association	dataset	threshold value	standardized value
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_PF-573228_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188488
BRD-K10010414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15268
A549_UNC1999_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149604
GSE166920_6_v_8_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Valproic acid sodium salt_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0221772
GSE250560_1_v_0_foxo1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.6379
A549_SRT1720 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0279425
GSE195503_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213650_3_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ARH77	DepMap CRISPR Gene Dependency	1.0	2.04753
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
BE-31-XV38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292897
BRD-K12343830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01977
BRD-K62358193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13355
BRD-K66408914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37082
GSE182854_2_v_0_sirt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_ABT-737_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131066
BRD-K85627183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49537
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259689
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Trametinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00975529
BRD-K25649596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25024
BRD-K70532227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51814
MCF7_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183767
AE-85-KE62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20007
A549_Ofloxacin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017711
BRD-K54351451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11867
K562_Tranylcypromine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156384
K562_Obatoclax Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190631
BRD-K43271856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04381
GSE121824,GSE121826_0_v_3_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_5_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
HUH7_LIVER	CCLE Cell Line Proteomics	1.0	3.48965
GSE128730_4_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K86872145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01309
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAGEB17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42601
iodoquinol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76853
MCF7_AC480_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0105363
BRD-K67319345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94825
BRD-K81888673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36883
BRD-K17040651	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94646
K562_KW-2449_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184607
GSE232714_0_v_1_raver1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PRKAB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8986
GSE166004_1_v_0_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NR1I2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16972
H4C3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40225
GSE77108_0_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.44628
BRD-K39020351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19984
PIGU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29211
BRD-K99971319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58633
GSE182680,GSE182683_5_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE248887_0_v_1_dkk1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K77624847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89797
A549_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194456
K562_EED226_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157414
BRD-A17831693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1325
GSE249544,GSE249637_6_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_SRT2104_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148311
BRD-K38706080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62183
QF-71-QI30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.560146
BRD-K60713831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04967
A549_G007-LK_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.02474
BRD-K28874552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48034
A549_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140022
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K40103182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07195
BRD-A71590475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13742
MCF7_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142147
BRD-K18253469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10259
A549_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0259031
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9385264-NIHMS1828071-supplement-8.xlsx-AR-gene_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE249544,GSE249637_9_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K70183558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05881
PSMG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3253
AC-28-RT00_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.328391
A549_Zileuton_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155017
A549_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137421
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.569847
A549_Luminespib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0106779
CISD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36536
A549_Temsirolimus_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232098
BRD-A64761364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08509
MCF7_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135357
BRD-K00347903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22841
BRD-K19457629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39223
FAM193B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19241
PMC13137955-ijbsv22p4243s2.xlsx-Sheet1-hTFtarget_E2F3_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
PSMD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29962
NCIH2004RT	DepMap CRISPR Gene Dependency	1.0	4.84125
A549_PJ34_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180313
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE81193_1_v_5_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_XAV-939_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179118
A549_SNS-314 Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209205
PMC4815041-NIHMS715090-supplement-Supplementary_Table_10.xlsx-CCF_DP_clustering-Hugo_Symbol_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182680,GSE182683_5_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-421_ChIP-Seq_H3K9me1_2_AR_differential_expression_upon_KDM3A_or_AR_knockdown_AR	Rummagene Transcription Factor Associations 2026	1.0	null
FOXC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.6866
A549_Fasudil_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133417
TET1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11683
GSE143406_1_v_0_carfilzomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Phagocytic cup	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.902
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239906
A549_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165561
CDH4-35650610-MESC-MOUSE-STEM-AUTISM	ChEA Transcription Factor Targets 2022	1.0	null
A549_Abexinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018024
BRD-K56015010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44645
CRCGN015_HEPG2_48H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09039
A549_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179328
GSE220520_6_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.580259
A549_AC480_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0263378
regulation of organelle organization	GO Biological Process Annotations 2023	1.0	null
MCF7_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154626
BRD-K24025166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12151
A549_A-366_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152288
BRD-K39029546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2685
BRD-K28619632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02505
A549_Thiotepa_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151043
496100472_PCx_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.34782
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.48117
A549_Selisistat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150164
K562_A-366_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170749
BRD-K70652938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15926
BRD-K74789550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16408
BRD-K74968522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71576
BRD-K64537490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24121
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.875
BRD-K92379545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11665
GSE62974_1_v_0_epas1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-A19912945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90437
Breast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.442
BRD-K67525206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25133
GSE238116_1_v_0_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Bosutinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130869
A549_BMS-911543_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.026137
A549_SB431542_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014489
A549_Bisindolylmaleimide IX_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016194
H2BC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06153
GSE139120_1_v_0_urod_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Peroxisomal importomer complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.035
RPL24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40852
BRD-K73048554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45615
MCF7_Abexinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132323
BRD-K47482563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13494
BRD-K16468319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3037
GSE229973_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112365_0_v_1_sirt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BD-60-DR81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250503
A549_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169894
BRD-K54247106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07979
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6627
GSE119978,GSE180930_3_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CB-38-AW77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294665
MCF7_Meprednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216481
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K60076175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00596
GSE48812_8_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K19106745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11745
TD-69-UA90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214803
GSE196699_2_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155666
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.445398
GSE190384,GSE190386_6_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_SRT1720 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172568
A549_JQ1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191728
A549_ENMD-2076 L-Tartaric acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0260321
BRD-K00463020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06314
MCF7_Cyclocytidine HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212392
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.299427
PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Gene_Name_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Rucaparib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201227
A549_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190041
SKNEP1	DepMap CRISPR Gene Dependency	1.0	2.38815
BRD-K17384993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6334
anthraquinone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16876
A549_Aurora A Inhibitor I_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136681
GSE164874_5_v_14_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SEMK2	DepMap CRISPR Gene Dependency	1.0	3.54456
BRD-K36320220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02512
GSE113221,GSE113968_6_v_1_prdm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE155162,GSE155169_1_v_2_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TIMM23B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74973
DA-10-ZX00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217015
BRD-K50004365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62679
GSE197686,GSE197688_2_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE159678_6_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KMS26	DepMap CRISPR Gene Dependency	1.0	2.38628
BRD-K16966765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14498
MCF7_PF-3845_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0258996
K562_Tofacitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163676
UMUC6	DepMap CRISPR Gene Dependency	1.0	3.9923
GSE140200_1_v_3_trim59_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Relugolix_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0153699
USP49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19087
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231114
ZNF610	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.9648
K562_Obatoclax Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169311
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.5114
PMC12224929-ADVS-12-2416784-s006.xlsx-DEG_circGLIS3_KD-Unnamed_6_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Heart disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.172
A549_JNJ-26854165_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200286
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259194
GSE196699_2_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K48213854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.46591
GSE235066_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K05639803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16833
GSE247775_1_v_0_tmprss2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Intracellular anatomical structure	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
MCF7_XAV-939_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216587
myclobutanil	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45571
GSE242199_2_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K65265098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12861
BRD-K80897487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24281
A549_Daphnetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194435
A549_AG-14361_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154024
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D3REFED24h_1198_AR-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K51398207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4941
GRHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6507
BRD-K56223790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1299
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.380542
BRD-K76904668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50539
Semimembranosus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.656
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8733
A549_PF-3845_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238068
PARP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56103
AB-21-VE32_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250078
K562_Streptozotocin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173433
A549_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176478
MCF7_MC1568_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130858
BRD-K80306055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07578
A549_Dacinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165582
GSE217873_1_v_0_nusap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
KP4_PANCREAS	CCLE Cell Line Proteomics	1.0	2.94981
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Tanespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193456
BRD-K99380757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63314
BRD-K04363234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.054
BRD-K95768123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26381
MCF7_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136022
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.2125
BRD-K21203629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00356
BRD-K37062347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17359
MCF7_Amisulpride_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.033389
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_TGX-221_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136729
A2058_SKIN	CCLE Cell Line Proteomics	1.0	3.01876
K562_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163388
BRD-K77535986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28752
BRD-K21327356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19773
BRD-K70924576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20847
OCILY18	DepMap CRISPR Gene Dependency	1.0	5.95089
Charcot-Marie-Tooth disease type 4B1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
GSE229914_1_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2511
BRD-K24752397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23754
GSE81193_1_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216352,GSE216354_1_v_0_keap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_WP1066_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0211342
CRCGN014_HEPG2_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27782
PABPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10502
PCF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41587
GC-02-TV70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259182
A549_IOX2_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152512
BRD-K81104218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18222
GSE130217_5_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
AC-80-DI95_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334197
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182847
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.58925
BRD-K28165728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02852
A549_BMS-911543_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203389
CH157MN	DepMap CRISPR Gene Dependency	1.0	3.01804
A549_Rigosertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0267674
A549_Barasertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013994
SIK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00175
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_SRT2104_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191483
HNF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.2432
EE-98-PF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.71277
ASIC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02197
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.402982
GSE57871_5_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE231799_3_v_5_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.825358
CA-10-RU23_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.35018
A549_Tranylcypromine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0231526
MCF7_Curcumin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014536
BRD-K48255349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88975
GSE103068_0_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PPP1R3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96708
BRD-K95501793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14893
GSE165122_0_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_INO-1001_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0266348
Nfe2l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.343
BRD-K27256143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19591
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265318
GSE201217_4_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB8OS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07238
PMC5444746-oncotarget-08-30328-s002.xlsx-SI01_ChIPSeq_H3K9me_AR-Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Prednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145026
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.082
BRD-K82314391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31405
MCF7_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188762
MM127	DepMap CRISPR Gene Dependency	1.0	2.93254
Body Height	DisGeNET Gene-Phenotype Associations	1.0	null
STAT1::STAT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.4065
PMC6484770-41388_2018_602_MOESM5_ESM.xlsx-down_P53_vs_con-Unnamed_1_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
TLCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86508
abnormal chorion morphology	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K21000135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2996
Intelligence	DisGeNET Gene-Phenotype Associations	1.0	null
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.3241
BRD-K95569142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48735
HA1E	DepMap CRISPR Gene Dependency	1.0	2.72433
AP2A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23408
CRCGN015_MCF10A.TP53.M_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29311
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251281
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.9585
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300819
SERF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14605
FOXD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.7451
BRD-K61439686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11029
A549_Bisindolylmaleimide IX_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148474
A549_Iniparib_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123938
BRD-K32079609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51022
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.526491
BRD-K47028303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05325
GSE139975_3_v_0_rnf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K68890376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15227
MCF7_Sodium Phenylbutyrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185818
A549_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0230909
K562_Glesatinib(MGCD265)_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163563
BRD-K89811208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91973
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_YM155_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168127
BRD-K25045770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27892
GSE239844_7_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100593_TCx_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.36292
EB-09-JJ93_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.280852
GSE128232,GSE128233_1_v_0_phf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_SRT2104_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153266
BRD-A06232236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49901
A549_Dasatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224375
IF-03-OL58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21926
HDAC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07765
OC-10-FB51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314152
MCF7_Danusertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0223617
Hoxa11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.5994
BRD-K83586473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41099
GSE140651,GSE140653_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12405
ZBED2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0224
GB-73-QS80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260866
DC-47-KV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.724001
GSE114992,GSE114993_9_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_CEP-33779_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160344
HCC44_LUNG	CCLE Cell Line Proteomics	1.0	2.04008
HSC39	DepMap CRISPR Gene Dependency	1.0	3.83958
AD-34-TG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246653
BRD-K66909712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70509
A549_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0231145
MCF7_Cimetidine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164413
BRD-K17209411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2298
GSE216147_0_v_1_rbm20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Andarine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163423
BRD-K24494475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03423
Atrial fibrillation	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.9
BRD-K76482408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02183
A549_Ellagic acid_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179595
Paroxysmal Atrial Fibrillation	DisGeNET Gene-Disease Associations	1.0	null
SUM1315MO2	DepMap CRISPR Gene Dependency	1.0	2.93065
DUXA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.9807
Meckel syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.286
BRD-K33539506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13487
BRD-K76389813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08325
BRD-K36003376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83946
BRD-K85392247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24191
MCF7_Pelitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145899
GSE171837_1_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Rd	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.786
BRD-K71561082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12369
BRD-K72424071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08156
MCF7_AZD1480_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01854
Coronary artery calcification	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.539794
BRD-K98095706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11449
CRCGN011_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.28872
GSE168171,GSE168173_0_v_1_ddx41_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247624
BRD-K52428486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77672
GSE77108_8_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K08190558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20026
A549_MLN8054_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180329
Stat5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.5591
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.7496
Golgi membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.771
BRD-K67783817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6887
496100382_PCx_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.05384
BRD-K39153737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16092
A549_PHA-680632_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156484
GSE242199_9_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Costunolide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0106704
A549_RG108_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018235
K562_Rucaparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0287486
A549_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157729
MCF7_PD98059_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134134
MN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0951
BRD-K24312231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01615
GSE225869_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K71015709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.49908
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.415954
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.490737
MCF7_Temsirolimus_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130431
GSE213588_9_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Ellagic acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146669
GSE135030_11_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TFCP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.216
MCF7_Barasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161439
OE-21 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.917
MCF7_Entinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00804168
GSE165704_0_v_1_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Anacardic Acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194096
CRCGN016_MCF10A.WT.HP_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75554
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.520849
BC-54-ON71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.338404
Cardiovascular system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.172
BRD-K72125659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30363
ZBTB32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08108
BRD-K03341571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20033
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE233679_5_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Fasudil_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166878
BRD-K05118861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.35381
A549_Tucidinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0248037
Multilymphoid progenitor cell_Umbilical cord blood_Human	CellMarker Gene-Cell Type Associations	1.0	null
A549_Entinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129382
A549_Alisertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190038
NCIH441_LUNG	CCLE Cell Line Proteomics	1.0	3.39214
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.302893
A549_GSK-LSD1 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165588
BRD-K26232524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80989
CORL311	DepMap CRISPR Gene Dependency	1.0	3.77783
K562_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181296
A549_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161098
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223268
A549_Entacapone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223981
MCF7_Triamcinolone Acetonide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121109
GSE149124,GSE149128_2_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.082
GSE140200_1_v_0_trim59_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NF-kappaB p50/p65 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.504
TRIM65	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40383
chloroxylenol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5782
COPS9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26354
AB-21-VE32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.34842
TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.172
A549_Altretamine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0235061
K562_Pracinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183254
K562_MK-0752_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174281
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.438167
A549_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158807
BRD-K67344728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20754
A549_Resminostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232524
GSE158834_1_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF568	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06999
BRD-K93956318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84802
BRD-K56759808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60787
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.376973
MCF7_UNC0379_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0259193
CRCGN008_HEPG2_24H:B04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27012
Atrial Fibrillation	DisGeNET Gene-Disease Associations	1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.799918
A549_Divalproex Sodium_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153009
Cognitive ability (MTAG)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.852288
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8281
BRD-K03654379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03191
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336212
A549_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0260777
BRD-K98578493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0853
BRD-K61092554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24964
BRD-K39752756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26774
BRD-K76067434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33654
SNU-449 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.911
A549_G007-LK_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127742
MCF7_Bosutinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129648
K562_Vandetanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196678
BRD-K52833964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47397
BRD-K31030467	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75328
DA-58-LZ09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226561
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132957
DNM1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10742
A549_S3I-201_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.020299
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-10q22_1_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_BRD4770_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147867
PMC6344081-elife-40364-supp5.xlsx-PLZF_peaks_H3K27Ac_unchanged-Unnamed_10_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
496100640_PCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.08512
A549_Azacitidine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00991606
BRD-K38750802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88645
BRD-K48764596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45243
GSE77108_8_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SW480_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.66399
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7825
CRCGN011_HEPG2_24H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0674
A549_Panobinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00842123
GSE216147_2_v_1_rbm20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198165,GSE198166_6_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A43164341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6975
nystatin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26717
K562_CUDC-101_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172662
GSE206729_5_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012633
A549_Luminespib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195628
embryonic lethality during organogenesis, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
A549_Decitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175504
A549_Pracinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0105135
BRD-K41690760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14903
GSE164463_4_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K06577881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.53779
UBE2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14002
Early endosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.73
TCF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01486
MCF7_Barasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149775
BRD-K75775113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42963
CRCGN017_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5243
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.34346
A549_Roscovitine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204649
SIPA1L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18847
A549_BMS-265246_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0228967
496100408_PCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.06872
BRD-K28912195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33621
K562_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204935
BRD-K13719101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12809
T24	DepMap CRISPR Gene Dependency	1.0	4.12598
BRD-K48782834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03606
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19911
BC-61-BE07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218855
PMC7429792-40104_2020_487_MOESM3_ESM.xlsx-MSC_enriched_miRNA_target-NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K77354492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15037
hand, foot and mouth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.495
FOSL1-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN011_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.26375
MLH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35249
496100622_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.0634
496100477_HIP_no dementia_TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.4637
A549_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207109
BRD-K72098698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47105
MCF7_Costunolide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176883
K562_Curcumin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152992
Uterine endometrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.082
AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE240027,GSE240030_5_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GATC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12176
GSE198165,GSE198166_6_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130401_4_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K69668687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20075
BRD-K31393518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16562
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PROP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.186
BRD-A05456882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0984
Organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
A549_SRT1720 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166159
Crohn's colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.428
BRD-K62692910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04376
BRD-K75551005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21991
GSE233679_14_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Tubastatin A HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0251943
chr10_101798944_G_A_b38	GTEx eQTL 2025	1.0	1.95077
BRD-K55538850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1107
GSE198165,GSE198166_6_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_11_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.587
GSE128730_7_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.29596
SNUC1	DepMap CRISPR Gene Dependency	1.0	3.74143
K562_Carmofur_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170925
BRD-K53971345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1433
BRD-K26461918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02359
BRD-K01045229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7384
Prdm14	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.5364
A549_Tucidinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136658
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.9832
eltanolone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10911
BRD-K75576005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53225
GSE123105,GSE124556_0_v_2_pcf11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Iniparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151792
A549_Mesna_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139687
MCF7_Vandetanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135475
BRD-K89199943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05197
BRD-A20256229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53724
A549_Selisistat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0264429
MITD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15207
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_5_TbID_-biotin_ERM_proteo-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K71631414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02829
MCF7_AG-490_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019213
A549_Ofloxacin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157068
MCF7_Nilotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0203789
CRCGN012_HEPG2_24H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48827
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.6726
JHH6_LIVER	CCLE Cell Line Proteomics	1.0	8.87176
MYD88	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23553
BRD-K88362336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8332
BRD-K74712962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02919
A549_AZD1480_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0251075
GSE109140_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K83946740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07087
BRD-K91423144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30307
K562_JNJ-26854165_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143566
BRD-K75067815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12672
ZNF649	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04724
A549_Trichostatin A_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208201
496100351_FWM_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04855
MCF7_Quercetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0121782
MCF7_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159634
K562_PF-573228_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159565
BRD-K61079130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35595
BRD-K81647747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39531
A549_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193255
CDAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01812
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K72821236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25047
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.60563
MCF7_Lenalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189994
BRD-K13761649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15405
GSE139966_1_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226114,GSE226116_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Alendronate sodium trihydrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177521
GSE223008_6_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BA-84-TD72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336448
BRD-K88281646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03194
CD-90-SN76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245306
BRD-K78119702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50587
K562_TAK-901_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0233638
BRD-K88119862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14767
BRD-K90127324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54932
GSE182680,GSE182683_10_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K86070914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22353
GSE207302,GSE207303_0_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K01266518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68763
Brain - Putamen (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.07113
MCF7_JNJ-26854165_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139126
A549_Celecoxib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.022878
sulfanitran	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34589
SUM cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.518
496100623_PCx_no dementia_TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.11307
increased grip strength	IMPC Knockout Mouse Phenotypes	1.0	null
ZNF135	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.9515
BRD-K62226454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61677
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.1318
TDGF1P3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17636
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.65924
MCF7_Trametinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0100214
BRD-K25177502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96345
GSE210476_11_v_10_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_4_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_S-Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138374
A549_MK-5108_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164099
BRD-K19580273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22703
regulation of organelle organization	GO Biological Process Annotations 2025	1.0	null
A549_MK-0752_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135148
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.502857
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LPCAT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03457
A549_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189341
A549_Bisindolylmaleimide IX_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161405
CRCGN016_MCF10A.TP53.M_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.82833
BRD-K07281036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69193
MCF7_Regorafenib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179304
BRD-K63758740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02076
6980_PYURF_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05504
CRCGN008_HEPG2_24H:A04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2051
BRD-K55814495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34327
bounding membrane of organelle	GO Cellular Component Annotations 2025	1.0	null
Acute flaccid myelitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
A549_SRT1720 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0271152
BRD-K27458941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45103
SUDHL10	DepMap CRISPR Gene Dependency	1.0	6.51027
Intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K92565319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16954
Raw vegetable consumption	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.752288
CRCGN017_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2064
BRD-K42457027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14904
GSE103068_5_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
increased grip strength	MGI Mouse Phenotype Associations 2023	1.0	null
AP1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76853
GSE136894_2_v_3_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Sodium Phenylbutyrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153779
MFE319	DepMap CRISPR Gene Dependency	1.0	6.6992
GSE233679_12_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Resveratrol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227856
MCF7_CEP-33779_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0102883
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE208096_1_v_0_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.65845
MCF7_AT9283_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126539
Altretamine_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0230162
CRCGN009_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.632
PMC4219345-1471-2121-14-52-S3.xlsx-BORIS_hNP1-Gene_Symbol_CTCFL	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K33863933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03446
Phosphatidylinositol 3-kinase complex, class IB	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.577
HEPG2	DepMap CRISPR Gene Dependency	1.0	5.05044
GSE148200_4_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE129389_0_v_5_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A02799884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35253
TCEA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33279
BRD-A77292814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02186
IFRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39166
GATAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33638
KA-71-CQ35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228448
A549_Navitoclax_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215353
MCF7_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01362
cyclocytidine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20164
K562_EED226_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145418
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4b-REST_REST	Rummagene Transcription Factor Associations 2026	1.0	null
Endolysosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.783
GSE182680,GSE182683_5_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
DD-74-PJ26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.414824
IER5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34691
CRCGN008_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.72992
BRD-K12440228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15377
BRD-K38853406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24415
CRCGN016_MCF10A.WT.HP_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16887
BRD-K52532740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45225
BRD-K32988853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56355
GSE136894_1_v_3_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K56283394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13929
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	142.766
K562_Temsirolimus_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014904
A549_Mercaptopurine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0115315
PMC12500496-262_2025_4178_MOESM2_ESM.xlsx-THP1_enriched_for_control-gene_name_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
TFAP2A-35110662-HEPM-HUMAN-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
A549_ZM 447439_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171031
GSE139966_4_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K93374700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03912
BRD-K51175229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25563
SCAMP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23536
GSE115395_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K55169051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03713
CRCGN015_MCF10A_48H:C11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12811
BRD-A38359809	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29232
MCF7_Daphnetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172809
CRCGN017_MCF10A.WT.HP_24H:P17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2047
BRD-K69580972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14331
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9198
Stat5a::Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.4762
ZCCHC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14999
MCF7_Tucidinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132023
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272699
MCF7_G007-LK_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151032
A549_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0304183
A549_Disulfiram_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208592
GSE193249_0_v_1_gpx8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K60850201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97767
BRD-K81465091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7535
BRD-K01030150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29455
Esophagus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.023
MCF7_Ellagic acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189403
Intelligence (MTAG)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.739794
RBAK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02516
A549_MK-0752_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0307267
ZMYM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18829
A549_AG-14361_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0339099
BRD-A77328129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27935
BRD-K31490008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4709
BRD-K67491390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48927
BRD-K35923751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65509
GSE179002_3_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K20073772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20086
BRD-K79494396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59674
BRD-K72681425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62777
GSE253579_1_v_0_sectm1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ETC-206_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0102736
BRD-K64763803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53326
AR-35650195-DSRCT-HUMAN-MESENCHYMAL-SARCOMA	ChEA Transcription Factor Targets 2022	1.0	null
STMN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24772
GSE208254_3_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K88504000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21834
GSE199921_1_v_0_romidepsin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9314667-Table_1.xlsx-Regulons-ELF1_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K67284043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28163
NCIH526	DepMap CRISPR Gene Dependency	1.0	3.00857
MF-81-RJ18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239214
A549_PHA-680632_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0107508
HB-79-CT92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230393
MCF7_Obatoclax Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174741
GSE201270,GSE201272_5_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K47471281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60158
Heart conduction disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.172
L363	DepMap CRISPR Gene Dependency	1.0	3.52934
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	1.0	2.06744
GSE119603_1_v_0_oxaliplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Azacitidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0228976
UBA52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15604
BRD-K70537701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45959
A549_Regorafenib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0262347
BRD-K40145790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04724
MOLM14	DepMap CRISPR Gene Dependency	1.0	2.07043
BRD-K86373784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46748
PMC10591418-12711_2023_849_MOESM11_ESM.xls-AA_E14_vs_LS_E14-gene_name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K63401195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01189
Viral meningitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
PHOX2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.403
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	121.245
BRD-K37595074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28138
GSE157296,GSE157298_4_v_3_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
THAP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11242
Longissimus lumborum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.854
BRD-K15300571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02561
SHP77	DepMap CRISPR Gene Dependency	1.0	3.15881
GSE146074_1_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE249544,GSE249637_6_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K56895780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00508
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Ofloxacin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0234645
MCF7_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131269
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.0913
KIAA1958	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10464
GSE197571_2_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165548_2_v_13_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
COV504	DepMap CRISPR Gene Dependency	1.0	4.8714
BRD-K41310621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02068
GSE125862_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13005
GSE226584,GSE226589_3_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228106_0_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100369_PCx_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.99877
GSE182680,GSE182683_5_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K75900642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09816
BRD-K23434564	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20268
BRD-K23062575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70929
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3478
TGBC1TKB	DepMap CRISPR Gene Dependency	1.0	2.00838
GSE198982,GSE198986_1_v_2_daunorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0248021
GSE157904_3_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
U118MG	DepMap CRISPR Gene Dependency	1.0	2.28362
A549_Celecoxib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156398
ZBTB7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13069
A549_S-Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141297
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23877
KIF26A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1466
BRD-K19691332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00993
AD-51-FB60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220241
GSE206226_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Atrial fibrillation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.172
ADRA2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06442
CRCGN015_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.52203
WDR26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25846
ZBTB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33992
MCF7_ABT-737_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013796
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.32919
4951_MED28_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.55157
A549_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0247177
AE-42-HT01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275618
BRD-A31916785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35358
BRD-K63209730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17538
697	DepMap CRISPR Gene Dependency	1.0	2.32826
A549_BRD4770_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193587
A549_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0267762
MCF7_Toremifene Citrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178714
MRPS9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08209
VDR-33458620-PRIMARYEPITHELIAL-HUMAN-PROSTATE	ChEA Transcription Factor Targets 2022	1.0	null
A549_CYC116_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127298
PMC9170821-JCMM-26-3183-s001.xlsx-Macro_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287741
GSE182680,GSE182683_10_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K77824583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58089
AMO1	DepMap CRISPR Gene Dependency	1.0	6.14718
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.187
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267434
Membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K68949590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.2661
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE197571_3_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120756_2_v_9_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
COPI-coated vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.05
HOXD9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5772
GSE235945_1_v_0_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_UNC1999_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179318
BRD-K63487554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82373
IA-80-OW42_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.38882
GSE198165,GSE198166_8_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH82	DepMap CRISPR Gene Dependency	1.0	3.71591
GSE168798_0_v_1_isg15_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Tozasertib_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144775
GSE173911,GSE173917_0_v_1_morc3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF_Q1_vs_Q4-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152511
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125442
BRD-K64823749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0688
GSE244072_10_v_9_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE139540_0_v_1_menadione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K80888628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24525
A549_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0278146
BRD-A37056613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68526
GSE213153_1_v_0_ulixertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K39087168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64193
FF-86-NH56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.526163
GSE161295_4_v_3_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176844
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF-_SURVIVAL-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN010_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9182
BRD-K01512588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00626
MCF7_PD173074_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156735
BRD-K77894681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30148
BRD-K19573822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41314
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8821
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.404155
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6062
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.37429
A549_AG-14361_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210801
A549_Ofloxacin_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195851
STK24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29258
A549_Raltitrexed_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0290964
8222_SNRNP70_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.71089
Zbtb2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.9902
PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Nearest_Ensembl_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE203308_6_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Meprednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0203157
A549_Divalproex Sodium_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155219
BRD-K60069390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83199
MCF7_S-Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170335
GSE167474_1_v_0_naa40_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.332292
S0-EE-XMXE_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251194
GSE218060_7_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ABI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49725
ATG9A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09798
HFL-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.568
GSE135030_8_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K11477112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10744
GSE182680,GSE182683_10_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_9_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
regulation of Golgi organization	GO Biological Process Annotations 2025	1.0	null
BRD-K18149487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09117
Semitendinosus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.548
GSE182680,GSE182683_5_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_PHA-680632_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01582
K562_JNJ-7706621_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014159
Uterine cervix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.082
A549_Divalproex Sodium_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155625
K562_Vandetanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150526
EW22	DepMap CRISPR Gene Dependency	1.0	3.613
BRD-K82175530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49095
A549_Flavopiridol HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151282
POLE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13327
GSE181517_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126345_2_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Alisertib_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013471
GSE130676_0_v_1_suds3_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_2-Methoxyestradiol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127083
BRD-K87418665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19922
A549_Crizotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157977
Vesicle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.835
BRD-K96284156	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69455
GSE241701_4_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185872_0_v_3_methotrexate_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Ofloxacin_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.012069
A549_Aurora A Inhibitor I_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0278014
Golgi membrane	GO Cellular Component Annotations 2023	1.0	null
ES5	DepMap CRISPR Gene Dependency	1.0	2.85476
2526_EIF1AD_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03146
BRD-K40143134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03962
BRD-K41307363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73156
GSE161295_0_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201309_1_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE180951_2_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210383_0_v_1_trim71_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K81801123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16766
Zfp809	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.0486
K562_WP1066_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018819
MCF7_Aminoglutethimide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163293
HC-18-NB46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.331757
BRD-K23617623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13358
BRD-K61366105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33625
A549_MLN8054_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013694
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
GSE193258,GSE193259_2_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MG63	DepMap CRISPR Gene Dependency	1.0	2.01956
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.859
ZNF558	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	143.8
A549_IOX2_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0263124
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	83.4521
CRCGN014_HEPG2_3H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3383
MCF7_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144185
A549_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0227453
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K65836113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7585
BRD-A14842104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61354
ESR1-26153859-T47D-HUMAN-BREAST-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K16717067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28059
GSE77108_3_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K95485901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55864
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_MLN8054_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144166
MCF7_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0121851
GSE233679_5_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
MEIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.5588
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.01406
BRD-K64553072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54224
GSE49929,GSE49931_1_v_0_irf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Balsalazide (sodium hydrate)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.01033
ZBTB39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03486
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.9038
BTG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00323
PD-128907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71735
MCF7_Ofloxacin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144968
BRD-K15322427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01146
BRD-K50815029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14811
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7594
GSE203308_4_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139469
MYLA	DepMap CRISPR Gene Dependency	1.0	5.15351
BRD-K56987307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06118
BRD-K94881465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22852
BRD-K78647367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96421
FOXE1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	78.6505
BRD-K01225247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53067
A549_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158599
BRD-K71537757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23519
FE-64-KC49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.325405
BRD-K72687327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3243
GSE200687,GSE200688_1_v_0_sox15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K83818372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44018
HC-38-KI38_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208503
GSE242199_6_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K44292107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04452
GSE77108_8_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.082
YF-47-HO48_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232133
A549_WHI-P154_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146635
BRD-K87412446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05408
HUH6_LIVER	CCLE Cell Line Proteomics	1.0	2.35693
A549_Lomustine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195235
D425	DepMap CRISPR Gene Dependency	1.0	2.27097
BB-77-QQ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288485
PRR11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26193
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5028
MCF7_Fulvestrant_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00772876
C8166	DepMap CRISPR Gene Dependency	1.0	5.48555
CRCGN012_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7475
WA-03-IF37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247013
JIMT1	DepMap CRISPR Gene Dependency	1.0	4.00122
BRD-K01691949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05315
AC-83-LN99_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270145
UTP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16991
K562_MC1568_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188427
SF-268 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.345
BRD-K53896147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0092
VEZT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28706
A549_BMS-911543_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152353
BRD-K70941976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65168
GSE223008_6_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE134191_3_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_AG-490_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0238194
GSE242199_6_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Familial Atrial Fibrillation	DisGeNET Gene-Phenotype Associations	1.0	null
MCF7_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135755
MCF7_Lomustine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019191
BRD-K61271364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54243
BRD-K83115645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04933
GSE242199_2_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K89805365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20689
TBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35246
BRD-A04975445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59415
BRD-K16826019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1108
PMC7064337-elife-51373-supp1.xlsx-MTF2_targets_shCTR-List_of_2011_genes_marked_by_MTF2_ChIPseq_in_control_conditions_shCTR_MTF2	Rummagene Transcription Factor Associations 2026	1.0	null
Cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GARP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.896
BRD-K40220562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61807
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER	ChEA Transcription Factor Targets 2022	1.0	null
A549_XAV-939_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199173
PMC4269325-NIHMS634665-supplement-supp_table4.xls-H3K27me3_TRIM37_KD-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K71496240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96296
BRD-K83244979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21709
BRD-K32071534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00253
BRD-K23299829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77212
A549_Toremifene Citrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185442
BRD-K44548010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06364
ZNF630	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00133
GSE178292_0_v_3_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K58336011	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41595
A549_MK-5108_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181647
BRD-K50604515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31919
ZNF491	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23307
K562_Barasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133549
CRCGN011_HEPG2_24H:A10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26447
GSE226114,GSE226116_2_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_AR-42_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127786
BRD-K72278003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.57577
A549_NVP-BSK805 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176877
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.497701
STAT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2775
A549_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195353
MCF7_Nilotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191256
CDX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.3824
A549_EED226_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.023975
BRD-K98889734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02462
A549_Tazemetostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206709
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.526418
A549_Aurora A Inhibitor I_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123125
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.411208
BRD-K27111500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46842
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147665
QB-99-OU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220793
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.172
ZNF341	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0076
A549_Selisistat_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154156
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.57469
GSE161295_0_v_5_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157282_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LD-69-ZV56_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303736
BRD-K92349794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09172
COPI vesicle coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.053
BRD-K71007902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59978
DDX24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31433
BRD-K70254692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44661
A549_M344_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140874
NPIPB13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81265
BRD-K36531580	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18146
Neuroendocrine tumor cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.848
A549_TG101209_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165946
K562_Abexinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141081
A549_AC480_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145256
SEPTIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02965
BRD-K98223571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17284
GSE249544,GSE249637_9_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K13526564	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05669
ADD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20549
BRD-K73775927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.471
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207753
Hand1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.5273
BRD-K81939454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56213
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.866744
BRD-K07565511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.36791
BRD-K34761198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19571
BRD-K70721203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37955
GSE206516,GSE206518_3_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SCAR complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.782
GSE213588_9_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Quercetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136006
MCF7_Vandetanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0231577
GSE248858_5_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GATA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98624
Mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.082
GSE190384,GSE190386_3_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Amisulpride_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160497
BRD-K72439355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04317
BRD-K72435943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22489
PMC9170821-JCMM-26-3183-s001.xlsx-Neu_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
496100529_HIP_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.6569
PMC7455079-jciinsight-5-140380-s227.xlsx-Supp_Table_9-Supplemental_Table_9_Limma_DE_Analysis_of_HC_AA_to_EA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_JNJ-26854165_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162906
BRD-K76558091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33522
BRD-K03067757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19201
GSE115395_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K63573625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09719
A549_Momelotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174781
BRD-K36134264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30179
GSE121043_0_v_1_aldh1a1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Golgi membrane	GO Cellular Component Annotations 2025	1.0	null
K562_Celecoxib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159314
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	126.317
NCIH1869	DepMap CRISPR Gene Dependency	1.0	6.31387
BRD-A07944983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33245
GSE195743_3_v_2_lhx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K73637411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15677
BRD-K35462157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16573
GSE134375_0_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K56708236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86085
BRD-K81120201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55025
GSE155031_5_v_1_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K73110675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06938
GSE130246_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K28140275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29676
MCF7_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181007
A549_Tozasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224671
BRD-K71139459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47439
GSE228413_4_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE134375_6_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Epothilone A_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181022
CCDC153	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49821
BRD-K87853964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04409
GSE217071_1_v_2_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMZ1	DepMap CRISPR Gene Dependency	1.0	4.5437
A549_ENMD-2076_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0218065
GSE210770_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5819186-13040_2018_163_MOESM3_ESM.xlsx-Lung-TCF21_TCF21	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10800016-table_s3_20230913_ddad186.xlsx-DUX4-aff_II-Unnamed_1_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Linifanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0229611
K562_PJ34_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198691
BRD-K65796649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4473
PMC9170821-JCMM-26-3183-s001.xlsx-Endo_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K07768565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58586
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K06203116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4078
H2AZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0754
GSE226091,GSE226092_0_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE231799_3_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K67531128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03798
BRD-K16062794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68871
GSE101527_0_v_1_smad4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210667_1_v_0_rfx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
BRD-K96623405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38024
Brain - Spinal cord (cervical c-1)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.5756
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265618
PMC10120406-JEM_20220962_DataS2.xlsx-Elf1_target-Data_S2_List_of_Elf1-target_genes_2_d_after_LPS_pIpC_stimulation_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K82517280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0231
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201713
GSE79291_1_v_2_streptozotocin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114992,GSE114993_1_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE164463_0_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Toremifene Citrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185519
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZMYND19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99101
Zic1::Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.9883
BRD-K35808731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21428
MCF7_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161251
BRD-K57045425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81497
BRD-K99546030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09971
A549_Rucaparib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138522
MCF7_Ellagic acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018966
BRD-K60701773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04386
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.718196
GSE152050,GSE152052_1_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-1912_ChIP-Seq_H3K9me1_2_demethylation_and_ChIP-Seq_AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
NAMALWA	DepMap CRISPR Gene Dependency	1.0	2.40856
496100635_HIP_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.21563
GSE144347_1_v_0_crnkl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Enzastaurin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144802
A549_Danusertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110174
K562_Linifanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153674
BRD-A41916216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00263
GSE130217_0_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HC-01-FD24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.433171
RNASEH2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33016
A549_Pracinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0104405
BMF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20756
PMC6080909-JEM_20171312_TableS1.xlsx-Each_THP1_Pulldown_Expt_Targets-Unnamed_1_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K22189231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44912
GSE192663_3_v_2_acly_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Exocyst	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.148
TMEM30A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39152
GSE173232_1_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K71604365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66023
KMRC1_KIDNEY	CCLE Cell Line Proteomics	1.0	3.23989
CA-68-KG29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.69724
GSE121866_1_v_3_six4_human	RummaGEO Gene Perturbation Signatures	1.0	null
HNF1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.9261
BRD-K95192796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21928
GSE225869_3_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.59239
GSE244233_1_v_0_quercetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K49215099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85353
BRD-K82538319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41214
8505C_THYROID	CCLE Cell Line Proteomics	1.0	3.01133
A549_Givinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137922
betamethasone-valerate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05458
GSE240027,GSE240030_1_v_4_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Glesatinib(MGCD265)_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215518
GSE146982_0_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DD-74-PJ26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300684
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.16113
A549_AR-42_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134918
A549_Roscovitine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0121918
Stat6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.2403
A549_Gandotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122618
BRD-K04725393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14181
BRD-K64953645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50439
Brain - Amygdala	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.01357
A549_Roxadustat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157567
PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242199_9_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016452
GSE248858_6_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Divalproex Sodium_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017916
MCF7_Regorafenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142745
A549_Vandetanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175716
BRD-K95500860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39056
K562_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017752
BRD-K46942548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31893
MCF7_AICAR_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165432
PPM1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37125
BRD-K80679698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31559
A549_Streptozotocin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177325
BRD-K47821225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29599
GSE135030_8_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE171837_3_v_1_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K13265046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22233
BRD-K93195567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57557
A549_Roscovitine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166665
8-M-PDOT	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54066
SLC25A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41493
PMC6187090-mmc1.xlsx-TP53_positive-Symbol_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
Epididymis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.082
A549_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138725
PMC10534007-Table_2.xlsx-S6_unique_down_MSC_B-914_elements_included_exclusively_in_BFTC905_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172642
Uterus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.76266
ZD-74-FC07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235001
A549_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0321643
GSE91015_0_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE249098_3_v_2_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FAM32A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06535
BRD-K40732885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72819
K562_Clevudine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152808
A549_Tozasertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167927
Tezacaftor	DeepCoverMOA Drug Mechanisms of Action	1.0	0.22
A549_Prednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146762
GSE135030_8_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146982_0_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.329701
MCF7_ENMD-2076 L-Tartaric acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129467
NR2C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2542
Thorax	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.442
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_R_species_not_found_in_common_genes_of_LF_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
RASGRP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05599
Cytosol	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K83459401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27358
BRD-K42508877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88339
BRD-K63809385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66329
BRD-K18128277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23887
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OSGIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78331
BRD-K11987248	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09557
GSE112761,GSE112767_4_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SC-72-YW56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269909
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.1222
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRIPT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27095
A549_Bosutinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0242691
ZKSCAN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1438
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204999
WF-85-JN16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270105
BCCIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21132
PMC8384902-mmc5.xlsx-H2107_PROX1_ChIP-Symbol_PROX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K86232678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48607
PMC3435504-msb201237-s2.xls-Supp_Table_4a-REST_REST	Rummagene Transcription Factor Associations 2026	1.0	null
DBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48398
KMS34	DepMap CRISPR Gene Dependency	1.0	2.87553
GSE218907_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PAQR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31784
GSE190384,GSE190386_1_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Crizotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163871
ONECUT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.1384
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.404228
MOLM13	DepMap CRISPR Gene Dependency	1.0	4.13628
GSE190534,GSE190536_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE81193_3_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Curcumin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125222
LO68	DepMap CRISPR Gene Dependency	1.0	2.04433
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.3554
BRD-K50961262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59521
A549_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209003
A549_AZD1480_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0219245
BRD-A12166214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16466
BRD-A08820802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27423
BRD-K39962926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08279
A549_Tanespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128141
A549_Abexinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160394
A549_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178416
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.4405
A549_Crizotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0274081
BMI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10556
GSE167474_2_v_0_naa40_human	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal trophoblast layer morphology	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K69158240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4805
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.592727
K562_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016696
BRD-K32402344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4471
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Maraviroc_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0236429
GSE153137,GSE153140_2_v_0_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0222486
A549_Barasertib_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152091
A549_MK-5108_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0278544
MCF7_FLLL32_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0288045
PMC8088646-13148_2021_1081_MOESM1_ESM.xlsx-ST12-Unnamed_1_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
A549_SRT2104_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208818
GSE229973_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K38861721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04324
Doxycycline (monohydrate)_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0123058
BRD-K73582217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04776
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.89
URI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01032
HT	DepMap CRISPR Gene Dependency	1.0	2.94455
BRD-K52319351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18924
HUH6	DepMap CRISPR Gene Dependency	1.0	2.24562
GSE235605,GSE235701_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HB1119	DepMap CRISPR Gene Dependency	1.0	2.07292
GSE201877_1_v_0_yap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K74506898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32346
GSE102467_3_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE77108_6_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154966
A549_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216452
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.469739
MCF7_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147059
BRD-K75041866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54715
ERCC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0783
DUX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3455
Organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.543556
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27213
Brain - Substantia nigra	GTEx Tissue Gene Expression Profiles 2023	1.0	2.69041
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_Jurkat_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
JHH5_LIVER	CCLE Cell Line Proteomics	1.0	2.17831
SHISA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07898
MCF7_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146877
BRD-A39660642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31076
BRD-K51237617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0887
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.38859
BRD-K32759631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12633
GSE122215,GSE122217_5_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Fasudil_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190216
BRD-K34602185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04823
AB-04-NN16_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238809
A549_Iniparib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194842
BRD-K86208187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2483
3436_RACK1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.45228
Nkx2-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.9509
MCF7_CUDC-101_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182908
A549_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0283935
A549_PJ34_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143688
NCIH211	DepMap CRISPR Gene Dependency	1.0	4.09642
BRD-K55841827	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90468
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3964
IGR1	DepMap CRISPR Gene Dependency	1.0	2.0047
A549_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178843
TNFAIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52304
A549_MC1568_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0254773
BRD-K13941052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06878
BRD-K86237035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03874
GSE93309_2_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Persistent Atrial Fibrillation	DisGeNET Gene-Phenotype Associations	1.0	null
FXYD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07844
GSE135030_11_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.728628
GSE84148,GSE96938_0_v_2_nrros_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_UNC0631_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0309238
BRD-K16267084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09142
BRD-K61078510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03834
BRD-K63364685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15274
ZNF692	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06125
GSE171837_0_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_A-366_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157816
KYSE180_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	4.75636
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.369613
MCF7_Hesperadin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128159
SNX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19661
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.9318
K562_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159958
Cellular anatomical entity	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
FBXO38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57922
UBR5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93113
BRD-K74927219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45599
CRCGN017_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.79868
GSE242199_9_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K10925833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05405
MCF7_Entacapone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0240156
A549_Avagacestat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199769
CDX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1965
KA-75-LP02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.422868
Esophageal epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.653
GSE244710_1_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
WWC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15975
BRD-K12841150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18633
MIA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84117
GSE158834_11_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE81193_0_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K35963610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38448
PMC9170821-JCMM-26-3183-s001.xlsx-Endo_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9942321-12916_2023_2766_MOESM1_ESM.xlsx-S9-Supplementary_Table_9_DEGs_distributed_per_SOM_profile_in_all_IS_etiologies_based_on_Euclidean_distance_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K71919612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23742
MCF7_IOX2_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0218376
BRD-K02624294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01177
K562_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155756
A549_Lomustine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145835
K562_PCI-34051_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187863
GSE227698_5_v_3_g0s2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K66831269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34113
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.552134
GSE201309_4_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K81400584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22639
BRD-K22449045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52406
regulation of Golgi organization	GO Biological Process Annotations 2023	1.0	null
PHOX2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.7612
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.02886
GSE236454,GSE236456_0_v_1_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3218
GSE125014_6_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K12260399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19757
GSE169205_0_v_8_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IDRA-21	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.22916
BRD-K99856384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09761
BRD-K32205799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51868
GSE159678_6_v_7_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	1.0	null
General cognitive ability	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.21549
Endomembrane system	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE155031_6_v_2_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192971
BRD-K77407030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32327
K562_Tanespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150735
GSE171837_0_v_3_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Capecitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149807
CRCGN011_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0362
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.989912
WM88	DepMap CRISPR Gene Dependency	1.0	2.89932
GSE148200_1_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K74176533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78157
GSE213588_9_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Glesatinib(MGCD265)_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148067
PMC10202654-mmc3.xlsx-Sarcoma_markers-LIPO_HMGA2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K73680186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2074
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250827
PMC7203476-Table_2.XLSX-MI_treat_vs_control-Unnamed_0_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
P4E6	DepMap CRISPR Gene Dependency	1.0	2.97446
BRD-A16827030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.361
BRD-K81758631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10785
Golgi membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
MFE296_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	2.58831
BRD-K57323824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17303
CRCGN015_HEPG2_48H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.77721
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.465218
MCF7_Enzastaurin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171988
BRD-K84266230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00506
BRD-K71194915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13027
GSE190384,GSE190386_0_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K28596340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74237
CRCGN016_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.91933
K562_Tranylcypromine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196294
A549_Panobinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175609
BRD-K22045035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65593
GSE228106_0_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Roxadustat_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123552
BRD-K14394756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21908
BRD-K50146114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59702
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.06924
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5928
A549_Ofloxacin_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129005
YH13	DepMap CRISPR Gene Dependency	1.0	5.1897
BRD-K85977570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40186
GSE201110_0_v_1_sirt4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A98888138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77149
BRD-K92356128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19236
BRD-K92210988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21576
ASPC1_PANCREAS	CCLE Cell Line Proteomics	1.0	3.73134
BRD-K63960902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67025
BRD-K41504921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84262
BRD-K88292241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26846
CRCGN014_HEPG2_24H:H13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04317
A549_Roxadustat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0289324
K562_INO-1001_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166815
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2974
BRD-K87092114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80736
BRD-K32170456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30167
GSE196540,GSE196542_2_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BC3C	DepMap CRISPR Gene Dependency	1.0	2.00428
MCF7_M344_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126976
PMC6902611-40104_2019_400_MOESM2_ESM.ods-FA-SNA-Total_of_1_054_out_of_1_627_proteins_were_considered_for_analyses_65_SNAI1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K94273044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12037
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.454948
K562_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150903
TMEM18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07789
CC-49-CQ25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.296278
FOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.4299
BRD-K89537738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87756
BRD-K24523560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61538
TAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24909
BRD-K93503664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48683
GSE157592_1_v_0_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.38583
TRAF3IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22967
DA-20-VR86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278081
A549_SRT2104_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0303014
GSE213632_3_v_6_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.4536
T98G	DepMap CRISPR Gene Dependency	1.0	2.07171
BRD-K61139423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21288
BRD-K54769228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54778
S0-EE-WNJ9_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.352769
COPI-coated vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.009
GSE143955_1_v_0_ripk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K29246335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3968
BRD-K79712504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43679
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF_D1_vs_D10-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K97711917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49188
GSE217552_3_v_5_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE139540_4_v_1_menadione_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_S-Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195407
MERO95	DepMap CRISPR Gene Dependency	1.0	4.16896
Household income (MTAG)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.20458
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_ITSA-1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155593
HMGB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18362
FNBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0167
BRD-K62312047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64653
A549_Cediranib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179931
MCF7_Tanespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00911971
BRD-K97106314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.56323
BRD-K02833343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06434
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6847
CRCGN012_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01636
GSE210885_0_v_4_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_BMS-265246_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139426
BRD-K63665694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22995
BRD-K28601178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07325
PMC6713698-109_2019_1809_MOESM2_ESM.xlsx-AR-PCOS-Gene_List_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K33177501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30603
A549_Motesanib Diphosphate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014335
GSE147959,GSE147960_5_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SF295_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	3.29343
SUM-159PT cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.72
BRD-K42529194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34438
GSE150055_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Zic3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.6287
BRD-K08715918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11491
Aspirin_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0135366
Tonsil	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.082
MCF7_Meprednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184399
K562_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01309
MCF7_Motesanib Diphosphate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208723
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5946
HB-24-GP45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246955
MCF7_Clevudine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183739
GSE171269_1_v_3_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.1262
GSE200352_10_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EDEM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17627
Nr5a1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.4098
Gli1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.68
C3orf18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07836
GSE125007,GSE125008_10_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185237
BRD-K08233096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09199
STAT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2065
MCF7_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0256415
BRD-K53893978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41963
A549_Aurora A Inhibitor I_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236156
A549_Danusertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162009
A549_Glesatinib(MGCD265)_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01411
BRD-K25408656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08622
SUDHL4	DepMap CRISPR Gene Dependency	1.0	4.9468
BRD-K53768630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16119
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.483169
A549_Belinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189313
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.5806
ADCK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71338
PMC10123531-NIHMS1874945-supplement-Table_S7.xlsx-SOX17_BCAT_4TCFKO_peaks-Gene_Name_SOX17	Rummagene Transcription Factor Associations 2026	1.0	null
EB-07-JB09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.399804
ZNF618	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20075
BRD-K54453373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23475
Spleen	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.45202
VA-48-RJ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.728679
GNG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61978
GSE182680,GSE182683_5_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE236437_2_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE198165,GSE198166_0_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Andarine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184508
FD-62-ZB67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231172
BRD-A70931301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26664
PMC7291745-12967_2020_2407_MOESM2_ESM.xlsx-Table_S1D_CCF_pairs-locus_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K75853175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20234
CRCGN014_HEPG2_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01382
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6141
GSE138789_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OCILY3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	5.44211
A549_Rucaparib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136005
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.09085
GSE182680,GSE182683_5_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE229973_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE139966_1_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Hesperadin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0109308
BRD-K35001076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21043
A549_Tie2 kinase inhibitor_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202402
Poliomyelitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.147
BON-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.353
A549_Quisinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0121411
GSE207301,GSE207303_1_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K29253960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19634
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238556
Pulse pressure	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.25229
PMC10928104-41419_2024_6576_MOESM4_ESM.xlsx-S14-FOXM1_targets_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148263_6_v_0_trim3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Obatoclax Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195393
A549_Divalproex Sodium_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151166
BRD-K08939002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.99764
A549_GSK-LSD1 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0242166
A549_Decitabine_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.020135
BRD-K62418398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15701
A549_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0308195
GSE213588_10_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K75844518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05056
UF-14-LK87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.308468
BRD-K80779045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6183
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Golgi apparatus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE225684_0_v_2_tfap4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_TG101209_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218648
AD-55-WK61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208798
OUMS23	DepMap CRISPR Gene Dependency	1.0	3.79936
MCF7_SRT2104_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125348
BRD-K02630367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90123
GSE209938_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K40358491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06819
GF-92-IR00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200594
bounding membrane of organelle	GO Cellular Component Annotations 2023	1.0	null
Egg yolk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.912
GSE165122_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FTCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53993
BRD-K09721867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07812
Bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
K562_AT9283_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016867
KML1	DepMap CRISPR Gene Dependency	1.0	2.82082
BRD-K85851814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06948
A549_Flavopiridol HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141826
IRF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3904
RVH421SKINFV1	DepMap CRISPR Gene Dependency	1.0	4.34681
BRD-K14645917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5716
BRD-K05253426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59571