association dataset threshold value standardized value SP in entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.83636 496100539_HIP_probable Alzheimer's disease_TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.02843 biological_process GO Biological Process Annotations 2015 1.0 null GATA2 ENCODE Transcription Factor Targets 1.0 null GFI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.8834 5747_NOP16_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.536711 inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.45994 2129_DDX54_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.815664 7467_RPL37A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.683826 polyol transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null Autoimmune disease of musculoskeletal system DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.031 SPI1-20517297-HL60-HUMAN ChEA Transcription Factor Targets 2022 1.0 null 4208_ISG20L2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.706286 8433_SRSF3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.68337 hsa-miR-4726-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 substrate-specific transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null Jejunal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.62 496100652_PCx_probable Alzheimer's disease_TBI_83_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.08546 medial subdivision of central nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.23743 GTEX-WZTO-0006-SM-3NM9T GTEx Tissue Sample Gene Expression Profiles 1.0 0.854425 4941_MED19_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.544589 FUS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56861 Transport of small molecules Reactome Pathways 2024 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.08283 KHSRP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98099 endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050867 Allergic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.027 SP in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.6086 Female reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.044 forestomach TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.196323 urea transmembrane transporter activity GO Molecular Function Annotations 2025 1.0 null MYC_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CP in caudal hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.82615 coronary artery disease GWASdb SNP-Disease Associations 1.0 0.608439 9820_WDR43_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.08127 GSE160304,GSE163392_7_v_3_zswim8_human RummaGEO Gene Perturbation Signatures 1.0 null ciliary body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.347038 HS821T CCLE Cell Line Gene Expression Profiles -1.0 -3.13166 9366_TSR2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.587676 structural GeneRIF Biological Term Annotations 1.0 null 496100349_HIP_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.64966 cortico-medial group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.00339 IRF1 ENCODE Transcription Factor Targets 1.0 null GTEX-WY7C-0006-SM-3NB3L GTEx Tissue Sample Gene Expression Profiles 1.0 1.7815 outer CP in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.04669 GTEX-PLZ6-0126-SM-48TC6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20582 SNU-423 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0863 BATF::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.7801 Ventral pallidus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.990224 rumen epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.95384 5735_NOL6_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.729042 urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.59124 Endocrine gland cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.135 Lung squamous cell carcinoma_LUSC_TCGA-85-7710-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1021 GTEX-Q2AI-0006-SM-2I3FG GTEx Tissue Sample Gene Expression Profiles 1.0 1.5034 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null GSE216273,GSE216292_0_v_1_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null NCI-H1703 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.846462 GTEX-REY6-0426-SM-2TF5G GTEx Tissue Sample Gene Expression Profiles 1.0 1.76287 MAFK JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.7477 GSE209582_1_v_2_chloroquine_human RummaGEO Drug Perturbation Signatures 1.0 null SWSAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87919 Nonpigmented ciliary epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.733 812_BCR_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.612024 RBM5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84485 Corneocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.79 superior rostral gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.846601 NB6 DepMap CRISPR Gene Dependency 1.0 2.23884 1961_CUL2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.522049 GTEX-XPT6-0006-SM-4B66Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.351 intracellular membrane-bounded organelle GO Cellular Component Annotations 2025 1.0 null GTEX-S4Q7-0426-SM-3K2BJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.16847 CTCF-27219007-CHIP-SEQ-ERYTHROID-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BCL6-27268052-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null urea transport GO Biological Process Annotations 2015 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EM-01A-21R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STAT3 ENCODE Transcription Factor Targets 1.0 null NFIB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.4769 H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null GATA2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.481 BICR78 DepMap CRISPR Gene Dependency 1.0 2.25446 CAOV-3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.592 496100533_TCx_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.15106 7516_RPS27A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.702685 response to toxic substance GO Biological Process Annotations 2015 1.0 null TM7SF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76846 8165_SMG1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.786823 PRR5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8664 ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE205163,GSE205164_2_v_8_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null H3K27me3_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WOFM-0005-SM-3MJF3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.75737 2791_EXOSC4_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.722523 SPEF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80881 COL9A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57669 gastrointestinal tract TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null 7509_RPS19_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.679995 medial group of nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.907468 regulation of biological quality GO Biological Process Annotations 2015 1.0 null channel activity GO Molecular Function Annotations 2015 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-5847-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1876 COSMIC Cell Line Gene CNV Profiles 1.0 2.3178 GTEX-XUYS-0005-SM-47JZ2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04671 GTEX-S4Q7-1226-SM-4AD5I GTEx Tissue Sample Gene Expression Profiles 1.0 0.900435 rostral group of intralaminar nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.847143 plasma membrane LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-S32W-1326-SM-4AD5Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.36187 ZSCAN29 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.427 CAL-12T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11805 Lung squamous cell carcinoma_LUSC_TCGA-77-8009-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U3ZN-0006-SM-3DB7Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.977271 BCL6-25482012-CML-JURL-MK1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CP in rostral hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15789 GTEX-RUSQ-0626-SM-2TF5V GTEx Tissue Sample Gene Expression Profiles 1.0 1.13213 paracentral lobule, posterior part, right, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.34963 GSE174701_4_v_7_maml3_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null urea transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null colorectal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.071061 PMC10274973-media-3.xlsx-ST18-Unnamed_9_ST18 Rummagene Transcription Factor Associations 2026 1.0 null TRPS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.033 9684_UTP20_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.646741 differential GeneRIF Biological Term Annotations 1.0 null HCC1428 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.747817 7500_RPS12_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.513284 NOB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9819 2113_DDX24_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.538588 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETS1_ETS1 Rummagene Transcription Factor Associations 2026 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FM-8000-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF770 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.2765 RARB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.0043 HMGB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.943 Lung squamous cell carcinoma_LUSC_TCGA-77-6842-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null basolateral plasma membrane GO Cellular Component Annotations 2023 1.0 null NCI-H2804 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06216 GTEX-T2YK-0005-SM-32QOV GTEx Tissue Sample Gene Expression Profiles 1.0 0.899531 Brain Lower Grade Glioma_LGG_TCGA-S9-A6WG-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AMO1 CCLE Cell Line Gene CNV Profiles 1.0 1.53497 KLHDC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.32471 Myoepithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.951 CTCF_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null epithelial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052778 9841_WDR75_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.01061 TMEM37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34728 Mesothelioma_MESO_TCGA-MQ-A4LJ-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAFK ENCODE Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JT-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1 ENCODE Transcription Factor Targets 1.0 null water channel activity GO Molecular Function Annotations 2025 1.0 null Exocrine acinar cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.255 POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q734-0626-SM-2I3EF GTEx Tissue Sample Gene Expression Profiles 1.0 0.948849 7527_RPS5_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.637549 TP63-23658742-EP156T-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null ulcerative colitis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.246098 GATA1_erythroblast_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMS20 CCLE Cell Line Gene CNV Profiles 1.0 1.8265 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null GSE144500_8_v_2_ventx_human RummaGEO Gene Perturbation Signatures 1.0 null PMC12276197-18_2025_5784_MOESM1_ESM.xlsx-Sup_Table_10-Supplementary_Table_10_ERK_targets_from_Unal_et_al_2017_mapped_to_human_orthologous_genes_from_KD_and_SC_hypernetworks_AR Rummagene Transcription Factor Associations 2026 1.0 null Edinger-Westphal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.10251 Rumen TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.165 Diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.414 GSE234289_5_v_2_rfx6_human RummaGEO Gene Perturbation Signatures -1.0 null Vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.118 anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08816 epithelial GeneRIF Biological Term Annotations 1.0 null SP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.881702 P63-26484246-CHIP-SEQ-KERATINOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CDX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37921 Lung TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 7169_RBM28_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.705608 Myocardial Infarction HuGE Navigator Gene-Phenotype Associations 1.0 null GSE178714_6_v_0_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null Brain edema DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.67 SKMEL31 CCLE Cell Line Gene CNV Profiles -1.0 -1.90205 7497_RPS10-NUDT3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.520557 POLDIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71959 mammillary body, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.85644 STAT5A ENCODE Transcription Factor Targets 1.0 null 3677_HEATR1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.937823 NCOR1-26117541-K562-HUMAN ChEA Transcription Factor Targets 2022 1.0 null UWB1289 DepMap CRISPR Gene Dependency 1.0 2.68728 Granular vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.359 external encapsulating structure COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.080855 GTEX-XV7Q-0005-SM-4BRWI GTEx Tissue Sample Gene Expression Profiles 1.0 0.869411 ELK4 JASPAR Predicted Transcription Factor Targets 1.0 null CTCF_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 20035825-TableS5a GeneSigDB Published Gene Signatures 1.0 null uterus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.069391 ventrolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.48068 Pinealocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.681 PRR15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24883 SNU1077 CCLE Cell Line Gene Expression Profiles -1.0 -1.78642 GTEX-OIZI-0005-SM-2XCED GTEx Tissue Sample Gene Expression Profiles 1.0 1.10198 GTEX-PW2O-1426-SM-48TCD GTEx Tissue Sample Gene Expression Profiles 1.0 1.00907 Choroid plexus epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.086 rostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.957871 intracellular membrane-bounded organelle GO Cellular Component Annotations 2023 1.0 null KMS-28PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.33387 EZH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21987 E2F6_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gastrointestinal tract TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 outer CP in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20676 Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41Q-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE128333_2_v_1_tcf4_human RummaGEO Gene Perturbation Signatures -1.0 null CHTF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76378 seminiferous epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.360036 Colon cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.04 inside GeneRIF Biological Term Annotations 1.0 null BATF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.9231 jejunum TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PMC10170086-41598_2023_34519_MOESM6_ESM.xlsx-Shee2-The_differentially_expressed_genes_between_the_BARX2_high_and_BARX2_low_group_of_LIHC_patients_BARX2 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU878 CCLE Cell Line Gene Expression Profiles 1.0 1.36425 Intercalated cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.317 cerebellar cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01561 GTEX-OHPL-0006-SM-3MJHB GTEx Tissue Sample Gene Expression Profiles 1.0 1.66365 ZDHHC21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1614 GTEX-UJHI-0006-SM-3DB8H GTEx Tissue Sample Gene Expression Profiles 1.0 0.965093 PMC3610249-1471-2164-14-184-S4.xls-miR-331-3p_targets-NR2E3_NR2E3 Rummagene Transcription Factor Associations 2026 1.0 null ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N5-A4RJ-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nephron TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.087452 GTEX-S32W-0326-SM-2XCBI GTEx Tissue Sample Gene Expression Profiles 1.0 1.14815 NRBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37288 TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null single-organism transport GO Biological Process Annotations 2015 1.0 null Type 2 diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.385 PMC8040704-jcav12p2673s2.xlsx-Up-regulated_genes_in_EBF1-Unnamed_5_EBF1 Rummagene Transcription Factor Associations 2026 1.0 null transporter activity GO Molecular Function Annotations 2015 1.0 null protomers GeneRIF Biological Term Annotations 1.0 null GTF2B ENCODE Transcription Factor Targets 1.0 null RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDST8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.877838 9443_TWISTNB_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.18059 insight GeneRIF Biological Term Annotations 1.0 null polyol transport GO Biological Process Annotations 2015 1.0 null HCC1806 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.02387 2988_FBL_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.01963 USF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Submucosal gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.268 GTEX-P44H-0006-SM-2XCFB GTEx Tissue Sample Gene Expression Profiles 1.0 1.00894 7441_RPL17_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.19173 ALKBH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00212 OPM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.987458 5738_NOL9_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.3042 hsa-miR-3928 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-S4Z8-0006-SM-3K2AQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.55565 represents GeneRIF Biological Term Annotations 1.0 null alitretinoin_homo sapiens_gpl6480_gse43090 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-68-A59J-01A-21R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cardiovascular Diseases HuGE Navigator Gene-Phenotype Associations 1.0 null lipid storage disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.206248 PMC9385264-NIHMS1828071-supplement-8.xlsx-AR-gene_symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null laterodorsal part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.993914 GTEX-VJWN-0005-SM-3GIKF GTEx Tissue Sample Gene Expression Profiles 1.0 0.919749 SUM 149PT Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1858 Lung squamous cell carcinoma_LUSC_TCGA-43-3394-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-R55C-0005-SM-3GAE9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.73882 Parkinson's disease progression (motor) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.530103 GTEX-S3XE-0006-SM-3K2AA GTEx Tissue Sample Gene Expression Profiles 1.0 2.84806 TFB1M CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12465 PKIA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32443 LU-165 COSMIC Cell Line Gene Mutation Profiles 1.0 null MAZ ENCODE Transcription Factor Targets 1.0 null organic hydroxy compound transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null Lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.112 GTEX-QDVJ-0005-SM-2TC5X GTEx Tissue Sample Gene Expression Profiles 1.0 1.33347 496100532_FWM_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.02167 inferior rostral gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.852388 SNU489 CCLE Cell Line Gene Expression Profiles -1.0 -2.05331 GSE185139_1_v_2_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PLZ5-0006-SM-2S1NZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.0258 POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SAP30 ENCODE Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5444-01A-02R-1514-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.264 dual GeneRIF Biological Term Annotations 1.0 null PMC7617064-EMS151900-supplement-Extended_Data_Figure_5_Source_Data.xlsx-CLC_D9_DEG-Logfold_change_threshold_1_0_CENPX Rummagene Transcription Factor Associations 2026 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2824-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SNMC-1026-SM-4DM7K GTEx Tissue Sample Gene Expression Profiles 1.0 0.852013 GTEX-QCQG-0006-SM-2S1OW GTEx Tissue Sample Gene Expression Profiles 1.0 1.90399 head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065299 Overnutrition DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.637 GTEX-P78B-0005-SM-2I5GM GTEx Tissue Sample Gene Expression Profiles 1.0 1.08167 integral component of membrane GO Cellular Component Annotations 2015 1.0 null CDIPT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71672 496100460_TCx_possible Alzheimer's disease_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.20379 HOXC9-25013753-NEUROBLASTOMA BE2-C-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null skeletal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.062796 chemical homeostasis GO Biological Process Annotations 2015 1.0 null GTEX-R55G-0006-SM-2TC6O GTEx Tissue Sample Gene Expression Profiles 1.0 0.924544 abnormality of the coronary arteries GWASdb SNP-Phenotype Associations 1.0 0.277658 7510_RPS20_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.56877 primary auditory cortex (core)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.869559 NINJ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87562 POLR2AphosphoS5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RSF complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.254 PMC7305081-10120_2020_1045_MOESM1_ESM.xlsx-Tab2-Mutation-MAF_MAF Rummagene Transcription Factor Associations 2026 1.0 null primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.93473 uniquely GeneRIF Biological Term Annotations 1.0 null epithelioma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051683 single-organism cellular process GO Biological Process Annotations 2015 1.0 null UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.830089 frontal pole, right, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.74911 ARTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01491 DCLRE1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81953 BHLHE40_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A468-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null kidney TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.477367 Gastric juice TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.86 7481_RPL9_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.692322 CARMIL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05381 intrinsic component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.1183 Pericanalicular vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.1 Apical plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 COLO-824 COSMIC Cell Line Gene CNV Profiles 1.0 2.3178 pharmacogenomic GAD High Level Gene-Disease Associations 1.0 0.293278 IRF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Viral gastritis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.024 intestinal tuberculosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.52468 internal female genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056412 blood vessel TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.062231 GTEX-OIZI-0126-SM-3NB13 GTEx Tissue Sample Gene Expression Profiles 1.0 0.920227 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of the cardiovascular system GWASdb SNP-Phenotype Associations 1.0 0.069391 smallintestine_4a HPA Tissue Sample Gene Expression Profiles 1.0 2.3371 KP363T DepMap CRISPR Gene Dependency 1.0 2.46047 C2CD2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51731 SP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.843392 Lung squamous cell carcinoma_LUSC_TCGA-90-A4ED-01A-31R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A74H-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sublingual gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.768 primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.08116 CTCF_cardiac muscle cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2841-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SLC39A14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64556 Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SR-01A-12R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-6978-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TRIM28_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-96-A4JL-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SULT1A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11071 HCFC1 ENCODE Transcription Factor Targets 1.0 null MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null membrane LOCATE Curated Protein Localization Annotations 1.0 null MNT-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.577 Intracellular canaliculus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.193 polysensory temporal cortex (area 22p) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.863835 STAT6 MotifMap Predicted Transcription Factor Targets 1.0 null GSE178714_5_v_0_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null jejunum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.724453 occipital pole, left, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02671 lung GTEx Tissue Gene Expression Profiles 1.0 0.850454 hsa-miR-3154 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 PMC11993713-41598_2025_96655_MOESM1_ESM.xlsx-S10-Table_S10_MR_results_of_the_discovery_blood_cis-eQTLs_and_Sepsis_outcomes_in_IVW_or_Wald_ratio_methods_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null posterior orbital gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.53318 KASUMI1 DepMap CRISPR Gene Dependency 1.0 3.19874 capillary GeneRIF Biological Term Annotations 1.0 null Stroke HuGE Navigator Gene-Phenotype Associations 1.0 null NCIH2126 DepMap CRISPR Gene Dependency 1.0 2.25007 posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.880732 male reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055647 EFE184 DepMap CRISPR Gene Dependency 1.0 2.91857 glycerol transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null parabigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.875 Cholangiocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.004 DON cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.574 Integumentary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.351 hsa-miR-409-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 H3K27me3_mononuclear cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAL 54 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.983081 POLR2A_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-5055-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null endothelium GeneRIF Biological Term Annotations 1.0 null CAL-120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.77873 SARS-CoV_0Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.16118 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_y_CENPX Rummagene Transcription Factor Associations 2026 1.0 null 5089_NIFK_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.884216 Dermatitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.179 TSC22D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54937 GTEX-UJMC-0005-SM-3GACU GTEx Tissue Sample Gene Expression Profiles 1.0 1.49301 TMEM74B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7395 CLCN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72177 POLR2A_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null SKMEL19 DepMap CRISPR Gene Dependency 1.0 2.68393 cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.326829 CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1 ENCODE Transcription Factor Targets 1.0 null substrate-specific channel activity GO Molecular Function Annotations 2015 1.0 null Molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.04 area postrema Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19033 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-38-4626-11A-01R-1758-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NUAK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60304 H3K27me3_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPK-0006-SM-2HMKH GTEx Tissue Sample Gene Expression Profiles 1.0 1.309 Chloroplast ATP synthase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.508 help GeneRIF Biological Term Annotations 1.0 null A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc_3Hour_None_GSE43204 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.54546 Autoimmune disease of skin and connective tissue DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.073 ZNF189 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.882 glycerol transmembrane transport GO Biological Process Annotations 2025 1.0 null HOXC9-25013753-NEUROBLASTOMA-BE2-C-HUMAN ChEA Transcription Factor Targets 2022 1.0 null 7431_RPL10A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.54025 DIS3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50492 RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Apical part of cell COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 SG in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15204 7503_RPS15A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.823388 GTEX-RWSA-2426-SM-47JXR GTEx Tissue Sample Gene Expression Profiles 1.0 0.94649 NCI-H929 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.59592 GTEX-RWSA-0005-SM-2XCAO GTEx Tissue Sample Gene Expression Profiles 1.0 0.847095 OVCAR-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.826074 Renal papilla TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.538 POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE178714_1_v_2_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null presence GeneRIF Biological Term Annotations 1.0 null MM253 DepMap CRISPR Gene Dependency 1.0 2.09642 ONS76 CCLE Cell Line Gene Expression Profiles 1.0 1.84722 GTEX-QCQG-0326-SM-2I3ES GTEx Tissue Sample Gene Expression Profiles 1.0 0.860614 GTEX-XMK1-0126-SM-4B65F GTEx Tissue Sample Gene Expression Profiles 1.0 1.07312 KYO1 CCLE Cell Line Gene Expression Profiles 1.0 3.40802 Passive transport by Aquaporins Reactome Pathways 2014 1.0 null submandibular gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.213112 LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null SNN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34111 GSE216273,GSE216292_14_v_7_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-A6W5-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null paraventricular nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.96144 amide transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MEF2A_MEF2A Rummagene Transcription Factor Associations 2026 1.0 null Jejunum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.735 anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.18376 CTCF_Caco-2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7504_RPS15_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.951086 H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7454_RPL27A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.735452 NCI-H1437 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.48268 TM7SF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76279 PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Unnamed_12_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null primary auditory cortex (core)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.05086 Kidney Diseases CTD Gene-Disease Associations 1.0 1.02858 KIJK DepMap CRISPR Gene Dependency 1.0 2.96431 SUM225CWN Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.661315 CRIM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50897 KDM1A ENCODE Transcription Factor Targets 1.0 null CHD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68981 H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Aquaporin 10 InterPro Predicted Protein Domain Annotations 1.0 null MAFA MotifMap Predicted Transcription Factor Targets 1.0 null RCOR1 ENCODE Transcription Factor Targets 1.0 null CMK CCLE Cell Line Gene Expression Profiles 1.0 1.71014 CEBPD_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Digestive juice TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.029 Lung squamous cell carcinoma_LUSC_TCGA-22-A5C4-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ileum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.261624 hsa-miR-1205 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null 7512_RPS23_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.670601 Nutrition disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.637 HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.46147 LRR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2517 7444_RPL19_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.764963 RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null glycerol transmembrane transporter activity GO Molecular Function Annotations 2023 1.0 null precuneus, left, inferior lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.919214 duodenum HPA Tissue Gene Expression Profiles 1.0 1.5479 Myoepithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.909 TTC549 DepMap CRISPR Gene Dependency 1.0 3.45719 Aquaporin-mediated transport Reactome Pathways 2024 1.0 null Steatotic liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.109 inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.048223 carcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053436 SMAD2/3-21741376-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null HDAC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08096 Lung adenocarcinoma_LUAD_TCGA-93-A4JO-01A-21R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null protein tetramerization GO Biological Process Annotations 2023 1.0 null OCIM1 CCLE Cell Line Gene Expression Profiles 1.0 2.0557 medial portion of STH Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.951989 HTK CCLE Cell Line Gene CNV Profiles 1.0 1.51064 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A23L-01A-11R-A16R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.915417 doxycycline_mus musculus_gpl2872_gse33875 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 7459_RPL31_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.844513 H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null Perturb_12613_KD_SON_SRP278179 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 low GeneRIF Biological Term Annotations 1.0 null remaining GeneRIF Biological Term Annotations 1.0 null HCC1187 DepMap CRISPR Gene Dependency 1.0 2.07881 cellular water homeostasis GO Biological Process Annotations 2015 1.0 null B800-850 antenna complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.683 EKVX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.55572 mouth TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.072826 H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Connective tissue disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 H3K27me3_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-VP-A872-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cheek TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.309697 GSE164505,GSE164506_3_v_1_indisulam_human RummaGEO Drug Perturbation Signatures -1.0 null RPS6KA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02518 ARL6IP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53387 hsa-miR-4667-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 humans GeneRIF Biological Term Annotations 1.0 null Rectal gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.238 GSE131649_6_v_10_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null glycerol channel activity GO Molecular Function Annotations 2023 1.0 null Attention deficit hyperactivity disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TV-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KAT6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59639 Orthogonal array COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.673 ZBTB12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.3759 sweat gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.350372 4950_MED27_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.01233 GATA1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12148 H3K27me3_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2073 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19567 Apical cytoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.611 facial motor nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.08544 TUBA1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40287 Diarrhea DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.619 KDM5B ENCODE Transcription Factor Targets 1.0 null acid GeneRIF Biological Term Annotations 1.0 null 7449_RPL23A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.644371 HCT-15 COSMIC Cell Line Gene Mutation Profiles 1.0 null Capillary endothelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.626 UBTF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXE1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 56.8908 membrane part GO Cellular Component Annotations 2015 1.0 null Renal tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.817 Optic nerve disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.18 DHX36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56982 amygdaloid complex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.954971 USF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBED-0006-SM-47JXO GTEx Tissue Sample Gene Expression Profiles 1.0 1.41606 posterior group of nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.30888 GTEX-WCDI-0005-SM-3NB2M GTEx Tissue Sample Gene Expression Profiles 1.0 1.66471 gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.424581 Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EC-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A1QS-01A-61R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null temporal pole, right, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02805 hsa-miR-339-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GTEX-RWS6-0005-SM-2XCAN GTEx Tissue Sample Gene Expression Profiles 1.0 1.3884 deep layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00084 glycosylated GeneRIF Biological Term Annotations 1.0 null Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.545 Rumen epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.57 gametocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.128173 KMS-28BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.38224 MRPL53 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50691 RBBP5 ENCODE Transcription Factor Targets 1.0 null UM-UC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.865835 Gill TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.45 duodenum_4b HPA Tissue Sample Gene Expression Profiles 1.0 1.70457 SKMG1 DepMap CRISPR Gene Dependency 1.0 2.51497 Liver carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.019 NCIH2066 CCLE Cell Line Gene Expression Profiles 1.0 1.65981 CCNT2 ENCODE Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6021-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Mean corpuscular hemoglobin GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.3699 BFTC-909 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0863 8658_TAF1C_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.511772 Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A6SH-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Stomach disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.174 GTEX-O5YT-2126-SM-3MJGD GTEx Tissue Sample Gene Expression Profiles 1.0 1.15853 layer III of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.81171 H3K4me1_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_cardiac muscle cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10787250-BLOODA_ADV-2022-008899-mmc1.xlsx-Table_S7-Table_S7_Differentially_expressed_genes_commonly_up-_or_downregulated_in_CBFA2T3_GLIS2_leukemia_GLIS2 Rummagene Transcription Factor Associations 2026 1.0 null MGA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.0071 GTEX-R55D-0006-SM-3GIJS GTEx Tissue Sample Gene Expression Profiles 1.0 1.61115 Apical junction complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.382 GTEX-RM2N-0426-SM-2TF4T GTEx Tissue Sample Gene Expression Profiles 1.0 1.08257 TAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Basal part of cell COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 irritable bowel syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.60264 GTEX-O5YW-0526-SM-2YUMX GTEx Tissue Sample Gene Expression Profiles 1.0 0.87705 Reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.045 5550_NDUFAF7_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.503498 H3K9ac_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null oocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.755364 syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.066186 TAB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08256 Contractile vacuole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.708 DU4475 DepMap CRISPR Gene Dependency 1.0 4.47048 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4882-01A-02R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-R3RS-0005-SM-3GAEH GTEx Tissue Sample Gene Expression Profiles 1.0 1.06297 SG in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.31695 REST_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PHF8-20622854-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_x_CENPX Rummagene Transcription Factor Associations 2026 1.0 null posteroventral (inferior) parietal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.998725 disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.032646 superior parietal lobule, left, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.834551 pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.935979 glycocalyx COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.390455 GTEX-VJYA-0126-SM-4KL1P GTEx Tissue Sample Gene Expression Profiles 1.0 1.09153 RAD21 ENCODE Transcription Factor Targets 1.0 null GTEX-OXRL-0526-SM-2I3EZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.44916 GTEX-SE5C-0006-SM-4BRW5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.9977 Autoimmune disease of gastrointestinal tract DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.146 BCL11B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15988 operation GeneRIF Biological Term Annotations 1.0 null protein tetramerization GO Biological Process Annotations 2025 1.0 null Left colon TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.998 dorsolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.63063 H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Obesity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.638 cerebellar cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.2855 PLCPRF5 DepMap CRISPR Gene Dependency 1.0 2.23816 RUNX1-22343733-KASUMI1-HUMAN-PERIPHBLOOD-AML ChEA Transcription Factor Targets 2022 1.0 null GSE171837_1_v_2_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null 7479_RPL7_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.665947 H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Malignant Neoplasm DisGeNET Gene-Disease Associations 1.0 null PEA1 DepMap CRISPR Gene Dependency 1.0 2.7915 Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A67D-01A-31R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FXN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68721 molecular layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.49097 GTEX-X4EO-0006-SM-3P5ZF GTEx Tissue Sample Gene Expression Profiles 1.0 1.07373 Hg2+ Guide to Pharmacology Chemical Ligands of Receptors 1.0 null Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.802 PMC11848109-mmc6.xlsx-Genes_-150kbp_of_MR_sig_SNP-Unnamed_4_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null urinary system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.469599 villi GeneRIF Biological Term Annotations 1.0 null SIN3A ENCODE Transcription Factor Targets 1.0 null salivary gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.073242 SP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04532 GTEX-P4PP-0526-SM-2HMKE GTEx Tissue Sample Gene Expression Profiles 1.0 1.53218 FU97 CCLE Cell Line Gene Expression Profiles 1.0 2.25277 VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.62781 Apical complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.023 7451_RPL24_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.561645 RPMI-7951 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.877838 GSE205163,GSE205164_1_v_8_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-98-A53I-01A-31R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-1248 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GSE80819_0_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null 1301_CCDC86_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.710571 GSE150055_0_v_2_melphalan_human RummaGEO Drug Perturbation Signatures 1.0 null BATF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.6986 Viscus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 DYNC2I1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55305 colorectal cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.071672 HSDL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56883 8826_TEX10_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.508064 ventrolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 3.4231 Urinary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.423 Autoimmune disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.44 GTEX-Y8E5-0006-SM-47JWQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.04736 KELLY CCLE Cell Line Gene Expression Profiles 1.0 1.75432 GTEX-X15G-0005-SM-3NMDA GTEx Tissue Sample Gene Expression Profiles 1.0 1.51794 NCI-H345 COSMIC Cell Line Gene CNV Profiles 1.0 2.3178 GTEX-WHWD-0005-SM-3LK7D GTEx Tissue Sample Gene Expression Profiles 1.0 1.42484 HCC202 DepMap CRISPR Gene Dependency 1.0 2.10812 GSE262134_0_v_1_dnajc12_human RummaGEO Gene Perturbation Signatures -1.0 null EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null each GeneRIF Biological Term Annotations 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.54542 TE-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.3178 SUM 229PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.983081 5702_NLE1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.533166 posteroventral (inferior) parietal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08918 POLR2A ENCODE Transcription Factor Targets 1.0 null 19139136-TableS3 GeneSigDB Published Gene Signatures 1.0 null CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RVPV-0006-SM-2TF6Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.87257 anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.986005 OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02419 Lung adenocarcinoma_LUAD_TCGA-55-6970-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tongue epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.407832 GTEX-TML8-0005-SM-32QPA GTEx Tissue Sample Gene Expression Profiles 1.0 1.74788 H3K27me3_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7515_RPS26_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.06793 GTEX-VUSG-0006-SM-3GIK9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.55821 H3K4me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NCI-H1568 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26584 6533_POLR1A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.681758 transient Purkinje cell clusters Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.24917 PMC9287735-mmc8.xlsx-MI_Related_Genes-TNF_MITF Rummagene Transcription Factor Associations 2026 1.0 null 7508_RPS19BP1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.581167 SNTA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99942 H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.07 Cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.147 MDAMB453 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.82361 Polycystic kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.043 ventrolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.89002 Arsenic CTD Gene-Chemical Interactions 1.0 null GATA3 ENCODE Transcription Factor Targets 1.0 null 7432_RPL10_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.69363 secretory cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.2779 ESR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.0405 Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T5-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 5900_NUP62_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.520505 RAB11B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40808 adrenal gland GTEx Tissue Gene Expression Profiles -1.0 -1.12784 PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-KLF1_mod_KLF1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OHPM-0006-SM-2HMKU GTEx Tissue Sample Gene Expression Profiles 1.0 1.21073 Lung adenocarcinoma_LUAD_TCGA-38-A44F-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53 Rummagene Transcription Factor Associations 2026 1.0 null Lungfirst TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.65 Uterine fluid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.665 JAM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02177 dorsolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.49734 CEBPB_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WQUQ-0006-SM-3MJF4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.16527 GTEX-RN64-2326-SM-48FDW GTEx Tissue Sample Gene Expression Profiles 1.0 0.992173 anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.97674 cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null dorsomedial hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.18678 functionally GeneRIF Biological Term Annotations 1.0 null NCIH1395 CCLE Cell Line Gene CNV Profiles 1.0 2.69365 H3K27me3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PHF19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63966 EW22 DepMap CRISPR Gene Dependency 1.0 2.03117 GSE178714_1_v_7_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null respiratory system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05651 Hepatobiliary disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.32 Rectum adenocarcinoma_READ_TCGA-DT-5265-01A-21R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Collecting duct cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.743 TFE3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.1826 Breast Carcinoma DisGeNET Gene-Disease Associations 1.0 null CTBP1-25329375-LNCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null 7539_RPS9_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.622603 GTEX-S4UY-0006-SM-3K2A7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.98446 SNU216 CCLE Cell Line Gene Expression Profiles 1.0 1.41315 KARPAS-45 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-Q2AH-0005-SM-33HBR GTEx Tissue Sample Gene Expression Profiles 1.0 1.00727 JUN_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.711 GTEX-R55D-0926-SM-3GAEU GTEx Tissue Sample Gene Expression Profiles 1.0 0.926755 GTEX-XAJ8-0006-SM-46MVM GTEx Tissue Sample Gene Expression Profiles 1.0 1.29027 GTEX-WYJK-0005-SM-3NMA1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.871054 GTEX-TSE9-0005-SM-4DXUF GTEx Tissue Sample Gene Expression Profiles 1.0 1.72412 PANC 08.13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05083 outer SZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02864 pontine raphe nucleus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01558 GTEX-P4QT-0526-SM-2I3EX GTEx Tissue Sample Gene Expression Profiles 1.0 1.34209 ZBTB7A ENCODE Transcription Factor Targets 1.0 null Jejunum TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CBX3_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE162892_4_v_0_isox_human RummaGEO Drug Perturbation Signatures -1.0 null SP in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.846938 gill TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.751231 SMARCE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40559 posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.32773 GSE195559_8_v_1_notch1_human RummaGEO Gene Perturbation Signatures 1.0 null Bone inflammation disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 amygdaloid complex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.910815 into GeneRIF Biological Term Annotations 1.0 null GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.996611 Autoimmune disease of peripheral nervous system DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.397 midline nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.11545 HS 69ST Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19339 SNU81 DepMap CRISPR Gene Dependency 1.0 2.05704 APELA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35762 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8317-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ONECUT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.6937 KDM3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19628 GATA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.8081 HCC1937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.984185 GTEX-X585-0005-SM-46MV3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.854815 Perturb_10151_KO_SCR_SRP251223 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.90413 7501_RPS13_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.841028 NFKB1_01_167 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 8.83249 water transport GO Biological Process Annotations 2023 1.0 null CTCF_fibroblast of the aortic adventitia_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WHPG-1426-SM-3NMBB GTEx Tissue Sample Gene Expression Profiles 1.0 1.0091 H3K27me3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null integral component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.151674 GTEX-PLZ4-0006-SM-2S1NY GTEx Tissue Sample Gene Expression Profiles 1.0 0.949257 MCL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01003 GSE195559_6_v_1_notch1_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CBX3 ENCODE Transcription Factor Targets 1.0 null NR2F2 ENCODE Transcription Factor Targets 1.0 null BHY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.50519 RGS19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85705 SP in perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.24512 RERFGC1B CCLE Cell Line Gene Expression Profiles 1.0 1.52872 Hepatobiliary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.051 EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PSMC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10003 NCIH1876 CCLE Cell Line Gene CNV Profiles 1.0 2.16182 H3K27me3_H7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null transport GeneRIF Biological Term Annotations 1.0 null GTEX-U3ZM-0426-SM-3DB73 GTEx Tissue Sample Gene Expression Profiles 1.0 0.965081 7522_RPS2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.881232 head of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.823967 GTEX-QV31-0126-SM-447BP GTEx Tissue Sample Gene Expression Profiles 1.0 1.21718 MOLM13 DepMap CRISPR Gene Dependency 1.0 2.92272 Perivascular astrocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.139 Basal plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.415 GTEX-VUSH-0005-SM-3NB2H GTEx Tissue Sample Gene Expression Profiles 1.0 1.34714 GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles 1.0 2.07804 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43Y-01A-21R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ADGRB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47199 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IK-01A-32R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02436 viscus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null RCM-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null HCC1599 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.837826 CTCF_BE2C_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null T24 DepMap CRISPR Gene Dependency 1.0 2.76164 Mucous gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.404 NCI-H345 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.91338 CTCF_epithelial cell of esophagus_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Glucose metabolism disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.429 ZNF282 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64137 bladder TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.338177 posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.82997 Water HMDB Metabolites of Enzymes 1.0 null ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.98621 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.564 NCI-H2110 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.96657 GTEX-QLQ7-0005-SM-2S1QP GTEx Tissue Sample Gene Expression Profiles 1.0 1.81451 ELF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.0399 1470_CEBPZ_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.675418 ventrolateral prefrontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.834937 BHY CCLE Cell Line Gene CNV Profiles -1.0 -1.38565 P300-27268052-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null brain HPA Tissue Gene Expression Profiles -1.0 -1.06394 NCI-H1623 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.70998 DROSHA_02_01 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.05889 GATA1_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4QS-0526-SM-2I3ET GTEx Tissue Sample Gene Expression Profiles 1.0 0.959728 enhanced GeneRIF Biological Term Annotations 1.0 null intrinsic component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.135244 paracentral lobule, posterior part, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.44482 RCN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20589 GSE178714_1_v_0_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null Kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.398 Major intrinsic protein InterPro Predicted Protein Domain Annotations 1.0 null COLO800 DepMap CRISPR Gene Dependency 1.0 2.2792 cuneiform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2504 NOS-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.3178 HUH7 CCLE Cell Line Gene Expression Profiles 1.0 1.82429 GTEX-N7MS-0007-SM-2D7W1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.14168 MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04809 PMC9306206-12915_2022_1367_MOESM6_ESM.xlsx-Table_S7_-_JIP-Gene_SMAD4 Rummagene Transcription Factor Associations 2026 1.0 null PACS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40676 NCIH23 CCLE Cell Line Gene CNV Profiles 1.0 1.34502 Henles loop TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.974 diabetes insipidus DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.666755 Sperm flagellum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.883 ZNF384 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 116.279 GSE131649_6_v_8_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null COLO-800 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE201309_1_v_0_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null Thoracic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.143 PCDHGC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49595 Perturb_13686_KD_LDB1_SRP398635 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 dexamethasone_homo sapiens_gpl6244_gse20963 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XPVG-1026-SM-4B64Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.846414 Brain Lower Grade Glioma_LGG_TCGA-DU-8165-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EGR1 ENCODE Transcription Factor Targets 1.0 null ETFRF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8002 7437_RPL13_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.712042 Vaginal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.617 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7089-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IRAK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51212 TUBA1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92201 Diamine N-acetyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.826 GSE195559_0_v_9_notch1_human RummaGEO Gene Perturbation Signatures 1.0 null HEL CCLE Cell Line Gene Expression Profiles 1.0 2.50718 DU-145 COSMIC Cell Line Gene Mutation Profiles 1.0 null ORMDL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43218 Sperm flagellum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.005 Lung squamous cell carcinoma_LUSC_TCGA-66-2790-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6326-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null G61 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18469 GSE162892_4_v_5_isox_human RummaGEO Drug Perturbation Signatures -1.0 null HEL9217 CCLE Cell Line Gene Expression Profiles 1.0 2.51063 Tanycyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.559 organelle LOCATE Predicted Protein Localization Annotations 1.0 null primary visual cortex (striate cortex, area V1/17)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.966434 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7236-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Inflammatory bowel disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.226 Stomach cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.131 H3K27me3_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Exocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.829 9174_TOP1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.62938 Alzheimer Disease HuGE Navigator Gene-Phenotype Associations 1.0 null outer CP in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.843818 adipocyte GeneRIF Biological Term Annotations 1.0 null sufficient GeneRIF Biological Term Annotations 1.0 null YMB1 CCLE Cell Line Gene CNV Profiles 1.0 1.67908 Cardiac stomach TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.625 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A6MF-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.11171 medial preoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.858371 Immune system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 HEY2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.6185 CHST6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53428 plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.618406 GSE160304,GSE163392_4_v_3_zswim8_human RummaGEO Gene Perturbation Signatures 1.0 null Colonic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.027 lung TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Brain Lower Grade Glioma_LGG_TCGA-P5-A5EX-01A-12R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 6605_PPAN_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.5289 VDAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10976 GTEX-UPIC-0005-SM-3GACV GTEx Tissue Sample Gene Expression Profiles 1.0 1.30712 cuneate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.909544 Bone disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 7427_RPF2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.600663 dorsal lateral geniculate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.09532 inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.25795 glycerol GeneRIF Biological Term Annotations 1.0 null TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X5EB-0426-SM-46MVY GTEx Tissue Sample Gene Expression Profiles 1.0 0.998224 ZFYVE26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.452 ion transmembrane transport GO Biological Process Annotations 2015 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7423-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 7462_RPL35A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.621284 TAL1 ENCODE Transcription Factor Targets 1.0 null EBC1 CCLE Cell Line Gene CNV Profiles -1.0 -1.63996 GABPA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 10040_ZCCHC9_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.763684 Passive transport by Aquaporins Reactome Pathways 2024 1.0 null organic substance transport GO Biological Process Annotations 2015 1.0 null Connective tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.033 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7871-01A-11R-2232-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.8278 GTEX-VJYA-0926-SM-4KL1N GTEx Tissue Sample Gene Expression Profiles 1.0 2.52007 PRKD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3264 Ileal mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.19 NRN1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66505 seminiferous tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.15776 maintenance GeneRIF Biological Term Annotations 1.0 null RBPJ-21746931-IB4-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-VJYA-0326-SM-3GAEX GTEx Tissue Sample Gene Expression Profiles 1.0 1.06585 HCV JFH-1_18Hour_20200238_GSE20948 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.65329 glycerol channel activity GO Molecular Function Annotations 2015 1.0 null Gastric pit TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.891 Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.495 cell periphery COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 TRIM28 ENCODE Transcription Factor Targets 1.0 null water transport GO Biological Process Annotations 2015 1.0 null SK-MEL-31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.61427 colorectum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057973 RB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40629 MXI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF532 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68862 ELK1 ENCODE Transcription Factor Targets 1.0 null cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 NFYB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bothnian type palmoplantar keratoderma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.211 testis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.078397 intestine TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Vaginal smooth muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.615 4108_IMP4_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.761843 GSE131649_4_v_11_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47V-01A-11R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-CA-geneName_PTF1A Rummagene Transcription Factor Associations 2026 1.0 null Apical plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.787 GTEX-WFON-0005-SM-3NMC9 GTEx Tissue Sample Gene Expression Profiles 1.0 2.0626 RABL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00363 HDAC2 ENCODE Transcription Factor Targets 1.0 null Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane region COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.120717 NCI-H810 COSMIC Cell Line Gene CNV Profiles 1.0 2.3178 tear TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.58322 within GeneRIF Biological Term Annotations 1.0 null Sporoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.23 fallopiantube_5a HPA Tissue Sample Gene Expression Profiles 1.0 0.977876 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null FOXD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 74.3711 GTEX-XLM4-0005-SM-4AT4P GTEx Tissue Sample Gene Expression Profiles 1.0 0.974218 stratum basale TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.360409 Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null E2F6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null stratum corneum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.665995 EBNA2-21746931-IB4-LCL-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A85H-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 2731_ESF1_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.709163 6152_PDCD11_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.999843 CHD1 ENCODE Transcription Factor Targets 1.0 null MADD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20274 Lung squamous cell carcinoma_LUSC_TCGA-60-2722-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01305 cellular_component GO Cellular Component Annotations 2015 1.0 null FOXL1 JASPAR Predicted Transcription Factor Targets 1.0 null membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.61883 Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3471-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TP73 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.498 GATA2-19941826-K562-human ChEA Transcription Factor Binding Site Profiles 1.0 null Transmembrane transport of small molecules Reactome Pathways 2014 1.0 null H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE205163,GSE205164_2_v_0_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null FLI1::DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.8502 Glycerol CTD Gene-Chemical Interactions 1.0 null GSE158632_2_v_5_oxyquinoline_human RummaGEO Drug Perturbation Signatures 1.0 null Capillary endothelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.914 Contractile vacuole complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.593 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NH-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JUN ENCODE Transcription Factor Targets 1.0 null coronary disease; coronary heart disease; myocardial infarction GAD Gene-Disease Associations 1.0 null ZBTB49 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58739 NCI-H292 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-VJYA-0005-SM-3P5ZD GTEx Tissue Sample Gene Expression Profiles 1.0 1.74849 SOX2-21211035-LN229-HUMAN ChEA Transcription Factor Targets 2022 1.0 null cochlear nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.04906 MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.37198 SK-N-AS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.864901 GSE162892_4_v_2_isox_human RummaGEO Drug Perturbation Signatures -1.0 null NFYB ENCODE Transcription Factor Targets 1.0 null GTEX-PWO3-0005-SM-2I5FS GTEx Tissue Sample Gene Expression Profiles 1.0 0.878814 exocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.325335 Serum total protein levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.830103 Acute Myeloid Leukemia_LAML_TCGA-AB-2938-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELMOD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50092 single-organism process GO Biological Process Annotations 2015 1.0 null DU 145 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.972157 GTEX-QCQG-0226-SM-48U28 GTEx Tissue Sample Gene Expression Profiles 1.0 0.914999 blood vessel endothelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.071288 CCDC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14621 GSE150072,GSE169209_6_v_11_qser1_human RummaGEO Gene Perturbation Signatures 1.0 null 496100313_HIP_possible Alzheimer's disease_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.38879 gastrointestinal cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.061115 skeletal muscle HPA Tissue Gene Expression Profiles -1.0 -1.06394 anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.862357 Metabolic dysfunction-associated steatotic liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.056 CASC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92679 fallopiantube_8c HPA Tissue Sample Gene Expression Profiles 1.0 1.19988 Mucous acinar cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.448 Pyloric cecum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.228 one-carbon compound transport GO Biological Process Annotations 2015 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7095-01A-21R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYC_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null glycerol transport GO Biological Process Annotations 2015 1.0 null Disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.575 GATA6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.2884 GTEX-SUCS-0006-SM-4DM59 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0392 large intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057708 PMC11096100-41588_2024_1714_MOESM3_ESM.xlsx-ST18-Unnamed_1_ST18 Rummagene Transcription Factor Associations 2026 1.0 null pyramidal layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13103 NCI-H1993 COSMIC Cell Line Gene CNV Profiles 1.0 2.3178 GTEX-NL4W-0006-SM-2I3GH GTEx Tissue Sample Gene Expression Profiles 1.0 1.12466 HCC2302 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.79383 AMO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26356 FEZF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 65.2717 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6517-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OXRO-0326-SM-33HBM GTEx Tissue Sample Gene Expression Profiles 1.0 0.948676 143B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.38725 Enterocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.644 Polar tube COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.228 Nephrogenic diabetes insipidus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.387 estradiol_homo sapiens_gpl570_gds3283 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 1483_CENPJ_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.658088 HOS COSMIC Cell Line Gene CNV Profiles 1.0 2.3178 hippocampus (hippocampal formation)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.979376 CTCF_fibroblast of pulmonary artery_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MM.1S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02419 dentate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.10474 7566_RRP7A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.537087 VOPP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23298 MOLM16 CCLE Cell Line Gene Expression Profiles 1.0 1.87908 cardiovascular system disease GWASdb SNP-Disease Associations 1.0 0.097956 corneocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.723631 CHP-212 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.867458 CDK5_knockdown_99_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.64363 HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV7-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ARHGAP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79696 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-TSE9-0726-SM-3DB8C GTEx Tissue Sample Gene Expression Profiles 1.0 1.09601 SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 48.3053 GTEX-PW2O-0526-SM-2I3DX GTEx Tissue Sample Gene Expression Profiles 1.0 0.99536 OVCAR-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11591 Upper epidermis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.693 Basal part of cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.377 disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.045631 REST ENCODE Transcription Factor Targets 1.0 null Chloride channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.389 STAT5A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null normal GeneRIF Biological Term Annotations 1.0 null GTEX-X638-0005-SM-47JX6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.5195 COLO684 CCLE Cell Line Gene Expression Profiles -1.0 -2.90222 GTEX-PX3G-0006-SM-33HBQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.32004 Sleep disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.638 lateral intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.18794 muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057227 Acute Myeloid Leukemia_LAML_TCGA-AB-2916-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null frontal pole, right, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -3.29152 HEC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null 5737_NOL8_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.741717 MAX ENCODE Transcription Factor Targets 1.0 null LN-18 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18469 cellular process GO Biological Process Annotations 2015 1.0 null MDA-MB-435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18469 Sarcoma_SARC_TCGA-DX-A2J4-01A-32R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Allantoic fluid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.531 layer III of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.32182 HDAC1 ENCODE Transcription Factor Targets 1.0 null YMB-1-E Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.74075 TEAD4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47916 lateral hypothalamic area, mammillary region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.92275 PIK3R2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86333 GTEX-X4XY-0006-SM-46MV2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.943092 cell part LOCATE Curated Protein Localization Annotations 1.0 null Perturb_10123_KD_EGR1_SRP009615 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.94129 GSE163282_12_v_8_aspirin_human RummaGEO Drug Perturbation Signatures -1.0 null Neuroblastoma HuGE Navigator Gene-Phenotype Associations 1.0 null pb92 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.898 vacuole LOCATE Predicted Protein Localization Annotations 1.0 null H3K27me3_cardiac mesoderm_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC38 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.21818 YY1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HIPK2_knockdown_106_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.9793 b1647 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.604 COLO 792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05193 colonic cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063388 Brain Lower Grade Glioma_LGG_TCGA-DB-A64L-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Astrocyte projection COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.879 water homeostasis GO Biological Process Annotations 2015 1.0 null SKLMS1 DepMap CRISPR Gene Dependency 1.0 2.62493 Submandibular gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.33 Lens epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.86 vascular disease GWASdb SNP-Disease Associations 1.0 0.139719 paracentral lobule, posterior part, left, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1497 dorsal thalamus_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.971352 Brain Lower Grade Glioma_LGG_TCGA-HT-7858-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NAGLU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24471 trochlear nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2831 7469_RPL38_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.589833 hsa-miR-4795-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 primary motor cortex (area M1, area 4)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.92322 ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.3702 MRPL23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18341 KHM-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.33387 elucidate GeneRIF Biological Term Annotations 1.0 null MITF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.4479 protecting GeneRIF Biological Term Annotations 1.0 null response to acidic pH GO Biological Process Annotations 2023 1.0 null Alimentary canal TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE158632_3_v_5_oxyquinoline_human RummaGEO Drug Perturbation Signatures 1.0 null micropexophagy-specific membrane apparatus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.821 glycerol transmembrane transport GO Biological Process Annotations 2023 1.0 null Diabetes insipidus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.204 Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7Q0-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null influenced GeneRIF Biological Term Annotations 1.0 null HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NPRL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3863 lateral hypothalamic area, anterior region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.33449 small intestine TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.329 PANC 05.04 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.984185 Small intestine epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.664 GTEX-Q2AG-0005-SM-33HBX GTEx Tissue Sample Gene Expression Profiles 1.0 1.22709 aqp3 GeneRIF Biological Term Annotations 1.0 null NCIH1993 DepMap CRISPR Gene Dependency 1.0 2.58237 SNU119 CCLE Cell Line Gene Expression Profiles -1.0 -1.75465 KHM1B CCLE Cell Line Gene CNV Profiles 1.0 2.26247 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4114-01A-01R-1193-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE158182_4_v_0_pnpla3_human RummaGEO Gene Perturbation Signatures 1.0 null PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_CCRFCEM_ChIP-seq_TCF12 Rummagene Transcription Factor Associations 2026 1.0 null TRIM28_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-POMQ-0006-SM-33HBY GTEx Tissue Sample Gene Expression Profiles 1.0 1.03136 AU565 CCLE Cell Line Gene CNV Profiles 1.0 1.34549 JHH-7 COSMIC Cell Line Gene Mutation Profiles 1.0 null CDK4_knockdown_225_GSE8866 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.24564 7559_RRN3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.500728 GTEX-S95S-0005-SM-2XCEC GTEx Tissue Sample Gene Expression Profiles 1.0 1.34606 H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null STAT3_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-33-4583-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF1 ENCODE Transcription Factor Targets 1.0 null CABIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21128 PBX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30541 SH2D2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14153 BXPC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05083 Coronary Disease HuGE Navigator Gene-Phenotype Associations 1.0 null Zymogen granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.191 ELP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69778 KDM1A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DB DepMap CRISPR Gene Dependency 1.0 3.33363 protein homotetramerization GO Biological Process Annotations 2023 1.0 null Rheumatoid arthritis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 PDP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56251 choroid TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.297089 carbohydrate transport GO Biological Process Annotations 2015 1.0 null Rectum adenocarcinoma_READ_TCGA-EI-6883-01A-31R-1928-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null esophagus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.340019 GSE201309_1_v_8_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null 5731_NOC4L_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.941187 glycerol transmembrane transporter activity GO Molecular Function Annotations 2025 1.0 null NRARP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5292 MYCN-27167114-CHIP-SEQ-NEUROBLASTOMA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Brain Lower Grade Glioma_LGG_TCGA-RY-A83Z-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 2858_FAM136A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.546766 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 urinary tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.518465 abnormalities of the peripheral arteries GWASdb SNP-Phenotype Associations 1.0 0.218459 gut TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.092239 GSE167956_1_v_0_trim28_human RummaGEO Gene Perturbation Signatures 1.0 null CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2694 TCP1_02_194 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.60363 kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.160387 NCIH292 DepMap CRISPR Gene Dependency 1.0 3.35697 Catecholaminergic neuron TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.552 Parotid gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.187 PMC8656035-40001_2021_613_MOESM2_ESM.docx-46-ARNT_ARNT Rummagene Transcription Factor Associations 2026 1.0 null muscle GTEx Tissue Gene Expression Profiles -1.0 -1.11169 ZFP69B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34106 PMC10274973-media-3.xlsx-ST18-Supplementary_Table_18_476_Bonferroni_significant_results_P_2_67_x_10-6_of_gene_based_association_analyses_H-MAGMA_dlPFC_cortical_neurons_for_sensation_seeking_factor_ST18 Rummagene Transcription Factor Associations 2026 1.0 null Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.363 water transmembrane transporter activity GO Molecular Function Annotations 2023 1.0 null epidermal cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.227445 Musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.073 CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null atherosclerosis GWASdb SNP-Phenotype Associations 1.0 0.277658 GTEX-OXRL-0005-SM-3LK6A GTEx Tissue Sample Gene Expression Profiles 1.0 1.67268 GTEX-WOFM-0126-SM-3MJFE GTEx Tissue Sample Gene Expression Profiles 1.0 1.07303 GTEX-SNOS-0426-SM-32PMH GTEx Tissue Sample Gene Expression Profiles 1.0 1.5538 LB771HNC DepMap CRISPR Gene Dependency 1.0 3.9802 Breast cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.144 epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.401386 NOA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25159 5707_NMD3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.54831 hsa-miR-4446-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 posteroventral (inferior) parietal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.989478 GSE201309_5_v_7_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null Gastric fundus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.607 CTPS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22318 temporal pole, left, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.911132 SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T8-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null fatty liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.347879 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-NPJ7-0006-SM-3GACR GTEx Tissue Sample Gene Expression Profiles 1.0 1.2648 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.169 2580_EIF6_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.529541 Cortical collecting duct TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.793 intermediate portion of DFC (area 9/46) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.84732 C4orf48 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63872 TBL1XR1 ENCODE Transcription Factor Targets 1.0 null Non-albumin protein levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.2 H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null 859_BMS1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.06501 CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7433_RPL11_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.665911 FAM20C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87551 ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell volume homeostasis GO Biological Process Annotations 2015 1.0 null GTEX-OIZH-0526-SM-2HMKV GTEx Tissue Sample Gene Expression Profiles 1.0 1.21287 Adrenocortical carcinoma_ACC_TCGA-OR-A5L9-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posteroventral (inferior) parietal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.50667 CTCF_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null 4523_LAS1L_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.560059 motor nucleus of trigeminal nerve, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.973695 Lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.129 Lung squamous cell carcinoma_LUSC_TCGA-85-8052-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Unnamed_1_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-PWOO-0006-SM-2I3E3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.904572 G96 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.93579 MYCN-28898695-NB1643-HUMAN-NERVE-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.722398 spanning component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.492561 CatSper complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.652 NCIH1623 CCLE Cell Line Gene CNV Profiles 1.0 1.96835 salivary gland HPA Tissue Gene Expression Profiles -1.0 -1.06394 GTEX-OIZF-0006-SM-2I5GQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.26174 Lung adenocarcinoma_LUAD_TCGA-91-6835-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bipolar disorder GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.569897 KMS28BM CCLE Cell Line Gene CNV Profiles 1.0 1.72021 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.55 PMC12518476-10067_2025_7574_MOESM9_ESM.xlsx-Sheet2-RNAseq_DEGs_of_KD_AR Rummagene Transcription Factor Associations 2026 1.0 null PMC8040704-jcav12p2673s2.xlsx-Up-regulated_genes_in_EBF1-Unnamed_0_EBF1 Rummagene Transcription Factor Associations 2026 1.0 null TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null NCI-H2110 COSMIC Cell Line Gene CNV Profiles 1.0 2.3178 GTEX-P4PP-0926-SM-48TBZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.05342 GSE201309_1_v_6_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null 9818_WDR3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.525059 transmembrane transport GO Biological Process Annotations 2015 1.0 null HS888T CCLE Cell Line Gene Expression Profiles -1.0 -1.59012 WM-266-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.933617 arterial stenosis GWASdb SNP-Phenotype Associations 1.0 0.218459 GSE131649_6_v_9_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null Intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.386 7525_RPS3_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.732391 posteroventral (inferior) parietal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.82891 GABPA ENCODE Transcription Factor Targets 1.0 null GSE178714_1_v_4_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null P68-20966046-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SG in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0799 SPI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.31521 dentate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.90423 female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055845 CDX2-21074721-CACO-2-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CEBPA-26348894-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Brush border membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.883 subgranular zone of caudal dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.989452 5673_NIP7_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.652645 ABRAXAS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.12141 Chronic Otitis Media DisGeNET Gene-Disease Associations 1.0 null Pancreatic acinar cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.012 would GeneRIF Biological Term Annotations 1.0 null Oxyntic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.271 GSE193258,GSE193259_5_v_15_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null PAX8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.5282 Primary immunodeficiency disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 COLO680N CCLE Cell Line Gene Expression Profiles -1.0 -1.83812 membrane GO Cellular Component Annotations 2015 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.49955 Rdw - Red Blood Cell Distribution Width Result DisGeNET Gene-Phenotype Associations 1.0 null TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE131649_4_v_10_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null CHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43074 integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 NCIH1568 CCLE Cell Line Gene CNV Profiles 1.0 1.48401 colorectal cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.070483 MRPL10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32265 colorectal adenocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.077126 Brain Lower Grade Glioma_LGG_TCGA-DU-7292-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary auditory cortex (core)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.59328 small intestine epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.685143 GTEX-SIU7-0006-SM-2XCE6 GTEx Tissue Sample Gene Expression Profiles 1.0 2.16199 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5879-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ileocecum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.114445 TENT4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07044 IGSF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42617 GTEX-X4EP-0526-SM-3P5YW GTEx Tissue Sample Gene Expression Profiles 1.0 1.28402 GSE68925_1_v_0_fasudil_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-A5NK-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 3T3-L1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.228 496100384_HIP_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.97159 membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.433801 GSE211128_9_v_0_angptl4_human RummaGEO Gene Perturbation Signatures 1.0 null Duodenum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.564 GTEX-POYW-1226-SM-2XCEP GTEx Tissue Sample Gene Expression Profiles 1.0 0.850721 Celiac disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.041 response to stimulus GO Biological Process Annotations 2015 1.0 null glandular epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.223419 HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null cellular response to pH GO Biological Process Annotations 2023 1.0 null internal male genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057647 GATA6-21074721-CACO-2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Integumentary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.023 EP300_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null basomedial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.14532 GTEX-PW2O-0006-SM-2I3DV GTEx Tissue Sample Gene Expression Profiles 1.0 1.63308 Lung squamous cell carcinoma_LUSC_TCGA-56-8309-01A-11R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.29933 amide transport GO Biological Process Annotations 2015 1.0 null ATF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary immunodeficiency disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.428 HOXC9 ChEA Transcription Factor Targets 1.0 null vascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060146 Colorectal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.187 superior occipital gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.75364 GTEX-TMZS-0006-SM-3DB8G GTEx Tissue Sample Gene Expression Profiles 1.0 1.6646 Duodenum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.669 Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5Q6-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H460 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12148 Lysosomal storage disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.077 FBXL19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83599 fallopiantube_8e HPA Tissue Sample Gene Expression Profiles 1.0 1.09499 tail of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.04764 USF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.3594 3446_GNL3L_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.01979 H3K27me3_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8512-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ETFDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18966 GATA2 ChEA Transcription Factor Targets 1.0 null extrapulmonary tuberculosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.757378 Neuromast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.555 KATO III Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.865835 NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.15893 Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.681 GTEX-Q734-0006-SM-2I3FJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.59375 water transport GO Biological Process Annotations 2025 1.0 null CTCF_LNCaP clone FGC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE131649_2_v_9_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null NCIH2141 CCLE Cell Line Gene Expression Profiles -1.0 -2.29865 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null establishment of localization GO Biological Process Annotations 2015 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7732-01A-11R-2139-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Villus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.602 Whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.564 bed nucleus of stria terminalis, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.93293 cerebellar cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.46435 GTEX-WRHK-0005-SM-3MJF5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.74529 cellular_component LOCATE Curated Protein Localization Annotations 1.0 null reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.391931 G112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.830089 GATA1 ENCODE Transcription Factor Targets 1.0 null HS 746T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.54597 plant-type vacuole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.075 ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.825298 hsa-miR-4266 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 TMEM237 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17734 L3MBTL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2108 Sweat gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.455 Otitis Media With Effusion DisGeNET Gene-Disease Associations 1.0 null KMM1 DepMap CRISPR Gene Dependency 1.0 3.51845 Vaginal mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.66 cell adhesion molecules GAD Gene-Disease Associations 1.0 null 7312_RIOK2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.652392 ACAA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21129 dorsolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.893112 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JK-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-6985-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 7502_RPS14_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.812242 tetramer GeneRIF Biological Term Annotations 1.0 null protein homooligomerization GO Biological Process Annotations 2025 1.0 null 7465_RPL36A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.516111 INAVA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80292 basolateral plasma membrane GO Cellular Component Annotations 2025 1.0 null glycerol channel activity GO Molecular Function Annotations 2025 1.0 null facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.825415 tear gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.190082 SPI1-20517297-HL60-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-R55C-0526-SM-3GIKA GTEx Tissue Sample Gene Expression Profiles 1.0 1.14201 dorsal motor nucleus of the vagus (vagal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.28569 UCSD-242L Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.0261 GATA2_SH-SY5Y_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-CA-04-2009(H1N1)_0Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.43899 pretectal nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.953641 SW 527 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.826074 7458_RPL30_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.798406 ATF1 ENCODE Transcription Factor Targets 1.0 null GTEX-T5JW-0005-SM-3GADE GTEx Tissue Sample Gene Expression Profiles 1.0 1.37042 Heart conduction disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.711 H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Intercellular canaliculus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.167 2233_DIS3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.510462 layer III of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.36133 BBIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83871 Basolateral plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 GTEX-WYVS-0006-SM-3NMA7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.32021 PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_up_VENN-697_elements_included_exclusively_in_HIF1_genes_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null ELK1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null motifs GeneRIF Biological Term Annotations 1.0 null GTEX-POYW-0006-SM-2XCF4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.96301 Lung adenocarcinoma_LUAD_TCGA-38-4627-11A-01R-1758-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null physiological GeneRIF Biological Term Annotations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5361-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC2218 CCLE Cell Line Gene CNV Profiles 1.0 1.81492 CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OOBJ-0526-SM-48TDK GTEx Tissue Sample Gene Expression Profiles 1.0 0.883486 GSE138633_2_v_0_bag3_human RummaGEO Gene Perturbation Signatures 1.0 null Viscus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.564 PACSIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15032 posterior hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.46977 HOS CCLE Cell Line Gene CNV Profiles 1.0 1.86359 Mercury CTD Gene-Chemical Interactions 1.0 null GTEX-OOBK-0526-SM-2HMJJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.0894 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null gastrointestinal tuberculosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.17507 hsa-miR-3202 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 further GeneRIF Biological Term Annotations 1.0 null SIRT6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.64337 GTEX-XPVG-0626-SM-4B65B GTEx Tissue Sample Gene Expression Profiles 1.0 0.875528 Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7963-01B-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Salivary gland cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.599 inflammatory bowel disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.415773 NCIH28 DepMap CRISPR Gene Dependency 1.0 3.28682 Gastrointestinal tract TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.564 lateral hypothalamic area, mammillary region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.00824 6536_POLR1C_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.596089 GTEX-PLZ6-0006-SM-33HBZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.89432 CAVIN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13457 SW1271 CCLE Cell Line Gene CNV Profiles -1.0 -1.73594 HCC2185 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.836927 GTEX-WH7G-0005-SM-3NMBX GTEx Tissue Sample Gene Expression Profiles 1.0 1.35384 ERICH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13721 cholera DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.296211 GTEX-WHSB-0005-SM-3LK7C GTEx Tissue Sample Gene Expression Profiles 1.0 1.35168 PAX9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.4035 small intestine HPA Tissue Gene Expression Profiles 1.0 1.39222 MAFG::NFE2L1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.3436 abdominal tuberculosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.13712 outer CP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.929533 Genetic Predisposition to Disease HuGE Navigator Gene-Phenotype Associations 1.0 null PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Up_regulated_DEGs_of_KD_AR Rummagene Transcription Factor Associations 2026 1.0 null KMS26 DepMap CRISPR Gene Dependency 1.0 2.20813 7505_RPS16_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.71762 GSE207301,GSE207303_1_v_2_tp53bp2_human RummaGEO Gene Perturbation Signatures 1.0 null KMS20 DepMap CRISPR Gene Dependency 1.0 2.74055 carbohydrate transporter activity GO Molecular Function Annotations 2015 1.0 null 496100478_HIP_dementia_TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.93221 H3K27me3_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null alimentary canal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.816486 7576_RSL1D1_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.885445 intestine GeneRIF Biological Term Annotations 1.0 null H3K27me3_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null polarity GeneRIF Biological Term Annotations 1.0 null GTEX-QDT8-0006-SM-32PL3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.49726 SGPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22587 lens TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.173171 cardiovascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058652 ZMIZ1 ENCODE Transcription Factor Targets 1.0 null GTEX-W5WG-0006-SM-3GIJT GTEx Tissue Sample Gene Expression Profiles 1.0 2.65318 MMP16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82138 Red cell distribution width GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.2699 Brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.228 villus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.540981 plasma membrane part GO Cellular Component Annotations 2015 1.0 null arteriosclerosis GWASdb SNP-Phenotype Associations 1.0 0.243512 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A464-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KLM1 CCLE Cell Line Gene Expression Profiles -1.0 -1.81852 SKLU1 CCLE Cell Line Gene CNV Profiles -1.0 -1.47496 NU-DUL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.946658 TNK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17189 H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U412-0006-SM-3DB8J GTEx Tissue Sample Gene Expression Profiles 1.0 0.911631 KURAMOCHI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.970904 JR DepMap CRISPR Gene Dependency 1.0 2.55985 SKNBE2 CCLE Cell Line Gene Expression Profiles 1.0 1.41375 H3K27me3_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null diarrhea DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.501144 Lung squamous cell carcinoma_LUSC_TCGA-66-2759-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TP63 ChEA Transcription Factor Targets 1.0 null GATA1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8755441-mmc3.xlsx-IRF7-Up-ezh2_IRF7 Rummagene Transcription Factor Associations 2026 1.0 null GSE131649_6_v_0_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null CEBPD ENCODE Transcription Factor Targets 1.0 null 496100656_HIP_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.25492 TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null H3K27me3_cardiac mesoderm_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAOV3 DepMap CRISPR Gene Dependency 1.0 3.52182 Cranial nerve disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.094 ccnd1_18413728_imr_neuroblastoma_lof_human_gpl570_gse8866 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.089416 GTEX-X88G-0006-SM-47JX5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07943 ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null carbohydrate transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A3VY-01A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IDS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01472 Lung squamous cell carcinoma_LUSC_TCGA-O2-A52V-01A-31R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-5872-02A-21R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Stratum corneum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.394 TM-3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.944 Prostate adenocarcinoma_PRAD_TCGA-EJ-5521-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormality of the vasculature GWASdb SNP-Phenotype Associations 1.0 0.609228 GATA6-25053715-YYC3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null NCCSTCK140 CCLE Cell Line Gene CNV Profiles -1.0 -2.19856 SPRY4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77503 Taste bud TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.614 CDK8_knockdown_88_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.11166 Inner medullary collecting duct TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.999 KINGS-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Sertoli cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.052 SELENOF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24268 PMC11976269-41375_2025_2519_MOESM3_ESM.xlsx-ChIP_GATA2_Cluster_A-GeneName_GATA2 Rummagene Transcription Factor Associations 2026 1.0 null orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.84023 eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7426_RPF1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.534 DYNLL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49745 MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE205163,GSE205164_2_v_4_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null GSE155031_5_v_3_dextran_human RummaGEO Drug Perturbation Signatures -1.0 null CEBPB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU398 DepMap CRISPR Gene Dependency 1.0 2.64066 GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles 1.0 2.49405 NURR1 MotifMap Predicted Transcription Factor Targets 1.0 null GSE184892_6_v_1_trehalose_human RummaGEO Drug Perturbation Signatures -1.0 null Tear gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.021 GATA2_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE150055_0_v_1_melphalan_human RummaGEO Drug Perturbation Signatures 1.0 null capillary endothelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.57082 ae2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.839 Mean corpuscular volume GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.52218 OVTOKO DepMap CRISPR Gene Dependency 1.0 4.26364 LN443 CCLE Cell Line Gene CNV Profiles -1.0 -1.40389 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HL-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null temporal pole, right, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08432 plasma membrane region COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.13491 Apical recycling endosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.622 GSE158632_2_v_4_oxyquinoline_human RummaGEO Drug Perturbation Signatures 1.0 null Basal plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 PHF8 ENCODE Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7104-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Connecting tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.098 7507_RPS18_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.580201 isoform GeneRIF Biological Term Annotations 1.0 null CDT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63929 HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.865835 TF1 CCLE Cell Line Gene Expression Profiles 1.0 1.48949 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.614974 Hepatocellular carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.022 OVMIU COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE178714_3_v_0_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A6C4-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FAM171A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69833 nephrogenic diabetes insipidus DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.802385 SJCRH30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.972036 GTEX-PLZ5-1526-SM-3P5ZX GTEx Tissue Sample Gene Expression Profiles 1.0 1.03749 Cholera DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.029 plant-type vacuole membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.139 496100316_TCx_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.03681 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5C1-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.17284 GSE205163,GSE205164_5_v_4_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null CMTR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55441 SNAI3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.1185 inner CP in (rostral) midinferior temporal cortex (area 36) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.876964 SIN3A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AU565 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.713737 inner SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.882645 GTEX-WFON-0126-SM-4LVM9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.18214 GSE201309_5_v_3_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null Outer acrosomal membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.706 GSE220613_0_v_1_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null Autoimmune disease of musculoskeletal system DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 LRRC8A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38214 molecular_function GO Molecular Function Annotations 2015 1.0 null HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.6773 fallopian tube HPA Tissue Gene Expression Profiles 1.0 0.965983 Rectum adenocarcinoma_READ_TCGA-AG-3732-01A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5152-01A-02R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF135 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 55.1762 primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.967509 GTEX-QMRM-0826-SM-3NB33 GTEx Tissue Sample Gene Expression Profiles 1.0 0.852179 USF MotifMap Predicted Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-6745-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null plasma membrane GO Cellular Component Annotations 2015 1.0 null UT7 CCLE Cell Line Gene Expression Profiles 1.0 1.62717 GSE195559_0_v_1_notch1_human RummaGEO Gene Perturbation Signatures 1.0 null HADHB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2757 MZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08907 head muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.282837 PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null HPRT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07963 GTEX-XXEK-0005-SM-4BRWJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.00256 plasma membrane LOCATE Curated Protein Localization Annotations 1.0 null Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE131649_6_v_5_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null TOLEDO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.40042 adipocytes GeneRIF Biological Term Annotations 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-63-A5MV-01A-21R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 7513_RPS24_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.943049 GTEX-XBEC-0006-SM-4AT5T GTEx Tissue Sample Gene Expression Profiles 1.0 1.11174 integral component of plasma membrane GO Cellular Component Annotations 2015 1.0 null member GeneRIF Biological Term Annotations 1.0 null HCC1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.983081 4945_MED22_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.55639 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7065-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SHSY5Y DepMap CRISPR Gene Dependency 1.0 2.15898 CTCF_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2GZ-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE114883_1_v_2_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null STAT5A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MS-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Autoimmune disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 GTEX-OIZG-0005-SM-2HMJC GTEx Tissue Sample Gene Expression Profiles 1.0 1.25586 GTF2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null capillary TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.284253 obesity GeneRIF Biological Term Annotations 1.0 null Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.313 Psoriasis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.004 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.620621 H3K27me3_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null one GeneRIF Biological Term Annotations 1.0 null CTCF_BE2C_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-5853-01A-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Intestinal tuberculosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.101 TAF15_02_163 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59232 POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XQ3S-0006-SM-4BOQ4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.974634 PECAPJ49 CCLE Cell Line Gene CNV Profiles -1.0 -2.11303 16397240-SuppTable3 GeneSigDB Published Gene Signatures 1.0 null Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.241 Stratum granulosum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.864 7569_RRS1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.758596 874_BOP1_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.688935 caudal subdivision of medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.871499 Ileum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.572 primary auditory cortex (core)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.03542 715_AURKB_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.678525 FAM217B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48737 7438_RPL14_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.566871 CYP2R1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29977 tuberculosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.231448 skin TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.393819 Symbiosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.738 NB1 CCLE Cell Line Gene CNV Profiles 1.0 1.40778 NCIH929 CCLE Cell Line Gene CNV Profiles 1.0 1.56575 UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cardiovascular GAD High Level Gene-Disease Associations 1.0 0.298214 PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-CA-ID_PTF1A Rummagene Transcription Factor Associations 2026 1.0 null carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051762 EIF4EBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84473 MHHNB11 DepMap CRISPR Gene Dependency 1.0 2.57226 PAX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6332 small GeneRIF Biological Term Annotations 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-6148-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-DX-A3UB-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NFK9-0006-SM-3GACS GTEx Tissue Sample Gene Expression Profiles 1.0 0.857074 channel activity GO Molecular Function Annotations 2023 1.0 null GSE178714_5_v_2_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NQ-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UACC893 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.922258 gastrointestinal tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.833223 transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null GSE131649_6_v_3_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-SIU8-0006-SM-2XCE5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.931935 orbital frontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.856207 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.858 AK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48473 Lung squamous cell carcinoma_LUSC_TCGA-58-8393-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X3Y1-0006-SM-3P5ZG GTEx Tissue Sample Gene Expression Profiles 1.0 1.17128 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A8AZ-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lytic vacuole LOCATE Predicted Protein Localization Annotations 1.0 null FOSL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.5226 fluid transport GO Biological Process Annotations 2015 1.0 null HCC1599 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.96657 cell part LOCATE Predicted Protein Localization Annotations 1.0 null H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DMS153 CCLE Cell Line Gene Expression Profiles -1.0 -1.4802 thus GeneRIF Biological Term Annotations 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I7-01A-21R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null water channel activity GO Molecular Function Annotations 2023 1.0 null supramarginal gyrus, left, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.841626 Intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.564 EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.831401 4713_LTV1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.550696 Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DK-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XUW1-0005-SM-4BOQ7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09665 Brain Lower Grade Glioma_LGG_TCGA-VM-A8CA-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LOVO DepMap CRISPR Gene Dependency 1.0 2.41991 3447_GNL3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.535976 BTBD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08804 interstitial nucleus of Cajal, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.00513 GTEX-OXRN-0526-SM-2I5EN GTEx Tissue Sample Gene Expression Profiles 1.0 1.01435 coronary artery disease GWASdb SNP-Phenotype Associations 1.0 0.516758 Cell Adhesion Molecules dbGAP Gene-Trait Associations 1.0 0.08503 rectal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068448 POU2F1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null GATA3-22897851-JUKARTE6-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null NUGC-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.826074 SW 1116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.32269 solute GeneRIF Biological Term Annotations 1.0 null RAB4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60698 cerebellar cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07603 single-organism localization GO Biological Process Annotations 2015 1.0 null GTEX-XGQ4-0005-SM-4AT5U GTEx Tissue Sample Gene Expression Profiles 1.0 1.13323 Columnar cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.059 LYAR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0653 neurological GAD High Level Gene-Disease Associations 1.0 0.293278 JIMT-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25514 2251_DMAP1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.522261 Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7841-01A-11R-A32Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.064379 TRAPPC2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3076 substrate-specific transporter activity GO Molecular Function Annotations 2015 1.0 null PMC10882188-ADB-29-e13365-s002.xlsx-ST18-Unnamed_8_ST18 Rummagene Transcription Factor Associations 2026 1.0 null HDMYZ DepMap CRISPR Gene Dependency 1.0 2.0022 GTEX-UPIC-0826-SM-3GADQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.827966 496100281_HIP_probable Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.0841 ZNF384 ENCODE Transcription Factor Targets 1.0 null 8660_TAF1D_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.740155 eGFP-GATA2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A8IH-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OPM2 CCLE Cell Line Gene CNV Profiles 1.0 1.67854 GTEX-UPJH-0006-SM-3GACW GTEx Tissue Sample Gene Expression Profiles 1.0 0.976604 Lung squamous cell carcinoma_LUSC_TCGA-85-8582-01A-21R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Secretory diarrhea DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.03 TMEM104 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94861 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Lung adenocarcinoma_LUAD_TCGA-44-6148-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 19855078-TableS2d GeneSigDB Published Gene Signatures 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A0VN-01A-21R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 5740_NOM1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.50091 Inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.452 PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_12_in_RNA-seq_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null Brush border COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.292 primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.10608 Skin disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.351 20300634-T2 GeneSigDB Published Gene Signatures 1.0 null adenocarcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052665 Medullary collecting duct TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.106 Adrenocortical carcinoma_ACC_TCGA-OR-A5JA-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hippocampus (hippocampal formation)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.75458 gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.244696 GTEX-S7SE-0005-SM-2XCEA GTEx Tissue Sample Gene Expression Profiles 1.0 1.05899 KMS11 DepMap CRISPR Gene Dependency 1.0 3.35515 ZNF708 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.3828 NCIH2110 CCLE Cell Line Gene CNV Profiles 1.0 1.63739 olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.99693 intrinsic component of plasma membrane GO Cellular Component Annotations 2015 1.0 null KLF4-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null USF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TM-4 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.062 GSE128634,GSE128636_4_v_3_foxo1_human RummaGEO Gene Perturbation Signatures -1.0 null spanning component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.492561 Large intestine cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.187 bacterial infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.331025 response to chemical GO Biological Process Annotations 2015 1.0 null 4780_MAK16_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.657933 IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.6303 EP300 ENCODE Transcription Factor Targets 1.0 null RARG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.421 Liver hepatocellular carcinoma_LIHC_TCGA-GJ-A6C0-01A-12R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A4BB-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MPDU1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16912 mediodorsal nucleus of thalamus_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.8152 PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_Jurkat_ChIP-seq_TCF12 Rummagene Transcription Factor Associations 2026 1.0 null IZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.22811 BXPC3 CCLE Cell Line Gene Expression Profiles -1.0 -1.62973 H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null rostral subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.63534 all GWASdb SNP-Phenotype Associations 1.0 0.030378 Immune system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.418 SLC35B3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34995 ASB8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63199 GTEX-S4Z8-0226-SM-4AD5K GTEx Tissue Sample Gene Expression Profiles 1.0 0.954326 Developmental disorder of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 7471_RPL39_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.593816 layer IIIa of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.44401 estradiol_homo sapiens_gpl14550_gse35034 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Psoriasis vulgaris_Skin tissue_GSE14905 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.55848 hsa-miR-4328 TargetScan Predicted Conserved microRNA Targets 1.0 0.085563 sclera TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.378372 signal GeneRIF Biological Term Annotations 1.0 null BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Red Cell Distribution Width Determination DisGeNET Gene-Phenotype Associations 1.0 null CAKI1 DepMap CRISPR Gene Dependency 1.0 2.5683 Urinary bladder TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.19 primary bacterial infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.344207 TMEM245 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85766 NCI-H1623 COSMIC Cell Line Gene Mutation Profiles 1.0 null NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TFAP2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.477 GSE193258,GSE193259_9_v_15_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K27me3_CD14-positive monocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.8278 ONECUT3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 59.3531 GTEX-QEL4-0826-SM-3GAF2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01887 ZSCAN21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.1753 GRB10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6747 GTEX-PVOW-0006-SM-3NMB8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.973863 GATA2-19941826-K562-HUMAN ChEA Transcription Factor Targets 2022 1.0 null masseter TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.482038 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Intestine TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BCPAP CCLE Cell Line Gene CNV Profiles -1.0 -1.90938 GTEX-T8EM-0006-SM-3DB71 GTEx Tissue Sample Gene Expression Profiles 1.0 1.11254 E2F1-20622854-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null primary auditory cortex (core)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.23495 MXI1 ENCODE Transcription Factor Targets 1.0 null 9766_VPS72_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.57828 NCIH1437 CCLE Cell Line Gene CNV Profiles 1.0 2.83312 Renal proximal tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.572 primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.898697 Acquired metabolic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.629 2127_DDX51_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.773332 SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14021 H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAL120 CCLE Cell Line Gene CNV Profiles -1.0 -1.4416 aqp10 GeneRIF Biological Term Annotations 1.0 null GTEX-R55E-0726-SM-48FCZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.83797 496100586_HIP_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.34297 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null targeting GeneRIF Biological Term Annotations 1.0 null rectal cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068919 MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STEAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79738 collecting duct TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.408592 renal artery disease GWASdb SNP-Disease Associations 1.0 0.708319 NCI-H1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.82078 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HG-A2PA-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CCK81 DepMap CRISPR Gene Dependency 1.0 2.7251 Prostate adenocarcinoma_PRAD_TCGA-ZG-A8QW-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null vertebrate muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058038 PMC13082837-NIHMS2159075-supplement-3.xlsx-DataTable5_Methylation_LMS-UCSC_RefGene_Name_TP63 Rummagene Transcription Factor Associations 2026 1.0 null KLF3_01_221 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 0.87517 RAP1GAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37367 SKLMS1 CCLE Cell Line Gene CNV Profiles -1.0 -2.08627 Colitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.057 CTCF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4Q7-0006-SM-3K2AT GTEx Tissue Sample Gene Expression Profiles 1.0 1.75491 Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A4TM-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JHUEM1 DepMap CRISPR Gene Dependency 1.0 3.72543 Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A562-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PFAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94744 GTEX-WFJO-0005-SM-3GIKY GTEx Tissue Sample Gene Expression Profiles 1.0 2.03332 Central element COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.629 6024_PABPC1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.544197 Aquaporin-like InterPro Predicted Protein Domain Annotations 1.0 null protein homooligomerization GO Biological Process Annotations 2023 1.0 null EP300_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100416_FWM_dementia_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.66156 organic substance transport GO Biological Process Annotations 2023 1.0 null Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.711 alzheimer's disease GAD Gene-Disease Associations 1.0 null ZNF140 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.5098 GTEX-O5YW-0006-SM-3LK6E GTEx Tissue Sample Gene Expression Profiles 1.0 1.43064 PHF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83291 striatum_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.984199 VZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20111 GSE205163,GSE205164_5_v_6_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WEY5-0006-SM-3GIKG GTEx Tissue Sample Gene Expression Profiles 1.0 1.5062 Disease of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 cellular homeostasis GO Biological Process Annotations 2015 1.0 null Prostate adenocarcinoma_PRAD_TCGA-ZG-A8QZ-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE216273,GSE216292_0_v_7_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null localized GeneRIF Biological Term Annotations 1.0 null NCI-H1395 COSMIC Cell Line Gene CNV Profiles 1.0 2.3178 H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of the systemic arterial tree GWASdb SNP-Phenotype Associations 1.0 0.119446 CORL279 CCLE Cell Line Gene Expression Profiles -1.0 -1.72494 PMC4580625-pone.0138726.s006.xlsx-Immune_molecular_modules-KLF1_mod_KLF1 Rummagene Transcription Factor Associations 2026 1.0 null TAF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null inner CP in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01673 gut epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.477756 PTOV1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82067 YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell part GO Cellular Component Annotations 2015 1.0 null 9839_WDR74_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.792152 GSE131649_2_v_7_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE102870_7_v_0_nr1h4_human RummaGEO Gene Perturbation Signatures -1.0 null GSE131649_2_v_1_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null excretory gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.387027 hsa-miR-1470 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 Juvenile rheumatoid arthritis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 EKVX CCLE Cell Line Gene CNV Profiles 1.0 1.42948 GTEX-P4QS-0326-SM-2I3EU GTEx Tissue Sample Gene Expression Profiles 1.0 0.963743 cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.66046 GSE176144_0_v_1_zfc3h1_human RummaGEO Gene Perturbation Signatures 1.0 null SLC25A44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10241 H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null PANC 04.03 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04809 amygdalostriatal transition area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.854946 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNUC5 DepMap CRISPR Gene Dependency 1.0 2.55402 EIF2AK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71722 embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052864 7561_RRP12_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.615909 Sperm midpiece COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.382 TSPOAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52812 Small intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.564 TEN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49707 Brain - Anterior cingulate cortex (BA24) GTEx Tissue Gene Expression Profiles 2023 1.0 6.46143 GTEX-RM2N-0006-SM-2TF5H GTEx Tissue Sample Gene Expression Profiles 1.0 1.70813 GSE162892_4_v_0_sox9_human RummaGEO Gene Perturbation Signatures -1.0 null intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.847065 3445_GNL2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.613514 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LS-01A-22R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.326829 EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-RY-A843-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CJM CCLE Cell Line Gene CNV Profiles -1.0 -1.60326 NCI-H1781 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.33387 MYC ENCODE Transcription Factor Targets 1.0 null GTEX-QMRM-0005-SM-3NB2A GTEx Tissue Sample Gene Expression Profiles 1.0 1.88902 smallintestine_4d HPA Tissue Sample Gene Expression Profiles 1.0 1.23725 crohn's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.557509 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4342-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TE10 CCLE Cell Line Gene CNV Profiles -1.0 -1.39415 Zymogen granule membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.167 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.030421 MZ in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.960123 G140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05083 cellular response to acidic pH GO Biological Process Annotations 2023 1.0 null HMGN3 ENCODE Transcription Factor Targets 1.0 null GSE131649_2_v_11_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-Row_names_CENPX Rummagene Transcription Factor Associations 2026 1.0 null mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.587629 fallopiantube_8b HPA Tissue Sample Gene Expression Profiles 1.0 0.859434 Lung adenocarcinoma_LUAD_TCGA-44-5645-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lysosome LOCATE Predicted Protein Localization Annotations 1.0 null skeletal system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055037 143B CCLE Cell Line Gene CNV Profiles 1.0 1.53671 stability GeneRIF Biological Term Annotations 1.0 null nitrogen compound transport GO Biological Process Annotations 2015 1.0 null MEG01 CCLE Cell Line Gene Expression Profiles 1.0 1.42718 alcohol transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null ITGB3BP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09375 Astrocyte end-foot COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.708 Adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.074 Lung adenocarcinoma_LUAD_TCGA-49-4512-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12518476-10067_2025_7574_MOESM9_ESM.xlsx-Sheet2-intersection_DEGs_of_KD_AR Rummagene Transcription Factor Associations 2026 1.0 null colonic cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064453 JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null duodenum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.598871 GTEX-SUCS-1326-SM-4DM5T GTEx Tissue Sample Gene Expression Profiles 1.0 0.950639 GSE216273,GSE216292_14_v_1_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null Plasma membrane region COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 Subapical complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.676 GATA3_SH-SY5Y_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H358 COSMIC Cell Line Gene Mutation Profiles 1.0 null Syntrophin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.109 GTEX-T6MO-0006-SM-32QOU GTEx Tissue Sample Gene Expression Profiles 1.0 1.91495 EZH2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SCC4 CCLE Cell Line Gene CNV Profiles -1.0 -1.75074 substantia innominata, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.57257 GTEX-R55E-0006-SM-2TC5G GTEx Tissue Sample Gene Expression Profiles 1.0 0.874761 GSE205163,GSE205164_9_v_4_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null inner SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10903 PMC11282827-40659_2024_524_MOESM5_ESM.xlsx-TAL1-sequence_name_TAL1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QLQW-0005-SM-2S1RA GTEx Tissue Sample Gene Expression Profiles 1.0 0.886079 Acute Myeloid Leukemia_LAML_TCGA-AB-2941-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE205687_1_v_0_mta1_human RummaGEO Gene Perturbation Signatures -1.0 null CHAF1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03086 STARD3NL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96181 GSE162892_4_v_2_sox9_human RummaGEO Gene Perturbation Signatures -1.0 null Neuromyelitis optica DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.509 RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.74996 HCC1419 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.10241 MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1 ENCODE Transcription Factor Targets 1.0 null without GeneRIF Biological Term Annotations 1.0 null urinary bladder TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.454126 GATA3-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null MIS18A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22488 ventromedial hypothalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19863 organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051564 GTEX-WXYG-0005-SM-3NB3M GTEx Tissue Sample Gene Expression Profiles 1.0 1.25181 Respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.234 GTEX-XOT4-1426-SM-4B65T GTEx Tissue Sample Gene Expression Profiles 1.0 0.82511 CELF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08673 VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.12106 D283MED CCLE Cell Line Gene Expression Profiles 1.0 2.12715 H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Alimentary canal TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.564 G111 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.93719 TMEM183A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51833 Secretory granule membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.44 TNRC6C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42013 epidermis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.350743 ciliary epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.535438 GTEX-XMK1-0005-SM-4B665 GTEx Tissue Sample Gene Expression Profiles 1.0 1.43753 Major intrinsic protein, conserved site InterPro Predicted Protein Domain Annotations 1.0 null passive transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null protein homotetramerization GO Biological Process Annotations 2025 1.0 null SNU-601 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0863 EBNA2-21746931-IB4-LCL-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ELF1-20517297-JURKAT-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-XYKS-0005-SM-4BRUD GTEx Tissue Sample Gene Expression Profiles 1.0 1.35025 2789_EXOSC2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.636766 Basolateral plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.444 5138_MOB4_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.51949 2321_DNTTIP2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.576472 Brain Ischemia HuGE Navigator Gene-Phenotype Associations 1.0 null Porosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.676 EZH2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Spleen-platelet Tabula Sapiens Gene-Cell Associations 1.0 -7.02288E-4 artery disease GWASdb SNP-Disease Associations 1.0 0.185419 channel activity GO Molecular Function Annotations 2025 1.0 null cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.40714 GTEX-RTLS-0006-SM-2TF58 GTEx Tissue Sample Gene Expression Profiles 1.0 0.88328 well GeneRIF Biological Term Annotations 1.0 null mpkCCD cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.677 GTEX-QVJO-0006-SM-2S1RC GTEx Tissue Sample Gene Expression Profiles 1.0 1.10143 TUHR4TKB DepMap CRISPR Gene Dependency 1.0 2.0138 Ciliary epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.953 Crohn's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.11 5748_NOP2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.52568 RELA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.2778 integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.803544 HNFA-21074721-CACO-2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-7696-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5325-01A-01R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Salivary gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.711 4472_KRR1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.552766 plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 ACO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00725 blood GTEx Tissue Gene Expression Profiles 1.0 1.65189 GTEX-RVPU-0005-SM-2TF6L GTEx Tissue Sample Gene Expression Profiles 1.0 0.967004 ADCY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70764 GTEX-OHPN-0005-SM-2YUML GTEx Tissue Sample Gene Expression Profiles 1.0 0.827054 tongue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.357058 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3B7-01A-31R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Right colon TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.885 ZNF534 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77624 ELF1 ChEA Transcription Factor Targets 1.0 null SKNFI CCLE Cell Line Gene Expression Profiles 1.0 1.97139 5734_NOL12_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.540746 CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1 ChEA Transcription Factor Targets 1.0 null membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 7538_RPS8_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.12483 primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.16648 water transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null intestinal GeneRIF Biological Term Annotations 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8046-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TR-146 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.518 basolateral plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.342285 TE4 DepMap CRISPR Gene Dependency 1.0 2.23022 NR2F2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null localization GO Biological Process Annotations 2015 1.0 null Sweat gland disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.168 PA-TU-8902 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0863 SP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63992 ACTN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06893 7713_SDAD1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.610081 convey GeneRIF Biological Term Annotations 1.0 null GTEX-SNOS-0006-SM-32PLH GTEx Tissue Sample Gene Expression Profiles 1.0 1.46971 SCAMP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84098 stomach TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.096865 6534_POLR1B_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.15744 GTEX-QEG5-0006-SM-2I5FZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.970346 colonic adenocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.084403 Perturb_9822_KD_RUNX1_SRP103740 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 8.99855 Endocrine system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.19 outer SZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.883749 7493_RPP40_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.506102 GTEX-WFG7-0005-SM-3GIKM GTEx Tissue Sample Gene Expression Profiles 1.0 1.14803 Lens fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.414 precommissural nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.46021 Diabetes Mellitus, Type 2 HuGE Navigator Gene-Phenotype Associations 1.0 null hsa-miR-663 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 RH30 CCLE Cell Line Gene Expression Profiles -1.0 -1.49496 GTEX-TKQ1-0006-SM-33HBI GTEx Tissue Sample Gene Expression Profiles 1.0 0.84578 SOX10 MotifMap Predicted Transcription Factor Targets 1.0 null ELF1-20517297-JURKAT-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Gill arch TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.517 Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.471 posteroventral (inferior) parietal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.4485 KYO1 DepMap CRISPR Gene Dependency 1.0 3.58813 ZNF768 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.5323 GTEX-WFG8-1926-SM-4LVM1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.25751 urinary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.158778 Glandular epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.014 Hrd1p ubiquitin ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.51 NP2 DepMap CRISPR Gene Dependency 1.0 2.4825 Eye disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.055 Spermatozoon TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.284 Carbohydrate metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.427 PMC8844187-Table_2.xlsx-prostate-DLX1_DLX1 Rummagene Transcription Factor Associations 2026 1.0 null Apical part of cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.053 7518_RPS27_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.01427 GSE197850_4_v_0_glucagon_human RummaGEO Drug Perturbation Signatures 1.0 null substantia nigra, pars reticulata, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.868391 least GeneRIF Biological Term Annotations 1.0 null SET2 CCLE Cell Line Gene Expression Profiles 1.0 1.51751 Mesothelioma_MESO_TCGA-NQ-A638-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Collecting duct TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.991 primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.29177 Aquaporin-mediated transport Reactome Pathways 2014 1.0 null EJM DepMap CRISPR Gene Dependency 1.0 4.73877 SNU349 DepMap CRISPR Gene Dependency 1.0 2.08649 CSK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41016 lysosomal storage disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.171785 GTEX-UPK5-0006-SM-3GAD8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09939 2545_EIF3B_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.00002 periaqueductal gray substance, ventral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.845407 GTEX-SSA3-0005-SM-32QOT GTEx Tissue Sample Gene Expression Profiles 1.0 1.38031 SIRT6 ENCODE Transcription Factor Targets 1.0 null CMK115 CCLE Cell Line Gene Expression Profiles 1.0 1.61076 disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042789 Respiratory system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.031 PIK3IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67045 496100390_PCx_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.23571 GTEX-RNOR-0005-SM-2TF4Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.04519 primary motor cortex (area M1, area 4)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.839604 TYK-NU.CP-R Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.914316 NANOG-20526341-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.594853 Burning Sensation DisGeNET Gene-Phenotype Associations 1.0 null 9682_UTP15_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.72953 Acute Myeloid Leukemia_LAML_TCGA-AB-2871-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null caudal presubiculum (postsubiculum) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.834791 H3K27me3_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SLC22A17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64929 Gastric gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.259 GTEX-X4LF-0006-SM-3NMCO GTEx Tissue Sample Gene Expression Profiles 1.0 1.88641 IZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.975069 unveiled GeneRIF Biological Term Annotations 1.0 null GTEX-PSDG-0005-SM-3GADC GTEx Tissue Sample Gene Expression Profiles 1.0 0.933423 EZH2_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null colon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05988 RASSF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15223 pineal body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.40116 Lung squamous cell carcinoma_LUSC_TCGA-85-8072-01A-31R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lens epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.264011 CTCF_cardiac fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null apical part of cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.63544 E2F6 ENCODE Transcription Factor Targets 1.0 null biological regulation GO Biological Process Annotations 2015 1.0 null H3K27me3_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF572 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23744 CCDC22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28801 GTEX-X8HC-0006-SM-46MV6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.64598 POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OACP4C COSMIC Cell Line Gene CNV Profiles 1.0 2.3178 HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.831401 MPPE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59246 Lung squamous cell carcinoma_LUSC_TCGA-43-7657-01A-31R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null alimentary canal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-S33H-0126-SM-4AD62 GTEx Tissue Sample Gene Expression Profiles 1.0 0.928169 sense organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.107608 JUNB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29946 Renal proximal tubule cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.984 MAF::NFE2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.0193 TFEC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.0135 Perturb_8806_KD_SON_SRP279434 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE158632_3_v_4_oxyquinoline_human RummaGEO Drug Perturbation Signatures 1.0 null 7499_RPS11_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.518833 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.621024 midbrain reticular formation Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.997421 SAMD4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23147 TBP ENCODE Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8204-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HEXB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.3704 GSE158182_5_v_0_pnpla3_human RummaGEO Gene Perturbation Signatures 1.0 null selective GeneRIF Biological Term Annotations 1.0 null ML1 CCLE Cell Line Gene Expression Profiles -1.0 -2.21722 2105_DDX18_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.781774 7461_RPL34_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.738269 NCIH1568 DepMap CRISPR Gene Dependency 1.0 2.0976 Breast disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.14 HCC70 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.657234 GSE159678_6_v_2_chloroquine_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PX3G-0926-SM-48U12 GTEx Tissue Sample Gene Expression Profiles 1.0 0.961758 apical plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.831384 GP5D COSMIC Cell Line Gene Mutation Profiles 1.0 null Cerebral Amyloid Angiopathy HuGE Navigator Gene-Phenotype Associations 1.0 null 2124_DDX47_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.680262 Visceral mass TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.913 Jejunal mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.237 rectum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.06505 PMC11848109-mmc7.xlsx-MR_sig_SNP_-_gene_expression-Unnamed_1_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null FAAP24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90451 SG in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.825083 exclusively GeneRIF Biological Term Annotations 1.0 null polymorphic layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.39395 DNLZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94159 intrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null GTEX-U8XE-0005-SM-3DB8I GTEx Tissue Sample Gene Expression Profiles 1.0 1.06912 Gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.409 GTEX-WHPG-0006-SM-3NMBV GTEx Tissue Sample Gene Expression Profiles 1.0 1.63536 layer V of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07884 GTEX-X4EP-0005-SM-3P5ZE GTEx Tissue Sample Gene Expression Profiles 1.0 0.956985 endocrine GeneRIF Biological Term Annotations 1.0 null URGCP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5021 membrane LOCATE Predicted Protein Localization Annotations 1.0 null MAGED1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22136 NCIH2030 DepMap CRISPR Gene Dependency 1.0 2.60092 transport GO Biological Process Annotations 2015 1.0 null gonad TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.074841 RRAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.10328 anterior (rostral) cingulate (medial prefrontal) cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.969635 SW684 COSMIC Cell Line Gene Mutation Profiles 1.0 null Mesothelioma_MESO_TCGA-MQ-A4LI-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cell periphery COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.638434 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I5-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 7476_RPL6_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.834179 TRMT61B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06346 integral component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.433012 Lipid storage disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.088 NCI-H1770 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12148 GATA4-25053715-YYC3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null organic hydroxy compound transport GO Biological Process Annotations 2015 1.0 null H3K27me3_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HAX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58128 Smooth endoplasmic reticulum lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.028 lateral habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.854258 characteristic GeneRIF Biological Term Annotations 1.0 null LTA4H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0555 GSE205163,GSE205164_5_v_8_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null Lamina epithelialis mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.267 EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.63966 Small intestine TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SLC35E2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99882 dorsal thalamus_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.30102 intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.338707 7453_RPL26_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.00742 TEAD4_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZR751 CCLE Cell Line Gene CNV Profiles 1.0 1.33687 Lung squamous cell carcinoma_LUSC_TCGA-34-5240-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-DX-AB2J-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null vestibular nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.47825 brain ischemia; cardiovascular diseases; coronary disease; stroke GAD Gene-Disease Associations 1.0 null impaired renal function disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.561392 eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ME-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.37198 H3K4me3_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null inferior frontal gyrus, orbital part, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.844531 H3K27me3_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7477_RPL7A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.11876 insertion GeneRIF Biological Term Annotations 1.0 null homeostatic process GO Biological Process Annotations 2015 1.0 null Peribacteroid membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.21 anterior orbital gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.78306 NDUFA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01001 PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ion transport GO Biological Process Annotations 2015 1.0 null SARS-dORF6_0Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.57922 Ciliary pocket membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.566 rostral (anterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.67288 Fox-Fordyce disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.133 GTEX-REY6-0005-SM-2TF54 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04164 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A680-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78688 7526_RPS4X_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.03268 6215_PELP1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.946786 NCOR1 ENCODE Transcription Factor Targets 1.0 null KMS-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13666 Lung adenocarcinoma_LUAD_TCGA-49-6761-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE234289_4_v_2_rfx6_human RummaGEO Gene Perturbation Signatures 1.0 null Lens TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.364 9482_UBA52_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.661163 PMC10201771-12864_2023_9385_MOESM1_ESM.xlsx-ST18-Unnamed_1_ST18 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-POMQ-0526-SM-3GADD GTEx Tissue Sample Gene Expression Profiles 1.0 1.30072 Liver cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.031 GTEX-TML8-0326-SM-4GICN GTEx Tissue Sample Gene Expression Profiles 1.0 1.10494 Rectal sac TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.968 epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.754124 SLC11A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49003 Uterine Carcinosarcoma_UCS_TCGA-N5-A59E-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Thoracic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.14 CTCF_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE203060_0_v_1_kdm4c_human RummaGEO Gene Perturbation Signatures 1.0 null particularly GeneRIF Biological Term Annotations 1.0 null paracentral lobule, anterior part, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.60971 POLR2AphosphoS5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Duodenal gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.202 NKX2-5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4177 ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7684-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PSMG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60783 Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6WZ-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null P3HR1 CCLE Cell Line Gene Expression Profiles 1.0 1.36469 GSE205163,GSE205164_1_v_4_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null H3K27me3_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A76L-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE203060_0_v_2_kdm4c_human RummaGEO Gene Perturbation Signatures 1.0 null GSE216273,GSE216292_0_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE178714_5_v_7_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null 496100426_PCx_no dementia_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 5.01938 Perturb_4867_KO_HES1/NEUROG3_ERP110708 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.82233 GTEX-U3ZH-0005-SM-3DB72 GTEx Tissue Sample Gene Expression Profiles 1.0 1.40045 Arthritis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 GTEX-SNMC-0006-SM-2XCFE GTEx Tissue Sample Gene Expression Profiles 1.0 0.924277 Uroepithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.749 HCC2218 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07155 7450_RPL23_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.854709 MAFF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.0771 YMB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.74075 TP63-30713093-EPITHELIAL-HUMAN-TONGUE-SCC ChEA Transcription Factor Targets 2022 1.0 null primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.77141 urea transmembrane transport GO Biological Process Annotations 2015 1.0 null PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Supplementary_Table_9A_The_effects_of_whole_blood_transcripts_on_COVID-19_severity_with_suggestive_Mendelian_randomization_evidence_P_0_05_using_Genomicc_data_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null NCIH23 DepMap CRISPR Gene Dependency 1.0 4.41332 C3A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.828174 primary auditory cortex (core)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.850138 MC116 CCLE Cell Line Gene Expression Profiles 1.0 1.37932 ZNF416 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.3768 USF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-7966-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null plasma membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.165463 MDAMB157 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.23981 Respiratory system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 male reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058072 Urea CTD Gene-Chemical Interactions 1.0 null SF126 CCLE Cell Line Gene CNV Profiles -1.0 -2.78815 Edema HuGE Navigator Gene-Phenotype Associations 1.0 null Hand Eczema DisGeNET Gene-Disease Associations 1.0 null GTEX-QLQW-1026-SM-447A9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.824402 TFEB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.7806 taste bud TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.452584 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.27772 GTEX-P4PQ-0526-SM-2HMKR GTEx Tissue Sample Gene Expression Profiles 1.0 1.37264 ELF1 ENCODE Transcription Factor Targets 1.0 null GTEX-QDVJ-0926-SM-2I5FU GTEx Tissue Sample Gene Expression Profiles 1.0 1.36333 HUPT4 CCLE Cell Line Gene CNV Profiles -1.0 -1.7742 CAMA1 CCLE Cell Line Gene CNV Profiles 1.0 1.36596 TTYH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64705 intestinal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.061115 PMC10170086-41598_2023_34519_MOESM6_ESM.xlsx-Sheet3-The_overlapping_genes_between_significantly_co-expressed_genes_and_significantly_differentially_expressed_genes_of_BARX2_in_LIHC_BARX2 Rummagene Transcription Factor Associations 2026 1.0 null Sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.16 GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles 1.0 1.34264 H3K27me3_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NMB DepMap CRISPR Gene Dependency 1.0 4.57306 496100351_FWM_no dementia_TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.34736 CP in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.69253 orbital frontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.33621 HG2+ DGIdb Drug Targets 2026 1.0 5.2932 small intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.655836 IZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.899678 WDR75 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22282 GTEX-OIZH-0005-SM-2HMJN GTEx Tissue Sample Gene Expression Profiles 1.0 2.02554 HCT15 DepMap CRISPR Gene Dependency 1.0 2.99728 VZ in postamygdaloid region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.11627 MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8015-01B-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-8076-01A-31R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null jejunal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.837833 NCIH211 CCLE Cell Line Gene CNV Profiles -1.0 -2.12373 CEBPD_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZN-0126-SM-4DXUM GTEx Tissue Sample Gene Expression Profiles 1.0 0.864912 GSE162892_4_v_1_isox_human RummaGEO Drug Perturbation Signatures -1.0 null MAFA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.5065 outer SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.943125 647V DepMap CRISPR Gene Dependency 1.0 3.79207 Serous acinar cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.893 HS 578T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1858 female reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053088 7480_RPL8_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.936333 fluid transport GO Biological Process Annotations 2025 1.0 null REST_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUZC-0005-SM-4BOQ8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.5456 ZNF143 ENCODE Transcription Factor Targets 1.0 null MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA3 JASPAR Predicted Transcription Factor Targets 1.0 null fallopiantube_8d HPA Tissue Sample Gene Expression Profiles 1.0 1.26231 PMC10933424-41420_2024_1903_MOESM1_ESM.pdf-2-PRDM13_PRDM13 Rummagene Transcription Factor Associations 2026 1.0 null 7478_RPL7L1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.08005 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A677-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K79me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null contents GeneRIF Biological Term Annotations 1.0 null Intestinal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.193 structurally GeneRIF Biological Term Annotations 1.0 null disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.043155 GTEX-U4B1-0006-SM-3DB8E GTEx Tissue Sample Gene Expression Profiles 1.0 1.05146 GSE201309_1_v_2_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null posterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.17383 4953_MED30_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.657747 GTEX-UTHO-0006-SM-3NMCC GTEx Tissue Sample Gene Expression Profiles 1.0 1.37459 496100389_HIP_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.52321 eye TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.115116 PMC9859043-elife-78421-supp9.xlsx-LHX8_P-Gene_symbol_LHX8 Rummagene Transcription Factor Associations 2026 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-8626-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHAGOK1 CCLE Cell Line Gene CNV Profiles 1.0 1.59772 amino GeneRIF Biological Term Annotations 1.0 null embryonic structure TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051933 496100453_HIP_possible Alzheimer's disease_no TBI_88_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 5.95794 primary motor cortex (area M1, area 4)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.911829 UBTF ENCODE Transcription Factor Targets 1.0 null 5733_NOL11_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.833855 GTEX-V1D1-0006-SM-3NMCE GTEx Tissue Sample Gene Expression Profiles 1.0 1.49629 adenocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056414 PMC8390401-12094_2021_2621_MOESM2_ESM.xls-S4-Supplemental_Table_S4_Differentially_expressed_genes_between_cases_with_G-CSF-induced_pY-STAT3_DMFI_1_5_STAT3_Low_v_DMFI_1_5_STAT3_High_STAT3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QDVN-0726-SM-4B64L GTEx Tissue Sample Gene Expression Profiles 1.0 1.15487 GTEX-WFON-0426-SM-3GIL4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.879872 intestinal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.698625 NAV2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76978 lateral hypothalamic area, anterior part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11981 7466_RPL36_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.851051 DOR 13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05193 PMC6420765-12864_2019_5550_MOESM5_ESM.xlsx-D4_vs_D9-Unnamed_1_CENPX Rummagene Transcription Factor Associations 2026 1.0 null GATA2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPVG-0006-SM-4B65Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.934487 ZNF652 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6609 hsa-miR-583 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 K562 CCLE Cell Line Gene Expression Profiles 1.0 1.59992 HACD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83425 Acrosomal vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.175 7463_RPL35_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.49844 U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.867458 fluid transport GO Biological Process Annotations 2023 1.0 null posterior (caudal) superior temporal cortex (area 22c)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.10725 colonic cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063145 Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A4JJ-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OIZH-0926-SM-48TBR GTEx Tissue Sample Gene Expression Profiles 1.0 0.953607 Sperm plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.169 HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU81 CCLE Cell Line Gene Expression Profiles -1.0 -2.52756 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M9-01A-23R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1623 COSMIC Cell Line Gene CNV Profiles 1.0 2.3178 intercalated nucleus of medulla Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.52271 SW 480 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0863 layer II of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.38808 water transmembrane transporter activity GO Molecular Function Annotations 2025 1.0 null 7443_RPL18_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.801027 PRPF19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.28571 colitis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.246098 MXI1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null rumen TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.355198 GSE131649_4_v_9_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-Q2AI-0526-SM-2I3EJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.04915 CEBPB ENCODE Transcription Factor Targets 1.0 null LHX9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04555 CSRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75291 TAL1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE131649_4_v_1_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null 5637 COSMIC Cell Line Gene Mutation Profiles 1.0 null SOX2_Deficiency_GDS4853_322_human_AZ-521 gastric cancer (GC) cell line - 24 Hours GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A71E-01A-31R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ETV5::DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.0268 CTCF ENCODE Transcription Factor Targets 1.0 null ZNF648 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90654 Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PZ-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null respiratory system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 Skin Cutaneous Melanoma_SKCM_TCGA-GF-A6C9-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE214335_1_v_0_sox9_human RummaGEO Gene Perturbation Signatures 1.0 null bacteroid-containing symbiosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.207 H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TP63-23658742-EP156T-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Skin cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.023 Renal medulla TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.878 GTEX-OOBK-0005-SM-2YUMG GTEx Tissue Sample Gene Expression Profiles 1.0 1.29467 disease GWASdb SNP-Disease Associations 1.0 0.027586 9816_WDR36_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.628237 cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.68515 5365_MYBBP1A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.762537 hsa-miR-3125 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09744 GSE203329_2_v_3_mettl5_human RummaGEO Gene Perturbation Signatures 1.0 null renal tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.307167 BT16 DepMap CRISPR Gene Dependency 1.0 2.84644 Serous cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.139 GSE150072,GSE169209_4_v_11_qser1_human RummaGEO Gene Perturbation Signatures 1.0 null Colonocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.809 Pyloric stomach TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.922 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7862-01A-21R-2232-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null caco-2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.33744 H3K27me3_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A59R-11A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EZH2 ENCODE Transcription Factor Targets 1.0 null Blood-platelet Tabula Sapiens Gene-Cell Associations 1.0 0.533388 Parotid acinar cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.845 duodenum_4c HPA Tissue Sample Gene Expression Profiles 1.0 1.78551 MYC_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null 2132_DDX56_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.774425 GTEX-Q2AH-0426-SM-2I3EP GTEx Tissue Sample Gene Expression Profiles 1.0 0.9703 Cardiovascular system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.711 Lung adenocarcinoma_LUAD_TCGA-93-7348-01A-21R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAD21_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ2-0006-SM-33HBH GTEx Tissue Sample Gene Expression Profiles 1.0 1.17753 7536_RPS6_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.759075 ZNF142 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06652 deltaEF1 MotifMap Predicted Transcription Factor Targets 1.0 null 7577_RSL24D1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.549045 GTEX-U8XE-1426-SM-3DB8Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.944564 hsa-miR-335-5p MiRTarBase microRNA Targets 1.0 null Musculoskeletal system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 HCC95 CCLE Cell Line Gene CNV Profiles -1.0 -1.60205 MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4 ENCODE Transcription Factor Targets 1.0 null GTEX-XAJ8-1326-SM-47JYT GTEx Tissue Sample Gene Expression Profiles 1.0 0.891469 GSE155031_5_v_0_dextran_human RummaGEO Drug Perturbation Signatures -1.0 null 7506_RPS17_ENST00000330339.7 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.54404 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02527 HaCaT cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.918 hippocampus (hippocampal formation)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -3.37706 20035825-Table3 GeneSigDB Published Gene Signatures 1.0 null Apicolateral plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.636 primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00866 Specific developmental disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04075 HUNS1 CCLE Cell Line Gene Expression Profiles 1.0 1.49606 H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KARPAS299 CCLE Cell Line Gene CNV Profiles -1.0 -2.69144 1365_CD3EAP_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.720877 1004_C17ORF58_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.576316 hsa-miR-943 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Skin Abnormalities CTD Gene-Disease Associations 1.0 1.07625 Prostate adenocarcinoma_PRAD_TCGA-HC-7231-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H3K27me3_H7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular chemical homeostasis GO Biological Process Annotations 2015 1.0 null hsa-miR-3916 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 E2F4_02_200 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.61494 GTEX-PW2O-0126-SM-48TC8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.878106 GTEX-UJMC-0726-SM-3GADX GTEx Tissue Sample Gene Expression Profiles 1.0 0.967673 GTEX-S33H-0005-SM-2XCAL GTEx Tissue Sample Gene Expression Profiles 1.0 1.27484 apical complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.551838 HCC2157 COSMIC Cell Line Gene CNV Profiles 1.0 2.3178 Acrosomal membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.253 GATA4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.9067 Edinger-Westphal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.98563 KMS11 CCLE Cell Line Gene CNV Profiles 1.0 1.54461 BHLHE40 ENCODE Transcription Factor Targets 1.0 null 496100595_PCx_probable Alzheimer's disease_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.20222 HDAC2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer IIIu of area 35r Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.8926 Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3Z9-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MZ7-MEL COSMIC Cell Line Gene Mutation Profiles 1.0 null striatum_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.19683 providing GeneRIF Biological Term Annotations 1.0 null H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Epididymal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.093 hippocampus (hippocampal formation)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.43072 IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01936 ZNF284 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96833 Heart disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.711 inferior rostral gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.868491 Exodermis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.302 7460_RPL32_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.808321 Atrial fibrillation DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.711 2790_EXOSC3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.590182 small intestine GTEx Tissue Gene Expression Profiles 1.0 1.0447 Spinal cord disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.063 GSE205163,GSE205164_3_v_4_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null uterine endometrium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.301398 Pancreas disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.048 urea transmembrane transporter activity GO Molecular Function Annotations 2023 1.0 null Pompholyx DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.03 water channel activity GO Molecular Function Annotations 2015 1.0 null 496100494_HIP_no dementia_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.12153 GSE224547_1_v_0_cftr_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-SSA3-0126-SM-32QPU GTEx Tissue Sample Gene Expression Profiles 1.0 0.874802 Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-A5NI-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferior occipital gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02982 GTEX-V955-0005-SM-3P5ZC GTEx Tissue Sample Gene Expression Profiles 1.0 1.5681 III, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.891438 PPP2R5E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06543 HSFY2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17109 oculomotor nuclear complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.76373 JUND ENCODE Transcription Factor Targets 1.0 null HCC1171 CCLE Cell Line Gene CNV Profiles 1.0 2.08335 hsa-miR-3150a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 ES8 DepMap CRISPR Gene Dependency 1.0 3.59473 901_BRIX1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.590203