3 MAP1LC3C RB1CC1 CXCL14 IL3 SLC39A2 ATG12 BRAF SLC39A3 HMGA1 IL1B MAPK1 PCNA IL6ST IL6R RNASEL CDKN2A IL6 SLC39A1 CDKN1B CD44 CDKN1A COL10A1 MTOR FKBP8 CXCL1 SPARC UVRAG SRC JUN COL3A1 IL24 ATG10 IFNG SH3GLB1 IFNB1 MAPK14 CXCL8 COL1A1 TP53 RAF1 ATG3 CEBPB GSK3B INHBA ING2 ING1 TNFSF15 SQSTM1 GSN RB1 Serine Metabolism WP4688 SHMT2 TYMS DHFR PHGDH PSPH SHMT1 SRR PSAT1 Serotonin and anxiety WP3947 TRPV1 PLEK PPP3CA POMC FOS CRH HTR1A ARC PLCD4 GRM1 HTR2C GABRA1 ADRA1A HTR2A FMR1 PRKCB CAMK2B Serotonin and anxiety-related events WP3944 PLEK PPP3CA FOS NLGN1 CRHR1 HTR1A CRH ARC PLCD4 HTR2C HTR2A PRKCB GRIN2D Serotonin Receptor 2 and ELK-SRF/GATA4 signaling WP732 MAPK1 MAPK3 RAF1 NRAS HRAS MAPKAPK2 GNAQ HTR2C ITPR1 ELK4 HTR2B HTR2A ELK1 SRF RASGRP1 RASGRF1 MAP2K1 MAP2K2 KRAS GATA4 Serotonin Receptor 4/6/7 and NR3C Signaling WP734 MAPK1 MAPK3 CREB1 HTR7 HTR6 RPS6KA5 HTR4 MAPKAPK2 GNAS RAP1A BRAF ATF1 ELK4 ELK1 SRF NR3C1 EGR1 MAP2K1 MAP2K2 Serotonin Transporter Activity WP1455 ITGB3 TPH2 IL1R1 SLC6A4 IL1B SCAMP2 NOS1 MAOA PPP2CB TGFB1I1 STX1A Signal Transduction of S1P Receptor WP26 PIK3C2B SMPD2 GNAI2 GNAI1 RACGAP1 PLCB2 MAPK1 PLCB3 MAPK3 MAPK12 MAPK4 MAPK6 MAPK7 PLCB1 S1PR2 GNAI3 AKT3 ASAH1 AKT1 SPHK1 AKT2 S1PR3 S1PR1 S1PR5 SPHK2 Signal transduction through IL1R WP4496 TGFB3 NFKB1 TRAF6 NFKBIA TNF TGFB1 TGFB2 MAP3K14 IFNA1 TOLLIP IL1RN IL1RAP IFNB1 MAPK14 IL1R1 IL1B MAPK8 IRAK1 IRAK2 TAB1 RELA MAP3K7 IL1A IKBKB MAP2K6 IL6 ECSIT CHUK MAP3K1 IRAK3 MYD88 MAP2K3 JUN Signaling of Hepatocyte Growth Factor Receptor WP313 HGF PTPN11 MAP4K1 MET SOS1 STAT3 FOS HRAS RAPGEF1 GRB2 CRKL CRK ELK1 DOCK1 MAPK8 GAB1 MAPK1 MAPK3 PAK1 RAF1 ITGA1 PTK2B PIK3CA PTEN PXN RAP1A RAP1B RASA1 ITGB1 SRC PTK2 MAP2K1 MAP2K2 JUN Simplified Depiction of MYD88 Distinct Input-Output Pathway WP3877 TLR4 TRAF6 NFKB1 TLR5 UBE2N TIFA UBE2V1 IL1A TLR2 TLR1 TLR7 TLR10 TLR8 IRAK1 TLR9 TLR6 MYD88 JUN Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway WP3670 LOXL4 NFE2L2 CDC37 PKD1 FGF7 SIRT1 TGFB1 COL2A1 DDR1 IGFBP7 BMP2 SUV39H1 ECSIT FN1 EXOC6 NQO1 ANXA5 NRF1 Sleep regulation WP3591 OXT GHRL OXTR STAR FOS AHCY CHRNB2 NLGN1 GHRH SLC29A1 HCRTR2 HCRTR1 ADORA1 ADORA2A UTS2 HTR2A NPAS2 MTNR1B NPY2R DRD3 GRIN2A DLAT DRD2 DRD1 TH NPS PTGDS PER3 CST3 CRH ADA PTGDR IL6 BTBD9 CACNA1I MRGPRX2 UTS2R IL18 Small cell lung cancer WP4658 FHIT LAMB2 CCND1 LAMB3 BCL2 LAMC1 MYC BCL2L1 LAMA1 LAMC2 BID NOS2 LAMA4 LAMA5 TRAF4 LAMB1 E2F1 GADD45B TRAF3 TRAF2 TRAF6 TRAF5 RXRA RXRG RXRB TRAF1 GADD45G E2F3 CCNE1 E2F2 ITGA6 POLK PIK3R1 PIK3R2 CCNE2 RELA ITGA2 IKBKB PIK3CA PIK3CB PIK3CD PTEN DDB2 FN1 AKT3 GADD45A BIRC8 CDK6 LAMB4 CDK4 CDK2 ITGA2B APAF1 ITGA3 CASP3 CDKN2B CDKN1C CDKN1B BIRC7 CDKN1A CHUK CASP8 CASP9 ITGAV AKT1 PTGS2 AKT2 BIRC2 CYCS ITGB1 PTK2 NFKB1 NFKBIA NFKBIB COL4A4 CKS2 COL4A3 CKS1B COL4A2 COL4A1 RARB BIRC3 LAMC3 BAK1 MAX PIK3R3 TP53 SKP1 BAX ZBTB17 LAMA2 COL4A6 LAMA3 COL4A5 IKBKG RB1 Small Ligand GPCRs WP247 S1PR4 GPR50 S1PR2 PTGIR PTGDR CNR2 CNR1 MTNR1A PTGER1 PTGER2 MTNR1B PTGER3 PTGER4 S1PR3 PTAFR LPAR1 S1PR1 PTGFR TBXA2R Somatic sex determination WP4814 SOX9 PTGDS FGF9 WNT4 WT1 AMH DMRT1 FOXL2 RSPO1 SOX8 SRY DHH GATA4 NR5A1 Somatroph axis (GH) and its relationship to dietary restriction and aging WP4186 PTEN MTOR AKT1 SIRT1 FOXO1 IGF1R Somitogenesis in the context of spondylocostal dysostosis WP4785 MESP2 RIPPLY2 HES7 DLL1 NOTCH1 TBX6 EPHA4 DLL3 LFNG Sphingolipid Metabolism (general overview) WP4725 SGMS2 CERK SGPP2 UGCG UGT8 CERS2 DEGS2 CERS3 SGPP1 DEGS1 SGMS1 SPTLC1 SMPD1 GDF1 CERS6 CERS1 KDSR CERS4 SGPL1 SPTLC2 ASAH1 SPHK1 PLPP3 SPHK2 Sphingolipid Metabolism (integrated pathway) WP4726 SGMS2 CERS5 UGT8 SPTLC1 SMPD1 CERS1 SPTLC2 CERK SGPP2 UGCG CERS2 DEGS2 CERS3 SGPP1 DEGS1 SGMS1 GDF1 CERS6 KDSR CERS4 SGPL1 ASAH1 SPHK1 PLPP3 SPHK2 Sphingolipid pathway WP1422 SGMS2 CERS5 PLPP1 UGT8 ACER1 SPTLC1 SPTLC3 SPTLC2 PPP2CA GBA GBA2 B4GALT6 CERK SGPP2 GAL3ST1 PPP1CA UGCG CERS2 CERS3 SGMS1 SERINC1 ASAH2 CERS6 CERS4 KDSR SGPL1 COL4A3BP ASAH1 SPHK1 SPHK2 Spinal Cord Injury WP2431 FCGR2C PRB1 VCAN GFAP TGFB1 LTB AIF1 CCND1 GDNF MYC AQP1 CDC42 BTG2 CCL2 NOS1 NOS2 TACR1 FOXO3 SLIT2 ROCK2 CCR2 EPHA4 AQP4 FKBP1A CSPG4 NCAN PTPRA OMG E2F1 PLA2G6 ROS1 PLA2G2A PLA2G5 LTB4R ICAM1 E2F5 SELP KLK8 PDYN SOX9 IL1A ARG1 RGMA RHOA RHOB ANXA1 RHOC GJA1 FCGR2A GADD45A NOX4 MAG TNF NTN1 FOS RTN4 NR4A1 NGFR CDK4 LGALS3 CDK2 IL2 IL1R1 IL1B C1QB PRKCA LILRB3 LEP CASP3 GRIN1 CHST11 TLR4 MAPK1 MAPK3 TNFSF13 BCAN SEMA6A IL6 CDKN1B CD47 IL4 LOC102725035 GAP43 CXCL1 APEX1 PTGS2 EFNB2 C5 XYLT1 PLXNA2 MBP COL4A1 COL2A1 ACAN CXCL2 IFNG CXCL8 TNFSF13B ZFP36 EGR1 RAC1 EGFR MIF VIM RTN4R SLIT3 SLIT1 TP53 PPP3CA MMP12 CDK1 CCNG1 LILRB2 BDNF PTPRZ1 MMP9 CXCL10 RB1 Splicing factor NOVA regulated synaptic proteins WP4148 CASK CADM1 GABBR2 SNW1 MAP4 CDH2 STX2 ATP2B1 NTNG1 GABRG2 APLP2 CADM3 CAV2 CHL1 GRIN2B KCNMA1 GRIN1 CAMK2G MAPK4 PLCB4 CLASP1 CLSTN1 EPB41L3 PRKCZ CSN3 TERF2IP DAB1 ANK3 GRIK2 EPB41L2 RAP1GAP EPB41L1 NCDN EPB41 KCNJ6 KCNQ2 AGRN MAPK9 GPHN NEO1 STXBP2 EFNA5 SREBF and miR33 in cholesterol and lipid homeostasis WP2011 NR1H3 PRKAA1 SREBF1 PPARA HMGCR ABCA1 SIRT1 FASN LDLR MED15 MTOR HMGCS1 PPARGC1A SREBF2 SIRT6 SCD SRF and miRs in Smooth Muscle Differentiation and Proliferation WP1991 KLF4 NKX2-5 MEF2B CCND2 ELK1 SRF MYOCD MEF2A CAMK2D MEF2C MEF2D Statin inhibition of cholesterol production WP430 PLTP DGAT1 LRP1 CYP7A1 PDIA2 APOA1 APOA2 APOA4 FDFT1 APOB SOAT1 LCAT MTTP ABCG8 ABCG5 LPL LIPC ABCA1 HMGCR APOA5 CETP APOC1 APOC2 LDLR APOC3 ACSS1 APOE SQLE SCARB1 Steroid Biosynthesis WP496 CPN1 CYP17A1 HSD17B7 F13B HSD17B4 HSD3B2 HSD3B1 HSD17B2 HSD17B3 HSD17B1 Sterol regulatory element-binding proteins (SREBP) signaling WP1982 SEC13 ACLY CREB1 SEC31A FASN INSIG1 MBTPS2 KPNB1 FDPS HMGCS1 FDFT1 INS SP1 SAR1B NFYA NR1H2 SEC24D ATF6 LPL SREBF1 SEC24C RBP4 SIRT1 SEC31B GPAM DBI SEC24B PRKAG3 CDK8 LPIN1 MTOR AKT1 PPARG SQLE RNF139 SCD YY1 PPARGC1B PRKAA1 SCAP PRKAA2 PRKAB1 PRKAB2 MVD MDH1 INSIG2 MED15 CYP51A1 PRKAG2 SREBF2 ACACA FGF21 PRKAG1 MBTPS1 LSS HMGCR SAR1A PIK3CA GSK3A SEC24A AMFR LDLR ACSS1 CAMP IDI1 PRKACA SEC23A SEC23B SCARB1 STING pathway in Kawasaki-like disease and COVID-19 WP4961 IKBKE FCGR2C NFKB1 NFKBIA RELA TMEM173 IRF3 NFKBIE IKBKB F3 NLRP3 GSDMD NLRX1 TBK1 CHUK ITPR1 IFNB1 FCGR2A IL1B CGAS IKBKG REL Striated Muscle Contraction Pathway WP383 ACTN2 ACTN3 TPM2 TNNC2 TCAP TPM1 TNNT3 MYBPC2 DMD MYBPC3 DES ACTC1 MYH3 TNNT2 ACTG1 MYL9 MYH6 MYBPC1 NEB MYH8 TNNC1 VIM ACTA1 TMOD1 ACTA2 TNNI2 TNNI1 TNNT1 TNNI3 TPM3 TPM4 TTN MYOM1 ACTN4 MYL1 MYL2 MYL3 MYL4 Structural Pathway of Interleukin 1 (IL-1) WP2637 FOS MAPKAPK2 MAP3K14 TOLLIP MYC IL1RAP IL1R1 TANK MKNK1 TAB1 EIF4E MAPK1 MAPK3 MAP3K7 CHUK IRAK4 MKNK2 ATF2 MAP3K1 MAP3K3 MYD88 TRAF6 NFKB1 NFKBIA MBP NFKBIB SAFB MAPK14 ELK1 MAPK8 IRAK1 IRAK2 RELA IL1A IKBKB TAB3 RPS6KA5 TAB2 MAP3K8 MAP2K6 MAP2K7 MAPK11 IRF7 MAP2K4 MAPK9 MAPK10 MAP2K1 MAP2K2 MAP2K3 Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways WP706 TPH1 SSTR1 SST SSTR2 EP300 TP73 FOXM1 PHOX2B HTR3A ATP1A3 ADCYAP1 HTR2A TPH2 GNB3 ADCYAP1R1 PPARGC1A MECP2 TACR1 MYB MEF2C KCNH2 SLC1A3 TH HIF1A SNTA1 TPPP AQP4 TLX3 GPD1L AR CHAT PHOX2A GABRA1 NANOG KCNJ8 CTCF DLX2 BHLHE40 THRB SLC6A4 RORA HSP90B1 FMO3 YBX1 TCF3 PKNOX1 ACADM RYR2 PAH PRKAR1A POU2F2 NEUROD1 POU3F2 PRKAR1B PRKAR2A ESR2 CPT1A IL1A HADHB HADHA CHRM2 NTRK2 DDC GJA1 KCNQ1 PRKACA PRKACB ASCL1 SOX2 DEAF1 ECE1 HES1 SP3 POU5F1 LMX1B SLC9A3 TNF MAP2 LOC101929970 CREB1 CHRNB4 CHRNB2 GATA3 GATA2 AVP CHRNA7 CHRNA4 IL1RN CTNNB1 IL1B NR3C1 SP1 PRKAR2B MAOA CASP3 SCN3B NFYA REST YWHAQ RET GRIN1 NGF YWHAG PLP1 YWHAE YWHAZ TSPYL1 YWHAH HES5 IL6R CREM HSPD1 IL6 C4A C4B CREBBP GAPDH SPTBN1 CDCA7L YWHAB JUN MAZ PPARGC1B SCN5A NFKB1 PBX1 MBD1 SCN4B NFKB2 VEGFA NOS1AP SLC25A4 HDAC1 GCK CXCL8 CHRFAM7A TF NKX2-2 VAMP2 CAV3 EGR1 NKX3-1 FEV VIPR1 HDAC9 TAC1 VIPR2 IL13 HTR1A CEBPB EN1 ALDOA CC2D1A RUNX3 IL10 BDNF SNAP25 G6PC Sulfation Biotransformation Reaction WP692 SULT1E1 SULT6B1 LOC105369243 PAPSS1 PAPSS2 SULT4A1 SULT1A1 SULT1C3 SULT1C2 SULT1B1 SULT1A4 SULT1C4 SULT1A2 SULT2B1 SULT2A1 GSR G6PD Sulindac Metabolic Pathway WP2542 MSRB2 MSRA CYP1B1 CYP1A2 MSRB3 Supression of HMGB1 mediated inflammation by THBD WP4479 AGER NFKB1 THBD CHUK NFKBIA RELA HMGB1 IKBKB IKBKG Synaptic signaling pathways associated with autism spectrum disorder WP4539 RPS6KB1 TSC1 NRAS NF1 GRIN2D GRIN2C GRIN2B GRIN2A GRIN1 EIF4EBP1 MAPK1 MAPK3 GRM1 DLG4 GRIN3A PRKAG3 MTOR GRIN3B AKT1 TSC2 AKT2 KRAS PRKAA1 SYNGAP1 PRKAA2 PRKAB1 PRKAB2 HRAS CACNA1C RPTOR SHANK3 PRKAG2 UBE3A PIK3R3 RHEB CAMK4 CAMK2B PIK3R1 PRKAG1 PIK3R2 HOMER1 PIK3CA PIK3CB ARC PIK3CD PTEN GSK3B NTRK2 AKT3 BDNF Synaptic Vesicle Pathway WP2267 RIMS1 NAPA CPLX1 CLTC ATP1A2 CPLX2 CLTA UNC13B SLC32A1 DNM1L SLC1A3 STX1B SYN3 AP2A1 AP2A2 AP2B1 SLC17A7 DNM2 RAB3A CLTCL1 PARK7 SLC18A2 SLC18A1 SLC18A3 SLC6A4 CLN8 STX2 UNC13A SLC25A4 UNC13C SLC17A6 DNM3 STX3 NSF CACNA1A CACNA1B VAMP2 DNM1 STX1A SLC22A3 CPLX3 SLC17A8 AP2S1 AP2M1 SLC38A1 SYN2 SYN1 STXBP1 SYP SNAP25 SYT1 Synthesis and Degradation of Ketone Bodies WP311 ACAT1 HMGCS2 BDH1 HMGCL OXCT1 T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection WP3863 NCK1 CHP1 TNF NFATC2 FOS MAP3K14 CDK4 IL2 PLCG1 PTPN6 DLG1 MALT1 LAT CD3D CD40LG MAPK3 MAP3K7 IL5 CHUK CARD11 IL4 CD4 PRKCQ RRAS AKT1 CALM1 PTPRC CD8A CALM2 JUN PDK1 NFKB1 NFKBIA SOS1 GRAP2 CSF2 LCP2 IFNG GRB2 ZAP70 AHSA1 LCK PDCD1 RAF1 PAK1 IKBKB CTLA4 PIK3CA MAP3K8 GSK3B MAP2K7 FYN CD28 ICOS IL10 CBL IKBKG MAPK9 MAP2K1 MAP2K2 ITK BCL10 T-cell receptor (TCR) signaling pathway WP69 PRKCD NCK1 PTPN11 MAP4K1 NFATC1 NFATC2 CREB1 FOS TGFB1 MAP3K14 SH2B3 GATA3 FAS IL1B CDC42 PLCG1 VAV3 RIPK2 MALT1 CD3D LAT CD3E CD3G CD247 MAPK1 MAPK3 WAS MAP3K7 DBNL TNFRSF9 IL6 IL15RA CHUK CARD11 CD4 ATF2 PRKCQ CD83 AKT1 CD8A JUN VAV1 IL17A NFKB1 TRAF6 NFKBIA SOS1 SKAP1 GRAP2 IRF4 HRAS LCP2 GRB2 IL9 MAPK14 CRKL CCR5 CRK MAPK8 ZAP70 LCK OPRM1 PIK3R1 PIK3R2 VIM RELA SHC1 PAK1 RAF1 IL1A IKBKB PSTPIP1 PTK2B PDPK1 MAP3K8 FYN FYB1 ITPR1 CD28 ICOS CBL IKBKG MAPK9 CBLB GAB2 REL MAP2K1 MAP2K2 ITK BCL10 T-Cell Receptor and Co-stimulatory Signaling WP2583 PDK1 NFKB1 NFKBIA NFATC2 IL2 CSNK1A1 PLCG1 ZAP70 PRKCA PTPN6 DYRK1A LCK PDCD1 PPP3CA DYRK2 CTLA4 PTEN GSK3B GSK3A FYN CD28 AKT1 CALM1 RASA1 RASGRP1 CD8A CALM2 CD8B ITK Tamoxifen metabolism WP691 UGT2B7 SULT1E1 UGT2B15 CYP2E1 FMO3 CYP2C8 CYP2C19 SULT1A1 FMO1 CYP1B1 CYP3A5 CYP1A2 CYP2D6 CYP3A4 CYP1A1 UGT1A8 UGT1A10 UGT1A4 SULT2A1 CYP2A6 CYP2C9 Target Of Rapamycin (TOR) Signaling WP1471 RPS6KB1 PRKAA1 PRKAA2 PRKAB1 TSC1 PRKAB2 RICTOR ULK3 DDIT4L RPTOR PRR5L CDC42 RRAGA PRKCA PRKAG2 RHEB RAC1 ULK1 EIF4EBP1 PRKAG1 RRAGC MLST8 HMGCR FKBP1A DDIT4 AKT1S1 PRKAG3 IDI1 MTOR TSC2 PRR5 AKT1 MAPKAP1 RRAGD RRAGB ULK2 TCA Cycle (aka Krebs or citric acid cycle) WP78 SDHA IDH3B SDHC SDHB FH MDH2 SDHD DLST CS IDH3G SUCLG1 SUCLA2 SUCLG2 ACO2 DLD IDH3A OGDH IDH2 TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) WP2453 ACLY ACO1 SDHA PC MDH1 FH PDHA1 IDH1 DLST CS PCK1 SUCLG2 DLD DLAT OGDH IDH3A TCA cycle in senescence WP5050 PDP2 PDK1 BRAF TP53 ME1 ME2 MDH1 GOT1 FH PDHA1 TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer WP2868 JAK1 MAPK1 MAPK3 STAT3 EGFR TFs regulate miRNAs related to cardiac hypertrophy WP1559 MYEF2 NFKB1 STAT3 AKT1 PPP3R1 AKT2 TGFB1 RASGRF1 TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition WP3859 VIM MAPK1 SMAD2 MAPK3 SMAD3 SMAD4 CDH2 ID1 TGFB1 TNC SNAI2 RUNX2 FN1 CDH6 CDH16 CDH1 AKT1 SNAI1 TGF-beta receptor signaling in skeletal dysplasias WP4816 LEFTY2 LTBP1 TGFBR1 LTBP3 TGFBR2 TNF TGFBR3 FOS EP300 SMAD5 TGFB1 SMAD6 SMAD7 SMAD9 JAK1 CTNNB1 FOXH1 THBS1 MAPK3 ITGB6 TGIF1 FKBP1A LEF1 CREBBP FST ZNF423 JUN NFKB1 BAMBI SPP1 SKIL SKI STAT1 STAT3 HRAS NOG LEFTY1 BMP4 IFNG EGF ADAMTS10 FBN1 ADAMTSL2 LIF ZEB2 SMAD1 SERPINE1 SMAD2 SMAD3 SMAD4 ENG WNT1 ZFYVE9 TFE3 RUNX2 INHBA RUNX3 MAPK9 TGF-beta Receptor Signaling WP560 LEFTY2 LTBP1 TGFBR1 TGFBR2 TNF TGFBR3 FOS EP300 SMAD5 TGFB1 SMAD6 SMAD7 SMAD9 JAK1 CTNNB1 FOXH1 THBS1 MAPK3 ITGB6 TGIF1 FKBP1A LEF1 CREBBP FST ZNF423 JUN NFKB1 BAMBI SPP1 SKIL SKI STAT1 STAT3 HRAS NOG LEFTY1 BMP4 IFNG EGF LIF ZEB2 SMAD1 SERPINE1 SMAD2 SMAD3 SMAD4 ENG WNT1 ZFYVE9 TFE3 RUNX2 INHBA RUNX3 MAPK9 TGF-beta Signaling Pathway WP366 TGFBR1 TGFBR2 MAP4K1 TGFBR3 EP300 TGFB1 PIAS2 NEDD4L APP TGFB1I1 CCND1 MYC CDC42 TRAP1 MEF2A RBX1 RBL1 FOXH1 RBL2 MEF2C YAP1 THBS1 MAP3K7 TGIF1 ITCH NUP214 TNC NEDD9 UCHL5 UBE2I SUMO1 PDK1 TRAF6 SKIL SKI AXIN1 SOS1 MET PIAS1 ZFYVE16 PJA1 ROCK1 E2F5 E2F4 BTRC RNF111 PARD6A PIK3R1 STRAP CCNB2 PIK3R2 SMAD2 SMAD3 SMAD4 PRKAR2A ITGA2 EID2 KLF10 ZFYVE9 MAP2K6 RHOA FN1 MAPK9 MAP2K4 ZEB1 WWP1 MAP2K1 MAP2K2 MAP2K3 HGS CUL1 SMURF2 FOS SMAD7 SIN3A PAK2 SP1 DCP1A TAB1 SIK1 KLF11 ITGB3 MAPK1 ITGB4 TERT MAPK4 SMURF1 CDKN2B JUNB COPS5 JUND STAMBPL1 CDKN1A ETS1 CREBBP ATF2 FOSB SPTBN1 AKT1 ITGB1 SRC PTK2 JUN BCAR1 SNW1 TFDP1 HDAC1 KLF6 SNIP1 GRB2 MAPK14 COL1A2 MAPK8 CAV1 RAC1 ZEB2 PML NUP153 PPM1A SHC1 TP53 SKP1 RAF1 MMP12 DAB2 RUNX2 CDK1 ATF3 MMP1 CITED1 LIMK2 FOXP3 Tgif disruption of Shh signaling WP3674 FOXG1 NODAL TGIF2 SMAD2 SHH NKX2-1 FGF8 TGIF1 GLI3 The alternative pathway of fetal androgen synthesis WP4524 AKR1C2 HSD17B6 STAR CYP17A1 CYP11A1 POR HSD3B2 CYB5A HSD17B3 AKR1C4 SRD5A2 The influence of laminopathies on Wnt signaling WP4844 DICER1 TLE1 HES1 SPP1 AXIN1 TARBP2 ICMT CDK6 CSNK1A1L HMGA2 EMD WNT10B CCND1 TCF7L1 CTNNB1 CSNK1A1 TOR1AIP1 AGO2 LMNA SREBF1 ADIPOQ HES5 CEBPD CEBPB CEBPA FNTA GSK3B RUNX2 APC LEF1 PPARG TCF7 SLC2A4 TCF7L2 ZMPSTE24 The Overlap Between Signal Transduction Pathways that Contribute to a Range of LMNA Laminopathies WP4879 TLE1 HES1 DICER1 KAT2B CSNK1A1L HMGA2 TGFB1 WNT10B TGFB2 CDK4 TCF7L1 CTNNB1 CSNK1A1 MAOA MAOB AGO2 SREBF1 TNFRSF11B HES5 JUNB CDKN1A APC LEF1 CREBBP NOTCH1 PPARG MYOD1 ACTB E2F1 ZMPSTE24 SPP1 AXIN1 NAP1L1 TARBP2 ICMT EMD HDAC1 BMP2 CTSK TMPO SMAD2 LMNA SMAD3 WNT7B MSTN CEBPD CEBPB CEBPA FNTA GSK3B RUNX2 LEMD3 TCF7 TCF7L2 RB1 Thermogenesis WP4321 RPS6KA3 CREB5 RPS6KA2 RPS6KB2 SMARCA2 RPS6KB1 SMARCA4 SMARCC1 SMARCB1 RPS6KA1 RPS6 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 PNPLA2 PPARGC1A MGLL FRS2 ACTL6B MAP3K5 PRKAA1 PRKAA2 SOS1 PRKAB1 PRKAB2 HRAS KDM1A BMP8A ACSL6 KDM3B RPTOR BMP8B PRKAG2 RHEB SIRT6 ACSL5 ACSL1 ARID1A PRKAG1 MLST8 MAPK12 NPR1 CPT1A UCP1 ACSL4 ARID1B ACSL3 AKT1S1 SLC25A20 CREB3L3 PRKACA SOS2 PRKACB MAPK11 PRKACG CREB3 MAPK13 MAP2K3 TSC1 NRAS CREB1 ADRB3 CPT1C CPT2 CPT1B ZNF516 PRKG1 PRKG2 CREB3L1 CREB3L2 SLC25A29 RPS6KA6 CNR1 PRKAG3 ATF2 MTOR CREB3L4 PLIN1 PPARG TSC2 ACTB ADCY10 KDM3A KRAS ADCY4 DPF3 DPF1 GRB2 MAPK14 GCG KLB SMARCC2 SMARCD2 ACTG1 SMARCD1 SMARCE1 SMARCD3 FGF21 LIPE PRDM16 FGFR1 GNAS ADCY1 ADCY2 ADCY3 ACTL6A Thiamine metabolic pathways WP4297 TPK1 BCKDK SLC19A3 SLC25A19 SLC19A2 TKT PDHA1 OGDH BCKDHA Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway WP2203 NFKB1 PTPN11 NFKB2 NFKBIA STAT1 STAT4 TEC STAT3 CCL11 PI4K2A RPS6 JAK1 IL2RA JAK2 BTK MYC MAPK14 CXCL8 IL7R MAPK8 LCK EIF4EBP1 TSLP MAPK1 MAPK3 RELA LYN RELB CISH FES HCK PIK3CA CRLF2 TNFSF4 IL6 FYN MTOR STAT5B YES1 AKT1 STAT5A MAPK9 GAB2 STAT6 MAP2K1 SRC MAP2K2 Thyroid hormones production and their peripheral downstream signaling effects WP4746 DUOX2 TRH RPS6KB1 MAP4K5 TTF2 TSC1 RPS6 DIO2 DIO1 ADRB3 CTNNB1 ADCY8 NHSL1 PNPLA2 IYD SHH PPARGC1A ZNF516 MGLL FOXO1 DIO3 TSHR TSHB PRKG2 ITGB3 MAPK1 FRS2 WNT4 TPO AQP7 RPS6KA6 CASP9 ATF2 MTOR NOTCH1 PRKCQ PLIN1 ITGAV ACTL6B TSC2 PPARG NPY SRC PAX8 SLCO1C1 THRB TBC1D4 THRA RXRA DUOXA2 POMC SOS1 HRAS KDM1A MDM2 BAD KDM3B GRB2 MAPK14 RPTOR SLC16A10 KLB SLC16A2 RHEB SIRT6 SLC5A5 FGF21 MLST8 NPR1 TP53 RAF1 TG PRDM16 AGRP MAFA PIK3CA PLCB1 TTF1 FGFR1 UCP1 SLC26A4 MC4R GSK3B AKT1S1 ITPR2 AKT3 PRKACA ADCY3 MAPKAPK3 CREB3 MAP2K1 NPPA PFKFB2 NPPB SECISBP2L Thyroid stimulating hormone (TSH) signaling pathway WP2032 RPS6KB1 PDE4D TTF2 KCNIP3 FOS CREB1 RPS6KA1 IGF1R RPS6 CDK4 JAK1 BRAF CDK2 JAK2 MYC PLD1 RBL2 TSHR TSHB MAPK1 MAPK3 RAP1A CDKN1B RAP1B RAP1GAP MTOR AKT1 APEX1 RALGDS E2F1 SRC PAX8 JUN STAT1 STAT3 GNAI2 HRAS GNAI1 CGA GNA12 GNG2 CCND3 MAPK14 CCNE1 GNA13 EGR1 PIK3R1 PIK3R2 RAF1 GNB1 PIK3CA PLCB1 TTF1 PDPK1 SCRIB MAP2K6 GNAS GNAQ GNAO1 GNAI3 ADCY2 ADCY3 MAP2K1 MYL12B MAP2K3 RB1 Thyroxine (Thyroid Hormone) Production WP1981 TSHR TRH TG SLC5A5 CGA TPO TLR4 Signaling and Tolerance WP3851 IKBKE TRAF3 TRAF6 NFKB1 TIRAP NFKBIA TNF IRF3 TICAM1 IFNB1 CXCL8 IRAK1 TAB1 INPP5D TLR4 MAP3K7 IKBKB TAB2 TBK1 IL6 CHUK TRAM1 IRAK4 RIPK1 IKBKG IRF7 IRAK3 MYD88 TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway WP2036 TRAF3 FADD TRAF2 NFKB1 NFKB2 TRAF5 CCL5 NFKBIA NFKBIB TNF HDAC1 TRAF1 MAP3K14 BIRC3 CTNNB1 MAPK14 MAPK8 CCL2 CASP3 RAC1 MAPK1 MAPK3 RELA RAF1 RELB MAP3K7 TNFSF12 IKBKB GSK3B IL6 CHUK CASP7 TRIM63 TNFRSF12A CASP8 RIPK1 AKT1 BIRC2 AKT2 MAPK9 MMP9 JUN TNF-alpha signaling pathway WP231 FADD CUL1 CDC37 TNF NRAS HSP90AA1 MAP3K14 CYBA CSNK2A1 RFFL BCL2L1 APAF1 TANK CCL2 TRAP1 BID KSR1 CASP3 TAB1 DIABLO TNFRSF1A PTPRCAP TNFRSF1B MAPK1 MAPK3 MAP4K2 SELE MAP3K7 TXN PRKCZ FBXW11 TBK1 IL6 PSMD2 CHUK CASP7 GLUL CASP8 CASP9 CREBBP AKT1 PLK1 RIPK1 TNFAIP3 MAP3K1 BIRC2 MAP3K3 RIPK3 MAP3K5 KRAS JUN TRAF2 NFKB1 NFKB2 NFKBIA NFKBIB SMPD2 NFKBIE SOS1 NOXO1 HRAS TRAF1 BIRC3 BAD GRB2 MAPK8 BTRC PPP2CA RAC1 PYGL OTUD7B MADD RAF1 SKP1 IKBKB TAB3 BAX TAB2 MAP2K6 MAP3K8 MAP2K7 NOX1 RFK KSR2 NSMAF IKBKG MAPK9 MAP2K4 REL CFLAR TRADD MAP2K3 Toll-like Receptor Signaling Pathway WP75 FADD CCL4 CCL5 TOLLIP CCL3 MAP3K7 LBP IRAK4 MYD88 TRAF3 IKBKE CD14 CXCL11 TRAF6 TIRAP TLR5 STAT1 IRF3 TICAM1 IRAK1 PIK3CG PIK3R1 PIK3R2 MAPK12 RELA IKBKB PIK3CA PIK3CB PIK3CD MAP2K6 MAP2K7 CD80 TLR8 CD86 AKT3 IRF5 MAPK11 IRF7 MAP2K4 MAPK9 MAPK10 MAPK13 MAP2K1 MAP2K2 MAP2K3 TNF IFNA5 FOS IFNA4 IFNA2 LY96 IFNA1 TLR7 IL1B CD40 TLR6 TAB1 TLR4 TLR3 MAPK1 MAPK3 TICAM2 IFNA21 IFNA17 PIK3R5 TLR2 TLR1 IFNA16 TBK1 IFNA14 IL6 IFNA13 IFNA10 CHUK IFNA8 CASP8 IFNA7 IFNA6 RIPK1 AKT1 AKT2 JUN NFKB1 SPP1 NFKBIA NFKBIB MAPK14 IFNB1 CXCL8 IFNAR2 IFNAR1 MAPK8 PIK3R3 RAC1 CXCL9 IL12B TAB3 IL12A TAB2 MAP3K8 IKBKG TLR9 CXCL10 Toll-like Receptor Signaling related to MyD88 WP3858 TRAF3 IKBKE TRAF6 NFKB1 TLR5 TIRAP NFKB2 IRF3 TICAM1 TLR7 TOLLIP IRAK1 TLR6 TLR4 TLR3 MAPK1 RELA RELB TICAM2 IKBKB TLR2 TLR1 TBK1 CHUK TLR8 IRAK4 IKBKG IRF7 TLR9 REL MYD88 TP53 network WP1742 SUMO1 ABL1 TNFSF10 TP53 PMAIP1 OTX2 TP73 BAX ATM MDM2 CDKN2A BCL2 MYC CDKN1A BBC3 BOK TP63 BID GADD45A Trans-sulfuration and one-carbon metabolism WP2525 SHMT2 MTHFD1L AHCY DNMT3L SHMT1 MTHFD2L PSAT1 AMT AHCYL2 CBS BHMT DHFR MTHFD1 MTHFR GCLC MTR MTHFD2 TYMS MAT1A MAT2A PHGDH CTH DHFR2 DNMT3B DNMT3A DNMT1 AHCYL1 GCLM MAT2B PSPH GSS Trans-sulfuration pathway WP2333 DNMT1 GCLM MAT2B CBS AHCY MPST CTH GOT1 MTR CSAD Transcription co-factors SKI and SKIL protein partners WP4533 LATS1 TEAD2 TEAD4 SKIL TEAD1 SKI TEAD3 HDAC3 LATS2 HDAC1 SATB2 SIN3A ING2 PRMT5 NF1 STK3 MERTK MECP2 Transcription factor regulation in adipogenesis WP3599 IRS2 RXRA NRIP1 TNF CREB1 ADIPOQ TWIST1 CEBPD CEBPB CEBPA IL6 LPIN1 NR3C1 MAPK8 PPARGC1A PPARG INSR PCK2 LEP SLC2A4 IRS1 FOXO1 Transcriptional cascade regulating adipogenesis WP4211 SREBF1 CEBPG KLF15 CEBPD CEBPB CEBPA GATA3 GATA2 KLF5 PPARG KLF2 EGR2 DDIT3 Translation Factors WP107 EIF2B5 EIF2S2 EIF2B3 LOC101930123 EIF2B2 EIF2B4 EEF2K EIF4B ETF1 EIF4A2 EIF4A1 EIF2AK2 EEF2 EEF1G EEF1D EIF4EBP2 EIF4EBP1 EIF4E EEF1B2 EIF3B EIF3C EIF3A EIF3G EIF6 EIF3H EIF3D EIF3F EIF5A EIF5 EIF4G1 EIF5B EIF3E EIF4G3 GSPT2 EIF1AY EIF2AK1 EIF4H EEF1A2 EIF3I EIF3J EEF1A1 PABPC1 CLUH EIF2AK3 EIF3CL EIF2S1 EIF1AX EIF1 PAIP1 EIF4EBP3 EIF2S3 EIF2B1 Translation inhibitors in chronically activated PDGFRA cells WP4566 PRKCD PDK1 RPS6KA2 RPS6KB2 RPS6KB1 EIF4G3 PIM2 RPS6KA1 RPS6 EIF4B CSNK2A1 EIF4A2 EIF4A1 MAPK14 RPTOR MAPK8 PRKCA PIK3R3 EIF4EBP1 EIF4E PIK3CG PIK3R1 PIK3R2 MAPK1 MAPK3 RPS6KA4 PIK3CA RPS6KA5 PIK3CB PIM1 MAP2K5 MAP2K6 PDCD4 MAP2K7 EIF4G1 MTOR PRKACA AKT3 AKT1 MAP2K4 MAPK9 AKT2 MAPK10 MAP2K1 MAP2K2 MAP2K3 Triacylglyceride synthesis WP325 DGAT1 PLPP1 LIPF PLPP2 MOGAT2 DGAT2 AGPAT5 MOGAT1 AGPAT3 PNPLA2 AGPAT4 MOGAT3 AGPAT1 AGPAT2 GNPAT AGPS LPL LIPC LIPE GPAM GK2 GK GPD1 PLPP3 Tryptophan catabolism leading to NAD+ production WP4210 AFMID KMO NMNAT3 KYNU QPRT NMNAT2 HAAO NADSYN1 NAPRT NMNAT1 NMRK1 NMRK2 AADAT IDO1 TDO2 NAMPT Tryptophan metabolism WP465 AFMID CYP7B1 TPH1 AOC1 ALDH1A2 ACMSD INMT CYP3A4 AADAT CYP2A13 ALDH1A1 CYP2J2 ECHS1 ALDH2 AOX1 ASMT DHCR24 MAOB OGDH CYP4F12 WARS AANAT ACAT1 KYNU CYP2F1 CYP2E1 PRMT1 HADH HAAO DDC CYP1B1 ALDH9A1 CYP1A2 CYP19A1 CYP1A1 ALDH3A2 HSD17B10 IDO1 CYP2C18 TDO2 CAT GCDH Tumor suppressor activity of SMARCB1 WP4204 DPF3 SMARCA4 SMARCC1 SMARCB1 DPF1 CDK6 H3F3B H3F3A CDK4 SMO EZH2 SMARCC2 EED SMARCD2 SMARCD1 DPF2 SMARCE1 SMARCD3 ARID1A SUZ12 ARID1B GLI1 CDKN2A RBBP4 ACTL6B GLI4 GLI3 ACTL6A PTCH1 RB1 GLI2 Type 2 papillary renal cell carcinoma WP4241 CUL2 TGFB3 VEGFA EPAS1 EP300 TGFB1 FH TGFB2 CTSK COL21A1 ELOC RBX1 CADM2 ELOB ARNT2 DVL2 HIF1A SFPQ PDGFB EGLN3 TGFA EGLN2 TFE3 EGLN1 BIRC7 CDKN1A CREBBP SLC2A1 TFEB ARNT PRCC DIAPH1 VHL SETD2 Type I collagen synthesis in the context of Osteogenesis imperfecta WP4786 P3H1 TNFRSF11A CRTAP P4HA2 MIA3 SP7 MBTPS2 SERPINH1 IFITM5 COL1A2 COL1A1 PPIB FZD1 LRP6 LRP5 PLOD1 P4HA1 PLOD2 SERPINF1 TNFSF11 P4HB CREB3L1 TNFRSF11B MBTPS1 WNT1 TMEM38B ITPR1 P3H2 LOX FKBP10 BMP1 ADAMTS2 COLGALT1 Type I interferon induction and signaling during SARS-CoV-2 infection WP4868 IKBKE TRAF3 TRAF6 IFIH1 STAT2 STAT1 TREML4 IRF3 DDX58 JAK1 TLR7 IFNAR2 IFNAR1 EIF2AK2 OAS3 MAVS TLR6 IRF9 TYK2 TLR4 TLR3 TMPRSS2 ACE2 TLR2 TBK1 OAS1 OAS2 IRAK4 IRF7 TLR9 MYD88 Type II diabetes mellitus WP1584 PRKCD MAPK1 TNF SOCS4 PHKA2 PDX1 ADIPOQ IKBKB MAFA PIK3R5 PRKCZ INS-IGF2 GK CACNA1A MTOR MAPK8 INSR SURF1 SLC2A2 SLC2A4 IRS1 KCNJ11 Type II interferon signaling (IFNG) WP619 SOCS1 PRKCD TAP1 PTPN11 STAT2 STAT1 IRF2 IRF4 IFNA2 IFNGR2 SOCS3 ICAM1 HIST2H4A CYBB JAK1 IFNGR1 JAK2 IFNG IFNB1 IFIT2 IL1B PSMB9 EIF2AK2 SPI1 ISG15 NOS2 IRF9 IRF1 CIITA CXCL9 IRF8 IFI6 OAS1 HLA-B GBP1 REG1A CXCL10 Type III interferon signaling WP2113 TYK2 IFNL2 JAK1 STAT2 IL10RB IFNLR1 STAT1 IFNL3 IRF9 IFNL1 TYROBP causal network in microglia WP3945 TGFBR1 CXCL16 PLEK SFT2D2 ITGAM SLC1A5 PYCARD GAL3ST4 RPS6KA1 MAF SH2B3 CD37 GIMAP2 IL13RA1 ZFP36L2 ADAP2 C1QC NCF2 ABCC4 APBB1IP C3 NPC2 TNFRSF1B LYL1 CREB3L2 NRROS IGSF6 LHFPL2 LGALS9C ELF4 CYTL1 GPX1 PPP1R18 CD4 BIN2 RNASE6 ITGAX ITGB2 IL18 FKBP15 SPP1 CD84 GAPT HLX HCLS1 RGS1 SAMSN1 TCIRG1 NCKAP1L LGALS9B SLC7A7 KCNE3 RUNX3 IL10RA TYROBP TMEM106A CAPG STAT5A DPYD RBM47 LOXL3 Unfolded protein response WP4925 TNFRSF10B PMAIP1 PPP1R15A MBTPS2 BCL2L11 BCL2 IL1B CASP2 BID ERN1 XBP1 NFE2L2 ATF6 TP53 MBTPS1 EIF2AK3 EIF2S1 RTCB BBC3 TXNIP CASP8 ATF4 DDIT3 HSPA5 Urea cycle and associated pathways WP4595 NAGS CPS1 MDH1 MDH2 FH ARG1 GLUD1 GLS2 GPT ASS1 ASL ALDH4A1 SLC25A13 SLC25A12 PYCR1 NOS1 OAT GOT2 SLC25A15 NOS2 OTC GOT1 NOS3 LDHB Urea cycle and metabolism of amino groups WP497 NAGS PYCR3 CPS1 GAMT CKB ARG1 ARG2 GLUD1 CKM ASS1 ASL SMS PYCR1 ALDH18A1 ODC1 SRM OAT OTC ACY1 GATM SARDH Urea cycle and related diseases WP4571 NAGS GLS2 ASS1 ASL SLC25A13 CPS1 SLC25A15 OTC ARG1 Valproic acid pathway WP3871 ACADSB ABAT HADHB HDAC1 HADHA ACSM1 EHHADH CYP2B6 HSD17B10 UGT1A3 IVD CYP2A6 CYP2C9 VEGFA-VEGFR2 Signaling Pathway WP3888 OCLN CLTC TBCA FOXO3 LMAN1 FOXO1 NOS3 GAB1 TPCN2 LDB2 PNP LUC7L FLNB PXN FLII CSRP2 CSRP1 NOTCH4 SCUBE2 RPL10A PSMD11 GIPC1 MYH11 TRAF3IP2 FLT1 ARPC5L CALR PSMD4 CALU RCN1 ELOC ELOA MYH9 IDH2 KDR RELA MYO1C CTNNA1 CTGF SLC2A14 HYOU1 MAP2K6 CAMKK2 MAP2K7 HSPA1A FN1 CDH5 GJA1 DNAJA1 MAPK9 CAPN2 MYL2 MAP2K1 MAP2K2 MAP2K3 NFATC1 NFATC2 CREB1 FHOD1 HSP90AA1 SLC25A25 SND1 HSPB1 CTNNB1 RND1 CAPZB MYO6 ASCC3 ITGB3 ITGB5 FGA EIF2A TXNIP CNP ETS1 CREBBP GAPDH LRRC59 ATF2 MTOR ITGAV PTGS2 ITGB1 RAB4A SRC PTK2 RAB5A NFKB1 NFKBIA NAP1L1 EWSR1 PBXIP1 SRP54 CRK CXCL8 GIGYF2 ELK1 FGB CRIP2 AFDN SRF CAV1 FOXO4 PPP2CA PTMA RAC1 DKK1 PTPN1 PPP3CA RAF1 ENG AP2S1 COPG1 CBL MAPKAP1 MMP2 SRPK1 STIP1 MMP10 NCK1 PTPN9 NCL PTPN11 PDIA6 PTPN14 IGFBP3 FHL2 F3 PRKD2 MMRN2 FGG CDC42 MMP14 HTRA1 NCF2 PTPN6 FSCN1 SSR4 HDAC5 SSR3 MEF2C VPS39 SHC2 INPP4B PTPRJ SELE MOV10 ZNF555 CFL1 PRRC2C CYR61 CLIC1 IGFBP7 ZC3H15 EPB41 DPM1 ARNT MAP3K5 ATP6V1E1 ARRB2 WASF1 PRKAA1 STAT1 PLA2G4A PRKAA2 PLA2G5 STAT3 HRAS HLX ICAM1 TMEM170A BMP2 EPHB2 RCAN2 TAL1 NRP2 SOD2 IQGAP1 MAPK12 PLCB3 MLST8 SLC7A1 SARS PTK2B NRARP EPS15 BMX PBK CACNA2D1 AKAP2 ANXA1 IER5 EPRS HMGB1 MAP2K4 STAT6 PLAU TNFRSF25 SET PLAUR PRKCD PRKCE PRKCI P4HA2 PRKD1 ERG HBD NR4A1 RPL13A PLCG1 SLC8A1 PRKCA PRKCB PFN1 CCT7 ERN1 PRKG1 PGK1 MAPK1 MAPK3 PLOD3 VAV2 YWHAE PRKCZ BSG DLL4 AKT1 PGD PGF CYCS HERPUD1 ARHGEF15 VEGFA ADAM9 HDAC1 BIRC5 ALB MAPK8 RPS11 VCL NEXN SYNJ1 ADAMTS9 SHB EZR PPM1G SLC25A11 SHC1 RAB11A HDAC9 PPP1CA SDF2L1 ADAM10 ATF4 ALDOA TUBB8 FADD RAB37 SMARCA2 NUMB EEA1 SIAH2 NAPA CHAC1 CCND1 BCL2 FAS BCL2L1 SHROOM2 KATNAL2 CCL2 INPP5K ADAMTS1 P4HB FXR2 EIF3H DNAJB9 EIF3D EIF3F RPL5 FJX1 FBXW11 S1PR1 TUBA1C TNFRSF10C TRPC1 MAPKAPK5 TRPC3 ABL1 MICAL2 RICTOR EPN1 MDM2 ARF4 HDAC4 RPL7 ACACA ACACB RPL18A PIK3R1 ARMCX1 PIK3R2 SDCBP TMOD1 TMSB4X UBAP2L PAK1 PIK3CA PDPK1 ARF6 RHOA RHOC AKT1S1 PRKRA RPL27 PRDX2 RPL26 TEAD4 BIN1 PAK2 ADRB2 HDAC7 MKNK1 PDE4DIP FARSB ACP1 ABCF2 AP2A1 LARP7 C15orf39 RCAN1 SPIRE1 DSC1 BCAR1 QKI TFCP2 TNXB TRIP4 TFAM FAF1 HBEGF ACTG1 NDRG1 EGR1 GRSF1 RACK1 CDC42BPB PABPC1 BRD4 ACOT9 JAG1 EIF2AK3 RPLP2 GSK3B EGR3 DHX29 LRRFIP2 GPC1 EPHA2 DUSP5 NR4A3 TAOK2 RBM39 USP10 RPS6KB1 PRDX6 CASC10 FMNL3 RPS6 APOLD1 EIF4E ATP6V0D1 ROCK2 ATF6 STAM FRS2 TPM3 ITCH TXN TXNDC5 CTNND1 EIF4G2 EIF4G1 CGNL1 KL DHX36 TMOD3 ROCK1 ACKR3 LDHA RPS6KA5 NCF1 CCDC124 HGS NOX4 MAPKAPK2 RHOJ TKT CYBB GLUD1 GATA2 NR4A2 CCRL2 AMOT RAP1A GPX1 DECR1 RAP1B SEMA6D JUN SH2D2A TMSB10 DNAJB4 KANK1 BMP10 RAPGEF1 CYP2C8 GRB10 FUT1 DOK1 GRB2 MAPK14 FGD5 KCNC3 FYN CSK FAM120A TPP1 LIMK1 SH3BGRL3 OCRL PTPRZ1 Vitamin A and carotenoid metabolism WP716 DGAT1 DHRS3 LRAT RXRA ALDH1A2 RXRG RXRB CRABP2 CRABP1 RDH5 RARB NPC1L1 RARG BCO2 ALDH1A1 RDH12 SULT2B1 RARA ABCG8 ABCG5 RPE65 MAPK1 AWAT2 LPL RBP4 CYP2E1 RDH10 CYP26A1 RBP7 ALDH1A3 RBP2 SULT1A1 ADH1A RETSAT ADH4 BCO1 SDR16C5 RLBP1 CYP26B1 CD36 RDH8 SCARB1 RBP1 Vitamin B12 Disorders WP4271 MMAB MUT CUBN MTRR MMADHC GIF MMACHC MMAA CD320 AMN MTR TCN2 TCN1 Vitamin B12 metabolism WP1533 SHMT2 PLG MMAB CCL5 TNF F7 HBB HBA1 F2 CBS IL1B INS CCL2 MTHFR TCN2 TCN1 SERPINA3 MAT1A SAA2 CUBN SAA1 ABCA1 IL6 INSR NFKB1 NFKB2 MUT MPO MTRR LRP2 GIF ICAM1 SAA4 IFNG ALB APOA1 APOB SOD1 SOD3 MTR SOD2 SERPINE1 RELA CTH LDLR CRP APOE MCEE PLAT SCARB1 Vitamin B6-dependent and responsive disorders WP4228 PIGV ALPI ALDH7A1 PNPO AASS Vitamin D in inflammatory diseases WP4482 NFKB1 NFKBIA RXRA SMAD3 RELA TNF SMAD4 PPP3CA VDR NFATC1 IKBKB MED14 DUSP1 MAP2K6 IL6 CHUK MAPK14 NR3C1 IKBKG PPP3R1 MAP3K1 MAP2K3 Vitamin D Metabolism WP1531 RXRA VDR PTH RXRB CYP27B1 CYP27A1 DHCR7 CYP24A1 CYP2R1 GC Vitamin D Receptor Pathway WP2877 TPM1 HLA-DRB1 IGFBP3 CYP7A1 KRTAP12-2 IGFBP1 TGFB1 KRTAP8-1 TGFB2 IGSF9B CCND1 HLA-DQA2 HLA-DQA1 CYP3A5 MYC CYP3A4 BTLA BGLAP CBS CYP2S1 CEACAM1 CDC34 DUSP10 DNER MX2 PRDM1 FOXO1 HIF1A THBD STAM TNFRSF11B CYP27B1 CYP24A1 TNFSF4 ALOX5 CLDN2 DACT2 TRPV5 CST1 ID4 ALPI IGFBP5 CA9 KRT34 SLC2A4 CD9 CD14 KL RXRA CREG2 IRF4 HILPDA ATP2B1 ALPG EPHB4 HNF1A CCNC CRACR2B STS BMP6 SERPINB1 CST6 CCNE1 CD200 COLEC11 ATP2C2 TRPV6 MXD1 TIMP2 DND1 TIMP3 TNFSF11 NRIP1 TRAK1 KRT38 SFRP1 ID1 CTLA4 IRF8 KNG1 SULT1C2 ADRA1B CLEC16A CAMP CLMN IRF5 RASGRP1 SEMA3B LPGAT1 GADD45A S100A2 S100A4 ASAP2 MYO9B S100A6 ITGAM PTH S100A8 NFATC2 KRTAP5-1 LCE2B KRT71 ADRB2 CDK2 S100G GXYLT2 CRACR2A DEFB132 SATB1 SLC8A1 PTGER4 SULT2A1 CD40 CASP5 SLC37A2 MED9 KLF4 LCE1D CDKN2D CDKN2C LRRC25 CDKN2B HSD17B2 S100A9 LCE1F COL13A1 JUNB KRTAP10-9 CDKN2A KRTAP10-2 CDKN1B CYP1A1 STEAP4 CDKN1A KRTAP10-4 KRTAP10-7 G0S2 PRKCQ PPARD TNFAIP3 BCL6 PTHLH EFNA5 LGALS9 NINJ1 KRTAP4-1 ZNF257 SPP1 ABCB1 VDR SOSTDC1 ORM1 KRT13 FGF23 TREM1 IL25 CYP2B6 SALL4 CASP14 DEFB4A ABCD1 CLPTM1L ADGRE5 CYP2C9 LRP5 ADAMTS5 KLK6 IL12A CEBPA IL1RL1 SLC34A2 CYP2D6 BDKRB1 CDX2 NOX1 KRTAP5-4 CDKAL1 ORM2 PNOC SPRR1B G6PD KRT16 Vitamin D-sensitive calcium signaling in depression WP4698 TPH1 RXRA VDR ATP2B1 ATP2B2 ATP2B3 KDM1A ATP2B4 GGTLC1 PVALB CALB1 BCL2 LOC102724197 CACNA1C TPH2 SLC8A1 GRIN2D ITPR3 GCLC GRIN2C GRIN2B GRIN2A GRIN1 GGT2 NFE2L2 GGTLC2 CYP27B1 CYP27A1 KDM6B KDM1B CHRM1 GGT1 ITPR1 ITPR2 KCNQ2 KCNQ3 KDM3A GRM5 GSR G6PD GPX4 White fat cell differentiation WP4149 NR2F2 IRF3 IRF4 CREB1 KLF15 WNT10B RORA GATA3 GATA2 TCF7L1 INS NR3C1 EGR2 EBF1 FOXO1 RARA NR1H3 SREBF1 KLF4 MECOM CTNNA1 TLE3 CEBPD CEBPB CEBPA KLF5 STAT5B PPARG STAT5A KLF2 DDIT3 ZNF423 Wnt signaling in kidney disease WP4150 WNT9B WNT10B WNT2B WNT11 DVL1 WNT16 CTNNB1 WNT10A FZD5 FZD3 MAPK8 DVL3 DVL2 LRP6 WNT3 FZD1 LRP5 WNT3A WNT2 FZD4 WNT6 WNT5A WNT7B FZD8 WNT7A FZD9 FZD6 FZD7 WNT4 WNT1 RHOA WNT5B FZD2 INVS MAPK9 MAPK10 Wnt signaling pathway and pluripotency WP399 EP300 NKD2 DVL1 CCND1 MYC CSNK1E DVL3 DVL2 MAP3K7 PPP2R3B WNT4 NKD1 CTNND1 NANOG FRAT1 AXIN1 PAFAH1B1 AXIN2 WNT16 CCND2 RACGAP1 CCND3 FZD3 FZD5 NLK WNT3 FZD1 WNT2 FZD4 WNT6 WNT5A FZD8 WNT7B WNT7A FZD9 FZD6 PPM1J FZD7 WNT1 RHOA ZBTB33 LDLR CTBP2 CTBP1 MAP2K4 MAPK9 FZD10 TCF7 SOX2 MAPK10 PLAU TCF7L2 WNT9B PRKCD POU5F1 PRKCE PRKCG PRKCH PRKCI PRKD1 TPTEP2-CSNK1E WNT10B WNT2B WNT11 TCF7L1 CTNNB1 WNT10A ESRRB PRKCA PRKCB NFYA FBXW2 FOSL1 PRKCZ CD44 APC LEF1 CREBBP LRRK2 PPARD PRKCQ JUN PPP2R2A PPP2R2B PPP2R1B FOXD3 PPP2CA PPP2CB PPP2R1A LRP6 WNT3A LRP5 TP53 GSK3B FZD2 WNT5B PPP2R2C PPP2R3A PTPA MMP7 PPP2R5C PPP2R5E Wnt Signaling Pathway WP363 PRKCG TSC1 TPTEP2-CSNK1E NFATC2 CDK6 PI4K2A DVL1 CCND1 MYC CTNNB1 CSNK1E CSNK1D CSNK1A1 CSNK1G1 PRKCA PRKCB ROR2 DVL3 DVL2 TEK MAPK1 MAP3K7 LEF1 APC MTOR AKT1 PPARG TSC2 FRAT1 ARRB2 BCL9 AXIN1 AXIN2 PIP5K1B GCKR TCF3 MAPK8 RAC1 NLK TCF4 LRP6 LRP5 GSK3B RHOA GSK3A GJA1 CTBP1 ROR1 SOX1 RYK MAPK9 TCF7L2 Wnt signaling WP428 CSNK2B CSNK1A1L PRICKLE1 NKD2 DVL1 CSNK2A2 CCND1 DKK4 CSNK2A1 KREMEN1 MYC CSNK1E CSNK1A1 DKK2 PPP3CC PPP3R1 PPP3R2 DVL3 DVL2 ROCK2 SOX17 MAP3K7 WIF1 PORCN VANGL1 PRICKLE2 WNT4 CER1 NKD1 INVS FRAT1 SOST AXIN1 WNT16 CCND2 CCND3 CSNK2A3 FZD3 FZD5 CAMK2A CAMK2B NLK CAMK2D CAMK2G FZD1 WNT3 WNT2 WNT6 WNT5A SERPINF1 PLCB2 FZD8 WNT7B PLCB3 WNT7A FZD9 PLCB4 FZD6 SFRP2 FZD7 SFRP1 WNT1 RHOA CTBP2 ROR1 CTBP1 RYK MAPK9 FZD10 TCF7 PLAU TCF7L2 PRKCG NFATC1 TPTEP2-CSNK1E NFATC2 CXXC4 DAAM1 WNT10B FRAT2 WNT2B NOTUM WNT11 TCF7L1 CTNNB1 WNT10A SFRP5 PRKCA SFRP4 PRKCB ROR2 FOSL1 GPC4 APC LEF1 NFATC3 NFATC4 JUN CHD8 SENP2 DAAM2 CTNNBIP1 MAPK8 RAC1 LRP6 DKK1 WNT3A LRP5 PPP3CA PPP3CB PLCB1 GSK3B VANGL2 WNT5B FZD2 Wnt/beta-catenin signaling pathway in leukemia WP3658 AXIN2 CCND1 MYC TCF3 CTNNB1 SALL4 FLT3 CSNK1A1 RARA DKK1 PML LRP6 LRP5 FZD6 WIF1 PYGO1 WNT1 GSK3B JUP RUNX1T1 LEF1 APC PPARD AKT1 ZBTB16 BCL9 Zinc homeostasis WP3529 SLC30A3 SLC30A2 MT1E MT1F SLC30A4 MT1G MT1H SLC39A8 SLC39A2 SLC39A10 SLC39A6 SLC39A13 MT1B SLC39A11 SLC39A3 SLC39A12 MT1A MT1X SLC30A1 MT2A MT3 MT4 SLC39A14 MTF1 SLC30A5 SLC39A4 SLC30A7 SLC30A8 SLC39A1 SLC30A6 SLC39A9 SLC30A10 MT1M SLC39A5 SLC39A7 SLC30A9