association	dataset	threshold value	standardized value
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.2723
GSE166783_4_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23649
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE166783_8_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:E08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06769
CRCGN012_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0322
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2627
Msgn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	41.4852
496100423_PCx_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04224
GSE150669_0_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.785155
R2TP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.228
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RNA polymerase III complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.652
IRX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90618
ROR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53265
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.659068
GATA5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.149
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.0573
CRCGN014_HEPG2_3H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6088
GSE110524_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EMX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7122
GSE149903_6_v_1_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE155852_0_v_1_apigenin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BATF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5242
FOXD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.376
NEURL1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66833
GSE102675_2_v_1_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WNK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26365
CDK17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.825
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.4239
Amelanotic melanoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.984
GSE125782_3_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.05051
FBXL18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84608
TDRD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16568
UNC50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39924
4651_LRP8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.2193
DNAJC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73808
GSE167224,GSE168147_3_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SIX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4821
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6842
GSE113329,GSE113335_3_v_4_taf6l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147959,GSE147960_5_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203876
Laropiprant	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
GSE139966_1_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_1_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7515_RPS26_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.548863
GSE158834_7_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE180641_0_v_1_zfp503_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE183994_3_v_0_scml2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.21768
GSE87144_6_v_1_rorc_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF214	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.721
GSE148252_1_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mecom	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.3704
SLC25A46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83538
GSE104022_1_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.64555
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.430376
Tbx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	55.3032
GSE198794_0_v_3_usp18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112762,GSE112767_1_v_0_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148252_7_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MB-32-LQ97_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257782
Dlx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.0683
CRCGN015_HEPG2_48H:P15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20662
PMC10913870-pr3c00632_si_001.pdf-122-ZHX1_ZHX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE208096_1_v_0_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111061_1_v_3_tofacitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.849
UHRF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.23322
E2F7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.3783
GSE174701_5_v_8_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BE-27-RQ61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.406309
chr2_189736026_G_A_b38	GTEx eQTL 2025	1.0	2.26565
GSE132313_1_v_0_fosl2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211931_2_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-98-QW77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.368028
chaperonin-containing T-complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.831
CRCGN015_MCF10A_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.4689
CRCGN015_HEPG2_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.17437
TMEM87A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54673
GSE158834_11_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.586405
DD-43-WW40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22252
RIMS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36719
GSE145311_1_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
3054_FECH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.584204
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1485
EVX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16297
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Tonsil	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.501
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	75.1638
Hoxd13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.0489
MAN2A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89868
FOXF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1061
CRCGN009_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.04515
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Neuroblastoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE206226_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LZTS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9566
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0911
496100628_FWM_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.45125
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.57827
NFATC3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0661
MOAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39451
GSE129725_1_v_5_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FANCG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58305
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252993
PPP1R26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30015
GSE145628,GSE145629_1_v_0_myrf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Tentacle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.055
CB-87-RB49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237236
GSE92589_0_v_1_sirolimus_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE108326_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE110178_4_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Nr1h3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.6722
TOPORS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70566
BATF::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6308
GSE227592_8_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE225869_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.67775
CRCGN009_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29495
CRCGN015_MCF10A_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.26345
CRCGN013_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.33482
CRCGN015_MCF10A_48H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02061
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.452948
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04551
PHC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94116
ZNF382	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.5828
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0182
DLX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2611
CRCGN015_HEPG2_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.1139
Hmx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.8586
CRCGN016_MCF10A.TP53.M_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17989
GSE196343_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Dmrt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.9073
RFX7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5797
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.38237
496100545_HIP_possible Alzheimer's disease_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.21909
GSE139239_3_v_6_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149760_0_v_5_elof1_human	RummaGEO Gene Perturbation Signatures	1.0	null
AC-44-UR36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.418121
Elf5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	46.1438
HC-63-SV27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217493
GSE206870,GSE206872_4_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RRP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32243
ZPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38051
FSBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95183
ZNF708	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.1755
GSE118765_1_v_5_rreb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Tcf21	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	67.143
DHODH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05932
GSE101537_1_v_3_neurog3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE137144_3_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NES-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE197571_2_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
S0-EE-YNU4_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.352008
chr2_189671557_A_G_b38	GTEx eQTL 2025	1.0	2.3709
LMX1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1631
CRCGN011_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.88455
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157S_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9364
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.6694
SLC12A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32761
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2025
CDKN2AIPNL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51918
GSE147943_0_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211226_1_v_0_sirpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48784
GSE185744,GSE185747_2_v_4_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_6_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE137818_3_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE209582_1_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPL18A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55627
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	98.276
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7675
MSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1183
CRCGN015_MCF10A_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.06495
7504_RPS15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.76404
GSE161864,GSE161866_4_v_3_ror2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-51-FB60_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.505244
Liver cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Hmx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.9171
MYBL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4478
NFYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0952
NKX2-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2996
Cortical microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.773
GSE237040_6_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226114,GSE226116_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SOX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5
GSE226249_5_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Rosette leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.967
DPRX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0684
GSE217541,GSE217543_0_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
DNA recombinase mediator complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.296
FOS::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.7466
Ar	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	70.2057
GSE102675_3_v_0_atf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE221356_1_v_0_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Liver cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.118
GSE165308_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE227127_1_v_0_diclofenac_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21782
OE-89-FS84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215699
CRCGN015_MCF10A_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0419
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DYNC2I2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05314
CRCGN015_HEPG2_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.3992
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.0566
CRCGN014_HEPG2_24H:A10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16572
CRCGN015_MCF10A.WT.HP_24H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.9346
SLC38A7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3514
PBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.8889
Hepatic stellate cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.541
ZNF740	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97888
Nfe2l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	46.9807
RHPN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37257
DUX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.1561
GB-73-QS80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22579
GSE144231_3_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE241036_4_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE127916_1_v_0_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
ATAD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38839
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	52.8786
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.1556
H2BC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38932
GSE172490_5_v_3_junb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CSNK1E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50465
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.472947
PODXL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22438
CRCGN015_HEPG2_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.58445
496100478_HIP_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.10619
GSE109913_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
LHX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4953
UNCX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4774
ARL8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3537
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231632
HEXD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26687
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6307
CRCGN016_MCF10A.TP53.M_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13235
GSE171177,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE73562,GSE73563_1_v_2_preb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9693
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241488
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.362829
GSE200839,GSE233826_3_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216043_7_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	111.051
GSE208254_4_v_5_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145249_1_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
DLG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7622
Arid3b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.5015
GSE206784_3_v_4_ninl_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE88819_3_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prdm14	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.2836
BCATc-In2	DeepCoverMOA Drug Mechanisms of Action	1.0	0.26
RND3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02787
TUBB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49798
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9164
GSE144838_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HMG20A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64166
PAX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68869
GSE192689_0_v_2_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.495428
CRCGN015_MCF10A_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.79872
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11618734-ac4c05127_si_004.xlsx-OPTI-PISA_automated_MTX_900ng-Unnamed_2_ZNF568	Rummagene Transcription Factor Associations 2026	1.0	null
BAIAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.301
GSE79696_0_v_1_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE240444_2_v_3_idasanutlin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Scale	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.603
SPRTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.15808
MAPRE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46468
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.0013
GSE217541,GSE217543_0_v_1_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE63048_11_v_12_morc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CPZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39658
FAM120AOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80984
GSE193993_1_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE63048_11_v_6_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JDP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.1721
ZBTB32	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4396
GSE196671_5_v_8_obox4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228413_0_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ADIPOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78922
GF-57-MY04_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249798
GSE142684_0_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Axonemal outer doublet	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.002
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.126
PRMT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66408
GSE102870_11_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
E2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.7191
Uterus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.126
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.1667
GSE147834_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95688_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AA-46-GL76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288951
Uterine endometrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.126
CRCGN008_HEPG2_24H:J03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3304
GSE213228_4_v_3_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE132369,GSE132371_3_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
CIP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30734
GSE189683_3_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PKP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46936
GSE102505_6_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE100528_1_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nobox	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.0526
Box H/ACA snoRNP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.2
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.9727
CRCGN008_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.89695
ZNF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98484
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215446
CRCGN015_MCF10A_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.21065
GSE119978,GSE180930_3_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE232564,GSE232566_0_v_2_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE200982_0_v_2_plac8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE248858_1_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE101527_0_v_1_smad4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE155800_1_v_0_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOSL2::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.1897
PITX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0226
GSE139966_4_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110178_1_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.84868
CRCGN015_HEPG2_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31145
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE116810_2_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
BOD1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65882
RAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0827
ATR-ATRIP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.745
PANK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36284
GSE161846,GSE161849_1_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
HOXC13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.255
FOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.4537
GSE165122_2_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HCC-15	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.049
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5044
GSE235066_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE253041_1_v_0_ramp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE161295_4_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ARF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72964
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268956
GSE68156_0_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.666756
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
AMMECR1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8697
GSE152637_1_v_0_imiquimod_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BHLHE23	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8097
CRCGN015_MCF10A_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.70407
GSE225869_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
sno(s)RNA-containing ribonucleoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.115
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.31684
GSE172247,GSE172250_0_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE71674,GSE71676_0_v_2_cbfa2t2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HC-01-FD24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.324396
GSE48812_11_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PHOX2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	88.3734
GSE193993_0_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Tcf12	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.9873
Lhx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.5551
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45044
RARA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	100.37
CRCGN017_MCF10A.WT.HP_24H:K22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4902
GSE150349_0_v_1_msx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE42805,GSE42811_1_v_0_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.48579
GSE233679_5_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Medulloblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.615
GSE214823,GSE214824_0_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145323,GSE145324_3_v_2_rfx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE108614,GSE108615_3_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CC-48-OM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206815
ZNF763	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91784
BRME1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57963
NFATC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9276
METTL7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88016
Nkx2-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.7111
LBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2791
DMRTC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.5313
GSE229468,GSE229471_0_v_3_znf587_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6854
Urinary bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.126
SND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65202
VB-89-RG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291558
H4C6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.70545
DF-00-BX35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247136
CRCGN015_HEPG2_48H:J17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.9451
RUNX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.1053
Nr2e3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.913
CRCGN015_MCF10A_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.90996
MB-32-LQ97_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28865
GAL3ST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38584
GSE157262,GSE157268_3_v_0_ythdc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.7981
GSE169205_3_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Prdm15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	44.5194
GSE217873_1_v_2_nusap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224969,GSE224971_0_v_7_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.0692
8651_TAF10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.765322
SGTB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65792
BACH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.771
GSE183994_1_v_0_scml2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.33973
LOX-IMVI cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.038
FOXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.2266
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.502317
GSE148066,GSE157787_0_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Placenta	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.329
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8168
Mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.126
6118_PCED1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.697893
GSE160817_0_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXD10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8347
DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0451
TLX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9961
Liver iron content	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.03979
FE-64-KC49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.989825
9909_XRCC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.549952
CRCGN015_MCF10A_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.56155
GSE108614,GSE108615_0_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CDX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.0378
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZNF766	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.3911
CRCGN016_MCF10A.WT.HP_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.87419
USP24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02449
ATP5IF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91593
Hoxa11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.9263
GSE207611,GSE207612_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.54357
GSE198165,GSE198166_0_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE234289_3_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206226_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE137177_2_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114992,GSE114993_0_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199543,GSE239447_0_v_4_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Radicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.69
GSE228106_0_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE227891_2_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Amyotrophic lateral sclerosis type 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.325
CRCGN014_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.4129
GSE147056_2_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOSL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.3344
PHF14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09595
GSE186223,GSE186224_6_v_3_hmces_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.43711
MIXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5116
GSTK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57886
GSE226316_0_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.686
NC-27-AD53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317668
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.0123
GSE93674_2_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165682_0_v_3_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:C04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.78601
PGR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.9435
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.445541
GSE214442_0_v_1_pak4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3086
PLPBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89867
Hmga1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	48.4687
GSE130383_1_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112860_5_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	78.5157
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200114
GSE202284,GSE202289_12_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186440,GSE186443_2_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DACT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94563
GSE121824,GSE121826_0_v_3_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF213	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.2183
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MIER3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23395
STX17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20375
CRCGN015_MCF10A_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.29855
KLHDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66589
GSE90710_1_v_0_med13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MTHFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89327
Adenocarcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RUNX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.9179
CRCGN017_MCF10A.WT.HP_24H:E04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.80702
GSE124410_2_v_5_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.712
GSE203158_5_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114992,GSE114993_0_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	209.495
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE134029_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TFEC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1181
GSE147240_3_v_4_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE139348,GSE139349_1_v_0_dicer1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112860_0_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE264621_1_v_6_secretin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE124304_1_v_0_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ERI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15483
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	131.627
STUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44342
CRCGN015_MCF10A_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.98442
Plagl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	45.6252
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RHOXF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1786
GSE253041_3_v_0_ramp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Floral meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.806
TTT complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.115
GSE137818_5_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203308_14_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BF-94-CQ58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235238
GSE148066,GSE157787_9_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180200,GSE180201_15_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE225869_3_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211151_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Olig2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.7833
MKI67	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72482
GSE208254_3_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LHFPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10727
PHTF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74737
ZNF184	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3795
CRCGN016_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29461
CRCGN015_MCF10A.WT.HP_24H:O22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24855
CRCGN015_MCF10A_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.6081
GSE140965_2_v_3_mybpc3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ATG16L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66705
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
HNF4G	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.768
POU3F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.2646
GSE169571_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
LA-44-KW22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213745
CRCGN008_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.38435
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.1455
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE75976_3_v_4_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF71	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.00824
CRCGN015_HEPG2_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.11768
NANP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0558
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CDX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.8637
GSE87862_0_v_1_mov10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9243
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	70.5289
GSE159148_0_v_1_sdc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2303
GSE130246_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.41
CRCGN016_MCF10A.WT.HP_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04078
GSE217071_3_v_2_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171401_1_v_0_adnp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE168797_1_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7915
Outer dynein arm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.106
CRCGN012_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.32884
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9118
HK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26619
GSE138019_1_v_5_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7452
SD-82-GT69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.35668
CRCGN015_HEPG2_48H:B21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29316
MTHFD1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69258
GSE215086_8_v_6_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF341	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9533
GSE199874_4_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1202
U5 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.279
GSE147210_2_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_5_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Root quiescent center	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.989
GSE213715_0_v_1_iqgap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.84725
GSE224969,GSE224971_0_v_5_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Amylin receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.61
CRCGN015_HEPG2_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.68448
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GADD45G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57051
Transcription factor TFIIA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.902
GSE149903_6_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TRIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17568
GSE184087_4_v_3_tert_human	RummaGEO Gene Perturbation Signatures	1.0	null
SOX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.87
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE143662_3_v_1_dcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.132
ABHD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39326
CRCGN015_HEPG2_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.39702
Nanog	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.5355
CRCGN015_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.41457
RPAP3/R2TP/prefoldin-like complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
2983_FAU_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.519108
GSE190555,GSE190557_2_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.4035
GSE185744,GSE185747_2_v_3_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DC-63-KC77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201076
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.3766
GSE196962_4_v_3_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151782_1_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CE-23-HP88_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204241
HESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5857
CRCGN010_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07768
CRCGN015_MCF10A_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.55453
GSE149264,GSE149267_2_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119603_1_v_0_oxaliplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:H23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21807
GALNT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59607
GSE210885_0_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
protein stabilization	GO Biological Process Annotations 2025	1.0	null
GSE140651,GSE140653_3_v_7_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190316,GSE190324_0_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_11_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:J13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15415
HMBOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7855
CRCGN016_MCF10A.TP53.M_24H:O22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17051
SLC30A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94244
FOXN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89058
GSE179036_1_v_0_trim24_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_6_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ASAP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.591
GSE211177,GSE211178_0_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.1131
ATPAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60504
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.931
GSE152937_12_v_1_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-50-HU68_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236778
Nkx3-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.3326
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	96.4112
GSE224969,GSE224971_0_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JUN::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1795
TSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04603
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8956
GSE229671,GSE229673_2_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DMRTA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5035
Dlx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.9837
Molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.08
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.6119
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.61558
CRCGN017_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.06695
GSE77108_0_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HLF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.2267
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ADA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17162
CRCGN017_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4743
RPAP3/R2TP/prefoldin-like complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.19
NFYA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.064
GSE224547_1_v_0_cftr_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE121319_1_v_0_gprc5a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11772884-41421_2024_747_MOESM6_ESM.xlsx-8_DEGs_RUNX1-OE_vs_control-Gene_Symbol_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
DCK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65705
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Zfp335	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.0952
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	101.394
GSE102467_3_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2919
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.1566
GSE102269_1_v_2_clpp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CREB3L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8039
chr2_189661498_C_T_b38	GTEx eQTL 2025	1.0	1.44008
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.531906
496100461_PCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.85009
GSE104022_1_v_7_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6474
CRCGN015_HEPG2_48H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22404
AB-70-GR31_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272532
CRCGN015_MCF10A_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29588
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.5337
chr2_189745061_C_T_b38	GTEx eQTL 2025	1.0	1.49495
GSE210101,GSE210114_11_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
SLC37A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82539
SIX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.8791
SOX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5901
GSE158834_11_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.1852
Yy1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.6771
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.14557
GSE100863,GSE100864_3_v_0_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF486	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05111
Mouth	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.1
GSE149264,GSE149267_4_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE139966_1_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Box H/ACA RNP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.006
HOXC10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.1717
CRCGN013_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7511
CRCGN012_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6522
CRCGN015_MCF10A_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30903
PTGIS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84222
GPR160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82315
ONECUT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	91.0183
GSE206270_1_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE98898_7_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23614
GSE202434,GSE202438_4_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE153341_2_v_3_atf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RBPJ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7469
Nrf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	45.5783
CRCGN015_MCF10A.WT.HP_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8798
GSE221327_10_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140607_0_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152055_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8567
GSE158834_11_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Axonemal dynein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.368
GSE184087_4_v_5_tert_human	RummaGEO Gene Perturbation Signatures	1.0	null
Inner dynein arm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.166
GSE180200,GSE180201_5_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Infratentorial cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.1494
GSE154577_2_v_5_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
THAP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2762
PF-39-DY68_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200878
GSE246660_1_v_0_glycerol_human	RummaGEO Drug Perturbation Signatures	1.0	null
2990_FBRS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.529428
SLU7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10788
GSE158834_7_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NR1D1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4827
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.1696
CRCGN015_HEPG2_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.85785
GSE147943_5_v_1_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE71385_1_v_0_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171837_3_v_1_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EHMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92291
GSE220520_3_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MB-32-LQ97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286826
CRCGN010_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3877
ATF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3875
GSE184210_0_v_1_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.53489
496100470_HIP_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.16882
GSE136622_0_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE68155_3_v_2_gpr3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOSL2::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.6162
RFX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2574
MCF7_AZ 960_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111024
GSE203308_14_v_5_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BHLHE41	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.735
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.9178
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207054
HOXC11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3812
Gli2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.7327
U4 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.57
GSE180982_1_v_0_mlst8_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100473_TCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.08482
GSE198165,GSE198166_0_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8917
6845_PSMA5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.63718
ESRRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5235
GSE131377_1_v_3_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178255_5_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.411637
NKX2-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3191
GSE94814_2_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POU3F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.9189
Medulloblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
CRCGN015_HEPG2_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.18606
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.189
GSE112762,GSE112767_2_v_0_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MANEA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62891
CRCGN008_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4878
LDB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52993
RORB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6432
ASF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24605
GSE63048_11_v_5_morc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CA-42-YI34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214732
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.883
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.00432
Breast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.126
CARNS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79548
GSE130401_6_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
IC-05-AW29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274176
Mafg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	59.9733
GSE114992,GSE114993_8_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318621
NR2C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.2463
CRCGN015_MCF10A_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.39824
GSE145311_0_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:E01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09676
GSE245270_1_v_4_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IRF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.3136
KD-31-TU05_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214644
POU3F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.0564
Parathyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.501
CCDC9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95649
VAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8816
Swr1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.706
GSE238116_3_v_0_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.126
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3476
LY334370	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
GSE211931_1_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.73142
PDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9277
GSE112762,GSE112767_1_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.7386
GSE162739_7_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217071_3_v_0_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.417209
OB-06-WW76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.299777
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.54109
SA-40-VR29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266442
GSE242083,GSE242098_2_v_0_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226249_5_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H2AC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18213
WSCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88651
GSE178255_2_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Childhood medulloblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.862
FBLL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5269
GFI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.9103
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148252_1_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POGLUT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80027
GSE130246_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178255_5_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12245
Insect tracheal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.072
ALG6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46363
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.126
MYT1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89743
ARGFX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1845
GSE125014_6_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.60447
GSE129186,GSE129223_0_v_1_aicda_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Chaperone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.973
ZBTB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26647
GSE213228_4_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.126
PEER cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.293
POU2F1::SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	92.6347
CRCGN015_HEPG2_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.44909
CRCGN008_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7903
Gfi1b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.7712
GSE101537_4_v_2_neurog3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149880_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Stat5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.5308
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Quinidine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
PABPC1L2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88186
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZSCAN29	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3714
HOXD9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3582
CRCGN015_MCF10A_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4155
Rectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.501
NDFIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8045
Dlx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.6283
APEX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68043
FOSL1::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.684
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229914_1_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149442_1_v_0_gdpd3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9514
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.3083
2790_EXOSC3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.59384
CERS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57571
GSE149124,GSE149128_3_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
10803_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.653085
chr2_189664505_T_C_b38	GTEx eQTL 2025	1.0	1.88326
GSE247862,GSE247863_4_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
D2HGDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40748
CRCGN015_HEPG2_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.01183
ZBTB33	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.8355
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.189
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.4954
GSE132369,GSE132371_1_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE140997_4_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CE-72-GF32_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.368923
CRCGN014_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5318
MAMLD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15221
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
clone9	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.737
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.2336
GRHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.9395
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	153.907
MPI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32755
GSE165682_0_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.555973
Hepatoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE94849_7_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WDR91	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.56371
RAB8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82526
SRPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43175
Runx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.892
GSE229973_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NR2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2922
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8447
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.3478
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE104022_3_v_4_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE200673,GSE200691_2_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148066,GSE157787_0_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
chr2_189640971_C_T_b38	GTEx eQTL 2025	1.0	1.0637
GSE214823,GSE214824_0_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DE-01-HO61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.324453
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_8_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45751
ISX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7006
HNF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.5318
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	52.954
GSE180200,GSE180201_5_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE89154_1_v_0_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CEBPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.9485
GSE232631_5_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190186,GSE190188_8_v_5_apoe_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152432_6_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Twist2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.8526
RBPMS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8037
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.6822
GSE234289_4_v_1_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8315
GSE136622_7_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130217_5_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FB-85-ND09_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215218
GSE215351,GSE215794_4_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-24-UO04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.419005
Dmbx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.204
CRCGN015_HEPG2_48H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.44997
Ascl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	54.9352
7424_RPAP3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.763765
GSE239768,GSE239769_1_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193993_0_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE63048_11_v_8_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Plant primordium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.633
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.51075
4043_IFITM3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.636653
CRCGN009_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.60701
GSE130396_1_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216538_1_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.1405
Zic3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	56.2869
pre-snoRNP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.318
GSE84462,GSE84762_0_v_1_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE161170,GSE161268_1_v_3_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9032
CRCGN015_HEPG2_48H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.64949
Hippocampus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.126
EC-98-YS67_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227979
Atoh1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.589
GSE155162,GSE155169_1_v_2_buparlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.773
GBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2329
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.69969
Somatic embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.123
MPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9112
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.393528
CRCGN014_HEPG2_24H:D13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.71188
GSE218949_0_v_1_cep20_human	RummaGEO Gene Perturbation Signatures	1.0	null
g2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.174
Lhx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	46.75
GSE121824,GSE121826_0_v_6_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
Esophagus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.126
CRCGN014_HEPG2_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.94675
CRCGN016_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.14915
Gall bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.126
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Npas2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.232
496100653_PCx_probable Alzheimer's disease_no TBI_82_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.28127
AB-04-NN16_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256418
PIP4P2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55512
Shox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.0676
BRINP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23236
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.813409
SHOX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6925
GSE178714_5_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110178_5_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ACSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.096
CRCGN009_HEPG2_24H:L07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.207
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8922
Pax7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	67.7705
ATG4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.443
UBQLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40729
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.715734
HAUS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.102
KMT2E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96052
GSE232558_0_v_1_fbxl12_human	RummaGEO Gene Perturbation Signatures	1.0	null
IC-05-AW29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.452976
GSE163297_0_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.24432
Alx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.1792
GSE97278,GSE97280_2_v_3_nsd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE166169_2_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TENT4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07044
GSE190235_0_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.3723
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228653
CRCGN015_MCF10A.WT.HP_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.66768
GSE247862,GSE247863_0_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE101767_1_v_0_wdr11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74006
TIRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6991
GSE68155_1_v_0_gpr3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE155836,GSE155839_3_v_2_alvocidib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148252_7_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NR6A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.134
HB-24-GP45_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255167
Six3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.6187
GSE151090_2_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Apical hook	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.059
GATA1::TAL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.3053
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214021
GSE203060_0_v_2_kdm4c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
STRBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.08574
CAMKV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47163
ZNF281	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42152
GSE181821_1_v_4_mov10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE139966_5_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234289_5_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.78385
Salivary gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.1
GSE228727_2_v_0_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE222574_0_v_2_lmna_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190186,GSE190188_0_v_5_apoe_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.31788
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5032
GSE240027,GSE240030_5_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0555
CRCGN015_MCF10A.TP53.M_24H:B20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6338
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.5896
GSE48812_2_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.6996
GSE164874_5_v_3_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE121824,GSE121826_0_v_8_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
Ribulose bisphosphate carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.652
POU1F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	105.58
Floral primordium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.79
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9568
CEBPD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07274
Epithelioma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Phragmoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.998
ZNF24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.0039
CRCGN016_MCF10A.TP53.M_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4213
ATP8B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61696
CRCGN011_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0348
Seminal vesicle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.126
NEUROG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2176
496100645_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.06595
CRCGN009_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09127
URGCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5021
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_2_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4656
RARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.8696
GSE226249_5_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BHLHE40	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4478
CRCGN015_HEPG2_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.13126
BC-06-OP01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22749
CRCGN009_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9744
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9425
EMX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5813
GSE210885_2_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.27
ATF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2996
GSE215849_2_v_1_muc1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.4142
MPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72316
Thorax	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.126
CRCGN016_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.15119
GSE226584,GSE226589_3_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242199_6_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE95688_7_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.05396
GSE133683_1_v_5_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7845
GSE142430_2_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.66661
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6932
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	145.833
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.65339
GSE155087_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE179002_4_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CA-98-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254665
PROP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.7373
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HNF1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4478
GSE182921_0_v_1_slit2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CC-90-EX35_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200695
TFDP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.6143
CRCGN016_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1539
PMC11772884-41421_2024_747_MOESM6_ESM.xlsx-7_DEGs_USF2-KO_vs_control-Gene_Symbol_USF2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE159728,GSE159730_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE101546_3_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119978,GSE180930_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prefoldin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.721
GSE184892_0_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.88065
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.01541
CRCGN015_HEPG2_48H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30852
GSE169205_3_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
chr2_189713378_G_A_b38	GTEx eQTL 2025	1.0	1.98084
1013_C18ORF32_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.732812
CRCGN016_MCF10A.WT.HP_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47234
GSE100102_0_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE70499_5_v_1_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE255680_2_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.5622
WC-59-RG09_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.419691
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9987
GSE146074_9_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF558	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	165.078
Histone locus body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.788
CRCGN016_MCF10A.TP53.M_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8722
GSE217694_3_v_2_pold1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Shoot apical meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.78
Arid5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.1851
CRCGN016_MCF10A.TP53.M_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01001
CRCGN015_HEPG2_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.94565
ERMAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06739
ZNF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.516
CRCGN016_MCF10A.WT.HP_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08706
GSE134375_0_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.15964
GSE140607_5_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE229309,GSE229314_4_v_1_elavl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.8926
CDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	93.3591
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0556
RA-49-ZB08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257902
ZNF582	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.57
Adrenal gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.126
GSE102505_1_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.7757
GSE102505_5_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112860_0_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GC-40-VJ01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287323
FOXG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.5241
CRCGN015_MCF10A_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06881
GSE173232_1_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PGAM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82824
Nkx3-2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.7902
CRCGN015_HEPG2_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14099
GSE116492,GSE116495_3_v_2_stag2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14885
EE-98-PF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245147
GSE84678,GSE93902_1_v_2_bcl11b_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32445
RNF141	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27533
COTL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49699
POU5F1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5735
GSE172016_2_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
MEIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.6805
CRCGN015_HEPG2_48H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.47119
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7965
ANKRD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45092
RAB3GAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88741
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.36288
NDUFA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89741
FOS	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	104.803
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.85751
GSE215351,GSE215794_1_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4126
FOXN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4589
PRKD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24307
GSE203158_5_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE139975_3_v_1_rnf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182185_0_v_1_pstk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110178_1_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE93309_1_v_3_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBED2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.4171
CRCGN012_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.97795
GSE180200,GSE180201_5_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE241701_4_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.34377
ORC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92685
CRCGN015_HEPG2_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.59209
PRMT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62194
GSE144500_8_v_2_ventx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135244_0_v_1_trdmt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DNAJC16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71075
GSE138841_0_v_1_trim6_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOSB::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2288
GSE172019_2_v_8_rnf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SOWAHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8585
GSE171837_0_v_3_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BD-96-HO33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.07339
GSE206516,GSE206518_1_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.439492
FOXD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.6
GSE202587_1_v_0_xrn1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ptf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	129.133
GSE161295_2_v_5_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ALX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6183
GSE137144_5_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216988,GSE216989_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE152055_0_v_1_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97218
GSE222758_0_v_3_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HIC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.13165
CRCGN015_HEPG2_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.53421
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.3853
CRCGN015_MCF10A_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.4073
DDX3X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86359
AB-84-PK04_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.374233
CRCGN014_HEPG2_3H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01952
GSE246660_1_v_0_lmo3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166783_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOSL1::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.6021
2226_DIMT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.665292
IRF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.4719
CRCGN008_HEPG2_24H:G24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2904
CRCGN010_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.36176
CRCGN016_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.79257
GSE164483_2_v_0_venetoclax_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE200673,GSE200691_2_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NFIL3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.0598
GSE149760_3_v_5_elof1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16738
FOS::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.0466
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ikzf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.8462
Zic1::Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	45.9353
SMIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67912
GSE171837_3_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RHNO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33069
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CA-16-ZL71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.453696
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5438
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.430823
GSE224157_3_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03969
ZIM3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	106.564
GSE150895,GSE150896_0_v_1_kif15_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FE-64-KC49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.418472
HNF4A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.1755
GSE134316_1_v_0_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.70123
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.0965
Oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.126
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216363
Lsm2-8 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.013
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5091
GSE199899_3_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7039
ZSCAN16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.3052
GSE227592_6_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
PYGM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20974
CRCGN015_HEPG2_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.83482
GSE161846,GSE161849_3_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140937,GSE140938_1_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
BACH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1689
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_HEPG2_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.49443
Sense organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.141
CHSY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47385
GSE236262_2_v_1_trim28_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206226_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE110178_4_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
3788_HIST2H2BE_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.621616
DF-11-IL69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26765
ETV2::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1361
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
9686_UTP3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.675391
GSE149903_5_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.423
GSE203308_9_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BLOC1S6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91553
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.7532
GSE236003_2_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174701_5_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.13035
GSE124375_13_v_12_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Exocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.1
PRRX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4728
CRCGN014_HEPG2_24H:D03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.55149
CRCGN017_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1887
SLC7A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33131
U2AF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91895
NC-27-AD53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255183
GSE211177,GSE211178_9_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pou5f1::Sox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	56.7559
GSE145311_0_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE246195,GSE246305_2_v_5_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54429
Neurod2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.7239
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264027
MSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7853
PHOX2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.693
GSE197257_0_v_1_gpd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NMD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54015
GSE166783_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157S_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE232631_4_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF667	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1752
NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.257
H2AZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70368
DB-21-FY25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.351715
GSE226439,GSE226441_6_v_2_hnf4g_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
TGFB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39417
MIS18A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22488
C8orf58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77473
CRCGN016_MCF10A.WT.HP_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3446
Ahr::Arnt	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.25
GSE158834_1_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
MTHFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11315
AB-84-PK04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.994616
CRCGN017_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2011
GSE220613_0_v_1_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153836_14_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Bach1::Mafk	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	64.5263
INTS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0479
CRCGN011_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0972
9482_UBA52_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.519075
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9707
GSE134375_4_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
protein stabilization	GO Biological Process Annotations 2023	1.0	null
CRCGN015_MCF10A_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.6258
GSE138019_3_v_2_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PROX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1852
GSE100102_0_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
REST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84617
AE-14-NN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233583
ZNF211	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.5113
GSE215351,GSE215794_4_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
STAT1::STAT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.6742
ZDBF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61645
DNAJC28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59578
PLEC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29124
GSE205316,GSE205317_0_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100357_TCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.39844
LX-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.759
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.90195
GSE201217_3_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.7057
Rarb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	77.8637
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
KB-72-ID36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286676
Bhlha15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	78.7126
5163_MPHOSPH10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.675346
GSE130690,GSE130692_1_v_0_sirt6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236661
GSE208254_3_v_1_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160246_9_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210885_5_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SOX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2163
LMX1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.835
GSE222758_0_v_1_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE92589_2_v_1_sirolimus_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.67925
GSE248858_4_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GC-69-JF03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261242
TFEB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.698
GSE125007,GSE125008_10_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IRF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.2688
GSE142684_3_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE225869_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GATA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6125
GSE184884_6_v_5_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142684_4_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184087_4_v_1_tert_human	RummaGEO Gene Perturbation Signatures	1.0	null
ESRRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2753
MIB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6094
GSE62843,GSE64370_0_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.539827
BOLA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19253
GSE111881_0_v_1_znf768_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE129858,GSE129859_1_v_3_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Dlx5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	42.3714
Msx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.7952
Rad51B-Rad51C complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.954
GSE112763,GSE112767_2_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Gli1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.7337
CRCGN008_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.51255
SRY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.3929
EID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66236
GSE224877_3_v_0_pctp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2306
MYBL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1234
AGAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53959
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.78601
TNIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58718
CRCGN015_HEPG2_48H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.71524
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213937
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.331725
Box C/D RNP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.881
GSE214823,GSE214824_5_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211226_1_v_2_sirpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TCF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5594
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4022
CRCGN014_HEPG2_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48033
GSE190316,GSE190324_10_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03288
CEBPD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2189
GSE120612_6_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.38415
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
FAM98B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63766
PYGB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84002
SH2D5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6301
GSE203308_6_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CEBPG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.7331
GSE113267_0_v_1_rfx7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Amylin receptor complex 1	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.699
10231_ZNF236_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.507062
MGA::EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6692
GSE201877_1_v_0_yap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100639_TCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.09485
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227891_5_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BHLHE22	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.7855
GSE158320,GSE183351_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12
GSE206729_5_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-96-HO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334958
GSE234289_4_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149264,GSE149267_9_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150215_1_v_2_etl4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210655_1_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KAT2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1603
CRCGN008_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0676
GSE152937_6_v_5_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE137818_2_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GRPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51217
GSE207582_4_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE141453,GSE141454_0_v_4_card11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MFSD2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93614
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.422958
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4893
GSE146253_0_v_5_stat4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Inflorescence meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.736
AE-52-FP96_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260787
TMEM39B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43601
GSE95688_1_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF410	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	86.0609
FOS::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.5648
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100429_TCx_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.51705
GSE158834_2_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-30-OK99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200509
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222985
CRCGN010_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.30295
GSE206729_3_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.6661
GSE148200_4_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246724
BE-27-RQ61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.504008
GSE112761,GSE112767_2_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POU2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.7964
Root apical meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.655
GSE212299_3_v_0_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE236815_1_v_0_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE102505_1_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE96991,GSE97117_4_v_2_il11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RBM26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54489