association	dataset	threshold value	standardized value
Adrenal gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN013_HEPG2_24H:N13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10526
ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.133982
myeloid progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068519
GSE63048_11_v_6_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257234
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	132.31
GSE127790_4_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
gonorrhea	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.318635
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
intestinal infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.219057
Hyperactive Behavior	DisGeNET Gene-Phenotype Associations	1.0	null
GSE127790_4_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TSPOAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52812
GSE148066,GSE157787_11_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE218060_2_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046467
nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.02988
FOSL1::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.123
CRCGN015_HEPG2_48H:A15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27948
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.744214
GSE87299_2_v_3_nr1d1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.400424
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.817616
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.276
GSE133683_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.712754
GSE152432_6_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EEF1A1	Hub Proteins Protein-Protein Interactions	1.0	null
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.49757
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredProteinGroups-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
nih-3t3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.394576
RPP30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41146
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NUP58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28689
CRCGN010_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.55489
Acute myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.26
thymus cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.077698
blastocyst	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.151041
Oocyst	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.74
GSE201042_6_v_7_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.496
extracellular non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.789191
female cone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.0282
breast cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.683919
GSE162739_8_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184884_7_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.926336
GSE248045,GSE248046_4_v_2_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
nuclear body	GO Cellular Component Annotations 2015	1.0	null
GSE220520_6_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147210_3_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.420036
GSE226114,GSE226116_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EE-01-DO31_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.312236
GSE196104,GSE196106_2_v_0_vsx2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
acute myeloid leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.083999
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.306805
NCI-H1781	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.91734
male reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.465723
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE183251_4_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
tongue epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.407453
6017_P2RY1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.503722
GSE216043_3_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE227891_5_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
chronic myeloid leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.3356
Mitochondrial respiratory chain complex III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.71
colon	HPA Tissue Protein Expression Profiles	-1.0	-1.05229
ink	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.24119
8651_TAF10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.692752
breast epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.285671
GSE137144_3_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2432
blood coagulation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.053161
colorectal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.670471
large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.318999
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_triplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.545868
GSE188458_2_v_1_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.702717
inflorescence	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.116439
GSE135350_2_v_7_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_13_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KMOE-2	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.94949
gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.394118
GSE180200,GSE180201_5_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169356_0_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
8903_TIAL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.578076
FOSL2::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2603
CRCGN017_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40738
CRCGN016_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.71347
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-4_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
caco-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.336704
PMC8141032-NIHMS1694738-supplement-Supplementary_Table_1.xls-MYC_BAF155_BRG1_BRD9-Nearest_Ensembl_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
exocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065453
JEG-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.754
CRCGN015_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02889
primary bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.054773
3871_HNRNPL_P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.672753
PMC11354204-JCB_202308099_TableS1.xlsx-TFEB-Flag_IP-Protein_name_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251723
GSE203308_15_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10244410-41467_2023_39054_MOESM5_ESM.xlsx-PIE-LIN28B-GeneSymbol_LIN28B	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1881
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.558644
CRCGN014_HEPG2_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.68734
HS-683 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.508
CRCGN015_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5848
trunk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.701899
CRCGN015_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.74449
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	106.233
GSE89154_1_v_0_proscillaridin_human	RummaGEO Drug Perturbation Signatures	1.0	null
thyroid cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.1145
MIR122_Antisense Inhibition_GDS1729_759_mouse_Livers (from C57BL/6 adult males)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
adenyl ribonucleotide binding	GO Molecular Function Annotations 2025	1.0	null
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Scape	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.785
liver	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.446807
496100463_FWM_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.16343
epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.974583
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MHH-NB-11	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.03772
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5994
TMCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18962
lymph	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.902745
GSE166536_3_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.09865
t-lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.109371
GSE138672_0_v_1_rabgef1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157592_1_v_0_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184210_0_v_3_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
chronic myeloid leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.152014
hematopoietic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.662336
CF-50-QK79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318199
PMC10243915-uxad037_suppl_supplementary_table_s1b-table_s3b.pdf-83-ZNF746_ZNF746	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.6322
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
496100473_TCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.32092
Leukemia	DisGeNET Gene-Disease Associations	1.0	null
GSE191105_2_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
1784_COPS7B_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.505396
rectal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.788547
GSE98898_7_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
nuclear body	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
nucleoplasm part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.905996
endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.163729
cajal body	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.311145
GSE169205_3_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.55713
cellular aromatic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE153871_5_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE130956_0_v_3_icaritin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE131649_6_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE161064,GSE161065_0_v_1_kdm5b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Carcinoma Of Larynx	DisGeNET Gene-Disease Associations	1.0	null
progressive myoclonus epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.163111
RBM28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.07235
adenylate kinase activity	GO Molecular Function Annotations 2015	1.0	null
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Ensembl_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11282827-40659_2024_524_MOESM5_ESM.xlsx-TAL1-sequence_name_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.51
GSE149359_3_v_1_asap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045486
nucleoside phosphate binding	GO Molecular Function Annotations 2015	1.0	null
nucleotide phosphorylation	GO Biological Process Annotations 2015	1.0	null
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE172146_2_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
8661_TAF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.513629
GSE162087_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE162739_6_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cardiomyocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.724
NFIX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.818
head and neck squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.232599
GSE179880_9_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1567
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147662_3_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
protein kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.129477
2796_EXOSC9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.632984
CRCGN016_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.21332
CRCGN012_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6551
GSE203308_7_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.052948
GSE123825_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151494_1_v_9_nrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
gastric cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.29996
liver cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.107647
GSE215351,GSE215794_1_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HS3ST3B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22859
GSE126777_3_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE94849_1_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
purification	GeneRIF Biological Term Annotations	1.0	null
496100461_PCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.10325
OTX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5707
SPDEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.423
plastid part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.05522
GOLT1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3139
purine nucleoside binding	GO Molecular Function Annotations 2015	1.0	null
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.299569
non-small cell lung cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.214765
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301935
GSE125007,GSE125008_10_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hypopharynx	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.28576
90S preribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.28
MID1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34221
CRCGN010_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.49705
CRCGN015_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6791
Estimated glomerular filtration rate	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.03979
rectal gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.26561
GSE109530,GSE109531_2_v_3_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.321072
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.1882
heterocyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
PC-3_[JPC-3]	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.3698
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.310318
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Congestive Heart Failure	DisGeNET Gene-Disease Associations	1.0	null
GSE200673,GSE200691_2_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.295
GSE93309_2_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.310059
thorax	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.683511
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.716828
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.9806
CRCGN012_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.4192
vertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.457214
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	191.818
disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045329
GSE157894_1_v_3_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
gastrointestinal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.335233
GSE149943_2_v_3_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Protein phosphatase inhibitor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.15
uterine leiomyoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.521223
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ps	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.511
blood vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.266069
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE139455_4_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.62385
496100551_PCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.23011
CRCGN015_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.62547
electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.082128
autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.054446
5658_NFYC_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.621975
hypopharyngeal squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.441042
301_ANAPC10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.67253
proteasome regulatory particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.171149
K-562	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.23446
GSE179880_1_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2632
sensory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.26516
CRCGN015_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.10332
non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.463198
cop9 signalosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.260566
NSMCE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27137
GSE232472_1_v_2_apoe_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11615365-41467_2024_54246_MOESM6_ESM.xlsx-KK47-Numb-KD_vs_Ctr-KD-ensemblGeneId_AR	Rummagene Transcription Factor Associations 2026	1.0	null
proteasome accessory complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.16935
female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.057007
adenyl ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
ZIC5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	97.1241
GSE120370_0_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
PMC12822963-pone.0339296.s005.xlsx-Sheet1-HIF1A_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166169_1_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.49875
nuclear body	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.086362
GSE102505_4_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.151266
GSE189653,GSE203344_4_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149903_5_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.37087
tafiid32	GeneRIF Biological Term Annotations	1.0	null
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112763,GSE112767_4_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.21054
CRCGN017_MCF10A.WT.HP_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0828
Flag leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.519
GSE182727_1_v_0_busulfan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Ribonuclease P complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.895
thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.545481
cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.533088
Cervical carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.173
Hepatocarcinogenesis	DisGeNET Gene-Disease Associations	1.0	null
GSE215351,GSE215794_7_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3397
CXCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2245
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.61941
GSE140322_3_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DC-93-NP78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207677
GSE231641_0_v_1_robo1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE198165,GSE198166_0_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-8_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
thyroid lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.667947
h9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.261624
GSE240896,GSE240899_3_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
DNMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33034
Jurkat	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.91694
SW1573	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.87168
DLG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17243
shigellosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.244696
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.291
C14orf28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85382
carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.12527
GSE236497,GSE236500_1_v_0_pemrametostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
sk-mel cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.231482
crypt	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.70108
CRCGN017_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.25315
transferase activity, transferring phosphorus-containing groups	GO Molecular Function Annotations 2015	1.0	null
GSE133213_2_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE113329,GSE113335_3_v_4_taf6l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.281
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.798541
GSE129465_3_v_2_phf6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hematopoietic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.477367
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	140.095
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.280315
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.912653
beckwith-wiedemann syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.513417
GSE135350_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nucleoside-triphosphatase activity	GO Molecular Function Annotations 2015	1.0	null
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.19275
RAB11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13226
CRCGN016_MCF10A.TP53.M_24H:D15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32158
GSE134375_0_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20484
myeloma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.087622
sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.890488
organelle part	GO Cellular Component Annotations 2015	1.0	null
GSE220520_3_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
non-membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.303871
PIAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18709
endocrine organ benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.059494
nucleoside monophosphate kinase activity	GO Molecular Function Annotations 2025	1.0	null
GSE180147_0_v_1_itga5_human	RummaGEO Gene Perturbation Signatures	1.0	null
small intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.422292
GSE77108_4_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05776
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.902745
Tic complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.699
nucleolus	GO Cellular Component Annotations 2025	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-5_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
heart muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.05229
GSE239578_0_v_6_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRCA1-A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.014
CRCGN015_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27864
Epithelioma	DisGeNET Gene-Disease Associations	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.39009
cellulosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.935488
transient cerebral ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.344207
crystal	GeneRIF Biological Term Annotations	1.0	null
vaccinia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.269043
single-organism process	GO Biological Process Annotations 2015	1.0	null
GSE188870,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
TUSC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9587
CRCGN008_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.05135
lymphocytic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.270561
nuclear lumen	GO Cellular Component Annotations 2025	1.0	null
RAD50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61094
GSE168797_1_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
fetus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05848
CRCGN014_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3938
UGGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53056
heterocycle metabolic process	GO Biological Process Annotations 2015	1.0	null
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
GB-73-QS80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212098
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290889
epidermal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063351
CRCGN017_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3765
RPL29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8096
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	84.7511
PMC11310865-jcav15p5118s1.pdf-15-DMTF1_DMTF1	Rummagene Transcription Factor Associations 2026	1.0	null
benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041903
CRCGN014_HEPG2_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.8999
496100628_FWM_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.13892
nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
Coleoptile	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.521
Metabolism of nucleotides	Reactome Pathways 2024	1.0	null
LC-1-sq	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.98056
GSE88819_1_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SYT13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05971
CRCGN008_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45755
Ribosome biogenesis in eukaryotes	KEGG Pathways 2026	1.0	null
GSE201239_3_v_4_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293445
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE160373_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hepatoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.125527
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216297
myoblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.152248
GSE153189_2_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Cleavage apparatus septin structure	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.61
colonic cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.793543
VDAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05383
GSE169205_3_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6605752-JEM_20181726_TableS1.xlsx-MYC_translational_targets-Table_S1_Lists_of_translational_targets_of_MYC_in_MYC_ON_vs_MYC_OFF_P493_cells_and_their_5_UTR_sequences_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
sup-t1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.297089
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.187
GSE231745_1_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
t-UTP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.598
pleura	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.196806
cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.221025
trophoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.078752
CDK8_knockdown_128_GSE30815	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.92741
CRCGN013_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16601
CRCGN015_HEPG2_48H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.50317
Phellem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.83
FAM204A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01033
HROB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99436
endocrine pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.088471
lymphoid tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.306805
4940_MED18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.632947
CRCGN014_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.36085
GSE205729,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mitochondrial intermembrane space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.254
CRCGN011_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1368
MAP1LC3B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27191
zygote	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.085062
9910_XRN1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.626891
NCI-H1963	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.7633
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8635
ESYT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75675
uterine cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.099042
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267711
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
2561_EIF4A3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.793316
GSE220520_6_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.324
CRCGN013_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2552
GSE185944_2_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ribonucleoside binding	GO Molecular Function Annotations 2015	1.0	null
CRCGN015_MCF10A_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0525
2633_EN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.528479
Infection By Cryptococcus Neoformans	DisGeNET Gene-Disease Associations	1.0	null
GSE73561,GSE73563_0_v_1_mef2c_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.192423
CRCGN017_MCF10A.TP53.M_24H:M02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05645
male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.31029
actin cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.233817
GSE202434,GSE202438_7_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.92394
7504_RPS15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.581848
neck	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057372
gastric cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.286736
GSE142019,GSE142021_1_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228181_2_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
multiple myeloma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.121117
CRCGN008_HEPG2_24H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2879
small molecule metabolic process	GO Biological Process Annotations 2015	1.0	null
MAFG::NFE2L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1129
Nuclear speckles	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.19014
GSE190947_1_v_0_xbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE95685_2_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0289
GSE211983_1_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.249
viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045896
spike	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.161945
trophoblast stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.305361
CRCGN016_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47562
nucleobase-containing compound kinase activity	GO Molecular Function Annotations 2015	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.89565
GSE196962_2_v_6_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE57871_1_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mammary epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.10611
6794_PRPF38A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.647761
GSE112860_0_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
WDR26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1514
EXOSC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36085
Nuclear speck	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
bronchogenic carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057899
CRCGN017_MCF10A.WT.HP_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0076
GSE183251_1_v_3_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.7714
PPP1R10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2414
ZNF724	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22446
Nucleolar preribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.752
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.01455
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
proton-transporting V-type ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.921
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.620621
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148269,GSE148273_0_v_1_arid4b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE224969,GSE224971_0_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AF-99-HA02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201602
GSE179002_3_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
pyrophosphatase activity	GO Molecular Function Annotations 2015	1.0	null
interleukin-23 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.857555
GSE86507,GSE86509_3_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UTP-C complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.772
hydrolase activity, acting on acid anhydrides	GO Molecular Function Annotations 2015	1.0	null
colonic cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.347778
GSE149903_5_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.641481
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5081
CRCGN015_MCF10A_48H:O24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04788
GSE171837_0_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CC2D1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24294
Dyskeratosis Congenita	DisGeNET Gene-Disease Associations	1.0	null
Mycobacterium Infection	DisGeNET Gene-Disease Associations	1.0	null
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
transcription	GeneRIF Biological Term Annotations	1.0	null
CD200	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34134
HNRNPAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30012
pleural fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.378748
KDM4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92239
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.589635
hct-116 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.510992
blastula	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.092474
Noc4p-Nop14p complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.069
SALL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4672
retinoblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.27083
5731_NOC4L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.537923
4939_MED17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.506806
acute lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.292436
intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.316456
Ookinete	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.042
CRCGN014_HEPG2_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06105
GSE201042_2_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.392
aortic smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.307528
DICER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16019
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.770451
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.7803
u-266 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.228497
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.688576
SP5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.651
lung	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.494528
GC-74-QF56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226393
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
DG-75	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.83365
SUPT6H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.16076
CRCGN016_MCF10A.WT.HP_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.08643
GSE198054,GSE198057_0_v_1_csf1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169205_0_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
JAK2_knockdown_192_GSE54645	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.77315
P32-ISH	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.84029
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.64875
GSE114992,GSE114993_0_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RNA polymerase I upstream activating factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.657
CRCGN017_MCF10A.WT.HP_24H:F23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.39205
nucleobase-containing small molecule metabolic process	GO Biological Process Annotations 2025	1.0	null
GSE116930,GSE116935_3_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
D-263MG	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.1839
cob	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.240826
nucleobase-containing small molecule metabolic process	GO Biological Process Annotations 2015	1.0	null
ALG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10728
cajal body	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.243158
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-TFDP1_TFDP1	Rummagene Transcription Factor Associations 2026	1.0	null
proteasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.557629
Noc complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.646
CRCGN016_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0363
lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.38552
WIL2-NS	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.9087
GSE202434,GSE202438_9_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SB-224289	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.52
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_hexaplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.344196
LRRC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23599
prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.317182
HCC1500	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.28056
Panicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.897
GSE211128_9_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.77745
SUPV3L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01229
GSE153189_2_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VAT1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18544
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
nucleoplasm part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.047065
GSE214442_0_v_1_pak4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
INCENP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57197
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211002
OAZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15316
reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.248905
eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.297806
GSE139540_0_v_2_menadione_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF740	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	167.228
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	120.543
LLGL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34764
GSE179880_2_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mitochondrial ribonuclease P complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.539
CRCGN015_MCF10A_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2974
GSE148193_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201239_3_v_2_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.129091
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
cyclin d1-cdk4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.690326
nucleoside phosphate metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
CRCGN017_MCF10A.WT.HP_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0933
GSE124375_13_v_12_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6024_PABPC1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.681145
nucleoplasm	GO Cellular Component Annotations 2015	1.0	null
MRPL38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0388
PMC10624900-41467_2023_42825_MOESM13_ESM.xlsx-Module_3-ZNF195_ZNF195	Rummagene Transcription Factor Associations 2026	1.0	null
8462_SSX2IP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.611542
cement gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.475423
Creatine kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.672
CRCGN011_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.36725
GSE149880_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ARH-77 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.615
chronic fatigue syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.332121
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224883
eye and adnexa disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.911433
uterine cervix	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.412011
GSE240027,GSE240030_5_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
8232_SNRPF_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.505742
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Diarrhea	DisGeNET Gene-Phenotype Associations	1.0	null
lung cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.372369
breast cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.53346
EXOSC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24645
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D1_1591_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
multiple myeloma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.114461
catalytic complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.064037
Preribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.628
nuclear lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.309
GSE198165,GSE198166_8_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.66141
GSE185944_2_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE73381,GSE73382_0_v_1_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ATP6V0D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20099
GSE126777_0_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular membraneless organelle	GO Cellular Component Annotations 2025	1.0	null
adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.104653
CRCGN015_MCF10A.TP53.M_24H:O24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.031
GSE129858,GSE129859_1_v_3_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0996
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE121824,GSE121826_0_v_2_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217132_0_v_1_pfkfb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ANXA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09957
organophosphate metabolic process	GO Biological Process Annotations 2015	1.0	null
ray	GeneRIF Biological Term Annotations	1.0	null
IC-05-AW29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214819
7059_RAD17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.533471
CRCGN016_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.21211
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.425298
GAL3ST4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24915
CRCGN011_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.76195
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.21974
GSE171401_1_v_0_adnp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE181492_1_v_0_chrysin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3835
XPO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2065
breast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.747102
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.46167
GSE101112_6_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
GSE131649_4_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09645
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.311
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE181003_1_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
organic cyclic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE86507,GSE86509_7_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GPR173	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55502
Reticular dysgenesis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.221
PMC10534007-Table_2.xlsx-S5_unique_up_MSC_B-721_elements_included_exclusively_in_BFTC905_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
cerebral cortex	HPA Tissue Protein Expression Profiles	-1.0	-0.791791
6537_POLR1D_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.521246
GSE75976_3_v_4_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180468_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
PRPF19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28571
GSE131649_4_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
germ cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.270909
GSE63048_11_v_8_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mammary epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.109569
CRCGN008_HEPG2_24H:F08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0345
ml-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.417718
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.3589
GSE140322_3_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZFYVE9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31776
5735_NOL6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.515796
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
blastomere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.088968
ZNF148	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	174.678
TAF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42321
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
T-REx 293 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.616
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.091
CRCGN015_MCF10A_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.318
GSE226249_5_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN016_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.88124
SPSB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10249
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE103068_0_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170066
C6orf141	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04742
GSE202434,GSE202438_6_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.15848
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7486
nucleus	GO Cellular Component Annotations 2025	1.0	null
leiomyoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.302838
GSE162623_0_v_1_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
mammary epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.117684
CRCGN017_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.53715
pancreatic islet	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.090998
GSE127790_6_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
retina	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.271256
ribonucleoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.051366
GSE211983_0_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.68
Gastroparesis	DisGeNET Gene-Disease Associations	1.0	null
GSE127790_10_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UBR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09696
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	GO Molecular Function Annotations 2015	1.0	null
adrenal gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE229309,GSE229314_4_v_1_elavl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.425726
CRCGN015_MCF10A_48H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32435
PMC12396377-jcb_202307079_tables1.xlsx-Fig_1C_i_-_iii_right-x_TFEB_KOcon_VS_WTcon_UP_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE110178_1_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8141032-NIHMS1694738-supplement-Supplementary_Table_1.xls-MYC_BAF155_BRG1_BRD9-Gene_Name_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
colonic epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.182969
GSE139966_1_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COL1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19211
extracellular region part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.326453
carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.410161
retinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.27039
Gin4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.61
GSE122215,GSE122217_5_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hydrolase activity	GO Molecular Function Annotations 2015	1.0	null
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.98465
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-1_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171837_0_v_3_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.089
CRCGN009_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45508
FOSL2::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2489
PRDX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44726
Nuclear splicing speckle	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.092691
smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.350743
GSE203158_0_v_13_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
acute myeloid leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.091829
HEY1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8626
PSMD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10728
intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE217541,GSE217543_0_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE218060_7_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
blast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.093462
PMC11686977-12967_2024_5960_MOESM9_ESM.xlsx-Sheet1-Supplementary_Table_4_The_co-precipitated_proteins_of_the_four_RORA_promoter_probes_P1_P2_P3_and_P4_and_beads_RORA	Rummagene Transcription Factor Associations 2026	1.0	null
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.6604
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.484376
GSE110268_1_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
ipi1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.734
GTPBP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09964
CRCGN017_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.76535
DUSP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57228
myoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.12503
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8134
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-10_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
ACSS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13891
pre-b acute lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.148507
CRCGN014_HEPG2_3H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6264
bone marrow cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060517
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043183
cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.096434
XRN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19202
GSE186660_2_v_1_nicotine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-7_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.00807
F8A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52585
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.27972
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-3_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186647,GSE217288_1_v_4_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.32701
phosphate-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
tongue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.356314
thymic carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.321181
Cervix disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.011
MAF::NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5128
GSE84922,GSE84924_4_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
respiratory epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.36526
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.730986
nuclear part	GO Cellular Component Annotations 2015	1.0	null
nucleotide metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE94814_2_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.39605
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
squamous cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.434523
MDA-MB-330	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.62098
11152_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.607827
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
Mitochondrial creatine kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.721
496100496_FWM_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.41382
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.610691
GSE92364_1_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
brain ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.169091
GSE185519_1_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE192771_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
colon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.731031
GSE145249_1_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
cyclin-dependent protein kinase holoenzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.851583
cajal body	GO Cellular Component Annotations 2015	1.0	null
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
transferase activity	GO Molecular Function Annotations 2015	1.0	null
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.91052
GSE166944_3_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216273,GSE216292_0_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
breast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.743389
CRCGN011_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.43355
epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.224893
GSE184892_4_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
plasma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.108784
pre-b acute lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.138137
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.19232
K562_Lenalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183845
sk-mel-28 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.273346
c2c12 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.24804
rectal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.788547
phosphorus metabolic process	GO Biological Process Annotations 2015	1.0	null
spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.219264
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223867
GSE130383_2_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
XRCC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06278
Interconversion of nucleotide di- and triphosphates	Reactome Pathways 2024	1.0	null
NHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.2005
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE179880_7_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Small ribosomal subunit processing complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.917
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE239578_2_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cardiac muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.63
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Nuclear body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.761
GSE240439_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE253041_3_v_0_ramp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NC-27-AD53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264988
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4122
GSE122067_2_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.279183
carbohydrate derivative binding	GO Molecular Function Annotations 2015	1.0	null
CRCGN015_MCF10A_48H:H18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01984
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.788547
nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.553456
disseminated intravascular coagulation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.167682
GSE223908,GSE223909_1_v_3_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112763,GSE112767_0_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:K22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17646
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.359752
blood cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.690451
GSE231891_5_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE214505_0_v_1_akr1b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
AD-51-FB60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201618
sw-1116 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.320591
CRCGN009_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4754
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
transferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.076814
hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04286
PML body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.125
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.280385
GSE202434,GSE202438_9_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE60217_1_v_2_inosine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE181821_1_v_4_mov10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HEXIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50815
GSE226316_3_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MC116	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.23659
CRCGN016_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8832
skin cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067904
BD-96-HO33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268991
GSE240027,GSE240030_5_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195503_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.35412
GSE205729,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
vascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.328628
Prostate Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
retinal cell cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.27083
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TK10	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.75687
lymphoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.077134
496100408_PCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.14074
GSE248045,GSE248046_6_v_2_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
3447_GNL3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.557389
Lymph	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
uterine disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.087808
GSE110524_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
lung cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.348148
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.439507
epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.12438
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	101.012
ALDH1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34437
internal male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.45567
CRCGN016_MCF10A.WT.HP_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24462
GSE180641_0_v_1_zfp503_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211286_1_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE176093_2_v_3_mineral oil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ovary	HPA Tissue Protein Expression Profiles	-1.0	-1.05229
CRCGN015_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.82827
CRCGN010_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.36245
urinary bladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.166995
GSE220520_5_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Avagacestat_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0256936
ED-81-ZH14_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.342956
FOS::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8181
intestinal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.470763
GSE93674_2_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
COX6A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28734
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
CRCGN014_HEPG2_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.77167
vascular smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.455284
GSE129186,GSE129223_0_v_1_aicda_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hypertrophic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.573828
nucleobase-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
COLO-783	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.07376
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216578
vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.172291
CRCGN015_MCF10A.TP53.M_24H:H21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0706
GSE110178_5_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Transcription factor TFIID complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.655
CRCGN012_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06179
ENDOU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05556
placenta	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071134
smooth muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.05229
6283_PHF19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.78232
GSE80446_0_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205550,GSE205552_2_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ht-29 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.720345
BxPC-3	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.83233
KA-75-LP02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.353898
8431_SRSF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.606247
CRCGN017_MCF10A.WT.HP_24H:I01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22486
CAL-27	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.54707
DJM-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.64655
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_S-Ruxolitinib_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145916
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.230931
CRCGN017_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.59821
GSE203308_6_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CDC23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33626
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.781894
CRCGN011_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.59615
mh1c1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.549312
cervicitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.315366
CRCGN015_MCF10A.TP53.M_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15135
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CCDC88C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9386
PMC9886955-41420_2023_1325_MOESM12_ESM.xlsx-H6_14AvsH6_NC-Unnamed_2_HMX1	Rummagene Transcription Factor Associations 2026	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.051505
liver cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.124376
sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.481259
CRCGN017_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.87035
HSP90AA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12443
GSE205963_0_v_1_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.02075
GSE185944_5_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nucleoside binding	GO Molecular Function Annotations 2015	1.0	null
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.364139
GSE178532_2_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NAMALWA	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.93234
leptospirosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.208579
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5921
GSE157233_1_v_4_a1cf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
binding	GO Molecular Function Annotations 2015	1.0	null
UWB1.289	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.77322
CRCGN017_MCF10A.WT.HP_24H:J04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.70628
atpase activity	GO Molecular Function Annotations 2015	1.0	null
purine ribonucleoside binding	GO Molecular Function Annotations 2015	1.0	null
pharynx	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.157326
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	121.896
CRCGN009_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.75014
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.745864
GSE131660_2_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8410861-41467_2021_25544_MOESM32_ESM.xlsx-MCR-MCR_cells_-_DGE_iGCA_testis_vs_adult_testis_from_GSE112013_and_GSE124263_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Paraspeckles	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.851
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-2_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8569
CRCGN011_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23455
4908_MCOLN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.755441
GSE185944_5_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Cajal body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.145
CRCGN011_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.06595
autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046459
GSE193334_1_v_0_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
bronchiolar epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.464561
GSE202434,GSE202438_2_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
embryonic fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.312595
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2588
GSE210655_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BCAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27404
CRCGN015_MCF10A_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.86062
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209645
Lyme Disease	DisGeNET Gene-Disease Associations	1.0	null
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.6929
CRCGN016_MCF10A.TP53.M_24H:D18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.74616
colonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.793126
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.87733
GSE240439_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210655_1_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Metabolism	Reactome Pathways 2024	1.0	null
CRCGN010_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.80667
gastric adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.3976
Mpp10 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.598
CRCGN016_MCF10A.WT.HP_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47568
throat	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059441
GSE202434,GSE202438_3_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
variable age at onset electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.163111
muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.310059
hcinap	GeneRIF Biological Term Annotations	1.0	null
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.67821
6611_PPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.857567
GSE240439_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CAMK2N1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4047
GSE171179,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE218060_7_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
lymphocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.357058
squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.092764
GSE202434,GSE202438_13_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
496100445_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.0258
Pwp2p-containing subcomplex of 90S preribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.664
CDK9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12592
GSE211286_7_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
embryonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.307889
GSE201042_6_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DD-74-PJ26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285097
cell part	GO Cellular Component Annotations 2015	1.0	null
PRRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35227
cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.170299
MS-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.81213
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	108.382
RPS10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14787
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051538
CRCGN013_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.76934
PMC12179407-MCO2-6-e70261-s004.xlsx-up_TET3-KO_PQ_vs_Cas9_PQ-Unnamed_10_TET3	Rummagene Transcription Factor Associations 2026	1.0	null
membrane	GO Cellular Component Annotations 2015	1.0	null
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.376467
GSE203308_14_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
colonic epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.244232
mcf-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.658678
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE163297_0_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IC-05-AW29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.280966
6032_PAF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.53737
Stress response complex	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.266069
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
GSE157594_0_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
other source	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.287803
GSE110440_1_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TBC1D22B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78295
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.336694
GSE178714_5_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.750818
496100395_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.15873
melanocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06817
GSE193751_1_v_3_oridonin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.12171
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.836995
OCI-AML2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.137
molecular_function	GO Molecular Function Annotations 2015	1.0	null
small intestine cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.576015
Cajal body	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Mrsa - Methicillin Resistant Staphylococcus Aureus Infection	DisGeNET Gene-Disease Associations	1.0	null
nucleotide kinase activity	GO Molecular Function Annotations 2015	1.0	null
biofilm	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.28213
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1092	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.4001
CRCGN015_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.50002
CRCGN015_MCF10A_48H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.60275
urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046953
immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040517
hepatoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.283545
PGAP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05546
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.615861
breast adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.646505
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.490229
CRCGN016_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3203
GSE94849_1_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.376064
phosphorylation	GO Biological Process Annotations 2015	1.0	null
GSE225218_0_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.02608
GSE123825_2_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cilengitide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.6
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-mouse_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
OSBPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09997
Acute Leukemia	DisGeNET Gene-Disease Associations	1.0	null
hep-3b cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.212761
small molecule binding	GO Molecular Function Annotations 2015	1.0	null
GSE239578_1_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	91.654
mcf-10a cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.408592
GSE234647_1_v_3_regorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Centrosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
496100374_HIP_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00569
4470_KRI1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.564592
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2661
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
pharyngeal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.213291
GSE185519_6_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE217541,GSE217543_3_v_1_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.59375
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nucleoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
colorectal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.788547
GSE137954_4_v_2_smyd3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.356
CRCGN015_MCF10A_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.12175
GSE202434,GSE202438_15_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYBL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15447
PAK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02268
GSE135352_0_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.2701
cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE202434,GSE202438_3_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE121198,GSE129779_0_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE199606_5_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE113106_0_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE241036_0_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.257237
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
GSE120370_4_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209537
GLI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05673
DYNLRB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03039
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
cardiofibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.260267
rectum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.187389
CRCGN009_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00901
CRCGN016_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32849
GSE250534_0_v_3_cabergoline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4785
CRCGN016_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.35453
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.297089
CRCGN008_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07925
PMC11046918-12967_2024_5211_MOESM4_ESM.xlsx-F_HT1080_FUS-DDIT3_regulated-Table_S2_Regulated_genes_between_scaffold-cultured_and_monolayer-cultured_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
purine ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
PDCD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55867
CRCGN015_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.90195
thrombophilia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.119826
pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.282483
9886_XAB2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.61201
organ system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040827
RPUSD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15339
2907_FAM216A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.504017
GSE164508_1_v_0_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.499501
PMC8948659-ADVS-9-2104491-s013.xlsx-Sheet1-Supplemental_Table_9_related_to_Figure_7_Differential_genes_highly_correlated_with_TP53_deletion_in_H929_cells_by_RNA-seq_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
uterus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
urethral disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.167682
SPRYD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14646
GSE128333_2_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE155305_2_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
placenta	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.356705
GSE186440,GSE186443_2_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.312
BRCA1-C complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.109
lymphoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070351
protein binding	GO Molecular Function Annotations 2015	1.0	null
prostate cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.59124
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.56545
nucleobase-containing compound kinase activity	GO Molecular Function Annotations 2025	1.0	null
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
lip	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.29175
trophoblast giant cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.260267
mouth	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.111117
ZBTB7C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.501
Adenylate kinase isoenzyme 6	InterPro Predicted Protein Domain Annotations	1.0	null
neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057526
GSE185519_3_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.051856
Cellular bud neck septin structure	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.61
GSE236437_2_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
141_ADAT3_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.507268
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Combined-MYB_Combined_sgRNA_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
496100478_HIP_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.89215
respiratory system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.50942
PMC9456253__F4	PFOCR Pathway Figure Associations 2024	1.0	null
immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.264077
follicular adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.176485
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
adult	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.429165
cell culture	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.28887
SMN complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.714
artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.287447
PUF60	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32551
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
sgc-7901 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.436822
DLX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14114
GSE217441,GSE217443_1_v_0_ivosidenib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE203158_0_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SMN-Sm protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.713
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.22388
GSE119564_2_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03693
bronchus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.097257
AN3-CA	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.80687
CRCGN014_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5257
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201331
CRCGN015_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.19895
FUBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31839
Frt	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.727
DNAJA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13556
GSE234340_1_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32467
CRCGN014_HEPG2_24H:J15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.017
GSE226316_0_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE234340_10_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7029
GSE198254_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-female_port-FOS_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
prostate gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.551298
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.291008
SOHLH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43151
breast	HPA Tissue Protein Expression Profiles	-1.0	-0.721523
GSE241036_4_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
4944_MED21_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.723636
Precatalytic spliceosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.611
GSE224877_3_v_0_pctp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE109913_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6535
gastric cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.167467
GSE234637_3_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	105.894
B-cell lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.694
metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE220520_6_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.45465
ZBTB7A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9059
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.439922
extracellular space	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.351762
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.910946
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.06774
COR-L311	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.93365
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.092
dysentery	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.207912
CRCGN015_MCF10A_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.70042
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.752085
GSE93309_2_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE141143_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Site of double-strand break	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.809
pancreatic carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.198709
nucleobase-containing small molecule interconversion	GO Biological Process Annotations 2025	1.0	null
CRCGN008_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.62855
nucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.715458
chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.165
PMC12079334-ADVS-12-2501734-s002.pdf-56-ENSG00000062194_GPBP1	Rummagene Transcription Factor Associations 2026	1.0	null
myeloid leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.402523
GTEx SmallIntestine 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	3.15126
GSE81193_0_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
preribosome, small subunit precursor	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.061
Nuclear body	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
FA-10-SN61_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222565
b-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068535
pancreatic cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.227445
liver	HPA Tissue Protein Expression Profiles	-1.0	-2.3516
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.1747
aorta	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.262986
bone marrow	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060127
colorectal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.78938
MI-3	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
BE-27-RQ61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214846
GSE202434,GSE202438_15_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
marrow cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.339282
pancreas adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.257005
bronchiole	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.180521
GSE185944_5_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2707_ERH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.523711
CRCGN012_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28372
GSE200839,GSE233826_3_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
LAMA-84	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.24916
GSE216757_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAZ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	109.171
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
cyclin d3-cdk4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.438146
ASPHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71554
coilininteracting	GeneRIF Biological Term Annotations	1.0	null
GSE179974_3_v_1_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064041
vascular smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.477756
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247324
oral cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.212936
GSE135244_0_v_1_trdmt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210885_2_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146894_3_v_8_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE185139_1_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE211983_0_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PDPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33809
cyclin d1-cdk6 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.633305
Small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.452
CRCGN008_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32695
GSE123638,GSE123639_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE179036_1_v_0_trim24_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-1.47274
acute lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.422673
colorectal adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.804796
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
Cholangiocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.878
CRCGN016_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.47759
Cataract	DisGeNET Gene-Disease Associations	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CAPZA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85253
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC8141032-NIHMS1694738-supplement-Supplementary_Table_1.xls-MYC_BAF155_BRG1-Unnamed_14_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE115542_5_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE157296,GSE157298_4_v_3_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
colorectum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.80271
CRCGN016_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.44311
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
cone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.749166
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211602
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
hepa 1-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.314046
CRCGN015_MCF10A.WT.HP_24H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15061
heart	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058861
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H2122 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.993
CRCGN017_MCF10A.WT.HP_24H:O08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4573
nucleomorph	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.563847
KYSE-520	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.72461
GSE48812_11_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Organelle envelope lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.184
GSE131887_1_v_4_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MRPL44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19148
adenyl nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
lymphoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.101523
FLO-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.18416
1177_CAPG_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.640794
CF-79-FU20_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274108
purine ribonucleoside triphosphate binding	GO Molecular Function Annotations 2015	1.0	null
GSE247862,GSE247863_4_v_3_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cervical cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
7194_RC3H1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.676852
CDK8_knockdown_129_GSE30816	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-3.12856
nuclear part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.23776
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.22518
squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.348981
8433_SRSF3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.506427
LU-99A	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.94461
du-145 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.549709
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1049
ATP binding	GO Molecular Function Annotations 2025	1.0	null
K562_Prednisone_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209331
EW-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.90709
nucleolus	GO Cellular Component Annotations 2015	1.0	null
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.66819
CRCGN008_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.623
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.133
small nucleolar ribonucleoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.232386
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.639289
GSE239578_0_v_4_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE134375_6_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE173873_10_v_6_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE255680_2_v_0_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
lymphoblastoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.106592
SYCE1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0205
GSE130676_0_v_2_suds3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7507_RPS18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.505503
Root apex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.139
CRCGN015_MCF10A_48H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16519
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
anion binding	GO Molecular Function Annotations 2015	1.0	null
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE88819_7_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OCI-AML3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.242
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45091
Microtubule organizing center	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.421148
Gametocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.847
hypopharyngeal carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.439507
GSE71529,GSE71558_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3284
seminal vesicle	HPA Tissue Protein Expression Profiles	-1.0	-2.3516
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
cyclin b1-cdk1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.433407
atp binding	GO Molecular Function Annotations 2015	1.0	null
extracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.702626
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.688576
schwann cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.239307
fadu cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.441042
GSE215351,GSE215794_4_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE215155_0_v_1_golph3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	103.813
GTEx AdiposeTissue 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-13.3501
transcript	GeneRIF Biological Term Annotations	1.0	null
pancreatic beta cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.234878
No annotation - 6	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.210589
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.592444
extracellular region	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.460001
PMC11373733-ABR-13-34_Suppl1.pdf-283-ZNF138_ZNF138	Rummagene Transcription Factor Associations 2026	1.0	null
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246669
GSE87617_1_v_0_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Glume	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.627
Microtubule cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
PMC8141032-NIHMS1694738-supplement-Supplementary_Table_1.xls-MYC_BAF155_BRG1-Unnamed_15_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE92364_0_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
7169_RBM28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.533646
SAT	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.05472
Lateral root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.853
heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.053707
GSE92589_0_v_1_sirolimus_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
OCI-M1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.28618
GSE201042_6_v_1_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
1040_C1ORF131_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.541276
L-Thyroxine (sodium salt pentahydrate)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0164843
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-6_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193900,GSE193905_1_v_0_pura_human	RummaGEO Gene Perturbation Signatures	1.0	null
CAPRIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12202
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.807299
Acute promyelocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.758
Heart Failure	DisGeNET Gene-Disease Associations	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.4057
GSE140322_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.893496
GSE166783_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE168602,GSE168604_2_v_6_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
organelle	GO Cellular Component Annotations 2015	1.0	null
SUP-T1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.85265
fetus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
496100555_TCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.23218
colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.319363
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.253645
GSE202284,GSE202289_12_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cellular nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
uterus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.290295
IKKalpha-IKKalpha complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.507
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE103068_0_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.2059
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.552888
GSE165647_2_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
nalm-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.229032
phosphotransferase activity, phosphate group as acceptor	GO Molecular Function Annotations 2015	1.0	null
CRCGN010_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45362
epilepsy syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.069587
organic cyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
small nuclear ribonucleoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.184241
syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.082173
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
large intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.726507
GSE153871_4_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4367834-12864_2014_6889_MOESM9_ESM.xlsx-Network_Parkinson_s_Disease-TBP_TBP	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3278
GSE139540_3_v_2_menadione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.31146
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110178_5_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NSMCE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03068
CRCGN013_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1203
cervix disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.277584
morula	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.091242
PEX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20545
GSE196104,GSE196106_3_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR	Rummagene Transcription Factor Associations 2026	1.0	null
melanoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.072091
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.3
small-subunit processome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.81
CRCGN016_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.62959
CRCGN017_MCF10A.WT.HP_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0563
Stable Angina	DisGeNET Gene-Disease Associations	1.0	null
GSE130396_1_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195503_3_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6818
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.42825
CRCGN017_MCF10A.WT.HP_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29825
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-9_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
globe disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.915551
ags cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.360782
myeloma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081669
GSE148200_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	100.292
cell type benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044878
DEL	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.01061
GSE135350_2_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2516
CRCGN012_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47242
RCOR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84375
UGT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07379
GSE249893_1_v_0_tfam_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.59319
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.89477
CRCGN014_HEPG2_3H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7372
CRCGN016_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4208
leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.525955
GSE180800,GSE180801_0_v_5_tex10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169356_0_v_5_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNU13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8138
iec-18 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.698216
GSE146840,GSE146842_3_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	1.0	null
cardiovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.464561
BHLHE22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18605
gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043669
Gefitinib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
496100339_HIP_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.41949
Thrombocythemia, Essential	DisGeNET Gene-Disease Associations	1.0	null
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.687618
PMC9634663-DataSheet10.xlsx-K562-MYC-AID_RNA-Seq_1326_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
7498_RPS10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.541578
GSE224877_2_v_1_pctp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE162739_2_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
5746_NOP14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.772286
GSE186471_1_v_2_carnosol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE220914_2_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE241402_0_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE125014_1_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149880_2_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135400_1_v_0_kdm1b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RCC10RGB	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.07852
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-E20_624_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ion binding	GO Molecular Function Annotations 2015	1.0	null
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
locus	GeneRIF Biological Term Annotations	1.0	null
GSE228181_2_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
P-loop containing nucleoside triphosphate hydrolase	InterPro Predicted Protein Domain Annotations	1.0	null
k-562 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.358919
GSE234340_9_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04907
non-small cell lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060931
peripheral nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071309
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210655_1_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
COPB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20196
GSE218879_1_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.050856
melanoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069627
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ABI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43415
skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.235748
GSE241036_0_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1663
CRCGN016_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16751
pharyngeal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.213112
GSE110178_5_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_proteinGroups-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
biliary epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.451428
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.434523
colonic adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.810638
ATN-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.00298
K562_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167508
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.571619
bone marrow cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06982
GSE217541,GSE217543_0_v_1_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:I08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05735
CRCGN015_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0855
TENT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17704
eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.915963
GSE112860_9_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152246_0_v_1_dihydrotestosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
embryonic fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.478534
CRCGN011_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13925
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A_48H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07938
musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042551
squamous epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.096214
flower	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.125692
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	80.0752
GJD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07678
ocular cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.2656
LENG8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29856
ALS2CL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71627
GSE231891_1_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149124,GSE149128_3_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
colonic epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.151574
CRCGN009_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0227
GSE202434,GSE202438_15_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.543176
FOSL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6719
HES5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.786
CRCGN009_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.85904
GSE142210_2_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
HACD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14097
GSE162739_7_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SCC-3	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.12331
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.715
CRCGN014_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.98947
adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.953409
GSE168676_2_v_3_dach1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
adult stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.584823
gametocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070365
GSE165689_0_v_1_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100457_TCx_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.44525
intracellular non-membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredPeptides-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
kinase activity	GO Molecular Function Annotations 2015	1.0	null
intestinal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.889253
thyroid epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.213291
nucleoplasm part	GO Cellular Component Annotations 2015	1.0	null
DCTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.84371
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN013_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.55389
CRCGN016_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.01362
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1549
CRCGN008_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.10245
CRCGN016_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.02876
GSE227891_2_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.7411
GSE184399_0_v_2_cnot1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CACNG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42746
Cellular bud neck septin ring	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.61
intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.05959
stomach	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.126127
cystadenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.215992
myeloid leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.122956
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
5659_NGDN_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.529704
GSE199606_5_v_4_csf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ovotestis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.636
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267232
GSE127790_10_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.049708
GSE119498_0_v_5_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Meprednisone_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171611
nuclear part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
prostate gland cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.587629
GSE182680,GSE182683_7_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cell plate	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.408699
GSE225218_2_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125403_7_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
BEN	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.32649
8594_SUPT16H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.738009
morris hepatoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.47348
KCNIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97976
GSE183251_4_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186005_1_v_2_klf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.588995
CRCGN013_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.78597
CRCGN017_MCF10A.TP53.M_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23045
purine nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7519_RPS28_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03478
K562_Divalproex Sodium_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195057
Ca-Ski	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.14246
GSE102505_4_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169356_0_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.566828
adenylate kinase activity	GO Molecular Function Annotations 2025	1.0	null
7424_RPAP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.62737
GSE149139_1_v_0_carm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SK-PN-DW	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.80248
genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.172799
Schizont	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.779
CRCGN017_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.86518
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211055
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
organism form	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
phosphotransferase activity, phosphate group as acceptor	GO Molecular Function Annotations 2025	1.0	null
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.964549
intracellular part	GO Cellular Component Annotations 2015	1.0	null
CRCGN017_MCF10A.WT.HP_24H:J14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31155
bronchoalveolar system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.364886
PXYLP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4079
Periderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.773
GSE94011_2_v_1_pias3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
thyroid adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.113223
GSE186620_0_v_1_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1147
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETV4_ETV4	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN012_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.53703
Glomerular Filtration Rate	DisGeNET Gene-Phenotype Associations	1.0	null
urethritis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.245747
encoded	GeneRIF Biological Term Annotations	1.0	null
ink gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.487691
TMED2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62243
structure	GeneRIF Biological Term Annotations	1.0	null
wolfram syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.333583
thyroid gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062394
GSE112860_0_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.50004
PMC11615365-41467_2024_54246_MOESM6_ESM.xlsx-KK47-Numb-KD_vs_Ctr-KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
FAM83G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12199
Root cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.659
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Purine metabolism	KEGG Pathways 2026	1.0	null
GSE103372_1_v_2_smad1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081131
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	138.629
AC-84-QG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.279723
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.6424
CRCGN010_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.756
PMC12575911-43556_2025_329_MOESM2_ESM.xlsx-SD2_MITF_CoBindingGenes-Gene_MITF	Rummagene Transcription Factor Associations 2026	1.0	null