association	dataset	threshold value	standardized value
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06564
OVCAR8	CCLE Cell Line Gene Mutation Profiles	1.0	null
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43061
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.336
pii	GeneRIF Biological Term Annotations	1.0	null
purine ribonucleoside binding	GO Molecular Function Annotations 2015	1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.247
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.205
G122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41434
GSE165334_3_v_0_dabrafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09955
BRD-K64535513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30469
acute myeloid leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.080319
BRD-K85357344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16296
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.339
PMC5732738-oncotarget-08-103415-s002.xlsx-MFC-7_DEGs-Genes_with_significantly_different_expression_between_parental_MCF-7_and_GATA3_WT_clones_with_adjusted_P_value_0_05_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
Liver	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.547
increased circulating triglyceride level	MGI Mouse Phenotype Associations 2023	1.0	null
carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051337
fatty acid transmembrane transport	GO Biological Process Annotations 2015	1.0	null
Testicular Diseases	CTD Gene-Disease Associations	1.0	1.37303
organonitrogen compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
RERFGC1B	CCLE Cell Line Gene CNV Profiles	1.0	1.35652
Perturb_10832_KO_Xbp1_SRP197108	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.64781
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861017
HCC2218	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.05013
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
wt1_00000000_mouse_embryonic_fibroblast_mef_lof_mouse_gpl1261_gse15325	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.943001
Glucose transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.135
Lateral reticular nucleus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26386
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01729
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10588
outer SZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0709
NCI-H23	COSMIC Cell Line Gene Mutation Profiles	1.0	null
centromedian nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.908163
Perturb_4177_KO_Dnmt1_SRP043000	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.66626
abnormal behavior	MGI Mouse Phenotype Associations 2023	1.0	null
KMS27	CCLE Cell Line Gene Expression Profiles	1.0	1.40211
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16116
Central Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.21951
BRD-K79967274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10097
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.854662
GSE178714_5_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.204
GSE169697,GSE169725_0_v_5_prrx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Leg muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.956
GTEX-XUYS-0226-SM-47JX1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939304
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.788
Foot	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.336
PRDX4	Pathway Commons Protein-Protein Interactions	1.0	null
primary auditory cortex (core)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.60116
GSE212299_3_v_0_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdaloid complex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03009
periventricular stratum of Pal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11742
oxide	Phosphosite Textmining Biological Term Annotations	1.0	null
GSE149123,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A57E-11A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE212486,GSE212488_2_v_3_gata4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.81697
GSE196699_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
layer 1 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.78064
GSE202825_2_v_1_ano1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of lipid storage	GO Biological Process Annotations 2015	1.0	null
DNA replication factor C complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.679
PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST12-Unnamed_8_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
bipolar disorder	GWASdb SNP-Disease Associations	1.0	0.571211
PMC9013128-NIHMS1795992-supplement-4.xlsx-SKmel147_ARID2_KO_Downregulated-Gene_name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12069319-Table1.xlsx-OCAB_WT_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.32247
SCC-9	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21049
IZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.900772
H-508	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.69
GSE160373_6_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37524
Perturb_15358_KO_Tfap4_SRP212619	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.60224
MFE-319	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Upstream stimulatory factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.949
A549_Luminespib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190465
layer 6 of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15858
r6 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.62877
Obesity, Abdominal	HuGE Navigator Gene-Phenotype Associations	1.0	null
C2orf16	Pathway Commons Protein-Protein Interactions	1.0	null
Death	CTD Gene-Disease Associations	1.0	1.02783
SNUC5	CCLE Cell Line Gene Mutation Profiles	1.0	null
BRD-K22380647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5084
hsa-miR-646	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
MCF7	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.07116
Metformin	CTD Gene-Chemical Interactions	1.0	null
Poisoning	CTD Gene-Disease Associations	1.0	1.26917
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG	Reactome Pathways 2014	1.0	null
GSE231648_4_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF582	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5119
CAL33	CCLE Cell Line Gene Mutation Profiles	1.0	null
BRD-K92428232_GSK-461364_HA1E_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11C-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
t58-heart_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.99943
Lung squamous cell carcinoma_LUSC_TCGA-51-4081-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
effects	GeneRIF Biological Term Annotations	1.0	null
DND41	CCLE Cell Line Gene Mutation Profiles	1.0	null
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.842347
GSE111245_0_v_1_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Insulin signaling pathway	KEGG Pathways 2026	1.0	null
SH3BP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38156
TBK1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K13169950_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TE125T	CCLE Cell Line Gene Mutation Profiles	1.0	null
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.913697
Lung adenocarcinoma_LUAD_TCGA-50-5939-11A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
muscle	Phosphosite Textmining Biological Term Annotations	1.0	null
GATA1::TAL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.7088
DMS-114	GDSC Cell Line Gene Expression Profiles	1.0	1.84482
Reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.248
PMC12623973-41467_2025_64981_MOESM3_ESM.xlsx-downregulated-c0_ACKR4_SCS_ceiling_LEC_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE161295_4_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC9A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00540366
Fatty acid biosynthesis	KEGG Pathways 2026	1.0	null
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.016
ZNF778	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26154
BRD-K75842461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19477
BRD-K62358193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54344
BRD-K86682249_1357397_SW948_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A73741725_EXEMESTANE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Thorax muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.315
GSE211357_2_v_0_atg7_human	RummaGEO Gene Perturbation Signatures	1.0	null
rna-messenger	Phosphosite Textmining Biological Term Annotations	1.0	null
BRD-K41206520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38944
BRD-K73689413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61243
Perturb_14864_KD_ZRSR2_SRP341591	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.60005
chr12_109112798_A_G_b38	GTEx eQTL 2025	1.0	2.71562
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933483
Organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Ventricular Dysfunction, Left	CTD Gene-Disease Associations	1.0	1.02783
Reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.248
BRD-K56411643_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
retinoblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.372369
LTBR_INHIBITION - 27 Day_GDS2004_736_mouse_Lymph nodes  (MG-430A)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
18354499-Table3	GeneSigDB Published Gene Signatures	1.0	null
PMC7300300__F3	PFOCR Pathway Figure Associations 2024	1.0	null
NCOR1	Pathway Commons Protein-Protein Interactions	1.0	null
IPC298	CCLE Cell Line Gene Mutation Profiles	1.0	null
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BRD-K69840402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26322
Fatty acid metabolism	Reactome Pathways 2024	1.0	null
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.05422
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A3JJ-11A-12R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122553
alphaacc1	GeneRIF Biological Term Annotations	1.0	null
adipose tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
KRI1	Pathway Commons Protein-Protein Interactions	1.0	null
habenula	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.246442
NEPRO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45848
myocardium	Phosphosite Textmining Biological Term Annotations	1.0	null
hsa-miR-4695-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.35314
Urogenital Abnormalities	CTD Gene-Disease Associations	1.0	1.84746
GSE246567_0_v_1_acat2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
UBF1/2-26484160-CHIP-SEQ-FIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.857574
BRD-K44432556_VU0418946-2_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SK-NEP-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Dorsal motor nucleus of the vagus nerve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19567
GTEX-PWOO-2226-SM-2S1P1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36378
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE96991,GSE97117_3_v_0_il11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Carnitine shuttle	Reactome Pathways 2024	1.0	null
R3HCC1	Pathway Commons Protein-Protein Interactions	1.0	null
Quadriceps	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.62
PMC4777381-pone.0150624.s006.xlsx-dif_exp_AD-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
SBNO2	Pathway Commons Protein-Protein Interactions	1.0	null
Hepa-1c1c7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.528
GTEX-OIZI-0226-SM-2XCEE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.49408
RPAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82686
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TENM2	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-6776-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE169155_3_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S95S-1326-SM-2XCDK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63349
GSE188721_2_v_4_mesp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228017_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POP4	Pathway Commons Protein-Protein Interactions	1.0	null
IPC-298	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Leg	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.841
GSE65617_5_v_3_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE174701_1_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-384	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
VZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08988
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.39243
BRD-K54606188_(+)-JQ1_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-1910	TargetScan Predicted Conserved microRNA Targets	1.0	0.065994
PMC6187090-mmc1.xlsx-TP53_positive-Symbol_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-548e	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Liver Diseases	CTD Gene-Disease Associations	1.0	2.47494
BRD-K11612998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07016
GSE172020_0_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Mitochondrial outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
SET-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.44172
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.979501
PMC11813851-12672_2025_1910_MOESM3_ESM.xlsx-Sheet1-Table_S2_Results_of_two-sample_drug-target_MR_analyses_for_pancreatic_cancer_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE131887_1_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K86677819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19013
singlenucleotide	GeneRIF Biological Term Annotations	1.0	null
Metabolism	Reactome Pathways 2024	1.0	null
GSE196117_1_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
small heart	MGI Mouse Phenotype Associations 2023	1.0	null
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.78106
GSE131798,GSE131804_1_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7284929__F7	PFOCR Pathway Figure Associations 2023	1.0	null
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.89766
pharmacogenomic	GAD High Level Gene-Disease Associations	1.0	0.293278
GSE192663_3_v_2_acly_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cytosol	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
mitochondrion	GO Cellular Component Annotations 2015	1.0	null
nucleoside bisphosphate metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K56536691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19587
decreased respiratory quotient	MGI Mouse Phenotype Associations 2023	1.0	null
ZNF106	Pathway Commons Protein-Protein Interactions	1.0	null
MDST8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K57282030_JW-7-24-1_LNCAP_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4446-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
BRD-K86630280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42203
subthalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.0297
anion binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-R45C-0008-SM-48FF2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03029
mitochondrion	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.505131
huh-7	BioGPS Cell Line Gene Expression Profiles	1.0	1.24601
cefotaxime-2072	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ACHN	CCLE Cell Line Gene CNV Profiles	1.0	1.88558
Perturb_11331_KO_Nr1d1/Nr1d2_SRP241717	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.42924
budesonide-1716	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Neoplasm Invasiveness	CTD Gene-Disease Associations	1.0	1.18685
GTEX-NL3G-0008-SM-4E3JX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43084
GSE225735_1_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223893_1_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_17412_KO_Kat7_SRP346205	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
HEC1B	CCLE Cell Line Gene Mutation Profiles	1.0	null
MCM4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QEG5-0326-SM-2S1PB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50674
pirenperone-3316	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE102870_1_v_2_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.953388
Tibialis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.006
biotin carboxylase activity	GO Molecular Function Annotations 2015	1.0	null
monocarboxylic acid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
NR3C1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-U3ZM-0008-SM-4DXTQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05282
GSE125403_3_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169155_3_v_7_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Aplasia Cutis Congenita	DisGeNET Gene-Disease Associations	1.0	null
mRNA_NIPBL_20720539	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE210580_4_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ASCL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.0833
Uterine Cervical Neoplasms	CTD Gene-Disease Associations	1.0	1.28456
DMD_Deficiency_GDS2996_613_mouse_Cardiac muscles from 8-week (mdx animals)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
noretynodrel-1860	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
T3M4	CCLE Cell Line Gene CNV Profiles	1.0	1.5765
hsa-miR-4527	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
RCOR3	ChEA Transcription Factor Targets	1.0	null
BRD-K12502280_TG101348_EFO27_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K85064040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05941
GSE210885_5_v_6_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K81142122_STK249718_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K73395020_ARP 101_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Hypertrophy, Left Ventricular	CTD Gene-Disease Associations	1.0	1.30574
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.57522
outer CP in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04668
SIRT1_KO_GDS3666_295_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-S4UY-0226-SM-3K2AP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40155
monolayer-surrounded lipid storage body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.858
BRD-K72681425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51831
Weight Loss	CTD Gene-Disease Associations	1.0	2.14662
GTEX-UJMC-1826-SM-3GADT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26596
Platelet alpha granule membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.373
bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.002594
brown adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.746689
GSE247764_5_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IMR32	DepMap CRISPR Gene Dependency	1.0	2.98332
Cervical cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.248
GTEX-TMZS-0226-SM-3DB9N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845886
Perturb_1666_KO_Rigi_SRP119759	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.46562
BRD-K35960502_NICLOSAMIDE_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Anterior cingulate area, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12215
KRT31	Pathway Commons Protein-Protein Interactions	1.0	null
4h_cisplatin vs ctrl_mESC (Mouse) [22006019]	SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs	-1.0	null
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02783
nucleoside bisphosphate biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GSE229468,GSE229471_2_v_3_znf587_human	RummaGEO Gene Perturbation Signatures	-1.0	null
sulpiride-4389	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K81795824_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventral tier of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41698
AJAP1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_12hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K49865102_PD-0325901_HT29_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YQ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.983361
HEC-1-A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
H3K36me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.246
mantle zone of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71271
GTEX-QDT8-0226-SM-32PL4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06153
COLO668	CCLE Cell Line Gene CNV Profiles	1.0	2.17313
diet	Phosphosite Textmining Biological Term Annotations	1.0	null
Perturb_10795_KO_Xbp1_SRP262377	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.77229
organelle part	GO Cellular Component Annotations 2015	1.0	null
posteroventral (inferior) parietal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.855158
CAL78	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53819
KAT6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46181
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CNP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09225
primary auditory cortex (core)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19702
mRNA_CDX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GSE165682_2_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-R3RS-0008-SM-48FF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963659
CLSTN1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A5EY-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SNMC-1326-SM-2XCFK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44825
PMC6754502-41598_2019_50051_MOESM3_ESM.xlsx-Br_Thermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
connective tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
biotin binding	GO Molecular Function Annotations 2015	1.0	null
RCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.921221
Brain Lower Grade Glioma_LGG_TCGA-HT-7691-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-93-A4JP-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC3639322__F3a	PFOCR Pathway Figure Associations 2023	1.0	null
GSE135030_11_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.958545
BRD-K77908580_S1053_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.968005
MAP3K7	Pathway Commons Protein-Protein Interactions	1.0	null
inorganic anion transport	GO Biological Process Annotations 2015	1.0	null
ATP6V1D	Pathway Commons Protein-Protein Interactions	1.0	null
GSE207914_3_v_6_nudt7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Coronary Heart Disease	DisGeNET Gene-Disease Associations	1.0	null
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02546
Skeletal muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.134
Perturb_17809_KO_Mrp4_SRP293793	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.52204
Perturb_17411_KO_Kat7_SRP346205	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
RPL21	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_11122_KD_Eif3m_SRP162708	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-12.2398
Stroke	CTD Gene-Disease Associations	1.0	1.38835
biotin	GeneRIF Biological Term Annotations	1.0	null
GTEX-WY7C-2726-SM-3NB3P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67361
Skeletal muscle satellite cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.818
EXOC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4996
GTEX-XMK1-1126-SM-4IHJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06758
Postsubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17787
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CCM2L	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02174
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7406-11A-01R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SYNCRIP_OE_GDS1806_82_human_T-lymphocytes from normal donors were activated with anti-CD3 and IL2	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.238
BRD-K05653692_DL-PDMP_LOVO_6.0_h_64.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mitochondrion	LOCATE Curated Protein Localization Annotations	1.0	null
GTEX-S3XE-1626-SM-3K2AJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42001
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.36053
BRD-K17889110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04857
496100478_HIP_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.38128
rosiglitazone_mus musculus_gpl8321_gds4021	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
retinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.177851
GSE131649_2_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A56592690_PX12_HCC515_6.0_h_30.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
vertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.49679
ADAMTS20	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-205	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL2-Unnamed_0_TAL2	Rummagene Transcription Factor Associations 2026	1.0	null
Liver Cirrhosis, Experimental	CTD Gene-Disease Associations	1.0	1.76771
Perturb_11290_KO_Bmal1_SRP153814	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.55853
SNRPF	Pathway Commons Protein-Protein Interactions	1.0	null
GSE196699_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
response to organic cyclic compound	GO Biological Process Annotations 2015	1.0	null
HCC1833	CCLE Cell Line Gene Expression Profiles	-1.0	-3.03529
intertwined	GeneRIF Biological Term Annotations	1.0	null
PMC2335306-1471-2105-9-87.nxml--GATA3_and_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
interpeduncular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.983546
hsa-miR-515-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
BRD-K49328571_dasatinib_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOXG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0352
tilorone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13496
BRD-K76541957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18939
coenzyme biosynthetic process	GO Biological Process Annotations 2015	1.0	null
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
CRCGN011_HEPG2_24H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36625
Perturb_10866_KO_Hsf1_SRP116890	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.56609
GTEX-QCQG-1826-SM-2S1P2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17528
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.876015
BRD-K96164740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03239
GABRR1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875493
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.744
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35051
GSE125007,GSE125008_10_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QCQG-0008-SM-48U2G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872342
Hamstring muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.77
BRD-K71005143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25619
COLO668	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54868
ribonucleoside bisphosphate metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Unnamed_1_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K64571715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2339
Defective AMN causes hereditary megaloblastic anemia 1	Reactome Pathways 2014	1.0	null
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01835
DIFI	DepMap CRISPR Gene Dependency	1.0	3.87146
GSE131649_6_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K78126613_MENADIONE_U937_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K25525067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16688
ERBB2_knockdown_231_GSE8373	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.76633
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975233
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
Hypertension	CTD Gene-Disease Associations	1.0	1.95752
LUZP1	Pathway Commons Protein-Protein Interactions	1.0	null
IGR1	CCLE Cell Line Gene Expression Profiles	1.0	1.50372
ciprofloxacin_pseudomonas aeruginosa; pseudomonas aeruginosa pao1_gpl84_gse12678	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE153443_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
phospholipase	Phosphosite Textmining Biological Term Annotations	1.0	null
ARG1	Pathway Commons Protein-Protein Interactions	1.0	null
muscle	GTEx Tissue Gene Expression Profiles	1.0	1.13265
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.82594
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
r4 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38219
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
BRD-K62193937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.40311
Perturb_10830_KO_Xbp1_SRP197108	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.72133
PF382	CCLE Cell Line Gene Mutation Profiles	1.0	null
BRD-K72317601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36606
GSE231648_4_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RIMS2	Pathway Commons Protein-Protein Interactions	1.0	null
PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-SP1_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.54629
Preadipocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.86
Hyperplasia	CTD Gene-Disease Associations	1.0	2.3702
Defective BTD causes biotidinase deficiency	Reactome Pathways 2014	1.0	null
ATP-independent citrate lyase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.062
HNRNPUL1	Pathway Commons Protein-Protein Interactions	1.0	null
Fibrosis	CTD Gene-Disease Associations	1.0	2.23744
Diarrhea	CTD Gene-Disease Associations	1.0	1.18193
TBL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12233
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.881261
GTEX-N7MS-0008-SM-4E3JI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10527
GSE62292,GSE62295_2_v_0_col4a3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FIRSOCOSTAT	DGIdb Drug Targets 2026	1.0	2.2055
abnormality of carbohydrate metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.200946
A549_Barasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0221204
dorsal thalamus_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.918524
SK-MEL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.99345
organonitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.054
abnormal enzyme/ coenzyme level	MPO Gene-Phenotype Associations	1.0	null
vitamin metabolic process	GO Biological Process Annotations 2015	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05187
P300-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
polymorphic layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.80451
middle ear disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.175947
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45664
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829066
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.80634
BRD-K73637411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68655
Lung adenocarcinoma_LUAD_TCGA-44-5645-11A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11384093-mmc1.xlsx-886-drug_target-VDR_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4390253__F1	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K26104851_Nifuroxazide_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE81193_3_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
layer 2 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.04423
abnormal skin adnexa morphology	MPO Gene-Phenotype Associations	1.0	null
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01192
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03435
purine ribonucleotide biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GSE96641_5_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Fever	CTD Gene-Disease Associations	1.0	1.36304
AGPAT1	Pathway Commons Protein-Protein Interactions	1.0	null
ambroxol-3238	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
overexpression	GeneRIF Biological Term Annotations	1.0	null
TUBG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39878
GSE160083,GSE160084_1_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AGK	Pathway Commons Protein-Protein Interactions	1.0	null
abnormal fatty acid level	MPO Gene-Phenotype Associations	1.0	null
BRD-A36471396_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SAMD9L	Pathway Commons Protein-Protein Interactions	1.0	null
proton-transporting two-sector ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.037
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24291
salivary gland carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.144838
TNR	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.910984
m1 part of paranigral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09371
ATN-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K97534490_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K00910650_NCGC00242335-01_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A82590476_SDZ NKT 343_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE139016_3_v_2_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JHOS2	CCLE Cell Line Gene CNV Profiles	1.0	2.53487
GSE132948,GSE132949_0_v_1_msi2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE137954_4_v_2_smyd3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Interanteromedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1359
GSE223908,GSE223909_4_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.15263
Sarcoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.203
BRD-K58791506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06299
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7250-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE137653_2_v_3_siglecf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Dilated cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
lateral septal nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21718
endothelial	Phosphosite Textmining Biological Term Annotations	1.0	null
training	GeneRIF Biological Term Annotations	1.0	null
Proteinuria	HuGE Navigator Gene-Phenotype Associations	1.0	null
Respiratory chain complex III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.375
citalopram-3903	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A56592690_PX12_SW620_6.0_h_30.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
roles	GeneRIF Biological Term Annotations	1.0	null
CD83	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44766
GTEX-XGQ4-0926-SM-4AT4U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95159
GR	MotifMap Predicted Transcription Factor Targets	1.0	null
hsa-miR-148b-3p	MiRTarBase microRNA Targets	1.0	null
GSE89057_0_v_1_sox5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SK-MES-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
purification	GeneRIF Biological Term Annotations	1.0	null
BRD-A36275421_MW-ras12_SW620_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IGROV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
vascular	Phosphosite Textmining Biological Term Annotations	1.0	null
NCI-H2009	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K04238122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00147
Mitochondrial membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
JJN-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
blood plasma	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.549312
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.58
PALD1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE131649_6_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16886
GTEX-Q2AG-0008-SM-48U2K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61579
ZNF341	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2947
USP48	Pathway Commons Protein-Protein Interactions	1.0	null
reported	GeneRIF Biological Term Annotations	1.0	null
thigh muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.807716
GSE232558_0_v_1_fbxl12_human	RummaGEO Gene Perturbation Signatures	1.0	null
fatty acid biosynthetic process	GO Biological Process Annotations 2023	1.0	null
MPHOSPH9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13787
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-3.10552
tracazolate-7339	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
fulvestrant-6918	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A50774520_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MRPS27	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Triamcinolone Acetonide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00910553
phorbol	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEX-S32W-2026-SM-4AD6E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12606
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06384
layer 1 of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0344
Fatty Acid Biosynthesis(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
B4GALT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0054095
GSE226249_5_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
generation of precursor metabolites and energy	GO Biological Process Annotations 2015	1.0	null
carboxylic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Glioma	CTD Gene-Disease Associations	1.0	1.07234
BRD-K41996876_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HS739T	CCLE Cell Line Gene Mutation Profiles	1.0	null
BRD-K96799727_Pifithrin- ?_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_7030_KO_Erg|Fli1_SRP402910	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-15.5776
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62648
EEF1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-7.82121
LIVF001-027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22595
SNU475	CCLE Cell Line Gene Mutation Profiles	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K40809590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90781
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE192513,GSE192515_2_v_0_atg16l1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNU81	CCLE Cell Line Gene Mutation Profiles	1.0	null
CAL33	CCLE Cell Line Gene Expression Profiles	-1.0	-2.87437
Chromosome Aberrations	CTD Gene-Disease Associations	1.0	1.03122
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.846631
Preadipocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.099
GTEX-XXEK-2426-SM-4BRUS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.992926
GTEx Brain 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	1.0	16.7701
GSE212486,GSE212488_0_v_1_gata4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MC116	CCLE Cell Line Gene Expression Profiles	1.0	1.35751
m1B part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03227
BRD-K52911425_GDC-0941_PC3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
valproic acid-5574	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
carbohydrate derivative metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31116
PANC-10-05	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K69613314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0006
BRD-K76899562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3643
allelespecific	GeneRIF Biological Term Annotations	1.0	null
OVSAHO	CCLE Cell Line Gene Mutation Profiles	1.0	null
BRD-K44287054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05869
A549_Danusertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125194
involvement	GeneRIF Biological Term Annotations	1.0	null
response to stimulus	GO Biological Process Annotations 2015	1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.68
BRD-K09250623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03376
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsal part of alar p3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12947
GSE174735_4_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal heart morphology	MPO Gene-Phenotype Associations	1.0	null
middle-aged	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEX-P4PP-0008-SM-48TDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01322
HOXB5	Pathway Commons Protein-Protein Interactions	1.0	null
COLO 206F	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.851164
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.78
BRD-K99962919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24234
Left_Ventricle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.8885
BRD-K88437756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83716
Squamous cell carcinoma of lung_Lung Tissue_GSE3268	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.83473
nrf1	GeneRIF Biological Term Annotations	1.0	null
SOX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6284
BRD-A16998493_etodolac_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
negative regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
TMPO	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_14700_KO_TET1/TET2/TET3_SRP251780	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
single-organism localization	GO Biological Process Annotations 2015	1.0	null
Hyperinsulinism	CTD Gene-Disease Associations	1.0	1.33494
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
12393420-Table1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.0948
SNB75	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.939098
Primary autosomal recessive microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.031
Organelle outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
NCI-H835	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.11356
KRT10	Pathway Commons Protein-Protein Interactions	1.0	null
Triglycerides Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
Migraine Disorders	CTD Gene-Disease Associations	1.0	1.09646
GSE239844_6_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Acetyl-coenzyme A carboxyltransferase, N-terminal	InterPro Predicted Protein Domain Annotations	1.0	null
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PPP6R2	Pathway Commons Protein-Protein Interactions	1.0	null
PMC8567280-EMBR-22-e53014-s007.xlsx-Sheet1-Nearest_genes_to_BAZ2A-bound_C2-Enhancers_BAZ2A	Rummagene Transcription Factor Associations 2026	1.0	null
KYSE-150	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Adipocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.349
epitiostanol-2922	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Liver Cirrhosis	CTD Gene-Disease Associations	1.0	1.84481
Carcinoma in Situ	HuGE Navigator Gene-Phenotype Associations	1.0	null
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.74297
GSK3B	Pathway Commons Protein-Protein Interactions	1.0	null
SDHA	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11960529-mmc4.xlsx-Ventricular_ZNF711_KOoverCT-gene_ZNF711	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15897
A549_ZM 447439_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121973
A549_Tubastatin A HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147213
frontal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K49434474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03309
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.457
VZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.42164
Acute myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
GTEX-QEL4-0626-SM-3GIJM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03672
BRD-K63154470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93759
PMC11329632-41419_2024_6969_MOESM3_ESM.pdf-114-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
NFIC	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE173578_1_v_0_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mitochondrial membrane	GO Cellular Component Annotations 2025	1.0	null
BRD-K95921201_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KMM1	CCLE Cell Line Gene Expression Profiles	1.0	1.77216
ZZEF1	Pathway Commons Protein-Protein Interactions	1.0	null
Plastid outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.592
BRD-K40016301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08946
BRD-K28120222_Prestw-550_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE213588_9_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE188870,GSE188871_0_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE225218_0_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
protein tetramerization	GO Biological Process Annotations 2015	1.0	null
DB	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-Q2AG-0226-SM-2S1P4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95012
cerebellum	HPA Tissue Protein Expression Profiles	-1.0	-0.885645
MCF7_Vandetanib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0105034
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057306
2313287	CCLE Cell Line Gene Mutation Profiles	1.0	null
orphenadrine-2318	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE219103,GSE219104_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RU72-1326-SM-2TF6T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952222
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.321
Fatty acid elongase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.243
CoA carboxylase activity	GO Molecular Function Annotations 2025	1.0	null
diabetes	GeneRIF Biological Term Annotations	1.0	null
HCT-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8818
nucleobase-containing compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
succinate-CoA ligase complex (ADP-forming)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.567
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47819
purine nucleoside bisphosphate metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37458
PMC3861642__F9	PFOCR Pathway Figure Associations 2023	1.0	null
superior parietal lobule, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15902
MHHES1	CCLE Cell Line Gene Expression Profiles	1.0	2.20224
PDE5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00541027
RAB3A_Mutation - D77G point mutation_GDS2483_698_mouse_Hippocampus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	2.47399
18223198-TableS3	GeneSigDB Published Gene Signatures	1.0	null
KYSE410	CCLE Cell Line Gene CNV Profiles	1.0	1.78793
GSE129725_1_v_5_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Anterodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70401
coenzyme a metabolic process	GO Biological Process Annotations 2015	1.0	null
Metabolic dysfunction-associated steatohepatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.901
GSE166920_6_v_2_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4713-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
PMC9618568-41467_2022_34255_MOESM5_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SN8G-0008-SM-4DM4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55416
A549_Mercaptopurine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135507
Perturb_16731_KO_Myc/Pin1_SRP069191	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.55432
BRD-K63462027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20579
Lingula (I), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.48065
Hereditary leiomyomatosis and renal cell carcinoma pathway	WikiPathways Pathways 2024	1.0	null
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49974
CLEC11A	Pathway Commons Protein-Protein Interactions	1.0	null
Eosinophil_Stomach_Human	CellMarker Gene-Cell Type Associations	1.0	null
BRD-K65598536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35433
lovastatin-2854	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE137144_4_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
acetyl-coa metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-NFK9-0008-SM-4E3JE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.901116
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.851
PMC10901781-41467_2024_46134_MOESM12_ESM.xlsx-Supplementary_Data_9-Supplementary_Data_09_Differential_expressed_genes_in_RUNX1-mutated_AML_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
SNU-719	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.939547
15297395-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
BRD-K68007270_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5469-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.55783
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.855
oxamniquine-2924	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K54606188_(+)-JQ1_HT29_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC8763317-MO-018-D1MO00236H-s002.xlsx-PHF21A_S0_1-Gene_names_PHF21A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149075_1_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OXRK-0326-SM-3NB3R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925928
PK-45H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.928825
r10 part of spinal vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0658
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.870817
A549_WP1066_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139669
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.03978
A549_Triamcinolone Acetonide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00745792
CAOV4	CCLE Cell Line Gene CNV Profiles	1.0	1.50753
QGP1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.61895
COMPOUND 2E [PMID: 31900320]	DGIdb Drug Targets 2026	1.0	4.411
dorsal subnucleus of MG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.73865
isoxicam-1820	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-2662-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
orbital frontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.941401
Malonyl-CoA	MW Enzyme Metabolite Associations	1.0	null
Psychomotor Disorders	CTD Gene-Disease Associations	1.0	1.31746
internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H8-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
characterization	GeneRIF Biological Term Annotations	1.0	null
CRCGN015_MCF10A_48H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07966
Diabetes Mellitus	HuGE Navigator Gene-Phenotype Associations	1.0	null
cognitive disorder	GWASdb SNP-Disease Associations	1.0	0.096731
Aleurone layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.509
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.912597
A549_SB431542_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186331
PK-45H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-QDVN-1126-SM-48TZ7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835668
YWHAB	Pathway Commons Protein-Protein Interactions	1.0	null
GSE125782_0_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Metabolism of lipids and lipoproteins	Reactome Pathways 2014	1.0	null
BRD-K64800655_HY-11001_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Myoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.518
Carcinoma	CTD Gene-Disease Associations	1.0	1.53844
BRD-K76482408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12863
ribonucleoside biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8844
BRD-K18523456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88814
CDCA4	Pathway Commons Protein-Protein Interactions	1.0	null
HIST1H3B	Pathway Commons Protein-Protein Interactions	1.0	null
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.824597
PPP2R3B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.57828
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EB-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16263
demonstrates	GeneRIF Biological Term Annotations	1.0	null
SF3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47493
myocytes-cardiac	Phosphosite Textmining Biological Term Annotations	1.0	null
MCF7	CCLE Cell Line Gene Expression Profiles	1.0	2.79942
PLOD1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10290283-biol-2022-0622-sm3.pdf-103-GPBP1_GPBP1	Rummagene Transcription Factor Associations 2026	1.0	null
protein complex assembly	GO Biological Process Annotations 2015	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Perturb_3168_OE_Rbfox2_SRP186301	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.57346
HuO9	GDSC Cell Line Gene Expression Profiles	1.0	1.60636
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE127790_4_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormality of the cardiovascular system	GWASdb SNP-Phenotype Associations	1.0	0.047249
Atherosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.544
ZNF263-19887448-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-7713-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
benzylpenicillin-6839	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
acc2	GeneRIF Biological Term Annotations	1.0	null
imipramine-1849	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SKA3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE255432_7_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
22RV1	CCLE Cell Line Gene Mutation Profiles	1.0	null
Perturb_11187_KO_Trp53/Gdown1_SRP244620	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.23913
TOMM20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57115
oxygen	Phosphosite Textmining Biological Term Annotations	1.0	null
Psoas_Muscle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	2.17009
Biotin carboxylation domain	InterPro Predicted Protein Domain Annotations	1.0	null
FAM175B	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-5644-01A-21R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HS742T	CCLE Cell Line Gene Mutation Profiles	1.0	null
central gray substance of midbrain, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.889624
lateral portion of the shell	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.953626
design	GeneRIF Biological Term Annotations	1.0	null
GTEX-XUZC-1126-SM-4BOPZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03881
BRD-K62459624_T5212475_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary motor cortex (area M1, area 4)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.52574
PPARA_KO_GDS3748_516_mouse_Livers	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE183251_1_v_5_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
acetyl-coa carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	2.78266
Subiculum, dorsal part, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21703
GSE174701_1_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
SW948	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE205730,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PPP4C	Pathway Commons Protein-Protein Interactions	1.0	null
pathology	Phosphosite Textmining Biological Term Annotations	1.0	null
A549_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147762
GSE174383_2_v_5_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975955
GSE139987_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
lymphoid tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052324
GSE199899_4_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE60691_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RTLS-0008-SM-48FET	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07393
CRCGN014_HEPG2_3H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08821
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Down_bins-Down_bins_loosing_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42336
pyruvate metabolism	KEGG Pathways	1.0	null
ABCA9	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K69580972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.51045
GSE210682_2_v_1_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
eukaryotic	Phosphosite Textmining Biological Term Annotations	1.0	null
7q11 23 copy number variation syndrome	WikiPathways Pathways 2024	1.0	null
GSE157594_6_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
WWP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87013
GSE147669_2_v_1_tram2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1763
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.569
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3116
BRD-A52193669_2816_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
PRKAA2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE217776,GSE217829_2_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.052464
chr12_109139930_C_T_b38	GTEx eQTL 2025	1.0	1.98248
SNX18	Pathway Commons Protein-Protein Interactions	1.0	null
phosphorylation	GeneRIF Biological Term Annotations	1.0	null
fat_a.V1	HPA Tissue Sample Gene Expression Profiles	1.0	1.62699
S100A7	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Nintedanib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015949
ventrolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.913698
cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-XBED-2326-SM-47JYR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60609
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-5641-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7000_KO_Acadl/Acadvl_SRP323582	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GSE196699_2_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WY7C-0926-SM-3NB34	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961106
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03535
MIA-PACA-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.22469
KYM1	CCLE Cell Line Gene Expression Profiles	1.0	1.88909
regulation of heart growth	GO Biological Process Annotations 2015	1.0	null
organelle outer membrane	GO Cellular Component Annotations 2015	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE193999,GSE194000_4_v_0_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-125a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
Lung adenocarcinoma_LUAD_TCGA-55-6981-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE221742,GSE221743_1_v_2_sipa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
lateral septal nucleus, intermediate part, periventricular	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6671
CD56+_NKCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.3515
RCOR3-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
layer 6 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.71222
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.321
EBC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MDAMB134VI	CCLE Cell Line Gene CNV Profiles	1.0	1.76894
NCI-H1623	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K25791914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7983
Anterolateral visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38436
GSE158632_2_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7305081-10120_2020_1045_MOESM1_ESM.xlsx-Tab2-Mutation-MAF_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
Glucagon signaling pathway	KEGG Pathways 2026	1.0	null
muscle fibre	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.603295
testis	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
chloroplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.964549
NFE2L2-20460467-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
nucleus of the stria medullaris (prethalamic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13158
hsa-miR-654-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
BRD-A39255369_DCPIB_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19618
BRD-K17140735_-666_SW948_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lipid	Phosphosite Textmining Biological Term Annotations	1.0	null
DU-145	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HS939-T	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE154940_1_v_0_nbdy_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
SHANK2	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.70058
eye cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.356686
MCF7_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0088169
GTEX-T5JC-0526-SM-32PM7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09018
collicular (rostral) midbrain tectum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06297
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.82352
GATA3-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN011_HEPG2_24H:I04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20712
Activation of gene expression by SREBF (SREBP)	Reactome Pathways 2014	1.0	null
Pancytopenia	CTD Gene-Disease Associations	1.0	1.23584
abdomen	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.107108
abnormal fatty acid oxidation	MPO Gene-Phenotype Associations	1.0	null
L-6 myoblast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.117
GSE183251_4_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26277
response to chemical	GO Biological Process Annotations 2015	1.0	null
FZR1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XPVG-0008-SM-4GICH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946714
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7238-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A67438293_10162_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4994-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.43423
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08855
H513	COSMIC Cell Line Gene Mutation Profiles	1.0	null
appear	GeneRIF Biological Term Annotations	1.0	null
decreased total body fat amount	MPO Gene-Phenotype Associations	1.0	null
GSE126402_4_v_7_tal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110268_1_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A9WJ-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A60245366_AS-601245_SKBR3_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K92349794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06584
BRD-A31227688_KYNURAMINE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-P4QS-0226-SM-3NB1U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05529
CEP192	Pathway Commons Protein-Protein Interactions	1.0	null
Nodulus (X)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.43574
Triglyceride levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.9
OSC-20	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22069
Glutamate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.827
GSE172189_0_v_1_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
anterior pretectal nucleus, ventral superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54985
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08633
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.07601
BRD-K38998073	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03452
TBX20-22080862-HEART-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K59049340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.468
GSE166004_5_v_6_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S4P3-1626-SM-3K2AZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05462
A549_Costunolide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145871
A549_A-366_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151103
BRD-K90693562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66503
SNU-283	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20Q-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRKAA2	KEA Substrates of Kinases	1.0	null
PMC9616467__F8	PFOCR Pathway Figure Associations 2024	1.0	null
site	GeneRIF Biological Term Annotations	1.0	null
acyl-CoA metabolic process	GO Biological Process Annotations 2025	1.0	null
BRD-K65250438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57211
GSE245134_2_v_3_atg5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Diabetes Mellitus, Experimental	CTD Gene-Disease Associations	1.0	1.20526
GSE130081,GSE130082_0_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.237
A704	CCLE Cell Line Gene CNV Profiles	-1.0	-2.19159
negative regulation of biological process	GO Biological Process Annotations 2015	1.0	null
GSE188870,GSE188871_4_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_18046_KO_Ocln_SRP304697	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.67097
CAPAN2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44963
ML-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K12867552_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
oxidation	GeneRIF Biological Term Annotations	1.0	null
proton-transporting ATP synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.043
Hand1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.839
BRD-K01691949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70107
SARC9371	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-4443	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
intermediate stratum of PThE	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13031
anterior hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0113
DEOC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
insulin	Phosphosite Textmining Biological Term Annotations	1.0	null
GSE219274,GSE219276_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TRAK1	Pathway Commons Protein-Protein Interactions	1.0	null
15297395-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
layer 3 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.89101
acetylcoa	GeneRIF Biological Term Annotations	1.0	null
CRCGN010_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61035
GSE157894_1_v_3_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
creb1_22108299_heart_left_ventricle_lof_mouse_gpl1261_gds3660	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.733365
NCI-H23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K86964464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56576
ELAVL1	Pathway Commons Protein-Protein Interactions	1.0	null
hippocampus (hippocampal formation)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.993095
b-cell lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.264353
skin	GTEx Tissue Gene Expression Profiles	-1.0	-0.84014
Adrenocortical carcinoma_ACC_TCGA-OR-A5JM-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE193751_1_v_3_oridonin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K65438558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00742
BACH1	ChEA Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7737-11A-02R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-7337-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
agtr1	GeneRIF Biological Term Annotations	1.0	null
Breast_Myoepithelial_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.19113
lipid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_42_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6879454-Data_Sheet_1.xlsx-AA_in_vitro-Unnamed_4_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
conferring	GeneRIF Biological Term Annotations	1.0	null
Cholestasis, Intrahepatic	CTD Gene-Disease Associations	1.0	1.4164
BRD-K44576681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27904
phosphatase	Phosphosite Textmining Biological Term Annotations	1.0	null
BRD-K49865102_PD-0325901_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-75-7025-01A-12R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EB2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC4732299__F5	PFOCR Pathway Figure Associations 2023	1.0	null
immunostaining	GeneRIF Biological Term Annotations	1.0	null
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.131
muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.51902
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053338
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6559
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF_Q1_vs_Q4-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
TK10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MEF2A_MEF2A	Rummagene Transcription Factor Associations 2026	1.0	null
CROCC	Pathway Commons Protein-Protein Interactions	1.0	null
GSE151612_4_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7300300__F3	PFOCR Pathway Figure Associations 2023	1.0	null
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12271601-mmc2.xlsx-OUT_cells_03-Gene_Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
EEF1A1	Pathway Commons Protein-Protein Interactions	1.0	null
multiform (lateral) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.38183
BRD-K64052750_gefitinib_HME1_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
protein-transport	Phosphosite Textmining Biological Term Annotations	1.0	null
RPL4	Pathway Commons Protein-Protein Interactions	1.0	null
TBL2	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4756-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-98-A53C-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE140651,GSE140653_2_v_6_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE240030,GSE252532_0_v_2_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Egg white	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.631
metrifonate-1797	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney Tubular Necrosis, Acute	CTD Gene-Disease Associations	1.0	1.32756
downregulation	GeneRIF Biological Term Annotations	1.0	null
Medial pretectal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26192
BRD-K23984367_sorafenib_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE217441,GSE217443_1_v_0_ivosidenib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TGBC11TKB	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE169152_3_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A52650764_Ingenol 3, 20-dibenzoate_HCC15_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K45631723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48148
tridihexethyl-5486	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K81288338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19035
Adipocytokine signaling pathway	KEGG Pathways 2026	1.0	null
BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
tiratricol-1412	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Gestational diabetes	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
AR	ChEA Transcription Factor Targets	1.0	null
hippocampus (hippocampal formation)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.984014
lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057307
TRRAP	Pathway Commons Protein-Protein Interactions	1.0	null
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.494528
BRD-K11636097_S1249_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.354
lipid biosynthetic process	GO Biological Process Annotations 2023	1.0	null
SUPT11	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64546
ABRA	Pathway Commons Protein-Protein Interactions	1.0	null
fatty-acyl-coa biosynthetic process	GO Biological Process Annotations 2015	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Agranular insular area, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14235
SIK2	Pathway Commons Protein-Protein Interactions	1.0	null
sulfacetamide-1859	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZFHX3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE196699_2_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MZ7-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K80622725_STK397047_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE148692,GSE148695_5_v_6_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K78659596_MLN2238_A673_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K36me3_Skeletal Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.49881
BRD-K37846922_GR-207_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K93268593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21416
increased glycogen level	MPO Gene-Phenotype Associations	1.0	null
GSE48812_4_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
IKKB	Kinase Library Serine Threonine Kinome Atlas	1.0	null
r6 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.89576
BRD-K06980535_PROMAZINE HYDROCHLORIDE_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOXD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2
MED12L	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K92241597_CHR 2797_A375_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
appendices_4b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.03999
A549_MK-5108_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0226736
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05362
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
NID1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2043
Coma	CTD Gene-Disease Associations	1.0	1.59101
effect	GeneRIF Biological Term Annotations	1.0	null
GTEX-QVJO-1826-SM-447C9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833364
nasopharynx	HPA Tissue Protein Expression Profiles	-1.0	-1.68434
PMC7220941-41598_2020_64431_MOESM2_ESM.xlsx-WS1_2019_Affy_IDs_RA-STvsOA-ST-Unnamed_2_PAX3	Rummagene Transcription Factor Associations 2026	1.0	null
increased skeletal muscle glycogen level	MPO Gene-Phenotype Associations	1.0	null
GSE152055_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12271601-mmc2.xlsx-OUT_cells_02-Gene_Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
TK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE202587_1_v_2_xrn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07387
hsa-miR-1280	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
BRD-A00267231_HEMADO_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-7658-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE205316,GSE205317_0_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KRT1	Pathway Commons Protein-Protein Interactions	1.0	null
(2S)-2-(4-{[3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]OXY}PHENOXY)PROPANOIC ACID	DrugBank Drug Targets	1.0	null
PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-ensembl_AR	Rummagene Transcription Factor Associations 2026	1.0	null
RC-K8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.58335
PSMC1	Pathway Commons Protein-Protein Interactions	1.0	null
abnormal emotion/affect behavior	GWASdb SNP-Phenotype Associations	1.0	0.267984
RVH-421	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ligase activity, forming carbon-carbon bonds	GO Molecular Function Annotations 2015	1.0	null
FOSL1	MSigDB Cancer Gene Co-expression Modules	1.0	null
PMC12658036-41598_2025_25964_MOESM5_ESM.xlsx-Sheet1-Supplementary_Table_1_The_list_of_546_proteins_specific_to_pLV3-CMV-AR-TurboID_H2O2_group_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Intrinsic component of mitochondrial outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.777
GSE207914_2_v_6_nudt7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
very-low-density lipoprotein particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.137
GSE231799_2_v_1_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7689163-mmc4.xlsx-Cluster3vs4-TP53_NS_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
Biliary tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
KLF1-20508144-FETAL-LIVER-ERYTHROID-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE178227_1_v_2_tet1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
increased circulating insulin level	MGI Mouse Phenotype Associations 2023	1.0	null
GSE248769_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K07431402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41119
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18019
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02076
BRD-K25737009_-666_MCF7_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ERBB2_knockdown_236_GSE8373	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.42143
mesocarp	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.703127
PMC7576810-41419_2020_3099_MOESM9_ESM.xlsx-MS_analysis_EVI1-WT_vs_EVI1-S43-Unnamed_0_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7783-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5629025-elife-27159-fig1-data1.xlsx-Direct_AR_target_genes-Control_only_down-regulated_genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MDAMB361	CCLE Cell Line Gene Mutation Profiles	1.0	null
cho	Phosphosite Textmining Biological Term Annotations	1.0	null
r1 part of vestibular nucleus Y	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36101
naproxen-1828	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_Tubastatin A HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143266
PRSS1	Pathway Commons Protein-Protein Interactions	1.0	null
Endometriosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
BRD-K61924932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45405
BRD-K90769476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72355
FANCA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0067921
carbarsone-1313	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.98672
hypocotyl	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.249653
GSE240386,GSE242143_1_v_5_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36461
molindone-2917	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE133927_1_v_3_meox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
isthmic portion of paranigral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04053
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63486
BRD-K43069600_12K-516S_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
foot	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.985425
Tcf21	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.8969
MCF7_Dasatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206976
BRD-K54790157_Trioxsalen_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.258
GTF2F1_02_110	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.63073
GTEX-RNOR-1326-SM-48FDE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.842534
oculomotor nucleus, Edinger-Westphal subnucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15517
NB1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.59447
HIRA	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K44432556_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE157383_3_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6835-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06262
BRD-K49328571_HY-10181_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-X4XX-0626-SM-3NMC1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.899869
VCAP	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.03822
BRD-K24156250_NCGC00182393-01_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE140651,GSE140653_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.054
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08902
HS578T	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.00942
GTEX-PLZ6-0008-SM-48TD5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33321
MAST4	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_10831_KO_Xbp1_SRP262377	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.30736
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08221
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.248
SEC11C	Pathway Commons Protein-Protein Interactions	1.0	null
fat	GeneRIF Biological Term Annotations	1.0	null
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
PMC3702532__F7	PFOCR Pathway Figure Associations 2023	1.0	null
Perturb_10805_KO_Xbp1_SRP197108	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.87988
GSE205316,GSE205317_2_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ion binding	GO Molecular Function Annotations 2015	1.0	null
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.920158
PPP6C	Pathway Commons Protein-Protein Interactions	1.0	null
SLC22A23	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00610637
PMC12549544-mmc2.xlsx-AA_D14_VS_D21-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE95077_5_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
heart	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Nephritis, Interstitial	CTD Gene-Disease Associations	1.0	1.47167
GSE169697,GSE169725_1_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ChIP_TBX3_20139965	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K74402642_Chemistry 2804_THP1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Carboxyl transferase	InterPro Predicted Protein Domain Annotations	1.0	null
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050536
sulfur compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GSE119603_1_v_0_oxaliplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cuneiform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.946346
GTEX-P4QR-0726-SM-2I5GO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31395
TAOK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520945
KP2	Achilles Cell Line Gene Essentiality Profiles	1.0	2.8069
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.964979
Liver Failure, Acute	CTD Gene-Disease Associations	1.0	1.60758
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.87987
BRD-K30993697_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
ATXN2L	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K13402127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42062
YWHAZ	Pathway Commons Protein-Protein Interactions	1.0	null
protein homotetramerization	GO Biological Process Annotations 2023	1.0	null
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.94796
AG-012559-6920	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CCT5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A58767537_afatinib_SKBR3_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE48812_4_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
KALRN	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A857-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pneumonia	CTD Gene-Disease Associations	1.0	1.22469
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16552
Acetyl-CoA carboxylase, central domain	InterPro Predicted Protein Domain Annotations	1.0	null
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.80862
PMC11474056-pnas.2404841121.sd01.xlsx-Supplemental_Table_8_Fig1G-H-Supplemental_Table_8_Transcriptomic_overlap_between_LPS_and_Sepsis_and_or_Tuberculosis_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
OPHN1	Pathway Commons Protein-Protein Interactions	1.0	null
increased skeletal muscle glycogen level	MGI Mouse Phenotype Associations 2023	1.0	null
SRRM2	Pathway Commons Protein-Protein Interactions	1.0	null
Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K74305673_IMD 0354_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PABPC1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49286
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S5-Table_S5_The_result_of_MR_analysis_and_sensitivity_analysis_for_FVC_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120413,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6499
SNX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33521
BRD-K55722623_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4337-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053581
FZR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90458
SYK_druginhibition_286_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.20533
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26957
GTEX-PLZ4-0226-SM-2S1NW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895165
Tonsil	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
MONOMAC6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67919
LY-294002-1180	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Human - Heart - L1 - Adipocyte	HuBMAP Azimuth Cell Type Annotations	1.0	null
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913189
BRD-K10707948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.40348
A431	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K67844266_MLN4924_HCC515_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE125403_7_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
A204	BioGPS Cell Line Gene Expression Profiles	1.0	0.941792
UKE-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.25891
brain cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076421
GSE84922,GSE84924_4_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE65617_0_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Liver Failure	CTD Gene-Disease Associations	1.0	1.17959
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00152
BRD-K28120222_Prestw-550_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE152050,GSE152052_1_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
nomegestrol-6525	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
induced	GeneRIF Biological Term Annotations	1.0	null
Cardiovascular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Adipose tissue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FXR	MotifMap Predicted Transcription Factor Targets	1.0	null
TMEM52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46607
periventricular stratum of r3Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02031
GTEX-OXRL-1626-SM-2YUMU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26671
homeostasis	Phosphosite Textmining Biological Term Annotations	1.0	null
ERBB2IP	Pathway Commons Protein-Protein Interactions	1.0	null
myoblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.822339
NCI-H1838	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE226114,GSE226116_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH1339	CCLE Cell Line Gene Mutation Profiles	1.0	null
CHRM5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00607633
regulation of developmental growth	GO Biological Process Annotations 2015	1.0	null
HS343T	CCLE Cell Line Gene Mutation Profiles	1.0	null
conclusion	GeneRIF Biological Term Annotations	1.0	null
N-phenylanthranilic acid-317	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Abdominal adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.921
AMPK signaling pathway	KEGG Pathways 2026	1.0	null
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.01327
SETX	Pathway Commons Protein-Protein Interactions	1.0	null
Epitrochlearis muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.804
Myoblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.621
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044094
GSE139239_2_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LXR-22158963-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
abnormal body fat mass	MPO Gene-Phenotype Associations	1.0	null
CREB1-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
RT4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07375
FBF1	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IR-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE131649_2_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE211357_1_v_3_atg7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
Renal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.838445
CCK81	DepMap CRISPR Gene Dependency	1.0	2.06255
anterior amygdaloid area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27366
SNU175	CCLE Cell Line Gene Mutation Profiles	1.0	null
BRD-K58347372_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SK23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.832966
PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-203_ChIP-Seq_H3K9me1_2_AR_differential_down_regulation_upon_KDM3A_knockdown_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12592558-41419_2025_8097_MOESM4_ESM.xlsx-downregulated_3_-_DATASET_1-RNA_Seq_analysis_upon_lncMB3_KD_in_D283_Med_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
DNAJB12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34757
Mitochondrial outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.896
GSE254155_5_v_0_per2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE108614,GSE108615_3_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
pheniramine-4130	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K67998155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.71896
BRD-K49328571_dasatinib_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE221577_3_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
fatty acid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GSE196699_4_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE102870_11_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K13672060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.064
GSE48812_9_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-O5YU-0008-SM-4E3I7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24535
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3482
A549_Alendronate sodium trihydrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0218123
GSE199644_3_v_2_palmitic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Thyroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.944474
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
carteolol-4176	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC8185197__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.309
BRD-K51662849_GM6001_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Cervix disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.248
GSE228263_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	1.0	null
MRPL19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15353
mitochondrial membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
posteroventral (inferior) parietal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16812
inorganic anion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
BL2671 (FANCB)	NURSA Protein Complexes	1.0	null
Dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47344
BRD-K38788176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09683
membrane	GO Cellular Component Annotations 2015	1.0	null
SAS	GDSC Cell Line Gene Expression Profiles	-1.0	-1.47998
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.402
GSE157282_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
more	GeneRIF Biological Term Annotations	1.0	null
MG63	CCLE Cell Line Gene Mutation Profiles	1.0	null
alzheimer's disease	GAD Gene-Disease Associations	1.0	null
Precancerous Conditions	CTD Gene-Disease Associations	1.0	2.0593
MCF7_Alvespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120963
SNU201	CCLE Cell Line Gene CNV Profiles	-1.0	-1.82183
PMC11882939-42003_2025_7842_MOESM2_ESM.pdf-16-KLF2_KLF2	Rummagene Transcription Factor Associations 2026	1.0	null
rats	GeneRIF Biological Term Annotations	1.0	null
Osteoporosis	HuGE Navigator Gene-Phenotype Associations	1.0	null
Ovarian dysfunction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
BRD-K37931645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50119
PMC12559107-12035_2025_5221_MOESM1_ESM.xlsx-Supplment_Tab_3-Supplement_Tab_3_The_result_of_MR_analysis_for_SCZ_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
regulation of developmental process	GO Biological Process Annotations 2015	1.0	null
differences	GeneRIF Biological Term Annotations	1.0	null
20220088-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
Hepatitis	CTD Gene-Disease Associations	1.0	1.96147
hsa-miR-4252	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
BRD-K50140147_HY-10192_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KYSE-520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.858287
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.783
Lung squamous cell carcinoma_LUSC_TCGA-33-4587-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCP10L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38787
Fatty acid, triacylglycerol, and ketone body metabolism	Reactome Pathways 2014	1.0	null
Paresthesia	CTD Gene-Disease Associations	1.0	1.18587
MOLM16	CCLE Cell Line Gene Expression Profiles	1.0	1.70938
GSE112760,GSE112767_2_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S1-Table_S1_Instrumental_variables_used_in_MR_analysis_of_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X4XY-0926-SM-4E3JD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99698
KMRC20	CCLE Cell Line Gene Mutation Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-51-4080-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K76521932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03956
alpha-subunit	Phosphosite Textmining Biological Term Annotations	1.0	null
inorganic cation transmembrane transport	GO Biological Process Annotations 2015	1.0	null
PMC6985208__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-WA-A7GZ-11A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7747-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SGC0946	DeepCoverMOA Drug Mechanisms of Action	1.0	0.57
fluspirilene-3086	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DDHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01061
GTEX-PLZ5-1826-SM-3NB22	GTEx Tissue Sample Gene Expression Profiles	1.0	0.972588
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
17470200-Table3	GeneSigDB Published Gene Signatures	1.0	null
BRD-K78373679_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE171837_0_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPS4X	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WOFM-1326-SM-3MJFR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06939
BRD-K78347804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04929
placenta_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.984044
fat_8a	HPA Tissue Sample Gene Expression Profiles	1.0	1.41241
DFCI024	CCLE Cell Line Gene Expression Profiles	1.0	1.84578
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCallEPC1-PHF1_H3K27me3_k562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K61220632_LEOIDIN DIMETHYL ETHER_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE196699_7_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hepatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.219
PMC10528072-NIHMS1928302-supplement-5.xlsx-NEUROD1-target_genes-AANAT_NEUROD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K45503385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38095
AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-UJHI-1726-SM-3DB9B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76597
macromolecular complex subunit organization	GO Biological Process Annotations 2015	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-A7CX-01A-12R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in postamygdaloid region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.916176
GSE125403_7_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prostatic Neoplasms	CTD Gene-Disease Associations	1.0	1.11081
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00158
BRD-K49328571_dasatinib_HA1E_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K88977610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04543
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5672-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
outer SZ in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.869698
GTEX-XQ8I-0526-SM-4BOPS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12241
Sympathetic nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.329
layer 6b of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.32663
Respiratory chain complex IV	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.163
TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_11094_KO_Regnase1_DRP004811	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Perturb_11333_KO_Bmal1_SRP060295	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.18985
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86561
MDAMB361	CCLE Cell Line Gene CNV Profiles	1.0	1.92877
MAGI1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC2927952__F3	PFOCR Pathway Figure Associations 2023	1.0	null
glial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081969
GTEX-WEY5-1926-SM-3GIL8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.25301
GSE104508_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
adenyl ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K82395301_ST4066738_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-2655-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K37285826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15439
Pancreatic alpha cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.122
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.027339
Perturb_10824_KO_Xbp1_SRP197108	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.46305
nitrogen compound transport	GO Biological Process Annotations 2015	1.0	null
GTEX-P78B-1626-SM-2S1O1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07195
PMC4619386__F6	PFOCR Pathway Figure Associations 2024	1.0	null
METFORMIN	DGIdb Drug Targets 2026	1.0	0.0816852
ISL1-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.031117
abnormal heart size	MPO Gene-Phenotype Associations	1.0	null
GSE112202_4_v_0_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Metabolic acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.191
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.989486
RCN2	Pathway Commons Protein-Protein Interactions	1.0	null
LGALS7B	Pathway Commons Protein-Protein Interactions	1.0	null
cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
TPH1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-7658-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE157594_5_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
plastid acetyl-coa carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.51412
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04608
GSE138050,GSE148257_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04967
PMC7895828-41419_2021_3488_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_3_List_of_deregulated_genes_in_c-MYC_altered_human_HCC_from_TCGA_LIHC_dataset_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
Disease Models, Animal	CTD Gene-Disease Associations	1.0	1.74721
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-S7SF-0008-SM-3NM8T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33744
fatty acid metabolic process	GO Biological Process Annotations 2025	1.0	null
thioridazine-5916	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Mitochondrial small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.622
tribenoside-2946	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.437
brain	GTEx Tissue Gene Expression Profiles	-1.0	-0.961927
RALGAPA1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE202434,GSE202438_9_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Morbid obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.431
chlorphenamine-2217	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Adenocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PWR-1E	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K64730221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34673
DYNLRB1	Pathway Commons Protein-Protein Interactions	1.0	null
nucleobase-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
SW 1990	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.964204
BRD-K78939372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0798
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05555
GSE124410_3_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51268
Hyperinsulinism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.806
stomach	HPA Tissue Protein Expression Profiles	1.0	1.16855
acetyl-CoA carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.689
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.75
energy reserve metabolic process	GO Biological Process Annotations 2015	1.0	null
Lactic acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.165
small heart	MPO Gene-Phenotype Associations	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.96372
r3 liminal central gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01949
GSE181461_1_v_4_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4875
Endocrine pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.714
GTEX-WEY5-1326-SM-3GILS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57256
GSE197850_4_v_2_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_1_v_3_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K68548958_-666_SKMEL28_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39536
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01422
HCC1954	CCLE Cell Line Gene Mutation Profiles	1.0	null
DCD	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9595552__F4	PFOCR Pathway Figure Associations 2024	1.0	null
PF-05175157	DGIdb Drug Targets 2026	1.0	3.30825
lipid particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.269701
Postsubiculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42545
BRD-K13941052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1328
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.018
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.93534
BAHCC1	Pathway Commons Protein-Protein Interactions	1.0	null
r9 part of trigeminal transition zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32315
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	1.89634
Cardiomyopathies	CTD Gene-Disease Associations	1.0	1.62423
GCT	DepMap CRISPR Gene Dependency	1.0	2.01332
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormal behavior	MPO Gene-Phenotype Associations	1.0	null
GSE210101,GSE210114_7_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K98548675_Parthenolide_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RPS8	Pathway Commons Protein-Protein Interactions	1.0	null
basolateral nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.63564
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.74365
NEC8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Myocarditis	CTD Gene-Disease Associations	1.0	1.19345
BRD-K31437957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41405
GTEX-PSDG-0008-SM-48TE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23325
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10194
BRD-K20203758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3381
THRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.6648
superficial stratum of PcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.03299
support	GeneRIF Biological Term Annotations	1.0	null
KCI-MOH1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00036
BFTC909	CCLE Cell Line Gene Mutation Profiles	1.0	null
xylometazoline-2270	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K56837922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94867
GTEX-XPVG-2726-SM-4B66W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.96043
GTEX-TKQ1-1126-SM-4GIAZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61007
HIST1H1E	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K67902591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45694
PMC7875919__F2	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K82805160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14979
SKMEL1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48435
novobiocin-4392	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
amp-activated	Phosphosite Textmining Biological Term Annotations	1.0	null
IL1B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PLZ4-0926-SM-2S1OI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.893788
receptors	Phosphosite Textmining Biological Term Annotations	1.0	null
Organelle outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.899
Phosphate	HMDB Metabolites of Enzymes	1.0	null
Neutropenia	CTD Gene-Disease Associations	1.0	1.22145
NCI-H2596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.905257
Anxiety Disorders	CTD Gene-Disease Associations	1.0	1.62246
nucleus	GO Cellular Component Annotations 2023	1.0	null
Perturb_10714_KO_Foxo1_SRP375712	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.96771
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.549
Myocardial Infarction	CTD Gene-Disease Associations	1.0	2.00178
BRD-A06276885_N-Benzylnaltrindole hydrochloride_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Diabetes	DisGeNET Gene-Disease Associations	1.0	null
synthesis	GeneRIF Biological Term Annotations	1.0	null
PMC8530322-pone.0258316.s002.xlsx-GG_776_no-AA_776_no-Symbol_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BATF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00593045
Metabolism of vitamins and cofactors	Reactome Pathways 2024	1.0	null
organic acid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.677
HS822T	CCLE Cell Line Gene Mutation Profiles	1.0	null
GTEX-QXCU-0008-SM-48FCH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24474
PPARA_agonist activation_GSE17250_475_mouse_Isolated hepatocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
rs2268388	GeneRIF Biological Term Annotations	1.0	null
TCF7-22412390-EML-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
ABCB1	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Injuries	CTD Gene-Disease Associations	1.0	1.23993
A549_G007-LK_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140525
GTEX-WFJO-0008-SM-4LVN7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913939
hsa-miR-483-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.944572
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.86
14768006-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.967813
MZ in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.46422
A549_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148126
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.546
GTEX-O5YT-1626-SM-32PK6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16758
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.52
SNU719	CCLE Cell Line Gene Mutation Profiles	1.0	null
ocular cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.174881
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944614
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.46173
hepatoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.240216
endocrine pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.106314
GTEX-T5JW-0008-SM-4DM5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07576
tonsil_8a1	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.904686
15721472-76genes	GeneSigDB Published Gene Signatures	1.0	null
MRPL14	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_2545_KD_BRD4_SRP040136	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Hepatic Encephalopathy	CTD Gene-Disease Associations	1.0	1.17662
promoter	GeneRIF Biological Term Annotations	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.22226
Liver cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.053
Non-alcoholic Fatty Liver Disease	CTD Gene-Disease Associations	1.0	1.73557
liver	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.981084
PCCB	Pathway Commons Protein-Protein Interactions	1.0	null
PMC8725436-12864_2021_8226_MOESM4_ESM.xlsx-Sheet0-Table_S2_Target_molecules_of_XBP1_and_their_directional_changes_in_the_RNAseq_dataset_from_fasted_vs_12hrpf_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
r5 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20991
EBC1	CCLE Cell Line Gene CNV Profiles	1.0	2.08885
NUP98	Pathway Commons Protein-Protein Interactions	1.0	null
PMC2943625-supp_gkq287_SupplResults.xls-AR_mod_cand_and_targets-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44O-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12069319-Table1.xlsx-OCAB_p40_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
Organelle inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.902
NCI-SNU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MONOMAC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.78233
Acetolactate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.974
increased circulating ketone body level	MGI Mouse Phenotype Associations 2023	1.0	null
SYK_druginhibition_153_GSE34176	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.63207
PMC3639322__F3a	PFOCR Pathway Figure Associations 2024	1.0	null
KIAA0922	Pathway Commons Protein-Protein Interactions	1.0	null
GSE197564,GSE198513_2_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K58941403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19303
PMC8277837__F5	PFOCR Pathway Figure Associations 2024	1.0	null
Abdominal Pain	CTD Gene-Disease Associations	1.0	1.11945
BRD-K74305673_IMD 0354_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HT-55	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.238706
Lung squamous cell carcinoma_LUSC_TCGA-22-5472-11A-11R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VIM	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K29614616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04277
BRD-K63716942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.39698
proliferator-activated	Phosphosite Textmining Biological Term Annotations	1.0	null
Perinuclear region of cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.704
nucleus of the inferior collicular brachium, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.78415
Respiratory chain complex II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.444
GTEX-WYJK-1426-SM-3NM8V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4183
Liver cirrhosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.622
BRD-K29506255_NCGC00185087-01_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
heart	GeneRIF Biological Term Annotations	1.0	null
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.3505
GSE62843,GSE64370_0_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Paraflocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02154
PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
mist1_22510200_pancreas_c57bl6_lof_mouse_gpl6246_gds4341	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.175346
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.46153
BRD-K32176914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59028
precommissural nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.46155
GSE133213_6_v_15_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GLUL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00642029
PFDN2	Pathway Commons Protein-Protein Interactions	1.0	null
periventricular stratum of APal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67484
BRD-K10638173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16962
BRD-K04623885_BIBR1532_HEPG2_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RERF-GC-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.23546
TEX2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K28360340_TW 37_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7091-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14701_KO_TET1/TET2/TET3_SRP251780	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ANLN	Pathway Commons Protein-Protein Interactions	1.0	null
Bile	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.731
KE97	CCLE Cell Line Gene CNV Profiles	1.0	1.44769
layer IIIu of area 35r	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.76369
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
primary motor cortex (area M1, area 4)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.832824
hsa-miR-4639-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GTEX-WFG7-0926-SM-4LMK7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870112
GSE131161_1_v_0_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UO31	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.19392
BRD-K42918627_GSK-2126458_HME1_3_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K46348476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63874
Microcephaly	CTD Gene-Disease Associations	1.0	1.04611
CEBPG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1334
GSE223241_1_v_3_cdkn2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00125
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A0YR-11A-13R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IGR-1	GDSC Cell Line Gene Expression Profiles	1.0	1.64119
abnormal homeostasis	MPO Gene-Phenotype Associations	1.0	null
SW-1222 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.585
glioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.143741
hydrastine hydrochloride-1740	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
fatty acid metabolic process	GO Biological Process Annotations 2023	1.0	null
GTEX-XYKS-2426-SM-4AT43	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950932
saquinavir-6127	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TMEM33	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0064787
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
PMC6119347__F2	PFOCR Pathway Figure Associations 2023	1.0	null
23132-87	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Thigh muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.616
Lung adenocarcinoma_LUAD_TCGA-44-6148-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100457_TCx_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04736
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01846
tonsil_8b1	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.1652
18537972-TableS2	GeneSigDB Published Gene Signatures	1.0	null
A549_Tucidinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150993
BRD-K56957086_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ATP-grasp fold	InterPro Predicted Protein Domain Annotations	1.0	null
YWHAH	Pathway Commons Protein-Protein Interactions	1.0	null
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
MYC-20876797-MEDULLOBLASTOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
parvocellular part of the r9LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40834
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89216
BRD-A31204924_MITOTANE_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
layer 5 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.06697
midbrain reticular formation, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05976
level	GeneRIF Biological Term Annotations	1.0	null
KIF12	Pathway Commons Protein-Protein Interactions	1.0	null
C2C12 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.421
FOXO1::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6889
GSE244072_10_v_9_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HSF1	ChEA Transcription Factor Targets	1.0	null
tamoxifen_homo sapiens_gpl3921_gse33366	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K17140735_-666_SW620_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77909
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835831
MFE296	DepMap CRISPR Gene Dependency	1.0	3.63378
(-)-atenolol-3067	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ST6GALNAC6	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-O5YV-0226-SM-48TBY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49533
RUNX2-24764292-MC3T3-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-R55G-0008-SM-48FEX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03425
Olig2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.8727
MM1S	DepMap CRISPR Gene Dependency	1.0	2.47253
Lung squamous cell carcinoma_LUSC_TCGA-56-8083-11A-01R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Givinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137472
Perturb_17546_KD_STAT3_SRP354633	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Capecitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208231
GTEX-QVJO-0008-SM-447AU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.976231
hsa-miR-4304	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
ARHGEF2	Pathway Commons Protein-Protein Interactions	1.0	null
fatty-acyl-coa metabolic process	GO Biological Process Annotations 2015	1.0	null
Glucose	dbGAP Gene-Trait Associations	1.0	0.116644
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A4ZT-11A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GLI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00586729
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7245-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RUNX1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
RMUGS	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.02276
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XK95-0008-SM-4AT5G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851395
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EL-11A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAB11FIP5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K67439147_SIB 1893_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC4416014-pone.0125585.s010.xls-d_-BNC_network-Interactor_B_BNC1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.901692
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79058
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A6MF-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9170821-JCMM-26-3183-s001.xlsx-Neu_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_9_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27me3_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
18801183-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.503
BRD-K86467057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65344
abnormal cardiovascular system morphology	MPO Gene-Phenotype Associations	1.0	null
GSE139455_4_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18271
RCH-ACV	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LILRA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00585025
KYSE-150	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.52917
Perturb_6703_OE_Sema3d_SRP368076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.9607
Prostate adenocarcinoma_PRAD_TCGA-H9-A6BX-01A-31R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K75243062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70466
RL95-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
F36P	DepMap CRISPR Gene Dependency	1.0	2.54758
GSE196699_4_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S7PM-0008-SM-3NM9Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.02832
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05323
NCI-H650	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84478
GSE189609_1_v_0_hax1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Insulin Sensitivity	DisGeNET Gene-Phenotype Associations	1.0	null
Insulin Resistance	HuGE Navigator Gene-Phenotype Associations	1.0	null
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.246
GSE48812_7_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K17753780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8909
BRD-K63665694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39042
NFE2L2-20460467-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Kidney failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.419
GSE171177,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ATP5C1	Pathway Commons Protein-Protein Interactions	1.0	null
MTMR3	Pathway Commons Protein-Protein Interactions	1.0	null
19061838-TableS3	GeneSigDB Published Gene Signatures	1.0	null
cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Subcutaneous adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.713
Kidney renal clear cell carcinoma_KIRC_TCGA-AS-3777-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Arthritis, Experimental	CTD Gene-Disease Associations	1.0	1.35098
DMS273	CCLE Cell Line Gene Mutation Profiles	1.0	null
PMC9038526-mmc1.xlsx-healthy_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PSDG-0426-SM-2S1OF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24301
HEPA 1-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.088
BRD-K19540840_saracatinib_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AHNAK2	Pathway Commons Protein-Protein Interactions	1.0	null
abnormal adipose tissue morphology	MPO Gene-Phenotype Associations	1.0	null
GSE94849_6_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
External cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38647
trimipramine-4163	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MLX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1692
Pre-Eclampsia	CTD Gene-Disease Associations	1.0	1.0189
decreased circulating leptin level	MPO Gene-Phenotype Associations	1.0	null
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7888
BRD-A67788537_Salermide_MCF7_24.0_h_120.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
proinflammatory	GeneRIF Biological Term Annotations	1.0	null
Perturb_11101_KO_Ern1_SRP110147	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.55068
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.04623
decreased total tissue mass	MPO Gene-Phenotype Associations	1.0	null
BRD-K76908866_CP-724714_SKBR3_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
improvement	GeneRIF Biological Term Annotations	1.0	null
integument phenotype	MPO Gene-Phenotype Associations	1.0	null
GSE125862_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
rectum	HPA Tissue Protein Expression Profiles	1.0	1.16855
CRCGN015_HEPG2_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.95347
BRD-K28296557_Akt inhibitor IV_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
heptaminol-6015	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
retinal cell cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.178126
basolateral amygdaloid nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08212
GSE140937,GSE140938_1_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.25
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10733
Dyslipidemias	CTD Gene-Disease Associations	1.0	1.93137
energy derivation by oxidation of organic compounds	GO Biological Process Annotations 2015	1.0	null
PPA2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE240027,GSE240030_5_v_0_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.894
GTEX-T5JW-1826-SM-3GAE1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41624
Sarcoma_SARC_TCGA-MO-A47P-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XBEC-0008-SM-4AT3X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12863
BRD-K17232330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35343
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.924516
BRD-A40431293_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K61463582_GR-239_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.496
PPAR	MotifMap Predicted Transcription Factor Targets	1.0	null
Perturb_6217_KO_Mef2d_SRP227204	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	16.5754
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.58593
BRD-K09854848_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE230744,GSE237803_5_v_3_hira_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K21680192_mitoxantrone_HCC515_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Egg yolk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.83
cation binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K78003637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72221
nomegestrol-5461	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Insulin Resistance	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-OHPN-0226-SM-48TBV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12674
Lung adenocarcinoma_LUAD_TCGA-91-6849-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K69932463_AZD8055_HT115_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE86507,GSE86509_0_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216273,GSE216292_14_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MDAMB453	CCLE Cell Line Gene Mutation Profiles	1.0	null
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.35966
DNPEP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90326
BRD-K77718491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63672
Polycystic ovary syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.087
GTEX-O5YW-0008-SM-4E3IE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873989
BRD-K85493820_KM 00927_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K86574132_-666_MCF7_24.0_h_48.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OVCA 420	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.67208
blood cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055945
SLC35B4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58379
CNOT4	Pathway Commons Protein-Protein Interactions	1.0	null
ECC10	CCLE Cell Line Gene CNV Profiles	-1.0	-1.62419
minocycline-2405	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07387
decreased subcutaneous adipose tissue amount	MPO Gene-Phenotype Associations	1.0	null
GSE232223_1_v_0_letmd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5555
Rectum adenocarcinoma_READ_TCGA-AG-3742-11A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
decreased circulating glucose level	MGI Mouse Phenotype Associations 2023	1.0	null
altered	GeneRIF Biological Term Annotations	1.0	null
Glucose intolerance	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.916
NCI-H1435	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HNRNPC	Pathway Commons Protein-Protein Interactions	1.0	null
placenta_3a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.07832
GTEX-WYJK-1726-SM-3NM9U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18476
dorsolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.43265
pizotifen-3134	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE148263_6_v_0_trim3_human	RummaGEO Gene Perturbation Signatures	1.0	null
aclarubicin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25755
NOTCH2	Pathway Commons Protein-Protein Interactions	1.0	null
Defective HLCS causes multiple carboxylase deficiency	Reactome Pathways 2014	1.0	null
NRF2-20460467-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K12343256_trametinib_HS578T_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5866
RPS9	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
tranylcypromine-2264	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
leaf epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.590437
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09049
PANC-03-27	GDSC Cell Line Gene Expression Profiles	-1.0	-2.84282
lateral habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.58746
BRD-K98545272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66737
RNF138	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13865
KCI-MOH1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.53055
Central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.205
BRD-K63803358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02112
A549_MC1568_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157407
A549_MC1568_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014498
Brain Lower Grade Glioma_LGG_TCGA-HT-7680-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Thyroid gland disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.194
MYC	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.94261
MOLT-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-7138-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mitochondrial outer membrane	GO Cellular Component Annotations 2023	1.0	null
type	GeneRIF Biological Term Annotations	1.0	null
Microbody	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.29
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	3.06081
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IL-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
proximal	GeneRIF Biological Term Annotations	1.0	null
dilazep-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.25417
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39704
BRD-K72687327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71275
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050311
BRD-K54456668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22647
YWHAE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1219
GSE48812_0_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Dizziness	CTD Gene-Disease Associations	1.0	1.12117
KDM5A	ENCODE Transcription Factor Targets	1.0	null
psych	GAD High Level Gene-Disease Associations	1.0	0.293278
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.502
GSE111247_2_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZC3H18	Pathway Commons Protein-Protein Interactions	1.0	null
Medial amygdalar nucleus, posterodorsal part, sublayer c	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28201
GTEX-R55D-0826-SM-48FEA	GTEx Tissue Sample Gene Expression Profiles	1.0	2.3062
ChaGo-K-1	GDSC Cell Line Gene Expression Profiles	1.0	2.16481
HSP90AA1	Pathway Commons Protein-Protein Interactions	1.0	null
raubasine-2898	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bed nucleus of the anterior commissure	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14015
GSE213588_10_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE180200,GSE180201_2_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-623	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GSE174383_2_v_7_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LN235	Achilles Cell Line Gene Essentiality Profiles	1.0	1.24578
globus pallidus, external segment, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.36954
multienzyme-complexes	Phosphosite Textmining Biological Term Annotations	1.0	null
PLIN5_OE_GSE44192_482_mouse_heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7580-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11732233-mmc1.pdf-396-NFIB_NFIB	Rummagene Transcription Factor Associations 2026	1.0	null
globus pallidus, internal segment, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.47203
Defects in cobalamin (B12) metabolism	Reactome Pathways 2014	1.0	null
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.976417
t60-adrenal_male_1w	MoTrPAC Rat Endurance Exercise Training	1.0	1.55359
albendazole-oxide	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15349
PMC7064337-elife-51373-supp1.xlsx-MTF2_targets_shCTR-List_of_2011_genes_marked_by_MTF2_ChIPseq_in_control_conditions_shCTR_MTF2	Rummagene Transcription Factor Associations 2026	1.0	null
corynanthine-4811	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.910984
FGF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64742
tissues	GeneRIF Biological Term Annotations	1.0	null
GTEX-W5WG-1926-SM-4KKZK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23265
LYL1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Holocarboxylase synthetase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.485
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6933-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050857
abnormal triglyceride level	MPO Gene-Phenotype Associations	1.0	null
Perturb_10909_KD_Eif3m_SRP157047	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-12.2398
Sarcoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.333
Promyelocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.593
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33688
monorden-544	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K41652870_MLS-0435555.0001_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DSTYK	Kinase Library Serine Threonine Kinome Atlas	1.0	null
GSE149880_2_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC3728595-srep02327-s1.pdf-1622-IRF3_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12405457-41467_2025_63629_MOESM3_ESM.xlsx-Gene_Pair_List_LOC-HIC1_HIC1	Rummagene Transcription Factor Associations 2026	1.0	null
SDF4	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6214187__F1	PFOCR Pathway Figure Associations 2024	1.0	null
CFL1	Pathway Commons Protein-Protein Interactions	1.0	null
ZMIZ1_02_181	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60666
PCSK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19616
GSE146612_1_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.232
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.409
Defective MUT causes methylmalonic aciduria mut type	Reactome Pathways 2014	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CK-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mantle zone of CoPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08339
CMK	CCLE Cell Line Gene Mutation Profiles	1.0	null
unlike	GeneRIF Biological Term Annotations	1.0	null
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K25097691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52294
GSE214596,GSE214598_1_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
anterior nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.981083
ALPK3	Pathway Commons Protein-Protein Interactions	1.0	null
Dihydrolipoyl dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.343
superficial stratum of CoPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.03201
GTEX-XV7Q-2926-SM-4BRUL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90158
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.406
tridihexethyl-3526	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
oxidative	GeneRIF Biological Term Annotations	1.0	null
NOMO2	Pathway Commons Protein-Protein Interactions	1.0	null
cardiovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.615377
BRD-K44908610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20836
GSE146074_0_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XBEW-0008-SM-4AT3Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.91312
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TNFRSF18	Pathway Commons Protein-Protein Interactions	1.0	null
a94	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.597
GTEX-O5YT-0226-SM-32PK5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.16173
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211983_0_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04708
ornidazole-2272	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
y-79 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.455284
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.20513
BRD-K45245001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61664
SNU1077	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52496
GIGYF1	Pathway Commons Protein-Protein Interactions	1.0	null
klf4_17017123_rko_gof_human_gpl96_gds1942	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.1463
GRK7	Kinase Library Serine Threonine Kinome Atlas	1.0	null
lipid transport	GO Biological Process Annotations 2015	1.0	null
placenta	HPA Tissue Gene Expression Profiles	-1.0	-1.5114
ARID5B	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7178-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.061
NPTX2	Pathway Commons Protein-Protein Interactions	1.0	null
3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.106
gas gangrene	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.515725
BRD-K94325918_-666_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TSE9-0526-SM-3DB7Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02102
BRD-A65550283_ginsenoside-Rc_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cerebral lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
YWHAE	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_472_KD_ARAF_SRP259289	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.26905
piretanide-6144	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
atp	Phosphosite Textmining Biological Term Annotations	1.0	null
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.43418
elevated	GeneRIF Biological Term Annotations	1.0	null
GSE221327_6_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pulmonary Edema	CTD Gene-Disease Associations	1.0	1.62691
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03435
BRD-K03109492_NSC 663284_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K83935370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28076
BRD-K97493608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07466
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K54132860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06929
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055091
BRD-K29802952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41879
ribose phosphate metabolic process	GO Biological Process Annotations 2015	1.0	null
HDAC6_KO_GDS4375_372_mouse_CD4+CD25+ T-regulatory cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SNU-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14866
GSE231648_1_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WXYG-2226-SM-4E3IM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919377
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OBSCN	Pathway Commons Protein-Protein Interactions	1.0	null
GSE180185_7_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_10720_KO_Setd2_SRP220107	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.54904
GSE196699_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.647367
MRPS33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1366
RD_SOFT_TISSUE	CCLE Cell Line Proteomics	1.0	4.11951
CAPZA1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988788
BRD-K04695511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.50367
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7097-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-6143-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TKQ1-0008-SM-4DXSO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54042
CRCGN009_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.35385
PMC8755441-mmc3.xlsx-IRF1-UP-Symbol_IRF1	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.35838
2-[4-(2,4-Dichlorophenoxy)Phenoxy]Propanoic Acid	DrugBank Drug Targets	1.0	null
HSPD1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T6MO-1726-SM-33HB8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.28593
A549_Hesperadin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179413
mesophyll	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.844545
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.625
female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
MCCC2	Pathway Commons Protein-Protein Interactions	1.0	null
Primary somatosensory area, mouth, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1235
abnormal cellular respiration	MPO Gene-Phenotype Associations	1.0	null
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.19479
posteroventral (inferior) parietal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.56275
Perturb_8478_KO_PTPN2_SRP077320	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.335
pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.090763
LAMA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12735
disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041284
PMC10944835-41467_2024_46639_MOESM4_ESM.xlsx-SD17-Supplementary_Data_17_Differentially_expressed_genes_according_to_homozygous_genotype_at_the_TWIST1_locus_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEx Brain 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	13.5215
PMC8144624-41598_2021_90212_MOESM2_ESM.xlsx-3_hrs_ps_LPS-merged_Gene_ID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Lipid droplet	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.333
A549_Raltitrexed_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164876
Pediatric Obesity	DisGeNET Gene-Disease Associations	1.0	null
LB996-RCC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Bed nuclei of the stria terminalis, anterior division, ventral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42329
NCI-H2461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.861896
H2731	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE231648_1_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdaloid complex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.882056
Adipocyte	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
GSE243491_1_v_2_oxaliplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_PFI-1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144687
HK1	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.850206
KYSE-510	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
LIVF001-012	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24006
GTEX-S4Q7-1126-SM-4AD6R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81627
GSE142210_3_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE153867_6_v_3_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KRT32	Pathway Commons Protein-Protein Interactions	1.0	null
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
globus pallidus, internal segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.35371
NCBP2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE104604_1_v_0_eif5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Phosphorylase kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.861
GSE184356_1_v_2_tfam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
biosynthesis	Phosphosite Textmining Biological Term Annotations	1.0	null
hsa-miR-324-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GSE96641_5_v_0_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Barasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164019
Triangular nucleus of septum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.49267
GSE173873_8_v_11_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-421_ChIP-Seq_H3K9me1_2_AR_differential_expression_upon_KDM3A_or_AR_knockdown_AR	Rummagene Transcription Factor Associations 2026	1.0	null
G112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00152
BRD-K75688032	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.22817
KRT14	Pathway Commons Protein-Protein Interactions	1.0	null
RNF225	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38831
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.992257
GSE244710_3_v_0_srsf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Oily fish consumption	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.61549
forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052804
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K38929571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09593
hsa-miR-532-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
MCF7_Tanespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00938342
Respiratory Tract Infections	CTD Gene-Disease Associations	1.0	1.4633
BRD-K41731458_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE137653_4_v_0_siglecf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-P78B-0008-SM-48TE1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10753
Myocardial Infarction	DisGeNET Gene-Disease Associations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A83J-11A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0225
GSE123943_2_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8410083-elife-65574-fig7-data1.xlsx-KLF10_network-Genes_bound_by_KLF10_in_their_-10_1kb_region_or_differentially_expressed_in_WT_vs_HepKO_hepatocytes_challenged_with_high_sugar_KLF10	Rummagene Transcription Factor Associations 2026	1.0	null
GSE234340_10_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Rhabdomyolysis	CTD Gene-Disease Associations	1.0	1.23648
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70R-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SKMEL1	CCLE Cell Line Gene Mutation Profiles	1.0	null
MIB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.672
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05799
A549_Andarine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144494
isoetarine-5812	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_Azacitidine_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.00865807
NCIH441	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.01184
GSE248045,GSE248046_4_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PSDG-0326-SM-48TCP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895707
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.840972
GSE217776,GSE217829_1_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203181_0_v_1_phosphoramidon_human	RummaGEO Drug Perturbation Signatures	1.0	null
TMCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15848
embryonic fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.088027
biotin-3289	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC9267148__F6	PFOCR Pathway Figure Associations 2024	1.0	null
Rectum adenocarcinoma_READ_TCGA-AG-3732-11A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ser221	GeneRIF Biological Term Annotations	1.0	null
active	GeneRIF Biological Term Annotations	1.0	null
Organellar ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.132
MELHO	CCLE Cell Line Gene Expression Profiles	1.0	1.54464
SG in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28389
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38529
GSE60691_2_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3702532__F7	PFOCR Pathway Figure Associations 2024	1.0	null
Carcass	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.377
mantle zone of APal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5204
GSE217541,GSE217543_0_v_1_tet1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.96195
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.528
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.43315
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.911605
GSE197686,GSE197688_2_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P44H-0326-SM-2XCES	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29902
GSE123502,GSE123504_1_v_0_chd4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal energy expenditure	MGI Mouse Phenotype Associations 2023	1.0	null
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.58398
BRD-K93819193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00684
SCH	DepMap CRISPR Gene Dependency	1.0	4.09132
hsa-miR-548q	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
methylmalonic acidemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.458996
AICA ribonucleotide	CTD Gene-Chemical Interactions	1.0	null
otitis media	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.222479
CW2	CCLE Cell Line Gene Mutation Profiles	1.0	null
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.99444
OLUMACOSTAT GLASARETIL	DGIdb Drug Targets 2026	1.0	2.2055
SNUC1	DepMap CRISPR Gene Dependency	1.0	5.00461
COR-L26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05885
liver	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K15108141_gemcitabine_HCC515_6.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
damage	Phosphosite Textmining Biological Term Annotations	1.0	null
Anterior olfactory nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05253
Chloroplast outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.598
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.736014
Cardiomyoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.669
cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.912045
Mitochondrial envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
bipolar affective disorder	GWASdb SNP-Phenotype Associations	1.0	0.486693
superficial stratum of r9Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.89838
Mitochondrial respiratory chain complex I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.756
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A6QY-01A-12R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hyperinsulinism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.17952
143B	CCLE Cell Line Gene Expression Profiles	-1.0	-1.74726
Perturb_10844_KO_Xbp1_SRP262377	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.0142
CALY	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00578793
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.283
AKT1_OE_GDS2308_499_mouse_heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
NCI-H2106	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.08685
PPP1R9A	Pathway Commons Protein-Protein Interactions	1.0	null
paracentral lobule, anterior part, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.893629
Periventricular region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00168
esculetin-3120	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
gracile nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.993578
GPR158	Pathway Commons Protein-Protein Interactions	1.0	null
ATRIP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00606087
Lung adenocarcinoma_LUAD_TCGA-55-6980-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.411
Perturb_11162_KO_SREBP1c_SRP111134	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.435
Perturb_11133_KO_Hdac3_SRP082562	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
IZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05546
BRD-A24054354_-666_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ammonium transmembrane transport	GO Biological Process Annotations 2015	1.0	null
Perturb_9552_KO_Akt2_SRP101985	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.14359
mRNA_ZSCAN4C_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
nucleoside metabolic process	GO Biological Process Annotations 2015	1.0	null
ZSCAN16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03765
purine-containing compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Perturb_5532_KO_Hur_SRP174218	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
HPBALL	CCLE Cell Line Gene Mutation Profiles	1.0	null
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.892161
TUBB6	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_11186_KO_Gdown1_SRP244620	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.59067
CDK5RAP2	Pathway Commons Protein-Protein Interactions	1.0	null
MKL1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K02708799_GSK-1059615_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Mitochondrial creatine kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.855
PTTG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47744
GSE198254_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Gandotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171249
GSE157282_0_v_3_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H1_BMP4_Derived_Trophoblast_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.948938
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.22
commissural pretectal domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0344
organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
SMYD4	Pathway Commons Protein-Protein Interactions	1.0	null
griseofulvin-3664	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pallidal amygdala	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51912
QPCTL	Pathway Commons Protein-Protein Interactions	1.0	null
Adrenocortical carcinoma_ACC_TCGA-PK-A5H9-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of JcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.82696
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.74599
MIR122_Antisense Inhibition_GDS1729_759_mouse_Livers (from C57BL/6 adult males)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Metabolic Syndrome X	HuGE Navigator Gene-Phenotype Associations	1.0	null
MCF7_SB431542_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149968
GSE137818_3_v_7_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
germ plasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.168349
Insulin resistance	KEGG Pathways 2026	1.0	null
BRD-A55913614_PRIMAQUINE DIPHOSPHATE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intracellular transport	GO Biological Process Annotations 2015	1.0	null
GSE182680,GSE182683_5_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
SKLU1	CCLE Cell Line Gene CNV Profiles	1.0	1.57977
GTEX-QV31-1426-SM-2S1QD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11367
Pork consumption	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.61549
GTEX-U4B1-1626-SM-3DB8N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46684
GSE223241_2_v_0_cdkn2a_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22341
786O	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.05539
NALM-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K35559145_Methotrimeprazine maleat salt_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE137325_2_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
structures	GeneRIF Biological Term Annotations	1.0	null
DDX21	Pathway Commons Protein-Protein Interactions	1.0	null
BL480 (UBE3A)	NURSA Protein Complexes	1.0	null
Locus ceruleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19044
SmoothMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.919593
nucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.213322
BRD-K63030320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32322
Psychotic Disorders	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K02526760_QS 11_PL21_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RPS11	Pathway Commons Protein-Protein Interactions	1.0	null
ELMSAN1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE159937_1_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5577301-in-17-237-s001.xls-AR_downregulated_DEGs-Heart_GSE9377_GENE_AR	Rummagene Transcription Factor Associations 2026	1.0	null
lung	GeneRIF Biological Term Annotations	1.0	null
Muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.471
A549_Triamcinolone Acetonide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00838825
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73955
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GTEX-WFJO-1926-SM-3GILA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24854
Lung squamous cell carcinoma_LUSC_TCGA-22-4609-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
adipose tissue	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K38574421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68313
towards	GeneRIF Biological Term Annotations	1.0	null
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.758
PMC8709578-elife-69843-supp4.xlsx-HSF1_ChIP-seq_peaks-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Ki8751_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163601
GTEX-X4LF-1726-SM-3NMBZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05511
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16147
uterine cervix	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
EW-11	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Import of palmitoyl-CoA into the mitochondrial matrix	Reactome Pathways 2014	1.0	null
gigantocellular reticular nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.9905
Hypersensitivity	CTD Gene-Disease Associations	1.0	1.02262
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A0YN-11A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K08300592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84825
women	GeneRIF Biological Term Annotations	1.0	null
MHHCALL2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.92882
Attention Deficit Disorder with Hyperactivity	CTD Gene-Disease Associations	1.0	1.06261
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
periventricular stratum of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66844
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-d-Classification_of_camel_SON_basal_genes_-_enzymes_SON	Rummagene Transcription Factor Associations 2026	1.0	null
Entorhinal area, medial part, dorsal zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16303
BRD-K17140735_-666_PC3_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K77221872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30763
JcP contribution to LTL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.82696
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.82741
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Supplementary_Table_2A_Contrast_ATF4-def_control_vs_HCT116_control_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal adipose tissue amount	MPO Gene-Phenotype Associations	1.0	null
TAF2	Pathway Commons Protein-Protein Interactions	1.0	null
19036130-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
GSE189859,GSE189861_4_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T5JC-0008-SM-4DM6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42994
metabolism	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-670	TargetScan Predicted Conserved microRNA Targets	1.0	0.119151
molecular_function	GO Molecular Function Annotations 2015	1.0	null
BRD-K27737647_H 89 dihydrochloride_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.08118
Adenosine triphosphate	HMDB Metabolites of Enzymes	1.0	null
auditory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.060913
MCF7_Trametinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00987818
dorsal terminal nucleus of the accessory optic tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.09664
increased fatty acid oxidation	MGI Mouse Phenotype Associations 2023	1.0	null
GSE146982_3_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K27170250_7374280_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.607
fatty	GeneRIF Biological Term Annotations	1.0	null
valproic acid-4433	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HSPB1	Pathway Commons Protein-Protein Interactions	1.0	null
888	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27536
GSE201309_5_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
RASSF8	Pathway Commons Protein-Protein Interactions	1.0	null
GSE139987_1_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
imatinib_homo sapiens_gpl96_gds3044	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K98548675_Parthenolide_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE96641_1_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K95648552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13907
A549_Pracinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128836
Hyperglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.089
Pulmonary Fibrosis	CTD Gene-Disease Associations	1.0	1.35849
CLESACOSTAT	DGIdb Drug Targets 2026	1.0	4.411
heart disease	GWASdb SNP-Disease Associations	1.0	0.748359
MAP3K1	Pathway Commons Protein-Protein Interactions	1.0	null
increasing	GeneRIF Biological Term Annotations	1.0	null
UHMK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00533288
BRD-A18328003_GDC-0980_MCF10A_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
behavior/neurological phenotype	MPO Gene-Phenotype Associations	1.0	null
TOV-21G	COSMIC Cell Line Gene Mutation Profiles	1.0	null
AKT1_Activation - 6 week induction_GDS2308_718_mouse_Heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
fluticasone-2928	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE206729_2_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233647_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K00234327_RU 24969_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Danusertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015592
GSE234289_4_v_0_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K73809982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20957
plant vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.742152
ATP-grasp fold, subdomain 1	InterPro Predicted Protein Domain Annotations	1.0	null
protein-lipid complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.113487
Perturb_17410_KO_Kat7_SRP346205	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
TCF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8232
KYSE-410	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KIF20B	Pathway Commons Protein-Protein Interactions	1.0	null
CISD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09625
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
CD2AP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05005
EFO27	CCLE Cell Line Gene Mutation Profiles	1.0	null
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.422
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72574
MDST8	CCLE Cell Line Gene Mutation Profiles	1.0	null
NEUROD2-26341353-CORTEX-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
periventricular part of StrSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32239
Cervical Intraepithelial Neoplasia	HuGE Navigator Gene-Phenotype Associations	1.0	null
FRMD6	Pathway Commons Protein-Protein Interactions	1.0	null
disease	Phosphosite Textmining Biological Term Annotations	1.0	null
Anterior cingulate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.079
PMC3761196__F8	PFOCR Pathway Figure Associations 2024	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5117-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K98731749_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K16802067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07491
GTEX-PSDG-1626-SM-48TCQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55278
A549_XAV-939_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177758
BBX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03123
negative regulation of fatty acid metabolic process	GO Biological Process Annotations 2015	1.0	null
Fatty Liver	CTD Gene-Disease Associations	1.0	2.49587
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A9DE-11A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K91843292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35472
BRD-K68970089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05397
hsa-miR-4645-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
ZFP36	Pathway Commons Protein-Protein Interactions	1.0	null
DUXB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48569
Renal Insufficiency	CTD Gene-Disease Associations	1.0	1.58771
Lung adenocarcinoma_LUAD_TCGA-49-6744-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A431-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAL1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
19658189-TableS5	GeneSigDB Published Gene Signatures	1.0	null
endothelium-vascular	Phosphosite Textmining Biological Term Annotations	1.0	null
SNB19	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.847848
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Diabetes Mellitus, Type 2	CTD Gene-Disease Associations	1.0	1.31416
LOX-IMVI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01061
plumule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.25259
PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-1912_ChIP-Seq_H3K9me1_2_demethylation_and_ChIP-Seq_AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NFK9-0626-SM-2HMIV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27537
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EI-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Fat-fibroblast	Tabula Sapiens Gene-Cell Associations	1.0	14.8514
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
ZKSCAN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.687
GSE200430_1_v_0_sema3d_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ventral medial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19818
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052301
nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
protein tetramerization	GO Biological Process Annotations 2025	1.0	null
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	2.27589
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9972
GSE125007,GSE125008_3_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dapsone-1827	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
endurance	GeneRIF Biological Term Annotations	1.0	null
GSE217071_3_v_0_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF1	ChEA Transcription Factor Targets	1.0	null
GSE164874_5_v_1_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RRP1B	Pathway Commons Protein-Protein Interactions	1.0	null
Heart Failure	CTD Gene-Disease Associations	1.0	1.60734
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.521
ADP	HMDB Metabolites of Enzymes	1.0	null
GSE136591_0_v_1_akap11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
point	GeneRIF Biological Term Annotations	1.0	null
LS123	DepMap CRISPR Gene Dependency	1.0	2.40166
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.948595
GTEX-XMK1-0926-SM-4B66X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944098
PLEKHG1	Pathway Commons Protein-Protein Interactions	1.0	null
SKMEL5	BioGPS Cell Line Gene Expression Profiles	1.0	1.27251
19218430-TableS3	GeneSigDB Published Gene Signatures	1.0	null
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.826965
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.595
MDAMB436	CCLE Cell Line Gene CNV Profiles	-1.0	-1.331
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
increased oxygen consumption	MPO Gene-Phenotype Associations	1.0	null
GSE147662_2_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MITF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7481
HPAC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14847
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.948305
MFE319	DepMap CRISPR Gene Dependency	1.0	2.49166
SMC4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
rilmenidine-6512	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-TML8-2026-SM-32QOP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10833
TUBA1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-5.33896
KM12	CCLE Cell Line Gene Mutation Profiles	1.0	null
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06599
Medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02734
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.961079
GTEX-XV7Q-2626-SM-4BRVA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942438
SPARC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27784
GSE130081,GSE130082_5_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of primary metabolic process	GO Biological Process Annotations 2015	1.0	null
pka	Phosphosite Textmining Biological Term Annotations	1.0	null
ZBTB40	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890103
adult stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064645
BRD-A52650764_Ingenol 3, 20-dibenzoate_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Fasudil_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.013839
ethotoin-3809	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051274
Perturb_17819_KO_Bmal1_SRP260650	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.27412
abnormal energy expenditure	MPO Gene-Phenotype Associations	1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_4day-MOI-10^4_None_GSE43301	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.7018
Nausea	CTD Gene-Disease Associations	1.0	1.43919
GTEX-REY6-2426-SM-48FF5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87068
amino-acid betaine transport	GO Biological Process Annotations 2015	1.0	null
BRD-A43155244_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Belinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119363
IGF2BP3	Pathway Commons Protein-Protein Interactions	1.0	null
hormone	Phosphosite Textmining Biological Term Annotations	1.0	null
BRD-K53639581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07666
GSE158834_1_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
19225562-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Perturb_3820_KO_Satb2_SRP307573	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
abnormal energy homeostasis	MPO Gene-Phenotype Associations	1.0	null
acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.03788
PMC6119347__F2	PFOCR Pathway Figure Associations 2024	1.0	null
BXPC3_PANCREAS	CCLE Cell Line Proteomics	1.0	2.36921
A549_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201225
response to organic substance	GO Biological Process Annotations 2015	1.0	null
BRD-K45471346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0234
MDAMB175VII	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.7934
BRD-K88868628_-666_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8010-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XPVG-2526-SM-4B66D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36635
ventral subnucleus of MG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24317
GTEX-SSA3-0008-SM-47JWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29909
NCI-H1666	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.851223
Hypertrophy	CTD Gene-Disease Associations	1.0	2.11623
BRD-A45333398_PERIPLOCYMARIN_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_2571_KD_FKBP52_DRP008309	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_11858_KO_Erg|Fli1_SRP402910	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.3891
GSE149880_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K68174511_torin-2_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
C/EBP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.558
fyn	Phosphosite Textmining Biological Term Annotations	1.0	null
rs5186	GeneRIF Biological Term Annotations	1.0	null
hypercholesterolemia; hyperlipidemias	GAD Gene-Disease Associations	1.0	null
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9838
glucose	GAD Gene-Disease Associations	1.0	null
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055281
Perturb_10806_KO_Xbp1_SRP262377	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.11098
SREBP1-19666523-LIVER-FROM-C57BL-MICE-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
hydrocortisone-3284	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bulimia	HuGE Navigator Gene-Phenotype Associations	1.0	null
TAT protein transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.526
NCI-H596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41318
proguanil-3505	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K79568363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22944
BRD-K43634429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10623
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.97667
GSE195568_3_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CALCOCO2	Pathway Commons Protein-Protein Interactions	1.0	null
FAF2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K24748087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00517
ESO26	COSMIC Cell Line Gene Mutation Profiles	1.0	null
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
PMC8844187-Table_2.xlsx-prostate-DLX1_DLX1	Rummagene Transcription Factor Associations 2026	1.0	null
RT11284	CCLE Cell Line Gene Mutation Profiles	1.0	null
YAP1	ChEA Transcription Factor Targets	1.0	null
diabetic	Phosphosite Textmining Biological Term Annotations	1.0	null
HCC1419	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BUB1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A72180425_K784-3188_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IMP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14769
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.499
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
NCI-H128	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ASPC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Longissimus thoracis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.606
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13076
MAP7D1	Pathway Commons Protein-Protein Interactions	1.0	null
Electron transfer flavoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.79
BRD-K82217056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00798
Lung adenocarcinoma_LUAD_TCGA-44-6148-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF740	Pathway Commons Protein-Protein Interactions	1.0	null
JVM2	CCLE Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SCC4	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50216
Hypercholesterolemia	DisGeNET Gene-Disease Associations	1.0	null
indoles	Phosphosite Textmining Biological Term Annotations	1.0	null
BRD-K87779720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19173
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.83343
GTEX-X88G-0008-SM-47JWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14275
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4416014-pone.0125585.s010.xls-d_-BNC_network-Interactor_A_BNC1	Rummagene Transcription Factor Associations 2026	1.0	null
etioplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.417294
regulate	GeneRIF Biological Term Annotations	1.0	null
myoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.362646
BRD-K40264914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00053
GTEX-T5JW-1726-SM-3GADN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17697
LB1047RCC	DepMap CRISPR Gene Dependency	1.0	3.94218
Immune System Diseases	CTD Gene-Disease Associations	1.0	1.36848
BRD-K83988098_S1142_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K81651477_Parthenolide_NCIH2073_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OXRL-0008-SM-3NB29	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27218
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.664
GSE48812_2_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-VUSG-2626-SM-4KKZI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929221
CNOT11	Pathway Commons Protein-Protein Interactions	1.0	null
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4412
GSE129389_0_v_4_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
IQGAP1	Pathway Commons Protein-Protein Interactions	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NA-A4R0-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T2YK-0008-SM-4DM6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58435
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858305
EW-7	GDSC Cell Line Gene Expression Profiles	1.0	1.69225
BRD-K64317740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10794
pentolonium-2305	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lingula (I)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.91183
CPSF2	Pathway Commons Protein-Protein Interactions	1.0	null
single-organism intracellular transport	GO Biological Process Annotations 2015	1.0	null
Perturb_11240_KO_Bmal1_SRP260650	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.1559
BRD-K09854848_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-T8EM-1126-SM-3DB7D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29276
Adenoma, Liver Cell	CTD Gene-Disease Associations	1.0	1.62736
GSE140937,GSE140938_0_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
PGK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00624819
anion transport	GO Biological Process Annotations 2015	1.0	null
GSE226983_2_v_0_ddx5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Organic acidemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.3
GSE48812_2_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPS16	Pathway Commons Protein-Protein Interactions	1.0	null
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.82658
nuclear	GeneRIF Biological Term Annotations	1.0	null
organelle outer membrane	GO Cellular Component Annotations 2023	1.0	null
GSE116930,GSE116935_3_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-REY6-0326-SM-2TF5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2641
sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041826
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K77390737_X0379_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A617-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Arteriosclerotic cardiovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.544
MIA PACA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14847
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.336
carboxylase	GeneRIF Biological Term Annotations	1.0	null
PMC5303304-13073_2017_407_MOESM5_ESM.xlsx-mycn-sy5y-se_single_24DMSO_vs_4-Table_S4_Genes_differentially_expressed_by_48h_Dox_MYCN_overexpression_treatment_DE_comparison_with_SY5Y-MYCN_control_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NPJ8-0226-SM-48TBN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02323
outer SZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.954371
mood disorder	GWASdb SNP-Disease Associations	1.0	0.292166
ABC-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.51388
BRD-K72034655_PEUCEDANIN_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE252857_2_v_3_prednisone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
fatty acid homeostasis	GO Biological Process Annotations 2025	1.0	null
BRD-K89328601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09964
NFATC4	Pathway Commons Protein-Protein Interactions	1.0	null
Metabolic Diseases	CTD Gene-Disease Associations	1.0	1.3311
BRD-K78659596_MLN2238_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Viral cardiomyopathy_Myocardial tissue_GSE4172	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.81214
RPRD2	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7757125__F9	PFOCR Pathway Figure Associations 2023	1.0	null
ESS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-A67788537_Salermide_PC3_24.0_h_120.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEx Brain 20-29 vs 40-49	GTEx Tissue-Specific Aging Signatures	1.0	12.3819
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.67208
GSE184902_3_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE68156_0_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NPC1L1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K74148702_curcumin_MCF7_24.0_h_48.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
polymorphism	GeneRIF Biological Term Annotations	1.0	null
rats-sprague-dawley	Phosphosite Textmining Biological Term Annotations	1.0	null
endomembrane system	GO Cellular Component Annotations 2015	1.0	null
AR-27623747-22RV1-MOUSE-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K90027990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37462
tumors	GeneRIF Biological Term Annotations	1.0	null
succinate-CoA ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.876
Edinger-Westphal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.54053
TEAD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7287
BRD-K49507197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66151
BRD-K03662481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77106
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.26464
BRD-K72452130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14744
PMC7220941-41598_2020_64431_MOESM2_ESM.xlsx-WS2_2019_Affy_IDs_SignalsQN-Unnamed_2_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
Cardiomegaly	CTD Gene-Disease Associations	1.0	1.41559
BRD-A93236127_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.886995
THP1	CCLE Cell Line Gene Expression Profiles	1.0	1.42883
TRIM28	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A19500257_geldanamycin_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
susceptibility	GeneRIF Biological Term Annotations	1.0	null
Biotin transport and metabolism	Reactome Pathways 2024	1.0	null
GSE195559_2_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
FN1	Pathway Commons Protein-Protein Interactions	1.0	null
doxylamine-4235	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86029
CRCGN009_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.596
primary somatosensory cortex (area S1, areas 3,1,2)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15333
GSE124304_1_v_0_abl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPP30	Pathway Commons Protein-Protein Interactions	1.0	null
glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.05345
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.4961
Glioblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
COLO 205	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.38466
positive regulation of developmental process	GO Biological Process Annotations 2015	1.0	null
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
PMC6902611-40104_2019_400_MOESM2_ESM.ods-FA-SNA-Total_of_1_054_out_of_1_627_proteins_were_considered_for_analyses_65_SNAI1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K08307026_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WXYG-2526-SM-3NB3F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1311
BRD-K93918653_quizartinib_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Edema	HuGE Navigator Gene-Phenotype Associations	1.0	null
superficial stratum of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38362
H-89-6921	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
rostral division of OFCi (area 11)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.2704
GTEX-XV7Q-0008-SM-4BRWL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2258
BRD-K78867378_mw-A1-12_U937_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
L-741	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
sublayer 6a of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.76263
primary motor cortex (area M1, area 4)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0487
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.92475
Epididymal white adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.672
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.93137
SERBP1	Pathway Commons Protein-Protein Interactions	1.0	null
KRT9	Pathway Commons Protein-Protein Interactions	1.0	null
PMC4841025__F7	PFOCR Pathway Figure Associations 2023	1.0	null
insulin signaling pathway	KEGG Pathways	1.0	null
GSE189653,GSE203344_4_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RH28	DepMap CRISPR Gene Dependency	1.0	3.11648
PDLIM4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE88819_11_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.21999
HSPA9	Pathway Commons Protein-Protein Interactions	1.0	null
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
layer 2 of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01661
PMC12069319-Table1.xlsx-OCAB_p34_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
ACC3	BioGPS Cell Line Gene Expression Profiles	1.0	0.878767
GTEX-P4QT-0008-SM-48TDZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61242
regulation of cellular ketone metabolic process	GO Biological Process Annotations 2015	1.0	null
DAZAP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE152441,GSE152442_0_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5481-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K31390971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11781
CCDC160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07679
PMC3761196__F8	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-S4Z8-1726-SM-3K2AX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835023
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-E2A_DN3_ChIP-seq_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WFON-2326-SM-3LK7M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19987
PMC2927952__F3	PFOCR Pathway Figure Associations 2024	1.0	null
Familial hyperlipidemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.071
POR_KO_GDS1678_763_mouse_Liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.27489
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.818993
monovalent inorganic cation transport	GO Biological Process Annotations 2015	1.0	null
bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045864
H3K9me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
decamethonium bromide-2933	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K55113501_Digoxigenin_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154282
layer 1 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56277
BRD-K63945320_DIHYDROSAMIDIN_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE193402_0_v_3_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BDCA4+_DentriticCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.30961
mammary gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.243605
FTC-133	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K72636697_QL-X-138_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cell culture	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.397222
GSE195559_8_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF501	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01097
URM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3015
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.79886
PMC10861538-41467_2024_45669_MOESM7_ESM.xlsx-Sheet1-Supplementary_Data_4_DEGs_upon_KD_of_EVT_TFs_AR	Rummagene Transcription Factor Associations 2026	1.0	null
pattern	GeneRIF Biological Term Annotations	1.0	null
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00036
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Adult Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
regulation of fatty acid metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC11031761-mmc2.pdf-3-ZFPM2_ZFPM2	Rummagene Transcription Factor Associations 2026	1.0	null
Cingulate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.045
sulfur compound binding	GO Molecular Function Annotations 2015	1.0	null
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE173873_8_v_13_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_10833_KO_Xbp1_SRP262377	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.68348
concentration	GeneRIF Biological Term Annotations	1.0	null
GSE202434,GSE202438_2_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
transmembrane transport	GO Biological Process Annotations 2015	1.0	null
NCI-H1092	COSMIC Cell Line Gene Mutation Profiles	1.0	null
purine nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
GSE112762,GSE112767_2_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DPM1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE210682_2_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
amygdaloid complex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.916712
myeloid leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066657
Pancreas	GTEx Tissue Gene Expression Profiles 2023	1.0	3.80736
mitochondrial part	GO Cellular Component Annotations 2015	1.0	null
outer membrane	GO Cellular Component Annotations 2015	1.0	null
15721472-ER-positive-60genes	GeneSigDB Published Gene Signatures	1.0	null
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.87987
conversion	GeneRIF Biological Term Annotations	1.0	null
A549_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015767
GTEX-RM2N-1626-SM-2TF5N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.743
BRD-A56592690_PX12_PC3_6.0_h_30.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
inferior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.35816
paclitaxel_rattus norvegicus_gpl890_gse5337	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
t2dm	GeneRIF Biological Term Annotations	1.0	null
BRD-K67665252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07584
GMCL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18852
CRCGN011_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9502
GTEX-U4B1-1726-SM-3DB9F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8905
HUPT4	DepMap CRISPR Gene Dependency	1.0	4.01989
Soraphen A	DrugBank Drug Targets	1.0	null
NCI-H2135	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_Entinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148302
regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K64890080_BI-2536_HCC515_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PRRC2A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K19603900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91566
BRD-K76691746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38286
ribose phosphate biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GTEX-XQ3S-1326-SM-4BOPQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982971
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04258
long-chain fatty acid transport	GO Biological Process Annotations 2015	1.0	null
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Autoimmune Diseases	CTD Gene-Disease Associations	1.0	1.10665
BRD-K64514229_Toltrazuril_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K05975035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79239
GTEX-PWCY-1926-SM-3NB25	GTEx Tissue Sample Gene Expression Profiles	1.0	3.31365
BRD-K23703519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03831
UACC-257	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09493
orbital frontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.865064
abnormal cell physiology	MPO Gene-Phenotype Associations	1.0	null
Stat5a::Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.0702
SW900	COSMIC Cell Line Gene Mutation Profiles	1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.264696
hsa-miR-208b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
AUTS2-25519132-293T-REX-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MYC	ChEA Transcription Factor Targets	1.0	null
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46358
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF	Reactome Pathways 2014	1.0	null
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06472
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0487
SUGP2	Pathway Commons Protein-Protein Interactions	1.0	null
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052852
morbid obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.218374
GSE242290_1_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
protein-phosphatase-1	Phosphosite Textmining Biological Term Annotations	1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.533
hsa-miR-1293	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
inorganic ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
ribonucleoside metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-SN8G-0326-SM-32PLG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850433
BRD-A28970875_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ECH1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K16621460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10753
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QA-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE130217_5_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70335
r9 part of the lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0162
Erectile Dysfunction	CTD Gene-Disease Associations	1.0	1.21951
OCT4-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
WARS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00518533
BRD-K79561909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13019
RPS2	Pathway Commons Protein-Protein Interactions	1.0	null
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040896
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Neural Tube Defects	CTD Gene-Disease Associations	1.0	1.39198
GSE158834_1_v_5_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A19037878_trichostatin A_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07498
RARB-27405468-CHIP-SEQ-BRAIN-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K12866026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06045
GTEX-WFON-1826-SM-3GILG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2012
mania	GWASdb SNP-Phenotype Associations	1.0	0.486693
NFAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00593085
HDAC6_KO_GDS4375_532_mouse_Foxp3(+) Tregs	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
decreased respiratory quotient	MPO Gene-Phenotype Associations	1.0	null
morphology	Phosphosite Textmining Biological Term Annotations	1.0	null
Subcutis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.705
GTEX-WFG7-2426-SM-3GIL2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897334
GSE196962_2_v_6_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.977532
FU97	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XQ8I-0726-SM-4BOPU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884181
Parastrial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25101
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.78539
Methionine adenosyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.502
hsa-miR-548a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
cuneus, right, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15368
Myositis	CTD Gene-Disease Associations	1.0	1.40705
Metabolic dysfunction-associated steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.198
IGF2BP2	Pathway Commons Protein-Protein Interactions	1.0	null
PNU-0251126-4714	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cytosol	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BRD-A83124583_-666_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
nucleoside binding	GO Molecular Function Annotations 2015	1.0	null
8305C	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Fatty acid synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.648
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.21023
BRD-K66876909_linezolid_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bradycardia	CTD Gene-Disease Associations	1.0	1.14678
GSE229102_1_v_0_nr2f6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal circulating lipid level	MPO Gene-Phenotype Associations	1.0	null
layer IIIb of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06428
MRPL12	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9287735-mmc2.xlsx-NGR1-target-MI_network-node2_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
EFO-27	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC7757125__F9	PFOCR Pathway Figure Associations 2024	1.0	null
Succinate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.451
Culmen	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04797
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-R55G-2426-SM-2TC5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90387
KRT33B	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5767-11B-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.892
Perturb_7992_KO_Cyp26b1_ERP124899	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.50964
GSE224763_1_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
rostral presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.35937
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CD-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE175787_4_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE122067_3_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GATA2-22383799-G1ME-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
DENND6B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K66670355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4226
ethambutol-4120	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE158632_2_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PK45H	CCLE Cell Line Gene Mutation Profiles	1.0	null
BRD-K64577478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19103
GSE117045_1_v_2_amphetamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051277
low-density lipoprotein receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.029
NCI-H1299	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-A47598013_Citalopram hydrobromide_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
QGP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.45285
three	GeneRIF Biological Term Annotations	1.0	null
KPNB1	Pathway Commons Protein-Protein Interactions	1.0	null
positive regulation of lipid storage	GO Biological Process Annotations 2015	1.0	null
Extensor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.767
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GSE205070_2_v_9_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.73538
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FAM117B	Pathway Commons Protein-Protein Interactions	1.0	null
TBX3-20139965-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-3396-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE166920_6_v_4_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
chemdependency	GAD High Level Gene-Disease Associations	1.0	0.293278
GSE205316,GSE205317_2_v_1_nrip1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.840529
CP-690334-01-4380	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K07881437_S1107_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
high-density lipoprotein particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.933
GTEX-XUW1-2326-SM-4BOO5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08195
GSE196104,GSE196106_2_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE214212_2_v_1_chd6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K24132293_piperlongumine (HPLC)_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K18043221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02125
GSE211226_1_v_2_sirpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K50140147_CT-TAE684_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
quadriceps	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.842447
GTEX-Q2AI-1526-SM-3GIJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834892
Perturb_6216_KO_Mef2c_SRP227204	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
vitexin-2155	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormal circulating triglyceride level	MPO Gene-Phenotype Associations	1.0	null
GTEX-QDVN-0008-SM-48U2D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832968
BRD-K67011787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37175
BRD-K52340217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74877
GTEX-V955-2426-SM-3GAEF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14946
SERPINI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00647871
G84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.16332
BRD-K67860401_GSK-3b Inhibitor VIII_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EW-12	GDSC Cell Line Gene Expression Profiles	1.0	1.73619
all	GWASdb SNP-Phenotype Associations	1.0	0.036495
genotype	GeneRIF Biological Term Annotations	1.0	null
MAGEB10	Pathway Commons Protein-Protein Interactions	1.0	null
socalled	GeneRIF Biological Term Annotations	1.0	null
fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061956
BRD-K35780971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67223
mitochondrial outer membrane	GO Cellular Component Annotations 2025	1.0	null
Primary B cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.70328
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
Liver Neoplasms	CTD Gene-Disease Associations	1.0	2.33785
capan2	HPA Cell Line Gene Expression Profiles	-1.0	-1.07019
BRD-K85606544_HKI-272_NCIH596_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
pole plasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.165
alverine-2273	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cholestasis	CTD Gene-Disease Associations	1.0	1.97346
A549_Roxadustat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120725
HOXC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72189
JUP	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73446
resistance	Phosphosite Textmining Biological Term Annotations	1.0	null
single-organism transport	GO Biological Process Annotations 2015	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.961215
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
postmenopausal	GeneRIF Biological Term Annotations	1.0	null
SUM225CWN	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.11441
Mitochondrial envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.12
BRD-K80888628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01534
AIFM2	Pathway Commons Protein-Protein Interactions	1.0	null
kidney_c	HPA Tissue Sample Gene Expression Profiles	1.0	1.08233
TUBB	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K53619784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05308
Parahippocampal region	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.55
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041806
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D6-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RFX7	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPH2	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-6737-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K72461570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22039
Brain Ischemia	CTD Gene-Disease Associations	1.0	1.26732
BRD-K72533381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05155
PMC9232687-13238_2021_887_MOESM3_ESM.xlsx-37_KD_sgCDC20_vs_sgNTC-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HNF4A	ChEA Transcription Factor Targets	1.0	null
BRD-K26760349_HG-9-91-01_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Substance Withdrawal Syndrome	CTD Gene-Disease Associations	1.0	1.31178
UMUC3_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	7.45362
central gray substance of midbrain, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01402
ACHN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.913073
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.884913
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.51967
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_downregulated_genes-Unnamed_6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9046280-41467_2022_29963_MOESM5_ESM.xlsx-ASCL1_motif-Gene_Name_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K88742110_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K07303502_Arachidonyl trifluoro-methyl ketone_SKLU1_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Acute Chest Syndrome	DisGeNET Gene-Disease Associations	1.0	null
Peritoneal cavity	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.851
alpha-TC1.6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.059
SKA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47899
superficial stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04795
NELFA-20434984-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
A549_SB431542_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146766
GSE191015_1_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	1.0	null
Metabolism of lipids	Reactome Pathways 2024	1.0	null
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3086
BRD-K11928012_NCGC00182913-03_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
r5 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71203
PMC3255547-supp_007401_DMM007401TableS6.xls-EWS-FLI1_signatures-Unnamed_1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE93309_5_v_3_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE127790_9_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPS21	Pathway Commons Protein-Protein Interactions	1.0	null
AM-095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48863
Adipose tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.087
A-908292	DGIdb Drug Targets 2026	1.0	4.411
BRD-K67844266_MLN4924_THP1_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN014_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.24303
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
lateral subdivision of BNST	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.939377
LOX-IMVI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.920158
fao cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.443347
increased oxygen consumption	MGI Mouse Phenotype Associations 2023	1.0	null
PMC8763317-MO-018-D1MO00236H-s002.xlsx-PHF21A_S0_2-Gene_names_PHF21A	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AH-1726-SM-3NB2B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900496
abnormal enzyme/coenzyme level	MGI Mouse Phenotype Associations 2023	1.0	null
liver cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062203
BRD-K53046137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34387
muscle phenotype	MPO Gene-Phenotype Associations	1.0	null
bone marrow	HPA Tissue Protein Expression Profiles	-1.0	-1.68434
TBKBP1	Pathway Commons Protein-Protein Interactions	1.0	null
adrenal gland	HPA Tissue Protein Expression Profiles	1.0	1.16855
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8XJ-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
orlistat-6415	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Tremor	CTD Gene-Disease Associations	1.0	1.16467
Hep-G2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.719
key	GeneRIF Biological Term Annotations	1.0	null
FetalThyroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.04202
extend	GeneRIF Biological Term Annotations	1.0	null
biotin metabolic process	GO Biological Process Annotations 2015	1.0	null
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8386
GSE244072_4_v_6_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RRM1	Pathway Commons Protein-Protein Interactions	1.0	null
Regulation of cholesterol biosynthesis by SREBP (SREBF)	Reactome Pathways 2024	1.0	null
GSE241875_1_v_0_huwe1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-HL-60-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_HL-60_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
Anteroventral nucleus of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.12898
GTEX-P4PP-1726-SM-2S1NS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06178
BRD-K81082552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41892
azithromycin_pseudomonas aeruginosa_gpl84_gse12738	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17856
RBM10	Pathway Commons Protein-Protein Interactions	1.0	null
HEL	CCLE Cell Line Gene Expression Profiles	1.0	1.36724
GSE110580_1_v_0_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K96510191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5098
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.12028
ELFN1	Pathway Commons Protein-Protein Interactions	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0187
PMC9171494-Table_4.XLSX-drug-RARA_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.86471
BRD-K64517075_-666_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_BMS-911543_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015257
MRPL51	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34235
heterocycle biosynthetic process	GO Biological Process Annotations 2015	1.0	null
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.561
GSE210682_0_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WDR76	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56202
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17567
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A816-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9153
LSM12	Pathway Commons Protein-Protein Interactions	1.0	null
insulin resistance; metabolic syndrome x; obesity, abdominal	GAD Gene-Disease Associations	1.0	null
thioester biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Uterine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.124
18537972-TableS3	GeneSigDB Published Gene Signatures	1.0	null
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.49266
GSE66931,GSE73382_1_v_0_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
central nuclear group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.52028
NCOR2	Pathway Commons Protein-Protein Interactions	1.0	null
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3097
cellular amide metabolic process	GO Biological Process Annotations 2015	1.0	null
BTBD19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00555005
GSE216147_2_v_1_rbm20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_15357_KO_Tfap4_SRP212619	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.25908
acetyl-CoA carboxylase activity	GO Molecular Function Annotations 2023	1.0	null
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0173
BRD-K15600710_S1057_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PKBalpha_KO_GDS1784_196_mouse_Embryonic fibroblasts (MEFs) - 24h	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
chlorzoxazone-2100	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE140607_1_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
amygdaloid complex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.40607
BRD-K63547380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25489
triglyceride-rich plasma lipoprotein particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.132
purine nucleotide metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE252857_2_v_3_klf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K29441085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45046
precentral gyrus, left, bank of the precentral sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.842655
SNU738	CCLE Cell Line Gene CNV Profiles	-1.0	-2.07727
MAATS1	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-7710-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K61978712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17286
PMC9618568-41467_2022_34255_MOESM4_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE225656_2_v_3_tsc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Connective tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PHKA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35849
BRD-K17675814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67302
PMC4078240__F4	PFOCR Pathway Figure Associations 2024	1.0	null
A549_Ellagic acid_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174525
acyl-coa biosynthetic process	GO Biological Process Annotations 2015	1.0	null
CRCGN011_HEPG2_24H:E12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22648
Defective GIF causes intrinsic factor deficiency	Reactome Pathways 2014	1.0	null
MKN28	GDSC Cell Line Gene Expression Profiles	-1.0	-1.88531
BRD-K38227596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00706
GSE169713,GSE169715_1_v_2_tert_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC-27129775-CHIP-SEQ-CORNEA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE219195_1_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
raphe magnus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.71351
AMPK Signaling(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
GTEX-X8HC-0526-SM-4E3JA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923176
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8419
A549_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159494
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9667
OVCA-8 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.675
insulin	GeneRIF Biological Term Annotations	1.0	null
cytosol	GO Cellular Component Annotations 2015	1.0	null
THOC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11415
BICR 10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.855369
BRD-K23704908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12344
oral cavity cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.09429
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0838
overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.478289
MOV10	Pathway Commons Protein-Protein Interactions	1.0	null
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3992
GTEX-R55C-0008-SM-48FCF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.968755
MKI67	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
adipose	GeneRIF Biological Term Annotations	1.0	null
superficial stratum of r8Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01497
A549_MK-0752_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188375
GSE143944_2_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MGH-U4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.553
BRD-K53903639_480743.cdx_VCAP_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC2218	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.57563
PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
C-33-A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K90325960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10128
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.921221
MUC5AC	Pathway Commons Protein-Protein Interactions	1.0	null
reticulotegmental nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.1484
Metabolism of water-soluble vitamins and cofactors	Reactome Pathways 2024	1.0	null
GSE240645_1_v_0_u90926_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HIST1H1A	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6520398-41467_2019_10148_MOESM11_ESM.xls-FigS1a-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.76688
FARAGE	COSMIC Cell Line Gene Mutation Profiles	1.0	null
adult	Phosphosite Textmining Biological Term Annotations	1.0	null
Obesity	CTD Gene-Disease Associations	1.0	2.88009
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC	Reactome Pathways 2014	1.0	null
22RV1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
icSARS CoV_7Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.31194
Cardiovascular Diseases	CTD Gene-Disease Associations	1.0	2.03394
abnormal lipid homeostasis	MGI Mouse Phenotype Associations 2023	1.0	null
appendices_4a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.975079
BRD-K61414850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12997
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.252
BRD-K26015241_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE140936,GSE140938_2_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7617064-EMS151900-supplement-Extended_Data_Figure_7_Source_Data.xlsx-D23_NFIA-Logfold_change_threshold_1_0_1_NFIA	Rummagene Transcription Factor Associations 2026	1.0	null
muscle	GeneRIF Biological Term Annotations	1.0	null
PMC4839647__F3	PFOCR Pathway Figure Associations 2024	1.0	null
norcyclobenzaprine-2830	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COLO320	DepMap CRISPR Gene Dependency	1.0	2.12726
GSE200673,GSE200691_2_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE225735_0_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bundle sheath cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.632
pacc	GeneRIF Biological Term Annotations	1.0	null
GTEX-V1D1-0008-SM-4JBIJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34892
investigated	GeneRIF Biological Term Annotations	1.0	null
glycosyl compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
PMC4905481-oncotarget-07-11397-s002.xlsx-Pinin_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE229468,GSE229471_2_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cellular component organization or biogenesis	GO Biological Process Annotations 2015	1.0	null
Coronary Artery Disease	CTD Gene-Disease Associations	1.0	1.45273
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7434-11A-01R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bundle sheath cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.532274
abnormal hormone level	MPO Gene-Phenotype Associations	1.0	null
GSE137144_4_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lipodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.116
GSE224311_3_v_0_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nabumetone-6487	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XXEK-1426-SM-4BRW1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.957324
NCIH2052	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.33455
IST-MES1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Acetyl-CoA	MW Enzyme Metabolite Associations	1.0	null
HARA	CCLE Cell Line Gene CNV Profiles	1.0	1.35652
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.833
Prostate adenocarcinoma_PRAD_TCGA-VP-A879-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X3Y1-0926-SM-3P5YT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09804
ORC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5021
GSE172146_2_v_1_mettl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Adenoma	CTD Gene-Disease Associations	1.0	1.32162
GTEX-PLZ6-1526-SM-2S1OC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70734
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-1.11844
single-organism process	GO Biological Process Annotations 2015	1.0	null
BRD-K40175214_torin-1_SKBR3_3_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.97439
GSE145323,GSE145324_1_v_0_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33971
CMK115	DepMap CRISPR Gene Dependency	1.0	2.35564
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
patch-clamp-techniques	Phosphosite Textmining Biological Term Annotations	1.0	null
blood	GTEx Tissue Gene Expression Profiles	-1.0	-2.10021
precuneus, right, superior lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.01917
GTEX-XV7Q-2326-SM-4BRVZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24089
MUC3A	Pathway Commons Protein-Protein Interactions	1.0	null
AB80 (BRCA1)	NURSA Protein Complexes	1.0	null
hindlimb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.973716
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.944
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040396
PMC6985208__F2	PFOCR Pathway Figure Associations 2023	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-8454-11A-01R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDVJ-1826-SM-2S1P3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9996
GSE174701_1_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
mRNA_ESX1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GSE125782_3_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PDS5B	Pathway Commons Protein-Protein Interactions	1.0	null
inferolateral temporal cortex (area TEv, area 20)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.951242
LGALS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00388539
BRD-K43889095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67975
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5ED-11A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K49328571_dasatinib_HCC515_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172854
polymorphisms	GeneRIF Biological Term Annotations	1.0	null
KMBC2	DepMap CRISPR Gene Dependency	1.0	2.13737
BRD-K23203419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33478
GSE149943_1_v_0_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SUCS-0008-SM-4DM53	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54838
female	Phosphosite Textmining Biological Term Annotations	1.0	null
PMC5838194__F3	PFOCR Pathway Figure Associations 2023	1.0	null
GSE216757_4_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
RNASE6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46269
PMC9130782-Table_3.xlsx-downregulated-ZNF366_ZNF366	Rummagene Transcription Factor Associations 2026	1.0	null
Hepa-RG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.554
Parasubiculum, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48311
GTEX-P4QR-0008-SM-48TE2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24401
abnormal eating behavior	MPO Gene-Phenotype Associations	1.0	null
GTEX-WY7C-2426-SM-3NB2V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85608
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.829656
Fatty Liver, Alcoholic	DisGeNET Gene-Disease Associations	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.831078
GTF3C4	Pathway Commons Protein-Protein Interactions	1.0	null
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6656
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
cho-cells	Phosphosite Textmining Biological Term Annotations	1.0	null
Rectum adenocarcinoma_READ_TCGA-G5-6572-02A-12R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Multiple carboxylase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.692
BRD-K10696228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15518
HECTD1	Pathway Commons Protein-Protein Interactions	1.0	null
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.33
CRCGN014_HEPG2_24H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83808
BRD-K64748422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74233
GTEX-XMK1-2226-SM-4B673	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879448
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.21925
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K08219523_5-nonyloxytryptamine_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142129
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.29772
Confusion	CTD Gene-Disease Associations	1.0	1.24781
Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YO-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF7	ChEA Transcription Factor Targets	1.0	null
USP36	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970051
alar plate of m1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06039
amoxapine-6650	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.89286
Biotin carboxylase, C-terminal	InterPro Predicted Protein Domain Annotations	1.0	null
Diabetes Mellitus	DisGeNET Gene-Disease Associations	1.0	null
GTEX-OHPL-1826-SM-2YUN8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836224
CKM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.055
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.85584
MTDH_DEPLETION_GDS3179_98_human_LM2 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ZP-A9CZ-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bounding membrane of organelle	GO Cellular Component Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YM-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6972-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE131649_2_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.25956
BRD-A39646320_H7270_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_2632_KD_SRSF1_SRP297599	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
proteinuria	GeneRIF Biological Term Annotations	1.0	null
Mitochondrial fatty acid beta-oxidation multienzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.605
MXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.377
c2c12 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.410491
End stage renal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.374
GTEX-OHPN-0011-R3A-SM-2I5FC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868815
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10337103-13046_2023_2747_MOESM2_ESM.pdf-3-ENSG00000185507_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
beta	GeneRIF Biological Term Annotations	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.22113
calcium-calmodulin-dependent-protein-kinases	Phosphosite Textmining Biological Term Annotations	1.0	null
GSE171311_0_v_1_ellagic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.954932
TUBB4B	Pathway Commons Protein-Protein Interactions	1.0	null
Lsm2-8 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.589
CALM1	Pathway Commons Protein-Protein Interactions	1.0	null
explained	GeneRIF Biological Term Annotations	1.0	null
GTEX-U8T8-0008-SM-4DXSP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830169
TRPM1	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7740-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QCQG-2126-SM-2S1P8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00855
Fast muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.346
principal pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15858
Skin Diseases	CTD Gene-Disease Associations	1.0	1.21855
trovafloxacin_homo sapiens_gpl96_gse9166	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF_D1_vs_D10-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.551
microbody	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.65001
aMEF-2	MotifMap Predicted Transcription Factor Targets	1.0	null
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
POLG	Pathway Commons Protein-Protein Interactions	1.0	null
NUGC3	CCLE Cell Line Gene Mutation Profiles	1.0	null
RBFOX2	Pathway Commons Protein-Protein Interactions	1.0	null
organic cyclic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
FLNA	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K15389388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30724
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.846719
Perturb_17753_KO_Nae1_SRP407900	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Lung adenocarcinoma_LUAD_TCGA-55-6970-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11953390-41598_2025_94761_MOESM1_ESM.xlsx-Table_S3-Table_S3_The_result_of_MR_analysis_and_sensitivity_analysis_for_CKD_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K17705806_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_10822_KO_Xbp1_SRP197108	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.52561
DNAJB1	Pathway Commons Protein-Protein Interactions	1.0	null
EXOSC1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE199541_2_v_5_mbd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZCCHC8	Pathway Commons Protein-Protein Interactions	1.0	null
CHST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17634
purine ribonucleoside biosynthetic process	GO Biological Process Annotations 2015	1.0	null
TE4	CCLE Cell Line Gene Expression Profiles	-1.0	-2.42876
GSE221327_1_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HNRNPK	Pathway Commons Protein-Protein Interactions	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
Cochlear nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0261
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3465-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RT112	CCLE Cell Line Gene Mutation Profiles	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Ischemic Attack, Transient	CTD Gene-Disease Associations	1.0	1.02858
carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.336144
BRD-K55598155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22817
FZD10	Pathway Commons Protein-Protein Interactions	1.0	null
t60-adrenal_female_8w	MoTrPAC Rat Endurance Exercise Training	-1.0	-2.11616
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-E2A_DN4_ChIP-seq_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
HUPT3	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
C1QBP	Pathway Commons Protein-Protein Interactions	1.0	null
PMC5105166-ncomms13331-s11.xlsx-Sheet1-Supplementary_Data_10_Overlap_of_upregulated_genes_in_MEF2D-rearranged_cases_with_public_ChIPseq_RNAseq_data_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18786
GSE175787_5_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K10182289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45186
primary auditory cortex (core)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.847066
tetramisole-4412	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T2IS-0226-SM-32QPH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86427
monocarboxylic acid binding	GO Molecular Function Annotations 2015	1.0	null
GSE182680,GSE182683_7_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K73125678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55465
GTEX-T5JW-2026-SM-4DM63	GTEx Tissue Sample Gene Expression Profiles	1.0	0.996927
PMC6214187__F1	PFOCR Pathway Figure Associations 2023	1.0	null
proto-oncogene-proteins	Phosphosite Textmining Biological Term Annotations	1.0	null
GSE144231_4_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cofactor metabolic process	GO Biological Process Annotations 2015	1.0	null
ChREBP activates metabolic gene expression	Reactome Pathways 2014	1.0	null
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	2.40094
MCCC1	Pathway Commons Protein-Protein Interactions	1.0	null
A2058	Achilles Cell Line Gene Essentiality Profiles	1.0	1.5535
superficial stratum of PrS (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43182
PMC4390253__F1	PFOCR Pathway Figure Associations 2023	1.0	null
r5 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.95296
ESC_J1_UP_LATE.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
BRD-K71496240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59802
HCFC1	Pathway Commons Protein-Protein Interactions	1.0	null
leg	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.01725
digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.00458
PMC12754469-ab-25-0159-Supplementary-1.pdf-11-TEAD3_TEAD3	Rummagene Transcription Factor Associations 2026	1.0	null
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
A-427 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.609
gefitinib-541	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nucleoside phosphate binding	GO Molecular Function Annotations 2015	1.0	null
superficial stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21071
RPLP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.994297
fat_8b	HPA Tissue Sample Gene Expression Profiles	1.0	1.9941
HT29	CCLE Cell Line Gene Mutation Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A5F6-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE122067_3_v_0_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Acetyl-coenzyme A carboxyltransferase, C-terminal	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K89093471_VU0418934-2_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Activation of gene expression by SREBF (SREBP)	Reactome Pathways 2024	1.0	null
ventrolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.85153
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05535
Pancreatitis	CTD Gene-Disease Associations	1.0	1.39924
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DIRAS2	Pathway Commons Protein-Protein Interactions	1.0	null
fatty acid biosynthesis initiation	HumanCyc Pathways	1.0	null
FOXC2	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Tanespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145573
A549_Divalproex Sodium_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163983
TEAD4	ChEA Transcription Factor Targets	1.0	null
GSE152734,GSE152735_2_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cerebellar Diseases	CTD Gene-Disease Associations	1.0	1.18424
hepatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.308251
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Heart Defects, Congenital	CTD Gene-Disease Associations	1.0	1.15089
extensor	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.19845
BRD-K27870441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32071
SMC3	Pathway Commons Protein-Protein Interactions	1.0	null
TXN	Pathway Commons Protein-Protein Interactions	1.0	null
TRIM41	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A71390734_4-Demethoxydaunorubicin hydrochloride (65)_RMUGS_6.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Primary somatosensory area, nose, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.14643
BRD-K99847716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04094
vitamin binding	GO Molecular Function Annotations 2015	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-RXRG_RXRG	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Fedratinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123517
RALY	Pathway Commons Protein-Protein Interactions	1.0	null
TDG	Pathway Commons Protein-Protein Interactions	1.0	null
CAPZB	Pathway Commons Protein-Protein Interactions	1.0	null
KIAA2026	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.976352
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.44847
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A8RY-11A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
horizontal nucleus of the diagonal band, transitional part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06418
GSE131649_4_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
citrate	GeneRIF Biological Term Annotations	1.0	null
increased body weight	GWASdb SNP-Phenotype Associations	1.0	0.647367
cytoplasmic part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Vision Disorders	CTD Gene-Disease Associations	1.0	1.05685
blood	Phosphosite Textmining Biological Term Annotations	1.0	null
Sarcoma_SARC_TCGA-Z4-A9VC-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
interspecies	GeneRIF Biological Term Annotations	1.0	null
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CCK-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE92364_1_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LI7	CCLE Cell Line Gene Mutation Profiles	1.0	null
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K68665079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11531
LOVO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
organophosphate biosynthetic process	GO Biological Process Annotations 2015	1.0	null
High grade glioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
non-alcoholic fatty liver	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.5
TCP1	Pathway Commons Protein-Protein Interactions	1.0	null
mitochondrial transmembrane transport	GO Biological Process Annotations 2015	1.0	null
PMC9618568-41467_2022_34255_MOESM5_ESM.xlsx-TAL2-Unnamed_0_TAL2	Rummagene Transcription Factor Associations 2026	1.0	null
coa	GeneRIF Biological Term Annotations	1.0	null
U-118-MG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-A48237631_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
17894856-SuppList2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-OHPN-0008-SM-4E3HW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932662
BRD-A52886023_A8674_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC4619386__F6	PFOCR Pathway Figure Associations 2023	1.0	null
PMC6861325__F4	PFOCR Pathway Figure Associations 2023	1.0	null
GSE126463_0_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
spiradoline-3818	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K55191674_PENICILLIN G POTASSIUM_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Stevens-Johnson Syndrome	CTD Gene-Disease Associations	1.0	1.01852
Perturb_6118_KO_Fak_SRP279401	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.07142
FAM193A	Pathway Commons Protein-Protein Interactions	1.0	null
HOP92	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.38448
methylcrotonoyl-CoA carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.747
isoquinolines	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEx Brain 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	7.36495
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21644
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09323
BRD-K92812209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3736
GSE70499_5_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248883_0_v_1_shmt2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Integral component of peroxisomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.799
single-organism biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Drug Toxicity	HuGE Navigator Gene-Phenotype Associations	1.0	null
ABCA1	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6982-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.7884
BRD-K02708799_GSK-1059615_BT20_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PHH	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.759
FAO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.926
Rectum adenocarcinoma_READ_TCGA-AF-2692-11A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K21671578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90949
PRPF40A	Pathway Commons Protein-Protein Interactions	1.0	null
A549_MLN8054_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123092
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_15772_KO_Uxt_SRP240277	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Lung adenocarcinoma_LUAD_TCGA-50-5932-11A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
XYLT1	Pathway Commons Protein-Protein Interactions	1.0	null
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25965
GSE221020,GSE221023_2_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
outer SZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00592
Learning Disorders	CTD Gene-Disease Associations	1.0	1.99934
CRCGN016_MCF10A.TP53.M_24H:B23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4866
Inflammatory bowel disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
shikonin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91242
sulfur compound metabolic process	GO Biological Process Annotations 2015	1.0	null
HCC2814	Achilles Cell Line Gene Essentiality Profiles	-1.0	-2.11365
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
LYL1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Drug Eruptions	CTD Gene-Disease Associations	1.0	1.39785
GSE172016_2_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K04010869_PROSTAGLANDIN A1_A673_6.0_h_1.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
duodenum	HPA Tissue Protein Expression Profiles	1.0	1.16855
Perturb_10944_KO_Mtdh_SRP080807	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.63242
ATP1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23223
BRD-K35668999	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33672
LN18	CCLE Cell Line Gene Mutation Profiles	1.0	null
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58322
BRD-K14221570_Benzopurpurin (B)_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
acetyl-CoA metabolic process	GO Biological Process Annotations 2025	1.0	null
Perturb_6578_KO_Zeb2_SRP066910	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
BRD-K98490050_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE114992,GSE114993_7_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K61733751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22114
GSE166920_6_v_8_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Vascular Diseases	CTD Gene-Disease Associations	1.0	1.49045
CEBPB-21427703-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
6-phosphofructokinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.332
DDX3X	Pathway Commons Protein-Protein Interactions	1.0	null
GSE213588_9_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PFEIFFER	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.956985
GSE242199_6_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K70322385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30518
GSE213650_3_v_2_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201270,GSE201272_0_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Ruxolitinib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117699
BRD-K83892314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16533
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.43058
Uterine disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
CRCGN011_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.14615
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.843318
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7771094-12920_2020_832_MOESM5_ESM.txt--ATF2_ATF2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE245418_0_v_2_cd109_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_3_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01054
BRD-K24538875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06317
MZ in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.973415
SNRPD2	Pathway Commons Protein-Protein Interactions	1.0	null
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1863
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31321
GTEX-RTLS-0226-SM-2TF5E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12494
flufenamic acid-2267	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE203308_8_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K63500288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35789
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.31049
liver	Phosphosite Textmining Biological Term Annotations	1.0	null
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22069
BRD-K76907295_VU0418947-2_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
accessory entopeduncular nucleus (post-migratory)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31483
TRAP1	Pathway Commons Protein-Protein Interactions	1.0	null
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.27249
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZR-06A-21R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
thioester metabolic process	GO Biological Process Annotations 2015	1.0	null
KM12	CCLE Cell Line Gene CNV Profiles	1.0	1.54884
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4619-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K10494344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54625
Atrophy	CTD Gene-Disease Associations	1.0	1.82708
PMC6828764-41419_2019_2062_MOESM2_ESM.xlsx-GATA3_UTX_promoter_gene-Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
HSPA8	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R55D-0626-SM-3GAD5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08692
H9c2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.224
ITGAL	Pathway Commons Protein-Protein Interactions	1.0	null
FANCM	Pathway Commons Protein-Protein Interactions	1.0	null
ZBTB18	Pathway Commons Protein-Protein Interactions	1.0	null
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF-_SURVIVAL-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MDA-MB-361	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DG-75	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KM12	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-P78B-0226-SM-3NB1Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14682
LCN12	Pathway Commons Protein-Protein Interactions	1.0	null
GSE164874_5_v_7_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_1670_KO_Rigi_SRP119759	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.93974
trunk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.249329
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.8417
BRD-K35960502_NICLOSAMIDE_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160083,GSE160084_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K62147342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13422
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
IGR37	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42103
HNT-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.91145
LAN2	DepMap CRISPR Gene Dependency	1.0	7.6441
BRD-K76833108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45903
fatty acid synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.50107
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882439
GSE185744,GSE185747_2_v_3_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH1734	CCLE Cell Line Gene Mutation Profiles	1.0	null
DYRK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02676
SMTN	Pathway Commons Protein-Protein Interactions	1.0	null
MZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00399
A549_Azacitidine_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131791
Malignant mesothelioma of pleura_Pleura_GSE2549	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.87799
GSE220600_1_v_2_clpp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S4P3-1526-SM-3K2AV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56149
ZNF85	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6754
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.21232
RPL12	Pathway Commons Protein-Protein Interactions	1.0	null
captopril_mus musculus_gpl1261_gds3683	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC12822963-pone.0339296.s005.xlsx-Sheet1-HIF1A_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
NAMALWA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE169155_1_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ampk	GeneRIF Biological Term Annotations	1.0	null
transport	GO Biological Process Annotations 2015	1.0	null
18310505-TableS1	GeneSigDB Published Gene Signatures	1.0	null
MIA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00547785
DV90	CCLE Cell Line Gene Mutation Profiles	1.0	null
GSE213588_8_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204298
carbohydrate metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.05345
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.836917
PRKAA1	PhosphoSitePlus Substrates of Kinases	1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.76464
BRD-K69097969_VU0418939-2_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MCF2L2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Tucidinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131114
A4 noradrenergic cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43349
AMP activated protein kinase signaling	WikiPathways Pathways 2024	1.0	null
BRD-K68174511_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T8EM-1326-SM-3DB7G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15237
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20R-11A-11R-A16R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cofactor biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A3I1-11A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
sensory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.174617
ion transport	GO Biological Process Annotations 2015	1.0	null
ligase activity	GO Molecular Function Annotations 2015	1.0	null
superficial stratum of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23993
BRD-K61717269_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC12627768-41598_2025_24410_MOESM1_ESM.pdf-6-DDIT3_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
primary motor-sensory cortex (samples)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.867047
Hypoxia_Astrocyte_GSE4483	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.821423
basomedial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.4313
adenosine-triphosphate	Phosphosite Textmining Biological Term Annotations	1.0	null
PMC6591464-Table_4.xlsx-Sheet_1-Non-AIRE_regulated_genes_random_set_1_AIRE	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A51777634_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE149075_3_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ovary	HPA Tissue Protein Expression Profiles	-1.0	-1.68434
NCIH1993	DepMap CRISPR Gene Dependency	1.0	2.7415
S100A9	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K63024248	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75505
strong	GeneRIF Biological Term Annotations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7211-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-V955-2026-SM-3GAFA	GTEx Tissue Sample Gene Expression Profiles	1.0	2.07239
cricetinae	Phosphosite Textmining Biological Term Annotations	1.0	null
Tricarboxylic acid cycle enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.552
GSE224556,GSE224557_8_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.27745
BRD-K35945596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74784
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.042878
AP4B1	Pathway Commons Protein-Protein Interactions	1.0	null
15297395-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
VZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.069
KYSE150	CCLE Cell Line Gene Mutation Profiles	1.0	null
GSE180200,GSE180201_15_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152937_12_v_1_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12069319-Table1.xlsx-OCAB_WT_BirA-Gene_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K46056750_HY-10992_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
carbohydrate derivative biosynthetic process	GO Biological Process Annotations 2015	1.0	null
RPS27L	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-8258-11A-01R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPA-26348894-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-TKQ1-0226-SM-33HB5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09343
GSE207282_1_v_0_polydatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
HSPE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25621
Depressive Disorder	CTD Gene-Disease Associations	1.0	1.94563
GSE184902_3_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Isocitrate dehydrogenase complex (NAD+)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.998
GSE158502,GSE158506_3_v_0_fat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE198165,GSE198166_5_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PPP2CB	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Tazemetostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134485
Lung Injury	CTD Gene-Disease Associations	1.0	1.5254
superficial stratum of TG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27895
transcription	GeneRIF Biological Term Annotations	1.0	null
BRD-K61139423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12096
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.248
GSE201270,GSE201272_5_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01425
decreased liver glycogen level	MGI Mouse Phenotype Associations 2023	1.0	null
PMC7181746-41467_2020_15886_MOESM8_ESM.xlsx-Patient_8_CCF-Affected_Genes_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
White adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.415
iopanoic acid-2965	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XYKS-1826-SM-4E3JV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13416
rodent	GeneRIF Biological Term Annotations	1.0	null
GTEX-XQ8I-0626-SM-4BOPT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10451
GTEX-XBED-1326-SM-4AT4F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.187
BRD-K68548958_-666_HCT116_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K42918627_GSK-2126458_HME1_3_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
glia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081197
Rudiment single hybrid motif	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K74710236_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DDX51	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_11311_KO_Bmal1_SRP060295	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-17.8633
Perturb_10842_KO_Xbp1_SRP262377	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.59396
t70-white-adipose_female_8w	MoTrPAC Rat Endurance Exercise Training	1.0	3.79662
BRD-A16119053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06184
periventricular stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.30277
CNTN5	Pathway Commons Protein-Protein Interactions	1.0	null
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.3969
BRD-K77987635_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Suprageniculate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.96977
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.970814
BRD-K26273412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51258
differential	GeneRIF Biological Term Annotations	1.0	null
LYL1	ChEA Transcription Factor Targets	1.0	null
SK-MEL-24	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE152441,GSE152442_7_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RVPU-0008-SM-3NM8B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1108
Mitochondrion	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.606
BRD-K04968881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85853
posterodorsal tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70401
Perturb_11242_KO_Sirt6_SRP190930	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.66684
nucleotide metabolic process	GO Biological Process Annotations 2015	1.0	null
abnormal white adipose tissue morphology	MPO Gene-Phenotype Associations	1.0	null
t70-white-adipose_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	4.3286
GSE205550,GSE205552_2_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
other source	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.396465
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
mediodorsal nucleus of thalamus_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.94786
BRD-K53414658_tivozanib_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
A549_PFI-1_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170518
NCIH2291	CCLE Cell Line Gene Mutation Profiles	1.0	null
abnormality of body weight	GWASdb SNP-Phenotype Associations	1.0	0.337931
PLOD2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K65737790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20615
GTEX-WRHK-1626-SM-3MJFH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61664
ARFGAP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K91297952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05042
BRD-K62541003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92442
GSE138633_2_v_0_bag3_human	RummaGEO Gene Perturbation Signatures	1.0	null
TULP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1806
Inferior colliculus, central nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45349
GSE193999,GSE194000_3_v_2_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Alzheimer Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
glycogen	Phosphosite Textmining Biological Term Annotations	1.0	null
PMC5771393-ACEL-17-na-s003.xlsx-FOXO1_Correlation_Pos-HUGO_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_and_sensitivity_analysis_for_IPF_susceptibility_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.075174
information	GeneRIF Biological Term Annotations	1.0	null
NCIH1385	CCLE Cell Line Gene CNV Profiles	1.0	1.56312
BRD-K49328571_dasatinib_MCF10A_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22392
GSE216757_0_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Fatty acid biosynthesis	WikiPathways Pathways 2024	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7284-01B-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DDX6	Pathway Commons Protein-Protein Interactions	1.0	null
Hypercholesterolemia	CTD Gene-Disease Associations	1.0	1.86806
Platelet alpha granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.758
GSE154577_7_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.97244
decreased liver triglyceride level	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K34604755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15548
BRD-A47166394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37104
Perturb_2417_KD_PPP3CA_DRP007751	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K08995282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52464
BRD-K43797669_genistein_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE81193_3_v_5_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_TMP195_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129166
GSE129153_0_v_1_forskolin_human	RummaGEO Drug Perturbation Signatures	1.0	null
plastid stroma	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.606128
BRD-K36258877_AZ 10417808_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
prednisone-1897	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TP63	ChEA Transcription Factor Targets	1.0	null
BRD-K43918778	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80299
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.139
organic anion transport	GO Biological Process Annotations 2015	1.0	null
LIVF001-007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4367
GSE208096_1_v_0_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
positive regulation of organ growth	GO Biological Process Annotations 2015	1.0	null
LS1034	DepMap CRISPR Gene Dependency	1.0	2.52592
Salivary_Gland-fibroblast	Tabula Sapiens Gene-Cell Associations	1.0	3.54029
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.338
SKM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59678
PRKAG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00684635
BRD-K78007953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72842
cuneus, left, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.892894
MCF7_Luminespib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00935176
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.902787
BRD-K64953645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97785
nitric-oxide	Phosphosite Textmining Biological Term Annotations	1.0	null
HLCS	Pathway Commons Protein-Protein Interactions	1.0	null
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
Myotube	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.798
GTEX-WXYG-0926-SM-3NB2O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03169
positive regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
ATP-grasp fold, subdomain 2	InterPro Predicted Protein Domain Annotations	1.0	null
GSE244072_10_v_8_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Dasatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0271479
Hypercholesterolemia	HuGE Navigator Gene-Phenotype Associations	1.0	null
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.322
KMS21BM	CCLE Cell Line Gene Expression Profiles	1.0	2.35252
SURF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24453
HCC2998	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.41811
Lung squamous cell carcinoma_LUSC_TCGA-51-4079-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-NJ-A55R-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CREB1	ChEA Transcription Factor Targets	1.0	null
Gustatory areas, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21703
sufficient	GeneRIF Biological Term Annotations	1.0	null
Perihypoglossal nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72265
BRD-K70358946_Aripiprazole_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17709
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.64638
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	2.0483
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56052
common	GeneRIF Biological Term Annotations	1.0	null
BRD-K16406336_METHYLENE BLUE_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7897-01A-21R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE178340_7_v_4_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE156708_1_v_0_fbxo11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
side	GeneRIF Biological Term Annotations	1.0	null
GSE206729_4_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
hypoglycemia	MPO Gene-Phenotype Associations	1.0	null
Human - Heart - L2 - Adipocyte	HuBMAP Azimuth Cell Type Annotations	1.0	null
GSE258991_5_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Agranular insular area, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44806
troglitazone-4456	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Plastid acetyl-CoA carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.602
IZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.855307
Retinal vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.211
Nucleus prepositus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78248
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3844
GSE126776_2_v_1_pelp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ca2+	Phosphosite Textmining Biological Term Annotations	1.0	null
Defective TCN2 causes hereditary megaloblastic anemia	Reactome Pathways 2014	1.0	null
BRD-A71765365_Reserpine_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75173
ischemic	Phosphosite Textmining Biological Term Annotations	1.0	null
hsa-miR-4708-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE242333_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239844_7_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Posterodorsal preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08079
BRD-K33308633_INCA-6_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24477
GSE240027,GSE240030_5_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148692,GSE148695_5_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
rifampicin-4126	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Myocardial infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.303
GSE178714_5_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAGED1	Pathway Commons Protein-Protein Interactions	1.0	null
ES-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.932159
Porphyria Cutanea Tarda	CTD Gene-Disease Associations	1.0	1.13347
blast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071646
LAMTOR5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45053
MET_knockout_250_GDS3148	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.68383
GTEX-RU1J-1726-SM-2TF5S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36382
MM.1S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.27144
KP3	DepMap CRISPR Gene Dependency	1.0	2.15611
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-6033-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
BCOR-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
abnormal respiratory quotient	MPO Gene-Phenotype Associations	1.0	null
BRD-K64606589_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BronchialEpithelialCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.861868
ZNF541	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.971389
skeletal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.73579
Nucleomorph	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.502
PSD4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K78856515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03866
negative regulation of fatty acid oxidation	GO Biological Process Annotations 2015	1.0	null
GTEX-XBED-2626-SM-4E3J5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831355
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9706
CCT6A	Pathway Commons Protein-Protein Interactions	1.0	null
8305C_THYROID	CCLE Cell Line Proteomics	1.0	4.30419
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
purine ribonucleoside triphosphate binding	GO Molecular Function Annotations 2015	1.0	null
rolitetracycline-3369	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
layer V of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.35488
Hepatomegaly	CTD Gene-Disease Associations	1.0	2.37617
superficial stratum of CoPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.65607
Defective CUBN causes hereditary megaloblastic anemia 1	Reactome Pathways 2014	1.0	null
GSE199543,GSE239447_0_v_4_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
IGROV1	CCLE Cell Line Gene Mutation Profiles	1.0	null
H3K9me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K81418486_vorinostat_SKMEL1_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SkeletalMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.23709
GTEX-U3ZN-2626-SM-3DB7T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03366
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.267
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.73402
abnormal hypodermis fat layer morphology	MPO Gene-Phenotype Associations	1.0	null
heterocyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K67525206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39474
monocarboxylic acid transport	GO Biological Process Annotations 2015	1.0	null
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.544
CP in retrosplenial cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00208
hsa-miR-4793-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.58534
BRD-K41260949_valproic acid_SW948_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
microinflammation	GeneRIF Biological Term Annotations	1.0	null
Micronuclei, Chromosome-Defective	CTD Gene-Disease Associations	1.0	1.42913
oxoacid metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE168797_2_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K46152990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20522
lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.158266
GSE180185_7_v_8_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal circulating hormone level	MPO Gene-Phenotype Associations	1.0	null
RXR-22158963-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
D-245MG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCIH1299	CCLE Cell Line Gene Mutation Profiles	1.0	null
BRD-K24102129_-666_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
5-lipoxygenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.548
GTEX-POYW-0008-SM-48TE4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55759
Integration of energy metabolism	Reactome Pathways 2014	1.0	null
Disease	Reactome Pathways 2014	1.0	null
USE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07085
IST-SL1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Fast twitch muscle fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.109
superficial stratum of r5Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08082
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18041
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.858534
GTEX-S95S-1426-SM-2XCDM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878967
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.493
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14728
CCT8	Pathway Commons Protein-Protein Interactions	1.0	null
il6	GeneRIF Biological Term Annotations	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15995
Fruit juice	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.574
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
ERP44	Pathway Commons Protein-Protein Interactions	1.0	null
vastus lateralis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.874862
ULK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00513859
dorsal thalamus_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02314
Bhlha15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.8772
PRKCDBP	Pathway Commons Protein-Protein Interactions	1.0	null
GSE92965_0_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
r4 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25281
imatinib_homo sapiens_gpl96_gds3045	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GFPT1	Pathway Commons Protein-Protein Interactions	1.0	null
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.14937
BRD-K33503286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12238
Benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.015
ACACA	Pathway Commons Protein-Protein Interactions	1.0	null
GSE138024_2_v_3_rgs4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.569
PMC11385366-Table2.xlsx-DBP-Overlapped_Gene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K15160749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16939
GTEX-RWSA-0008-SM-47JYX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.984808
SMC6	Pathway Commons Protein-Protein Interactions	1.0	null
NEUROG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10669
Biotin	DrugBank Drug Targets	1.0	null
CCT7	Pathway Commons Protein-Protein Interactions	1.0	null
A549_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172532
heart	Phosphosite Textmining Biological Term Annotations	1.0	null
GSE152441,GSE152442_6_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6986-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE182680,GSE182683_10_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one	CTD Gene-Chemical Interactions	1.0	null
TOV-112D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.98318
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.854524
NCI-H2795	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.1142
PRG4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K50234570_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.515
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.2962
BRD-K02793474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61864
PMC10111863-supp_gad.350269.122_Supplemental_Paun350269_FileS3.xlsx-A_ASCL1-regulated_DGE-geneID_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Rucaparib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.025149
Posterior limiting nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30105
GTEX-PWN1-0226-SM-2S1OZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64358
forelimb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.901147
BRD-K91615044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26112
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
NRD1	Pathway Commons Protein-Protein Interactions	1.0	null
JHOC5	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52955
myotube	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.00894
placenta_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.87571
JHOM1	DepMap CRISPR Gene Dependency	1.0	2.49983
MAP3K5	Pathway Commons Protein-Protein Interactions	1.0	null
adrenal gland	HPA Tissue Gene Expression Profiles	1.0	0.842391
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BRD-A19500257_geldanamycin_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lateral septal nucleus, caudal (caudodorsal) part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25796
CTR9	Pathway Commons Protein-Protein Interactions	1.0	null
non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.079
GSE144231_2_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	2.46258
DDX43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38033
GTEX-XAJ8-0926-SM-47JXZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0777
Perturb_11199_KD_Scap_SRP311091	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
BRD-K96799727_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
type 2 diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.748359
SMARCA5	Pathway Commons Protein-Protein Interactions	1.0	null
digestive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
RERF-LC-FM	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ML-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.74063
mantle zone of PThE	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13031
AdrenalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.22219
MCF7_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0109127
calcium	Phosphosite Textmining Biological Term Annotations	1.0	null
HCC2302	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00152
ETV6	Pathway Commons Protein-Protein Interactions	1.0	null
organic cyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
TUBA4A	Pathway Commons Protein-Protein Interactions	1.0	null
HCC1428	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.733299
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0698
GSE228727_2_v_0_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Nodulus (X), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.51833
PMC9038526-mmc1.xlsx-postCOVID_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22194
BRD-K81418486_vorinostat_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RPL26L1	Pathway Commons Protein-Protein Interactions	1.0	null
ATP	MW Enzyme Metabolite Associations	1.0	null
BRD-K31843556_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE153124_4_v_0_dsg2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.25785
PKM	Pathway Commons Protein-Protein Interactions	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08855
BRD-A11007541_B4313_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE149769_1_v_0_nlrp12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K57271749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0108
PMC6861325__F4	PFOCR Pathway Figure Associations 2024	1.0	null
GSE89767_1_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X8HC-0226-SM-4E3K1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.96193
Lipidoses	CTD Gene-Disease Associations	1.0	1.01474
imatinib_homo sapiens_gpl96_gds3048	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ribonucleoside binding	GO Molecular Function Annotations 2015	1.0	null
Soleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.791
HOXA10	Pathway Commons Protein-Protein Interactions	1.0	null
Anterolateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05795
bj	HPA Cell Line Gene Expression Profiles	-1.0	-0.846531
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.793959
496100485_PCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.14509
alpha-ergocryptine-3900	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC6628043__F7	PFOCR Pathway Figure Associations 2024	1.0	null
lipid metabolic process	GO Biological Process Annotations 2015	1.0	null
obesity	GeneRIF Biological Term Annotations	1.0	null
Ire1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.146
GTEX-X261-0326-SM-3NMD4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12752
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.912
GSE96649_1_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K44932450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24346
SREBF1	ChEA Transcription Factor Targets	1.0	null
PRKAB2	Pathway Commons Protein-Protein Interactions	1.0	null
inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.849048
Prostate adenocarcinoma_PRAD_TCGA-EJ-7794-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
indian	GeneRIF Biological Term Annotations	1.0	null
GSE179974_3_v_4_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0104774
SEC16A	Pathway Commons Protein-Protein Interactions	1.0	null
Intracranial Hypertension	CTD Gene-Disease Associations	1.0	1.01025
co-dergocrine mesilate-2793	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K67439147_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SKNMC	CCLE Cell Line Gene Expression Profiles	1.0	1.99167
inhibitor	GeneRIF Biological Term Annotations	1.0	null
Hyperlipidemias	CTD Gene-Disease Associations	1.0	2.03198
TEN	CCLE Cell Line Gene Mutation Profiles	1.0	null
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14504
C4A	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6429383__F7	PFOCR Pathway Figure Associations 2024	1.0	null
496100574_HIP_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.33666
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5971-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CCT2	Pathway Commons Protein-Protein Interactions	1.0	null
limb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.882474
PMC12069319-Table1.xlsx-OCAB_p34_BirA-Gene_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
T-T	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MHH-ES-1	GDSC Cell Line Gene Expression Profiles	1.0	3.15378
GSE125007,GSE125008_1_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ankylosing Spondylitides_macrophage_GSE11886	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.36085
Drug Hypersensitivity	CTD Gene-Disease Associations	1.0	1.35012
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4324
recombinant	GeneRIF Biological Term Annotations	1.0	null
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ebl	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.548
USP10	Pathway Commons Protein-Protein Interactions	1.0	null
Hypoglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.503
PMC10773028-40364_2023_552_MOESM2_ESM.xlsx-Variants_sheet-TFT_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152441,GSE152442_6_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.8798
DACT1	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2099
BRD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01949
ATRFLOX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
nitric-oxide-synthase-type-iii	Phosphosite Textmining Biological Term Annotations	1.0	null
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.890525
PMC10746608-427_2023_709_MOESM5_ESM.xlsx-NR3C1_partners-NR3C1_known_protein_partners_according_to_BioGrid_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A13650332_Flucloxacillin sodium_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QLQ7-1526-SM-2S1QA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47518
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23342
GSE200673,GSE200691_2_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
phosphorylated	GeneRIF Biological Term Annotations	1.0	null
nucleus	LOCATE Curated Protein Localization Annotations	1.0	null
GSE178532_2_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
AHNAK	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH23	CCLE Cell Line Gene Mutation Profiles	1.0	null
A549_Costunolide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193564
preadipocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.415434
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cytokine	GeneRIF Biological Term Annotations	1.0	null
GTEX-P4PQ-1726-SM-3NB15	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878647
GSE178714_5_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
tonsil_8e1	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.866342
Abdominal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.439
Muscle myosin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.623
HGC-27	COSMIC Cell Line Gene Mutation Profiles	1.0	null
dihydroergotamine-4502	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Lung Neoplasms	CTD Gene-Disease Associations	1.0	1.55971
abnormal glycogen level	MPO Gene-Phenotype Associations	1.0	null
Dermatitis	CTD Gene-Disease Associations	1.0	1.16666
GSE62843,GSE64371_4_v_0_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
plastid	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.01933
primary motor cortex (area M1, area 4)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.20544
diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.331272
GTEX-U8XE-1426-SM-3DB8Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952299
MCF 10A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
SUCLG1	Pathway Commons Protein-Protein Interactions	1.0	null
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE168602,GSE168604_2_v_6_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SACS	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K82187446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80443
Human - Adipose - L1 - Adipocyte	HuBMAP Azimuth Cell Type Annotations	1.0	null
SUIT2	DepMap CRISPR Gene Dependency	1.0	2.27367
GSE216538_7_v_6_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
acacb	GeneRIF Biological Term Annotations	1.0	null
GATA3-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
abnormal circulating ketone body level	MPO Gene-Phenotype Associations	1.0	null
GSE144231_6_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TKQ1-1426-SM-4GICK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34462
ZNF354B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K29582115_Z2777_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K88510285_B675700.cdx_SW620_6.0_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Ebolavirus(ZEBOV)_3day_Spleen_None_GSE57214	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.47962
PMC5903287-NIHMS956886-supplement-Table_2.xls-THP1_THP3_cds_exp_down-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD	Reactome Pathways 2014	1.0	null
BRD-K89767945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04947
confers	GeneRIF Biological Term Annotations	1.0	null
BRD-K03736784_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SCS214	DepMap CRISPR Gene Dependency	1.0	3.69993
ranolazine_mus musculus_gpl1261_gse25767	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RPL17	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_downregulated_genes-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.046495
NCIH2009	CCLE Cell Line Gene Mutation Profiles	1.0	null
ADP	MW Enzyme Metabolite Associations	1.0	null
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0511
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13415
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Dasatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154091
intermediate-density lipoprotein particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.597
PML	Pathway Commons Protein-Protein Interactions	1.0	null
GSE229580_2_v_3_creb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Anemia, Hemolytic	CTD Gene-Disease Associations	1.0	1.39702
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A13J-11A-13R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE218907_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
organic acid transmembrane transport	GO Biological Process Annotations 2015	1.0	null
Inflammation	HuGE Navigator Gene-Phenotype Associations	1.0	null
Retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
CYB5R3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00741
glycosyl compound metabolic process	GO Biological Process Annotations 2015	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MB-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1666	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.65924
BRD-K55940699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21653
Reflex, Abnormal	CTD Gene-Disease Associations	1.0	1.7181
YMB1	CCLE Cell Line Gene Expression Profiles	1.0	1.38223
presubiculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42753
BRD-K71103788_DULOXETINE HYDROCHLORIDE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mRNA_NANOG_16767105	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01567
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.563
acid	GeneRIF Biological Term Annotations	1.0	null
BRD-K06418332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01764
primary auditory cortex (core)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16147
Prostate adenocarcinoma_PRAD_TCGA-HC-7738-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9532
cingulate gyrus, retrosplenial part, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.965371
BRD-K39985369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00387
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5711-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
olivary pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01847
BRD-A81407814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21553
BRD-K50140147_NVP-TAE684_HME1_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K76628522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51377
Ataxia	CTD Gene-Disease Associations	1.0	1.52642
A549_AMG-900_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.011379
GTEX-XMD1-0008-SM-4AT41	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.961885
GSE153137,GSE153140_2_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.482
Oxoglutarate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.893
OVMANA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.89039
GSE215351,GSE215794_1_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrial pyruvate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.676
hsa-miR-544	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.42346
CTCF	ENCODE Transcription Factor Targets	1.0	null
BRD-K99609051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2916
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11B-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K71631414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11137
DIP2B	Pathway Commons Protein-Protein Interactions	1.0	null
glycogen storage disease v	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.936214
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.519647
HCC2218	CCLE Cell Line Gene Expression Profiles	1.0	2.85403
CTBP1	Pathway Commons Protein-Protein Interactions	1.0	null
GATA1-19941827-MEL86-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
decamethonium bromide-4174	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
positive regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
lowintensity	GeneRIF Biological Term Annotations	1.0	null
water-soluble vitamin metabolic process	GO Biological Process Annotations 2015	1.0	null
HUPT4	CCLE Cell Line Gene CNV Profiles	1.0	1.92832
Rad51B-Rad51C complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.533
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.31539
BRD-K17315445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88278
Cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.243
bundle sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.448731
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3440-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K94992087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04074
Status Epilepticus	CTD Gene-Disease Associations	1.0	1.04538
GTEX-NL3H-0008-SM-4E3HU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2345
PMC9380317-13045_2022_1327_MOESM3_ESM.xlsx-Table_S4-Table_S4_Top_500_differentially_modified_gene_bodies_between_AA_and_EA_patients_with_MM_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
medial geniculate complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.985524
organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
TOV112D	CCLE Cell Line Gene Expression Profiles	1.0	1.51432
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
NBSUSSR	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KNS-81-FD	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-6146-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1437	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-S7SF-1826-SM-3K2AD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10829
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02843
sirolimus-5567	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K58863194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09723
organic substance biosynthetic process	GO Biological Process Annotations 2015	1.0	null
TNIP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00574099
Bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
humans	GeneRIF Biological Term Annotations	1.0	null
TUBA1B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K51323894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87565
Lung squamous cell carcinoma_LUSC_TCGA-56-7222-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE98831_1_v_0_brca1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mesophyll	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.91
GSE180200,GSE180201_2_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K90999434_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91948
metabolic syndrome	GAD Gene-Disease Associations	1.0	null
WDR37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37091
PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Hesperadin_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00911259
CTV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.218374
GSE205070_2_v_7_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K98529522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.30858
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6087-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC3376834-emmm0004-0052-SD2.xlsx-NR2E3_Specific_1847-Unnamed_1_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
Bile canaliculus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.536
plasma lipoprotein particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.119776
seed	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.342971
commensal bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.114097
plant form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.53267
intermediate stratum of IC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28729
PITX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.9729
KLF1-20508144-FETAL-LIVER-ERYTHROID-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-UJMC-0008-SM-4IHKK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08232
Rectum adenocarcinoma_READ_TCGA-AH-6643-11A-01R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE157050,GSE157051_2_v_9_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TBX3-20139965-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.32975
MDAMB415	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.0924
DDX17	Pathway Commons Protein-Protein Interactions	1.0	null
breast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057065
Azotemia	CTD Gene-Disease Associations	1.0	1.26267
HSPA5	Pathway Commons Protein-Protein Interactions	1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.615
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
CRCGN011_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30347
ANKRD44	Pathway Commons Protein-Protein Interactions	1.0	null
NAIP	Pathway Commons Protein-Protein Interactions	1.0	null
SELENOW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58535
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5705-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary somatosensory area, barrel field, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01491
UAMC00039	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952087
mediodorsal nucleus of thalamus_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04708
type 2 diabetes	GAD Gene-Disease Associations	1.0	null
Anorexia	CTD Gene-Disease Associations	1.0	1.56582
PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7--Target_name_PAX7	Rummagene Transcription Factor Associations 2026	1.0	null
Tachycardia, Ventricular	CTD Gene-Disease Associations	1.0	1.06808
BRD-K05137000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1746
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3443-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STK33_knockdown_50_GSE15151	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.32234
BRD-K93123848_RAF 265_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K60230970_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC4777381-pone.0150624.s007.xlsx-dif_exp_AD-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
nih-3t3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.18732
Parasubiculum, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13455
Hepatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.3
Anemia	CTD Gene-Disease Associations	1.0	1.32251
GP1BB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00644619
GTEX-PLZ6-1326-SM-3NB24	GTEx Tissue Sample Gene Expression Profiles	1.0	2.38878
RPLP2	Pathway Commons Protein-Protein Interactions	1.0	null
Stomach	GTEx Tissue Gene Expression Profiles 2023	1.0	2.20323
GSE48812_3_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
lateral parabrachial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.23721
Feather vane	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.632
BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Skeletal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.484
NCI-H1648	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PITX2	Pathway Commons Protein-Protein Interactions	1.0	null
RT-112	COSMIC Cell Line Gene Mutation Profiles	1.0	null
abnormal lipid level	MPO Gene-Phenotype Associations	1.0	null
low-density lipoprotein particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.961
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22069
abnormal white adipose tissue amount	MPO Gene-Phenotype Associations	1.0	null
Heart Diseases	CTD Gene-Disease Associations	1.0	2.05055
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
regulation of lipid metabolic process	GO Biological Process Annotations 2015	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.33735
Perturb_11198_KD_Pten/Scap_SRP311091	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
IM-95	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K39580048_arg-a1-2 BRD-K39580048_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZR7530	CCLE Cell Line Gene Expression Profiles	1.0	1.67199
NCI-H1693	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_10609_KO_Rbm20_SRP124759	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.64119
BRD-K35520972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00662
Nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
provide	GeneRIF Biological Term Annotations	1.0	null
endomembrane system	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
HCC202	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.765225
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE	Reactome Pathways 2014	1.0	null
CEBPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6477
BRD-K89732114_trifluoperazine_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
fat_x1.V2	HPA Tissue Sample Gene Expression Profiles	1.0	3.03252
MSMO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50935
PEX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28077
Lung squamous cell carcinoma_LUSC_TCGA-22-5482-11A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDC26	Pathway Commons Protein-Protein Interactions	1.0	null
NEK4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A59985574_T542500_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MCC13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE92965_0_v_1_klf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MRPL18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56026
GTEX-T6MO-0326-SM-32QOK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65996
SLC25A10	Pathway Commons Protein-Protein Interactions	1.0	null
MDAMB415	CCLE Cell Line Gene Expression Profiles	1.0	1.44506
GSE230656_0_v_1_gsdmd_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCT15	CCLE Cell Line Gene Mutation Profiles	1.0	null
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-U41416256_THZ-2-98-01_MDAMB231_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EMD	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF263	ChEA Transcription Factor Targets	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HF-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fluvastatin-3370	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7582-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K87689816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00031
CHAF1B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K71537579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11022
BRD-K02130563_S1030_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Hypospadias	CTD Gene-Disease Associations	1.0	1.01587
Lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.387
A549_Iniparib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141471
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.25457
ventrolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.24215
A549_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153191
15548371-Table3	GeneSigDB Published Gene Signatures	1.0	null
GTEX-XLM4-0226-SM-4AT4N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01752
BRD-K05649647_-666_A549_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K06261202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00755
Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.81502
Bile duct disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
NCIH841	CCLE Cell Line Gene Expression Profiles	1.0	1.36809
molsidomine-2862	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE196117_6_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Adipose - Subcutaneous	GTEx Tissue Gene Expression Profiles 2023	1.0	3.68247
GSE135030_8_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JAK1_druginhibition_165_GSE38335	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-3.30393
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933067
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.661
gallbladder	HPA Tissue Protein Expression Profiles	1.0	1.16855
TACC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41984
lateral hypothalamic area, tuberal region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.23835
mouse	Phosphosite Textmining Biological Term Annotations	1.0	null
haloperidol-1539	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03458
GTEX-W5X1-1426-SM-3GIKH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05527
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.878791
Pancreatic islet cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.697
Prelimbic area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18684
pc3	HPA Cell Line Gene Expression Profiles	1.0	2.12257
D-336MG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ETV3	Pathway Commons Protein-Protein Interactions	1.0	null
cellular aromatic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
Perturb_10810_KO_Xbp1_SRP262377	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.83737
a549	HPA Cell Line Gene Expression Profiles	1.0	0.92514
DMS53	CCLE Cell Line Gene CNV Profiles	1.0	1.37849
PLA2G4A	Pathway Commons Protein-Protein Interactions	1.0	null
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.58546
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PPP2R1B	Pathway Commons Protein-Protein Interactions	1.0	null
SLC27A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00401535
spi1_17041602_preleukemic_hscs_lof_mouse_gpl1261_gds2411	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.117697
KARPAS1718	DepMap CRISPR Gene Dependency	1.0	3.03343
RS4-11	COSMIC Cell Line Gene Mutation Profiles	1.0	null
abnormal glucose homeostasis	MPO Gene-Phenotype Associations	1.0	null
GSE255680_2_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
posteroventral (inferior) parietal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.921061
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Vastus lateralis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.61
adipose tissue	GTEx Tissue Gene Expression Profiles	1.0	1.56084
protein binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K45092891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09619
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.839822
SYK_druginhibition_152_GSE34176	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.06555
protein oligomerization	GO Biological Process Annotations 2015	1.0	null
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.18652
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.469
Hepatoma HLE cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.757
Lingula (I), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.40372
Mental Depression	DisGeNET Gene-Disease Associations	1.0	null
substantia nigra, pars reticulata, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.29884
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
superficial stratum of r6Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09788
GSE210842_3_v_1_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H2AFZ	Pathway Commons Protein-Protein Interactions	1.0	null
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.51751
decreased body size	MPO Gene-Phenotype Associations	1.0	null
mantle zone of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42753
cardiac muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.382131
acc	GeneRIF Biological Term Annotations	1.0	null
SUP-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
complete	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-3064-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3BZ-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
atp binding	GO Molecular Function Annotations 2015	1.0	null
Perturb_10812_KO_Xbp1_SRP262377	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.95524
Respirasome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.872
catalytic complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.061317
Hypopharyngeal Cancer	DisGeNET Gene-Disease Associations	1.0	null
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31888
cardiovascular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SNU-484	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.955553
KARPAS-1106P	COSMIC Cell Line Gene Mutation Profiles	1.0	null
protein complex subunit organization	GO Biological Process Annotations 2015	1.0	null
GTEX-OXRL-0226-SM-3NB18	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18503
NFIL3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.248
TLR9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00566224
Defects in biotin (Btn) metabolism	Reactome Pathways 2014	1.0	null
GTEX-R55G-2326-SM-2TC61	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15122
MCF10DCIS.COM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.92782
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.45886
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.343
epitrochlearis muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.413151
LIVF001-009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4211
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BF-11A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE196699_2_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7730-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PCGF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41935
GSE210885_2_v_4_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11171
abnormality of the endocrine system	GWASdb SNP-Phenotype Associations	1.0	0.085955
NCIH1623	CCLE Cell Line Gene Mutation Profiles	1.0	null
LU-165	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Diabetic Nephropathies	HuGE Navigator Gene-Phenotype Associations	1.0	null
Leukemia_chronicMyelogenousK-562	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.943721
GSE202434,GSE202438_7_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02325
outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49018
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A76490030_K784-3131_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NPR1	Pathway Commons Protein-Protein Interactions	1.0	null
globus pallidus, external segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.830791
ERBB2_knockdown_235_GSE8373	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.7106
BRD-K55538850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15245
Brain Edema	CTD Gene-Disease Associations	1.0	1.33909
Perturb_1716_KO_Fubp1_SRP174350	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.65985
DDX24	Pathway Commons Protein-Protein Interactions	1.0	null
COLO783	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.23154
BRD-K61943321	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63353
SNX19	Pathway Commons Protein-Protein Interactions	1.0	null
Melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.007
PMC10769314-NIHMS1954782-supplement-9.xlsx-Table_S7B-Table_S7B_Frontal_cortex_relative_gene_expression_from_post-KD_and_pre-KD_recipient_mice_AR	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
lkb1	Phosphosite Textmining Biological Term Annotations	1.0	null
cation transmembrane transport	GO Biological Process Annotations 2015	1.0	null
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.791939
PMC8212145__F5	PFOCR Pathway Figure Associations 2024	1.0	null
PMC6429383__F7	PFOCR Pathway Figure Associations 2023	1.0	null
Skeletal muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.573
organic acid binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K22193694_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
relative	GeneRIF Biological Term Annotations	1.0	null
GSE149880_0_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
aromatic compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Hypertriglyceridemia	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE196962_4_v_6_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
increased circulating ketone body level	MPO Gene-Phenotype Associations	1.0	null
GSE120413,GSE120447_4_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MIA PACA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K20755323_-666_SKMEL28_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE180185_7_v_5_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IMMT	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K37684893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03927
GSE164874_5_v_13_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KYSE-510	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
A549_Decitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158772
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YN-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Down_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
outer SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01801
MDA-MB-453	COSMIC Cell Line Gene Mutation Profiles	1.0	null
abnormal gas homeostasis	MPO Gene-Phenotype Associations	1.0	null
Liver enzyme levels (alkaline phosphatase)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.70458
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Arsenic	CTD Gene-Chemical Interactions	1.0	null
PPP6R1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE216273,GSE216292_14_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZC3H7B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A19500257_geldanamycin_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COUP direct repeat 1	MotifMap Predicted Transcription Factor Targets	1.0	null
MEWO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Perturb_10872_KO_fatp2_SRP229353	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.73798
JHUEM1	CCLE Cell Line Gene Mutation Profiles	1.0	null
MAX	Pathway Commons Protein-Protein Interactions	1.0	null
Brown adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.381
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6088-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PANC0327	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39902
Perturb_789_KD_Foxk2_SRP145105	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.57882
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
LIMS1	Pathway Commons Protein-Protein Interactions	1.0	null
Diabetes Mellitus, Type 2	HuGE Navigator Gene-Phenotype Associations	1.0	null
expresses	GeneRIF Biological Term Annotations	1.0	null
mRNA_ESRRB_16767105	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
HNRNPU	Pathway Commons Protein-Protein Interactions	1.0	null
A549_PFI-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138938
GTEX-U3ZH-0008-SM-4DXT2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890357
ATP6V1E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05607
PAX2	JASPAR Predicted Transcription Factor Targets	1.0	null
abnormal circulating glucose level	MPO Gene-Phenotype Associations	1.0	null
GSE203072_2_v_3_rpl3l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BT-483	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07497
KPL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.05099
BRD-A42649439_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CEBPB	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K73395020_ARP 101_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Primary somatosensory area, barrel field	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14153
PPP2R1A	Pathway Commons Protein-Protein Interactions	1.0	null
purine nucleoside metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-R53T-1526-SM-48FEK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982776
organic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
DNAH8	Pathway Commons Protein-Protein Interactions	1.0	null
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4989
SK-MEL-5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51164
PMC9287735-mmc8.xlsx-MI_Related_Genes-TNF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
carnitine transport	GO Biological Process Annotations 2015	1.0	null
BRD-A75478957_PD 166793_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prestwick-674-4276	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HEC251	CCLE Cell Line Gene Mutation Profiles	1.0	null
decreased fatty acids level	MGI Mouse Phenotype Associations 2023	1.0	null
PREX2	Pathway Commons Protein-Protein Interactions	1.0	null
RBFA	Pathway Commons Protein-Protein Interactions	1.0	null
orphenadrine-3801	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
decreased circulating glucose level	MPO Gene-Phenotype Associations	1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.36695
Collagen trimer	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.64
GTEX-QVUS-0008-SM-447AY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10965
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824902
glycogen storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.559062
PMC6870463-Table_7.xlsx-Family_H_No_LPS-Untreated_BMDMs_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
rat	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16847
GSE124410_3_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IL13	MSigDB Cancer Gene Co-expression Modules	1.0	null
Thrombosis	CTD Gene-Disease Associations	1.0	1.51255
IM-95M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.914736
BRD-K77286328_R3904_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE95077_5_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DDX47	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2008
UBE2N	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27008
PMC12513837-41588_2025_2336_MOESM4_ESM.xlsx-Supplementary_Table_1-Supplementary_Table_1_List_of_AR-only_and_p300_AR-shared_enhancer_regulated_genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE115364_0_v_1_idh3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Muscle fibre	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.901
CRCGN015_HEPG2_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.17269
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03486
PMC5444746-oncotarget-08-30328-s002.xlsx-SI01_ChIPSeq_H3K9me_AR-Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NG-A4VU-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Phosphoric acid	HMDB Metabolites of Enzymes	1.0	null
BRD-A25736793_everolimus_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
seedling	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.579216
GSE180185_7_v_10_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BJHTERT	CCLE Cell Line Gene CNV Profiles	-1.0	-3.20992
Posterior cingulate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.671
Carbonic acid	HMDB Metabolites of Enzymes	1.0	null
Excretory gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
KYSE-220	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7943
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.97196
Mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.135
r5 part of ventral lateral lemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09038
Acidosis	CTD Gene-Disease Associations	1.0	1.20196
GSE174383_2_v_0_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.41015
GTEX-PX3G-0008-SM-48U2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35048
androstadienes	Phosphosite Textmining Biological Term Annotations	1.0	null
GSE223893_1_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
periventricular stratum of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28818
regulation of fatty acid oxidation	GO Biological Process Annotations 2015	1.0	null
Barrington's nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18963
HSD17B4	Pathway Commons Protein-Protein Interactions	1.0	null
SNU-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.857915
lkb1	GeneRIF Biological Term Annotations	1.0	null
ETV5::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.56
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5024
decreased body weight	MGI Mouse Phenotype Associations 2023	1.0	null
peroxisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.65259
Pre-ATP-grasp domain	InterPro Predicted Protein Domain Annotations	1.0	null
CRO-AP2	GDSC Cell Line Gene Expression Profiles	-1.0	-1.70262
Perturb_17775_OE_Tgfb1_SRP325964	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.99074
SG in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.908337
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.945538
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7923-01A-12R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VEGFA VEGFR2 signaling	WikiPathways Pathways 2024	1.0	null
GSE158834_11_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.175399
GSE188870,GSE188871_4_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
anterior nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.56168
decreased circulating free fatty acids level	MGI Mouse Phenotype Associations 2023	1.0	null
PMC5819186-13040_2018_163_MOESM3_ESM.xlsx-Lung-TCF21_TCF21	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7617064-EMS151900-supplement-Extended_Data_Figure_7_Source_Data.xlsx-D23_RORC-Logfold_change_threshold_1_0_1_RORC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE132386_1_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PPP1R1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08718
plastid part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.273734
GSE103068_0_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10337103-13046_2023_2747_MOESM2_ESM.pdf-3-IRF7_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
CMK115	CCLE Cell Line Gene Mutation Profiles	1.0	null
GTEX-XGQ4-2226-SM-4AT4Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33445
regulation of multicellular organismal development	GO Biological Process Annotations 2015	1.0	null
SW 900	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
EKVX	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.888157
Mitochondrial Diseases	CTD Gene-Disease Associations	1.0	1.28088
GSE152246_0_v_1_dihydrotestosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K78167523_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
1,5-isoquinolinediol-543	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RAG1	Pathway Commons Protein-Protein Interactions	1.0	null
signal	Phosphosite Textmining Biological Term Annotations	1.0	null
superficial stratum of PaS (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40658
Presubiculum, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43182
purine ribonucleotide metabolic process	GO Biological Process Annotations 2015	1.0	null
Heart	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Pauciarticular juvenile arthritis_Peripheral blood mononuclear cell_GSE1402	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.0396
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E8-11A-12R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K33495825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10898
PMC11024925-mmc3.xlsx-Gene_lists-MV411_FOS_ChIP_and_RNA_overlap_after_10_nM_Gilteritinib_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
carboxylic acid transport	GO Biological Process Annotations 2015	1.0	null
GTEX-XYKS-0008-SM-4BRW6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827048
BRD-K44713204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16765
phosphates	Phosphosite Textmining Biological Term Annotations	1.0	null
extensor digitorum longus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.07
weight	Phosphosite Textmining Biological Term Annotations	1.0	null
REST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00499391
CAMTA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25885
BXPC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.70936
muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055295
BRD-K92180676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89762
anteroventral nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05185
abnormal circulating insulin level	MPO Gene-Phenotype Associations	1.0	null
GSE178340_7_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hypertriglyceridemia	CTD Gene-Disease Associations	1.0	1.91993
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.963797
cell part	GO Cellular Component Annotations 2015	1.0	null
mantle zone of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40658
Peripheral Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.67569
TMPRSS11A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE110440_2_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
peritoneal cavity	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.411251
UBR5	Pathway Commons Protein-Protein Interactions	1.0	null
A549_MK-5108_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172795
basomedial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.899564
18310505-TableS6	GeneSigDB Published Gene Signatures	1.0	null
BRD-A21858158_PRAZIQUANTEL_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_2595_KD_SMURF1_SRP115428	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
posterior (caudal) superior temporal cortex (area 22c)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10555
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5452-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OOBJ-0008-SM-3NB26	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.87696
GSE201309_4_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
DOTC2-4510	COSMIC Cell Line Gene Mutation Profiles	1.0	null
adrenal_4a	HPA Tissue Sample Gene Expression Profiles	1.0	0.912151
GSE202134_0_v_1_rbm39_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2840-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Adenine	DrugBank Drug Targets	1.0	null
GSE154464_1_v_3_cdk6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02448
primary auditory cortex (core)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.88161
genotypes	GeneRIF Biological Term Annotations	1.0	null
HDQP1_BREAST	CCLE Cell Line Proteomics	1.0	10.0661
GSE129858,GSE129859_1_v_3_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.93561
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.244
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A1H6-01B-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HSF1-23293686-STHDH_STRIATAL-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.928045
BRD-K92301463_-666_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ml94	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.823
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054409
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.5415
BRD-A63998256_Helveticoside_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pancreatic islet	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.171805
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.86075
Sacrospinalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.574
glial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.084834
Prestwick-1083-2976	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.532
GM12878	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.984467
primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26515
kinase	GeneRIF Biological Term Annotations	1.0	null
promotion	GeneRIF Biological Term Annotations	1.0	null
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.49159
GSE157594_0_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
IL18 signaling	WikiPathways Pathways 2024	1.0	null
r9 portion of ambiguous motor nucleus (postmigratory)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.90067
GSE188869,GSE188871_2_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pruritus	CTD Gene-Disease Associations	1.0	1.7625
HCC2279	CCLE Cell Line Gene Mutation Profiles	1.0	null
SIX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8908
BRD-K56653679_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1163
Biceps femoris	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.645
NRF2-31884422-A549-HUMAN-LUNG-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K15607890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48903
r5 part of the oral Sp5 subnucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0804
GSE70499_4_v_1_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KNS81	Achilles Cell Line Gene Essentiality Profiles	1.0	1.0553
BRD-A09828896_SKF 81297 hydrobromide_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K68143200_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE182075_3_v_1_btn1a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
sternum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.223419
positive regulation of multicellular organismal process	GO Biological Process Annotations 2015	1.0	null
BRD-K68060538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22852
p3h3	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.634
Intermediodorsal nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11804
intermediate stratum of m1AL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07311
GSE132948,GSE132949_0_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mantle zone of VTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41279
CML-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07387
Gfi1b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.9779
r1 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.34817
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14942
BRD-K66037923_NCGC00182390-01_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.82336
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12271
PCBP2	Pathway Commons Protein-Protein Interactions	1.0	null
CACNA1G	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K81656074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61297
pathways	GeneRIF Biological Term Annotations	1.0	null
primary auditory cortex (core)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.99575
MEWO	CCLE Cell Line Gene Mutation Profiles	1.0	null
CDR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14686
PPIP5K2	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-circARID1A_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE129725_4_v_0_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146074_9_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KRT85	Pathway Commons Protein-Protein Interactions	1.0	null
colforsin-7055	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2998-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer 3 of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01491
CAR-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00152
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.248
ELF1	ENCODE Transcription Factor Targets	1.0	null
comprised	GeneRIF Biological Term Annotations	1.0	null
GTEX-Q2AI-1426-SM-2S1P5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13165
Reperfusion Injury	CTD Gene-Disease Associations	1.0	1.24465
HT-144	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.971009
about	GeneRIF Biological Term Annotations	1.0	null
BRD-K68558540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86872
lowering	GeneRIF Biological Term Annotations	1.0	null
BRD-K25408656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3
A549_TMP195_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0224656
hsa-miR-125b	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
BRD-K24479270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35145
CEBPD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.0936
SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.64068
morphological	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEX-S4Q7-1626-SM-3K2AE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18577
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.32348
BRD-K45472595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02882
nucleoside phosphate biosynthetic process	GO Biological Process Annotations 2015	1.0	null
K562_Resminostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124694
Skeletal muscle fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.436
RUNX1-22343733-KASUMI1-HUMAN-PERIPHBLOOD-AML	ChEA Transcription Factor Targets 2022	1.0	null
glucocorticoid	GeneRIF Biological Term Annotations	1.0	null
intracellular part	GO Cellular Component Annotations 2015	1.0	null
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982859
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PTPRM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00501502
BAG2	Pathway Commons Protein-Protein Interactions	1.0	null
ATP5F1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00351881
Acute Lung Injury	CTD Gene-Disease Associations	1.0	1.07768
GSE125782_0_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
metabolic process	GO Biological Process Annotations 2015	1.0	null
Biotin transport and metabolism	Reactome Pathways 2014	1.0	null
BRD-K17868609_BRL 54443_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Hyperalgesia	CTD Gene-Disease Associations	1.0	1.4449
PMC4078240__F4	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K45734531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33419
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Adipocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.314
Biotin metabolism including IMDs	WikiPathways Pathways 2024	1.0	null
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.873471
GSE228181_2_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OTUD4	Pathway Commons Protein-Protein Interactions	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5J7-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bmi1_Deficiency_GDS4816_323_mouse_Primary lung cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
abnormal food intake	MPO Gene-Phenotype Associations	1.0	null
KANK2	Pathway Commons Protein-Protein Interactions	1.0	null
carboxylic acid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
17760805-SuppTableS3b	GeneSigDB Published Gene Signatures	1.0	null
Clear cell renal cell carcinoma pathways	WikiPathways Pathways 2024	1.0	null
BRD-K17176016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0268
Aflatoxin B1	CTD Gene-Chemical Interactions	1.0	null
Primary somatosensory area, barrel field, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33309
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.04623
pancreatic beta cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.289582
Perturb_9488_KD_Appbp2_SRP359770	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.253
BRD-K49865102_PD-0325901_MCF7_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Human - Adipose - L2 - hAd5	HuBMAP Azimuth Cell Type Annotations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A185-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OHPM-1626-SM-2HMK4	GTEx Tissue Sample Gene Expression Profiles	1.0	2.5742
GSE94849_6_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ATM	Pathway Commons Protein-Protein Interactions	1.0	null
SMC1A	Pathway Commons Protein-Protein Interactions	1.0	null
r7 part of the dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.3033
Ventricular Fibrillation	CTD Gene-Disease Associations	1.0	1.21695
ESC_V6.5_UP_LATE.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
Inferior colliculus, external nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12896
BRD-K73395020_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Neuromuscular Diseases	CTD Gene-Disease Associations	1.0	1.19345
fatty acid biosynthetic process	GO Biological Process Annotations 2025	1.0	null
Kidney Neoplasms	CTD Gene-Disease Associations	1.0	1.36933
LY2	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.690463
PMC12712253-12672_2025_4014_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_for_PC_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
periventricular stratum of r1Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36135
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09574
SKA1	Pathway Commons Protein-Protein Interactions	1.0	null
Intramuscular adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.844
fatty acid metabolic process	GO Biological Process Annotations 2015	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6797-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
canavanine-4782	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8309-11A-01R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE171837_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.092513
MITF_01_207	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.62228
abnormal lipid oxidation	MPO Gene-Phenotype Associations	1.0	null
GSE213588_8_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.22456
BRD-K47598052_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE133213_9_v_15_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PDE1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00661413
Mitochondrial inner membrane peptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.111
GEMIN5	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_10843_KO_Xbp1_SRP197108	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.22393
INSM1	Pathway Commons Protein-Protein Interactions	1.0	null
SREBP-SCAP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.132
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-P4QS-1726-SM-3NB1V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863947
GSE154074_1_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K10882151_BO2 (inhibits RAD51)_MCF7_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prenatal Injuries	CTD Gene-Disease Associations	1.0	1.71358
cardiovascular system phenotype	MPO Gene-Phenotype Associations	1.0	null
BRD-K21897482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13089
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.88838
GSE140965_2_v_3_mybpc3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
KYSE510	CCLE Cell Line Gene Mutation Profiles	1.0	null
skeletal system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
periventricular stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.95296
OGT	Pathway Commons Protein-Protein Interactions	1.0	null
GSE68156_3_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE243683_0_v_1_s100a16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.111
BRD-K03512847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32151
GSE165174,GSE165175_0_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158320,GSE183351_2_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
KMT2A	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-6595-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of cardiac morphology	GWASdb SNP-Phenotype Associations	1.0	0.647367
zonal layer of SC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39839
glycogen metabolism disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.558674
GSE122101,GSE122103_3_v_4_ssu72_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4755-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
quaternary ammonium group transport	GO Biological Process Annotations 2015	1.0	null
ammonium transport	GO Biological Process Annotations 2015	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-11A-13R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.86322
KDM2B-26808549-CHIP-SEQ-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
cellular component organization	GO Biological Process Annotations 2015	1.0	null
BRD-K46005840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17223
CAMA1	CCLE Cell Line Gene Expression Profiles	1.0	1.40939
OCI-AML5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.826972
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.91535
Growth Disorders	CTD Gene-Disease Associations	1.0	1.20196
BRD-K17140735_-666_RMUGS_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cardiovascular Diseases	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K29668683_BD 1063 dihydrochloride_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE112762,GSE112767_1_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EIF4ENIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27457
decreased circulating leptin level	MGI Mouse Phenotype Associations 2023	1.0	null
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.824682
parvicellular part of Lat	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37542
Hypothermia	CTD Gene-Disease Associations	1.0	1.02783
GSS	CCLE Cell Line Gene CNV Profiles	-1.0	-2.3514
GTEX-SE5C-2126-SM-4BRUJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13126
cotinine-1929	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K10207760_Lasalocid sodium salt_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC5342737-oncotarget-07-75235-s003.xls-match_19_10_2015_heartliver_nor-Supplementary_Table_2_MYC_interacting_genes_that_are_significantly_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
mt2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.05
candidate	GeneRIF Biological Term Annotations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46E-01A-31R-A250-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8482521-mmc10.xlsx-Upstreme_Regulators_48_hr_MLR-Unnamed_0_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
ampk	Phosphosite Textmining Biological Term Annotations	1.0	null
amp	Phosphosite Textmining Biological Term Annotations	1.0	null
GCT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC6078963-41467_2018_5311_MOESM9_ESM.xlsx-PPARD_CHIP_vs_RNA_CD34-PPARD_macrophages_Vs_RNA_CD34_OE_DEGs_PPARD	Rummagene Transcription Factor Associations 2026	1.0	null
mRNA_TCF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
CRCGN014_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.85997
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.983769
Perirenal adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.818
Parkinsonian Disorders	CTD Gene-Disease Associations	1.0	1.15391
prediabetic	GeneRIF Biological Term Annotations	1.0	null
GTEX-SNOS-0008-SM-4DM6I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65426
ZBED1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5554
BRD-K54606188_(+)-JQ1_HA1E_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
central nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.843704
CPM	Pathway Commons Protein-Protein Interactions	1.0	null
Cerebral Hemorrhage	CTD Gene-Disease Associations	1.0	1.35849
Perturb_224_KD_YBX3_SRP289565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.18272
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE147613_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE48812_0_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
connective tissue	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K68202742_trichostatin A_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE169334,GSE169336_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
liver_a	HPA Tissue Sample Gene Expression Profiles	1.0	0.923274
decreased subcutaneous adipose tissue amount	MGI Mouse Phenotype Associations 2023	1.0	null
HNRNPL	Pathway Commons Protein-Protein Interactions	1.0	null
YAP1-20516196-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K97588749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10522
BRD-K76703230_YM-155_H1299_6.0_h_0.310000002384_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NDUFA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14065
GSE213611_1_v_0_nuf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PRDX3	Pathway Commons Protein-Protein Interactions	1.0	null
metal ion binding	GO Molecular Function Annotations 2015	1.0	null
GSE153867_6_v_8_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PSMA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1513
lymphnode_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.831886
MATN4	Pathway Commons Protein-Protein Interactions	1.0	null
monocarboxylic acid biosynthetic process	GO Biological Process Annotations 2023	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A76K-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ENO1	Pathway Commons Protein-Protein Interactions	1.0	null
Nutritional deficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.422
Liver hepatocellular carcinoma_LIHC_TCGA-EP-A26S-11A-12R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Human - Adipose - L2 - hAd6	HuBMAP Azimuth Cell Type Annotations	1.0	null
BRD-K78169765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01116
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
A549_Luminespib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016242
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
HIST1H1D	Pathway Commons Protein-Protein Interactions	1.0	null
abnormal glucose homeostasis	MGI Mouse Phenotype Associations 2023	1.0	null
polyphagia	MPO Gene-Phenotype Associations	1.0	null
mitochondrial membrane	GO Cellular Component Annotations 2023	1.0	null
BRD-K98548675_Parthenolide_HCT116_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
paracentral lobule, posterior part, left, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.84733
diencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061603
HCE-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KARS	Pathway Commons Protein-Protein Interactions	1.0	null
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.242595
tenoxicam-4182	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COV362	Achilles Cell Line Gene Essentiality Profiles	1.0	1.21304
GSE221020,GSE221023_2_v_1_pten_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.51164
abnormal lipid homeostasis	MPO Gene-Phenotype Associations	1.0	null
PHF20	Pathway Commons Protein-Protein Interactions	1.0	null
Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K88510285_B675700.cdx_SKLU1_6.0_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE114690_2_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
indometacin-2377	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K28120222_Prestw-550_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ischemia	Phosphosite Textmining Biological Term Annotations	1.0	null
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00152
ribonucleotide metabolic process	GO Biological Process Annotations 2015	1.0	null
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.25845
BRD-K28168037_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K87909389_HY-10005_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SK-MEL-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Chloroplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.548
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47383
BRD-K47584662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62923
GTEX-SNOS-1526-SM-32PLW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22894
thr308	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48962
BRD-K88510285_B675700.cdx_MCF7_24.0_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NFIL3	Pathway Commons Protein-Protein Interactions	1.0	null
PPP1R9B	Pathway Commons Protein-Protein Interactions	1.0	null
HC-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.71911
GSE252857_1_v_3_prednisone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13667
BRD-K39498165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34558
HCC1419	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12043
NB5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EDC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44023
ganciclovir-5389	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25148
ribonucleoside bisphosphate biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Flower bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.647
GSE166920_6_v_1_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PCMT1	Pathway Commons Protein-Protein Interactions	1.0	null
IZ in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05356
BRD-K71345532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12411
Anorexia Nervosa	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K25269762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34726
Perturb_9485_KD_Appbp2_SRP359770	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
u266	HPA Cell Line Gene Expression Profiles	1.0	1.11961
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29M-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.637102
Connective tissue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GMNN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.60919
Nr1h2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.5653
BRD-K64553072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67066
MDST8	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47452
DSH1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D3REFED24h_1198_AR-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7405837__F7	PFOCR Pathway Figure Associations 2023	1.0	null
layer 2 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50189
IM95	CCLE Cell Line Gene Mutation Profiles	1.0	null
BRD-A86109770_Guggulsterone_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RCC-MF	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Regulation of cholesterol biosynthesis by SREBP (SREBF)	Reactome Pathways 2014	1.0	null
organic cyclic compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
pontine nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23478
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EK-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866792
protein homooligomerization	GO Biological Process Annotations 2025	1.0	null
HUP-T3	COSMIC Cell Line Gene CNV Profiles	1.0	4.51153
HCC70	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.31927
BL2442 (RNF4)	NURSA Protein Complexes	1.0	null
GSE203060_0_v_2_kdm4c_human	RummaGEO Gene Perturbation Signatures	1.0	null
TRIM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19063
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.967453
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
UM-UC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03583
protein homotetramerization	GO Biological Process Annotations 2015	1.0	null
MDAMB361	DepMap CRISPR Gene Dependency	1.0	2.1382
BRD-K68968009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22354
Organellar small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.621
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91169
liver cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.230656
MFAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41831
Lung squamous cell carcinoma_LUSC_TCGA-43-6773-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.196
abnormal body size	MPO Gene-Phenotype Associations	1.0	null
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-E2A_Pre-Pro-B-Cells_ChIP-seq_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
Chylomicron	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.615
synthase	Phosphosite Textmining Biological Term Annotations	1.0	null
occipital pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.57824
VZ in subgenual cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17906
GSE114992,GSE114993_7_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.28277
ARID4B	Pathway Commons Protein-Protein Interactions	1.0	null
CW-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.510092
purine ribonucleoside metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE120756_2_v_9_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.18816
Tubulin folding cofactor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.944
BRD-K29842194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27769
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
NUGC-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.921221
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.902952
GTEX-WHWD-0826-SM-3LK6R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18492
Myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
Bed nuclei of the stria terminalis, posterior division, strial extension	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23481
GSE221577_4_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K77399094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22841
cefapirin-3471	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
L6E9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.662
Immune stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.881
A549_PF-573228_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176508
cellular biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09146
BRD-K17903303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26648
increased fatty acid beta-oxidation	MGI Mouse Phenotype Associations 2023	1.0	null
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.92665
LRIG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.492
Perturb_10860_KO_Med13_SRP302233	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	17.1068
DMS454	CCLE Cell Line Gene CNV Profiles	1.0	1.57115
ETS1-22383799-G1ME-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K16733272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24941
lipid storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.18591
BRD-K54467766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2574
HTK	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52103
risk	GeneRIF Biological Term Annotations	1.0	null
MAP7	Pathway Commons Protein-Protein Interactions	1.0	null
GSE182680,GSE182683_0_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain derived neurotrophic factor BDNF signaling	WikiPathways Pathways 2024	1.0	null
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24251
Colon - Sigmoid	GTEx Tissue Gene Expression Profiles 2023	1.0	2.7379
abnormal consumption behavior	MPO Gene-Phenotype Associations	1.0	null
CAMA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.6144
Pheochromocytoma and Paraganglioma_PCPG_TCGA-XG-A823-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K64380616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0002
PLD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0066015
layer 6a of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.71222
ethambutol-1900	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
H3K79me2_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCCSTCK140	CCLE Cell Line Gene Expression Profiles	-1.0	-1.64039
Drug-Related Side Effects and Adverse Reactions	CTD Gene-Disease Associations	1.0	2.03573
HSPA1B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K02822062_CT-200783_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
UBTF	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4292	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_EC_CSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16412
MAVER1	DepMap CRISPR Gene Dependency	1.0	3.96625
PMC7405837__F7	PFOCR Pathway Figure Associations 2024	1.0	null
GSE125007,GSE125008_4_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100559_FWM_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.11646
BACH1-22875853-HELA-AND-SCP4-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
15257931-SuppTableA	GeneSigDB Published Gene Signatures	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2872-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K15600710_S1057_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K36730085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58358
Fish- and plant-related diet	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.23979
Primary somatosensory area, nose, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1359
EB2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.856843
MDS - Myelodysplastic syndrome_Bone marrow stem cell_GSE2779	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.57581
CAL51	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.62167
Mitochondrial isocitrate dehydrogenase complex (NAD+)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.998
Perturb_10811_KO_Xbp1_SRP197108	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.49162
hepg2	GeneRIF Biological Term Annotations	1.0	null
forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE88819_7_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125157_1_v_0_piceatannol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GR-ST	COSMIC Cell Line Gene Mutation Profiles	1.0	null
striatum_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.873925
CREB3L4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4362
RPS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99226
BRD-K68174511_torin-2_HA1E_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KRT2	Pathway Commons Protein-Protein Interactions	1.0	null
regulation of growth	GO Biological Process Annotations 2015	1.0	null
TT	CCLE Cell Line Gene Mutation Profiles	1.0	null
layer 6a of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.72849
telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
MRPL38	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9692021-Table_4.xlsx-Table_S4-Table_S4_405_DEGs_of_RA_synovial_tissues_between_NFIL3-high_and_NFIL3-low_group_NFIL3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WY7C-2526-SM-3NB2N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37513
renal	GeneRIF Biological Term Annotations	1.0	null
BRD-K31606237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45981
Glutathione synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.535
PDHA2	Pathway Commons Protein-Protein Interactions	1.0	null
hydroxyachillin-2157	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1748
KRT78	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K02637850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.49319
HEY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01564
GSE158834_11_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-PWCY-0008-SM-48TE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.978976
BRD-K24471810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4475
hsa-miR-4755-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
SRF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4562
organophosphate metabolic process	GO Biological Process Annotations 2015	1.0	null
diazoxide-2052	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
sirolimus_homo sapiens_gpl2895_gse16944	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-5670-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7708794-mmc2.xlsx-DGE_table_Imm-high_vs_Imm-low-TFT_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
ERF::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0231
Medial preoptic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32233
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D4REFED48h_750_AR--Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30173809	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05123
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16068
Pancreatic Ductal Adenocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE210885_2_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BPTF	Pathway Commons Protein-Protein Interactions	1.0	null
GSE213048_1_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210885_0_v_4_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hypertension, Portal	CTD Gene-Disease Associations	1.0	1.08372
GSE131649_4_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE100732,GSE100733_0_v_1_lrpprc_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.989486
Lung squamous cell carcinoma_LUSC_TCGA-43-6647-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
QGP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.963797
SNU-C1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
methacholine chloride-3452	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Metabolism of steroids	Reactome Pathways 2024	1.0	null
IRS4	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8002-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4498179-srep11671-s1.pdf-246-SOX7_SOX7	Rummagene Transcription Factor Associations 2026	1.0	null
CL-11	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Uterine cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.248
GTEX-RU72-1026-SM-46MUG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00916
NCIH727	DepMap CRISPR Gene Dependency	1.0	2.64697
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37524
PPP2CA	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K40175214_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
vegf	Phosphosite Textmining Biological Term Annotations	1.0	null
SERPINH1	Pathway Commons Protein-Protein Interactions	1.0	null
CCT4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840085
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970541
BRD-K96209756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25253
GSE154350_1_v_0_ascl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ARMCX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54245
layer 1 of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12288
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.98068
GSE120612_7_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Luminespib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126111
HPAC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.851223
positive regulation of biological process	GO Biological Process Annotations 2015	1.0	null
SOX2-21211035-LN229-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K50423606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32684
GSE139239_2_v_6_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XUJ4-1726-SM-4BONW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04467
karpas707	HPA Cell Line Gene Expression Profiles	-1.0	-2.39694
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GU-06A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7745-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K75451592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1752
KRT5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K26091803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.6967
establishment of localization	GO Biological Process Annotations 2015	1.0	null
GSE182680,GSE182683_10_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNUC2A	CCLE Cell Line Gene Mutation Profiles	1.0	null
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
tobacco use disorder	GAD Gene-Disease Associations	1.0	null
GSE144347_1_v_0_crnkl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE241036_4_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
496100496_FWM_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.60444
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.884847
GSE181003_3_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226544_1_v_0_hnrnpa2b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
COLO-668	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Stat5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.5733
uterus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
LBX2	Pathway Commons Protein-Protein Interactions	1.0	null
Portal vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.227
nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.27153
adipocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.608527
DNAJB12	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YWHAG	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20N-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DSP	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XUJ4-2626-SM-4BOQ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4402
H2595	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H250	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GAMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.42596
CRCGN017_MCF10A.WT.HP_24H:P15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19325
caudal presubiculum (postsubiculum)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.904264
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29C-06A-21R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.677673
Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain	InterPro Predicted Protein Domain Annotations	1.0	null
MATR3	Pathway Commons Protein-Protein Interactions	1.0	null
male	Phosphosite Textmining Biological Term Annotations	1.0	null
alpha1	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75097
monocarboxylic acid biosynthetic process	GO Biological Process Annotations 2025	1.0	null
FERMT3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A45333398_PERIPLOCYMARIN_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PRR11	Pathway Commons Protein-Protein Interactions	1.0	null
mitochondrial transport	GO Biological Process Annotations 2015	1.0	null
NCI-H2369	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.927323
obesity	GWASdb SNP-Phenotype Associations	1.0	0.647367
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.50471
fluoxetine-3314	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Defective CD320 causes methylmalonic aciduria	Reactome Pathways 2014	1.0	null
CEP170	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF263-19887448-K562-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
negative regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
abnormal muscle physiology	MPO Gene-Phenotype Associations	1.0	null
GSE152441,GSE152442_7_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_CEP-33779_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121954
BRD-K43387144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58364
GSE157960_2_v_3_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Female reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.248
BRD-K02822062_CT-200783_U937_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
spinal (inferior) vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.79037
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16067
BRD-K02283807_GR 32191 hydrochloride_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
sulfonamides	Phosphosite Textmining Biological Term Annotations	1.0	null
GSE96991,GSE97117_3_v_1_il11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
trimethylcolchicinic acid-2146	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DU4475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.856843
BRD-A39093044_K784-3187_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE210885_0_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal blood homeostasis	MPO Gene-Phenotype Associations	1.0	null
Necrotizing Enterocolitis In Fetus Or Newborn	DisGeNET Gene-Disease Associations	1.0	null
BRD-K73982490_B3063_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-3613-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
GSE225901_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
STRADB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00635778
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4112
SUCLG2	Pathway Commons Protein-Protein Interactions	1.0	null
lateral part of CoP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08339
anterior pretectal nucleus, dorsal superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.03299
Mammary gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.613
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.204
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Hyperbilirubinemia	CTD Gene-Disease Associations	1.0	1.03715
crystal	GeneRIF Biological Term Annotations	1.0	null
GTEX-WH7G-1126-SM-3NMBK	GTEx Tissue Sample Gene Expression Profiles	1.0	2.16859
stability	GeneRIF Biological Term Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8201-11A-01R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-7107-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NRDE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29573
ISTMES1	CCLE Cell Line Gene Mutation Profiles	1.0	null
LN-18	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K89524688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43049
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.64011
GTEX-WCDI-0008-SM-47JYE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17721
methylprednisolone-1567	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22275
Perturb_4180_KO_Tsc1_SRP279018	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.96683
inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.947542
Obesity	HuGE Navigator Gene-Phenotype Associations	1.0	null
caudal subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.866644
Thigh	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.511
GSE137144_2_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4553
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50195
hsa-miR-4732-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.088999
GSE179002_4_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SUCS-1626-SM-32PLS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865555
mitochondrial outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Intrinsic component of peroxisomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.766
sensitivity	GeneRIF Biological Term Annotations	1.0	null
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3813
BRD-K77877933_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
JHUEM1	DepMap CRISPR Gene Dependency	1.0	3.04986
HEC108	CCLE Cell Line Gene Mutation Profiles	1.0	null
Adenocarcinoma	CTD Gene-Disease Associations	1.0	1.23296
K562_Hesperadin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163654
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
hsa-miR-548f	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7487
reticular formation of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0344
JVM-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RAD50	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K94012289_OSI-027_PC3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CNOT1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QLQ7-0008-SM-447AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.878944
STAT6	MotifMap Predicted Transcription Factor Targets	1.0	null
Mesenteric adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.111
FASTKD1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE48812_7_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.444
transcriptional	GeneRIF Biological Term Annotations	1.0	null
breast	GTEx Tissue Gene Expression Profiles	1.0	1.02851
GSE188870,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110268_2_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Insulin Resistance	CTD Gene-Disease Associations	1.0	2.88009
CDR2L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00603424
A549_Droxinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145531
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73F-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K32896438_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
superficial stratum of PcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54985
HNRNPA2B1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K98061543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95687
ligase activity, forming carbon-nitrogen bonds	GO Molecular Function Annotations 2015	1.0	null
prochlorperazine-1156	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Tandutinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.4
PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
JVM3	CCLE Cell Line Gene CNV Profiles	1.0	1.58424
SYK_knockdown_191_GSE54065	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.4226
Perturb_11136_KO_Scap_SRP082562	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.41102
GSE208350_4_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE207135_2_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-O5YT-0008-SM-4E3IQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25049
r6 part of spinal vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32465
GSE202434,GSE202438_10_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147662_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.66
posteroventral (inferior) parietal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09345
RPL14	Pathway Commons Protein-Protein Interactions	1.0	null
DENND3	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7055-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.906155
OVMANA	CCLE Cell Line Gene Mutation Profiles	1.0	null
negative regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE158182_4_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XV7Q-1726-SM-4BRUU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21376
NCIH2106	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33278
PRDX1	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4415-01A-22R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Vomiting	CTD Gene-Disease Associations	1.0	1.56558
BRD-A85860691_chaetocin_NCIH1694_6.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE158182_5_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CNKSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32673
Malignant astrocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.147
A549_Momelotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123432
GSE248935_1_v_0_cd14_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903496
BRD-K18787491_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
phosphate-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
Right_Atrium	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.16791
Prostate adenocarcinoma_PRAD_TCGA-EJ-7123-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1143	GDSC Cell Line Gene Expression Profiles	-1.0	-1.98448
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09799
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.973025
acyl-coa metabolic process	GO Biological Process Annotations 2015	1.0	null
APC	Pathway Commons Protein-Protein Interactions	1.0	null
Glycogen metabolism disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.213
cellular component assembly	GO Biological Process Annotations 2015	1.0	null
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KCNG3	Pathway Commons Protein-Protein Interactions	1.0	null
abnormal body weight	MPO Gene-Phenotype Associations	1.0	null
betaacc2	GeneRIF Biological Term Annotations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6985-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K74712962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04519
A549_Nintedanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0260927
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.06084
RDES	CCLE Cell Line Gene Expression Profiles	1.0	1.79498
rosiglitazone-6192	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K10882151_BO2 (inhibits RAD51)_A375_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
growth/size/body phenotype	MPO Gene-Phenotype Associations	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.57072
BRD-K49669041_BX-912_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A77577770_AC-1121_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC16A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00571101
Movement Disorders	CTD Gene-Disease Associations	1.0	1.57782
BRD-K42308740_ST056792_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Muscle Weakness	CTD Gene-Disease Associations	1.0	1.4351
KRT81	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.990845
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91562
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839759
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169155_3_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
mRNA_POU5F1_16767105	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE158834_0_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF667	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61126
hsa-miR-548d-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
BRD-K76067434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0721
15897907-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
outer SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29452
GSE132408_0_v_3_tet2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE159084_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SMRT-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ETV5::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.4644
CFPAC-1	GDSC Cell Line Gene Expression Profiles	-1.0	-2.22141
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.526
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17336
GTEX-OXRP-0226-SM-3NB14	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69795
BRD-K77392050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1952
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.37555
BRD-K47832606_Floxuridine_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.17082
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88498
RECQL4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE118794_0_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06384
H3K27me3_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Extensor digitorum longus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.459
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4796-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
CBP-21632823-H3396-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
protein tetramerization	GO Biological Process Annotations 2023	1.0	null
GSE164874_5_v_4_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Plastid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.795
GSE172146_2_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE89767_2_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131649_6_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S4Z8-1826-SM-3K2BH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29138
NCIH3255	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54262
GSE102870_3_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
macromolecular complex assembly	GO Biological Process Annotations 2015	1.0	null
nucleus	GO Cellular Component Annotations 2015	1.0	null
PMC2883591-pgen.1000979.s003.xls-NRSF_GENELISTS_WitOut_GeneSig_g-Supplemental_Table_3_REST	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6828764-41419_2019_2062_MOESM2_ESM.xlsx-GATA3_UTX_promoter_gene-ENSEMBL_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6659998__F3	PFOCR Pathway Figure Associations 2023	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8429-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K84593579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03273
GSE148200_1_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UBA52	Pathway Commons Protein-Protein Interactions	1.0	null
SKIV2L2	Pathway Commons Protein-Protein Interactions	1.0	null
promyelocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.355942
LRP1B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OXRK-0008-SM-3NB28	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.98269
Perturb_10834_KO_Xbp1_SRP197108	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.37117
HCC1419	CCLE Cell Line Gene Mutation Profiles	1.0	null
SIHA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K83336168_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE125007,GSE125008_5_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNU1077	CCLE Cell Line Gene CNV Profiles	-1.0	-2.02249
Lung squamous cell carcinoma_LUSC_TCGA-92-7340-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RL952	CCLE Cell Line Gene Mutation Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EC-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EVSAT	DepMap CRISPR Gene Dependency	1.0	2.42281
GSE217873_1_v_0_nusap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8563805-41598_2021_858_MOESM2_ESM.xlsx-Supplementary_Info_6-Gene_List_6_The_list_of_human_orthologs_of_the_downregulated_fly_DEGs_identified_from_TRAP_control_vs_PARIS_wild_type_comparison_ZNF746	Rummagene Transcription Factor Associations 2026	1.0	null
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.320677
PMC4467436-oncotarget-06-6267-s002.xlsx-140527_cd44Cutoff_txt-PAX6-M_PAX6	Rummagene Transcription Factor Associations 2026	1.0	null
HNRNPH1	Pathway Commons Protein-Protein Interactions	1.0	null
beta1	Phosphosite Textmining Biological Term Annotations	1.0	null
Papilloma	CTD Gene-Disease Associations	1.0	1.02858
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.2438
GTEX-QEL4-0326-SM-3GAE5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.980916
GSE199921_1_v_0_romidepsin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.462
CORL51	CCLE Cell Line Gene CNV Profiles	-1.0	-1.82614
PSMD2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE62843,GSE64370_0_v_1_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K08899466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33171
PMC8755441-mmc3.xlsx-IRF1-UP-Symbol_1_IRF1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QMR6-0008-SM-447AV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47869
BRD-K23644387_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR3A	Pathway Commons Protein-Protein Interactions	1.0	null
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33971
SHKBP1	Pathway Commons Protein-Protein Interactions	1.0	null
Copula pyramidis, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36421
HCC1419	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CSF1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-NL4W-0008-SM-4E3I2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49974
infection	Phosphosite Textmining Biological Term Annotations	1.0	null
EP400	Pathway Commons Protein-Protein Interactions	1.0	null
Human - Adipose - L2 - hAd3	HuBMAP Azimuth Cell Type Annotations	1.0	null
PMC5617203-pone.0185396.s001.xls-exclude_SNPs_without_known_MAF-Gene_symbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
PIM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00541873
TRIM24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14412
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32726
PMC10959942-41525_2024_411_MOESM1_ESM.pdf-50-MYF6_MYF6	Rummagene Transcription Factor Associations 2026	1.0	null
Semitendinosus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.823
A549_FLLL32_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142457
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.920158
GSE134191_3_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S4UY-0526-SM-3K2AN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37565
PMC7495487-41598_2020_71030_MOESM2_ESM.xlsx-Sheet1-NR1A1_THRA	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K67137502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35927
GSE189653,GSE203344_2_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PRKAG2	Pathway Commons Protein-Protein Interactions	1.0	null
KCL22	CCLE Cell Line Gene Expression Profiles	-1.0	-2.12442
RBBP5	ENCODE Transcription Factor Targets	1.0	null
CRCGN008_HEPG2_24H:G24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.49136
Pancreatic alpha cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.769
MSX1_01_281	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.45627
BRD-K89687904_PKCbeta inhibitor_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41434
BRD-K07501326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76831
nephron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063544
BRD-K63209730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47205
periventricular stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.89539
BRD-K15025317_Bay 11-7821_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Mesothelioma_MESO_TCGA-MQ-A6BS-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
organelle outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K82126187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23362
Acute Myeloid Leukemia_LAML_TCGA-AB-3007-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE139975_3_v_0_rnf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_FLLL32_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167086
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.11092
BRD-K37206356_RHAMNETIN_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC8834222__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-A4P8-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abdominal adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.50079
chinese	GeneRIF Biological Term Annotations	1.0	null
tonsil	HPA Tissue Gene Expression Profiles	-1.0	-0.90126
protein homooligomerization	GO Biological Process Annotations 2023	1.0	null
CCT3	Pathway Commons Protein-Protein Interactions	1.0	null
CKAP4	Pathway Commons Protein-Protein Interactions	1.0	null
Malonyl-CoA	HMDB Metabolites of Enzymes	1.0	null
superficial layers of TG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53929
elevation	GeneRIF Biological Term Annotations	1.0	null
COV644	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.87987
Lung Diseases	CTD Gene-Disease Associations	1.0	1.62512
Reticular nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18031
Scent gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.905
Perturb_10841_KO_Xbp1_SRP197108	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.761
zfpm2_19411579_heart_lof_mouse_gpl1261_gds3659	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.690004
GTEX-R55E-0008-SM-48FCG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866028
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE201217_4_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
plant embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.247719
TFAP2C_01_312	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.64238
BRD-K10882151_BO2 (inhibits RAD51)_SKM1_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
purine nucleoside binding	GO Molecular Function Annotations 2015	1.0	null
PHB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83187
GTEX-XUW1-0008-SM-4BOQH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923529
GSE158853_0_v_1_hmgcs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE105406_0_v_3_ptcd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.777
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3WC-11A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE217526_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.55018
fatty	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50539
Gastrocnemius	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.55
GSE147662_2_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26515
purine ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
alphahelices	GeneRIF Biological Term Annotations	1.0	null
A549_MC1568_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0258577
GSE241402_0_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A34907681_rutin_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
protein homooligomerization	GO Biological Process Annotations 2015	1.0	null
BRD-A72711497_LASALOCID SODIUM_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SKA2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE135030_8_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
decreased fatty acid level	MPO Gene-Phenotype Associations	1.0	null
GSE95077_1_v_0_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
HMV-II	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PLEKHH1	Pathway Commons Protein-Protein Interactions	1.0	null
viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE225218_2_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IGROV1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-2.71566
BRD-K44366801_NCGC00182371-01_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
cytoplasmic part	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K85919350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48332
ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
Vertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.398
posterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.54473
JHU-011	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SK-N-FI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3785
Duodenum Mucosa	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.02512
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-3.17313
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32053
GSE114992,GSE114993_7_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.66118
TBX3-20139965-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
mantle zone of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25162
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CHLA15	DepMap CRISPR Gene Dependency	1.0	2.00461
H3K27me3_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21	Pathway Commons Protein-Protein Interactions	1.0	null
Uterine Cervical Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K49865102_PD-0325901_HEPG2_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EW-18	GDSC Cell Line Gene Expression Profiles	1.0	1.81981
BRD-A99164655_Dihydrexidine hydrochloride_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC9195629-Table1.xlsx-Supplementary_Table_1-JUN_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XGQ4-1026-SM-4AT4L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50684
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K60692685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89892
h9c2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.874439
BRD-K07303502_Arachidonyl trifluoro-methyl ketone_MDST8_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K70537701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24498
BRD-K86155080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12595
fatty acid transport	GO Biological Process Annotations 2015	1.0	null
Parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09264
GTEX-UTHO-1826-SM-3GAFE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10717
CDC42	Pathway Commons Protein-Protein Interactions	1.0	null
SNU-175	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.9265
SK-MG-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
mammalian	GeneRIF Biological Term Annotations	1.0	null
GTEX-QV44-1825-SM-447CF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.926377
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.872461
Mental Disorders	CTD Gene-Disease Associations	1.0	1.15729
Breast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
RPL23	Pathway Commons Protein-Protein Interactions	1.0	null
embryonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061557
such	GeneRIF Biological Term Annotations	1.0	null
meclofenamic acid-2128	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NUGC4	CCLE Cell Line Gene Mutation Profiles	1.0	null
RBM25	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-90-6837-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Fasudil_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144328
BRD-K22503835_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.26
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
Obesity_Muscle - Striated (Skeletal) (MMHCC)_GSE474	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.77257
CoA carboxylase activity	GO Molecular Function Annotations 2023	1.0	null
Hs-578-T	GDSC Cell Line Gene Expression Profiles	-1.0	-1.72936
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PRMT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00510406
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
chloramphenicol-1795	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
fruit	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.129484
Inferior vena cava	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.945
GSE70499_0_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SCC-25	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.36869
Intrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.24
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.33405
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.845116
GSE195559_2_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.350084
RPS14	Pathway Commons Protein-Protein Interactions	1.0	null
GSE102486,GSE102490_1_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RBM7	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U8XE-1726-SM-4E3IF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.938452
BRD-K65828139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.621
GSE245270_1_v_4_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
biological regulation	GO Biological Process Annotations 2015	1.0	null
BRD-K24132293_piperlongumine (HPLC)_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4334-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE159937_2_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K77713205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43067
CRCGN015_HEPG2_48H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04946
PMC3761196__F7	PFOCR Pathway Figure Associations 2024	1.0	null
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.228
MYL6	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K41655405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00467
polyphagia	MGI Mouse Phenotype Associations 2023	1.0	null
Perturb_1428_KO_Adm2_SRP399375	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.05644
GSE178714_5_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Squamous Cell Carcinoma Of The Head And Neck	DisGeNET Gene-Disease Associations	1.0	null
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.674
NNT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24993
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04327
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Single hybrid motif	InterPro Predicted Protein Domain Annotations	1.0	null
depression	Phosphosite Textmining Biological Term Annotations	1.0	null
tissue	GeneRIF Biological Term Annotations	1.0	null
lymphoid progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.523588
ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
Perturb_13648_OE_miR24_SRP067253	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.28583
Medial geniculate complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3534
spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073439
GSE152441,GSE152442_1_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_11073_Mut_Tak1/Ripk1_SRP256942	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.26564
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.964449
cellular nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.323
posteromedial visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.16597
hsa-miR-626	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GTEX-XUW1-0526-SM-4BOP3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47567
BRD-K02822062_CT-200783_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
dorsal thalamus_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.12908
OVCAR5	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.07217
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.100868
BRD-A63998256_Helveticoside_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
increased food intake	MPO Gene-Phenotype Associations	1.0	null
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.428
NGP	DepMap CRISPR Gene Dependency	1.0	18.0926
TEX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72645
BRD-K10343715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02653
nialamide-3871	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K34092021_Arvanil_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.074594
VDR-24763502-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-RUSQ-2026-SM-4GIAK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17579
Defects in vitamin and cofactor metabolism	Reactome Pathways 2014	1.0	null
BRD-K28079391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21418
PMC12478325-12672_2025_3468_MOESM1_ESM.xlsx-Table_S9-Table_S9_Results_of_MR_analysis_between_druggable_genes_eQTLs_and_CrNEN_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.047002
TRO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4896
P68-20966046-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE138672_0_v_1_rabgef1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.42164
Fat-mesenchymal stem cell	Tabula Sapiens Gene-Cell Associations	1.0	4.5799
Digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.535
PMC5550886-cddis2017345x3.xlsx-siRAD21_DEGs_NOT_rescued_by_Myc-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A5RJ-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
carbohydrate metabolism disease	GWASdb SNP-Disease Associations	1.0	0.290389
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.55
BRD-K88988134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10868
GTEX-OHPK-0226-SM-3MJH6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44911
hematopoietic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07212
GTEX-R53T-1626-SM-3GAEW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965352
BRD-K38477985_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ESR1-30970003-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
PMC7773934-Table_1.XLSX-Table_S2-Supplementary_Table_2_TBX22_co-expressed_genes_detailed_results_TBX22	Rummagene Transcription Factor Associations 2026	1.0	null
leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055342
glioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.099184
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17011
BRD-K25517783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16837
Propanoate metabolism	KEGG Pathways 2026	1.0	null
HEC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-QV31-1326-SM-2S1QE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43425
GSE135514_8_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.51095
GTEX-Q2AH-0008-SM-48U2J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.895085
MCF7_Tanespimycin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152985
GSE131649_6_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K82135108_elesclomol_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09228
leg muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.1585
Perturb_2418_OE_PDE5_ERP011301	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
496100551_PCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.28163
Bed nuclei of the stria terminalis, anterior division, magnocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48311
MCM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3264
response to drug	GO Biological Process Annotations 2015	1.0	null
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
orbital frontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.934808
carnitine transmembrane transport	GO Biological Process Annotations 2015	1.0	null
monocarboxylic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
r7 part of cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.11711
PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1d-List_of_2302_of_genes_differentially_regulated_by_SOX2_FDR_0_1_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.580017
Vasculitis	CTD Gene-Disease Associations	1.0	1.02336
GSE163809_1_v_2_sdhaf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.05946
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057496
Perturb_2369_KD_PRPF8_ERP008458	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
JHH7_LIVER	CCLE Cell Line Proteomics	1.0	2.8785
PRKAB1	Hub Proteins Protein-Protein Interactions	1.0	null
BRD-K74710236_VU0410183-2_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.839
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
vidarabine-2706	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WFON-2226-SM-3TW8W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.867664
Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FO-11A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CYBA	Pathway Commons Protein-Protein Interactions	1.0	null
GSE131798,GSE131804_2_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
increased triglyceride level	MPO Gene-Phenotype Associations	1.0	null
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Plasma lipoprotein particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.171
IGR39	Achilles Cell Line Gene Essentiality Profiles	1.0	1.14652
outer SZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.918377
GTEX-QMRM-1726-SM-2S1QG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25232
nucleobase-containing small molecule metabolic process	GO Biological Process Annotations 2015	1.0	null
Amino acid metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.497
YBX1	Pathway Commons Protein-Protein Interactions	1.0	null
NSG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66705
affect	GeneRIF Biological Term Annotations	1.0	null
abnormal postnatal growth/weight/body size	MPO Gene-Phenotype Associations	1.0	null
BRD-K73695595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18044
BRD-K92372829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.448
solitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.5274
p1 portion of the paranigral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27085
abnormal glycogen homeostasis	MPO Gene-Phenotype Associations	1.0	null
GSE70499_4_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TC71	CCLE Cell Line Gene CNV Profiles	-1.0	-1.5283
KM-12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.17445
fat pad	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.656648
Metabolism of water-soluble vitamins and cofactors	Reactome Pathways 2014	1.0	null
BRD-K40485332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35289
Creatine kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.805
SW156	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-A22502289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.64963
BRD-A79768653_sirolimus_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Glycogen storage disease V	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.444
Neurologic Manifestations	CTD Gene-Disease Associations	1.0	1.26794
A549_XAV-939_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170425
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.928309
reticular nucleus of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.853255
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
enzyme	GeneRIF Biological Term Annotations	1.0	null
GSE196699_7_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_0Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-0.828455
liver	HPA Tissue Gene Expression Profiles	1.0	0.884681
KRT6B	Pathway Commons Protein-Protein Interactions	1.0	null
plasma	Phosphosite Textmining Biological Term Annotations	1.0	null
Proteinuria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.157
GSE93124_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158632_2_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Fatty Liver, Alcoholic	CTD Gene-Disease Associations	1.0	1.02671
GSE171292_5_v_2_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Renal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
H3K27me3_CH12.LX_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amide binding	GO Molecular Function Annotations 2015	1.0	null
Adenoid Cystic Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
meticrane-1792	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nordihydroguaiaretic acid-1164	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC4841025__F7	PFOCR Pathway Figure Associations 2024	1.0	null
PMC4732299__F5	PFOCR Pathway Figure Associations 2024	1.0	null
Pancreatic beta cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.666
BRD-K47988839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78083
BT-483	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
GSE152937_6_v_5_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mantle zone of IC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09801
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.88229
BRD-K98548675_Parthenolide_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC12290113-41598_2025_12350_MOESM1_ESM.pdf-4-GATA6-AS1_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
superior frontal gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.65824
positive	GeneRIF Biological Term Annotations	1.0	null
PA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
organelle	GO Cellular Component Annotations 2015	1.0	null
mapkdependent	GeneRIF Biological Term Annotations	1.0	null
Fatty Liver	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K52989901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37713
CK1G3	Kinase Library Serine Threonine Kinome Atlas	1.0	null
MYO1D	Pathway Commons Protein-Protein Interactions	1.0	null
dexamethasone_mus musculus_gpl6105_gse44208	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
smooth muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.68434
GSE161827_0_v_3_ertugliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.884
MEIS1-26253404-OPTIC-CUPS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20936
Biotin deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.005
TOFA	DGIdb Drug Targets 2026	1.0	2.2055
periventricular stratum of r2BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46312
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21288
Diabetic retinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-260_ChIP-Seq_H3K9me1_2_AR_differential_down_regulation_upon_KDM3A_or_AR_knockdown_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8582123-13073_2021_996_MOESM4_ESM.xlsx-SATB1-HIT_SATB1	Rummagene Transcription Factor Associations 2026	1.0	null
endocrine pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.169071
EMX2_Deficiency_GDS3173_607_mouse_Embryonic urogenital epithelium - day 10.5	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
K562_CUDC-907_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180115
Hyperlipidemias	HuGE Navigator Gene-Phenotype Associations	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.861069
Lipid storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.392
PFEIFFER	CCLE Cell Line Gene Expression Profiles	1.0	2.137
A549_Ivosidenib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155515
FU97	CCLE Cell Line Gene Mutation Profiles	1.0	null
EW-16	GDSC Cell Line Gene Expression Profiles	1.0	2.43566
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.403
Pancreatic Neoplasms	CTD Gene-Disease Associations	1.0	1.48916
DEOC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.835414
TCF21-26020271-SMOOTH-MUSCLE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-485-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Lipid metabolism disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.129
HSF1-23293686-STHDH-STRIATAL-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
exercise	GeneRIF Biological Term Annotations	1.0	null
GTEX-R55C-1626-SM-48FEG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28915
PGD	Pathway Commons Protein-Protein Interactions	1.0	null
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.985549
gata4_21746915_heart_lof_mouse_gpl6246_gds3931	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.958911
NUGC-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.943859
BRD-K99125195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07373
IL16	Pathway Commons Protein-Protein Interactions	1.0	null
MFHAS1	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Dasatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0280488
chr12_109267806_A_G_b38	GTEx eQTL 2025	1.0	2.68817
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.944261
PMC12549544-mmc2.xlsx-AA_D7_VS_D14-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873627
GSE216273,GSE216292_0_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hnf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.4259
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-8497-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
alimemazine-3478	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC9287735-mmc7.xlsx-PharmMapper-NR1D2_NR1D2	Rummagene Transcription Factor Associations 2026	1.0	null
HNF4 direct repeat 1	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K87404495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32598
BRD-K85802892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26003
GTEX-POYW-0526-SM-2XCEY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925093
BRD-K29395450_PIK-93_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S341-1626-SM-3K2B8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63
Right_Ventricle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.969438
GTEX-XUJ4-2526-SM-4BOO4	GTEx Tissue Sample Gene Expression Profiles	1.0	2.50768
plant reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.116373
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3328-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH196	Achilles Cell Line Gene Essentiality Profiles	1.0	1.42186
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.265
GTEX-PVOW-0008-SM-48TE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34257
GSE214212_3_v_1_chd6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of SeDg	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06418
GSE210662_3_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	-1.0	null
uptake	Phosphosite Textmining Biological Term Annotations	1.0	null
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.311
Kidney Diseases	CTD Gene-Disease Associations	1.0	2.45886
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3374-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organic acidemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.350084
BRD-K47366416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04507
BRD-A95820578_NP-006304_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HIST1H2AB	Pathway Commons Protein-Protein Interactions	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hexylcaine-5768	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
dorsomedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.840345
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.248
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8218
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941782
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28315
liver	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K41814083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32222
BRD-K47794327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96181
GSE221327_8_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Muscular Diseases	CTD Gene-Disease Associations	1.0	1.90476
BRD-A20697603_598226_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostatic Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K08463963_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mitochondrial outer membrane	GO Cellular Component Annotations 2015	1.0	null
19192944-TableS4	GeneSigDB Published Gene Signatures	1.0	null
TTC642	DepMap CRISPR Gene Dependency	1.0	2.81521
BRD-K64509231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09932
OVK-18	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ERF::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7631
observations	GeneRIF Biological Term Annotations	1.0	null
BRD-K84334677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16216
heart	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.695354
A549_CUDC-101_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182598
Anterolateral visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04551
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.986099
FBXO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02874
plasma	GeneRIF Biological Term Annotations	1.0	null
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.74335
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.858
NUFIP2	Pathway Commons Protein-Protein Interactions	1.0	null
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14847
RPL30	Pathway Commons Protein-Protein Interactions	1.0	null
59M	CCLE Cell Line Gene Expression Profiles	-1.0	-1.5286
GTEX-RM2N-1726-SM-2TF55	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20442
Lung adenocarcinoma_LUAD_TCGA-44-6778-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CREB1-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CYP2U1	Pathway Commons Protein-Protein Interactions	1.0	null
TTNPB-223	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PFKM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00381836
lidocaine-1499	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
purine nucleoside bisphosphate biosynthetic process	GO Biological Process Annotations 2015	1.0	null
primary auditory cortex (core)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18907
ISL1-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WFG8-2326-SM-3GILF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92533
GSE239844_8_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE183251_7_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Metabolism of vitamins and cofactors	Reactome Pathways 2014	1.0	null
Glycogen storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.214
opposite	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-1250	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
KIAA0319	Pathway Commons Protein-Protein Interactions	1.0	null
peroxisome	Phosphosite Textmining Biological Term Annotations	1.0	null
NR3C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.7503
EW-12	COSMIC Cell Line Gene Mutation Profiles	1.0	null
accbeta	GeneRIF Biological Term Annotations	1.0	null
abnormal oxygen consumption	MPO Gene-Phenotype Associations	1.0	null
GTEX-SNOS-1426-SM-32PLY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01517
MIB1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE226114,GSE226116_2_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RPLP0	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RP-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WIPF1	Pathway Commons Protein-Protein Interactions	1.0	null
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
BRD-K29415052_NVP-BGT226_HCC515_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JHH-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
salivary gland adenoid cystic carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.352291
BRD-K26306512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.30007
Lung adenocarcinoma_LUAD_TCGA-NJ-A55O-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE152441,GSE152442_1_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MKN45	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47486
TUR	GDSC Cell Line Gene Expression Profiles	1.0	1.8134
GSE174498,GSE174500_2_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
EBNA1-20929547-CHIP-SEQ-RAJI-CELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
DHX58	Pathway Commons Protein-Protein Interactions	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC7284929__F7	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K89687904_PKCbeta inhibitor_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Ro 48-8071	DeepCoverMOA Drug Mechanisms of Action	1.0	0.56
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAUZ-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S32W-2226-SM-2XCAY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45739
BRD-K24132293_PIPLARTINE_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC12179525-mmc1.xlsx-Group_HNF4A_vs_Null_sign-Supplemental_Table_S1_Differentially_expressed_genes_in_HNF4A-transduced_cells_vs_Null_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
coa carboxylase activity	GO Molecular Function Annotations 2015	1.0	null
acetyl-CoA carboxylase activity	GO Molecular Function Annotations 2025	1.0	null
Hepatoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.789
PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_EVT-Gene_Symbol_GCM1	Rummagene Transcription Factor Associations 2026	1.0	null
cytosol	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.471208
Phospholamban complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.175
posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.845014
NAMALWA	CCLE Cell Line Gene Mutation Profiles	1.0	null
NCI-H630	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_PJ34_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202676
BACH1-22875853-CHIP-PCR-HELA-AND-SCP4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.248
Brain Lower Grade Glioma_LGG_TCGA-HT-7469-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ligandbinding	GeneRIF Biological Term Annotations	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-F2-6880-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EBC1	CCLE Cell Line Gene Mutation Profiles	1.0	null
cation transport	GO Biological Process Annotations 2015	1.0	null
GTEX-XPT6-2026-SM-4B64V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43378
BRD-K13110820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14358
BRD-K83213911_PF 750_H1299_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Sleep disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.016
superior temporal gyrus, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.850728
KMS-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.69873
CBFB	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7146
BRD-K67661742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05547
MOLM6	CCLE Cell Line Gene Expression Profiles	-1.0	-1.51264
golgi apparatus	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE92364_1_v_3_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cytosolic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.066985
small intestine	HPA Tissue Protein Expression Profiles	1.0	1.16855
Ammonium transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.674
BRD-A35588707_TENIPOSIDE_JHUEM2_6.0_h_1.25_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC6995218-12864_2020_6525_MOESM6_ESM.xlsx-Conc_Lipid_97_AR-DE-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
RUNX1	Pathway Commons Protein-Protein Interactions	1.0	null
quinisocaine-2151	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CEP55	Pathway Commons Protein-Protein Interactions	1.0	null
SDCCAG3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K40901640_CINANSERIN_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.920328
nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
ACTC1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QV44-2026-SM-2S1RD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850166
GSE180200,GSE180201_3_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131649_6_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TPP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K88282877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07288
Hmgn1_KO_GDS5010_405_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE120413,GSE120447_0_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.52556
18537972-TableS4	GeneSigDB Published Gene Signatures	1.0	null
Postsubiculum, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4045
ZNF703	Pathway Commons Protein-Protein Interactions	1.0	null
PMC13082837-NIHMS2159075-supplement-3.xlsx-DataTable5_Methylation_LMS-UCSC_RefGene_Name_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
triglyceride-rich lipoprotein particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.21716
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PPP2R2B	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-371b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
mitochondrial	Phosphosite Textmining Biological Term Annotations	1.0	null
TCF7-22412390-EML-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC12069319-Table1.xlsx-OCAB_p35_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE228181_3_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
S100A8	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8564-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-3923-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Obesity	DisGeNET Gene-Disease Associations	1.0	null
Coronary Artery Disease	DisGeNET Gene-Disease Associations	1.0	null
posteroventral (inferior) parietal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.14618
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3433-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cardiac	Phosphosite Textmining Biological Term Annotations	1.0	null
BRD-K16715205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0532
red nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.855316
PLEKHJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03258
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
ANXA2	Pathway Commons Protein-Protein Interactions	1.0	null
Cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.183
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE245270_1_v_5_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Neurogenic Inflammation	CTD Gene-Disease Associations	1.0	1.08975
PHF6	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K86143816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60442
BRD-K56884305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65626
negative regulation of lipid metabolic process	GO Biological Process Annotations 2015	1.0	null
risperidone-2947	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE135030_8_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormal total tissue mass	MPO Gene-Phenotype Associations	1.0	null
purine nucleotide biosynthetic process	GO Biological Process Annotations 2015	1.0	null
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14584
lateral tuberal nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22742
stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076136
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE217694_4_v_0_pold1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrial ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.12
BRD-K34590335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37006
BRD-K97943226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2945
CP-690334-01-4383	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE166536_3_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.17422
mitochondrial envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
PADI2	Pathway Commons Protein-Protein Interactions	1.0	null
Manganese	HMDB Metabolites of Enzymes	1.0	null
PMC12068594-pgen.1011693.s007.xlsx-MCR_vs_MCW-gene_id_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
SLC26A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00448153
Carcinoma, Squamous Cell	CTD Gene-Disease Associations	1.0	1.12254
Nerve - Tibial	GTEx Tissue Gene Expression Profiles 2023	1.0	1.01447
A549_Tozasertib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.012403
BRD-K27109474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83077
PCCA	Pathway Commons Protein-Protein Interactions	1.0	null
GSE152441,GSE152442_0_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K24640918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08436
GTEX-P4PQ-0226-SM-2S1NK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983358
BRD-K34414758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25197
GTEX-RM2N-0008-SM-48FF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61259
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.736014
decreased total body fat amount	MGI Mouse Phenotype Associations 2023	1.0	null
ACTB	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A35989968_MEGESTROL ACETATE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TNPO1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K08458391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06979
GTEX-S4UY-0726-SM-4AD6X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.998671
Rumen	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.833
PMC3861642__F9	PFOCR Pathway Figure Associations 2024	1.0	null
Medial amygdalar nucleus, posterodorsal part, sublayer b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10242
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2351
Pancreatic islet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.712
hsa-miR-298	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
population	GeneRIF Biological Term Annotations	1.0	null
GSE225684_0_v_2_tfap4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FTC133	CCLE Cell Line Gene Mutation Profiles	1.0	null
mantle zone of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.11711
BRD-A20697603_T8902_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OHPM-0008-SM-4E3IP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.931525
Mitochondrial respirasome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.598
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Differentially_expressed_genes_identified_in_bulk_RNA-seq_of_FOXO1-_-_vs_FOXO1_hMSCs_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_14966_OE_miR424_SRP341198	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE174498,GSE174500_2_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.983083
Edema	CTD Gene-Disease Associations	1.0	2.0154
Fatty acid beta-oxidation multienzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.602
GSE126402_4_v_0_tal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Medial geniculate complex, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12079
GTEX-OOBK-0008-SM-3NB27	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53829
NCI-H1650	GDSC Cell Line Gene Expression Profiles	-1.0	-1.76298
BRD-K17743125_S1085_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Exanthema	CTD Gene-Disease Associations	1.0	1.34343
positive regulation of heart growth	GO Biological Process Annotations 2015	1.0	null
cAMP-dependent protein kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.865
TBX20-22328084-HEART-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5580-11A-02R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K71109636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35572
3t3-l1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.318042
Zfp809	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.9195
acc1	GeneRIF Biological Term Annotations	1.0	null
WDFY3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE182680,GSE182683_5_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
UACC257	CCLE Cell Line Gene CNV Profiles	1.0	2.14323
Acetyl-CoA	HMDB Metabolites of Enzymes	1.0	null
Perturb_6568_KO_Ywhaz_SRP056013	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.45691
abnormal body composition	MPO Gene-Phenotype Associations	1.0	null
hsa-miR-4421	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCallEPC1-PHF1_H3K27me3_k562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S4Q7-1526-SM-3K2AG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39345
PMC10702478-jci-133-161348-s262.xlsx-High_targets8listes_TPM_DE-List_of_high_confidence_targets_of_PPAR_genes_regulated_after_18h_in_Mo_by_PA_PPARA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169152_3_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DYNC1LI1	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular lipid transport	GO Biological Process Annotations 2015	1.0	null
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.327
Biotin/lipoyl attachment	InterPro Predicted Protein Domain Annotations	1.0	null
organic acid transport	GO Biological Process Annotations 2015	1.0	null
H3K36me3_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
sulfamethoxazole-2296	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
renal proximal tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.240826
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.53567
nucleoside biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GTEX-XAJ8-0226-SM-4GIB2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68487
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37434
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.849681
SNU-C2B	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159561
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.66
abnormal hypodermis morphology	MPO Gene-Phenotype Associations	1.0	null
reticular formation of JcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00054
Perturb_11104_KO_Tsc1_SRP219943	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.762
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.378
Bundle sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.524
behavioral abnormality	GWASdb SNP-Phenotype Associations	1.0	0.09139
SKLU1_LUNG	CCLE Cell Line Proteomics	1.0	2.57765
nafcillin-4103	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
spironolactone-2064	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RBM39	Pathway Commons Protein-Protein Interactions	1.0	null
LOX	Pathway Commons Protein-Protein Interactions	1.0	null
Gastrointestinal Diseases	CTD Gene-Disease Associations	1.0	1.06698
GTEX-WHSB-1826-SM-3TW8M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14964
YAF2	Pathway Commons Protein-Protein Interactions	1.0	null
HEK-293H cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.537
NCI-H2291	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE226249_5_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
adenyl nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.62
HADHB	Pathway Commons Protein-Protein Interactions	1.0	null
independently	GeneRIF Biological Term Annotations	1.0	null
intermediate stratum of r9Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04135
Leptin signaling	WikiPathways Pathways 2024	1.0	null
BRD-K54233340_Dorsomorphin dihydrochloride_U937_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
RPS6	Pathway Commons Protein-Protein Interactions	1.0	null
ChREBP activates metabolic gene expression	Reactome Pathways 2024	1.0	null
GTEX-SNMC-1426-SM-2XCFM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00792
hsa-miR-1305	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Perturb_4992_KO_Mettl5_SRP268611	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.7461
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.22233
GTEX-WRHK-0826-SM-3MJFG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5324
CMK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SNU886	CCLE Cell Line Gene Mutation Profiles	1.0	null
r6 part of spinal trigeminal nucleus, pars oralis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09788
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041493
BRD-K88573743_A443654_HA1E_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MEF2C_MEF2C	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7854-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Neoplasms	CTD Gene-Disease Associations	1.0	1.2368
RPL24	Pathway Commons Protein-Protein Interactions	1.0	null
16168083-Table1	GeneSigDB Published Gene Signatures	1.0	null
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.67217
GSE102870_7_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K40276277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06666
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4834-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_11061_KO_Nbs1_SRP221749	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.73396
abnormal aerobic respiration	MPO Gene-Phenotype Associations	1.0	null
hypercholesterolemia; ldlc levels	GAD Gene-Disease Associations	1.0	null
BRD-K17497770_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HDAC6_KO_GSE27896_383_mouse_Foxp3+ T-regulatory cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Perturb_14699_KO_TET1_SRP251780	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-17.4949
GSE204832_0_v_1_imiquimod_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K78599730_manumycin A_SKLU1_6.0_h_9.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE136742,GSE136744_2_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SARS-CoV MA15_Day7-CXCR3KO_None_GSE50878	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.45598
purine-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
oculomotor nuclear complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07838
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.743954
PARG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32561
nucleus	GO Cellular Component Annotations 2025	1.0	null
BRD-K58025976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13965
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2686
glucose metabolism disease	GWASdb SNP-Disease Associations	1.0	0.290389
acetyl-coa carboxylase activity	GO Molecular Function Annotations 2015	1.0	null
akt	Phosphosite Textmining Biological Term Annotations	1.0	null
Coronary Disease	CTD Gene-Disease Associations	1.0	1.02373
Craniofacial Abnormalities	CTD Gene-Disease Associations	1.0	1.08619
GSE234340_1_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K02590140_O-2050_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC6659998__F3	PFOCR Pathway Figure Associations 2024	1.0	null
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14728
related	GeneRIF Biological Term Annotations	1.0	null
Proteinuria	CTD Gene-Disease Associations	1.0	1.77492
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067142
binds	GeneRIF Biological Term Annotations	1.0	null
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.818993
Brain Lower Grade Glioma_LGG_TCGA-FG-A87Q-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K93123848_RAF 265_HT29_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Diabetes Mellitus	CTD Gene-Disease Associations	1.0	1.47556
metabolic	Phosphosite Textmining Biological Term Annotations	1.0	null
BRD-K75981085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66925
GSE111035,GSE111040_10_v_12_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF667	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5455
Longissimus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.612
BRD-K19554809_MK 212_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCIH1838	CCLE Cell Line Gene Mutation Profiles	1.0	null
Diabetes Complications	HuGE Navigator Gene-Phenotype Associations	1.0	null
malonyl-coa metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-SUCS-1826-SM-32PM1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74415
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
Adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.558
BRD-K47776393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04244
Blood Coagulation Disorders	CTD Gene-Disease Associations	1.0	1.49533
white adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.70108
BRD-K68300789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2349
NCIH716_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	3.71898
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K78431006_HY-50878_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
glucose	Phosphosite Textmining Biological Term Annotations	1.0	null
BRD-K24512597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58666
Hepatopancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.686
BRD-K74402642_Chemistry 2804_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Presubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44892
LY-294002-6186	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Triglycerides	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.752288
UBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15938
organic substance transport	GO Biological Process Annotations 2015	1.0	null
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Coronary Arteriosclerosis	DisGeNET Gene-Disease Associations	1.0	null
LOVO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22392
layer VI of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.48187
MDST8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.38028
BRD-K07859598_Raf1 Kinase Inhibitor I_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
embryonic fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.086204
Childhood Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.6396
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24291
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.50471
RPRD1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50274
BRD-K66889220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08914
PU.1-20513432-BCELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE211226_1_v_0_sirpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cellular nitrogen compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
ClpP/crotonase-like domain	InterPro Predicted Protein Domain Annotations	1.0	null
19139136-TableS3	GeneSigDB Published Gene Signatures	1.0	null
dorsolateral part of m1A	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08865
NFE2L2	ChEA Transcription Factor Targets	1.0	null
lateral terminal nucleus of the accessory optic tract, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.65607
very-low-density lipoprotein particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.22173
GTEX-WFG7-2226-SM-3GIKP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65694
BRD-K47441131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37626
vascular tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.129076
hsa-miR-4281	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
DMS-273	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HIST1H2BM	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH1581	CCLE Cell Line Gene Expression Profiles	1.0	1.4053
BRD-K61934967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10224
diabetes	Phosphosite Textmining Biological Term Annotations	1.0	null
GSE136232,GSE136234_0_v_1_zpbp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_result_of_MR_analysis_and_sensitivity_analysis_for_DLco_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Glucose Intolerance	CTD Gene-Disease Associations	1.0	2.17937
HCC1954	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.34764
GSE207433_0_v_3_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
glycerol-3-phosphate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.419
GSE193258,GSE193259_9_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54383
Hyperglycemia	CTD Gene-Disease Associations	1.0	1.96147
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.428118
lipid biosynthetic process	GO Biological Process Annotations 2025	1.0	null
CA46	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.29623
Interposed nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01701
HCT-116	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KM-8476-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BCL2L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00354857
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.671593
PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_6_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.890919
BRD-K81795824_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
parasubiculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40658
A549_Ofloxacin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128799
A549_UNC1999_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119478
SNU1040	CCLE Cell Line Gene Mutation Profiles	1.0	null
PRKAA1	KEA Substrates of Kinases	1.0	null
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.1
A549_Decitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171373
BRD-K39547688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57749
Prostate adenocarcinoma_PRAD_TCGA-EJ-7781-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.4944
Medial geniculate complex, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42329
Perturb_11288_KO_Dicer_SRP041679	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.2887
SW48	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RPL6	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-NJ-A4YF-01A-12R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044491
metabolic	GAD High Level Gene-Disease Associations	1.0	0.310806
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K50660797_EPICATECHIN MONOGALLATE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BDNF signaling pathway(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
PMC12271188-Table_3.XLSX-CTD-RELA_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
IMR-32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27854
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A7WF-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9287735-mmc2.xlsx-NGR1-target-MI_network-node1_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
MCM5	Pathway Commons Protein-Protein Interactions	1.0	null
state	GeneRIF Biological Term Annotations	1.0	null
structureguided	GeneRIF Biological Term Annotations	1.0	null
fashion	GeneRIF Biological Term Annotations	1.0	null
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889879
19010862-TableS2	GeneSigDB Published Gene Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5478-11A-11R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TUBB3	Pathway Commons Protein-Protein Interactions	1.0	null
Chronic Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.414
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5549-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.891847
Infertility, Male	CTD Gene-Disease Associations	1.0	1.59218
GTEX-OIZH-0226-SM-2YUMH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.910701
superficial stratum of r6Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32392
CAL-33	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Eye Diseases	CTD Gene-Disease Associations	1.0	1.33966
renal tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069981
thyroid gland	HPA Tissue Protein Expression Profiles	1.0	1.16855
dorsomedial preoptic area, intermediate part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.98508
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.35726
Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z2-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
carnitine shuttle	GO Biological Process Annotations 2015	1.0	null
BRD-K78344913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.36806
Arteriosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.569
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.050828
acetylcoenzyme	GeneRIF Biological Term Annotations	1.0	null
Nucleus of the optic tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.45304
Copula pyramidis, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52518
Integration of energy metabolism	Reactome Pathways 2024	1.0	null
resveratrol	CTD Gene-Chemical Interactions	1.0	null
POU3F1-26484290-ESCSS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S2-Table_S2_Full_result_of_MR_estimates_for_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
JUN	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4483	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Sleep Initiation and Maintenance Disorders	CTD Gene-Disease Associations	1.0	1.05498
Presubiculum, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.89101
HCC1599	CCLE Cell Line Gene Mutation Profiles	1.0	null
Plastid stroma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.594
BRD-K30792491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05631
NRF2-20460467-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Pain	CTD Gene-Disease Associations	1.0	1.90919
PMC12271188-Table_3.XLSX-total-RELA_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14847
GSE220813_0_v_1_zfp750_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FGFR1_activemutant_58_GSE17916	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.10603
nerve-tissue-proteins	Phosphosite Textmining Biological Term Annotations	1.0	null
Respiratory chain complex I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.915
GSE181517_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Fat pad	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.354
SNU-475	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CSMD2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K04462989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04986
neurological	GAD High Level Gene-Disease Associations	1.0	0.293278
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043775
CD3G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00556516
GTEX-WHPG-0626-SM-3NMBD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952633
t61-colon_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.7819
BRD-K02822062_CT-200783_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TTBK2	Kinase Library Serine Threonine Kinome Atlas	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29V-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S7SE-0008-SM-33HB1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08937
H3K36me3_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K44416503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03807
GSE65617_0_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mice-transgenic	Phosphosite Textmining Biological Term Annotations	1.0	null
regulation of localization	GO Biological Process Annotations 2015	1.0	null
Perturb_17759_KO_Lin9_SRP221087	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-2689-11A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_IOX2_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210319
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.089
GSE158834_2_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Seizures	CTD Gene-Disease Associations	1.0	1.56582
ginkgolide A-4121	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Copula pyramidis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44706
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913528
GSE147943_5_v_1_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE76771_2_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HT-1197	GDSC Cell Line Gene Expression Profiles	-1.0	-1.71035
BRD-K67319345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55819
GSE237984_1_v_0_magi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6939-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ribonucleotide biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.193
obesity	Phosphosite Textmining Biological Term Annotations	1.0	null
oxidation	Phosphosite Textmining Biological Term Annotations	1.0	null
ventrolateral prefrontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.68572
GRPEL1	Pathway Commons Protein-Protein Interactions	1.0	null
SW1116	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-PWOO-0008-SM-48TDU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07586
epithalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.14177
malonyl-coa biosynthetic process	GO Biological Process Annotations 2015	1.0	null
BRD-A19195498_TRIMIPRAMINE MALEATE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LS180	CCLE Cell Line Gene Mutation Profiles	1.0	null
Dihydrotestosterone	CTD Gene-Chemical Interactions	1.0	null
oxytetracycline-5772	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
depression	GWASdb SNP-Phenotype Associations	1.0	0.359497
amino acid metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.075388
hsa-miR-541	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
lung	Phosphosite Textmining Biological Term Annotations	1.0	null
Invasive cervical cancer	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.852288
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.858
BRD-K28296557_Akt inhibitor IV_NCIH596_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K43341506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13406
BRD-K67578145_S1104_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
propanoate metabolism	KEGG Pathways	1.0	null
GSE157960_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
salivary gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.128332
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.882051
GSE125007,GSE125008_6_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A69B-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCFC2	Pathway Commons Protein-Protein Interactions	1.0	null
SNU1544	DepMap CRISPR Gene Dependency	1.0	5.94112
CENPV	Pathway Commons Protein-Protein Interactions	1.0	null
shoot	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.126116
BRD-K95343362	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.468
GSE174735_4_v_0_il22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE166920_6_v_3_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nucleoside phosphate metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K92301463_-666_PL21_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_Daphnetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175726
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829905
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.426
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K94325918_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
carboxylic acid binding	GO Molecular Function Annotations 2015	1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
PMC9214699__F5	PFOCR Pathway Figure Associations 2024	1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
BRD-K18163752_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
colforsin-913	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A59R-11A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC3761196__F7	PFOCR Pathway Figure Associations 2023	1.0	null
CSTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14564
heterocycle metabolic process	GO Biological Process Annotations 2015	1.0	null
H1-0	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42474
GSE104508_0_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
fatty acid biosynthesis	KEGG Pathways	1.0	null
KMRC-20	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WFJO-1026-SM-3GIKL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04768
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29734
sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.074067
HEC265	CCLE Cell Line Gene Mutation Profiles	1.0	null
GTEX-R55D-0326-SM-48FES	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35941
ALB	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U3ZM-1226-SM-3DB9G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54358
BRD-K05586628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41732
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
pretectal region	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.934152
IPC-298	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.33109
Lobules IV-V, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10324
BRD-K64824710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02775
BL1424 (FOXO1)	NURSA Protein Complexes	1.0	null
colchicine-3213	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K41674016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01642
TBX3	ChEA Transcription Factor Targets	1.0	null
GSE82110,GSE82299_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K78162975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07296
SCMCRM2	DepMap CRISPR Gene Dependency	1.0	2.20316
GSE183251_7_v_5_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LY-294002-1652	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
small molecule metabolic process	GO Biological Process Annotations 2015	1.0	null
PFDN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13158
Female reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.248
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.058577
BRD-A08187463_Racecadotril_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KNS60	Achilles Cell Line Gene Essentiality Profiles	1.0	1.58634
BRD-A84174393_MELOXICAM SODIUM_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE164521_0_v_1_nitric oxide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K44366801_NCGC00182371-01_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Neoplasm Metastasis	CTD Gene-Disease Associations	1.0	1.67976
SHE	Pathway Commons Protein-Protein Interactions	1.0	null
r8 portion of ambiguous motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0158
MOTN1	CCLE Cell Line Gene Mutation Profiles	1.0	null
GSE214161,GSE214233_0_v_2_zmym2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
major	GeneRIF Biological Term Annotations	1.0	null
BRD-K63410075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1365
GTEX-U3ZN-1926-SM-4DXSG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824408
bed nucleus of the stria terminalis, laterocentral division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11657
AML193	Achilles Cell Line Gene Essentiality Profiles	1.0	1.35003
adipose	Phosphosite Textmining Biological Term Annotations	1.0	null
PRKAR1B	Pathway Commons Protein-Protein Interactions	1.0	null
asian	GeneRIF Biological Term Annotations	1.0	null
paracentral lobule, posterior part, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.993604
mRNA_EP400_22196727	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE114258_3_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pregnancy Complications	CTD Gene-Disease Associations	1.0	1.02336
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16774
dorsolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.21727
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Perturb_14960_KO_Tfap4_SRP212619	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.81666
PMC4839647__F3	PFOCR Pathway Figure Associations 2023	1.0	null
GSE203308_4_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GB-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC2943625-supp_gkq287_SupplResults.xls-Result_trips_AR-Target_Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
skeletal muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.385143
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14504
SNU-C5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE143643,GSE143644_3_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
acyl-CoA metabolic process	GO Biological Process Annotations 2023	1.0	null
NADH dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.827
GTEX-WK11-2426-SM-3NMAA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88524
GSE152055_0_v_1_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Metabolic Syndrome X	DisGeNET Gene-Disease Associations	1.0	null
ZC3HAV1	Pathway Commons Protein-Protein Interactions	1.0	null
HEK 293 T-rex    	BioGPS Cell Line Gene Expression Profiles	1.0	1.00198
Liver hepatocellular carcinoma_LIHC_TCGA-EP-A3RK-11A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
skin	HPA Tissue Protein Expression Profiles	-1.0	-1.13812
GSE111385_2_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K93123848_RAF 265_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC12494973-41467_2025_63880_MOESM1_ESM.pdf-93-NEUROG3_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09836
increased circulating triglyceride level	MPO Gene-Phenotype Associations	1.0	null
17410534-Table1	GeneSigDB Published Gene Signatures	1.0	null
PMC10742386-pnas.2311372120.sd05.xlsx-DLX3_EVT-Gene_Symbol_DLX3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE173810_0_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153189_1_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE87299_1_v_0_nr1d1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ESRRG_ESRRG	Rummagene Transcription Factor Associations 2026	1.0	null
HS604T	CCLE Cell Line Gene Mutation Profiles	1.0	null
THBS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39436
organic hydroxy compound transport	GO Biological Process Annotations 2015	1.0	null
GSE48812_3_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Defective MMAB causes methylmalonic aciduria type cblB	Reactome Pathways 2014	1.0	null
phentolamine-4336	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nephropathy	GeneRIF Biological Term Annotations	1.0	null
adaptor-proteins-signal-transducing	Phosphosite Textmining Biological Term Annotations	1.0	null
pharmacological	Phosphosite Textmining Biological Term Annotations	1.0	null
UBE2Q2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03773
BRD-K74710236_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Slow muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.363
BRD-A20697603_T8902_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.843505
Twitch muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.366
positive regulation of developmental growth	GO Biological Process Annotations 2015	1.0	null
retinoblastoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.364513
RCOR3-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PEO4	DepMap CRISPR Gene Dependency	1.0	3.2721
BRD-A63998256_Helveticoside_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Jaundice	CTD Gene-Disease Associations	1.0	1.59264
MAP1A	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH2170	CCLE Cell Line Gene Mutation Profiles	1.0	null
Mitochondrial tricarboxylic acid cycle enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.062
BRD-K02822062_CT-200783_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Feather	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.797
vitamin e_mus musculus_gpl1261_gse42813	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.929517
GSE210580_0_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1395	Achilles Cell Line Gene Essentiality Profiles	1.0	1.094
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.74682
GCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17756
FRMPD4	Pathway Commons Protein-Protein Interactions	1.0	null
SKES1	CCLE Cell Line Gene Expression Profiles	1.0	2.07813
Acute Myeloid Leukemia_LAML_TCGA-AB-3001-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZR-75-30	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Nodulus (X), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.37493
diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.07194
CRCGN011_HEPG2_24H:D14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04665
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.31912
BRD-K83988098_S1142_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
abnormal fatty acid beta-oxidation	MPO Gene-Phenotype Associations	1.0	null
Prestwick-984-6603	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-1913	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
EGR1	ChEA Transcription Factor Targets	1.0	null
COR-L95	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE48812_9_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SKMES1	CCLE Cell Line Gene Mutation Profiles	1.0	null
HSC-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
least	GeneRIF Biological Term Annotations	1.0	null
BRD-K64890080_BI-2536_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.872113
BRD-A83326220_BRAZILIN_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6829-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
soleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.139
GTEX-S341-1826-SM-3K2AB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67527
JUN::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0651
17389037-Tab1	GeneSigDB Published Gene Signatures	1.0	null
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39W-11A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K43336921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31533
STAC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00605768
intermediate stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06664
Disease Progression	HuGE Navigator Gene-Phenotype Associations	1.0	null
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDV3	Pathway Commons Protein-Protein Interactions	1.0	null
Septofimbrial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58797
fastigial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.21369
MYO18A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-VUSG-1426-SM-3GIJN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894836
MRPL15	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K36923996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53153
BRD-K50432649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64567
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.546885
Biotin	HMDB Metabolites of Enzymes	1.0	null
GSE235644_1_v_0_fasn_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8047323-Table_2.xlsx-LPS_PMMA_T24-GeneSymbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Fetal Death	CTD Gene-Disease Associations	1.0	1.78454
GSE203308_7_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
13c4	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.553
BRD-K59626557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49397
Prediabetes syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.567
GSE196699_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
lateral (dentate) cerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0804
variants	GeneRIF Biological Term Annotations	1.0	null
Hypotension	CTD Gene-Disease Associations	1.0	1.78644
BRD-K65598127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2526
Glycogen granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.039
GTEX-O5YV-2026-SM-2D7VS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22838
SIPA1L3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K60080002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56221
GSE240027,GSE240030_5_v_4_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832562
BRD-K17140735_-666_NCIH1694_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
3T3-L1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.799
Salivary Gland Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
DU4475	DepMap CRISPR Gene Dependency	1.0	2.01643
CDC42EP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830321
IPO13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41605
EEF1B2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE213588_9_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-PWCY-2126-SM-48TEC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02026
Brain Diseases	CTD Gene-Disease Associations	1.0	1.29996
Pyruvate metabolism	KEGG Pathways 2026	1.0	null
Bed nuclei of the stria terminalis, anterior division, dorsomedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1235
GSE109913_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
COLO-792	COSMIC Cell Line Gene Mutation Profiles	1.0	null
localization	GO Biological Process Annotations 2015	1.0	null
Intracellular canaliculus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.809
Lobules IV-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04797
binding	GO Molecular Function Annotations 2015	1.0	null
Biotinidase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.303
PMC9232687-13238_2021_887_MOESM3_ESM.xlsx-37_KD_sgCDC20_vs_sgNTC-Differentially_expressed_genes_DEGs_upon_CDC20_knockdown_under_37_culture_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_9_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Embryo Loss	CTD Gene-Disease Associations	1.0	1.04163
GSE240027,GSE240030_1_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-554	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE158834_1_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_InDel-F5-Thygro-r__CIC-1n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
KCNA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37798
BRD-K35960502_NICLOSAMIDE_A673_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
outer CP in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.41405
Lung squamous cell carcinoma_LUSC_TCGA-43-7657-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-90-7767-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE92364_0_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Headache	CTD Gene-Disease Associations	1.0	1.492
decreased glycogen level	MPO Gene-Phenotype Associations	1.0	null
BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mitochondrial part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
RPL19	Pathway Commons Protein-Protein Interactions	1.0	null
laterostriatal stripe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28897
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dorsal thalamus_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.06479
G-292_CLONE_A141B1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Atherosclerosis	CTD Gene-Disease Associations	1.0	2.08645
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05425
ONS-76	GDSC Cell Line Gene Expression Profiles	-1.0	-2.68501
BRD-K92241597_CHR 2797_H1299_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NAV3	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7055-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Anterior group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12697
A549_WP1066_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137002
CW9019	DepMap CRISPR Gene Dependency	1.0	3.33154
BRD-K66270896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.01588
GSE205070_2_v_5_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
extracellular region part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.049471
GSE157555,GSE157556_3_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.942006
hsa-miR-4319	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
Postsubiculum, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60945
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.26512
PSMA3	Pathway Commons Protein-Protein Interactions	1.0	null
PRDM16_DEPLETION_GDS4021_460_mouse_WAT - white adipose tissue (stromal-vascular cells)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.27829
RAN	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-SIU8-0008-SM-4BRUC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03517
stress	Phosphosite Textmining Biological Term Annotations	1.0	null
SMARCD1-25818293-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_12595_KD_Gatad2b_SRP366371	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-13.378
gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
acetyl-CoA metabolic process	GO Biological Process Annotations 2023	1.0	null
BRD-K60044070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19561
RPL7A	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Ki8751_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171345
nucleotide biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GTEX-OOBK-0226-SM-2YUMF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06421
GSE210580_4_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K13571841_Pepstatin A_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H1963	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-208a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
BRD-K65496998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69622
Pancreas	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.16562
orbital frontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.00006
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4163
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100463_FWM_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.23115
leaf lamina	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.576816
nod2_21335489_hek293_lof_human_gpl570_gds4416	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.491804
p38	GeneRIF Biological Term Annotations	1.0	null
thigh	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.714189
growth abnormality	GWASdb SNP-Phenotype Associations	1.0	0.26638
bed nucleus of stria terminalis, lateral amygdaloid division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67417
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Cholestasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
Epididymis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.687
H3F3A	Pathway Commons Protein-Protein Interactions	1.0	null
HEC59	CCLE Cell Line Gene Mutation Profiles	1.0	null
CRCGN014_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.93064
SEC24B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79935
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6914-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE181517_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Uterine Neoplasms	CTD Gene-Disease Associations	1.0	1.04163
GTEX-PWN1-1626-SM-2S1OL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45851
thorax	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05545
Alcoholic hepatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.173
CP-863187-7512	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE209938_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GLTSCR1	Pathway Commons Protein-Protein Interactions	1.0	null
Cardiac muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.827
stratum radiatum of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06309
PMC6452569__F8	PFOCR Pathway Figure Associations 2023	1.0	null
Tcf12	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.3792
BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_MCF7_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K51313569_palbociclib_HS578T_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Hemorrhage	CTD Gene-Disease Associations	1.0	1.51531
mantle zone of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.62749
SGOL2	Pathway Commons Protein-Protein Interactions	1.0	null
lateral terminal nucleus of the accessory optic tract, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.03201
KMS-21BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.52046
BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pectoral muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.437
H3K27me3_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059477
pulp	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.255733
GTEX-UTHO-1026-SM-3GAF7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14803
Agenesis	DisGeNET Gene-Disease Associations	1.0	null
MTRF1	Pathway Commons Protein-Protein Interactions	1.0	null
Carbamoyl-phosphate synthase, large subunit, N-terminal	InterPro Predicted Protein Domain Annotations	1.0	null
SUP-B15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.44725
Measles Chicago-1_24Hour_16492729_GSE980	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.36362
regulation of multicellular organismal process	GO Biological Process Annotations 2015	1.0	null
BRD-K24133999	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45751
Fatty Liver	DisGeNET Gene-Disease Associations	1.0	null
496100461_PCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.71504
Fatty Liver Disease	DisGeNET Gene-Disease Associations	1.0	null
Congenital Abnormalities	CTD Gene-Disease Associations	1.0	1.09297
GSE252857_1_v_3_klf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K81647247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02759
16474848-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
PRKAA1	Pathway Commons Protein-Protein Interactions	1.0	null
cellular phenotype	MPO Gene-Phenotype Associations	1.0	null
adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.139
EVI2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00699434
BRD-K58347372_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SYNE1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7617064-EMS151900-supplement-Figure_7_Source_Data.xlsx-HLC_D9_DEG-Logfold_change_threshold_1_0_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
EHHADH	Pathway Commons Protein-Protein Interactions	1.0	null
GSE200673,GSE200691_2_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XQ8I-1426-SM-4BOPW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916479
PTBP1	Pathway Commons Protein-Protein Interactions	1.0	null
HRT18	CCLE Cell Line Gene Mutation Profiles	1.0	null
maintain	GeneRIF Biological Term Annotations	1.0	null
BRD-K61717269_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K49328571_dasatinib_HME1_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
small molecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.928714
JARID1B-DAIN-22020125-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE88819_0_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MEG-01	GDSC Cell Line Gene Expression Profiles	-1.0	-1.9358
vertebrate muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE120370_0_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-1182	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
coenzyme a biosynthetic process	GO Biological Process Annotations 2015	1.0	null
TRABD2A	Pathway Commons Protein-Protein Interactions	1.0	null
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.12578
regulation of organ growth	GO Biological Process Annotations 2015	1.0	null
BRD-K32828673_Chelidonine (+)_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.5
19658189-TableS3	GeneSigDB Published Gene Signatures	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-3012-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
TUFM	Pathway Commons Protein-Protein Interactions	1.0	null
Amylin receptor complex 1	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.61
abnormal circulating leptin level	MPO Gene-Phenotype Associations	1.0	null
JEKO-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
NCI H322M	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.896971
GTEX-POMQ-0008-SM-48TE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.10554
PA-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
tubular	GeneRIF Biological Term Annotations	1.0	null
SH3RF1	Pathway Commons Protein-Protein Interactions	1.0	null
HEC1A	CCLE Cell Line Gene Mutation Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5887-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NOMO1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.53494
TC-71	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.57711
GTEX-QDVN-2426-SM-2S1Q4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02829
digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE120216_3_v_0_cbfb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PC	Pathway Commons Protein-Protein Interactions	1.0	null
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5047
U937	CCLE Cell Line Gene Expression Profiles	1.0	1.34883
central nucleus of the inferior colliculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28729
an3ca	HPA Cell Line Gene Expression Profiles	1.0	0.854169
BRD-K76350099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22193
UQCRFS1	Pathway Commons Protein-Protein Interactions	1.0	null
export	Phosphosite Textmining Biological Term Annotations	1.0	null
BRD-K24132293_PIPLARTINE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Chronic kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.379
PRKCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31094
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.3629
hnf4a_16714383_e18dot5_liver_lof_mouse_gpl1261_gds1916	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.140215
HNF4	MotifMap Predicted Transcription Factor Targets	1.0	null
parenchyma	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.393819
LS-180	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Peroxisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.291
Field CA2, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12162
BRD-K12710356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10509
BRD-K11927976_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04361
BRD-A19500257_geldanamycin_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC7181746-41467_2020_15886_MOESM8_ESM.xlsx-Patient_9_CCF-Affected_Genes_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K36me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	2.11494
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051231
Infertility, Female	CTD Gene-Disease Associations	1.0	1.12391
nucleus	Phosphosite Textmining Biological Term Annotations	1.0	null
GSE216273,GSE216292_0_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202603_3_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-511	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
phosphorus metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K76703230_YM-155_HA1E_6.0_h_0.31_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOXO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07593
decreased body weight	MPO Gene-Phenotype Associations	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8Q9-01A-12R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hyperkinesis	CTD Gene-Disease Associations	1.0	1.20622
ANKRD28	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X5EB-2426-SM-4E3HX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07028
BRD-K99455613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65698
A549_PCI-34051_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142765
EFM19	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.68151
Liver hepatocellular carcinoma_LIHC_TCGA-QA-A7B7-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35689
dose-dependent	Phosphosite Textmining Biological Term Annotations	1.0	null
TCF4	ChEA Transcription Factor Targets	1.0	null
BRD-K12260399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5915
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_4_FDC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
monorden-1160	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRWD1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6628043__F7	PFOCR Pathway Figure Associations 2023	1.0	null
thioridazine-4164	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
transient Purkinje cell clusters	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.824149
dehydrogenase	Phosphosite Textmining Biological Term Annotations	1.0	null
abnormal glucose homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.218012
PMC9385264-NIHMS1828071-supplement-8.xlsx-AR-gene_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
alpha-estradiol-6169	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22765
Slow twitch muscle fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.187
GSE132386_2_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r3 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28779
BRD-K22537050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18392
hippocampus (hippocampal formation)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13942
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.85415
homeostasis/metabolism phenotype	MPO Gene-Phenotype Associations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A17X-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KRT16	Pathway Commons Protein-Protein Interactions	1.0	null
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
small molecule binding	GO Molecular Function Annotations 2015	1.0	null
medial geniculate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41899
nitric	Phosphosite Textmining Biological Term Annotations	1.0	null
COMPOUND 21 [PMID: 23981033]	DGIdb Drug Targets 2026	1.0	2.2055
positive regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
ZR7530	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.04335
GSE228181_3_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
layer 2 of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23679
BRD-K77743611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27553
CRCGN015_MCF10A.TP53.M_24H:L21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5873
physostigmine-1776	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC9170821-JCMM-26-3183-s001.xlsx-Neu_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_16832_OE_Myc_SRP250081	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.29665
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28014
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
prethalamic eminence	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13031
HPAFII	CCLE Cell Line Gene CNV Profiles	1.0	1.82874
r9 part of ventral parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03971
mice-inbred-c57bl	Phosphosite Textmining Biological Term Annotations	1.0	null
ML-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K05154886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82481
BRD-M86331534_BJM-ctd2-9_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K64642496_-666_HT29_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36551
purine nucleoside biosynthetic process	GO Biological Process Annotations 2015	1.0	null
CTNNA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19664
adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052055
GTEX-NFK9-0326-SM-3MJGV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12253
MCTP2	Pathway Commons Protein-Protein Interactions	1.0	null
partly	GeneRIF Biological Term Annotations	1.0	null
Acquired Immunodeficiency Syndrome	HuGE Navigator Gene-Phenotype Associations	1.0	null
JHUEM7	CCLE Cell Line Gene Mutation Profiles	1.0	null
GTEX-XUZC-1826-SM-4BRVO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80541
hsa-miR-4512	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE188870,GSE188871_4_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K86574132_-666_SW480_6.0_h_48.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
program	GeneRIF Biological Term Annotations	1.0	null
positive regulation of growth	GO Biological Process Annotations 2015	1.0	null
GTEX-S341-0008-SM-4AD6D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870115
pericarp	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.313683
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.164045
MGA::EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3252
GSE189683_3_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Alcoholic liver disease	KEGG Pathways 2026	1.0	null
PPARGC1B_Hypomorphic Mutation_GDS2515_695_mouse_Skeletal muscle - (quadriceps muscles)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Hyperlipoproteinemias	CTD Gene-Disease Associations	1.0	1.15593
PMC8853518-pcbi.1009800.s007.xlsx-M_Fatty_Acid_PPAR-Unnamed_4_PPARA	Rummagene Transcription Factor Associations 2026	1.0	null
locus	GeneRIF Biological Term Annotations	1.0	null
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.72985
anteroventral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.80516
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8518
pancreatic beta cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.249977
YAP1-20516196-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-4768-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
RCC10RGB	DepMap CRISPR Gene Dependency	1.0	2.23705
Perturb_13216_KO_Dnmt3b_SRP063529	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	15.3275
isoetharine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69165
EPC1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9541747-AGE-53-680-s003.xlsx-TableS6-Table_S6_Genes_with_missense_mutations_in_Yaroslavl_cattle_MAF_0_1_and_FST_0_4_in_the_1000_Bull_Genomes_Run_9_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
CAL-120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36824
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.963658
PMC10773028-40364_2023_552_MOESM1_ESM.xlsx-Variants_sheet-TFT_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
glut4	Phosphosite Textmining Biological Term Annotations	1.0	null
KDM2B-26808549-CHIP-SEQ-HPB-ALL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-A26711594_NICARDIPINE HYDROCHLORIDE_U937_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
r10 part of nucleus gracilis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46413
NR1I2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7475
PMC10248509-Data_Sheet_6.CSV--GSE58294_DE-genes_AND_GSE22255_DE-Genes_NOT_Autophagy_NOT_GSE66724_DE-Genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5040-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE205332_1_v_0_queuine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
k562	HPA Cell Line Gene Expression Profiles	-1.0	-1.35755
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	6.33545
HCC1599	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CP-640186	DGIdb Drug Targets 2026	1.0	2.2055
HT-29	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MG-63	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K76788397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29367
H3K27me3_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
acetyl	GeneRIF Biological Term Annotations	1.0	null
normal	GeneRIF Biological Term Annotations	1.0	null
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.207
nialamide-3790	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.37271
TNFRSF25	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00459994
anion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GSE179031_0_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K16682693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05153
496100438_PCx_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.21647
GTPBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20537
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.171
adipose tissue	HPA Tissue Gene Expression Profiles	1.0	2.24804
BRD-K64052750_gefitinib_MCF10A_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-371b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Meibomian gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.607
PMC5838194__F3	PFOCR Pathway Figure Associations 2024	1.0	null
BL4650 (KIF22)	NURSA Protein Complexes	1.0	null
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
fatty liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.324823
establishment of localization in cell	GO Biological Process Annotations 2015	1.0	null
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.974772
cellular lipid metabolic process	GO Biological Process Annotations 2015	1.0	null
Human - Adipose - L2 - hAd2	HuBMAP Azimuth Cell Type Annotations	1.0	null
CALD1	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH23	Achilles Cell Line Gene Essentiality Profiles	1.0	1.18734
CAMA1	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.921748
GTEX-RVPV-0008-SM-47JYW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22411
Neoplasms	CTD Gene-Disease Associations	1.0	1.88688
retinoblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.178126
Kidney renal papillary cell carcinoma_KIRP_TCGA-DZ-6131-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.83823
carbohydrate derivative binding	GO Molecular Function Annotations 2015	1.0	null
GSE157960_2_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LAMA2_Deficiency_GDS1778_747_mouse_Diaphragm (from dystrophia muscularis -dy/dy- mouse model)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
HCC1143	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-2.17079
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46H-01A-31R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Jugular vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.192
BRD-K39419290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05126
SW900	CCLE Cell Line Gene Mutation Profiles	1.0	null
GSE156454_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
Phosphopyruvate hydratase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.886
PMC5629025-elife-27159-fig1-data1.xlsx-Direct_AR_target_genes-Control_only_genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88893
SIGLEC14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00621555
PANC1005	CCLE Cell Line Gene Mutation Profiles	1.0	null
LGALS1	Pathway Commons Protein-Protein Interactions	1.0	null
oculomotor nucleus, main part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09079
hypercholesterolemia	GAD Gene-Disease Associations	1.0	null
CCK81	CCLE Cell Line Gene Mutation Profiles	1.0	null
lipid	GeneRIF Biological Term Annotations	1.0	null
GTEX-WFON-1226-SM-3TW8F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.997621
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HJ-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of VTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41899
protein homotetramerization	GO Biological Process Annotations 2025	1.0	null
UMUC1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55362
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.887496
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.851
Lung squamous cell carcinoma_LUSC_TCGA-77-7142-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW403	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ampactivated	GeneRIF Biological Term Annotations	1.0	null
IZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.52019
Cell Transformation, Neoplastic	CTD Gene-Disease Associations	1.0	1.86924
Urinary Bladder Neoplasms	CTD Gene-Disease Associations	1.0	1.57546
BRD-K59272984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22213
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE216147_0_v_1_rbm20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6452569__F8	PFOCR Pathway Figure Associations 2024	1.0	null
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.876212
distribution	GeneRIF Biological Term Annotations	1.0	null
BRD-U64521890_XMD16-144_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K99803997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04945
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A119-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Head and neck cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08578
cterminus	GeneRIF Biological Term Annotations	1.0	null
PMC4060771-170289.f1.pdf-622-NEUROD1_NEUROD1	Rummagene Transcription Factor Associations 2026	1.0	null
IRF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.25
SREBP1-19666523-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
WM3211	DepMap CRISPR Gene Dependency	1.0	2.23089
EW-1	GDSC Cell Line Gene Expression Profiles	1.0	1.60215
triangular septal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.84797
GSE86507,GSE86509_7_v_2_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217132_0_v_1_pfkfb4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
mitochondrial membrane	GO Cellular Component Annotations 2015	1.0	null
BRD-K17705806_JTC 801_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Methylmalonic acidemia cblB type	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.311
adipose tissue phenotype	MPO Gene-Phenotype Associations	1.0	null
Dental Plaque	DisGeNET Gene-Phenotype Associations	1.0	null
OVCAR-8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HUP-T3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.19301
inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.901892
PMC10993494__F9	PFOCR Pathway Figure Associations 2024	1.0	null
DND-41	COSMIC Cell Line Gene Mutation Profiles	1.0	null
XKRX	Pathway Commons Protein-Protein Interactions	1.0	null
diabetic	GeneRIF Biological Term Annotations	1.0	null
SQRDL	Pathway Commons Protein-Protein Interactions	1.0	null
Glutaminase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.095
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.50242
GTEX-T2YK-0005-SM-32QOV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.976874
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYC-20876797-MEDULLOBLASTOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ester	Phosphosite Textmining Biological Term Annotations	1.0	null
Inflammation	CTD Gene-Disease Associations	1.0	2.4202
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48824
Weight Gain	CTD Gene-Disease Associations	1.0	2.26071
IZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.92051
NCI-H322M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_10596_KO_Nr1h3/Nr1h2_SRP351084	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.6691
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.245
SK-NEP-1	GDSC Cell Line Gene Expression Profiles	1.0	2.30398
PMC12271601-mmc2.xlsx-OUT_cells_01-Gene_Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Resveratrol_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158078
Defective MMAA causes methylmalonic aciduria type cblA	Reactome Pathways 2014	1.0	null
TAF1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42552
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14728
GSE146074_0_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A45333398_PERIPLOCYMARIN_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HNRNPF	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K04887706_AKT-inhibitor-1-2_MCF10A_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.77109
ventrolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1848
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.10281
GSE173873_8_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_9545_KO_Ucp1_SRP187003	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.67525
GTEX-XUW1-0826-SM-4BOP6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18904
GTEX-XUZC-2126-SM-4BRW8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34586
Ovarian Neoplasms	CTD Gene-Disease Associations	1.0	1.33434
gastrocnemius	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.458373
GSE121809_1_v_0_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
tissue culture	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.8601
coenzyme metabolic process	GO Biological Process Annotations 2015	1.0	null
UBE2F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2309
TENC1	Pathway Commons Protein-Protein Interactions	1.0	null
colon	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.850585
GTEX-QLQW-1226-SM-2S1Q9	GTEx Tissue Sample Gene Expression Profiles	1.0	2.32548
GSE146074_9_v_11_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MFE319	CCLE Cell Line Gene Mutation Profiles	1.0	null
impaired	Phosphosite Textmining Biological Term Annotations	1.0	null
GSE92364_0_v_3_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE139455_0_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_16639_KO_Tardbp_SRP278199	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.35401
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68941
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.19433
skeletal muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-QV31-0008-SM-447AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93696
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5267
ZNF586	Pathway Commons Protein-Protein Interactions	1.0	null
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ADNP	Pathway Commons Protein-Protein Interactions	1.0	null
GSE221327_10_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
UBA1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K73479560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17856
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29763
BRD-K89853033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27162
GSE250560_1_v_0_foxo1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pyruvate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.886
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
amygdaloid complex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.951491
EW8	CCLE Cell Line Gene Expression Profiles	1.0	1.57406
GTEX-WCDI-0002-SM-3P61U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858773
PMC8410083-elife-65574-fig7-data1.xlsx-KLF10_network-Unnamed_25_KLF10	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K39499927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56811
ins-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.553683
Hypopharyngeal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
within	GeneRIF Biological Term Annotations	1.0	null
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Biotin carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.721
KLF10	Pathway Commons Protein-Protein Interactions	1.0	null
adipocytokine signaling pathway	KEGG Pathways	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XD-01A-22R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATP5O	Pathway Commons Protein-Protein Interactions	1.0	null
Alopecia	CTD Gene-Disease Associations	1.0	1.31927
BRD-K87176777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02015
NCIH1435	CCLE Cell Line Gene Mutation Profiles	1.0	null
EPS8	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H226Br cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.88
CP66-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
JAK2_druginhibition_167_GSE38335	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-3.30393
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6467-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
vascular bundle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.137093
Perturb_10813_KO_Xbp1_SRP197108	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.36074
cinchocaine-4149	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormal aerobic respiration	MGI Mouse Phenotype Associations 2023	1.0	null
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE145628,GSE145629_1_v_0_myrf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
C20orf57	Pathway Commons Protein-Protein Interactions	1.0	null
SERTAD4	Pathway Commons Protein-Protein Interactions	1.0	null
MRGBP	Pathway Commons Protein-Protein Interactions	1.0	null
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.486
TTK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58584
PMC10810548-pone.0289518.s002.xlsx-SOM_w_identifiers-target_gene_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
Memory Disorders	CTD Gene-Disease Associations	1.0	1.69103
GTEX-XUJ4-1926-SM-4BOOV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86397
GSE213588_9_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_INO-1001_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178238
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.63072
GTEX-XMK1-0008-SM-4GICF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838061
UMUC1	CCLE Cell Line Gene Mutation Profiles	1.0	null
GSE210662_2_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.79694
GSE248634_1_v_0_gnas_human	RummaGEO Gene Perturbation Signatures	1.0	null
epithelial	GeneRIF Biological Term Annotations	1.0	null
A549_Azacitidine_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165082
Perturb_5514_KO_Spl_SRP345293	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.6689
GTEX-U8XE-1026-SM-4E3HM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.846198
SKMM2	CCLE Cell Line Gene Expression Profiles	1.0	1.62405
Fatty Acid Biosynthesis(Mus musculus)	WikiPathways Pathways 2014	1.0	null
FOSL2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE214335_1_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8144624-41598_2021_90212_MOESM2_ESM.xlsx-3_hrs_ps_LPS-Duck_gene_name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
fat	Phosphosite Textmining Biological Term Annotations	1.0	null
Perturb_11105_KO_Tsc1/Depdc5_SRP219943	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
PMC7452054-mmc1.docx-28-FOXG1_FOXG1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K22137463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48571
TBK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00482366
BRD-K86930074_S1017_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K74302837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02727
Non-Alcoholic Fatty Liver Disease	DisGeNET Gene-Disease Associations	1.0	null
Steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.414
SKNFI	CCLE Cell Line Gene CNV Profiles	1.0	1.49905
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.89286
TBC1D3K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17517
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
GTEX-QDVJ-0005-SM-2TC5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02435
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.611
EXO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00651873
GSE172016_2_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216757_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226091,GSE226092_0_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WH7G-2226-SM-3NMBN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72852
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.55
increased circulating insulin level	MPO Gene-Phenotype Associations	1.0	null
infection	GAD High Level Gene-Disease Associations	1.0	0.293278
GSE158834_0_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
DJM-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
protein-kinase-c	Phosphosite Textmining Biological Term Annotations	1.0	null
oxidation-reduction process	GO Biological Process Annotations 2015	1.0	null
GSE131649_4_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U8XE-0005-SM-3DB8I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.992183
Uterine disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.248
creactive	GeneRIF Biological Term Annotations	1.0	null
Metabolism	Reactome Pathways 2014	1.0	null
superior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.62928