association dataset threshold value standardized value NCI-H1915 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08408 abnormality of the genital system GWASdb SNP-Phenotype Associations 1.0 0.08912 N-Stearoylsphingosine HMDB Metabolites of Enzymes 1.0 null erythroid cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.858837 Brain Lower Grade Glioma_LGG_TCGA-DB-5277-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELF1-20517297-JURKAT-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Ventral premammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46794 CFLAR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26602 3-O-Sulfogalactosylceramide (d18:1/18:1(9Z)) HMDB Metabolites of Enzymes 1.0 null nuclear outer membrane-endoplasmic reticulum membrane network COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 blast cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.062922 PMC10154349-41418_2023_1142_MOESM6_ESM.xlsx-Sheet1-Supplementary_data_3_Genes_positively_correlated_with_HOXC13-AS_in_skin_granular_cells_correlation_coefficients_cor_0_FDR_0_05_HOXC13 Rummagene Transcription Factor Associations 2026 1.0 null MCC13 COSMIC Cell Line Gene Mutation Profiles 1.0 null COLO-704 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.2909 Hair follicle outer root sheath TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.935 ca2oinduced GeneRIF Biological Term Annotations 1.0 null Allergic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.109 upper limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10348 GTEX-WRHK-1426-SM-3MJF9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.38449 outer portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07682 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.492 NEMF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9128 SH3BP5L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08912 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null esophagus HPA Tissue Protein Expression Profiles 1.0 1.48737 NAV2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76978 epithelial cell differentiation GO Biological Process Annotations 2015 1.0 null GTEX-RM2N-1426-SM-2TF4H GTEx Tissue Sample Gene Expression Profiles 1.0 1.67227 Acute Myeloid Leukemia_LAML_TCGA-AB-2943-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC2279 CCLE Cell Line Gene CNV Profiles 1.0 1.50463 Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUP-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STX16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0023 CRY2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94589 RSV-A2_24Hour-KO_RSV_None_GSE18170 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.90337 GTEX-XBED-2226-SM-47JYQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.17949 JUN ChEA Transcription Factor Targets 1.0 null abnormal hair follicle bulge morphology MGI Mouse Phenotype Associations 2023 1.0 null RAB40A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99315 PNMA6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48356 CNFN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04028 facial motor nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.967046 Small intestine mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.766 Endoplasmic reticulum subcompartment COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 RCBTB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33828 hsa-miR-1293 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 SHISA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.16347 r3 roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.72362 COR-L32 COSMIC Cell Line Gene Mutation Profiles 1.0 null KMS-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.855814 ATXN7L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36515 developmental process GO Biological Process Annotations 2015 1.0 null Galactosylceramide (d18:1/18:0) HMDB Metabolites of Enzymes 1.0 null GlobusPallidus BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.879131 CTSL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23393 TMEM39A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5118 VMA21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84069 mantle zone of VTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02224 P2RX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01295 SARS-CoV MA15_Day1-PFU-10^3_None_GSE33266 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.39728 DDX43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00817 SMAD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33468 mantle zone of AStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39682 GTEX-RTLS-1126-SM-46MUQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.946284 BCPAP DepMap CRISPR Gene Dependency 1.0 2.53002 dorsolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.3012 VZ in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.28153 mediated GeneRIF Biological Term Annotations 1.0 null Cer(d18:0/18:1(9Z)) HMDB Metabolites of Enzymes 1.0 null LUC7L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92546 ATXN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94863 VAPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32708 primary motor cortex (area M1, area 4)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.16708 GTEX-Q2AG-0126-SM-33HBV GTEx Tissue Sample Gene Expression Profiles 1.0 1.28657 GTEX-OIZH-0626-SM-3NB1L GTEx Tissue Sample Gene Expression Profiles 1.0 0.855722 GSE174751_0_v_1_postn_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCIH1650 CCLE Cell Line Gene CNV Profiles -1.0 -2.40121 preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.72439 GTEX-WFON-1926-SM-3LK7L GTEx Tissue Sample Gene Expression Profiles 1.0 1.01949 ventral juxtacommissural pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.558 HOPX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89516 PGM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00267 Brain Lower Grade Glioma_LGG_TCGA-DU-5847-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null keratinocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.484766 GSE174735_4_v_3_il22_mouse RummaGEO Gene Perturbation Signatures -1.0 null polyol metabolic process GO Biological Process Annotations 2015 1.0 null striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.921126 PIGH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60558 anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01314 delayed skin barrier formation MGI Mouse Phenotype Associations 2023 1.0 null Disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.77 GTEX-X585-2426-SM-46MW2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.80295 DGKK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9618 CDR2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43382 periventricular stratum of AStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19481 Gustatory areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55306 lymph node HPA Tissue Protein Expression Profiles -1.0 -1.44641 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JY-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WH7G-2326-SM-3NMBC GTEx Tissue Sample Gene Expression Profiles 1.0 1.19599 RELA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51309 SLC27A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8402 GTEX-XYKS-1426-SM-4BRUO GTEx Tissue Sample Gene Expression Profiles 1.0 1.14828 LACTB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99515 PMC10214295-mmc4.xlsx-A_-_Human_Islets_ZBTB16_targets-Gene_Name_ZBTB16 Rummagene Transcription Factor Associations 2026 1.0 null response to calcium ion GO Biological Process Annotations 2015 1.0 null SIN3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79896 Brain Lower Grade Glioma_LGG_TCGA-DU-A76L-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SNMC-1226-SM-2XCFP GTEx Tissue Sample Gene Expression Profiles 1.0 1.8998 Perturb_6658_KO_Egfr_SRP188688 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.59874 Uterine Carcinosarcoma_UCS_TCGA-N5-A4RV-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COQ5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51814 ENG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03256 POLE4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46165 PER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52683 GSE130081,GSE130082_0_v_10_neil2_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC8755441-mmc3.xlsx-IRF7-Up-ezh2_IRF7 Rummagene Transcription Factor Associations 2026 1.0 null HUP-T3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.85051 MRGBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17353 intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 KRTCAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36368 HUPT3 CCLE Cell Line Gene CNV Profiles 1.0 2.39292 esophagus HPA Tissue Gene Expression Profiles 1.0 1.25888 hyperkeratosis MGI Mouse Phenotype Associations 2023 1.0 null APOC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24906 CCLFUPGI0005T DepMap CRISPR Gene Dependency 1.0 2.36403 TUT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56784 GSE68156_0_v_5_dextran_mouse RummaGEO Drug Perturbation Signatures 1.0 null Sarcoma_SARC_TCGA-DX-A23V-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MBD3L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65319 SARS-CoV NSP16_Day7_None_GSE49263 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.52545 CARNS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79548 Brain Lower Grade Glioma_LGG_TCGA-DU-6407-02B-11R-A36H-07,TCGA-DU-6407-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ACSF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.096 amygdaloid complex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.956334 ETS1-22383799-G1ME-MOUSE ChEA Transcription Factor Targets 2022 1.0 null THRB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71734 DNAJC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90933 abnormal skin adnexa morphology MPO Gene-Phenotype Associations 1.0 null Cer(t18:0/16:0) HMDB Metabolites of Enzymes 1.0 null NR1D1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.8386 superficial stratum of PO1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56966 SLC25A46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83538 PCGF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99894 Sarcoma_SARC_TCGA-3B-A9HI-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SSTR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42923 Cornified envelope COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.385 SUPT20H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74017 PI4K2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78769 ARMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66715 PMC4367834-12864_2014_6889_MOESM9_ESM.xlsx-Network_Parkinson_s_Disease-TBP_TBP Rummagene Transcription Factor Associations 2026 1.0 null GTEX-T6MO-1226-SM-4DM5S GTEx Tissue Sample Gene Expression Profiles 1.0 0.886243 hippocampus (hippocampal formation)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.25469 LCOR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77563 keratinocyte differentiation GO Biological Process Annotations 2023 1.0 null SOX12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31087 MDAMB134VI CCLE Cell Line Gene Expression Profiles 1.0 2.65387 ventral tier of thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03252 EW7 DepMap CRISPR Gene Dependency 1.0 2.19186 Sphingolipid catabolism Reactome Pathways 2024 1.0 null PE01 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35996 496100541_FWM_possible Alzheimer's disease_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.0231 Trihexosylceramide (d18:1/26:1(17Z)) HMDB Metabolites of Enzymes 1.0 null paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.913777 zona incerta complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18807 Perturb_4585_KO_Socs3_SRP074146 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 13.314 m1Lim part of the midbrain reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13055 GTEX-TKQ1-0326-SM-4DXSM GTEx Tissue Sample Gene Expression Profiles 1.0 0.948363 keratinocyte differentiation GO Biological Process Annotations 2015 1.0 null GTPBP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39327 Gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.266 FU97 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35996 TP63 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.5961 URI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10488 sphingolipid catabolic process GO Biological Process Annotations 2015 1.0 null GSE200673,GSE200691_2_v_3_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF420 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4481 BMI1-19503595-MEFSC-MOUSE ChEA Transcription Factor Targets 2022 1.0 null LMO2-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null RET_mutant_23_GDS3319 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.63769 H3K4me1_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null T47D CCLE Cell Line Gene Expression Profiles 1.0 2.32802 AUNIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3116 3-O-Sulfogalactosylceramide (d18:1/20:0) HMDB Metabolites of Enzymes 1.0 null cellular response to metal ion GO Biological Process Annotations 2023 1.0 null CDKN1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49067 Palmitoyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.084 CAMKK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58892 organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.28 ZMYM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34683 KLHL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65758 Endexine COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.344 PC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.41193 GTEX-QVJO-1626-SM-2S1QW GTEx Tissue Sample Gene Expression Profiles 1.0 1.42449 CD24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7951 diol biosynthetic process GO Biological Process Annotations 2025 1.0 null Hereditary spastic paraplegia 46 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.678 Procyclic form TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.649 abnormal skin physiology MGI Mouse Phenotype Associations 2023 1.0 null sphingolipid catabolic process GO Biological Process Annotations 2025 1.0 null CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.40641 disease of cellular proliferation GWASdb SNP-Disease Associations 1.0 0.03835 TPI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62999 klf7_17123745_olfactory_epithelium_lof_mouse_gpl1261_gds2069 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -2.96143 GAL3ST3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.20009 Metabolism of lipids Reactome Pathways 2024 1.0 null Sebaceous gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.347 KMS28BM CCLE Cell Line Gene Expression Profiles 1.0 1.50518 Pentadecanoic acid HMDB Metabolites of Enzymes 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2800-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KMT5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38019 PMC9195629-Table1.xlsx-Supplementary_Table_1-JUN_JUN Rummagene Transcription Factor Associations 2026 1.0 null Trihexosylceramide (d18:1/24:1(15Z)) HMDB Metabolites of Enzymes 1.0 null CSDE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95695 Placenta TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 increased carbon dioxide production MPO Gene-Phenotype Associations 1.0 null keratinocytes GeneRIF Biological Term Annotations 1.0 null mantle zone of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04216 NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0485 496100488_TCx_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.10824 Lactosyceramide (d18:1/18:1(9Z)) HMDB Metabolites of Enzymes 1.0 null FKBP1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02496 EIF4A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30403 PMC3339861__F3 PFOCR Pathway Figure Associations 2023 1.0 null GTEx Ovary 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures 1.0 4.79843 Pallidum, dorsal region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25492 Galactosylceramide (d18:1/20:0) HMDB Metabolites of Enzymes 1.0 null Nematocyst COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.561 RALGAPB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83676 superficial stratum of r8BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26642 Cer(d18:0/22:1(13Z)) HMDB Metabolites of Enzymes 1.0 null GTEX-UPK5-0426-SM-3GAEK GTEx Tissue Sample Gene Expression Profiles 1.0 1.05757 GTEX-Q2AI-1326-SM-2S1PL GTEx Tissue Sample Gene Expression Profiles 1.0 1.30657 19605494-TableS3 GeneSigDB Published Gene Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A46B-01A-31R-A250-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.08429 MYC ENCODE Transcription Factor Targets 1.0 null Autosomal recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.34 MDAMB175VII CCLE Cell Line Gene Expression Profiles 1.0 1.54464 Posterior parietal association areas, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51576 TGFB1I1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33031 SEZ6L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28474 rbm15_22490678_hematopoietic_stem_cell_lof_mouse_gpl8321_gds4315 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.052848 EDC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40896 lateral ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.977096 GTEX-X8HC-0626-SM-4E3HQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.12782 dorsolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.858853 Pupal wing TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.916 primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.997441 ZNF48 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93455 UT7 CCLE Cell Line Gene CNV Profiles 1.0 3.2803 GSE60837_0_v_3_bcl9_mouse RummaGEO Gene Perturbation Signatures 1.0 null mantle zone of m2AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61537 RGS19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85705 GTEX-RWS6-2026-SM-2XCB5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.52892 GSE207514,GSE207515_2_v_3_acetylcysteine_human RummaGEO Drug Perturbation Signatures -1.0 null r1 part of vestibular nucleus Y Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00805 abnormal retina morphology MGI Mouse Phenotype Associations 2023 1.0 null RIMS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30722 GTEX-QV44-1926-SM-2S1RF GTEx Tissue Sample Gene Expression Profiles 1.0 1.52868 TCEAL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23092 GTEX-XOT4-0626-SM-4B66L GTEx Tissue Sample Gene Expression Profiles 1.0 1.38411 PMC12178384-mmc5.xlsx-Sheet1-Supp_Table_3_Differential_expression_analysis_of_CIC-rearranged_sarcomas_vs_Ewing_sarcomas_CIC Rummagene Transcription Factor Associations 2026 1.0 null ALX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43293 Lobule II, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01669 Intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.282 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO Molecular Function Annotations 2025 1.0 null lipid catabolic process GO Biological Process Annotations 2015 1.0 null posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.07338 KLF4-19030024-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null Connective tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.085 TK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30626 Skeletal Muscle Female Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -0.949078 Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.211 Anteromedial visual area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37652 TRIM52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00067 GTEX-PSDG-0226-SM-33HC1 GTEx Tissue Sample Gene Expression Profiles 1.0 2.553 DNAJC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41909 PSMF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27159 CECR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9119 GTEX-WFG8-2126-SM-3GIKQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.979695 outer SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.836169 sphingosine metabolic process GO Biological Process Annotations 2015 1.0 null TMCO6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46299 sphingosine biosynthetic process GO Biological Process Annotations 2015 1.0 null GSE159937_2_v_0_tfcp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null TRIR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33316 HS6ST1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94448 abnormal retina morphology IMPC Knockout Mouse Phenotypes 1.0 null magnocellular interstitial nucleus of the posterior commissure Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10697 NCIH929 CCLE Cell Line Gene CNV Profiles 1.0 1.64748 ADCK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63871 Alopecia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.241 STXBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78572 Perturb_9777_KO_Mettl6_ERP120512 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -10.0302 VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.83388 lateral orbital frontal cortex (area 12/47) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.76989 PKNOX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.1743 anterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.95359 Leukodystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.446 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M8-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nasopharynx TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 PMC8844187-Table_2.xlsx-prostate-DLX1_DLX1 Rummagene Transcription Factor Associations 2026 1.0 null KLK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85734 MFAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30664 3-O-Sulfogalactosylceramide (d18:1/12:0) HMDB Metabolites of Enzymes 1.0 null Prostate adenocarcinoma_PRAD_TCGA-2A-A8VL-01A-21R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of p1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.1096 EML4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3767 B4GALNT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96343 Gustatory areas, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21823 TRAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49006 GSE253041_1_v_0_ramp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Spermary TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.421 Sphingolipid metabolism KEGG Pathways 2026 1.0 null GLYCTK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8059 Claustrum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00134 Galabiosylceramide (d18:1/24:0) HMDB Metabolites of Enzymes 1.0 null GTEX-WZTO-0126-SM-3NM95 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20995 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20U-11A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LRCH4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26642 HCC2935 CCLE Cell Line Gene Expression Profiles -1.0 -1.65339 biosynthetic process GO Biological Process Annotations 2015 1.0 null 496100316_TCx_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.32415 orbital frontal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.67285 HNRNPUL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08154 lateral tuberal nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.35814 multiform (lateral) division of MD Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.51281 mediates GeneRIF Biological Term Annotations 1.0 null spleen HPA Tissue Protein Expression Profiles -1.0 -2.36012 ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ChIP_DMAP1_20946988 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTEX-WI4N-2726-SM-3LK7Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.07639 DYRK1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48869 MAT2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38198 anterior orbital gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.940862 sphingoid biosynthetic process GO Biological Process Annotations 2015 1.0 null BFTC909 CCLE Cell Line Gene CNV Profiles -1.0 -1.54343 regulation of primary metabolic process GO Biological Process Annotations 2015 1.0 null Perturb_661_KD_lncRNA_177417_SRP093784 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.92742 abnormal skin development MGI Mouse Phenotype Associations 2023 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-Q3-A5QY-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE199034_1_v_2_pirfenidone_mouse RummaGEO Drug Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-A75L-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KBTBD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49344 cellular developmental process GO Biological Process Annotations 2015 1.0 null GTEX-T5JW-0726-SM-4DM6D GTEx Tissue Sample Gene Expression Profiles 1.0 0.848882 Rectum adenocarcinoma_READ_TCGA-G5-6572-02A-12R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal sebocyte morphology MGI Mouse Phenotype Associations 2023 1.0 null posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03056 A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_7day-MOI-10^3_None_GSE44445 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.07683 ZBTB7B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.8573 NFKBIA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28047 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7062-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAP3K7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05967 REPIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09478 TMEM88 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76724 RNASE7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59858 GATA3 ENCODE Transcription Factor Targets 1.0 null RHBDD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29851 SNU1076 CCLE Cell Line Gene CNV Profiles -1.0 -1.63005 musculoskeletal system disease GWASdb SNP-Disease Associations 1.0 0.092164 GSE178255_1_v_4_tlr4_mouse RummaGEO Gene Perturbation Signatures 1.0 null Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.12151 dorsomedial preoptic area, superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56781 GSE239844_4_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null FEZF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91097 U-2 OS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.966702 Perturb_4794_Mut_Rnf12_SRP259110 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.3482 DB CCLE Cell Line Gene CNV Profiles 1.0 2.25109 organonitrogen compound catabolic process GO Biological Process Annotations 2015 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-77-7335-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.548 Autoimmune disease of skin and connective tissue DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.099 ZNF85 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.4298 RGP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83904 GTEX-POYW-1326-SM-48TCG GTEx Tissue Sample Gene Expression Profiles 1.0 0.989811 Pollen tube COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.541 LACC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79636 Puberty, Precocious CTD Gene-Disease Associations 1.0 1.34694 CAKI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15529 AICDA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88468 ZNF699 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45142 CiliaryGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.920063 GTEX-X4XY-0226-SM-4E3IZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.877636 GSE81193_0_v_4_irf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCI-H847 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14218 ACTR5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23993 FAM169A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18502 GSE148692,GSE148695_7_v_4_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-W5X1-2526-SM-3GILC GTEx Tissue Sample Gene Expression Profiles 1.0 1.38243 Cerebral degeneration DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.347 IFIT5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8973 abnormal retinal pigmentation MPO Gene-Phenotype Associations 1.0 null Fruit capsule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.947 SNU-182 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23136 Lung squamous cell carcinoma_LUSC_TCGA-56-7579-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Primary visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1491 GTEX-UJHI-1526-SM-3DB99 GTEx Tissue Sample Gene Expression Profiles 1.0 2.66862 DB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15529 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TV-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ARV1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17518 NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.966702 disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.029006 cellular response to inorganic substance GO Biological Process Annotations 2015 1.0 null PMC8500868-401_2021_2354_MOESM5_ESM.xlsx-GEP_PATZ1-Gene_Symbol_PATZ1 Rummagene Transcription Factor Associations 2026 1.0 null NDRG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03107 GTEX-R55F-0126-SM-48FCK GTEx Tissue Sample Gene Expression Profiles 1.0 0.902797 Perturb_17248_OE_Tnfsf15_SRP106312 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.67661 layer 1 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40217 liver HPA Tissue Protein Expression Profiles -1.0 -0.7012 GSE145215_0_v_3_krt13_mouse RummaGEO Gene Perturbation Signatures -1.0 null Serine C-palmitoyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.06 Cer(d18:1/14:0) HMDB Metabolites of Enzymes 1.0 null superficial stratum of r6BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12907 H3K27me3_megakaryocyte_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PDX1_KO_GDS4348_360_mouse_Proximal small intestine GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-O5YW-0126-SM-3LK6D GTEx Tissue Sample Gene Expression Profiles 1.0 1.99962 Zfp36l2_deficiency_GDS3574_153_mouse_E14.5 fetal liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null OCI-M1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15608 C170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.25121 cerebellar hemisphere Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04216 single-organism process GO Biological Process Annotations 2015 1.0 null PC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1925 HPAFII DepMap CRISPR Gene Dependency 1.0 3.6708 Gastrointestinal tract TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 ETF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68219 sphingoid biosynthetic process GO Biological Process Annotations 2025 1.0 null SP140 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46128 Autosomal recessive congenital ichthyosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.387 H3K27me3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 3-O-Sulfogalactosylceramide (d18:1/14:0) HMDB Metabolites of Enzymes 1.0 null SREBF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.8423 RAB7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56168 dorsal subdivision of VLC Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.89932 DES_KO_GDS4804_171_mouse_young skeletal muscles GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE206093,GSE206094_1_v_3_isl1_mouse RummaGEO Gene Perturbation Signatures -1.0 null NACC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56753 PrefrontalCortex BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.13796 tonsil HPA Tissue Protein Expression Profiles -1.0 -1.15253 ZHX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77541 GTEX-REY6-1326-SM-48FDO GTEx Tissue Sample Gene Expression Profiles 1.0 0.892282 GTEX-RWSA-0126-SM-2XCBB GTEx Tissue Sample Gene Expression Profiles 1.0 1.37944 IGR-37 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.857019 Trihexosylceramide (d18:1/24:0) HMDB Metabolites of Enzymes 1.0 null NCI-H1650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.02249 CDKN2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61137 sphingosine and sphingosine-1-phosphate metabolism HumanCyc Pathways 1.0 null TE8 DepMap CRISPR Gene Dependency 1.0 2.14808 PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Down_bins-Down_bins_loosing_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null TGIF2LY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75684 GTEX-WHSB-1326-SM-3LK6W GTEx Tissue Sample Gene Expression Profiles 1.0 2.02302 Urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 ZNF174 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53564 ZNF800 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92847 Perturb_4648_KO_Ppan_SRP349703 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.42767 gracile nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.856741 DHRS11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68864 intermediate stratum of JcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.558 ZNF157 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.8545 GSE254526,GSE254528_0_v_1_phf19_human RummaGEO Gene Perturbation Signatures -1.0 null Piriform area, polymorph layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07268 alcohol metabolic process GO Biological Process Annotations 2015 1.0 null KG1C CCLE Cell Line Gene Expression Profiles -1.0 -1.51679 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_62_KLF4 Rummagene Transcription Factor Associations 2026 1.0 null r10 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04952 lateral medullary reticular group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.5275 Silk gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.819 posteroventral (inferior) parietal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.67419 Adrenocortical carcinoma_ACC_TCGA-OR-A5J3-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NH12 DepMap CRISPR Gene Dependency 1.0 3.02326 GTEX-Q2AH-1626-SM-3GAF8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.50391 interpeduncular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02458 GSE124471,GSE124488_1_v_0_lats1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZBTB7A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.5244 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051084 HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30626 COMMD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87341 SLC25A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56868 Acute Myeloid Leukemia_LAML_TCGA-AB-2879-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null REC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.74894 18801183-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null Liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.33 sphingolipid biosynthetic process GO Biological Process Annotations 2015 1.0 null layer IIIb of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00517 GATA3_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRG1_DEPLETION_GDS2156_720_mouse_Embryos (maternally depleted) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null medial amygdala, posteroventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37093 KBTBD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23411 cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GTEX-WFG8-2226-SM-3GIL9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.1726 GSE94814_2_v_3_reck_mouse RummaGEO Gene Perturbation Signatures -1.0 null Brain - Cerebellar Hemisphere GTEx Tissue Gene Expression Profiles 2023 1.0 5.42638 AMIGO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07751 EN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81174 response to calcium ion GO Biological Process Annotations 2025 1.0 null SLC25A23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58921 VHL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70521 NOL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30134 DETROIT562 DepMap CRISPR Gene Dependency 1.0 6.30946 COR-L279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.855814 PMC5380038__SF2 PFOCR Pathway Figure Associations 2023 1.0 null Galactosylceramide (d18:1/24:1(15Z)) HMDB Metabolites of Enzymes 1.0 null PEMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72622 paracentral lobule, posterior part, right, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.96929 HCC1419 CCLE Cell Line Gene Expression Profiles 1.0 2.31431 GTEX-X4XX-0126-SM-3NMC2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.464 UGDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98975 Endoplasmic reticulum COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 CTCF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23693 GSE73381,GSE73382_0_v_1_hira_mouse RummaGEO Gene Perturbation Signatures 1.0 null CORL279 CCLE Cell Line Gene CNV Profiles 1.0 2.07633 sphingosine GeneRIF Biological Term Annotations 1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null XPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30082 PMC4155643__F1 PFOCR Pathway Figure Associations 2023 1.0 null GSE148252_1_v_6_npas4_mouse RummaGEO Gene Perturbation Signatures -1.0 null N-Acylsphingosine MW Enzyme Metabolite Associations 1.0 null Trihexosylceramide (d18:1/9Z-18:1) HMDB Metabolites of Enzymes 1.0 null skeletal muscle HPA Tissue Protein Expression Profiles -1.0 -2.36012 N-acylsphingosine amidohydrolase activity GO Molecular Function Annotations 2025 1.0 null Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.314 vagina GTEx Tissue Gene Expression Profiles 1.0 1.06351 GSE132694,GSE132717_0_v_2_meis1_human RummaGEO Gene Perturbation Signatures -1.0 null KM12 CCLE Cell Line Gene Expression Profiles -1.0 -1.64264 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7425-11A-01R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null liminal part of alar p1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.05869 GSE130081,GSE130082_5_v_1_neil2_mouse RummaGEO Gene Perturbation Signatures 1.0 null WRNIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02755 CBX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55518 Perturb_12224_KD_CASZ1_SRP267080 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.98441 GLUD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10469 Lung adenocarcinoma_LUAD_TCGA-55-7724-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTF2F1 ENCODE Transcription Factor Targets 1.0 null EPB41L5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91821 OCIMY7 CCLE Cell Line Gene CNV Profiles 1.0 1.41498 intermediate stratum of LPrP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23296 abnormality of male internal genitalia GWASdb SNP-Phenotype Associations 1.0 0.522707 OV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.92585 EVSA-T COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-OHPK-2526-SM-3MJH9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.859831 Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.761 Duodenum Mucosa Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.10404 NDEL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84851 ASCL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 59.6458 esophagus_5b HPA Tissue Sample Gene Expression Profiles 1.0 1.10588 GTEX-SSA3-0126-SM-32QPU GTEx Tissue Sample Gene Expression Profiles 1.0 1.01672 NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.824392 IGSF9B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97917 pontine raphe nucleus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.15718 Intercalated amygdalar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08445 PMC3339861__F3 PFOCR Pathway Figure Associations 2024 1.0 null CHST3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51241 bed nucleus of stria terminalis, lateral amygdaloid division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24342 integument phenotype MPO Gene-Phenotype Associations 1.0 null SIX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91708 ZNF536 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21859 mRNA_NIPBL_20720539 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Primary visual area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29738 Galabiosylceramide (d18:1/26:0) HMDB Metabolites of Enzymes 1.0 null GTEX-X88G-0126-SM-47JZ3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.86548 NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.997225 Uterine Carcinosarcoma_UCS_TCGA-N5-A4RJ-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RORC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.4745 GSE179031_0_v_2_foxp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null FAHD2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41127 NR1D2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.7677 NAGLU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24471 cellular biosynthetic process GO Biological Process Annotations 2015 1.0 null USP51 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.585 PPARG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.8929 DUSP1_KO_GDS1606_773_mouse_spleens GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null ERV3-1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34765 Foxl2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.091 ESYT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59523 ZNF326 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33991 SNU1077 CCLE Cell Line Gene CNV Profiles -1.0 -1.53303 Lactosylceramide (d18:1/22:0) HMDB Metabolites of Enzymes 1.0 null IGLON5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44853 HUT-78 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.509 DEL CCLE Cell Line Gene CNV Profiles -1.0 -1.37027 organelle GO Cellular Component Annotations 2015 1.0 null inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.374438 Tetrahexosylceramide (d18:1/16:0) HMDB Metabolites of Enzymes 1.0 null VIIAf Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.861229 RRP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32243 Arteriosclerosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.148 PRKAR2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20408 hsa-miR-4489 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 SLC6A8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62969 ZNF33B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01079 CHCHD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20336 MSTO211H DepMap CRISPR Gene Dependency 1.0 2.58539 PRM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66904 GTEX-W5WG-1626-SM-4LMKG GTEx Tissue Sample Gene Expression Profiles 1.0 0.96562 UBE2H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58068 mRNA_GATA3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null PK8 DepMap CRISPR Gene Dependency 1.0 2.44357 GTEX-OIZG-1026-SM-3LK5X GTEx Tissue Sample Gene Expression Profiles 1.0 0.952082 ELF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.6248 BEX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00846 GTEX-RM2N-0726-SM-48FD5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.829808 GSE155305_3_v_0_ifitm3_mouse RummaGEO Gene Perturbation Signatures -1.0 null blood TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055099 Intestinal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.186 GTEX-QLQ7-1626-SM-2S1R8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.13329 Myeloid leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.088 mammillary body, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.35077 medial ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.74048 TARBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57594 GTEX-WY7C-2326-SM-3NB2U GTEx Tissue Sample Gene Expression Profiles 1.0 1.25963 not applicable_Hypothermia_GSE54229_131_mouse_Embryonic fibroblas GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null HN CCLE Cell Line Gene CNV Profiles 1.0 1.41068 DYNC1LI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8316 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4642-01B-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TOLLIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.19026 DNAJC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37844 ZNFX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19589 small molecule metabolic process GO Biological Process Annotations 2015 1.0 null KLM1 CCLE Cell Line Gene CNV Profiles -1.0 -1.53426 diol biosynthetic process GO Biological Process Annotations 2015 1.0 null MAP3K1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04707 GTEX-V1D1-2026-SM-3GAF4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2062 PHETA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89823 PRDM13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38787 pontine nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.938335 Sarcoma_SARC_TCGA-DX-A6BA-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GRHL3_01_336 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.70778 intracellular membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null SG in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.46602 Autoimmune disease of the nervous system DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.041 Silique TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.952 Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5EA-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ESR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.0401 HMGB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11614 GTEX-U3ZN-2326-SM-3DB7W GTEx Tissue Sample Gene Expression Profiles 1.0 1.56031 Cer(d18:0/18:0) HMDB Metabolites of Enzymes 1.0 null SAOS2 CCLE Cell Line Gene Expression Profiles -1.0 -2.14428 Medial amygdalar nucleus, anteroventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47961 UBL7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5852 Pollen tube TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.487 Paramedian lobule, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37501 PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-SP1_SP1 Rummagene Transcription Factor Associations 2026 1.0 null HEY DepMap CRISPR Gene Dependency 1.0 6.0162 regulation of biological process GO Biological Process Annotations 2015 1.0 null pigmentation phenotype MPO Gene-Phenotype Associations 1.0 null dihydroceramidase activity GO Molecular Function Annotations 2015 1.0 null Kidney Chromophobe_KICH_TCGA-KO-8410-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE227698_2_v_4_g0s2_human RummaGEO Gene Perturbation Signatures 1.0 null SRD5A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0587 sphingosine metabolic process GO Biological Process Annotations 2025 1.0 null LRRC41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47236 Midgut secretion TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.394 Pyramus (VIII), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.67116 3-O-Sulfogalactosylceramide (d18:1/24:0) HMDB Metabolites of Enzymes 1.0 null A-431 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.42254 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5894-11A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ACADM_KO_GDS4546_512_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Atopic dermatitis 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.123 UBE2Q2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40836 Sarcoma_SARC_TCGA-QQ-A5VA-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE127790_9_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures -1.0 null LDLRAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54042 H3K27me3_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE243491_1_v_2_oxaliplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Lysosomal storage disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.876 ESR1-26153859-MCF-7-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null OST4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42239 PcPL part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14267 Lactosylceramide (d18:1/12:0) HMDB Metabolites of Enzymes 1.0 null Intracranial arterial disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.564 ATF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.007 1-alkyl-2-acetylglycerophosphocholine esterase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.795 amygdalo-striatal transition Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20161 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29G-06A-12R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MH1C1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.618 SNGM DepMap CRISPR Gene Dependency 1.0 2.37626 intracellular organelle LOCATE Curated Protein Localization Annotations 1.0 null ventral premammillary nucleus (migrated) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17005 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7103-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null frontal pole, left, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.23176 Sarcoma_SARC_TCGA-DX-A7EI-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DUSP1_KO_GDS1606_772_mouse_spleens GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-Q734-1926-SM-2I5EV GTEx Tissue Sample Gene Expression Profiles 1.0 1.02604 ZDHHC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98873 SPATS2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.29273 MANEA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62891 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RK-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hippocampus (hippocampal formation)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.944661 TMEM151A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26996 SPDEF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57663 endoplasmic reticulum membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.49549 CHTOP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24802 H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SOD2_KO_GDS1080_128_mouse_heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null SNU-407 COSMIC Cell Line Gene Mutation Profiles 1.0 null TMEM88_KD_GSE43805_682_human_hES cells differentiated along the cardiac lineage GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null REST-19997604-NEURONS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null PELP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90393 PMC6050292__F7 PFOCR Pathway Figure Associations 2023 1.0 null ZNF212 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75776 Cer(d18:1/23:0) HMDB Metabolites of Enzymes 1.0 null anatomical structure development GO Biological Process Annotations 2015 1.0 null posteroventral (inferior) parietal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.18644 MNX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72399 PPIA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11997 POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null sphingoid biosynthetic process GO Biological Process Annotations 2023 1.0 null TBX2-33478486-IMR90-HUMAN-LUNG ChEA Transcription Factor Targets 2022 1.0 null COV434 CCLE Cell Line Gene Expression Profiles 1.0 1.40441 SCAI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84631 bone inflammation disease GWASdb SNP-Disease Associations 1.0 0.299888 response to inorganic substance GO Biological Process Annotations 2015 1.0 null GTEX-R55C-0826-SM-48FCL GTEx Tissue Sample Gene Expression Profiles 1.0 0.918122 Sphingolipid de novo biosynthesis Reactome Pathways 2014 1.0 null dorsal cortical nucleus of inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47005 Perturb_10216_KO_Csnk1a1/Trp53_ERP021472 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.65048 PMC7304214-40170_2020_217_MOESM6_ESM.xlsx-Lipid_signaling_13_e_UP-Li_et_al_2018_GSE88752_Linking_prostate_cancer_cell_AR_heterogeneity_to_distinct_castration_and_enzalutamide_responses_AR Rummagene Transcription Factor Associations 2026 1.0 null regulation of lipid metabolic process GO Biological Process Annotations 2015 1.0 null MV-4-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12088 Acute Myeloid Leukemia_LAML_TCGA-AB-2985-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBCEL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85879 ID4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70678 membrane lipid metabolic process GO Biological Process Annotations 2023 1.0 null Reflex, Abnormal CTD Gene-Disease Associations 1.0 1.28027 Niemann-Pick disease type A DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.268 ZNF143 ENCODE Transcription Factor Targets 1.0 null GTEX-T5JC-0426-SM-32PLO GTEx Tissue Sample Gene Expression Profiles 1.0 1.19747 abnormal sphingomyelin level MGI Mouse Phenotype Associations 2023 1.0 null NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.911228 Cortical amygdalar area, anterior part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14338 GTEX-XPVG-2126-SM-4B667 GTEx Tissue Sample Gene Expression Profiles 1.0 1.52813 TUNAR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52221 GTEX-X4EO-2926-SM-4E3JH GTEx Tissue Sample Gene Expression Profiles 1.0 1.31522 basal reticular formation of p1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.77073 3-O-Sulfogalactosylceramide (d18:1/26:1(17Z)) HMDB Metabolites of Enzymes 1.0 null GTEX-P4QT-0126-SM-2I3FL GTEx Tissue Sample Gene Expression Profiles 1.0 2.82408 Lung adenocarcinoma_LUAD_TCGA-86-8585-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A901-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MEIOB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14226 peduncular nucleus of the stria medullaris Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14267 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NP-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-UPIC-1426-SM-4IHLQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.871359 GTEX-S7SF-1426-SM-4AT5A GTEx Tissue Sample Gene Expression Profiles 1.0 0.850584 CA12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9781 RAB3A_KO_GDS2482_705_mouse_Cortex GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null OVCAR433 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.824392 Autoimmune disease of central nervous system DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.064 CWF19L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06342 intermediate stratum of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10108 LAMA2_Deficiency_GDS1778_747_mouse_Diaphragm (from dystrophia muscularis -dy/dy- mouse model) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01932 FREM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45262 Tetrahexosylceramide (d18:1/22:0) HMDB Metabolites of Enzymes 1.0 null KMS34 CCLE Cell Line Gene Expression Profiles 1.0 1.73222 Variable age at onset electroclinical syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.17 SNU1214 CCLE Cell Line Gene CNV Profiles -1.0 -2.41826 ZFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07081 cuneiform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18134 cell differentiation GO Biological Process Annotations 2015 1.0 null Stat4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.1956 VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.10204 lower (caudal) rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09387 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6959-11A-01R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HIVEP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62972 Galactosylceramide (d18:1/14:0) HMDB Metabolites of Enzymes 1.0 null abnormal retinal layer morphology MPO Gene-Phenotype Associations 1.0 null SCAF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93853 EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null upregulation GeneRIF Biological Term Annotations 1.0 null OCI-LY-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15529 GTEX-VUSG-2326-SM-4KL1U GTEx Tissue Sample Gene Expression Profiles 1.0 1.19916 GTEX-T8EM-1026-SM-3DB7M GTEx Tissue Sample Gene Expression Profiles 1.0 1.54623 MYC ChEA Transcription Factor Targets 1.0 null GTEX-S341-1226-SM-4AD5S GTEx Tissue Sample Gene Expression Profiles 1.0 0.942699 Glucosylceramide (d18:1/9Z-18:1) HMDB Metabolites of Enzymes 1.0 null ZBTB26 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.3872 GSE113385_0_v_1_six1_mouse RummaGEO Gene Perturbation Signatures -1.0 null DNAJC30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84704 integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 Brain Lower Grade Glioma_LGG_TCGA-DU-6405-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Anteroventral preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41686 L363 CCLE Cell Line Gene CNV Profiles 1.0 1.36065 Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KC-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Tetrahexosylceramide (d18:1/26:0) HMDB Metabolites of Enzymes 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-21-1076-01A-01R-0692-07,TCGA-21-1076-01A-02R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF697 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25053 mantle zone of APal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4069 Prostate adenocarcinoma_PRAD_TCGA-HC-7742-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.834945 Bronchus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Lung squamous cell carcinoma_LUSC_TCGA-77-A5G3-01A-31R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XUJ4-1826-SM-4BOOU GTEx Tissue Sample Gene Expression Profiles 1.0 1.24901 Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WQ-01A-12R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ECC10 CCLE Cell Line Gene CNV Profiles 1.0 1.39493 hippocampus (hippocampal formation)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.907372 cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 DROSHA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90776 GTEX-OIZH-0126-SM-2HMIS GTEx Tissue Sample Gene Expression Profiles 1.0 2.5589 SNU-475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.904751 GTEX-S7SF-1626-SM-3K2AY GTEx Tissue Sample Gene Expression Profiles 1.0 1.29039 GSE152432_5_v_4_zrsr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Demyelinating disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.067 496100384_HIP_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.23246 496100566_FWM_no dementia_no TBI_82_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.07671 paraventricular nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.17899 SMIM13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12479 Sphingolipidosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.83 GTEX-T2IS-0126-SM-4DM6O GTEx Tissue Sample Gene Expression Profiles 1.0 1.50257 posterior orbital gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.888443 GTEX-XOTO-0126-SM-4B66N GTEx Tissue Sample Gene Expression Profiles 1.0 1.36709 NR1I2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.61598 Woronin body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.534 CHML CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37986 RAB3IP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03779 Acute Myeloid Leukemia_LAML_TCGA-AB-2885-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A3LQ-01A-21R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DHX40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22128 H3K27me3_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.058 Acute Myeloid Leukemia_LAML_TCGA-AB-2920-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PK59 CCLE Cell Line Gene CNV Profiles -1.0 -1.79304 Mannosyl-diinositol-phosphorylceramide HMDB Metabolites of Enzymes 1.0 null GSE165122_0_v_3_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null ZNF550 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28461 BCL2L13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17591 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null LYRM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.95925 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A550-01A-61R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null response to calcium ion GO Biological Process Annotations 2023 1.0 null QTRT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59371 periventricular stratum of JcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.35769 GSE211128_3_v_1_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null PDE6G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08147 MJ CCLE Cell Line Gene Expression Profiles 1.0 1.66469 endoplasmic reticulum GO Cellular Component Annotations 2015 1.0 null 3-O-Sulfogalactosylceramide (d18:1/18:0) HMDB Metabolites of Enzymes 1.0 null PRKCSH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78487 CD34+ BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.909865 Galactosylceramide (d18:1/26:1(17Z)) HMDB Metabolites of Enzymes 1.0 null NFATC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02719 urinary bladder HPA Tissue Protein Expression Profiles 1.0 1.48737 PMC6698381__F3 PFOCR Pathway Figure Associations 2023 1.0 null superficial stratum of InsCx (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.182 Interanteromedial nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13657 Pheochromocytoma and Paraganglioma_PCPG_TCGA-PR-A5PF-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CAV1_Deficiency_GDS3551_559_mouse_Hearts GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null MFNG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64608 CDKN2D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18954 prostate neoplasm GWASdb SNP-Phenotype Associations 1.0 0.522707 Colonic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.105 PHF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.96607 GTEX-S7PM-0126-SM-4AD6S GTEx Tissue Sample Gene Expression Profiles 1.0 1.13248 GSE149880_2_v_1_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null PLAGL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45673 CEP68 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78549 external granular (germinal) layer of lower rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.03426 liminal part of r4 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16202 all GWASdb SNP-Phenotype Associations 1.0 0.033442 Endoplasmic reticulum membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 LMX1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52934 CCDC88B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52977 a2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.536 layer IIIu of area 35r Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.915224 GTEX-XUW1-0426-SM-4BOOT GTEx Tissue Sample Gene Expression Profiles 1.0 1.38411 GPC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84227 TUBA1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92201 Spinal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.604 rectum HPA Tissue Protein Expression Profiles 1.0 1.48737 DDX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52068 liminal alar domain of m1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.40719 Lung squamous cell carcinoma_LUSC_TCGA-LA-A446-01A-21R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47316 IM9 DepMap CRISPR Gene Dependency 1.0 5.07267 intermediate stratum of AStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38652 KCTD19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10601 NUP188 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68355 Glucosylceramide (d18:1/24:0) HMDB Metabolites of Enzymes 1.0 null Cer(d18:0/18:1(11Z)) HMDB Metabolites of Enzymes 1.0 null GSE235234_2_v_3_corticosterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null CTCF_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUYS-0126-SM-47JWZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.27874 GSE230329_0_v_3_dextran_mouse RummaGEO Drug Perturbation Signatures -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MD-01A-12R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cer(d18:0/23:0) HMDB Metabolites of Enzymes 1.0 null MRPL10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32265 Brain Lower Grade Glioma_LGG_TCGA-P5-A5F0-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal hair cycle anagen phase MGI Mouse Phenotype Associations 2023 1.0 null H2BC14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29002 KNS-81-FD COSMIC Cell Line Gene Mutation Profiles 1.0 null YY1AP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11286 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A116-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A6WM-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sphingolipid metabolism Reactome Pathways 2014 1.0 null abnormal hair cycle MGI Mouse Phenotype Associations 2023 1.0 null medial amygdala, anteroventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45718 SKMEL24 DepMap CRISPR Gene Dependency 1.0 2.20901 Rectum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Tcof1_OE_GDS998_154_mouse_neuroblastoma N1E-115 cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Ceramide (d18:1/16:0) HMDB Metabolites of Enzymes 1.0 null ZNF608 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99953 NDUFS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38609 GTEX-X62O-0126-SM-4E3JN GTEx Tissue Sample Gene Expression Profiles 1.0 0.881641 marrow cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065576 HCC70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.924971 GSE186647,GSE217288_2_v_7_hnrnpc_human RummaGEO Gene Perturbation Signatures -1.0 null GSE133763_0_v_1_chd1_human RummaGEO Gene Perturbation Signatures 1.0 null Cer(d18:1/26:0) HMDB Metabolites of Enzymes 1.0 null Cer(d18:0/14:0) HMDB Metabolites of Enzymes 1.0 null Entorhinal area, lateral part, layer 2b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19861 G111 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.305 NCI-H740 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-OHPL-0126-SM-2HMJ7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.11344 Lung squamous cell carcinoma_LUSC_TCGA-77-8133-01A-12R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ichthyosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.575 IZ in rostral cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03218 GSE83145_1_v_0_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null SG in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.34411 organelle part GO Cellular Component Annotations 2015 1.0 null hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO Molecular Function Annotations 2023 1.0 null single-organism developmental process GO Biological Process Annotations 2015 1.0 null FOXI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41143 RAD18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.99636 ceramide metabolic process GO Biological Process Annotations 2023 1.0 null membrane LOCATE Predicted Protein Localization Annotations 1.0 null primary metabolic process GO Biological Process Annotations 2015 1.0 null endoplasmic reticulum COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 ZNF780A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01381 Endoplasmic reticulum palmitoyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.06 Peripheral nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.066 ZNF528 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.5763 Phytosphingosine HMDB Metabolites of Enzymes 1.0 null intracellular organelle GO Cellular Component Annotations 2015 1.0 null periventricular nucleus, preoptic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.21965 POLR2A ENCODE Transcription Factor Targets 1.0 null N-Palmitoylsphingosine HMDB Metabolites of Enzymes 1.0 null Embryonic structure TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 NEUROD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.8076 Globus pallidus, external segment Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30383 SPECC1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73963 CLPTM1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30391 AK6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90195 SMIM12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11463 RBPMS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8037 Lactosylceramide (d18:1/26:0) HMDB Metabolites of Enzymes 1.0 null GSE131903_0_v_2_abca12_human RummaGEO Gene Perturbation Signatures -1.0 null abnormal hair growth MPO Gene-Phenotype Associations 1.0 null CTNND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73377 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4992-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_9779_KD_Gas41_SRP110498 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.96493 STAT3_01_168 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59699 CP in rostral hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.4571 abnormal coat/ hair morphology MPO Gene-Phenotype Associations 1.0 null skin TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.212413 MYC-27129775-CHIP-SEQ-CORNEA-MOUSE ChEA Transcription Factor Targets 2022 1.0 null MRPL52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.06382 RAD23A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63294 VZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.835247 ENTPD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22295 DBR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92937 Ski complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.059 periventricular stratum of JcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05244 ARF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48558 Lung adenocarcinoma_LUAD_TCGA-67-3773-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ES8 DepMap CRISPR Gene Dependency 1.0 5.28743 DCAF12L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05593 SG in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.47419 Anteromedial visual area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61537 EZH2 ENCODE Transcription Factor Targets 1.0 null YAPC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16757 periventricular stratum of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02616 KLF4 ChEA Transcription Factor Targets 1.0 null temporal pole, left, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.16032 Perturb_665_KO_Myc_SRP093784 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.07584 HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05483 Perturb_3824_OE_Nrf2_SRP057556 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.51933 layer 2 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27842 Gustatory areas, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30383 sphingolipids GeneRIF Biological Term Annotations 1.0 null CFAP20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65209 SNG-M COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE203308_6_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null abnormal keratohyalin granule morphology MGI Mouse Phenotype Associations 2023 1.0 null stratum pyramidale of rostral CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.25949 Lung squamous cell carcinoma_LUSC_TCGA-63-7021-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TSE9-0126-SM-3DB83 GTEx Tissue Sample Gene Expression Profiles 1.0 1.27067 GTEX-U8XE-0226-SM-4E3J3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.03313 disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.060782 TIA1_KO_GSE54418_261_mouse_midbrain GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null MRPL37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52868 ventral part of PcP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.5372 posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.957176 GTEX-S341-0526-SM-4AD5U GTEx Tissue Sample Gene Expression Profiles 1.0 0.871281 SOD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67865 abnormal energy homeostasis MPO Gene-Phenotype Associations 1.0 null MEC-2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.765 H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null COX7C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16364 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7178-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Parkinson's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.011 H2AFZ ENCODE Transcription Factor Targets 1.0 null Organelle membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 single-organism cellular process GO Biological Process Annotations 2015 1.0 null GTEX-T2IS-0826-SM-4DM6L GTEx Tissue Sample Gene Expression Profiles 1.0 0.954038 RC-K8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.3116 Skin epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.052 GATAD2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84167 inferior olivary complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.46817 Pitcher TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.111 Lung adenocarcinoma_LUAD_TCGA-95-A4VK-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10794186-41598_2024_51947_MOESM16_ESM.xlsx-Supplementary_Table_14_Shared-Supplementary_Table_14_Shared_genes_between_Gong_et_al_clusters_and_SOX9-AS1_regulated_genes_SOX9 Rummagene Transcription Factor Associations 2026 1.0 null layer 2 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13334 SUM 229PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.984795 lateral ventricle HPA Tissue Protein Expression Profiles -1.0 -0.7012 cellular catabolic process GO Biological Process Annotations 2015 1.0 null BLOC1S6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91553 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6938-11A-01R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cnidoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.66 ZNF778 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91033 Tetrahexosylceramide (d18:1/26:1(17Z)) HMDB Metabolites of Enzymes 1.0 null RASA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.33124 U-2932 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.25458 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CH-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Galabiosylceramide (d18:1/26:1(17Z)) HMDB Metabolites of Enzymes 1.0 null periventricular stratum of PcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14267 cellular_component LOCATE Curated Protein Localization Annotations 1.0 null GTEX-XBEW-1326-SM-4AT63 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06181 Lung TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 3T3-Swiss albino cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.901 sphingolipid biosynthetic process GO Biological Process Annotations 2025 1.0 null hsa-miR-513c TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 RTN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48882 primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.58104 Entorhinal area, lateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50613 GTEX-VJYA-1126-SM-3GIJU GTEx Tissue Sample Gene Expression Profiles 1.0 1.23838 sphingosine metabolic process GO Biological Process Annotations 2023 1.0 null NPC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.31157 abnormal lipid level MGI Mouse Phenotype Associations 2023 1.0 null pancreas BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.883255 Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KC-11A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HW-8320-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Supramammillary nucleus, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13005 GTEX-PWN1-0126-SM-2I3FK GTEx Tissue Sample Gene Expression Profiles 1.0 2.18294 response to abiotic stimulus GO Biological Process Annotations 2015 1.0 null membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null GTEX-S4P3-1126-SM-4AD52 GTEx Tissue Sample Gene Expression Profiles 1.0 0.9752 epidermis development GO Biological Process Annotations 2023 1.0 null CES2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87037 SW1353 CCLE Cell Line Gene Expression Profiles -1.0 -2.08532 GSE148692,GSE148695_2_v_3_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Cer(d18:0/25:0) HMDB Metabolites of Enzymes 1.0 null H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Glucosylceramide HMDB Metabolites of Enzymes 1.0 null inferior frontal gyrus, orbital part, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02329 MED29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14503 layer 4 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20001 inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.43029 GTEX-NFK9-0226-SM-2HMKQ GTEx Tissue Sample Gene Expression Profiles 1.0 2.37707 hematopoietic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055525 H3K4me1_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UPK5-1226-SM-4IHL8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.832229 Central amygdalar nucleus, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.7089 lipid metabolic process GO Biological Process Annotations 2015 1.0 null Hnf1a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.8703 CDC14C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63896 response to alkaline pH GO Biological Process Annotations 2025 1.0 null Primary somatosensory area, trunk Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06511 ventrolateral prefrontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05449 TRMT9B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78002 membrane lipid metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-Q2AH-0826-SM-48TZN GTEx Tissue Sample Gene Expression Profiles 1.0 0.863736 NFIL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57125 outer CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.43409 ZNF382 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 59.2928 CNKSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13456 ZNF680 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.3847 Glucosylceramide (d18:1/26:0) HMDB Metabolites of Enzymes 1.0 null CD1D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64559 INHBE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72965 GSE121198,GSE129779_0_v_2_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null 496100495_FWM_no dementia_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.10585 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7051-11A-02R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VASH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.81614 intracellular part LOCATE Curated Protein Localization Annotations 1.0 null GTEX-XXEK-0326-SM-4BRVV GTEx Tissue Sample Gene Expression Profiles 1.0 0.895523 precommissural nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.83472 GTEX-X638-0126-SM-47JZ8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06444 cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.67084 GTEX-OOBK-0625-SM-3LK5P GTEx Tissue Sample Gene Expression Profiles 1.0 0.89724 m2 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.41674 Cer(d18:0/26:1(17Z)) HMDB Metabolites of Enzymes 1.0 null Stomach Smooth Muscle Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.38858 anteroventral periventricular preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15609 GTEX-PVOW-0126-SM-2XCFA GTEx Tissue Sample Gene Expression Profiles 1.0 1.27644 GSE210885_5_v_4_klf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null sphingolipid catabolic process GO Biological Process Annotations 2023 1.0 null IZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01956 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6936-11A-01R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal carbon dioxide production MPO Gene-Phenotype Associations 1.0 null ZNF417 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94846 TAC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21137 GM1 gangliosidosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.303 PCDHB14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9368 abnormal enzyme/coenzyme activity MGI Mouse Phenotype Associations 2023 1.0 null OCRL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23864 SUDHL10 CCLE Cell Line Gene Expression Profiles 1.0 1.8064 MT-CO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78704 Galabiosylceramide (d18:1/24:1(15Z)) HMDB Metabolites of Enzymes 1.0 null embryonic stem feeder layer BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.01068 intrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null cellular lipid metabolic process GO Biological Process Annotations 2015 1.0 null GSE135705_5_v_3_corticosterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null HCAEC cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.535 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AR-20517297-VCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null abnormal eye morphology MPO Gene-Phenotype Associations 1.0 null tissue development GO Biological Process Annotations 2015 1.0 null PMC8566473-41467_2021_26653_MOESM3_ESM.xlsx-SOX2_interacting_proteins-Gene_symbol_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-P4PQ-0626-SM-3NMCU GTEx Tissue Sample Gene Expression Profiles 1.0 0.923504 abnormal hair growth MGI Mouse Phenotype Associations 2023 1.0 null PRSS53 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96081 RAB13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.92351 DCLRE1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81953 Perturb_10446_KO_Etaa1_SRP107760 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.48779 Cerebrovascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.114 Prostate adenocarcinoma_PRAD_TCGA-HC-8256-01A-11R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-HB-A5W3-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-P44H-0226-SM-2XCEU GTEx Tissue Sample Gene Expression Profiles 1.0 1.02751 Inferior colliculus, dorsal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47005 BIN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1554 SDAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28705 abnormality of skeletal morphology GWASdb SNP-Phenotype Associations 1.0 0.072001 GHITM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49951 GTEX-PX3G-0126-SM-2I3EN GTEx Tissue Sample Gene Expression Profiles 1.0 1.86 OPM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.932161 Axenfeld-Rieger syndrome type 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.137 SP in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 3.34509 integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053939 DGKA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25489 Prostate adenocarcinoma_PRAD_TCGA-EJ-7321-11A-01R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.18336 DETROIT562 CCLE Cell Line Gene CNV Profiles 1.0 1.77818 Mesothelioma_MESO_TCGA-TS-A7PB-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S3XE-1726-SM-3K2AM GTEx Tissue Sample Gene Expression Profiles 1.0 1.64064 CTBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44154 GTEX-OXRK-0226-SM-3NB2G GTEx Tissue Sample Gene Expression Profiles 1.0 1.17583 GTEX-X4XY-1726-SM-46MVO GTEx Tissue Sample Gene Expression Profiles 1.0 0.930871 Brain Lower Grade Glioma_LGG_TCGA-TM-A7CA-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CASKIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.69487 occipital pole, left, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.30883 Pollen coat COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.867 Liver hepatocellular carcinoma_LIHC_TCGA-EP-A12J-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null hypoglossal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.25634 central nuclear group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.70832 TGBC1TKB DepMap CRISPR Gene Dependency 1.0 5.96701 Lipid storage disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.861 ZNF506 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4353 cochlear nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.846638 ODC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34512 GTEX-OIZI-1426-SM-3NB1T GTEx Tissue Sample Gene Expression Profiles 1.0 0.826957 LMO2-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC10967382__F5 PFOCR Pathway Figure Associations 2024 1.0 null 496100459_PCx_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.18755 GTEX-NFK9-1126-SM-3LK78 GTEx Tissue Sample Gene Expression Profiles 1.0 0.883388 thick dermal layer MGI Mouse Phenotype Associations 2023 1.0 null cellular lipid catabolic process GO Biological Process Annotations 2015 1.0 null C22orf15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7588 MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X5EB-1926-SM-4E3IW GTEx Tissue Sample Gene Expression Profiles 1.0 1.33811 Acquired metabolic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.391 GAS6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99003 GSE234340_1_v_2_muc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Paramedian lobule, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.64197 PROX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.0372 periventricular stratum of p1B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39682 Water HMDB Metabolites of Enzymes 1.0 null medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.53609 gracile nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.844416 Promyelocytic leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.514 muscle GTEx Tissue Gene Expression Profiles -1.0 -1.40568 abnormal retinal pigment epithelium morphology MPO Gene-Phenotype Associations 1.0 null GTEX-RNOR-0126-SM-2TF57 GTEx Tissue Sample Gene Expression Profiles 1.0 1.32689 Lactosylceramide (d18:1/18:0) HMDB Metabolites of Enzymes 1.0 null epidermal cell differentiation GO Biological Process Annotations 2023 1.0 null PMC9408832__F3 PFOCR Pathway Figure Associations 2024 1.0 null membrane lipid biosynthetic process GO Biological Process Annotations 2015 1.0 null rostral zona incerta Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19481 DMRT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83248 ACP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74467 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44N-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LRRC8B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45431 abnormal ocular fundus morphology MPO Gene-Phenotype Associations 1.0 null GSE149359_2_v_0_asap2_human RummaGEO Gene Perturbation Signatures 1.0 null ANKS6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.32524 HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.42254 SKNO1 DepMap CRISPR Gene Dependency 1.0 3.7967 GTEX-OXRL-0126-SM-2YUMP GTEx Tissue Sample Gene Expression Profiles 1.0 1.01677 mantle zone of ZIC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19481 vision/eye phenotype MPO Gene-Phenotype Associations 1.0 null TRAPPC14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12427 PMC8528285-pbio.3001085.s010.xlsx-Fig_S8E-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_KO_3T3_ONLY_2084_GENES_MNT Rummagene Transcription Factor Associations 2026 1.0 null superficial stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.84143 Entorhinal area, lateral part, layer 2a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30383 SPAG5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14423 weight loss MGI Mouse Phenotype Associations 2023 1.0 null NCOR-22424771-293T-HUMAN ChEA Transcription Factor Targets 2022 1.0 null FBXO34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85773 ammonium ion metabolic process GO Biological Process Annotations 2015 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5KU-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null arthritis GWASdb SNP-Disease Associations 1.0 0.332974 GSE148692,GSE148695_2_v_0_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Intracranial berry aneurysm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.892 Cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.371 GTEX-SUCS-1926-SM-32PM3 GTEx Tissue Sample Gene Expression Profiles 1.0 2.03313 AGA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20013 ZNF214 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00474 CDON CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58217 HCC1187 CCLE Cell Line Gene CNV Profiles 1.0 1.43938 GSE211286_4_v_5_tcf12_mouse RummaGEO Gene Perturbation Signatures 1.0 null FAM104A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47915 HCC70 CCLE Cell Line Gene CNV Profiles -1.0 -1.76432 polyol biosynthetic process GO Biological Process Annotations 2015 1.0 null organic substance biosynthetic process GO Biological Process Annotations 2015 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A69Q-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OV90 CCLE Cell Line Gene Expression Profiles -1.0 -2.44377 Galabiosylceramide (d18:1/16:0) HMDB Metabolites of Enzymes 1.0 null cytoplasmic part GO Cellular Component Annotations 2015 1.0 null KU812 CCLE Cell Line Gene Expression Profiles 1.0 1.40248 POMC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34934 medial part of r10B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27914 HDAC2 ENCODE Transcription Factor Targets 1.0 null mediodorsal nucleus of thalamus_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.955723 GTEX-TML8-1126-SM-4DXSS GTEx Tissue Sample Gene Expression Profiles 1.0 0.904081 ZIC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86119 SH3GLB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69872 WSB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42476 ANKS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9295 Hereditary sensory neuropathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.483 MAFA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.3513 outer CP in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.88628 MYORG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74921 cellular metabolic process GO Biological Process Annotations 2015 1.0 null PMC10746608-427_2023_709_MOESM5_ESM.xlsx-SOX2_partners-SOX2_known_protein_partners_according_to_BioGrid_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null GSE143692_0_v_1_trim8_human RummaGEO Gene Perturbation Signatures 1.0 null posterior part of anterior hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02741 orbital frontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.1876 cellular process GO Biological Process Annotations 2015 1.0 null Crus 2, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.53529 MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.824392 superficial stratum of r7BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25902 superficial stratum of LPrP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.81137 CGREF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92742 DMRT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79667 Brain - Hippocampus GTEx Tissue Gene Expression Profiles 2023 1.0 4.62643 alcohol biosynthetic process GO Biological Process Annotations 2015 1.0 null cellular response to salt GO Biological Process Annotations 2023 1.0 null SYT6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49345 JcPL part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05244 GTEX-OXRO-0126-SM-2YUN4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.03759 intracellular part GO Cellular Component Annotations 2015 1.0 null GTEX-WOFL-0126-SM-3MJG2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.16287 KLF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93218 SNU81 CCLE Cell Line Gene Expression Profiles -1.0 -1.68579 small molecule biosynthetic process GO Biological Process Annotations 2015 1.0 null GTEX-X8HC-0126-SM-4E3JW GTEx Tissue Sample Gene Expression Profiles 1.0 1.27876 interpositus (intermediate) nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.30017 Soleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.098 appendix HPA Tissue Protein Expression Profiles -1.0 -0.7012 TP63_01_200 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.60101 VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.30233 GSE121319_1_v_2_gprc5a_human RummaGEO Gene Perturbation Signatures 1.0 null epidermal cell differentiation GO Biological Process Annotations 2015 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8106-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SLC30A5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04316 mantle zone of LPrP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66175 GSE148692,GSE148695_7_v_3_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCO2 CCLE Cell Line Gene CNV Profiles 1.0 2.03982 DTX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20979 FAM20C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7491 erg_19359602_huvec_lof_human_gpl570_gds3557 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.011672 ZGPAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37265 Perturb_13195_KO_HDAC3_ERP127280 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.83146 cellular nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null Sandhoff disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.091 SHISA9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47705 RGPD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34455 GSE138818_1_v_0_nanog_mouse RummaGEO Gene Perturbation Signatures -1.0 null GLI3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.1049 organic hydroxy compound metabolic process GO Biological Process Annotations 2015 1.0 null KDF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0425 PIFO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66907 GTEX-U8T8-0126-SM-3DB94 GTEx Tissue Sample Gene Expression Profiles 1.0 1.22847 EGR1 ENCODE Transcription Factor Targets 1.0 null ceramide metabolic process GO Biological Process Annotations 2025 1.0 null Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.453 SAP30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91125 periventricular stratum of p1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.05869 ITLN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.363 RABL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74282 Brain Lower Grade Glioma_LGG_TCGA-HT-A4DS-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFIC::TLX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.875 METTL2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.50846 PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_1_DLX4 Rummagene Transcription Factor Associations 2026 1.0 null GPR27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66196 HOXB2::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.0315 SW1088 CCLE Cell Line Gene Expression Profiles -1.0 -1.51319 PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-d-Classification_of_camel_SON_basal_genes_-_enzymes_SON Rummagene Transcription Factor Associations 2026 1.0 null HLA-DOA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84828 GTEX-XXEK-1626-SM-4BRUZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.1735 GTEX-OXRN-0126-SM-48TDM GTEx Tissue Sample Gene Expression Profiles 1.0 1.19713 Arachidonic acid HMDB Metabolites of Enzymes 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A8I7-01A-21R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Piriform area, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1307 dry skin MGI Mouse Phenotype Associations 2023 1.0 null anterior pretectal nucleus, ventral core part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.83532 COLO677 CCLE Cell Line Gene Expression Profiles 1.0 1.52826 LASP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76543 Nucleus of the brachium of the inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42675 r9 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18892 TMEM181 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03732 GTEX-QCQG-1726-SM-3GIJ9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.435 MINK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61536 GTEX-WI4N-1026-SM-3LK7N GTEx Tissue Sample Gene Expression Profiles 1.0 1.41564 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3N6-01A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal hair follicle infundibulum morphology MGI Mouse Phenotype Associations 2023 1.0 null inner CP in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.09925 MNAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66475 endomembrane system COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Type 2 diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.504 RB1CC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86846 GRHPR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.64351 GTEX-TML8-1926-SM-32QOS GTEx Tissue Sample Gene Expression Profiles 1.0 1.93421 Lung adenocarcinoma_LUAD_TCGA-86-7701-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null XRCC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98288 abnormal ceramide level MGI Mouse Phenotype Associations 2023 1.0 null Gustatory areas, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56733 HS695T CCLE Cell Line Gene Expression Profiles -1.0 -1.46718 CANT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66341 ELK4-26923725-CHIP-SEQ-MESODERM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-X5EB-2226-SM-46MW4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.40448 Primary somatosensory area, trunk, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.80445 HT-29 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09315 H3K36me3_CD3 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null planum temporale, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.56821 GSE124471,GSE124488_2_v_3_lats1_mouse RummaGEO Gene Perturbation Signatures -1.0 null superficial stratum of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.14954 CCND1-20090754-RETINA-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-X4EP-0626-SM-3P621 GTEx Tissue Sample Gene Expression Profiles 1.0 1.24349 GTEX-WYJK-0526-SM-3NM8Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.04162 Hair follicle inner root sheath TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.706 HCC1187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.873255 PTGR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30306 mitochondria-associated endoplasmic reticulum membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.957 Pancreatic adenocarcinoma_PAAD_TCGA-FB-A4P5-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NUDT16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57288 TENT4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07044 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051222 PL45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.855814 anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.51694 GGA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13346 H3K27ac_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null intermediate stratum of CoPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25091 Large intestine cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.18 ES-I3 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.44176 GTEX-R55E-1326-SM-48FCR GTEx Tissue Sample Gene Expression Profiles 1.0 0.848994 18614019-TableS4d GeneSigDB Published Gene Signatures 1.0 null GTEX-SJXC-0126-SM-2XCFF GTEx Tissue Sample Gene Expression Profiles 1.0 1.3022 membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Sebocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.007 bone disease GWASdb SNP-Disease Associations 1.0 0.162979 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6955-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEP78 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74984 abnormal epidermis stratum granulosum morphology MGI Mouse Phenotype Associations 2023 1.0 null dihydroceramidase activity GO Molecular Function Annotations 2023 1.0 null Nutrition disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.399 GTEX-WRHU-2826-SM-3MJG8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.11635 OAW28 CCLE Cell Line Gene CNV Profiles -1.0 -1.78723 FOXA1 ENCODE Transcription Factor Targets 1.0 null LEF1-29337183-MESC-MOUSE-STEM ChEA Transcription Factor Targets 2022 1.0 null MAT1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71858 PLPPR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79447 SFXN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85499 GSE205070_1_v_5_mertk_mouse RummaGEO Gene Perturbation Signatures 1.0 null cortico-medial group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.13189 esophagus GTEx Tissue Gene Expression Profiles 1.0 0.928907 GTEX-OOBK-0126-SM-2YUND GTEx Tissue Sample Gene Expression Profiles 1.0 1.13532 Trihexosylceramide (d18:1/25:0) HMDB Metabolites of Enzymes 1.0 null GTEX-N7MT-1926-SM-3LK5N GTEx Tissue Sample Gene Expression Profiles 1.0 0.920185 Perturb_3797_KO_BRG1_SRP165661 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 ZBTB42 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23663 SLIRP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44164 IER3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59951 R3HCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27833 FGFR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0888 Prostate adenocarcinoma_PRAD_TCGA-HC-8259-11A-01R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H358 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35996 dorsolateral prefrontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.833821 increased apoptosis MGI Mouse Phenotype Associations 2023 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6384-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SFTPC_KO_GDS4876_476_mouse_Lung Type II cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null substantia nigra, pars reticulata, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.959717 RAB43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01214 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LB-11A-11R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LIF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97447 mantle zone of PcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.7089 TDRD12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8184 d17 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.414 RTCB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94591 RNASE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33372 Piriform area, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.76703 ERF::NHLH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 55.0638 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FS-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null laterodorsal part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.43813 GDI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65377 GSE101537_4_v_2_neurog3_mouse RummaGEO Gene Perturbation Signatures -1.0 null SFTPC_KO_GSE35989_48_mouse_lung (type II cells) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09315 intermediate stratum of m1B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28157 SLC17A9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45532 Galactosylceramide (d18:1/16:0) HMDB Metabolites of Enzymes 1.0 null Diffusing capacity of carbon monoxide GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.522185 PMC12178384-mmc4.xlsx-Sheet1-Supp_Table_2_Differential_expression_analysis_of_CIC-rearranged_sarcomas_vs_BCOR-rearranged_sarcomas_CIC Rummagene Transcription Factor Associations 2026 1.0 null NSD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65129 Palmitic acid HMDB Metabolites of Enzymes 1.0 null PMC7409333__F1 PFOCR Pathway Figure Associations 2024 1.0 null KATOIII CCLE Cell Line Gene CNV Profiles -1.0 -1.35798 MYC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Carbohydrate metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.534 Central amygdalar nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.58694 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null skin inflammation MGI Mouse Phenotype Associations 2023 1.0 null PDCD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32813 CCHCR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19446 HLA-A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.22705 GSE148200_3_v_5_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null ZNF561 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99818 RCOR3-21632747-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null superior occipital gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.902743 generating GeneRIF Biological Term Annotations 1.0 null ZNF689 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.1316 GSE143212_1_v_2_bleomycin_mouse RummaGEO Drug Perturbation Signatures 1.0 null EGR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16201 heart muscle HPA Tissue Protein Expression Profiles -1.0 -0.7012 EVX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94143 DIFI DepMap CRISPR Gene Dependency 1.0 2.86514 TSSK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98452 Microgametophyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.82 Pancreatic adenocarcinoma_PAAD_TCGA-IB-A5ST-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE165122_2_v_3_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Progressive myoclonus epilepsy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.178 Rectum adenocarcinoma_READ_TCGA-AG-3592-01A-02R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal hair cycle telogen phase MGI Mouse Phenotype Associations 2023 1.0 null cancer GWASdb SNP-Disease Associations 1.0 0.038878 mammalian phenotype MPO Gene-Phenotype Associations 1.0 null MFAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9641 posteroventral (inferior) parietal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.25101 anterior pretectal nucleus, ventral superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42675 DMS 79 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.932161 Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FP-01A-21R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null spinal trigeminal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.14705 mantle zone of m1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.40719 GSE169617_1_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null membrane region COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.007697 posterior orbital gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.20037 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09215 GTEX-R3RS-0126-SM-3GIJL GTEx Tissue Sample Gene Expression Profiles 1.0 1.45522 NR0B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40142 ZNF763 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91784 skin_5e HPA Tissue Sample Gene Expression Profiles 1.0 1.80817 lateral amygdaloid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15712 erythrocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.255234 abnormal epidermis stratum corneum morphology MGI Mouse Phenotype Associations 2023 1.0 null sphingolipid metabolic process GO Biological Process Annotations 2023 1.0 null UPMD1 DepMap CRISPR Gene Dependency 1.0 2.27969 pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Bach1::Mafk JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.3421 EZH2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hydrolase activity, hydrolyzing o-glycosyl compounds GO Molecular Function Annotations 2015 1.0 null RAB3GAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58578 Glucose metabolism disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.533 FAM83G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12199 IgY immunoglobulin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.062 NR2C2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.2278 striatum_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.46719 Metabolism Reactome Pathways 2024 1.0 null rheumatoid arthritis GWASdb SNP-Phenotype Associations 1.0 0.935608 reproductive organ cancer GWASdb SNP-Disease Associations 1.0 0.205737 abnormal extracutaneous pigmentation MPO Gene-Phenotype Associations 1.0 null SATB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.18576 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.17086 HOP-92 COSMIC Cell Line Gene Mutation Profiles 1.0 null HCC1143 CCLE Cell Line Gene Expression Profiles -1.0 -1.68893 Perturb_9599_KO_Csnk1a1_ERP003394 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 Tauopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.181 GTEX-SE5C-1226-SM-4BRWV GTEx Tissue Sample Gene Expression Profiles 1.0 0.844769 primary motor cortex (area M1, area 4)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.958907 Brain Lower Grade Glioma_LGG_TCGA-DU-5853-01A-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal blood homeostasis MPO Gene-Phenotype Associations 1.0 null MJ DepMap CRISPR Gene Dependency 1.0 2.02053 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.901 Leaf epidermis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.176 primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.972118 Cer(d18:1/24:1(15Z)) HMDB Metabolites of Enzymes 1.0 null posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.34142 GTEX-WY7C-2126-SM-3NB2R GTEx Tissue Sample Gene Expression Profiles 1.0 1.40968 posterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.41674 POU3F1-26484290-ESCSS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null SIX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.1852 Metabolic dysfunction-associated steatotic liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.215 SCGB3A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72848 basolateral amygdaloid nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17377 IV, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.4341 cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.70329 PAGE4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45006 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A299-01A-21R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary motor cortex (area M1, area 4)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.19664 MM160113 DepMap CRISPR Gene Dependency 1.0 2.36679 PAQR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31784 3-O-Sulfogalactosylceramide (d18:1/24:1(15Z)) HMDB Metabolites of Enzymes 1.0 null GTEX-QVUS-0626-SM-447CC GTEx Tissue Sample Gene Expression Profiles 1.0 0.860506 Cerebral arterial disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.565 TRAIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46739 intermediate stratum of ZIC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19481 endoplasmic reticulum part GO Cellular Component Annotations 2015 1.0 null Allergic contact dermatitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.333 NFATC2IP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62147 Multiple sclerosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.075 abnormal homeostasis MPO Gene-Phenotype Associations 1.0 null FBXL15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88016 Electroclinical syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.115 GSE124048,GSE124067_1_v_0_irf6_mouse RummaGEO Gene Perturbation Signatures -1.0 null skin_5f HPA Tissue Sample Gene Expression Profiles 1.0 1.77001 BCAT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39934 TEN DepMap CRISPR Gene Dependency 1.0 3.12755 PMC4155643__F1 PFOCR Pathway Figure Associations 2024 1.0 null Piriform area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33773 inferior olive, dorsal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.34731 response to metal ion GO Biological Process Annotations 2015 1.0 null GTEX-WXYG-2026-SM-4E3IY GTEx Tissue Sample Gene Expression Profiles 1.0 1.45438 TP53BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82255 abnormal piliary canal morphology MGI Mouse Phenotype Associations 2023 1.0 null GTEX-S95S-0426-SM-4B64I GTEx Tissue Sample Gene Expression Profiles 1.0 0.921331 IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.3677 L1CAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76891 PPARA::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.7976 Primary immunodeficiency disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.24 Sarcoma_SARC_TCGA-DX-A1KX-01A-22R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FAM110D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96818 cd8.Tcell BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.22122 GTEX-VJWN-0126-SM-3GIK7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06797 dorsal endopiriform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45071 Intine COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.938 MTA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.81866 vestibular nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.892773 Sphingolipid metabolism Reactome Pathways 2024 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4722-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC5795782-supp_gad.302646.117_Supplemental_Table_S1.xlsx-Table_S1_1-Supplemental_Table_S1_1_Genes_significantly_downregulated_by_ARID5B_knockdown_ARID5B Rummagene Transcription Factor Associations 2026 1.0 null H4C13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79487 primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.09486 GTEX-WHWD-1826-SM-3LK6I GTEx Tissue Sample Gene Expression Profiles 1.0 1.3886 TNNC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52374 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.78 SLC20A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23619 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A3CH-11A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null response to alkaline pH GO Biological Process Annotations 2023 1.0 null Keratinocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.755 KMS-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08295 Metabolic dysfunction-associated steatohepatitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.059 lateral subdivision of BNST Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.826299 GSE190864,GSE190907_1_v_0_cacybp_human RummaGEO Gene Perturbation Signatures -1.0 null ERRFI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33874 diol metabolic process GO Biological Process Annotations 2015 1.0 null Tetrahexosylceramide (d18:1/24:1(15Z)) HMDB Metabolites of Enzymes 1.0 null diol biosynthetic process GO Biological Process Annotations 2023 1.0 null LNZ308 CCLE Cell Line Gene Expression Profiles 1.0 1.42373 VCAP CCLE Cell Line Gene CNV Profiles -1.0 -1.34688 GPR162 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.96946 GTEX-S32W-2126-SM-2XCB1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20638 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RE-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NXT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45207 Inferior olivary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.22977 CEM-ADR5000 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.804 mediodorsal nucleus of thalamus_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.849738 GTEX-T6MO-0526-SM-4DM6R GTEx Tissue Sample Gene Expression Profiles 1.0 1.0094 esophagus_5c HPA Tissue Sample Gene Expression Profiles 1.0 1.28344 SPEF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80881 PROX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6782 FAM110A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85716 cytoplasmic part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-TFAP4_TFAP4 Rummagene Transcription Factor Associations 2026 1.0 null superficial stratum of r9BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18855 abnormal skin sebaceous gland morphology MGI Mouse Phenotype Associations 2023 1.0 null Primary somatosensory area, nose Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07876 C11orf86 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45681 Folium-tuber vermis (VII), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.90432 RKO CCLE Cell Line Gene Expression Profiles 1.0 2.03132 GTEX-XQ8I-0426-SM-4BOPO GTEx Tissue Sample Gene Expression Profiles 1.0 1.50661 prostate cancer GWASdb SNP-Phenotype Associations 1.0 0.522707 Lung squamous cell carcinoma_LUSC_TCGA-77-7139-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHMP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37451 GTEX-RU72-0926-SM-2TF6B GTEx Tissue Sample Gene Expression Profiles 1.0 1.42832 endometrium HPA Tissue Protein Expression Profiles 1.0 0.80854 myeloid progenitor cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065189 superficial stratum of cerebellar hemisphere Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12188 MYF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.6267 PMC9497187__F9 PFOCR Pathway Figure Associations 2024 1.0 null Integumentary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.533 Neurohypophysis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.133 CAV1_KO_GDS3551_366_mouse_mouse heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-51-4081-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Agranular insular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29121 biological regulation GO Biological Process Annotations 2015 1.0 null GTEX-WYJK-0126-SM-3NMAB GTEx Tissue Sample Gene Expression Profiles 1.0 2.23016 Acute Myeloid Leukemia_LAML_TCGA-AB-2820-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB7C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.3596 NCI-H929 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08295 Brain Lower Grade Glioma_LGG_TCGA-FG-A60J-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NB69 DepMap CRISPR Gene Dependency 1.0 5.41395 Glucosylceramide (d18:1/18:0) HMDB Metabolites of Enzymes 1.0 null SUB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43833 Psoriasis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.103 hsa-miR-4508 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 POFUT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1091 Arachidic acid HMDB Metabolites of Enzymes 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-3925-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8020666-pnas.2015855118.sd09.xlsx-LPS_4_human_DRSG_higherRes-Ensemble_gene_id_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null impaired skin barrier function MGI Mouse Phenotype Associations 2023 1.0 null GSE181959_1_v_2_dextran_mouse RummaGEO Drug Perturbation Signatures -1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HE-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.021 parathyroid gland HPA Tissue Protein Expression Profiles -1.0 -0.7012 jvm2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.887 internal globus pallidus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14204 MPC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03693 KIZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46488 MEG01 CCLE Cell Line Gene CNV Profiles 1.0 1.70195 GSE248501_1_v_0_mst1_mouse RummaGEO Gene Perturbation Signatures -1.0 null eed_20123906_mouse_embryonic_stem_cell_lof_mouse_gpl1261_gse19076 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.068978 homeostasis/metabolism phenotype MPO Gene-Phenotype Associations 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-H6-A45N-11A-12R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Glucosylceramide (d18:1/26:1(17Z)) HMDB Metabolites of Enzymes 1.0 null CAL78 DepMap CRISPR Gene Dependency 1.0 3.6504 Sphingolipid signaling pathway KEGG Pathways 2026 1.0 null UDSCC2 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-TMZS-0126-SM-3DB9Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.32698 HCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23136 H3K27me3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWN1-0626-SM-48TDT GTEx Tissue Sample Gene Expression Profiles 1.0 0.995042 Fabry disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.392 GTEX-U3ZM-1526-SM-3DB9D GTEx Tissue Sample Gene Expression Profiles 1.0 1.26086 Egg chorion COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.861 NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00323 HN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.41064 Lung adenocarcinoma_LUAD_TCGA-97-A4M5-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PGM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84771 GTEX-WEY5-0926-SM-4LMI4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.855565 GSE210885_5_v_6_klf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null Endocrine gland cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.05 METTL24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52162 GTEX-X585-1226-SM-46MW7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.943266 GTEX-VUSG-2526-SM-4KL1V GTEx Tissue Sample Gene Expression Profiles 1.0 1.32645 PC3 CCLE Cell Line Gene CNV Profiles 1.0 1.36451 outer CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.61232 MBD3L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05735 Supplemental somatosensory area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.39184 scaly skin MGI Mouse Phenotype Associations 2023 1.0 null catabolic process GO Biological Process Annotations 2015 1.0 null H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NFIC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.775 ATM_knockout_74_GSE23116 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.12283 MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.966702 ZNF154 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65156 HAGHL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48327 increased oxygen consumption MPO Gene-Phenotype Associations 1.0 null membrane lipid metabolic process GO Biological Process Annotations 2025 1.0 null Gaucher's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.833 ZNF844 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64766 inferior frontal gyrus, opercular part, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.73622 insular cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18234 prostate HPA Tissue Gene Expression Profiles 1.0 0.825052 abnormal hair follicle physiology MGI Mouse Phenotype Associations 2023 1.0 null GSE107505_0_v_2_nanog_mouse RummaGEO Gene Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7819-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 SLC25A34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84461 NFYB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.2173 KRT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87305 endoplasmic reticulum part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 increased energy expenditure MGI Mouse Phenotype Associations 2023 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3N5-01A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.293 male reproductive organ cancer GWASdb SNP-Disease Associations 1.0 0.357485 hyperactivity MGI Mouse Phenotype Associations 2023 1.0 null OELE CCLE Cell Line Gene Expression Profiles 1.0 1.41589 ANKRD13B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67755 Glucosylceramide (d18:1/22:0) HMDB Metabolites of Enzymes 1.0 null TNKS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53593 SVIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17533 Anxiety Disorders CTD Gene-Disease Associations 1.0 1.3414 sphingolipid biosynthetic process GO Biological Process Annotations 2023 1.0 null Hereditary sensory and autonomic neuropathy type 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.646 Brain Lower Grade Glioma_LGG_TCGA-DB-5274-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PKD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04834 TACSTD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77875 TRAM1L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14098 PRDM5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51693 GTEX-S95S-1226-SM-4GICG GTEx Tissue Sample Gene Expression Profiles 1.0 1.60622 epidermal cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.360409 ceramidase activity GO Molecular Function Annotations 2015 1.0 null primary motor cortex (area M1, area 4)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.51332 abnormal genital system morphology GWASdb SNP-Phenotype Associations 1.0 0.102333 hsa-miR-4756-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 CHMP2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5238 TGIF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.7909 Tetrahexosylceramide (d18:1/20:0) HMDB Metabolites of Enzymes 1.0 null ZNF648 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90654 POLR2F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98278 FMR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2158 ventrolateral part of alar p1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.1096 Mouth TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 MZ in retrosplenial cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.71549 Metabolism Reactome Pathways 2014 1.0 null Gangliosidosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.208 Alopecia DisGeNET Gene-Disease Associations 1.0 null dilated hair follicle infundibulum MGI Mouse Phenotype Associations 2023 1.0 null U266B1 CCLE Cell Line Gene CNV Profiles 1.0 1.8591 Brain Lower Grade Glioma_LGG_TCGA-TM-A7C3-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NJ-01A-22R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cer(d18:1/26:1(17Z)) HMDB Metabolites of Enzymes 1.0 null PHLDB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41594 KHM1B CCLE Cell Line Gene Expression Profiles 1.0 1.47319 VPS29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47563 abnormal retina morphology MPO Gene-Phenotype Associations 1.0 null NCIH2228 CCLE Cell Line Gene Expression Profiles -1.0 -3.13791 t70-white-adipose_consensus MoTrPAC Rat Endurance Exercise Training 1.0 1.81963 Head TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 UBE2G2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88604 nasopharynx HPA Tissue Protein Expression Profiles 1.0 1.48737 Coronary artery endothelial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.516 ADNP_Deficiency - NULL MUTATION_GDS2540_692_mouse_E9 embryos - Homozygous mutant GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-WXYG-2326-SM-4E3I6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.38594 motor nucleus of trigeminal nerve, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.3202 SUP-T1 COSMIC Cell Line Gene Mutation Profiles 1.0 null rheumatoid arthritis GWASdb SNP-Disease Associations 1.0 1.06777 periventricular stratum of PcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66092 SCC-25 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.6004 NCIH647 CCLE Cell Line Gene CNV Profiles -1.0 -1.35318 abnormality of the skeletal system GWASdb SNP-Phenotype Associations 1.0 0.064838 HUWE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06203 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7046-11A-01R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CDK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59776 HSOS1 DepMap CRISPR Gene Dependency 1.0 2.08691 superficial stratum of LAP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01487 THOC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00538 intermediate portion of DFC (area 9/46) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.0596 mainolfactoryepithelium.MOE. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.60357 L-363 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.5918 H3K27me3_Skeletal Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Hepatobiliary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.1 enlarged sebaceous gland MGI Mouse Phenotype Associations 2023 1.0 null rhombomere 11 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1979 anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.20906 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OHPM-0126-SM-2YUN9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.5054 Brain Lower Grade Glioma_LGG_TCGA-TQ-A8XE-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26619 layer 3 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07683 Crus 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44219 Trihexosylceramide (d18:1/18:0) HMDB Metabolites of Enzymes 1.0 null disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039984 Heptadecanoyl CoA HMDB Metabolites of Enzymes 1.0 null placenta HPA Tissue Protein Expression Profiles 1.0 0.910504 LB1047RCC DepMap CRISPR Gene Dependency 1.0 2.3345 Prostate adenocarcinoma_PRAD_TCGA-EJ-7789-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RU72-0726-SM-46MUW GTEx Tissue Sample Gene Expression Profiles 1.0 0.830722 mantle zone of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28066 GSE178255_1_v_6_tlr4_mouse RummaGEO Gene Perturbation Signatures 1.0 null SW684 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-PWCY-1726-SM-48TD3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.918996 lateral hypothalamic area, tuberal part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05167 RAP2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8752 GTEX-WQUQ-0426-SM-3MJFU GTEx Tissue Sample Gene Expression Profiles 1.0 1.89548 Bed nucleus of the accessory olfactory tract Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07781 ITGA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12587 TFEC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5687 HCT15 DepMap CRISPR Gene Dependency 1.0 4.93256 CASC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99138 skin GTEx Tissue Gene Expression Profiles 1.0 2.18825 GTEX-W5WG-1826-SM-4KL2Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.25802 intermediate stratum of m2AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18134 P68-20966046-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null PLSCR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32771 ELF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.244 mantle zone of m2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53133 GTEX-R55E-0126-SM-2TC5Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.06663 Pharynx TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 single-organism catabolic process GO Biological Process Annotations 2015 1.0 null GTEX-QEG5-0226-SM-2I5GI GTEx Tissue Sample Gene Expression Profiles 1.0 0.97881 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7183-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventral part of JcP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.88603 H3K4me1_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null III, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.48642 Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SP-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HES4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66291 PMC6050292__F7 PFOCR Pathway Figure Associations 2024 1.0 null PLCG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11083 GTEX-RN64-0126-SM-2TC68 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01243 decreased circulating glucose level MPO Gene-Phenotype Associations 1.0 null Sporangiophore TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.017 MTRR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6867 GSE160083,GSE160084_1_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null TRIM35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32561 SUMF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74356 HCC1171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.924971 MOLT16 CCLE Cell Line Gene Expression Profiles 1.0 1.45044 GTEX-XQ3S-1526-SM-4BOOC GTEx Tissue Sample Gene Expression Profiles 1.0 1.29322 Organism form TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 biological_process GO Biological Process Annotations 2015 1.0 null GSE133070_2_v_4_prss1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5882-11A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null XRCC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12926 Crus 2, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31888 Perturb_5135_KO_Ythdc1_SRP251747 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.29301 SLC7A6OS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1276 outer SZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.836084 GTEX-X4EO-0326-SM-3P5YO GTEx Tissue Sample Gene Expression Profiles 1.0 1.39296 Colon cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.118 ZSWIM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57121 Synergid cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.887 AR-20517297-VCAP-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Primary somatosensory area, mouth, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12024 GSE243491_1_v_0_oxaliplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.885208 RCOR3-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null BCL6-25482012-CML-JURL-MK1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null KMM1 CCLE Cell Line Gene Expression Profiles 1.0 1.59897 FGF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17104 HL-60 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.231 m1Lim (VL) part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.91531 Eye-adipocyte Tabula Sapiens Gene-Cell Associations 1.0 0.992456 PNMA6F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66796 Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-7774-01A-21R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PROX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56769 GTEX-RWS6-0826-SM-47JXF GTEx Tissue Sample Gene Expression Profiles 1.0 0.907143 ZNF586 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13583 choroid plexus of the fourth ventricle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.936647 H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PKNOX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.3665 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.65365 H3K27me3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LIM1215 COSMIC Cell Line Gene Mutation Profiles 1.0 null MTF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61078 Acute Myeloid Leukemia_LAML_TCGA-AB-2854-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF75D JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.2291 GTEX-UPJH-0226-SM-3GADV GTEx Tissue Sample Gene Expression Profiles 1.0 1.67492 PPDPF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03801 SEPTIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51326 GTEX-TML8-1526-SM-4DXUX GTEx Tissue Sample Gene Expression Profiles 1.0 0.93697 PWWP2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7444 GTEX-RVPV-0526-SM-47JYL GTEx Tissue Sample Gene Expression Profiles 1.0 0.906666 Vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.37 Ectexine COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.037 NDOR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70715 paracentral lobule, posterior part, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.902401 18614019-TableS4c GeneSigDB Published Gene Signatures 1.0 null PANC0213 CCLE Cell Line Gene Expression Profiles -1.0 -1.94388 mantle zone of r4Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16202 CBX8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33491 NEURL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87683 decreased brown adipose tissue mass MGI Mouse Phenotype Associations 2023 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A65E-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VZ in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.69387 PECAPJ49 CCLE Cell Line Gene Expression Profiles -1.0 -2.37668 TMEM25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28275 periventricular stratum of m1B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04738 PAOX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16438 FOSB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99949 periventricular stratum of r1Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00805 increased eosinophil cell number MGI Mouse Phenotype Associations 2023 1.0 null Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.44 NIFK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12525 ZNF354C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35692 PMC7145850__F3 PFOCR Pathway Figure Associations 2023 1.0 null Ceramide (d18:1/22:0) HMDB Metabolites of Enzymes 1.0 null ASPRV1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52734 GTEX-XBED-1926-SM-47JYP GTEx Tissue Sample Gene Expression Profiles 1.0 1.18539 GTEX-S7SE-0126-SM-2XCD5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.37504 periventricular stratum of APal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23635 cell part GO Cellular Component Annotations 2015 1.0 null Gfi1b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.2981 ME1 CCLE Cell Line Gene Expression Profiles 1.0 1.8587 496100656_HIP_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.14148 CYB5R3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38376 GTEX-XV7Q-2526-SM-4BRV9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.18045 GSE74528_0_v_1_trex2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CMBL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41909 PSEN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42544 CABIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01379 Primary somatosensory area, lower limb, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.62244 Pyramus (VIII) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51488 prosomere 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03741 GTEX-WYVS-2126-SM-3NMA3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.65209 GSE179138_4_v_1_lama4_mouse RummaGEO Gene Perturbation Signatures -1.0 null ceramide metabolic process GO Biological Process Annotations 2015 1.0 null SW837 CCLE Cell Line Gene CNV Profiles -1.0 -1.5694 Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CG-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 superficial stratum of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20161 Dorsal premammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00281 ELF1 ChEA Transcription Factor Targets 1.0 null metabolic process GO Biological Process Annotations 2015 1.0 null ZNF362 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46028 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45O-01A-21R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Stoma TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.86 HOXD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57247 primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.33561 GTEX-U412-0426-SM-3DB9O GTEx Tissue Sample Gene Expression Profiles 1.0 2.07442 abnormal hair follicle morphology MGI Mouse Phenotype Associations 2023 1.0 null RBM26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54489 Ansiform lobule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14737 Inositol-P-ceramide HMDB Metabolites of Enzymes 1.0 null cellular response to oxygen-containing compound GO Biological Process Annotations 2023 1.0 null VZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.12504 KMS-11/TKO cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.702 amygdaloid complex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.849738 GSE158502,GSE158506_3_v_0_fat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null cerebellum BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.968883 NUDCD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17696 Acute Myeloid Leukemia_LAML_TCGA-AB-2964-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PWN1-2526-SM-48TDS GTEx Tissue Sample Gene Expression Profiles 1.0 0.97103 IER5L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73072 GSE118077_7_v_2_sprr5_human RummaGEO Gene Perturbation Signatures 1.0 null C18orf54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51912 TTLL13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42308 AQP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23185 NKX2-8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79801 arrest GeneRIF Biological Term Annotations 1.0 null inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.54543 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4114-01A-01R-1193-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal glucose homeostasis MPO Gene-Phenotype Associations 1.0 null Sarcoma_SARC_TCGA-UE-A6QT-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15415 496100419_TCx_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.95645 pontobulbar body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.11187 Lung squamous cell carcinoma_LUSC_TCGA-43-3394-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF784 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.0351 GSE188870,GSE188871_0_v_5_kat7_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC8534120__F2 PFOCR Pathway Figure Associations 2024 1.0 null Sphinganine HMDB Metabolites of Enzymes 1.0 null Cer(d18:1/22:1(13Z)) HMDB Metabolites of Enzymes 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-4605-01A-21R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBRG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47612 PMC11392820-41556_2024_1475_MOESM3_ESM.xlsx-Supplementary_Table_9-Supplementary_Table_9_Expression_level_of_OTX2_targeted_genes_n_999_related_to_Figure_6_OTX2 Rummagene Transcription Factor Associations 2026 1.0 null epidermal hyperplasia MGI Mouse Phenotype Associations 2023 1.0 null membrane region GO Cellular Component Annotations 2015 1.0 null RO60 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66146 mantle zone of JcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.88603 EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09315 N-Lignoceroylsphingosine HMDB Metabolites of Enzymes 1.0 null Tetrahexosylceramide (d18:1/9Z-18:1) HMDB Metabolites of Enzymes 1.0 null Galabiosylceramide (d18:1/18:0) HMDB Metabolites of Enzymes 1.0 null ZNF41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99376 abnormal eye pigment epithelium morphology MPO Gene-Phenotype Associations 1.0 null PLBD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27447 Autoimmune disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.251 Bronchoalveolar system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 TMEM54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7054 Prostate adenocarcinoma_PRAD_TCGA-G9-6367-01A-11R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null sphingolipid metabolic process GO Biological Process Annotations 2015 1.0 null TSEN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22166 GSE186647,GSE217288_2_v_4_hnrnpc_human RummaGEO Gene Perturbation Signatures -1.0 null ARHGAP19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82534 GSE121009,GSE121014_0_v_1_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null skin development GO Biological Process Annotations 2025 1.0 null GTEX-SNMC-0526-SM-4DM69 GTEx Tissue Sample Gene Expression Profiles 1.0 0.872426 Micropyle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.895 3-O-Sulfogalactosylceramide (d18:1/22:0) HMDB Metabolites of Enzymes 1.0 null t61-colon_consensus MoTrPAC Rat Endurance Exercise Training 1.0 3.67272 TRAPPC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34575 PMC10214295-mmc4.xlsx-B_-_Beta_Cell_ZBTB16_targets-Ensembl_Gene_ID_ZBTB16 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WH7G-0926-SM-4LVMJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.896259 abnormal gas homeostasis MPO Gene-Phenotype Associations 1.0 null NEUROG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44755 RAB3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89972 HNRNPAB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.35582 nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null TMEM88B_KD_GPL10558_471_human_cardiovascular progenitors cells differentiated from hES cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Perturb_13194_KO_Dax1_ERP127280 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.62287 VZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14265 r9 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.3339 TMEM18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17187 DEL CCLE Cell Line Gene Expression Profiles 1.0 1.65463 organic hydroxy compound biosynthetic process GO Biological Process Annotations 2015 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5890-11A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Corneocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.414 abnormal internal genitalia GWASdb SNP-Phenotype Associations 1.0 0.146473 HUO-3N1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.748 GLRX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87308 SOX11_DEPLETION_GDS4801_326_human_Z138 mantle cell lymphoma (MCL) cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Primary visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15541 dorsolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.52532 CENPS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73286 COL4A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48606 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81J-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE149769_1_v_0_nlrp12_mouse RummaGEO Gene Perturbation Signatures -1.0 null epidermal cell differentiation GO Biological Process Annotations 2025 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-8668-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null connective tissue disease GWASdb SNP-Disease Associations 1.0 0.128262 PAX2 JASPAR Predicted Transcription Factor Targets 1.0 null decreased brown fat cell lipid droplet size MGI Mouse Phenotype Associations 2023 1.0 null posteroventral (inferior) parietal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.961506 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3HV-01A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.95296 layer 2 of LPrP cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.99467 layer 1 of LOT Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03263 anterior (rostral) cingulate (medial prefrontal) cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.25899 MAP2K4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69408 cellular response to calcium ion GO Biological Process Annotations 2025 1.0 null GTEX-X62O-2226-SM-46MW3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.824417 sparse hair MPO Gene-Phenotype Associations 1.0 null KLM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.34522 Brain Lower Grade Glioma_LGG_TCGA-VW-A8FI-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE149880_0_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null VDR-20736230-LYMPHOBLASTOID-HUMAN ChEA Transcription Factor Targets 2022 1.0 null RORA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.5389 CAKI2 CCLE Cell Line Gene CNV Profiles -1.0 -1.37569 NTS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79227 H3K4me1_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null DTX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02021 NOA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25159 endoplasmic reticulum LOCATE Curated Protein Localization Annotations 1.0 null Synucleinopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.007 Golgi lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.961 RRBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98689 catalytic activity GO Molecular Function Annotations 2015 1.0 null cellular response to calcium ion GO Biological Process Annotations 2023 1.0 null MZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1759 Ceramide (d18:1/12:0) HMDB Metabolites of Enzymes 1.0 null ceramide catabolic process GO Biological Process Annotations 2025 1.0 null Urogenital Abnormalities CTD Gene-Disease Associations 1.0 1.12117 NXPE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30472 GTEX-XAJ8-1426-SM-47JYM GTEx Tissue Sample Gene Expression Profiles 1.0 1.44975 lateropallial prepiriform area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66224 Galabiosylceramide (d18:1/25:0) HMDB Metabolites of Enzymes 1.0 null RHBDD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52346 SCRT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.531 TDOTT DepMap CRISPR Gene Dependency 1.0 2.28944 paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1648 PcPV part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66092 CALU6 DepMap CRISPR Gene Dependency 1.0 2.55993 RAB3IL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08385 CLCN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44025 Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-A5NJ-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar white matter Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02585 Intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 ZNF317 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.9761 rostral ventrolateral reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25941 decreased epididymal fat pad weight MGI Mouse Phenotype Associations 2023 1.0 null Krabbe disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.625 HDAC2_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLAIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58844 RMG-I COSMIC Cell Line Gene Mutation Profiles 1.0 null sphingolipid metabolic process GO Biological Process Annotations 2025 1.0 null GSE127790_5_v_3_zcchc8_mouse RummaGEO Gene Perturbation Signatures -1.0 null IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08105 Central amygdalar nucleus, capsular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62941 Sarcoma_SARC_TCGA-SI-A71O-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary auditory cortex (core)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.02778 SH3PXD2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2961 NCIH520 CCLE Cell Line Gene CNV Profiles 1.0 1.33965 RERFLCSQ1 CCLE Cell Line Gene Expression Profiles -1.0 -1.66646 Nephrotic syndrome type 14 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.332 caudal ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.74846 RPMI7951 DepMap CRISPR Gene Dependency 1.0 2.72829 Hematologic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.217 GTEX-U3ZN-1626-SM-4DXTZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.945358 polymorphic layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.44892 GSE240258_0_v_1_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SNAI3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.6874 cellular response to stimulus GO Biological Process Annotations 2015 1.0 null U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.07215 r5 part of posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1111 Prostate adenocarcinoma_PRAD_TCGA-VN-A88N-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cer(d18:0/24:1(15Z)) HMDB Metabolites of Enzymes 1.0 null Ceramide (d18:1/18:0) HMDB Metabolites of Enzymes 1.0 null GTEX-RN64-1026-SM-48FDX GTEx Tissue Sample Gene Expression Profiles 1.0 0.960823 plasma membrane LOCATE Predicted Protein Localization Annotations 1.0 null jvm3 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.51 Cer(d18:0/26:0) HMDB Metabolites of Enzymes 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-5319-01A-01R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QDT8-0126-SM-48TZ1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01522 FHOD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43509 YJU2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65728 inner SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.873511 EP300 ENCODE Transcription Factor Targets 1.0 null intracellular organelle part GO Cellular Component Annotations 2015 1.0 null keratinocyte differentiation GO Biological Process Annotations 2025 1.0 null Colorectal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.181 721_B_lymphoblasts BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.890021 SMUG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68887 ELOA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61931 response to alkaline ph GO Biological Process Annotations 2015 1.0 null increased keratinocyte proliferation MGI Mouse Phenotype Associations 2023 1.0 null DNASE1L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33262 GTEX-V1D1-2226-SM-3NMAX GTEx Tissue Sample Gene Expression Profiles 1.0 1.0051 SPG11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73123 KMS27 CCLE Cell Line Gene CNV Profiles 1.0 1.65786 Glucosylceramide (d18:1/16:0) HMDB Metabolites of Enzymes 1.0 null superior parietal lobule, left, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.937353 GSE169152_5_v_2_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null ZNF99 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70835 Hair follicle bulge stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.181 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7059-11A-01R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF ENCODE Transcription Factor Targets 1.0 null Trihexosylceramide (d18:1/12:0) HMDB Metabolites of Enzymes 1.0 null Skin disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.472 supraoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.28252 3-O-Sulfogalactosylceramide (d18:1/16:0) HMDB Metabolites of Enzymes 1.0 null abnormal awl hair morphology MGI Mouse Phenotype Associations 2023 1.0 null GSE133213_11_v_3_znrf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null normoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.164091 decreased sphingosine level MGI Mouse Phenotype Associations 2023 1.0 null GSE145215_2_v_3_krt13_mouse RummaGEO Gene Perturbation Signatures 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2999-03B-01T-0748-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ABCB10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6962 Tridecanoic acid HMDB Metabolites of Enzymes 1.0 null PELI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72011 Sepsis_Splenocyte_GSE4479 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.77341 increased basal metabolism MGI Mouse Phenotype Associations 2023 1.0 null Rectum adenocarcinoma_READ_TCGA-G5-6235-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Galabiosylceramide (d18:1/9Z-18:1) HMDB Metabolites of Enzymes 1.0 null USP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62768 THNSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32999 GLB1L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88995 RINT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90885 NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.904751 USF2 JASPAR Predicted Transcription Factor Targets 1.0 null hydrolase activity, acting on glycosyl bonds GO Molecular Function Annotations 2015 1.0 null organic substance metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-NPJ8-0126-SM-2YUNR GTEx Tissue Sample Gene Expression Profiles 1.0 1.26354 subpretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06285 ott1_22490678_hematopoietic_stem_cell_lof_mouse_gpl8321_gds4315 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.052848 JHESOAD1 DepMap CRISPR Gene Dependency 1.0 2.39599 TSPAN13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56498 GTEX-QLQW-1126-SM-2S1Q8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12673 GTEX-PW2O-1426-SM-48TCD GTEx Tissue Sample Gene Expression Profiles 1.0 0.857896 HS172T CCLE Cell Line Gene Expression Profiles -1.0 -1.86734 IZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.854218 HSFX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07638 MS751 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.48308 SKNEP1 DepMap CRISPR Gene Dependency 1.0 2.13711 TMEM11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61246 hsa-miR-514b-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 CHMP1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95993 organonitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null Tcf12 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.4936 abnormal circulating glucose level MPO Gene-Phenotype Associations 1.0 null abnormal energy expenditure MPO Gene-Phenotype Associations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6229-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null epidermis development GO Biological Process Annotations 2025 1.0 null ceramide catabolic process GO Biological Process Annotations 2015 1.0 null Paraflocculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36889 GTEX-XK95-0226-SM-4AT58 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00182 increased energy expenditure MPO Gene-Phenotype Associations 1.0 null NCI-H920 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.847348 MSH4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73552 GTEX-OXRN-1726-SM-3NM9B GTEx Tissue Sample Gene Expression Profiles 1.0 0.918024 Sebum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.249 cingulate gyrus, parietal part, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.829693 FLOT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.06219 RNF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.81902 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A116-11A-12R-A26B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RELB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61542 Dermatitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.33 HAND2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.6656 TGIF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.917 GTEX-WYVS-1626-SM-3NM9R GTEx Tissue Sample Gene Expression Profiles 1.0 1.25966 dorsal cochlear nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.926245 hydrolase activity GO Molecular Function Annotations 2015 1.0 null GSE137702_2_v_1_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null GSE148695,GSE167284_2_v_1_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null 496100372_HIP_dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.46665 PTGR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03855 PCI30 DepMap CRISPR Gene Dependency 1.0 2.55666 sphingosine biosynthetic process GO Biological Process Annotations 2025 1.0 null skin HPA Tissue Gene Expression Profiles 1.0 1.81726 Lung squamous cell carcinoma_LUSC_TCGA-56-8624-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Organelle subcompartment COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 dorsal motor nucleus of the vagus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.888651 H3K27me3_megakaryocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kasumi-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.564 dorsal thalamus_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09991 bronchus HPA Tissue Protein Expression Profiles 1.0 1.48737 RMI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28648 inferior occipital gyrus, left, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.11127 GTEX-TKQ1-1026-SM-4GICL GTEx Tissue Sample Gene Expression Profiles 1.0 1.54963 KATO III Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.6004 Lung squamous cell carcinoma_LUSC_TCGA-J1-A4AH-01A-31R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE183994_3_v_0_scml2_mouse RummaGEO Gene Perturbation Signatures -1.0 null NAT8L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.15626 L3MBTL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72269 cell part LOCATE Curated Protein Localization Annotations 1.0 null MTRES1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07783 inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.35952 RPL36A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96495 Lung adenocarcinoma_LUAD_TCGA-55-7725-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mesomere 2 (preisthmus or caudal midbrain) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2893 REC1 CCLE Cell Line Gene CNV Profiles 1.0 1.88128 GSE154577_6_v_10_plagl1_human RummaGEO Gene Perturbation Signatures 1.0 null ILKAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74303 Colorectum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 TTLL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.23845 ELF1-20517297-JURKAT-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null primary motor cortex (area M1, area 4)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.69404 Neurodegenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.41 ZNF385A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74204 frontal pole, right, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.913877 SET2 CCLE Cell Line Gene CNV Profiles -1.0 -2.24782 TCF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.2859 H1 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 0.837774 NCOA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5654 FOXA1_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2452 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.932161 GNPNAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14977 GTEX-S4UY-0126-SM-3K2BB GTEx Tissue Sample Gene Expression Profiles 1.0 2.61292 STAT6 MotifMap Predicted Transcription Factor Targets 1.0 null NCIH1915 CCLE Cell Line Gene CNV Profiles 1.0 1.42814 GA10 CCLE Cell Line Gene Expression Profiles 1.0 1.97784 Lung adenocarcinoma_LUAD_TCGA-67-6216-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Autoimmune disease of musculoskeletal system DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.032 Nuclear outer membrane-endoplasmic reticulum membrane network COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 CARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6871 Infundibulum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.268 SU-DHL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.5918 medial parabrachial nucleus,right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.33372 primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.5408 GSE130081,GSE130082_4_v_1_neil2_mouse RummaGEO Gene Perturbation Signatures 1.0 null ventricular (matrix) zone of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.50345 response to ph GO Biological Process Annotations 2015 1.0 null GTEX-WFG7-1126-SM-4LMK3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.842809 Brain Lower Grade Glioma_LGG_TCGA-HT-7873-01B-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Stearic acid HMDB Metabolites of Enzymes 1.0 null GTEX-XUJ4-2426-SM-4BOO3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.4759 GSE148692,GSE148695_7_v_6_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A0VN-01A-21R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18131 Cer(d18:0/24:0) HMDB Metabolites of Enzymes 1.0 null CCDC69 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99977 r8 part of inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40803 CALU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61361 EHD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14153 CRAMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57458 NUSAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80935 LPP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7796 Galactosylceramide (d18:1/22:0) HMDB Metabolites of Enzymes 1.0 null stratum spinosum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.456442 Upper epidermis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.72 CUEDC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17697 Galactosylceramide (d18:1/18:1(9Z)) HMDB Metabolites of Enzymes 1.0 null GARIN1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0548 NKX3-1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58826 RAD21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9756 ZNF804B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01525 inner CP in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.968769 C4orf46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47123 SA1-27219007-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-XBED-1026-SM-48TCB GTEx Tissue Sample Gene Expression Profiles 1.0 0.858346 SP in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.991195 membrane lipid biosynthetic process GO Biological Process Annotations 2025 1.0 null Farber lipogranulomatosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.728 Bladder TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 TRMT10B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84624 hsa-miR-4733-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 GSE118077_1_v_8_sprr5_human RummaGEO Gene Perturbation Signatures -1.0 null ZNF135 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 68.4019 Dihydroceramide HMDB Metabolites of Enzymes 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2952-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AR ChEA Transcription Factor Targets 1.0 null Hypertrophy CTD Gene-Disease Associations 1.0 1.08091 DMD_Deficiency_GDS2996_614_mouse_Cardiac muscles from 10.5-month (mdx animals) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null erythroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.164091 SNU410 CCLE Cell Line Gene Expression Profiles -1.0 -1.59162 polysensory temporal cortex (area 22p) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.872209 Cer(d18:0/12:0) HMDB Metabolites of Enzymes 1.0 null abnormality of the prostate GWASdb SNP-Phenotype Associations 1.0 0.522707 bone marrow HPA Tissue Protein Expression Profiles -1.0 -0.7012 GTEX-WHSE-0126-SM-3NMBT GTEx Tissue Sample Gene Expression Profiles 1.0 0.978914 Ebolavirus(ZEBOV)_1day_Liver_None_GSE57214 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.66451 amygdaloid complex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.32615 Primary visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45859 ZNF19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54565 subbrachial nucleus, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15541 membrane part GO Cellular Component Annotations 2015 1.0 null Atopic dermatitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.328 Sarcoma_SARC_TCGA-DX-A3U6-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE148695,GSE167281_2_v_1_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null membrane lipid catabolic process GO Biological Process Annotations 2025 1.0 null phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.802966 system GeneRIF Biological Term Annotations 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7H5-01B-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27207 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A2QG-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FTC133 CCLE Cell Line Gene CNV Profiles 1.0 1.32815 CCND1 ChEA Transcription Factor Targets 1.0 null abnormality of the genitourinary system GWASdb SNP-Phenotype Associations 1.0 0.055882 pallidal amygdala Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4069 MRPL34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22921 GTEX-U8XE-0326-SM-3DB8P GTEx Tissue Sample Gene Expression Profiles 1.0 1.4516 Lung squamous cell carcinoma_LUSC_TCGA-68-7755-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.850862 NCI-H2009 COSMIC Cell Line Gene Mutation Profiles 1.0 null DNASE1L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56096 DAG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11101 Mannosyl-inositol-phosphorylceramide HMDB Metabolites of Enzymes 1.0 null PMC7825356-8844261.f3.docx-155-CREB3L3_CREB3L3 Rummagene Transcription Factor Associations 2026 1.0 null NCI-H446 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0734 increased epididymal fat pad weight MGI Mouse Phenotype Associations 2023 1.0 null MCF7 CCLE Cell Line Gene CNV Profiles -1.0 -1.96412 Brain Lower Grade Glioma_LGG_TCGA-CS-6667-01A-12R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null bounding membrane of organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.002594 Respiratory system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Folium-tuber vermis (VII) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.90727 DACH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25179 rnf2_20123906_mouse_embryonic_stem_cell_lof_mouse_gpl1261_gse19076 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.172637 PCDHB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92823 GTEX-PLZ6-0526-SM-3P61C GTEx Tissue Sample Gene Expression Profiles 1.0 0.959134 PDE7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91809 Anteromedial visual area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30527 PMC12717993-MEC-34-e17796-s002.xlsx-ST12_WGS_RFMix_genes_2_anc-Unnamed_14_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XV7Q-1826-SM-4BRUV GTEx Tissue Sample Gene Expression Profiles 1.0 1.20807 caudal portion of VFC (area 44) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.37196 H3K4me1_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null CERS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57571 KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.41064 Perturb_12223_KD_CASZ1_SRP267080 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.56641 Sphingosine HMDB Metabolites of Enzymes 1.0 null rostral subdivision of medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.04767 TMEM160 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66574 C4orf48 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63872 MGE-Lateral region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08872 SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.843499 m1B part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03741 Polar nucleus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.527 496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.23752 CAKI-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.34522 Prostate adenocarcinoma_PRAD_TCGA-HC-8260-11A-01R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BHLHE22 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.3717 ZNF835 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37121 AU565 CCLE Cell Line Gene CNV Profiles -1.0 -1.41979 CCNA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51545 single-organism biosynthetic process GO Biological Process Annotations 2015 1.0 null hydrolase activity, hydrolyzing O-glycosyl compounds GO Molecular Function Annotations 2023 1.0 null COV362 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.42254 SKOR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22509 SCAMP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01865 ACY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54119 CEP41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.75812 Gustatory areas, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.97516 abnormal hair shaft morphology MGI Mouse Phenotype Associations 2023 1.0 null Sporangiospore TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.517 Posterior complex of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08445 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6943-11A-01R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Paramedian lobule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4938 Lactosylceramide (d18:1/24:0) HMDB Metabolites of Enzymes 1.0 null organonitrogen compound biosynthetic process GO Biological Process Annotations 2015 1.0 null WM3211 DepMap CRISPR Gene Dependency 1.0 2.0848 Hair shaft TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.275 LN382 CCLE Cell Line Gene Expression Profiles 1.0 1.42781 REST ChEA Transcription Factor Targets 1.0 null salivarygland BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.911972 Ceramide (d18:1/24:0) HMDB Metabolites of Enzymes 1.0 null GSE148692,GSE148695_5_v_6_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null OVCAR-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.841244 Ceramide (d18:1/20:0) HMDB Metabolites of Enzymes 1.0 null hacer1 GeneRIF Biological Term Annotations 1.0 null Stratum corneum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.726 PPT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57542 Perturb_14919_KO_Polr2a_SRP181107 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.78805 SERPINF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.33778 nucleus coeruleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.875245 periventricular stratum of m1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.91531 ABCF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02961 organic substance catabolic process GO Biological Process Annotations 2015 1.0 null GSE148692,GSE148695_2_v_6_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null amygdaloid complex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.841321 GTEX-QDVN-2026-SM-3GAEP GTEx Tissue Sample Gene Expression Profiles 1.0 1.17759 GUCD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4847 dorsolateral prefrontal cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.25265 Autosomal recessive congenital ichthyosis 4B DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.408 PRODH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3307 liminal alar domain of m2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53133 membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68G-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.967715 r7 part of the posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.88511 GTEX-R55G-2526-SM-2TC6D GTEx Tissue Sample Gene Expression Profiles 1.0 1.2048 GFI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.8857 ovary HPA Tissue Protein Expression Profiles -1.0 -1.44641 RFX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.4208 GTEX-T6MO-1626-SM-32QOM GTEx Tissue Sample Gene Expression Profiles 1.0 1.48122 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO Molecular Function Annotations 2015 1.0 null SELENOH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33247 GTEX-TMMY-0226-SM-33HBA GTEx Tissue Sample Gene Expression Profiles 1.0 1.72274 Ovary BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.33629 SUMO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46197 CHAD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96183 GTEX-U3ZH-2026-SM-3DB78 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20026 cellular response to metal ion GO Biological Process Annotations 2015 1.0 null ZNF728 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44209 vitamin c_mus musculus_gpl6246_gse19378 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null interstitial nucleus of the posterior limb of the anterior commissure Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22966 496100418_TCx_no dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -5.63143 GTEX-UPIC-1626-SM-4IHKT GTEx Tissue Sample Gene Expression Profiles 1.0 1.50343 LMO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65476 DOTC24510 DepMap CRISPR Gene Dependency 1.0 2.15007 Hi-5 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.509 Pollen aperture COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.009 RHPN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37257 Preputial gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.712 GOLGA6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38285 RAB3GAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88741 Cer(d18:1/18:1(11Z)) HMDB Metabolites of Enzymes 1.0 null abnormality of the male genitalia GWASdb SNP-Phenotype Associations 1.0 0.200316 GTEX-SN8G-0126-SM-32PLI GTEx Tissue Sample Gene Expression Profiles 1.0 1.48029 MYOZ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.59066 lateral terminal nucleus of the accessory optic tract, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5193 GTEX-WHPG-2626-SM-3NMBR GTEx Tissue Sample Gene Expression Profiles 1.0 1.47638 STIMATE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97515 Megasporocyte nucleus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.526 MM1S CCLE Cell Line Gene CNV Profiles 1.0 1.60334 Niemann-Pick disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.552 cellular response to chemical stimulus GO Biological Process Annotations 2015 1.0 null GSE171837_3_v_1_bortezomib_mouse RummaGEO Drug Perturbation Signatures -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.4077 striatum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.42801 SW-403 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.185 Polar tube COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.565 NDUFA8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91832 endoplasmic reticulum membrane GO Cellular Component Annotations 2015 1.0 null p1Lim part of periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.05869 Hepatobiliary disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.349 Lung adenocarcinoma_LUAD_TCGA-MP-A4T9-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.853499 ZFR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57356 USP21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30845 cytoplasmic part LOCATE Curated Protein Localization Annotations 1.0 null abnormal oxygen consumption MPO Gene-Phenotype Associations 1.0 null LRRC14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23599 dorsolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.79992 GTEX-R53T-1126-SM-48FD4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.885451 GSE160083,GSE160084_1_v_0_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.54532 SU-DHL-6 COSMIC Cell Line Gene Mutation Profiles 1.0 null Hemispheric regions Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.024 organelle membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Leaflet of membrane bilayer COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.239 Gaucher's disease type I DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.222 Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.559 496100467_FWM_probable Alzheimer's disease_no TBI_89_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.42668 hsa-miR-4483 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 496100318_PCx_probable Alzheimer's disease_TBI_100+_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.23714 Inflammatory bowel disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.065 Corn ear TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.618 MAL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62474 response to chemical GO Biological Process Annotations 2015 1.0 null Glucosylceramide (d18:1/24:1(15Z)) HMDB Metabolites of Enzymes 1.0 null PMC8020666-pnas.2015855118.sd09.xlsx-LPS_4_human_DRSG_higherRes-Hg_gene_id_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null VARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70785 AM-38 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-QDVJ-1726-SM-2I5FX GTEx Tissue Sample Gene Expression Profiles 1.0 1.57485 GTEX-WYBS-0626-SM-3NMAS GTEx Tissue Sample Gene Expression Profiles 1.0 1.06665 Internal female genital organ TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Stratum granulosum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.008 Alzheimer's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.187 single-organism metabolic process GO Biological Process Annotations 2015 1.0 null dorsal lateral geniculate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.909232 decreased inguinal fat pad weight MGI Mouse Phenotype Associations 2023 1.0 null PMC6698381__F3 PFOCR Pathway Figure Associations 2024 1.0 null IV, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.824647 central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.99254 GTEX-UPIC-1026-SM-4IHLT GTEx Tissue Sample Gene Expression Profiles 1.0 0.845651 H2BC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53031 medial mammillary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.843093 Overnutrition DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.397 NCIN87 CCLE Cell Line Gene CNV Profiles -1.0 -1.84335 H3K4me1_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Immune system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.389 F36P CCLE Cell Line Gene CNV Profiles -1.0 -1.7777 Male inflorescence TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.595 sphingosine biosynthetic process GO Biological Process Annotations 2023 1.0 null MNX1-26342078-MIN6-4N-MOUSE ChEA Transcription Factor Targets 2022 1.0 null NOL4L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6795 NCIH1944 CCLE Cell Line Gene CNV Profiles -1.0 -1.49991 GSE210885_5_v_7_klf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null HS729 DepMap CRISPR Gene Dependency 1.0 3.17142 Tetrahexosylceramide (d18:1/24:0) HMDB Metabolites of Enzymes 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-4490-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TSPAN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97914 BALL-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null central medullary reticular group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.65303 abnormal sebaceous lipid secretion MGI Mouse Phenotype Associations 2023 1.0 null Galabiosylceramide (d18:1/22:0) HMDB Metabolites of Enzymes 1.0 null H3K4me1_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GARRE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81802 internal granular layer of CbHCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1417 FXYD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90273 mRNA_KLF4_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null superficial stratum of CoPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5193 BCP1 CCLE Cell Line Gene CNV Profiles 1.0 1.38035 BMI1-19503595-MEFC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_LF_species_not_found_in_common_genes_of_R_species_LTF Rummagene Transcription Factor Associations 2026 1.0 null cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 G121 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.855814 GTEX-PLZ5-2026-SM-2S1O4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.27695 Perturb_9778_KD_Gas41_SRP110498 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.90008 membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 KHM-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.984795 lysosomal storage disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.635135 Reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.058 Anteromedial nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.60058 epithelium development GO Biological Process Annotations 2015 1.0 null CLSTN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15211 ARHGEF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05506 NAA80 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68067 EPCAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40051 SET-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.07079 Perturb_3794_KO_Rnf20_ERP123195 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.9553 rostral presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1504 GTEX-XYKS-2126-SM-4E3IB GTEx Tissue Sample Gene Expression Profiles 1.0 1.1813 GTEX-T8EM-0526-SM-4DM64 GTEx Tissue Sample Gene Expression Profiles 1.0 0.997695 TAF6L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.286 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GTEX-WK11-2726-SM-3NMAQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.04192 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NF-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE101112_0_v_4_j147_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XOTO-0726-SM-4B659 GTEx Tissue Sample Gene Expression Profiles 1.0 1.34249 Tongue-keratinocyte Tabula Sapiens Gene-Cell Associations 1.0 9.85355 vomeralnasalorgan.VMO. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.985104 abnormal zigzag hair morphology MGI Mouse Phenotype Associations 2023 1.0 null hippocampus HPA Tissue Protein Expression Profiles -1.0 -0.7012 GTEX-QEG4-0226-SM-2S1PY GTEx Tissue Sample Gene Expression Profiles 1.0 1.30862 HMEL CCLE Cell Line Gene Expression Profiles 1.0 2.11626 MYC-19030024-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-QESD-1426-SM-2S1R9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.28337 TWSG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50776 Lamellar body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.35 Galactosylceramide (d18:1/12:0) HMDB Metabolites of Enzymes 1.0 null Primary somatosensory area, lower limb, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56781 Guard cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.074 PIAS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54088 CAL33 CCLE Cell Line Gene Expression Profiles -1.0 -1.66701 Posterior parietal association areas, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.24601 HEC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Glucosylceramide (d18:1/25:0) HMDB Metabolites of Enzymes 1.0 null NANOGNB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45501 Reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 layer 3 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01822 Arteriosclerotic cardiovascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.156 FOXD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27199 WDR73 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26411 RCOR3 ChEA Transcription Factor Targets 1.0 null PMC7880379-aging-13-202285-s003.xlsx-DElncRNA_target-FEZF1_FEZF1 Rummagene Transcription Factor Associations 2026 1.0 null Zona incerta Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20161 TELO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8273 HCC1195 CCLE Cell Line Gene CNV Profiles -1.0 -2.27587 Ceramidase InterPro Predicted Protein Domain Annotations 1.0 null response to stimulus GO Biological Process Annotations 2015 1.0 null RFXANK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37208 SNU213 CCLE Cell Line Gene Expression Profiles -1.0 -1.81456 abnormal hair follicle development MGI Mouse Phenotype Associations 2023 1.0 null GSE183606_1_v_0_rutaecarpine_human RummaGEO Drug Perturbation Signatures 1.0 null lateral part of preisthmic periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01265 HMX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57361 BMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77752 GTEX-OXRP-0926-SM-48TC1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.981684 SPAG9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60593 mediodorsal nucleus of thalamus_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04205 regulation of metabolic process GO Biological Process Annotations 2015 1.0 null Sarcoma_SARC_TCGA-WK-A8XQ-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POM121 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20954 GTEX-X4EP-0126-SM-3P5YV GTEx Tissue Sample Gene Expression Profiles 1.0 1.40796 FAM241B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33715 GTEX-VUSG-1226-SM-4KKZF GTEx Tissue Sample Gene Expression Profiles 1.0 0.867957 POU2AF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73155 TMEM240 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53743 Primary somatosensory area, barrel field, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29347 GTEX-QDVJ-0726-SM-48U1W GTEx Tissue Sample Gene Expression Profiles 1.0 0.848325 Acute myeloid leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.116 subbrachial nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11857 striatal amygdala Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39682 VIIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.07015 membrane lipid biosynthetic process GO Biological Process Annotations 2023 1.0 null ONS76 CCLE Cell Line Gene CNV Profiles -1.0 -1.35917 MOLM-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.932161 oculomotor nuclear complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.33378 organelle membrane GO Cellular Component Annotations 2015 1.0 null PTPRU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63001 intermediate stratum of PcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.83532 Prostate adenocarcinoma_PRAD_TCGA-EJ-7327-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ACOT9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40562 Primary somatosensory area, trunk, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1111 KHM1B CCLE Cell Line Gene CNV Profiles 1.0 1.76392 Acute Myeloid Leukemia_LAML_TCGA-AB-2867-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JcPV part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.35769 Adrenocortical carcinoma_ACC_TCGA-OR-A5LO-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC5380038__F2 PFOCR Pathway Figure Associations 2024 1.0 null FSTL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77051 PIAS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46308 PLEKHG5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45158 trachea BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.40894 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.495 ZNF333 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19761 Sphingosine MW Enzyme Metabolite Associations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6961-11A-01R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null t69-brown-adipose_female_1w MoTrPAC Rat Endurance Exercise Training -1.0 -6.14985 GTEX-XYKS-1526-SM-4BRUP GTEx Tissue Sample Gene Expression Profiles 1.0 0.951859 frontalcortex BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.860955 POLH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22551 GSE198165,GSE198166_0_v_3_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null Spinal muscular atrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.171 endoplasmic reticulum membrane GO Cellular Component Annotations 2023 1.0 null ADRB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63127 Acute Myeloid Leukemia_LAML_TCGA-AB-2908-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-UPJH-0326-SM-3GADU GTEx Tissue Sample Gene Expression Profiles 1.0 1.41214 Prostate adenocarcinoma_PRAD_TCGA-G9-6353-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF652 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6609 KYSE-270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.885208 GTEX-Q2AI-0626-SM-48TZU GTEx Tissue Sample Gene Expression Profiles 1.0 0.875693 SNUC5 DepMap CRISPR Gene Dependency 1.0 2.03381 Obesity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.398 ZNF280D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.13373 TOM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80321 PMM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80291 Pyramus (VIII), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38362 RPRD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93819 DUSP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28092 RNPEPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.587 primary motor cortex (area M1, area 4)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.28622 Tetrahexosylceramide (d18:1/18:0) HMDB Metabolites of Enzymes 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7782-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medial basal reticular formation of m1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20884 phosphate GeneRIF Biological Term Annotations 1.0 null GTEX-OXRP-0126-SM-3NB32 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09751 RNF146 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71855 r10 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.02335 bounding membrane of organelle GO Cellular Component Annotations 2015 1.0 null GSE107505_1_v_2_nanog_mouse RummaGEO Gene Perturbation Signatures 1.0 null superior frontal gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.27502 CardiacMyocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.7141 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO Molecular Function Annotations 2015 1.0 null GOLT1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59797 molecular layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.962243 Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7X1-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of CoPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.1096 Folium-tuber vermis (VII), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.91628 496100622_HIP_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.11888 abnormal joint morphology GWASdb SNP-Phenotype Associations 1.0 0.215632 organelle LOCATE Curated Protein Localization Annotations 1.0 null abnormal coat/ hair morphology MGI Mouse Phenotype Associations 2023 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RP-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FADU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.88424 CCDC160 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30343 Epidermal lamellar body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.693 PPARG JASPAR Predicted Transcription Factor Targets 1.0 null GSE182680,GSE182683_0_v_12_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null PRKCZ_KO_GDS4310_293_mouse_heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null CKLF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32368 intracellular organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GTEX-XXEK-2226-SM-4BRUM GTEx Tissue Sample Gene Expression Profiles 1.0 1.20285 Lactosylceramide (d18:1/24:1(15Z)) HMDB Metabolites of Enzymes 1.0 null PEO4 DepMap CRISPR Gene Dependency 1.0 2.58106 COX14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57156 NCIH2452 DepMap CRISPR Gene Dependency 1.0 3.37433 layer III of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.27957 SHROOM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86217 Golgi apparatus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.004 SFPQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89495 PARP12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94913 GSE171724_1_v_5_ezh2_mouse RummaGEO Gene Perturbation Signatures -1.0 null AMD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34579 Hair follicle bulge TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.071 NCIH28 DepMap CRISPR Gene Dependency 1.0 3.15136 GTEX-XQ3S-1426-SM-4BOPR GTEx Tissue Sample Gene Expression Profiles 1.0 1.13668 cellular_component GO Cellular Component Annotations 2015 1.0 null PPP2R3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88784 layer II of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.988736 BORCS8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25803 TBC1D25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76973 ZNF416 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71222 CAOV4 DepMap CRISPR Gene Dependency 1.0 5.14267 Trihexosylceramide (d18:1/22:0) HMDB Metabolites of Enzymes 1.0 null PMC10214295-mmc4.xlsx-A_-_Human_Islets_ZBTB16_targets-Ensembl_Gene_ID_ZBTB16 Rummagene Transcription Factor Associations 2026 1.0 null HMGN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08779 NB10 DepMap CRISPR Gene Dependency 1.0 6.70299 Mesothelioma_MESO_TCGA-LK-A4O6-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10214295-mmc4.xlsx-B_-_Beta_Cell_ZBTB16_targets-Gene_Name_ZBTB16 Rummagene Transcription Factor Associations 2026 1.0 null IDI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52126 Keratohyalin granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.754 p1B part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27413 hsf1_00000000_tcell_lof_mouse_gpl1261_gse41005 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.144373 skin_6a HPA Tissue Sample Gene Expression Profiles 1.0 1.6108 BPGM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62144 PMC12068594-pgen.1011693.s007.xlsx-MCR_vs_MCW-gene_id_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null CHPT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70207 Artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.364 GSE239373_0_v_1_mettl3_mouse RummaGEO Gene Perturbation Signatures -1.0 null Ceramide (d18:1/25:0) HMDB Metabolites of Enzymes 1.0 null sphingoid metabolic process GO Biological Process Annotations 2015 1.0 null Foot layer COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.059 LRRC4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19367 ZFPM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51232 GSE146894_3_v_8_hira_mouse RummaGEO Gene Perturbation Signatures 1.0 null IRX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.09264 ventrolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.64777 GTEX-SNMC-0926-SM-4DM5U GTEx Tissue Sample Gene Expression Profiles 1.0 0.83458 GSE149903_4_v_2_myd88_mouse RummaGEO Gene Perturbation Signatures 1.0 null hippocampus (hippocampal formation)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.894558 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TU-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KCTD17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91449 high-density lipoprotein particle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.778 XRCC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77053 GSE234340_10_v_2_muc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE143955_1_v_2_ripk1_mouse RummaGEO Gene Perturbation Signatures -1.0 null 496100522_PCx_dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.35906 RGS14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.97119 GTEX-P4QT-0626-SM-3NMCP GTEx Tissue Sample Gene Expression Profiles 1.0 0.85152 mediodorsal nucleus of thalamus_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.981711 abnormal hair cuticle MGI Mouse Phenotype Associations 2023 1.0 null HIV_Infected-mDC_None_GSE42058 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.73285 SP in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.47614 ceramide catabolic process GO Biological Process Annotations 2023 1.0 null CD33+_Myeloid BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.04488 Trihexosylceramide (d18:1/20:0) HMDB Metabolites of Enzymes 1.0 null 59M CCLE Cell Line Gene Expression Profiles -1.0 -2.41507 cortex of cerebellar hemisphere Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12188 osteoclasts BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.880075 ETV2-25802403-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null ventrolateral part of alar m1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.40719 layer 6 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36239 endoplasmic reticulum membrane GO Cellular Component Annotations 2025 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2869-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE60837_0_v_4_bcl9_mouse RummaGEO Gene Perturbation Signatures 1.0 null HES5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89607 OVISE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.824392 Adrenocortical carcinoma_ACC_TCGA-OR-A5K0-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferior occipital gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.84519 polymorphic layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.842871 PHOX2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02817 CITED4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57055 GSE199899_4_v_0_diethylnitrosamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null MYC-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Urinary system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 VSNL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2851 LARP4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69795 PMC7145850__F3 PFOCR Pathway Figure Associations 2024 1.0 null LXFL529 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.68978 EHF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92793 trochlear nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.99273 GSE203308_7_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.416 GTEX-RVPU-2226-SM-2XCAQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.45904 Cer(d18:0/16:0) HMDB Metabolites of Enzymes 1.0 null Urinary tract TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 CHAGOK1 CCLE Cell Line Gene CNV Profiles -1.0 -2.32719 membrane lipid catabolic process GO Biological Process Annotations 2015 1.0 null Nucleus x Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16202 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D6-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal coat appearance MPO Gene-Phenotype Associations 1.0 null GSE203158_0_v_15_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null SLC27A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83132 adult stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058739 GSE148692,GSE148695_2_v_4_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Hypotrichosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.23 Lung adenocarcinoma_LUAD_TCGA-44-2666-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ascl2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 47.6665 Steatotic liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.349 differentiation GeneRIF Biological Term Annotations 1.0 null UBXN7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17196 primary auditory cortex (core)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.24876 superficial layers of caudal presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14645 integral component of membrane GO Cellular Component Annotations 2015 1.0 null UMRC6 CCLE Cell Line Gene CNV Profiles -1.0 -1.48302 Lung squamous cell carcinoma_LUSC_TCGA-77-8131-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null amygdalohippocampal transition zone, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.00508 BMI1 ChEA Transcription Factor Targets 1.0 null GSE147056_3_v_1_actl6b_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-T6MN-0126-SM-32PLP GTEx Tissue Sample Gene Expression Profiles 1.0 1.83251 UHMK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27615 GTEX-XPVG-2626-SM-4B669 GTEx Tissue Sample Gene Expression Profiles 1.0 1.42347 cerebellar cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.70158 GSE145215_2_v_1_krt13_mouse RummaGEO Gene Perturbation Signatures 1.0 null HCFC1R1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14245 PAIP2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71823 GTEX-PLZ6-1426-SM-2S1OQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.48135 VZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03512 intracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GTEX-X261-0126-SM-3NMD6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.36318 Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-A5NK-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.22183 POLR2AphosphoS2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X3Y1-2026-SM-3P5YM GTEx Tissue Sample Gene Expression Profiles 1.0 1.22884 striatum_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.945875 H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HOOK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67357 GSE182680,GSE182683_0_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null Myristic acid HMDB Metabolites of Enzymes 1.0 null interstitial nucleus of Cajal, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.0611 Sphingolipid pathway WikiPathways Pathways 2024 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-5849-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GM2 gangliosidosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.033 posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.990203 SK-MEL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.857019 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_66_KLF4 Rummagene Transcription Factor Associations 2026 1.0 null Lactosylceramide (d18:1/26:1(17Z)) HMDB Metabolites of Enzymes 1.0 null intracellular membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null SLC25A35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82524 GTEX-WFON-2126-SM-3LK7O GTEx Tissue Sample Gene Expression Profiles 1.0 1.56118 RXRA::VDR JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.9 MMGT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75102 ADCY3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65374 hematopoietic stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063205 PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1 Rummagene Transcription Factor Associations 2026 1.0 null RNF25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52634 disease GWASdb SNP-Disease Associations 1.0 0.028674 GSE178255_1_v_0_tlr4_mouse RummaGEO Gene Perturbation Signatures -1.0 null ARID4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75743 ChIP_KLF4_19030024 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GSE112763,GSE112767_2_v_3_dgcr8_mouse RummaGEO Gene Perturbation Signatures -1.0 null ELOB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.13036 ventrolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.35032 CELF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29496 Inferior colliculus, central nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03741 GTEX-PWCY-0726-SM-48TCS GTEx Tissue Sample Gene Expression Profiles 1.0 1.01736 sebaceous gland hypertrophy MGI Mouse Phenotype Associations 2023 1.0 null IRX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88158 PMC7304214-40170_2020_217_MOESM6_ESM.xlsx-Lipid_signaling_13_c_UP-Li_et_al_2018_GSE88752_Linking_prostate_cancer_cell_AR_heterogeneity_to_distinct_castration_and_enzalutamide_responses_AR Rummagene Transcription Factor Associations 2026 1.0 null parvocellular part of r8LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43965 Tetrahexosylceramide (d18:1/25:0) HMDB Metabolites of Enzymes 1.0 null GTEX-XUZC-1726-SM-4BRWS GTEx Tissue Sample Gene Expression Profiles 1.0 2.50681 Diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.544 Primary somatosensory area, barrel field, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.02564 cellular nitrogen compound biosynthetic process GO Biological Process Annotations 2015 1.0 null Lactosylceramide (d18:1/25:0) HMDB Metabolites of Enzymes 1.0 null orbital frontal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05177 Sarcoma_SARC_TCGA-SI-AA8C-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-UJMC-0926-SM-4IHLK GTEx Tissue Sample Gene Expression Profiles 1.0 0.839528 OB olfactory fiber layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15881 ZFY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86873 Fiddlehead TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.72 membrane GO Cellular Component Annotations 2015 1.0 null hematopoietic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054439 H2AB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14457 organonitrogen compound biosynthetic process GO Biological Process Annotations 2023 1.0 null GSE241622_1_v_0_ythdc2_human RummaGEO Gene Perturbation Signatures -1.0 null Cer(d18:0/22:0) HMDB Metabolites of Enzymes 1.0 null EOMES_OE_GDS5077_65_human_RUES2 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Lymphoma_burkitts(Raji) BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.61892 Large intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 TFAP4::FLI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.8863 Paraflocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52814 abnormal hair growth IMPC Knockout Mouse Phenotypes 1.0 null N-acylsphingosine amidohydrolase activity GO Molecular Function Annotations 2023 1.0 null TMEM88B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75684 STBD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78429 ZNF557 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56706 ASS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66802 KLF7_KO_GDS2069_68_mouse_olfactory epithelia GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null abnormal eye pigmentation MPO Gene-Phenotype Associations 1.0 null MDAPCA2B CCLE Cell Line Gene Expression Profiles 1.0 3.40795 GTEX-XQ8I-1526-SM-4BOOH GTEx Tissue Sample Gene Expression Profiles 1.0 0.82959 Glucosylceramide (d18:1/12:0) HMDB Metabolites of Enzymes 1.0 null ACHE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76667 RESF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39227 SEPTIN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9302 epidermis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.245491 TRUB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89187 ACO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00725 ANKLE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04397 layer 3 of LPrP cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.74787 Perturb_4586_KO_Socs3_SRP099234 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 13.314 PHOX2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24729 TOMM34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7393 PTPRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04314 EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ADPRS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20588 inner portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.12851 ITPRID2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15805 Central amygdalar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.16719 Urinary bladder TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 ZNF585A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.58656 PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_CCRFCEM_ChIP-seq_TCF12 Rummagene Transcription Factor Associations 2026 1.0 null CMPK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10269 GTEX-R55G-1026-SM-48FDI GTEx Tissue Sample Gene Expression Profiles 1.0 0.943166 increased food intake MGI Mouse Phenotype Associations 2023 1.0 null RASGRP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91374 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.864 GTEX-SE5C-1126-SM-4BRWZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.913429 Paraflocculus, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21751 MSRB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60459 TGIF2LX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.9796 TOP3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22237 NCI-H889 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.86155 STK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80056 IZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13693 FADS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17728 H3K27me3_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S341-1726-SM-3K2AK GTEx Tissue Sample Gene Expression Profiles 1.0 2.81764 GTEX-T5JC-1726-SM-4DM6U GTEx Tissue Sample Gene Expression Profiles 1.0 0.886221 ventrolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.952923 parvocellular part of the r9LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.6122 GTEX-XAJ8-0826-SM-47JY6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.70002 Lactosylceramide (d18:1/16:0) HMDB Metabolites of Enzymes 1.0 null Retinitis pigmentosa 20 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.133 NCI-H2795 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.06959 GSE183994_1_v_0_scml2_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC7429792-40104_2020_487_MOESM3_ESM.xlsx-MSC_enriched_miRNA_target-NAME_MSC Rummagene Transcription Factor Associations 2026 1.0 null PIWIL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04908 PMC12178384-mmc6.xlsx-Sheet1-Supp_Table_4_Differential_expression_analysis_of_CIC-rearranged_sarcomas_vs_CIC-rearranged-like_sarcomas_CIC Rummagene Transcription Factor Associations 2026 1.0 null CAKI2 CCLE Cell Line Gene Expression Profiles -1.0 -1.62243 MAX ENCODE Transcription Factor Targets 1.0 null pyramidal layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.919321 Adrenocortical cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.687 EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4PP-0126-SM-3LK69 GTEx Tissue Sample Gene Expression Profiles 1.0 1.69609 GTEX-O5YV-1026-SM-3LK72 GTEx Tissue Sample Gene Expression Profiles 1.0 0.924015 Genital Diseases, Female CTD Gene-Disease Associations 1.0 1.14507 MMP19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43359 GTEX-P4PQ-0126-SM-2S1NM GTEx Tissue Sample Gene Expression Profiles 1.0 1.23567 GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GM1 gangliosidosis type 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.211 ETV2::FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.6888 trochlear nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.11938 HSFX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88967 upper (rostral) rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.897153 superficial stratum of PcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42675 Musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.154 Atherosclerosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.156 r10 basal plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0271 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1MI-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7183-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.2228 blastocysts BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.931232 Filiform apparatus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.276 H2AC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.43353 SSR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39625 CDC42BPB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1989 Coronary artery smooth muscle cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.504 superficial stratum of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11143 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null GSE252864_0_v_3_smad4_mouse RummaGEO Gene Perturbation Signatures -1.0 null WIDR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09215 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RR-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYCN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25429 ventrolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.76007 EP300_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.184 GSE148066,GSE157787_0_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null cellular response to metal ion GO Biological Process Annotations 2025 1.0 null Glucosylceramide (d18:1/20:0) HMDB Metabolites of Enzymes 1.0 null skin development GO Biological Process Annotations 2023 1.0 null GTEX-XQ8I-0926-SM-4BOOF GTEx Tissue Sample Gene Expression Profiles 1.0 1.41111 GTEX-T5JW-1626-SM-3GADZ GTEx Tissue Sample Gene Expression Profiles 1.0 2.20675 NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.824392 retrotrapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12874 decreased body weight MGI Mouse Phenotype Associations 2023 1.0 null P12ICHIKAWA CCLE Cell Line Gene Expression Profiles 1.0 1.61765 Hair disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.19 EIF3H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00877 TRIM27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6881 tail of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.19789 organ system cancer GWASdb SNP-Disease Associations 1.0 0.040673 GSE70499_5_v_7_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Spinal muscular atrophy with progressive myoclonic epilepsy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.214 GTEX-WEY5-2326-SM-3GIKK GTEx Tissue Sample Gene Expression Profiles 1.0 1.1703 GATA3-21867929-TH1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Lamellar body membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.793 GTEX-WH7G-2026-SM-3NMBL GTEx Tissue Sample Gene Expression Profiles 1.0 1.11327 orbital frontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.869796 globose nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.962658 epidermis development GO Biological Process Annotations 2015 1.0 null ZSCAN21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72328 GTEX-SIU8-0126-SM-2XCDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.09926 ventrolateral part of m2A Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53133 PHF21A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82669 rostral subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.87288 protein-cysteine S-palmitoyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.06 GCT COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-PWO3-1526-SM-48TCM GTEx Tissue Sample Gene Expression Profiles 1.0 1.22186 Female reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 LMO2 ChEA Transcription Factor Targets 1.0 null NCIH1836 CCLE Cell Line Gene CNV Profiles 1.0 2.176 G96 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30626 Tetrahexosylceramide (d18:1/12:0) HMDB Metabolites of Enzymes 1.0 null ERF::FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.381 intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 primary somatosensory cortex (area S1, areas 3,1,2)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.28911 C8orf58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77473 Galabiosylceramide (d18:1/20:0) HMDB Metabolites of Enzymes 1.0 null Ceramide (d18:1/9Z-18:1) HMDB Metabolites of Enzymes 1.0 null alopecia MGI Mouse Phenotype Associations 2023 1.0 null UBE2D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47157 Ptf1a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 76.0291 cellular response to calcium ion GO Biological Process Annotations 2015 1.0 null GSTM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70107 arthritis GWASdb SNP-Phenotype Associations 1.0 0.250554 Cer(d18:0/20:0) HMDB Metabolites of Enzymes 1.0 null Contact dermatitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.318 Metabolism of lipids and lipoproteins Reactome Pathways 2014 1.0 null HL-7702 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.707 Primary somatosensory area, trunk, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.11997 lipid storage disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.680697 superficial stratum of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.88608 abnormal posterior eye segment morphology MPO Gene-Phenotype Associations 1.0 null brownfat BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.46655 GTEX-U3ZM-0526-SM-4DXTB GTEx Tissue Sample Gene Expression Profiles 1.0 0.934284 Brain Lower Grade Glioma_LGG_TCGA-R8-A73M-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SYN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22533 Perturb_9776_KO_Mettl6_ERP120512 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -10.1091 layer 5 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40972 ZFP42 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.8447 Perturb_17486_KO_Otub2_SRP314435 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.61001 ROS50 DepMap CRISPR Gene Dependency 1.0 2.38108 Heptadecanoic acid HMDB Metabolites of Enzymes 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XD-01A-22R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SLU7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10788 ventral part of CoP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.1096 PIERCE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16973 GTEX-OIZG-0726-SM-33HBL GTEx Tissue Sample Gene Expression Profiles 1.0 1.91435 PANC0403 DepMap CRISPR Gene Dependency 1.0 2.05402 supraoptic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.17616 GTEX-U3ZN-0926-SM-4DXTU GTEx Tissue Sample Gene Expression Profiles 1.0 0.895729 Trihexosylceramide (d18:1/16:0) HMDB Metabolites of Enzymes 1.0 null Microsporangium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.57 WDCP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45193 hippocampus (hippocampal formation)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.18968 intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 MM.1S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.5049 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051222 PTGES2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51623 Skin BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.68156 MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15529 Keratin filament COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.636 RNF19B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5644 SCC-9 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10261 DETROIT 562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.49549 GPR150 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60993 molecular_function GO Molecular Function Annotations 2015 1.0 null intermediate stratum of m1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13055 esophagus_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.19321 prostate cancer GWASdb SNP-Disease Associations 1.0 0.61577 H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null lipid biosynthetic process GO Biological Process Annotations 2015 1.0 null NIH:OVCAR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35996 primary motor-sensory cortex (samples)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05089 SCRT2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.7697 mRNA_POU5F1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null CLPSL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61877 MTFP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51027 layer 1 of LPrP cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.75574 Edinger-Westphal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.38913 NPTXR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2339 periventricular stratum of m2AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01265 Heart BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.2475 SNU638 DepMap CRISPR Gene Dependency 1.0 3.61864 GSE139540_4_v_1_menadione_human RummaGEO Drug Perturbation Signatures -1.0 null EFM-192B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.966702 Lung adenocarcinoma_LUAD_TCGA-86-8671-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null NUDT15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91859 ADRA2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34595 GTEX-O5YT-0126-SM-48TBW GTEx Tissue Sample Gene Expression Profiles 1.0 1.19592 THP1 DepMap CRISPR Gene Dependency 1.0 3.5661 PRSS35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29071 ZNF653 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31701 TGIF2LY JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.0322 OCI-AML5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.942261 preisthmic midbrain tectum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.41674 NFIB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.0949 farber lipogranulomatosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.98203 PPP1R13L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44994 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7263-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NXF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39718 KPL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.48308 Perturb_5155_KD_Mbd3_SRP046299 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.34943 OLIG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32195 PARP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56103 PPARD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19772 Intracranial aneurysm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.622 ACSL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89805 JUN-21703547-K562-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null lateral part of m2A Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61537 cellular nitrogen compound biosynthetic process GO Biological Process Annotations 2023 1.0 null GTEX-XUW1-0926-SM-4BONX GTEx Tissue Sample Gene Expression Profiles 1.0 1.24167 Brain Lower Grade Glioma_LGG_TCGA-WY-A85C-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Quiescent skeletal muscle satellite cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.798