association	dataset	threshold value	standardized value
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.22242
GTEX-N7MT-0011-R2a-SM-2I3GI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04159
SNU324	CCLE Cell Line Gene CNV Profiles	-1.0	-2.8031
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
BRD-K61486072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4706
VZ in caudal cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.932331
COPD - Chronic obstructive pulmonary disease_Muscle - Striated (Skeletal) - Diaphragm (MMHCC)_GSE475	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.66004
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.38104
Neural Tube Defects	CTD Gene-Disease Associations	1.0	1.19312
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K45941986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51314
HSG	BioGPS Cell Line Gene Expression Profiles	1.0	1.24506
BRD-K76680796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01103
limbic system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE182181_1_v_0_ricolinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CREB3L4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4084
CTCF_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
parbendazole-3881	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_13058_Mut|OE_Sik3E13_SRP334442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.10278
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KASUMI1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.04852
CDAN1_02_197	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.87447
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.920113
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1Z4-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
clomipramine-6825	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE152734,GSE152735_2_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.4231
GTEX-SE5C-0626-SM-2XCDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08293
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Atherosclerosis	CTD Gene-Disease Associations	1.0	1.24812
alprostadil-4179	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
luteolin-6658	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_3854_KO_ITPR3_SRP332879	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.66237
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OPM-2	GDSC Cell Line Gene Expression Profiles	-1.0	-1.47337
GSE213588_8_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HPAF-II	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.875343
Perturb_12048_KO_LSD1_SRP310135	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-14.5094
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998595
appendix	HPA Tissue Protein Expression Profiles	-1.0	-0.867575
GSE223908,GSE223909_1_v_3_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171352_2_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K73210450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00068
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37696710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49547
BRD-K97339945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02836
H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
GTEX-X4XX-3026-SM-3NMB2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.8745
Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A40U-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE261563_5_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
posterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14294
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06346
CD83	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12406
GTEX-XLM4-0011-R3B-SM-4AT6E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895095
methanthelinium bromide-6254	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.91471
MERO25	DepMap CRISPR Gene Dependency	1.0	3.30422
SAT	DepMap CRISPR Gene Dependency	1.0	2.04391
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K90702609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23445
GSE157635_1_v_0_trem2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14349
rostral subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.54919
RPMI-6666	COSMIC Cell Line Gene Mutation Profiles	1.0	null
trichostatin A-7499	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
HCC1187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.74467
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67K-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11446
FGFR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13961
GTEX-X4XX-0011-R2A-SM-3P623	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21779
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_Capecitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163431
BRD-A31576716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.039
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.495
CP-690334-01-4558	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LMNB1_02_195	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.80735
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13926
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.860825
GTEX-WVLH-0011-R6A-SM-3MJFZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31878
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_MCF-7_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Congenital Abnormalities	CTD Gene-Disease Associations	1.0	1.07518
Lung adenocarcinoma_LUAD_TCGA-55-8097-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_11443_KD_METTL3_SRP292228	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.37013
GTEX-N7MS-0011-R5a-SM-2HMK8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43501
GSE210101,GSE210114_2_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39897
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1ME-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_fibroblast of lung_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE233679_14_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
troglitazone-1657	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AB-71-CI37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.305696
ChIP_H3K27me3_17603471_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
A549_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141882
BRD-K25982056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01912
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.25682
Pancreatic adenocarcinoma_PAAD_TCGA-LB-A7SX-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Congenital nervous system abnormality	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.274
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WL46-0011-R6A-SM-3LK6X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938991
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Rixosome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.962
Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F7-01A-11R-A084-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A0S7-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E1-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TE-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K91952416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00486
Endoplasmic reticulum-Golgi intermediate compartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.939
BRD-K60848736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11984
GSE173201_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE128333_3_v_5_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE102467_1_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OHPN-0011-R5A-SM-2I5FF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892851
GSE233183,GSE233187_2_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KP3	CCLE Cell Line Gene CNV Profiles	1.0	1.35001
clonidine-6814	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11067031-pnas.2317690121.sd06.xlsx-gene_list_14_txt-Differentially_expressed_genes_between_PML_RARA_GFP_vs_C88A_PML_RARA_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Deuterosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.688
outer portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07575
A549_G007-LK_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119996
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HPAC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16216
suxibuzone-7163	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CREB1-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal tooth morphology	MGI Mouse Phenotype Associations 2023	1.0	null
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ1-0226-SM-33HB5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89915
HCC1569	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.01293
H3K4me1_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WHSE-0011-R6A-SM-3P5ZP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30539
GTEX-R55E-0011-R7A-SM-2TC5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41269
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1HY-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USF1_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_BE2C_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IR-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cepharanthine_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0230227
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsal motor nucleus of the vagus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1095
GSE232218_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.78752
SP1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in midcingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.854174
phensuximide-5522	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-O1-A52J-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7Q0-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
N-Myc	MotifMap Predicted Transcription Factor Targets	1.0	null
PAK4	Kinase Library Serine Threonine Kinome Atlas	1.0	null
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.969748
Lung squamous cell carcinoma_LUSC_TCGA-37-4129-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EC-62-OE64_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.470679
GSE213588_8_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5162773-892	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD8+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.984025
CTCF_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of villous mesenchyme_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF263_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PTGR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51947
precommissural nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.833581
CTCF_mammary epithelial cell_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K38972344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00864
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
SYNCRIP_OE_GDS1886_83_human_THP-1 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
496100406_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00595
FAM98B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77865
CTCF_fibroblast of mammary gland_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMS-26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.856389
Velum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.704
cerebellar cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11354
GTEX-S7SE-0005-SM-2XCEA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93743
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PML	ENCODE Transcription Factor Targets	1.0	null
GTEX-XOTO-2926-SM-4B65G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04696
betonicine-4767	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
esophagus_5c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.68083
DU 145	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.859659
BRD-K74665927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41167
Perturb_16850_KO_Hnrnph1_SRP068520	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.00886
CTCF_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2106	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19804
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.847014
GSE195568_1_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06435
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_6758_Mut_TOP3B_SRP345494	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE120612_6_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MDA-MB-435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.998169
GTEX-RNOR-2226-SM-2TF5O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.966429
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.07482
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Differentially_expressed_genes_identified_in_bulk_RNA-seq_of_FOXO1-_-_vs_FOXO1_hMSCs_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P78B-1626-SM-2S1O1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
NCIH211	DepMap CRISPR Gene Dependency	1.0	2.59327
oculomotor nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04947
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
TAF2-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-5241-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_5980_KD_XRN2_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.0427
GTEX-WFON-0326-SM-3GIKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
VZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16199
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-0011-R5A-SM-3NB3E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904756
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tropicamide-3722	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.68083
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4319	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.941073
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.328764
GTEX-QVJO-0011-R9A-SM-2S1QH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950092
Depressive Disorder	CTD Gene-Disease Associations	1.0	1.13075
GTEX-QVUS-0011-R9A-SM-3GIJA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896739
PFEIFFER	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.38433
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A4-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4595011-pgen.1005555.s003.xlsx-MITF_UP-regulated-Ensembl_gene_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K09819684	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33417
SESN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3729
pergolide-7434	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
harmalol-5076	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hexylcaine-2708	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01721
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
NCI-H446	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.48108
GSE202434,GSE202438_9_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PDE6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25925
GTEX-RVPV-0226-SM-2TF6W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83263
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.868921
SUZ12	ChEA Transcription Factor Targets	1.0	null
hsa-miR-575	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
SOX3-22085726-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
RAJI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.61172
BRD-K68836091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03209
BRD-K31721388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25322
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
securinine-3470	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
9242_TRAPPC11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.52766
neomycin-7221	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00352
ZNF281	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	280.104
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.56996
KLF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	159.078
GTEX-TSE9-3126-SM-4DXSY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852682
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane part	GO Cellular Component Annotations 2015	1.0	null
trapidil-7475	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.38555
metampicillin-5115	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SP-01B-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6379364-41598_2018_37489_MOESM2_ESM.xlsx-Sheet2_DESeq_MSC_vs_fibroblast-Unnamed_1_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Autism spectrum disorder or schizophrenia	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.939794
CD-20-MH57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211583
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09989
H3K9me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE186223,GSE186224_6_v_3_hmces_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214931_4_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOS	ENCODE Transcription Factor Targets	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M3-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WVLH-0011-R11A-SM-3MJFO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02737
hecogenin-7175	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WYVS-2526-SM-3NMAT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06171
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K59913416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30877
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.26585
REST_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242083,GSE242098_3_v_4_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-N7MS-0011-R7a-SM-2HMKN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63946
ampyrone-6845	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE152441,GSE152442_6_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.692297
Bicalutamide_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0136396
orbital frontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.85044
BRD-K83013052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43436
Acute Myeloid Leukemia_LAML_TCGA-AB-2810-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16509
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.40247
BRD-K96411295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0545
PMC6715699-41467_2019_11785_MOESM4_ESM.xlsx-CSL_KD-Genes_differentially_expressed_upon_CSL_silencing_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5414054-ncomms15013-s11.xlsx-SupplementaryData10-Supplementary_Data_10_Genes_differentially_expressed_due_to_infection_in_IRF5-_-_compared_to_parent_KOLF2_cells_IRF5	Rummagene Transcription Factor Associations 2026	1.0	null
OVCA 429	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.859659
Perturb_5977_KD_UBE2I_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.088
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04316
SUGP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01695
GSE256181_2_v_0_etv2_human	RummaGEO Gene Perturbation Signatures	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
NCVADR RES	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.873435
SIRT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0679
PMC6379364-41598_2018_37489_MOESM2_ESM.xlsx-Sheet2_DESeq_MSC_vs_fibroblast-DESeq_MSC_vs_fibroblast_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
IDH3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46209
hydroflumethiazide-1687	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2BK12ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MYC_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE175787_4_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
bezafibrate-4999	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
REST_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92269212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43023
KDM5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88617
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
orphenadrine-3801	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCOR-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC7581777-41419_2020_3029_MOESM6_ESM.xlsx-MNX1_ChIP-Symbol_MNX1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.829348
Lung squamous cell carcinoma_LUSC_TCGA-56-8624-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
P68-20966046-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5435-01A-01R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216273,GSE216292_14_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ATF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K64767126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24407
Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.832986
BRD-K34445094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58594
HCC1937	CCLE Cell Line Gene CNV Profiles	1.0	1.49627
BRD-K45813167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36049
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3B6-01A-21R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	1.63832
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.940805
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.964108
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.31529
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5ER-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
SON	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03847
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3442_KO_Mll4_SRP101279	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.49224
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cyclocytidine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79049
IRF1	ENCODE Transcription Factor Targets	1.0	null
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.900294
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
Pancreatic adenocarcinoma_PAAD_TCGA-YY-A8LH-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
supraoptic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17354
EBF1	ENCODE Transcription Factor Targets	1.0	null
MRPL41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65165
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24808
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
delsoline-7212	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OXRO-0011-R9A-SM-3NB1X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.936935
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I0-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SARC9371	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Spondylocostal dysostosis 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.61
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
pyrvinium-978	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC12769604-13402_2025_1147_MOESM6_ESM.xlsx-Table_S4_3_Venn-Tumor_AND_Prognosis_NOT_Scissor_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K04409515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00265
Prestwick-967-7346	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prestwick-674-3716	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
SOX2-20726797-SW620-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Motor Skills Disorders	CTD Gene-Disease Associations	1.0	1.17366
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEX19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27586
H3K27me3_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05098
Insulin Resistance	CTD Gene-Disease Associations	1.0	1.28149
Vitamin K4_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00629825
hydroxyzine-5006	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WZTO-0011-R5B-SM-3NMC5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14145
BRD-K99944747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11381
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.83182
BRD-K44131977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35153
TA-25-KO99_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.429783
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
JAK2_mutant_40_GSE11003	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.81863
BRD-K32124229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12115
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
roxarsone-5051	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C7-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH716	CCLE Cell Line Gene Expression Profiles	1.0	1.48318
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
midbrain raphe nuclei	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.01055
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.92216
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-V1-A8ML-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
spiradoline-3818	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K28414977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67429
GSE148263_6_v_0_trim3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H2810	COSMIC Cell Line Gene Mutation Profiles	1.0	null
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.9609
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CD-01A-21R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
2321_DNTTIP2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.02906
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
sulfafurazole-5257	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WC-67-DI84_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203418
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_2-Methoxyestradiol_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.00990695
lower (caudal) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.35642
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K84062787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70601
PRDM9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	244.613
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
3436_RACK1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.37308
GSE125219,GSE125221_4_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
EB1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19133
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.43
EBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.352
PMC11908325-media-2.xlsx-Table10_MR-Unnamed_7_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
trimethylcolchicinic acid-2802	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.929292
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16916
GTEX-QCQG-2126-SM-2S1P8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
BICR31	CCLE Cell Line Gene CNV Profiles	1.0	1.65405
LNCAP	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.952088
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08489
GTEX-POYW-0526-SM-2XCEY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86798
BRD-K29935988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51842
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
genistein-1073	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-U3ZM-0626-SM-4DXTV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.905812
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6960-01A-41R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COV318	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.61271
GSE145915_5_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.989494
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gastrointestinal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.946
lateral hypothalamic area, anterior region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00625
Weight Gain	CTD Gene-Disease Associations	1.0	1.39897
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
GSE138938_1_v_3_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.30545
lithocholic acid-4373	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SNRK_overexpression_127_GSE30185	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.32378
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Schizophrenia	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.0301
L-methionine sulfoximine-2831	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
foliosidine-3636	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19793
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OCI-AML5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.78124
GSE202434,GSE202438_3_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.61801
solitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19041
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CREB1-23762244-HIPPOCAMPUS-RAT	ChEA Transcription Factor Binding Site Profiles	1.0	null
Stomach	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.60155
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
GSE221327_10_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OL-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07552
H3K4me3_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
COLO 205	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K54484272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27791
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
spinal trigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.43134
GTEX-WVLH-0011-R5A-SM-3MJFW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11066
GTEX-T2IS-0011-R11A-SM-32QPC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.960727
20368555-TS-4	GeneSigDB Published Gene Signatures	1.0	null
PSMD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26081
SNU-475	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4017
BRD-K73994499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11572
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.923748
GSE213588_10_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OOBJ-1826-SM-3NB1C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07087
H3K4me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
19658189-TableS4	GeneSigDB Published Gene Signatures	1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24771
aminophylline-6295	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC3046820-supp_db10-1270_DB101270SupplementaryData2.xls-Table_2S_Adioose_AA_vs_EA-Unnamed_1_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K38955287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17729
PMC7941712-40478_2021_1135_MOESM12_ESM.xlsx-Table_S4D_DEG_ST-EPN-RELA-Unnamed_6_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
H3K79me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
alfaxalone-6514	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
hsa-miR-125a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.02471
GTEX-WL46-0011-R11A-SM-3MJFT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44615
BRD-K10989739	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18913
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.11087
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
oxaprozin-4530	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.966149
inner portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02957
CRCGN017_MCF10A.TP53.M_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0552
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1192
GSE147876,GSE147877_4_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE152441,GSE152442_1_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
N-acetyl-L-leucine-5683	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE195568_3_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_16651_KD_Fus_SRP179634	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.72758
GSE233679_14_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SW-403 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.693
PMC12478272-mmc1.xlsx-Table_S7-Supplementary_Table_7_Proteome-wide_MR_and_sensitivity_analysis_results_using_the_brain_pQTL_dataset_from_Wingo_et_al_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
stomach	GTEx Tissue Gene Expression Profiles	1.0	0.904141
GTEX-N7MT-0011-R6a-SM-2I3G3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08002
1774_COPG1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	4.59287
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-fromNode_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K92359570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38339
Prostate adenocarcinoma_PRAD_TCGA-H9-A6BY-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S7SE-0011-R4A-SM-2XCDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01986
brain_3c	HPA Tissue Sample Gene Expression Profiles	1.0	1.69891
BRD-K08576275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79959
A549_Divalproex Sodium_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131528
PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-upregulated_in_ATF4OE_txt-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE153354_0_v_1_tcf19_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RNOR-0926-SM-2TF56	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89583
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_fibroblast of villous mesenchyme_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE144231_6_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_20_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5084-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202434,GSE202438_15_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XOTO-0011-R5A-SM-4B657	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02923
VZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.65157
UBE2V2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47345
GTEX-X4XX-0011-R6B-SM-46MWP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02643
AH-23848-6885	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gastric	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.21885
GTEX-R55E-0011-R6A-SM-2TC5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17408
MKN7	CCLE Cell Line Gene CNV Profiles	1.0	2.59998
COV644	CCLE Cell Line Gene Expression Profiles	1.0	1.64281
ciclacillin-4536	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.01625
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MEL290	DepMap CRISPR Gene Dependency	1.0	2.07049
BRD-K24669989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55018
BRD-K32760954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06884
REL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8824
PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_-2-1280_genes_are_more_than_four-fold_downregulated_in_PRDM8-_-_compared_to_control_PRDM8	Rummagene Transcription Factor Associations 2026	1.0	null
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tretinoin_homo sapiens_gpl6244_gds4180	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Right_Ventricle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.886355
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
desipramine-5292	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K49704392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29734
SCO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08254
GTEX-QEG4-0426-SM-33HC3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
PMC4595011-pgen.1005555.s001.xlsx-BPTF_UP-regulated-Gene_name_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
icSARA deltaORF6_60Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.58935
GTEX-NPJ7-0011-R9a-SM-2TC5R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95896
GSE131660_2_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Charcot-Marie-Tooth disease type 4H	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
A549_Resveratrol_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015976
Brain - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.616316
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PANC1	BioGPS Cell Line Gene Expression Profiles	1.0	1.07811
BRD-K35119180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44086
frontal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.941904
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81A-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_15_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.87065
ChIP_SIN3A_21632747	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-RM2N-1626-SM-2TF5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907009
BRD-K24532125	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60825
SUM-102PT cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.345
GTEX-WHSE-0011-R11A-SM-3P5YY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14537
BRD-K83815065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04006
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Thymus	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.04769
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51N-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.838479
Adrenocortical carcinoma_ACC_TCGA-OR-A5KV-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE96649_1_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FT-A3EE-01A-11R-A206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.846225
GTEX-RNOR-2326-SM-2TF4I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16973
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
NAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22726
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9314667-Table_1.xlsx-Regulons-TFAP2B_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
stomach_3a	HPA Tissue Sample Gene Expression Profiles	1.0	1.09123
BRD-K87743988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09768
GSE239688_2_v_5_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Psoas_Muscle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.31931
GSE239844_7_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
3-acetylcoumarin-4664	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185717
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290819
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.688
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.843
GTEX-V1D1-2026-SM-3GAF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
levocabastine-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54267
GSE193258,GSE193259_2_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC1187	DepMap CRISPR Gene Dependency	1.0	3.15961
MAX_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02857
GTEX-TML8-1826-SM-32QOR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.867188
calmidazolium-906	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Givinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136095
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior hypothalamic area, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.9231
GSE158715_2_v_4_cyp1b1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873491
GSE161800_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0169
GTEX-TSE9-0011-R7A-SM-3DB7P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08374
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1799
GTEX-WFG7-2226-SM-3GIKP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
BRD-K74892102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47643
Prostatic Diseases	CTD Gene-Disease Associations	1.0	1.10388
0179445-0000-3733	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lateral parabrachial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02077
theophylline-4812	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
butoconazole-3288	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SP4	ENCODE Transcription Factor Targets	1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
19185848-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Abdominal obesity-metabolic syndrome	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.096
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.885351
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19011
7505_RPS16_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01594
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.33254
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A3GM-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE77108_4_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE199899_1_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE221327_8_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17583
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
CA-42-YI34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.332656
ATF3	MotifMap Predicted Transcription Factor Targets	1.0	null
Perturb_13983_KD_Ago2_ERP125823	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.83957
JUND	ENCODE Transcription Factor Targets	1.0	null
GSE144231_3_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100652_PCx_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.30242
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.895407
ELK1	ENCODE Transcription Factor Targets	1.0	null
HNRNPL_02_160	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.11548
motor nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.0164
primary auditory cortex (core)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.834921
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22765
CTCF_BE2C_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWCY-0426-SM-48TCW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.912289
SIN3A_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NSMF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5739
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ceforanide-6751	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K27945483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03122
SLC25A24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04557
CD71+_EarlyErythroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.0163
BRD-K30217326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96092
PMC5795782-supp_gad.302646.117_Supplemental_Table_S1.xlsx-Table_S1_1-Supplemental_Table_S1_1_Genes_significantly_downregulated_by_ARID5B_knockdown_ARID5B	Rummagene Transcription Factor Associations 2026	1.0	null
MAFK	ENCODE Transcription Factor Targets	1.0	null
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.390322
deferoxamine-3417	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XMD1-0011-R1A-SM-4AT4C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947763
GSE253795_1_v_0_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193258,GSE193259_5_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GR-ST	GDSC Cell Line Gene Expression Profiles	-1.0	-2.25359
A549_Ki16425_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142938
HCC1395	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.719678
H3K4me1_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE157609,GSE158123_0_v_1_ifi16_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
BFTC-905	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.859659
SK-MEL-28 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.754
A549_PFI-1_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0101308
alprostadil-4099	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lynestrenol-5355	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-HQ-A2OF-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TKQ2-1026-SM-33HB7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.929258
AURA	Kinase Library Serine Threonine Kinome Atlas	1.0	null
GSE207302,GSE207303_0_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Ellagic acid_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0223051
UBE2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03516
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11755
BRD-K12918607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29479
GSE125862_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.893527
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37740343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1168
MHH-PREB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-46-3769-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
milrinone-7210	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5555-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE230744,GSE237803_5_v_2_hira_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7051_RABGGTB_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.14578
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_retinal pigment epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
caudal subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01524
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
ctnnb1_21914722_ls174t_lof_human_gpl570_gds4386	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.19869
BRD-K05392698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25684
GB-73-QS80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.630879
BRD-K90004516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06835
NCI-H650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.54836
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mebhydrolin-4211	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC5013636-ncomms12601-s5.xlsx-SP1-Groups_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0011-R1A-SM-32PM6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51398
USF1_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
peptidyl-amino acid modification	GO Biological Process Annotations 2015	1.0	null
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JUN	ENCODE Transcription Factor Targets	1.0	null
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pilocarpine-5341	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_9728_KD_CDYL_SRP234405	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
naftifine-7032	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.09445
CTCF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K65361030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35572
KDM4A	ENCODE Transcription Factor Targets	1.0	null
smooth muscle	HPA Tissue Protein Expression Profiles	1.0	1.02578
GSE195514_0_v_1_stk25_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K54939987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12862
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03242
GTEX-XMD1-0011-R10A-SM-4AT4A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03682
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_y_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
valproic acid-6929	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RU72-0011-R6A-SM-2TF71	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23641
BRD-K33597325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55966
A549_UNC1999_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139916
CDH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32981
corpus callosum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0688
pedunculo(pontine) tegmental  nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.895217
REST_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K31487236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06251
Smith-Magenis syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.162
BRD-K64132098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84556
decitabine-920	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
gabapentin-7229	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
valinomycin-5911	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-QVJO-0011-R10A-SM-2S1QJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892511
ADRB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22549
FOSL2	ENCODE Transcription Factor Targets	1.0	null
NFE2L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09229
TXNL4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05322
BRD-K84935903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82191
anterior hypothalamic area, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.51792
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RJ-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.931606
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.75772
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17646
GTEX-S4UY-0526-SM-3K2AN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908751
SAFB_02_11	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61667
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE118490_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SP5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.7057
GSE200430_1_v_0_sema3d_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4595011-pgen.1005555.s003.xlsx-BPTF_UP-regulated-Gene_name_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.386338
BRD-K46155894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05875
9245_TRAPPC1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03299
BRD-K10092312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27141
17638893-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
SIN3A_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PAX5	ENCODE Transcription Factor Targets	1.0	null
GTEX-WHSE-0011-R5A-SM-3P5ZO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976254
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952819
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE202434,GSE202438_4_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-N7MS-0011-R8a-SM-2YUMK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90111
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.45286
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.992716
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.40264
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1-23762244-HIPPOCAMPUS-RAT	ChEA Transcription Factor Targets 2022	1.0	null
sulfinpyrazone-6230	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5151277-903	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NFYA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X585-0011-R5A-SM-46MVI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16625
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.39907
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X585-0011-R2B-SM-46MVF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09915
GTEX-WOFM-1326-SM-3MJFR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843567
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.6473
pyrvinium-3518	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_fibroblast of pedal digit skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147876,GSE147877_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH1869	DepMap CRISPR Gene Dependency	1.0	5.9081
BRD-K38189984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16813
Mayer-Rokitansky-Kuster-Hauser syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.348
principal sensory nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0434
wortmannin-869	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
BRD-K89260735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37057
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
TPRKB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7344
GSE152441,GSE152442_1_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K25942808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27197
sulfasalazine-6346	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
etanidazole-6211	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K35407043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50209
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXP1	ChEA Transcription Factor Targets	1.0	null
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_16_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A1H6-01B-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QV44-2226-SM-447A3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859728
BRD-K24659381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22936
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.395759
alfadolone-6506	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	193.153
KP1N	DepMap CRISPR Gene Dependency	1.0	3.18424
BRD-K77894681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07129
RFX5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J9-A52B-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EFNA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55547
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.18395
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09273
H2AK5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	51.3106
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
GTEX-R3RS-0526-SM-3GADG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02807
minocycline-5077	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
alpha-ergocryptine-3817	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE168587,GSE168752_3_v_1_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
proguanil-3505	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE220287_0_v_3_mef2d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE191021_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.6747
MAZ	ENCODE Transcription Factor Targets	1.0	null
GTEX-R55E-0011-R11A-SM-2TC6I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853203
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100324_FWM_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.50949
MYCN-28898695-NB1643-HUMAN-NERVE-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE87615_1_v_3_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
dyclonine-7423	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LY-294002-5970	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
9253_TRAPPC8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.68063
Lung squamous cell carcinoma_LUSC_TCGA-34-A5IX-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.972003
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF684	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.4022
BALL-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4992-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H4K20me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RKO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
External side of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.141
LY-294002-5596	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RWS6-0326-SM-2XCAP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.985262
BRD-K07712233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34177
ZDHHC24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43499
Brain_Hippocampus_Middle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	2.68634
GTEX-N7MS-0011-R2a-SM-2HML6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24269
REST_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T2IS-3026-SM-32QPM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988943
5253409-961	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE175787_4_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WEY5-2326-SM-3GIKK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
SF767	CCLE Cell Line Gene CNV Profiles	-1.0	-2.40188
Breast Cancer_Mammary Gland Tissue_GSE1379	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.88938
BRD-K21254338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97332
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me1_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
G118	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BACH1	ENCODE Transcription Factor Targets	1.0	null
GTEX-SN8G-0526-SM-32PLE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00902
tetrahydroalstonine-6209	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB33	ENCODE Transcription Factor Targets	1.0	null
SRF	ENCODE Transcription Factor Targets	1.0	null
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4634137-ncomms9549-s7.xlsx-ZF_Hair_cell_data-Unnamed_1_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WZTO-2926-SM-3NM9I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934509
PMC11409756-13062_2024_533_MOESM1_ESM.xlsx-Sheet1-Table_S1_Differentially_expressed_genes_DEGs_regulated_by_ZFP64_through_mRNA-seq_ZFP64	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.35231
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149035_7_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7535-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAL-27	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4595011-pgen.1005555.s003.xlsx-BPTF_UP-regulated-Ensembl_gene_id_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
HAUS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18591
NFYB	ENCODE Transcription Factor Targets	1.0	null
GTEX-TSE9-0011-R10A-SM-3DB7O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.862444
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE226249_5_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.968832
WM3772F	DepMap CRISPR Gene Dependency	1.0	9.15807
BRD-K24226959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00208
lateral hypothalamic area, mammillary region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0914
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H-89-6878	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.60012
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.23456
GTEX-X585-0011-R3B-SM-46MVG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877422
BRD-K23203419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39815
KYSE520	CCLE Cell Line Gene CNV Profiles	1.0	2.0544
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
spaglumic acid-2962	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
D458	DepMap CRISPR Gene Dependency	1.0	2.13351
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.890502
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76420749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92681
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NFK9-0526-SM-2YUNL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940286
STAT3	MotifMap Predicted Transcription Factor Targets	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NB-01A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.329878
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC202	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.712809
REST_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DNAJC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64757
KYSE-510	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XUW1-0526-SM-4BOP3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85048
T3M3	DepMap CRISPR Gene Dependency	1.0	2.54205
abnormal digit morphology	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-K87815532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00346
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Corpuscular Hemoglobin Concentration Mean	DisGeNET Gene-Phenotype Associations	1.0	null
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.909155
BRD-K51320582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13979
Mayer-Rokitansky-Kuster-Hauser syndrome type 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
EZH2_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Peripheral Blood Mononuclear Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
diazoxide-7168	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WFG8-0626-SM-3GILJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.988147
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4989-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F5-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE134615_1_v_0_lats1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF273	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01577
SKNMM	DepMap CRISPR Gene Dependency	1.0	3.71382
496100532_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04663
GSE175787_11_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K11113009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05253
primary visual cortex (striate cortex, area V1/17)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.27192
pimasertib	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06419
head of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.68861
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.829664
equilin-5255	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE75209,GSE75212_0_v_1_halofuginone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_16649_KO_Tardbp_SRP201975	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPN-0011-R9A-SM-4DXUH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46872
OC314	CCLE Cell Line Gene Expression Profiles	1.0	1.41447
Perturb_17359_OE_CREB_SRP334442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.11238
BRD-K22874335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09922
BRD-A57285050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02729
GTEX-R55E-0011-R1A-SM-2TC6N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999937
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7VF-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.18074
GSE168401_2_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dequalinium chloride-5396	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PF-01378883-00-6368	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MN-0011-R8A-SM-32QP3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57727
GSE174701_4_v_3_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CEBPD_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KRAS.BREAST_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
SCC15	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37892
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.83405
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12071
orphenadrine-4537	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
endoplasmic reticulum	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-WL46-0011-R10A-SM-3MJFQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00703
Perturb_5909_KD_FYTTD1_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.24325
GSE196104,GSE196106_2_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZMYM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10333
CTCF_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142684_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248769_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-1226-SM-2TF6N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849372
RAD21_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of foreskin _hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TML8-1426-SM-4DXUT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843838
rh30	HPA Cell Line Gene Expression Profiles	-1.0	-2.39936
PMC3435504-msb201237-s2.xls-Supp_Table_4a-WT1_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EO-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZIC5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.435
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.53704
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK4_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12178829-mmc4.xlsx-Sheet_4-MEG3-KD_Up-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-ENSG_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K68731395	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2112
GTEX-XOTO-0011-R3A-SM-4B64W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09504
GTEX-WWYW-0011-R7A-SM-3NB3H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15112
cellular_component	GO Cellular Component Annotations 2015	1.0	null
GSE216273,GSE216292_14_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.456
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K60719499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08382
Prestwick-682-4984	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19B-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K26074237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19537
SPCS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53722
BRD-K44363090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46651
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-8277-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19338
BRD-K34929471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11448
CRCGN015_MCF10A.WT.HP_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.50832
GSE121824,GSE121826_0_v_2_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
meclozine-5607	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5888-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDAC2_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
estradiol-5910	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.8029
SLR20	CCLE Cell Line Gene CNV Profiles	1.0	1.86126
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Autosomal dominant disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.096
HC-01-FD24_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.320199
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YS-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
preoptic region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15633
hsa-miR-4676-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
BAS-012416453-6880	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ8I-0826-SM-4BOOE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
H3K4me1_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PSMB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24695
GTEX-RWS6-2126-SM-2XCAV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
GTEX-TSE9-0011-R9A-SM-3DB7Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902119
Spinalcord	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.937112
CTCF_epithelial cell of esophagus_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0011-R11A-SM-32QOX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839752
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.836137
Velocardiofacial syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.123
isocarboxazid-3684	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM12873_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PANC1005	DepMap CRISPR Gene Dependency	1.0	2.99765
PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN2_n_EN2	Rummagene Transcription Factor Associations 2026	1.0	null
palmatine-4957	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K26647686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53097
cefalotin-6079	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
scopoletin-6510	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE90552_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_13835_KO_Cpeb1_SRP095340	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.92108
GSE239688_4_v_0_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TAF1	ENCODE Transcription Factor Targets	1.0	null
H1 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.930749
Schizophrenia 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.539
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.90746
ZBTB33	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.722
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3306-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S7SE-0011-R11A-SM-2XCDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08432
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5175-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.31616
GTEX-RTLS-0526-SM-2TF64	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23796
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.93513
GSE210682_0_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
IF-31-RN78_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.435872
IL15_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K98793503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28453
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.886855
H3K4me1_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RUNX3	ENCODE Transcription Factor Targets	1.0	null
haloperidol-1024	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SLR25	CCLE Cell Line Gene Expression Profiles	1.0	1.61235
BRD-K15285842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62423
GSE62843,GSE64371_2_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PSDG-0526-SM-2S1OH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
GTEX-N7MS-0011-R6a-SM-2HMJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3765
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.27357
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
Mammary Neoplasms, Animal	CTD Gene-Disease Associations	1.0	1.09332
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WH-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.93177
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.40429
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K20me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12873_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-0011-R9A-SM-4GICI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.932636
ikarugamycin-918	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.940918
GSE48812_7_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
lateral parabrachial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.994051
BRD-K69038251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41332
VMRCRCW	CCLE Cell Line Gene Expression Profiles	1.0	1.887
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4735-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A9WH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsal thalamus_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.828989
probenecid-2825	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K88539660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60877
BRD-K77978259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23845
GTEX-UPK5-0326-SM-3GAF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
genistein-4459	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
GSE236228_0_v_1_penfluridol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.62468
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K37830990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21276
bezafibrate-6653	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Fetal_Brain_Female	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.862816
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5096-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EXOC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14421
FOXP1-21924763-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K55852567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70155
BA-68-FJ41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202939
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.89844
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30383
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE191037_0_v_1_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BDCA4+_DentriticCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.3297
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUU-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SUM159PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.713321
GSE238018_3_v_2_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE102467_1_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838662
clorgiline-6659	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LOX-1_OE_GDS4262_432_human_HAECT - aortic endothelial cell line - 2 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.958408
GSE157383_6_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.273
phthalylsulfathiazole-5249	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K21635266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.33343
TP53	JASPAR Predicted Transcription Factor Targets	1.0	null
SUP-B15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.51889
496100374_HIP_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02554
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.505438
USF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fulvestrant-5565	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18307373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11815
SNU-484	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20738
GTEX-NL3H-0011-R6a-SM-2I3G8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861751
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
pancreas	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
PMC4975902-12864_2016_2842_MOESM12_ESM.xlsx-targets_of_IRF8_in_NSCLC-COX7C_IRF8	Rummagene Transcription Factor Associations 2026	1.0	null
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.28577
BRD-K36944891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45395
GTEX-OHPN-0011-R3A-SM-2I5FC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858486
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.40484
Brain Lower Grade Glioma_LGG_TCGA-P5-A77W-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_cardiac fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862037
prochlorperazine-4439	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SIHA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20738
lobelanidine-2897	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.924762
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UTHO-0011-R1A-SM-3GIJO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845042
BRD-K34798837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30983
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
NCIH1793	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68494
RERFLCAD1	DepMap CRISPR Gene Dependency	1.0	2.63721
gallbladder_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.31303
WB-4101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76821
GSE146074_1_v_11_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_3_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
CCNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04223
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ETS1	ENCODE Transcription Factor Targets	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
piracetam-5462	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_HSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K91895574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17819
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11079006-41467_2024_48118_MOESM7_ESM.xlsx-E2F6_OE_vs_EGFP_CTR_DE-gene_E2F6	Rummagene Transcription Factor Associations 2026	1.0	null
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.67047
GSE205163,GSE205164_1_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
fulvestrant-5598	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
USF1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF2	ENCODE Transcription Factor Targets	1.0	null
troglitazone-1070	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
skeletal muscle	HPA Tissue Protein Expression Profiles	-1.0	-0.867575
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.21437
norethisterone-7414	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K14671528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67763
BRD-K18629365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27504
VZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.908819
821_BET1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.24811
GTEX-Q2AG-0011-R8A-SM-2HMK5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03065
GSE200839,GSE233826_2_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KCI-MOH1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.992716
GTEX-WL46-0011-R2A-SM-3LK6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45514
OCUG1	DepMap CRISPR Gene Dependency	1.0	2.56908
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-N7MT-0011-R10A-SM-2I3E1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09292
SNU-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.06002
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.42372
GTEX-R55E-0011-R5A-SM-2TC5N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35117
MAZ_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K01757377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09944
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
pancreas	HPA Tissue Protein Expression Profiles	1.0	1.02578
REST_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
piperacetazine-7191	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
rottlerin-825	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cefotaxime-7186	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
moroxydine-6705	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T6MN-0011-R2A-SM-32QOW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29343
GSE224599_0_v_1_tfcp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
allantoin-5471	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ATRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61437
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.4878
ifenprodil-7404	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BT549	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.08815
terbutaline-3202	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE237984_1_v_0_magi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136896
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-1.33935
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.857287
LS123	CCLE Cell Line Gene CNV Profiles	1.0	1.96591
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.847642
BRD-K96619480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46341
skin_5e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.02287
Perturb_2698_KD_EXOSC8_ERP005739	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE121319_1_v_0_gprc5a_human	RummaGEO Gene Perturbation Signatures	1.0	null
clofazimine-4682	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
chloroquine-7012	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K10775155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61677
Urogenital Abnormalities	CTD Gene-Disease Associations	1.0	1.05936
Mesolimbic dopaminergic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.636
fenbendazole-4542	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XLM4-0011-R4B-SM-4AT5C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34772
5114445-901	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13359
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07971
SMC1-22415368-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14671
H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CAL 54	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.25267
clofilium tosylate-6830	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125219,GSE125221_5_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
PKG1	Kinase Library Serine Threonine Kinome Atlas	1.0	null
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC9314667-Table_1.xlsx-Regulons-STAT1_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
stratum pyramidale of rostral CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.86251
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CORL24	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53462
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14598_KD_E2F1/E2F2/E2F3_SRP252426	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.79908
Brain Lower Grade Glioma_LGG_TCGA-R8-A73M-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_7959_KD_ZFC3H1_SRP222099	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.77098
A549_FLLL32_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169993
etamsylate-4576	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216538
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE122509,GSE122513_3_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GB-73-QS80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.44896
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
thyroid_5b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.92687
BRD-K30071505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15432
GSE203158_12_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
betulin-3513	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-398 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.058
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.15124
GTEX-T6MN-0011-R1A-SM-32QOY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20804
azacyclonol-5398	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-X261-0011-R7A-SM-4E3JJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930657
MEL270	DepMap CRISPR Gene Dependency	1.0	2.11654
Hand1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	50.8851
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_K27me3_17603471_mouseMEF	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K54099984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36632
GSE217776,GSE217829_1_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
TK10	BioGPS Cell Line Gene Expression Profiles	1.0	0.9131
MYOG	ENCODE Transcription Factor Targets	1.0	null
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S14-Table_S14_MR_resluts_of_brain_pQTL_and_cardioembolic_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
REST_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
FOSL2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2998	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.17945
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.231784
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.45935
GTEX-XUW1-0005-SM-4BOQ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10237
Vagina	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.577502
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
gramine-3999	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-94-A5I4-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN008_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0667
BRD-K45694673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12107
brain_3b	HPA Tissue Sample Gene Expression Profiles	1.0	1.3398
enlarged thymus	MGI Mouse Phenotype Associations 2023	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
KLF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	105.351
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sulfasalazine-5446	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K22870904	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4527
GTEX-S7SE-0011-R7A-SM-2XCDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75946
mycophenolic acid-4137	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PWN1-0626-SM-48TDT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95015
lateral tuberal nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.25406
GTEX-T5JC-0011-R9A-SM-32PLV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884377
ractopamine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27682
EZH2	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A513-01A-12R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K57382977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23725
GSE236504,GSE236505_0_v_1_atmin_human	RummaGEO Gene Perturbation Signatures	1.0	null
2,6-dimethylpiperidine-3806	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-6156-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30698
PMC3376834-emmm0004-0052-SD2.xlsx-NR2E3_Specific_1847-Unnamed_1_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE65617_0_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-1.22228
BRD-K03875473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11623
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
2793_EXOSC6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.84347
NCIH1648	DepMap CRISPR Gene Dependency	1.0	6.474
terconazole-4583	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
uterus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-O5YV-2026-SM-2D7VS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
zuclopenthixol-7356	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
BRD-K24422491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24954
nomifensine-7217	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE178532_2_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20J-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
sulfadimethoxine-4724	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.897095
Nerve - Tibial	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.613785
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81665173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7752
GTEX-WHSE-3126-SM-3P5ZI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906785
GLRX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35332
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.65331
felodipine-3295	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OVCAR8	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.49025
Inflammation	CTD Gene-Disease Associations	1.0	1.43946
Lung squamous cell carcinoma_LUSC_TCGA-60-2696-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF740	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	125.521
A549_Vandetanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152101
GSE157555,GSE157556_4_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE205976,GSE205978_3_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-CCRF-CEM_EV_vs_ectopic_TET2_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K72580121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10317
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
conessine-4191	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-0.867575
ACHN	BioGPS Cell Line Gene Expression Profiles	1.0	0.969047
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10374
H3K4me1_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5185-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Autism spectrum disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.116
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Episodic kinesigenic dyskinesia 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.808
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QMR6-0011-R4A-SM-32PKU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08913
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
pralidoxim	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58125
SPCS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09017
GTEX-XLM4-3126-SM-4AT6M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892167
Extrachromosomal circular DNA	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.528
BACH1_02_188	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	4.08746
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6D8-01A-31R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	90.5239
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
YAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-6.3758
RCOR1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
midbrain reticular formation, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.54317
BRD-K96660315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25451
DC-47-KV62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200653
Skin Neoplasms	CTD Gene-Disease Associations	1.0	1.0869
KDM5A	ENCODE Transcription Factor Targets	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K36063519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26394
A549_Ruxolitinib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198419
GABPA	ENCODE Transcription Factor Targets	1.0	null
Prestwick-1085-3554	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218604
PMC10760404-NIHMS1688779-supplement-Supplementary_Table_S6.xlsx-EMP_CREB_Targets-symbol_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4455	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
H4K20me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0766
RBIS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27831
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.4699
BRD-K90881556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53432
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-W5WG-1926-SM-4KKZK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07729
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.883683
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K59130962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30337
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE213588_9_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.8875
GTEX-WVLH-2926-SM-3MJG5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27402
BRD-K21412601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15417
HT1376	CCLE Cell Line Gene CNV Profiles	1.0	2.25183
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.850967
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.86923
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	112.385
BRD-K87541124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52412
LD-69-ZV56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216769
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.83974
Perturb_17364_Mut|OE_Sik3E13_SRP334442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	16.4368
GTEX-SE5C-1026-SM-4BRUG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830474
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100336_TCx_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.96228
YD15	DepMap CRISPR Gene Dependency	1.0	2.00422
16207381-Table1Sb	GeneSigDB Published Gene Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.57161
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7862-01A-21R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S4Z8-2026-SM-3K2A9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
REST_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16141
lobeline-2763	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K77733130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32499
HCC1482	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.54556
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
butyl hydroxybenzoate-4647	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FF-28-ES17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265233
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05347
BRD-K02118124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25596
H3K27me3_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-8460-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreatic_Islets	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.0108
TMEM181	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00727
posterior hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.859308
H3K4me1_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10299
COV318	CCLE Cell Line Gene Expression Profiles	1.0	1.40986
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HC-01-FD24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28873
REST_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13615_KD_Sfpq_SRP045368	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.63143
BRD-K36042673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22779
praziquantel-7228	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
D-263MG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_MCF-7_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIHA	CCLE Cell Line Gene CNV Profiles	-1.0	-1.66432
Monogenic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.096
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2457
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CB-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRPF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55648
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16077
Perturb_8520_KO_Kctd13_ERP112326	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.10952
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.52377
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A634-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDVN-2426-SM-2S1Q4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
haloperidol-1082	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15552
Delamanid_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0263651
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.70213
outer portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07395
thioperamide-4675	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSE-0011-R8A-SM-3P5Z1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20443
MOLT-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sulfachlorpyridazine-6046	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CF-24-KQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.400135
496100338_HIP_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.8074
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
minaprine-1468	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A459-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K18887540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30684
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GlobusPallidus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.21364
BRD-K57228212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05891
GTEX-XLM4-3026-SM-4AT6L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.992686
GTEX-TKQ2-0826-SM-33HB6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847643
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04302
cytisine-6217	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HDAC2_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
microphthalmia	MGI Mouse Phenotype Associations 2023	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-5423-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K63487554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00919
CRCGN017_MCF10A.TP53.M_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25622
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A871-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H4K20me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QVJO-0011-R1A-SM-2S1QI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04604
Prestwick-675-6042	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
abnormal tooth morphology	IMPC Knockout Mouse Phenotypes	1.0	null
mimosine-5302	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LY-294002-6935	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-N7MS-0011-R4a-SM-2HMKW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55141
BRD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1679
H3K9ac_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M5-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2944-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Memory Disorders	CTD Gene-Disease Associations	1.0	1.46935
OVCAR-5	GDSC Cell Line Gene Expression Profiles	1.0	1.49179
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-NJ-A55O-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.985003
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4017
GTEX-UTHO-0011-R5A-SM-3GIJD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851155
NFIC	ENCODE Transcription Factor Targets	1.0	null
GSE233679_6_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
diprophylline-5482	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE129293_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU-407	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K80196706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04659
GSE224004,GSE224005_0_v_8_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_TMP195_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126731
AASDHPPT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17481
Perturb_7923_KD_EXOSC3_SRP222099	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.9016
CTCF_GM20000_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12869_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RNOR-0011-R7A-SM-2TF4V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60133
GTEX-UTHO-0011-R11A-SM-3GIJE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838682
A549_SRT3025 HCl_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152924
BRD-K04495110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72848
central gray substance of midbrain, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.865117
ondansetron-6270	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4858-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
diclazuril	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.28796
valproic acid-994	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RVPV-0011-R3A-SM-2TF63	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00971
CTCF_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SB-203580-6894	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
valproic acid-6999	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.979662
GTEX-WZTO-0011-R7B-SM-4E3IS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34033
Minor Salivary Gland	GTEx Tissue Gene Expression Profiles 2023	1.0	1.84629
Fetal Death	CTD Gene-Disease Associations	1.0	1.31119
GSE147876,GSE147877_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Dental caries	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.946
GTEX-WL46-0011-R9A-SM-3MJFP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16188
BRD-K66870022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00616
GSE203158_0_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
A549_G007-LK_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136497
GSE165636_0_v_4_tofacitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.4828
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.70978
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_6028_KD_KHDRBS1_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.71357
GTEX-T6MN-0011-R7A-SM-32QP5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14701
BRD-K09071517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05178
CCRF-SB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.33923
brain	GTEx Tissue Gene Expression Profiles	1.0	1.52853
thyroid gland	HPA Tissue Protein Expression Profiles	-1.0	-0.867575
BRD-K37386363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06599
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Spleen	GTEx Tissue Gene Expression Profiles 2023	1.0	1.99649
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K45495792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51499
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVJO-0011-R2A-SM-2S1QK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12878
haloperidol-6163	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
icSARA deltaORF6_30Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.65548
GSE152441,GSE152442_6_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
maprotiline-3236	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventromedial hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03285
GSE159049_1_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	1.0	null
hesperidin-5313	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE78199_2_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S33H-2426-SM-2XCB2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
mepenzolate bromide-3829	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K01951210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56867
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.881081
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193993_1_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
G112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.994016
colorectum	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.65083
GSE147876,GSE147877_4_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KLF10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	184.922
CTCF_A549_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0011-R2A-SM-32PLZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69289
GTEX-X585-3026-SM-46MWF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0818
terguride-5400	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE193258,GSE193259_9_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HA-E2F1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
H3K79me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KAT2B_02_184	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.62149
GSE205976,GSE205978_1_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_7931_KD_ZFC3H1_SRP222099	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.71963
GSE220629_0_v_1_foxp3_human	RummaGEO Gene Perturbation Signatures	1.0	null
cellular protein modification process	GO Biological Process Annotations 2015	1.0	null
Pentagastrin_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0267873
TCF12	ENCODE Transcription Factor Targets	1.0	null
GSE202434,GSE202438_12_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_CH12.LX_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ECD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07463
SB-94-ZA83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256571
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.41685
20460542-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
GSE42805,GSE42811_2_v_3_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
tracazolate-7339	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZBTB7A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB7A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE146982_3_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K27335290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67189
Lung squamous cell carcinoma_LUSC_TCGA-56-8309-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T5JC-0011-R10A-SM-32PM2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10069
nipecotic acid-7296	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06647
H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S12-Table_S12_MR_resluts_of_brain_pQTL_and_any_ischemic_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
pituitary	GTEx Tissue Gene Expression Profiles	1.0	1.26355
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOP-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.935317
GSE178714_5_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.2336
GSE193258,GSE193259_5_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH2081	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37777
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15002
GTEX-N7MS-2526-SM-2D7W3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17914
mebeverine-6795	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPS34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54552
USF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08052
GSE191015_0_v_2_gsdmb_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_HCT116_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K32706281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11643
496100369_PCx_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.18762
BRD-K70198986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33008
BRD-K81881801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12916
PHF8-20622854-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TEAD4_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0011-R1A-SM-2XCDE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875305
Intercalated nucleus of amygdala	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.995419
cisapride-5305	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K57556489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14554
POLR2A	ENCODE Transcription Factor Targets	1.0	null
CHERP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-5.07733
Delamanid_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.028495
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K56343202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09232
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.52111
EW-12	GDSC Cell Line Gene Expression Profiles	-1.0	-1.84954
GSE193258,GSE193259_2_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
chlortetracycline-6761	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Joubert syndrome 13	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.341
novobiocin-4392	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SMARCB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22023
VZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.39855
NANOG	ENCODE Transcription Factor Targets	1.0	null
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
solasodine-6025	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
primary auditory cortex (core)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.976342
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A7T6-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K49698948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09847
tretinoin-6243	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRCA1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18725
1716_CNOT1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.11635
postcentral gyrus, left, bank of the posterior central sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.839182
CTCF_HCT116_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
BRD-K78856515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47799
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
ZNF263	ENCODE Transcription Factor Targets	1.0	null
Edema	CTD Gene-Disease Associations	1.0	1.35676
BRD-K07438289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22945
PMC2883591-pgen.1000979.s003.xls-NRSF_GENELISTS_WitOut_GeneSig_g-Unnamed_1_REST	Rummagene Transcription Factor Associations 2026	1.0	null
estradiol-988	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K15202679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.43669
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_01_136	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.6603
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.931725
Prostate adenocarcinoma_PRAD_TCGA-XQ-A8TA-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE211262,GSE211263_3_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8033524-EMMM-13-e13162-s004.xlsx-d_GREAT_on_NFIB_bound-genes_HF-Unnamed_0_NFIB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146074_6_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
fenbufen-3721	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S11-Table_S11_MR_resluts_of_brain_pQTL_and_any_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
NOL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19088
Chromosomal deletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-73-4668-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11235
cyclopentolate-6214	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28928
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30227
GSE195568_6_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BTNL8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00458239
CHP-134	GDSC Cell Line Gene Expression Profiles	1.0	1.91988
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12721900-jci-136-187998-s161.xlsx-Flag-ETS1_vs_vector-Gene_ETS1	Rummagene Transcription Factor Associations 2026	1.0	null
PC14	CCLE Cell Line Gene CNV Profiles	1.0	1.44196
BRD-K12710356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28697
GSE233049_2_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
REST_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDAMB361	CCLE Cell Line Gene CNV Profiles	1.0	1.35617
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A74K-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.57318
GTEX-XQ3S-0626-SM-4BOOB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.878497
GTEX-TKQ2-1226-SM-4DXSV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.831953
REST_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
OLFM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13959
GTEX-Q2AG-2826-SM-2HMJQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12891
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K22475995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67759
Mouth disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.946
fluphenazine-7234	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16216
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.67159
6740_PREB_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.68663
NAT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08325
ACO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17331
PMC8143797-elife-62857-fig3-data2.xlsx-DEgenes_SW872_CAMTA1_vs_subEV-Gene_CAMTA1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
GTEX-U3ZM-1226-SM-3DB9G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02596
CRCGN008_HEPG2_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8774
amoxicillin-6285	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Tooth disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.946
GTEX-Q2AG-2926-SM-2HMJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44249
BRD-K13888422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0249
CREB	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE214382,GSE214383_1_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
bergenin-7224	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PSDG-0426-SM-2S1OF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
UBE2M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0177
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K71472853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2069
suramin sodium-7496	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ethotoin-3809	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.65278
epiandrosterone-4626	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.4236
NOZ	DepMap CRISPR Gene Dependency	1.0	5.14703
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9038526-mmc1.xlsx-postCOVID_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RVPV-0011-R11A-SM-2TF6F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0879
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pargyline-7016	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.955007
CRCGN017_MCF10A.TP53.M_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19275
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17622
HG3	DepMap CRISPR Gene Dependency	1.0	3.60857
BRD-K17574409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11746
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anemia	CTD Gene-Disease Associations	1.0	1.16733
ILKAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0045
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
Cardiovascular Abnormalities	CTD Gene-Disease Associations	1.0	1.38946
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
H3K14ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hydralazine-3724	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WEY5-0426-SM-3GIKT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
orbital frontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08888
CTCF_medulloblastoma_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20626
BRD-K06935782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29902
diphenylpyraline-6061	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CCDC51	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5592
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.945387
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB7A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H82	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.860825
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270443
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.38473
CTCF_LNCaP clone FGC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Small Intestine - Terminal Ileum	GTEx Tissue Gene Expression Profiles 2023	1.0	2.27747
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.953231
BRD-K30566330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9431
BRD-K10893370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06184
PNPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67895
central gray of the pons, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.907656
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06454
BRD-K17840858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89882
MKN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15702
sitosterol-7332	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-NPJ7-0011-R2a-SM-2I3GF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.042
gabexate-4804	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.42026
orbital frontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.89015
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
seminal vesicle	HPA Tissue Protein Expression Profiles	-1.0	-0.867575
hsa-miR-766	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
diethylstilbestrol-3812	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.45774
5255229-949	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
REST_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEx Uterus 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-5.79146
Perturb_7758_KD_MTREX_SRP337423	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.94094
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.13029
BRD-K25236390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41436
difenidol-7406	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
sirolimus_homo sapiens_gpl2895_gse16944	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ethotoin-6052	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Phelan-McDermid syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
RPS13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16154
H3K4me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE224556,GSE224557_6_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Weight Loss	CTD Gene-Disease Associations	1.0	1.36961
CTCF_MEL cell line_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K46124507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00991
BRD-K02230174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33211
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HDAC6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCNT2	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HT-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-A5EL-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.59578
acetylsalicylic acid-984	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.623262
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KYSE-520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.95087
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07162
Perturb_4073_KO_Bcl11b_SRP260102	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.51963
GSE153836_11_v_2_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7SE-0011-R6A-SM-2XCD9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19364
GSE224096_1_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
BRD-K03057797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0773
decreased circulating alkaline phosphatase level	IMPC Knockout Mouse Phenotypes	1.0	null
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MXI1	ENCODE Transcription Factor Targets	1.0	null
AC-36-TL21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247921
sw837	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.532
GTEX-WHSE-0011-R2A-SM-3P5ZL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32004
GTEX-T8EM-1626-SM-3DB7K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
quinidine-5793	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Q-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K22633587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55934
BRD-K64770897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43297
Cell Transformation, Neoplastic	CTD Gene-Disease Associations	1.0	1.22979
ARCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02105
H2BK120ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K33283629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24647
CBFA2T2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54179
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.994016
Cepharanthine_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0176815
CA1 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.138
GSE125219,GSE125221_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PK1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.73279
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T2IS-2926-SM-32QPO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941488
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.63357
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QVJO-1426-SM-2S1QY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.924066
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE234514,GSE234516_2_v_0_mitf_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19298
BRD-K31503053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1753
PMC11908325-media-2.xlsx-Table10_MR-Unnamed_6_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
adiphenine-7037	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XLM4-0011-R8A-SM-4AT44	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1876
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5692-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K98086832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35614
BRD-K49031847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63528
Body fat distribution (arm fat ratio)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.522185
BRD-K72869385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05554
GTEX-NFK9-0626-SM-2HMIV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07418
RAD21_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03554945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09819
Perturb_5717_KO_Fyn_SRP398323	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.3901
chlormezanone-4636	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_4714_KO_Hnrnpu/Trp53_SRP331236	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
BRD-K53953065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00125
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Artery - Coronary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.585518
Lung squamous cell carcinoma_LUSC_TCGA-43-5670-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE249098_1_v_0_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.01016
H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
C17orf80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06439
GTEX-T5JC-0011-R5A-SM-32PLK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40274
H3K4me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
abamectin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35659
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.29927
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.30034
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE180185_4_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TE-6	GDSC Cell Line Gene Expression Profiles	-1.0	-1.84302
GSE146982_3_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A4ZP-01A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE172016_2_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CALU6	DepMap CRISPR Gene Dependency	1.0	2.98093
SK-MEL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.888555
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C-33 A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.966424
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E8-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.527
GSE203485_1_v_0_zdhhc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VCAP	CCLE Cell Line Gene CNV Profiles	-1.0	-1.76572
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
SKMM2	CCLE Cell Line Gene CNV Profiles	1.0	1.48066
intestine	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Developmental coordination disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.216
GSE157383_3_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE208350_0_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21716
monensin-3704	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
alpha-ergocryptine-4552	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NCIH441	DepMap CRISPR Gene Dependency	1.0	2.66333
fulvestrant-6867	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KMS34	DepMap CRISPR Gene Dependency	1.0	4.21675
mebeverine-3193	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Rectum adenocarcinoma_READ_TCGA-DY-A1DD-01A-21R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
flavoxate-6326	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K40735917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4076
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_foreskin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
(-)-MK-801-6657	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WL46-2826-SM-3LK81	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34836
A549_Fedratinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190531
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125014_6_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
diethylstilbestrol-4547	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OC-10-FB51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218567
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4710-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LNCAP	BioGPS Cell Line Gene Expression Profiles	1.0	2.26466
SIN3A_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K71775851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23394
GTEX-V955-0726-SM-3GAFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05784
SK-MEL cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.695
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC3153	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.791009
BRD-K36090848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05469
GTEX-X4EP-0011-R2B-SM-3P625	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87616
GTEX-X4EP-3226-SM-3P5YR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901155
BRD-K95033255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23767
GTEX-QVJO-0011-R8A-SM-447C7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0643
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE214931_2_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
REST_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QMR6-0011-R1A-SM-32PKW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37339
GTEX-N7MS-0011-R1a-SM-2HMJG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66832
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K98639224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19489
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F1	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K53662389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71689
PMC8143797-elife-62857-fig4-data2.xlsx-CAMTA1_ChIP_RNAseq_merged-ENSEMBL_CAMTA1	Rummagene Transcription Factor Associations 2026	1.0	null
EJM	CCLE Cell Line Gene CNV Profiles	1.0	1.63585
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13199
MCC13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC11956947-media-4.xlsx-C_GSEA_gene_sets-TGAYRTCA_ATF3_Q6_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
H4K20me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.80086
RFX5	ENCODE Transcription Factor Targets	1.0	null
blood	GTEx Tissue Gene Expression Profiles	-1.0	-1.00963
CI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
meptazinol-7326	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
REST_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
calcium folinate-3703	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K75130046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.68029
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VX-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOPS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.81
BRD-K30284601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0831
PMC6145927-41467_2018_5729_MOESM6_ESM.xlsx-TF_Activity_Genesets-SNAIL_UP_SNAI1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K77845452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3749
P31-FUJ	COSMIC Cell Line Gene Mutation Profiles	1.0	null
thioguanosine-6643	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.84865
resveratrol-841	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.91999
GABPA_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3174
GTEX-NL4W-0011-R5a-SM-2I3GD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843704
EP300_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.24893
PMC10794847-mmc2.xlsx-PBRM1_KD_down-Table_S1_Differentially_expressed_genes_with_PBRM1_knockdown_in_the_progenitor_state_Related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.835194
quipazine-7240	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0011-R4A-SM-3NMC7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31046
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WVLH-0011-R8A-SM-3MJFC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852229
GTEX-X4XX-0011-R5A-SM-46MWN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07558
stomach	HPA Tissue Protein Expression Profiles	1.0	1.02578
Pancreas	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.894935
abnormal thymus morphology	MGI Mouse Phenotype Associations 2023	1.0	null
H3K79me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.830994
GSE150134_1_v_0_scn5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
florfenicol-5300	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE161064,GSE161065_0_v_1_kdm5b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K02959126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90374
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
proadifen-7165	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC4773428-ncomms10751-s4.xlsx-S_Table_3-Supplementary_Data_3_497_common_genes_differentially_expressed_in_ER_breast_tumors_with_RUNX1_mutations_in_both_TCGA_and_Ellis_et_al_cohorts_FC_1_3_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18454
CTCF_fibroblast of lung_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100347_PCx_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.63805
GSE205687_1_v_0_mta1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15552
parabigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.849241
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.754
GB2	DepMap CRISPR Gene Dependency	1.0	2.14446
SPI1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE132369,GSE132371_3_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
haloperidol-4678	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
clobetasol-6835	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UTHO-0011-R2A-SM-3GIKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92639
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.29992
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
ethambutol-4001	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
methylphenidate_mus musculus_gpl11180_gse33619	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IHH-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE68155_1_v_0_gpr3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE138863_3_v_0_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
anterior amygdaloid area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.42222
GTEX-UTHO-0726-SM-3GAEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vagina	HPA Tissue Protein Expression Profiles	-1.0	-0.867575
MAX_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL-120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34307
PMC4595011-pgen.1005555.s001.xlsx-BPTF_UP-regulated-Ensembl_gene_id_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
locus ceruleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02085
dorsal motor nucleus of the vagus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03608
GSE139016_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CORL311	DepMap CRISPR Gene Dependency	1.0	2.14796
midbrain raphe nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.877984
GTEX-WWYW-0011-R11A-SM-3NB38	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01
PMC8635809-Table_2.xls-LPS-downregulated-Unnamed_4_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
cinoxacin-6257	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Oligospermia	CTD Gene-Disease Associations	1.0	1.07376
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-MN-A4N5-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Proteinuria	CTD Gene-Disease Associations	1.0	1.32251
5462_NAPA_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0221
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05805
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
SUPT1	DepMap CRISPR Gene Dependency	1.0	3.73396
PMC9248879-supp_gr.275831.121_Supplemental_Table_S2.xlsx-TP53-dependent_proteins-GeneName_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
CP-944629-7497	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-661	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
large intestine	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE144453,GSE144454_1_v_0_tfdp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
mRNA_TCEA3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GTEX-X4XX-0011-R1B-SM-3P622	GTEx Tissue Sample Gene Expression Profiles	1.0	0.928861
GTEX-UTHO-2926-SM-3P5Z9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10689
GSE130956_0_v_3_icaritin_human	RummaGEO Drug Perturbation Signatures	1.0	null
UBTF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T8EM-1326-SM-3DB7G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08104
H3K4me1_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Heart - Atrial Appendage	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.586151
GSE142684_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0011-R2A-SM-2XCDC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865515
GSE119498_0_v_10_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Stomach Smooth Muscle	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.976598
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7432-11A-01R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K37387086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32556
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3426-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE234340_12_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195568_6_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4595011-pgen.1005555.s003.xlsx-MITF_UP-regulated-Gene_name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-0011-R1A-SM-3NM8J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19643
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
COLO 678	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.36843
BRD-K03935681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20805
PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-gene_name_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202434,GSE202438_7_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
stomach_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.101
496100549_FWM_no dementia_TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.15442
Spinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
pontobulbar body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.44515
BRD-K45200389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27824
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K27888332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06977
sirolimus-5932	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-SNOS-1526-SM-32PLW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.906854
HDMYZ	DepMap CRISPR Gene Dependency	1.0	2.04027
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Spondyloepimetaphyseal dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.296
PMC7594423-12915_2020_895_MOESM13_ESM.xlsx-Table_S6D-Table_S6D_-_Differentially_Expressed_genes_shared_between_BRCA_TRIM25_amp_and_STAD_CIC_Del_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AG-0011-R6A-SM-2HML7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41127
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148252_7_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868065
BRD-K68463857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40135
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.51405
CEBPD	ENCODE Transcription Factor Targets	1.0	null
BRD-K60758969	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73731
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.31006
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0902
GTEX-P44H-0011-R5A-SM-2XCEX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826784
GTEX-OXRL-1826-SM-2YUMV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
Perturb_5966_KD_SUMO2_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.70733
FU97	CCLE Cell Line Gene Expression Profiles	1.0	1.35759
BRD-K76539747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1875
cefuroxime-6088	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lymphnode_4a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.853759
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC12178829-mmc4.xlsx-Sheet_4-MEG3-KD_Up-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
prostate	HPA Tissue Protein Expression Profiles	1.0	1.02578
BRD-K23204014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3486
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A6C6-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K06529600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54204
Developmental disorder of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.116
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.759
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K51196703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56655
VZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.980971
GSE205163,GSE205164_9_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MOCS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08075
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
0317956-0000-4334	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
minocycline-7436	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE233679_14_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Autosomal genetic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.096
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K02473319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29383
GSE178714_5_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128232,GSE128233_1_v_0_phf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.32386
SUZ12	ENCODE Transcription Factor Targets	1.0	null
BRD-K24494475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03897
abnormal eye morphology	IMPC Knockout Mouse Phenotypes	1.0	null
abnormal tail morphology	MGI Mouse Phenotype Associations 2023	1.0	null
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158715_3_v_0_cyp1b1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CML-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.84405
nadide-7227	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XQ8I-0626-SM-4BOPT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
BRD-K38111331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24057
GSE235587_2_v_1_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-125b	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15552
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ASPC1	CCLE Cell Line Gene Expression Profiles	1.0	1.71051
WDR33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06271
isometheptene-5082	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SET-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.957897
betonicine-6063	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GABPA_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nilutamide-6763	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC10901781-41467_2024_46134_MOESM12_ESM.xlsx-Supplementary_Data_9-Supplementary_Data_09_Differential_expressed_genes_in_RUNX1-mutated_AML_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211425_1_v_0_mettl3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cepharanthine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0180612
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19931
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.842367
HCC1833	CCLE Cell Line Gene Expression Profiles	1.0	1.49484
sulfaguanidine-1495	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE162739_7_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
body of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08683
HS 766T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.890269
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ganciclovir-5389	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_322_KD_USP39_SRP279798	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
USF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Infancy electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
SIN3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KA-29-AB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206304
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.08128
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QMR6-0011-R7A-SM-32PKL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835822
piperacetazine-5834	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K60030763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35255
GSE228106_3_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE239688_2_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ERI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16323
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
RPE1SS77	DepMap CRISPR Gene Dependency	1.0	2.27616
Lung adenocarcinoma_LUAD_TCGA-44-7659-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05231
inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.919613
DROSHA_02_01	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61138
CTCF_fibroblast of skin of abdomen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH650	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33269
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IHH4	DepMap CRISPR Gene Dependency	1.0	2.10376
TemporalLobe	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.22815
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_17316_KO_Tardbp_SRP321767	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.03435
CTCF_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R9A-SM-2HMJ6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18755
PMC11376028-13578_2024_1300_MOESM1_ESM.xlsx-CCF_2nd_round-SYMBOL_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
Tfcp2l1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.4905
GSE218060_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07911
REST_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210476_11_v_4_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X4EO-0526-SM-3P5Z3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883748
GSE80098,GSE80366_0_v_6_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-58-8386-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K11095218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.51552
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147876,GSE147877_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gallbladder_5b	HPA Tissue Sample Gene Expression Profiles	1.0	1.12098
Pancreatic adenocarcinoma_PAAD_TCGA-OE-A75W-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A766-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE152441,GSE152442_0_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-ensembl_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2941-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220597
CTCF_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE62843,GSE64371_4_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QCQG-1926-SM-2S1PI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
GTEX-WHSE-0011-R1A-SM-3P5ZK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42096
USF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hypertension	CTD Gene-Disease Associations	1.0	1.18293
Perturb_16856_KO_Hnrnph1_SRP068520	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.60769
EA-40-KQ08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285735
CTCF_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hyperplasia	CTD Gene-Disease Associations	1.0	1.38298
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.48414
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CRCGN012_HEPG2_24H:E06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27759
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Vasculature-epithelial cell	Tabula Sapiens Gene-Cell Associations	1.0	0.370794
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
body of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01887
Hyperglycemia	CTD Gene-Disease Associations	1.0	1.06881
USF1	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3346-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE223241_2_v_0_cdkn2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X4XX-0011-R3B-SM-46MWK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.885224
Perturb_9415_KD_Mecom_SRP356893	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.85348
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KYM1	DepMap CRISPR Gene Dependency	1.0	2.23405
CTCF_MCF-7_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X261-0011-R11A-SM-4E3JY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15338
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE87615_2_v_3_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
Perturb_5926_KD_LOXL2_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.3823
GSE205163,GSE205164_5_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-5644-01A-21R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148252_1_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
Brain Lower Grade Glioma_LGG_TCGA-CS-6669-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.909094
BRD-K99331577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10513
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MTOR_UP.N4.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
21205295-TableS1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-S7SE-0011-R10A-SM-2XCDF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.928307
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5107-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Fasudil_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130092
Acute Myeloid Leukemia_LAML_TCGA-AB-3002-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE114284_4_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_x_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
roxarsone-5470	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-UJMC-1826-SM-3GADT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0865
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.386954
GTEX-TSE9-0011-R4A-SM-3DB7H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865632
sirolimus-1667	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
josamycin-1534	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
tetrandrine-6082	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WEY5-2126-SM-3GILK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
Bipolar disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K45904718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0439
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0011-R11A-SM-4E3K9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25852
GTEX-WHSB-1826-SM-3TW8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.968317
central part of CEl	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13951
A549_SRT3025 HCl_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150188
alvespimycin-6933	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K36997940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8694
Vitamin K4_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0145565
GTEX-RVPU-0011-R9A-SM-3NM8E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21161
GTEX-R55E-0006-SM-2TC5G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941309
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T5JC-0011-R11A-SM-32PMB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10008
PMC9314667-Table_1.xlsx-Regulons-ETV4_ETV4	Rummagene Transcription Factor Associations 2026	1.0	null
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47891
enilconazole-5538	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XMD1-0011-R3B-SM-4AT5R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982209
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7072-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K93927229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25585
NFYA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-0011-R5A-SM-2TF6U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16666
REST	ENCODE Transcription Factor Targets	1.0	null
YY1-22570637-MALME-3M-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
LNZTA3WT4	DepMap CRISPR Gene Dependency	1.0	2.11779
GSE150134_1_v_0_fluorouracil_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.269
Acute Myeloid Leukemia_LAML_TCGA-AB-2877-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.60722
REST_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Larval brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.706
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
dorzolamide-6259	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125219,GSE125221_4_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8506-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC364	CCLE Cell Line Gene CNV Profiles	-1.0	-1.98793
BRD-K03287885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36491
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.61878
GSE157894_1_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K49328983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55121
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.828251
PANC0327	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48305
CRCGN017_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.29774
cetuximab_homo sapiens_gpl570_gse21483	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NOP53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14122
GTEX-S32W-2326-SM-2XCAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
estradiol-5318	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
levcycloserine-4524	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K67082570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09523
BRD-K74948793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04343
famotidine-1529	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE181513_2_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233049_1_v_3_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K93774122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31447
BRD-K24950073	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14032
dorsolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.840757
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.71183
pioglitazone-5930	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_10006_KD_SF3B1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.82274
IL2_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
GSE256181_1_v_0_etv2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5358377-pnas.1615015114.sd02.xlsx-Sheet1-genes_with_VDR_peaks_with_and_without_D3_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
CCDC71L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76036
GSE233679_14_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNU-C2B	COSMIC Cell Line Gene Mutation Profiles	1.0	null
tobramycin-4162	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
tocainide-4256	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-T5JC-0011-R4A-SM-32PLT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35657
moracizine-6000	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K08753635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32627
guaifenesin-4549	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
sirolimus-921	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WI-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SAP30	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.64768
HD-26-KX74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21367
Perturb_16947_OE_Mir181a1_SRP359086	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.2039
felbinac-4639	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE95685_2_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE239844_7_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WFJO-0826-SM-4LVM5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
Rectum adenocarcinoma_READ_TCGA-DY-A1DF-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05074
GTEX-QVUS-0011-R4A-SM-3GAE7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827492
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pinacidil-7437	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-N7MT-0011-R8a-SM-2I5GU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04725
CTCF_cardiac muscle cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-2526-SM-2XCDL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935217
GTEX-R53T-2026-SM-3GIJF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.87232
PMC11821528-41588_2024_2050_MOESM12_ESM.xlsx-MR-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
IL21_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.945587
GTEX-T6MN-0011-R9A-SM-32QOZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16053
GSE76425_0_v_5_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.803888
noscapine-2745	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-POMQ-2126-SM-2S1OJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.99334
betazole-1690	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MT-ATP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45146
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE152441,GSE152442_0_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WOFM-1726-SM-3MJFA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.906664
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Spondyloepimetaphyseal dysplasia with joint laxity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.858
valproic acid-6941	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
6-bromoindirubin-3'-oxime-7044	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K36298208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29379
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.929994
CTCF_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K68458302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36664
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVJO-0011-R6A-SM-2S1QN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933916
5825_NSF_ENST00000398238.4	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04126
GTEX-SJXC-0726-SM-2XCFJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
CTCF_epithelial cell of esophagus_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Pirarubicin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160044
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.65322
GSE128730_7_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210885_2_v_4_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.55885
PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-Genes_with_ATF3_combined_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
MDAMB453	CCLE Cell Line Gene CNV Profiles	1.0	1.52893
Glucose Intolerance	CTD Gene-Disease Associations	1.0	1.25899
Sarcoma_SARC_TCGA-Z4-A9VC-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_02_192	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.0
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0558
FE-64-KC49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.468721
CTCF_fibroblast of skin of abdomen_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-XUJ4-2626-SM-4BOQ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.966662
Arginine/Asparagine/Proline hydroxylase	InterPro Predicted Protein Domain Annotations	1.0	null
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G142	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
diphenhydramine-6020	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM28	ENCODE Transcription Factor Targets	1.0	null
CTCF_fibroblast of pulmonary artery_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-6647-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2126	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-11A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_5235_KO_Ncor2_SRP222273	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.45783
corbadrine-7208	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-6883-01A-31R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
facial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.47925
CTCF_keratinocyte_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMC3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
amodiaquine-6224	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KIF13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27763
acacetin-4324	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prestwick-1082-3530	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30383
latamoxef-5609	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE181003_3_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A3PK-01A-21R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE234289_5_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864243
GTEX-X4XX-0626-SM-3NMC1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09669
Muscle - Skeletal	GTEx Tissue Gene Expression Profiles 2023	1.0	1.84714
CTCF_HEK293_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UTHO-0011-R4A-SM-3GIJP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18451
MDAMB415	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.823255
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.49655
Right_Atrium	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.35007
496100359_PCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.90816
GSE180185_4_v_10_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THAP1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PATZ1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	252.279
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UPJH-0526-SM-4IHK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934771
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZNF148	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	134.198
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07552
BRD-K07460436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1778
GSE217982,GSE217983_2_v_3_hgfac_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203485_1_v_0_sunitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100366_TCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.49094
GSE216352,GSE216354_1_v_0_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CLDN15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63312
REST_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-0011-R8A-SM-3NB3S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839008
GSE111660_4_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HMGN3	ENCODE Transcription Factor Targets	1.0	null
BRD-K30797133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3966
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cefmetazole-7222	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.95087
suramin sodium-7524	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ATF3_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7579-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
paracentral lobule, anterior part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.64531
GSE211128_4_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147876,GSE147877_4_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Schizophrenia 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.55
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987176
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
RAD21_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K55896279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22466
GSE152441,GSE152442_6_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TEAD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Learning Disorders	CTD Gene-Disease Associations	1.0	1.67159
C20orf96	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81451
GSE210101,GSE210114_2_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3612
piretanide-3567	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
asiaticoside-3504	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K43628610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15301
Perturb_8686_KO_Dnmt1_SRP252762	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.32036
HT144SKINFV1	DepMap CRISPR Gene Dependency	1.0	2.06271
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_12589_KO_Eed_SRP379883	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.89822
rotenone-5948	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.99018
daunorubicin-7507	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-TSE9-2926-SM-3DB77	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826932
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GSE113734_1_v_2_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MFE-319	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_fibroblast of lung_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of mammary gland_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U4B1-1626-SM-3DB8N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02152
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5456-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K05096562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71823
fluvastatin-5290	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PROKR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09798
PMC3435504-msb201237-s2.xls-Supp_Table_4b-SP1_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
bicuculline-4574	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5131
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
profenamine-5296	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CREB1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE128730_3_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
clorgiline-5005	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN014_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3225
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34056
GSE178714_5_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2528
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K19389825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14791
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K95385525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20489
H3K27me3_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT1	ENCODE Transcription Factor Targets	1.0	null
amphotericin B-5404	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRTC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42581
GSE135350_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
desoxycortone-5357	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PBX3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6563
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
paclitaxel_homo sapiens_gpl570_gse39042	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ceftazidime-5473	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A3R3-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE236486_1_v_0_arnt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-V955-2426-SM-3GAEF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25643
GSE122067_2_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
thioridazine-5916	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dioxygenase activity	GO Molecular Function Annotations 2015	1.0	null
VZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.914476
CRCGN016_MCF10A.WT.HP_24H:E18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09971
A549_TGX-221_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147019
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3319-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-RQ-A68N-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-0011-R8A-SM-3DB7R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961764
BRD-K34931072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76117
single-organism process	GO Biological Process Annotations 2015	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JN-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
solanine-4166	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
QA-34-PH05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205772
5149715-890	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
REH	COSMIC Cell Line Gene Mutation Profiles	1.0	null
nifuroxazide-4835	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DNM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1748
CTCF_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870671
PMC9013128-NIHMS1795992-supplement-4.xlsx-SKmel147_ARID2_KO_Upregulated-Gene_name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
imipenem-5997	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DiGeorge syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.127
PMC7617064-EMS151900-supplement-Extended_Data_Figure_5_Source_Data.xlsx-CLC_D9_DEG-Logfold_change_threshold_1_0_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
MNT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00430028
riluzole-2295	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S7SE-0726-SM-2XCD7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
BRD-K82392710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06643
Autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.708
USF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-ATF3_TGACGTCA_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE144231_2_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160001,GSE160670_3_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ginkgolide A-3260	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H3-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K95922469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3554
SNU-484	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.947964
TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4622
KMS-11	COSMIC Cell Line Gene Mutation Profiles	1.0	null
propafenone-6336	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K9ac_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cisplatin_homo sapiens_gpl570_gds3910	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WHSE-0011-R7A-SM-3P5YZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52694
BRD-K67036882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09744
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU5	CCLE Cell Line Gene Expression Profiles	1.0	2.26247
increased circulating creatinine level	IMPC Knockout Mouse Phenotypes	1.0	null
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
RPL24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26426
CTCFL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.2962
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.1122
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951897
POLR2AphosphoS2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSE-1126-SM-3NMBU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11386
SYK_KD_GDS3609_440_human_MCF10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
JHU-029	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XLM4-0011-R7A-SM-4AT5L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37914
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K03147246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50971
BRD-K66941670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41523
SU-DHL-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.89173
SP1	JASPAR Predicted Transcription Factor Targets	1.0	null
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.143
GSE148252_1_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K54212583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10134
PMC8384902-mmc2.xlsx-4_NEUROD1_high_subtype-Gene_Symbol_NEUROD1	Rummagene Transcription Factor Associations 2026	1.0	null
estrone-6647	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S13-Table_S13_MR_resluts_of_brain_pQTL_and_large-artery_atherosclerotic_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
dorsomedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.925602
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.08216
DND-41	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung Neoplasms	CTD Gene-Disease Associations	1.0	1.37987
Perturb_8028_KO_IRTKS_SRP310479	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
CRCGN012_HEPG2_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24214
CTCF_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDAMB361	DepMap CRISPR Gene Dependency	1.0	3.1259
Syndrome	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.096
NFYA	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
GSE135514_8_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10111863-supp_gad.350269.122_Supplemental_Paun350269_FileS3.xlsx-A_ASCL1-regulated_DGE-geneID_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K63504496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48884
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETV2-25802403-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A7UZ-01A-12R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K96925976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25319
GSE113734_3_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7546
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836664
HCC2218	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.754488
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.93248
BRD-K57502201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08895
Nervous System Malformations	CTD Gene-Disease Associations	1.0	1.16467
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266129
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0756
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.48778
midecamycin-1526	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
3583_GTF3A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.50672
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01769
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-X4XX-2926-SM-3NMB1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886994
Acute Myeloid Leukemia_LAML_TCGA-AB-2879-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15552
GSE125014_6_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EMC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19226
H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NANOG_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
stratum pyramidale of caudal CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.84877
MED15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30595
BRD-K86953192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76655
GTEX-PWOO-2326-SM-2S1PQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
aconitine-6797	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.958468
BRD-K13754152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02337
BRCA1	ENCODE Transcription Factor Targets	1.0	null
NCIH524	CCLE Cell Line Gene Expression Profiles	1.0	1.47915
CRCGN015_MCF10A.TP53.M_24H:I18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29055
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K50950731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67051
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1096
Brain - Spinal cord (cervical c-1)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.61552
BRD-K26479796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99552
BRD-K58041870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10499
CHD1	ENCODE Transcription Factor Targets	1.0	null
OVK-18	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-QVJO-0011-R4A-SM-2S1QL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.920292
Brain Lower Grade Glioma_LGG_TCGA-DB-A75K-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE195568_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
planum temporale, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.914091
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.541
REST_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE132694,GSE132717_0_v_2_meis1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mesothelioma_MESO_TCGA-SH-A7BD-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6869_PSMD1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01987
BRD-A05422420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22075
JF-96-HH81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213891
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.861754
clonidine-3172	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
abnormal eye morphology	MGI Mouse Phenotype Associations 2023	1.0	null
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.65083
fulvestrant-6925	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SRF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K21196859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40945
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K41620124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00576
GSE152441,GSE152442_0_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
BRD-K87754766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55797
Adrenocortical carcinoma_ACC_TCGA-OR-A5JP-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.37772
YY1-22570637-MALME-3M-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE195568_2_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prestwick-1100-4534	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE193258,GSE193259_5_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ifenprodil-5044	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IQ-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dropropizine-5531	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A98714080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03771
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XPVG-0826-SM-4B654	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.973646
Brain Lower Grade Glioma_LGG_TCGA-DB-5274-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
edrophonium chloride-5001	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OOBJ-0926-SM-48TDO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11082
BRD-K49472569	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54672
A549_PFI-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189733
Ovarian Neoplasms	CTD Gene-Disease Associations	1.0	1.25028
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.29257
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
NR2F2	ENCODE Transcription Factor Targets	1.0	null
Perturb_6459_KD_LKB1_SRP094725	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.97648
E2F1-20622854-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE169356_0_v_5_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WL46-0011-R5A-SM-3LK6V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30461
GSE147876,GSE147877_4_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
amantadine-4222	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_19_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.487685
isoniazid-7197	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A40Y-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
miconazole-1477	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
chloramphenicol-5466	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE152441,GSE152442_7_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF587	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26155
MZ in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.72691
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Craniofacial Abnormalities	CTD Gene-Disease Associations	1.0	1.07093
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE233679_14_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K16621460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21099
OCUBM	DepMap CRISPR Gene Dependency	1.0	4.28794
BRD-K17343593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6505
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HH-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-U3ZH-1726-SM-3DB79	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1642
BRD-K41746201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78709
GTEX-XOTO-0011-R1B-SM-4B65C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07023
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.53704
Pervasive developmental disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.116
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
thioproperazine-6265	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fluorocurarine-6219	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-8359-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K55877261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89234
CRCGN017_MCF10A.TP53.M_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.2029
LUDLU1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53035
SPI1	ENCODE Transcription Factor Targets	1.0	null
Sarcoma_SARC_TCGA-FX-A48G-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OC-10-FB51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236266
glafenine-7018	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A624-01A-22R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC8040704-jcav12p2673s2.xlsx-Up-regulated_genes_in_EBF1-Unnamed_0_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08165
PMC9314667-Table_1.xlsx-Regulons-ATF5_ATF5	Rummagene Transcription Factor Associations 2026	1.0	null
gallbladder	HPA Tissue Gene Expression Profiles	1.0	0.987788
Isopenicillin N synthase-like	InterPro Predicted Protein Domain Annotations	1.0	null
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCL6-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE213588_9_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219822
VZ in subgenual cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.24408
GTEX-QEG5-0426-SM-2I5GJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95278
precentral gyrus, right, bank of the precentral sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.40589
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.860825
CASKIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26658
H3K4me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SLC38A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34169
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.485507
GTEX-S7SE-0526-SM-2XCD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848452
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X585-0011-R4B-SM-46MVH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10631
tretinoin-966	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RAD21_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SEC31A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01989
E2F4-21247883-LYMPHOBLASTOID-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEG4-1226-SM-2S1P6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
EOL-1-CELL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K26620362	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06362
MYBL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.982025
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PLEC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09971
stomach_3b	HPA Tissue Sample Gene Expression Profiles	1.0	1.25416
E2F4	ENCODE Transcription Factor Targets	1.0	null
GTEX-Q2AG-0011-R1A-SM-2HMJI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48525
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_1132_KO_Myc_SRP168941	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.43992
GSE89057_0_v_1_sox5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K96997646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27743
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_5293_KO_Dgcr8_SRP137730	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.94606
cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K53379620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15014
GSE158458_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00373
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HCFC1	ENCODE Transcription Factor Targets	1.0	null
cinchonidine-7190	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K50943704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06778
9250_TRAPPC5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.58331
FU97	CCLE Cell Line Gene CNV Profiles	1.0	1.33291
GTEX-WZTO-0011-R1B-SM-3NMAR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30789
Central nervous system germ cell tumor	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.624
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K38557728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70445
PMC6122955-elife-33947-supp2.xlsx-NY8_v_NY15_DE_Bru-seq-HNF1A-regulated_genes_Bru-seq_after_shRNA_in_NY8_or_NY15_cells_-_related_to_Figure_7A_HNF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Neoplasm Metastasis	CTD Gene-Disease Associations	1.0	1.15055
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
tolbutamide-4540	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
GSE169356_0_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
protein modification process	GO Biological Process Annotations 2015	1.0	null
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.980655
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92484282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7232
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
rosiglitazone-6992	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CA-72-JV60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241321
5441_NACA_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.36169
CRCGN017_MCF10A.TP53.M_24H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17285
Preputial gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.761
LIVF001-016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82801
fulvestrant-5964	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE193258,GSE193259_2_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.26581
TEAD4	ENCODE Transcription Factor Targets	1.0	null
SMC3-22415368-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
3-acetamidocoumarin-4601	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
reticulotegmental nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.834621
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R7A-SM-2HMJP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41995
striatum_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.978934
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Liver	GTEx Tissue Gene Expression Profiles 2023	1.0	1.72394
CREB1	ChEA Transcription Factor Targets	1.0	null
genistein-1660	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-NL4W-0011-R6a-SM-2I3GA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934687
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Breast Cancer_Mammary Gland Tissue_GSE1378	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.01896
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858681
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Perturb_7760_KD_RRP6/DIS3_SRP337423	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.19224
PC-62-AQ92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.26401
SJCRH30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.941037
16p11 2 proximal deletion syndrome	WikiPathways Pathways 2024	1.0	null
SNU1077	CCLE Cell Line Gene CNV Profiles	1.0	1.35593
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37988
CORL105	CCLE Cell Line Gene Expression Profiles	1.0	1.4087
Male urethra	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.623
GTEX-OHPN-0011-R4A-SM-2I5FD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949225
GTEX-S341-1826-SM-3K2AB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
RERFLCAI	DepMap CRISPR Gene Dependency	1.0	2.58513
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-PQ-A6FN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.71051
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.229
small intestine	HPA Tissue Protein Expression Profiles	1.0	1.02578
YY1	ChEA Transcription Factor Targets	1.0	null
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K85401814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40872
gliquidone-6004	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LY-294002-6995	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TCF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.1425
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06178
GTEX-OHPN-0011-R2A-SM-2I5FB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954544
hexylcaine-5768	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
testis	HPA Tissue Protein Expression Profiles	1.0	1.02578
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5X1-0006-SM-3GIJZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AD-72-RI24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.680053
hsa-miR-1178	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
CRCGN015_MCF10A_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.32095
UQCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05927
MYC_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.50328
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MDAMB157	DepMap CRISPR Gene Dependency	1.0	2.23841
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21546
nicardipine-3215	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QVJO-1325-SM-2S1QX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98175
BRD-K55510118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13923
GSE116930,GSE116935_3_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
Large intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.989263
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
Chromosomal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
decreased heart rate	IMPC Knockout Mouse Phenotypes	1.0	null
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KP-N-YN	GDSC Cell Line Gene Expression Profiles	1.0	2.04259
ELK4	ENCODE Transcription Factor Targets	1.0	null
Perturb_7768_KD_EXOC5_DRP001280	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.18449
HCC44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.952334
BRD-K37906141	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2432
BRD-K21284411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33611
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4QT-1826-SM-2S1NJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
CTCF_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Senescence_frontal cortex_GSE1572	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.82753
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RWSA-0526-SM-2XCBC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936925
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE239844_6_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Unnamed_1_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S15-Table_S15_MR_resluts_of_brain_pQTL_and_small-vessel_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
salsolidin-4810	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OHPN-0011-R1A-SM-2I5GB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0653
BMI1_DN_MEL18_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
Perturb_8008_OE_TP53_SRP406950	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.92388
BRD-K31059261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00092
COLO-320-HSR	GDSC Cell Line Gene Expression Profiles	1.0	1.61582
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-N7MS-0011-R10A-SM-2HMJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21542
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREM	ChEA Transcription Factor Targets	1.0	null
REST_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160631
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XLM4-0011-R10A-SM-4AT5P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.887668
GSE239844_11_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
dorsal cochlear nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00668
JHH6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37777
H3K4me1_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Esophagus	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.85164
REST_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rolitetracycline-3369	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LY-294002-1019	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Early endosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.763
Lung Diseases	CTD Gene-Disease Associations	1.0	1.12426
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6221-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K66434795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04985
PAK5	Kinase Library Serine Threonine Kinome Atlas	1.0	null
GTEX-XOTO-0011-R8A-SM-4B65J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85892
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.11241
Cement gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.682
guanfacine-5256	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.37344
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bephenium hydroxynaphthoate-6466	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE195786_0_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ANGEL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13446
SB-203580-7061	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_8937_Mut_RB1_SRP220467	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.41345
BRD-K34243619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40585
Bone development disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.023
H3K27me3_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KP4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.50328
GSE48812_4_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
abducens nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.4637
anterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.93573
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.81422
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.860072
SREBF1	JASPAR Predicted Transcription Factor Targets	1.0	null
flunisolide-3828	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE233679_14_v_9_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
STK17B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16897
GSE119498_6_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.50822
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05231
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.34167
nialamide-3790	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GABPA_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SHSYSY+RA	BioGPS Cell Line Gene Expression Profiles	1.0	1.45141
GTEX-N7MS-0011-R11A-SM-2HMJS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46241
retroparafascicular area of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.48265
PMC10534007-Table_2.xlsx-S5_unique_up_MSC_B-721_elements_included_exclusively_in_BFTC905_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
REST_Panc1_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147876,GSE147877_4_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X4XX-0011-R10B-SM-46MWO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858275
H3K79me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
USF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Down Syndrome_Brain_GSE5390	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.46163
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
BRD-K82919339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13358
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-Row_names_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
oxidation-reduction process	GO Biological Process Annotations 2015	1.0	null
arcuate nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13349
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WZTO-2826-SM-3NM8P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13555
CBX3	ENCODE Transcription Factor Targets	1.0	null
BRD-K24907498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50391
CRCGN015_MCF10A.TP53.M_24H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1922
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07694
RNF25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26867
GSE150072,GSE169209_6_v_11_qser1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.96497
MAFG_02_189	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.66297
Perturb_15608_KO_Dnmt1_SRP247926	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.9367
GTEX-T5JC-2326-SM-32PMR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13209
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PLAG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	119.722
Perturb_16547_KO_Dusp6_SRP322434	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
zardaverine-4209	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PKNOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.487
CREB1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU475	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34312
Lung adenocarcinoma_LUAD_TCGA-55-6984-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216273,GSE216292_14_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SUZ12-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
ikarugamycin-866	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-P4PP-0326-SM-33HC4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18134
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.64747
ZNF263	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	87.683
GSE149075_3_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8143797-elife-62857-fig4-data2.xlsx-CAMTA1_ChIP_RNAseq_merged-Gene_CAMTA1	Rummagene Transcription Factor Associations 2026	1.0	null
pizotifen-5491	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ethionamide-4593	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05754
GSE203158_5_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.860825
Acute Myeloid Leukemia_LAML_TCGA-AB-2847-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213266
GTEX-WL46-0011-R7A-SM-3LK7X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59098
NCI-H810	COSMIC Cell Line Gene CNV Profiles	1.0	4.51153
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826474
KDM1A	ENCODE Transcription Factor Targets	1.0	null
brain	HPA Tissue Gene Expression Profiles	1.0	1.60171
Brain - Hypothalamus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.597753
PMC8040704-jcav12p2673s2.xlsx-Up-regulated_genes_in_EBF1-Unnamed_5_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07552
CA46	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.44503
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223556
oxaprozin-3794	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ACHN	CCLE Cell Line Gene CNV Profiles	1.0	1.41116
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-CREB3L1_CREB3L1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U3ZN-2226-SM-3DB88	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03373
thalidomide-5990	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K61795707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02525
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22951
REST_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K97318603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78085
GTEX-XOTO-0011-R7B-SM-4B64R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32417
SOX2-20726797-SW620-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-4631-01A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F6_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SKMEL28	BioGPS Cell Line Gene Expression Profiles	1.0	1.58497
NCIH2347	CCLE Cell Line Gene CNV Profiles	-1.0	-1.63662
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.31292
Perturb_5903_KD_DDX5_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.07445
Genetic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.096
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K60898929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45261
RGS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7632
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.5139
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5Q6-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EFE184	CCLE Cell Line Gene CNV Profiles	1.0	1.76679
dorsolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.73977
CAL-120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.86432
GTEX-OXRO-0011-R2A-SM-3NB1W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53679
NCI-H2126	COSMIC Cell Line Gene Mutation Profiles	1.0	null
alpha-estradiol-5207	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SMC3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN008_HEPG2_24H:A04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.67065
MYBL2	ENCODE Transcription Factor Targets	1.0	null
AG-012559-6884	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2910-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
increased circulating creatinine level	MGI Mouse Phenotype Associations 2023	1.0	null
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.948
RACK7-27058665-CHIP-SEQ-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WHSE-2926-SM-3NMBG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841109
SP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	143.749
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K52340217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08489
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.22979
LU-165	COSMIC Cell Line Gene Mutation Profiles	1.0	null
E2F4-21247883-LYMPHOBLASTOID-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4707-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.928013
GTEX-NL4W-0011-R9a-SM-2I3G1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906817
BRD-K02987495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49141
BRD-K79321447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24712
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908627
BT474	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.36104
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4c-WT1_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
496100559_FWM_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.2464
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LY-294002-6953	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PW2O-1926-SM-2S1OB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.12497
GSE220806_0_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WHSE-0011-R3A-SM-3P5ZM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19392
BRD-K90562751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50339
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.63715
ICC106	DepMap CRISPR Gene Dependency	1.0	2.96223
GTEX-Q2AG-0011-R2A-SM-2HMIT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15521
H4K20me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MN-2626-SM-32PMQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19743
AA-46-GL76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223597
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K79781106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17266
Benign familial infantile epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.544
DC-47-KV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.39146
calcium pantothenate-4189	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.55368
medial superior olive	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.2165
CRCGN015_MCF10A.TP53.M_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76555
GSE261563_3_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.878527
BRD-K90460185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30071
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.27735
GSE178714_1_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF-27219007-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-RWS6-0826-SM-47JXF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
GSE214382,GSE214383_4_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WVLH-0011-R7A-SM-3MJFB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929596
KLF5	JASPAR Predicted Transcription Factor Targets	1.0	null
UTP14C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49516
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
dicoumarol-4323	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04698
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	2.15924
KMS26	CCLE Cell Line Gene CNV Profiles	1.0	1.61222
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5701-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K47083242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04423
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203952
GSE210101,GSE210114_1_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174701_1_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11953091-12035_2025_4695_MOESM1_ESM.xlsx-s5-Supplementary_Table_5_Results_of_the_2-sample_pQTL_MR_on_insomnia_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PVOW-2726-SM-48TCA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827022
hydrochlorothiazide-1487	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XMD1-0011-R9A-SM-4AT49	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868717
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54I-01A-21R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K80630598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1275
JIYOYE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20375
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A562-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DH-A669-02A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ARID3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MT-0011-R5a-SM-2I3G6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858822
GTEX-RU72-0011-R2A-SM-2TF6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01806
NCI-H1623	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07552
PATU8902	DepMap CRISPR Gene Dependency	1.0	6.35642
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FF-86-NH56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213632
E2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.6524
Perturb_12206_KO_TP53_SRP287851	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.3804
GTEX-Q2AG-0011-R5A-SM-2HMJH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44274
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HM-01A-12R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE221327_8_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4962-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.09011
GTEX-T5JC-0011-R8A-SM-32PLM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11618
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.15877
A549_Ki16425_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151187
GSE145915_5_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
sulfacetamide-1695	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BB-20-UU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241013
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K02920459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75929
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5885-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
c-Myc:Max	MotifMap Predicted Transcription Factor Targets	1.0	null
EPHA4_drugactivation_229_GSE26523	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.76459
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7057_RAC3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.56789
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K28700379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46865
PMC6715699-41467_2019_11785_MOESM4_ESM.xlsx-CSL_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
meglumine-6445	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
dextromethorphan-2636	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RU72-0011-R7A-SM-2TF5U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26819
KLF14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	135.671
DU4475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.931992
valproic acid-1665	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
S0-EE-WJKI_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268369
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
(+/-)-catechin-3351	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05959
SOX2	ChEA Transcription Factor Targets	1.0	null
dexpropranolol-5814	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8421-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DKMG	CCLE Cell Line Gene CNV Profiles	-1.0	-2.56723
GTEX-Q2AG-0011-R11A-SM-2HMKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00306
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETV4_ETV4	Rummagene Transcription Factor Associations 2026	1.0	null
TK-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03203
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A-498	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24401
OVCAR433	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4017
DPF2_02_14	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59024
BRD-K00698280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50043
VZ in rostral cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.997622
metyrapone-5667	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K69565703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60729
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NCIH854	CCLE Cell Line Gene CNV Profiles	1.0	1.91277
GSE133516_0_v_3_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
JUND_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174302
GSE258991_1_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_14731_KD_SUPT6H_SRP181929	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
cochlear nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23479
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5EP-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
BOD1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43691
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BORCS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50538
CRCGN015_MCF10A.WT.HP_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19348
CRCGN015_MCF10A.TP53.M_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31532
oxaprozin-4352	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-Q2AG-0011-R4A-SM-2HMKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10058
BRD-K46620987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35445
GSE205976,GSE205978_2_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HF-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.859659
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSF1_KD_GDS1733_750_human_HeLa cells - 0 Hour	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-A5G1-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03639
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.31877
timolol-5280	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSU	DepMap CRISPR Gene Dependency	1.0	2.54276
A498	CCLE Cell Line Gene Expression Profiles	1.0	1.55949
imipramine-1685	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24324
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QF-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XOTO-0011-R6B-SM-4B65X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07648
DIAPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21443
methylbenzethonium chloride-3768	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
levothyroxine sodium-3249	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-UTHO-0011-R6A-SM-3GIJW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91347
Perturb_6906_KD_DDR1_SRP334383	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.01882
GTEX-RWS6-2326-SM-2XCB4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.966888
BRD-K93295557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04321
Carbamazepine_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0240185
BRD-K68086276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28146
mephentermine-4707	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE247084,GSE247087_0_v_1_cdyl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
laudanosine-2890	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RU72-0011-R11A-SM-2TF6J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0025
GSE175787_11_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98319
PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_down-regulated_in_Myc_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.877359
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPM-0426-SM-3TW8V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959677
minocycline-5496	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	1.0	1.1626
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-7173-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WWYW-3126-SM-3NB39	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01329
CD56+_NKCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.859248
clidinium bromide-3476	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
trichostatin A-6085	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE218949_0_v_1_cep20_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.858691
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RPL21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51861
oral mucosa	HPA Tissue Protein Expression Profiles	-1.0	-0.867575
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11411
CREB1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.054
salivary gland	HPA Tissue Protein Expression Profiles	-1.0	-0.867575
NFYB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE48812_4_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GB-57-XV52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23352
ATF2_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KE-37	GDSC Cell Line Gene Expression Profiles	-1.0	-1.62042
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.909051
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989373
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925722
KDM5B	ENCODE Transcription Factor Targets	1.0	null
GSE158834_2_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PA-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.052
xylazine-4066	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.41149
GTEX-UTHO-0011-R3A-SM-3GIK8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00606
GTEX-SJXC-0526-SM-2XCFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15876
external granular (germinal) layer of lower rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.02093
GTEX-R55F-0011-R6A-SM-2TF4L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934596
NCI-H2596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03313
GSE77108_4_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-R55E-0011-R8A-SM-2TC66	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939107
JUN_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU1J-1726-SM-2TF5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.624419
Brain Lower Grade Glioma_LGG_TCGA-DU-A6S3-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
0179445-0000-3633	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Hemorrhage	CTD Gene-Disease Associations	1.0	1.05015
Aorta	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.29528
EBF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.6739
BCB000040-7493	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ampicillin-6307	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9504
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.879655
SMC3_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10R-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
trichostatin A-3077	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.926791
alpha-yohimbine-6274	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06647
kinetin-6073	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25T-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7927_KD_ZFC3H1_SRP222099	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.6462
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.41149
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6941-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NP8	DepMap CRISPR Gene Dependency	1.0	2.24113
BRD-K37454185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.5987
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.874176
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204206
geldanamycin-864	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EGR1	ENCODE Transcription Factor Targets	1.0	null
A549_Iniparib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125514
demecarium bromide-6269	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
M07E	DepMap CRISPR Gene Dependency	1.0	2.09588
GTEX-OIZI-0626-SM-2XCEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
HUH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16077
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11831
Ovarian Diseases	CTD Gene-Disease Associations	1.0	1.43618
5279552-960	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S4Z8-0926-SM-4AD6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911704
todralazine-1677	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.12821
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
USF1_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Peripheral Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.03864
SUZ12-20075857-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.28342
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839204
GTEX-W5WG-2226-SM-4LMI3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86687
BRD-K31796953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90477
RAD21_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dysostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.173
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_brain microvascular endothelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
irinotecan-7498	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_9163_KD_Shp2_SRP351122	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.48651
NCIH854	CCLE Cell Line Gene Expression Profiles	1.0	1.44297
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
Teeth hard tissue disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.946
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
H3K9ac_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
KMS20	DepMap CRISPR Gene Dependency	1.0	2.764
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.933132
GTEX-XUW1-0826-SM-4BOP6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.943474
BRD-K69073616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28731
H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE214382,GSE214383_6_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
locus ceruleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.8277
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
propidium iodide-6277	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BFTC-905	GDSC Cell Line Gene Expression Profiles	-1.0	-1.92814
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE76425_0_v_12_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH1581	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44615
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
Attention deficit hyperactivity disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
GTEX-QDT8-0526-SM-3NMD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842271
GSE168401_1_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10944835-41467_2024_46639_MOESM4_ESM.xlsx-SD17-Supplementary_Data_17_Differentially_expressed_genes_according_to_homozygous_genotype_at_the_TWIST1_locus_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
FOXE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08524
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.441764
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.834826
pivampicillin-5046	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
G141	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1155	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XUZC-2026-SM-4BRW9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942913
RAD21_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RPA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02532
UF-98-OM26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202104
sw1463	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.777
CAL120	CCLE Cell Line Gene Expression Profiles	1.0	1.63675
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5983_KD_YBX3_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.3879
niflumic acid-7430	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K57357721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78108
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17854
GTEX-X638-0326-SM-47JY1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95687
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15621
Neoplasm Invasiveness	CTD Gene-Disease Associations	1.0	1.05386
RAD21	ENCODE Transcription Factor Targets	1.0	null
GSE210101,GSE210114_8_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.879655
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.946048
USF1_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.5135
monorden-836	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2714-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REST_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C2CD4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30464
hl60	HPA Cell Line Gene Expression Profiles	-1.0	-0.873641
midbrain reticular formation, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.42877
THAP1	ENCODE Transcription Factor Targets	1.0	null
GSE166184,GSE166185_1_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	1.0	null
5186223-885	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CHP-212	GDSC Cell Line Gene Expression Profiles	-1.0	-1.59327
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923571
GTEX-QVUS-0011-R6A-SM-3GACX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89208
GSE210870_0_v_2_snai1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K84959002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11747
Crohn's disease_Intestine - Large Intestine - Colon (MMHCC)_GSE6731	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.89532
GSE242083,GSE242098_3_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OS-01A-12R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE220520_5_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_9416_KD_Mecom_SRP356893	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.37245
cerebellar cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04341
H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE148252_5_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_retinal pigment epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K45723655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02929
GSE120612_7_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6668037-NIHMS1530019-supplement-3.xlsx-AR_differential_binding-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Age At Menarche	DisGeNET Gene-Phenotype Associations	1.0	null
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.89039
gallbladder	HPA Tissue Protein Expression Profiles	1.0	1.02578
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-XOTO-3026-SM-4B65M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07431
Pancreas	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Rectum adenocarcinoma_READ_TCGA-DT-5265-01A-21R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.75444
GTEX-RM2N-0526-SM-2TF4N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.906913
GSE200673,GSE200691_1_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
fluphenazine-1662	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1138
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K75657700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28629
BRD-K27997230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21171
GSE228619_0_v_1_cdh11_human	RummaGEO Gene Perturbation Signatures	1.0	null
atracurium besilate-1702	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K01793276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.35764
STOCK1N-35874-6561	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE120200,GSE127269_1_v_2_asxl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
cefotiam-5361	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7399-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BE-31-XV38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.326574
superior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.896923
GTEX-TSE9-0011-R1A-SM-3DB7E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06814
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE234514,GSE234516_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_astrocyte of the spinal cord_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4174-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE175787_4_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06511
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937487
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HY-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210101,GSE210114_6_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Skeletal Muscle Female	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.27265
GTEX-T6MN-2526-SM-32PMN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43012
JURKAT, CLONE E6-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
ZNF816	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.3799
NCI-H2369	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.944484
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A623-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
20460542-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
H3K4me1_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.280427
Prenatal Injuries	CTD Gene-Disease Associations	1.0	1.18652
TEAD4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0011-R7A-SM-32PME	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57654
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GOSR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13217
HCC202	CCLE Cell Line Gene CNV Profiles	1.0	1.37029
GTEX-XLM4-0011-R9A-SM-4AT45	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37466
BRD-K60937893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73171
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-WT1_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
Colorectum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
quinisocaine-2807	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K22139757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.92001
ATF	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE197555_0_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE162590_1_v_0_gsx2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FA-36-VA24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229919
benzydamine-7169	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-eTable_38_Cis-instrument_Mendelian_randomizaion_screen_of_1_901_cortical_proteins_on_lifetime_smoking_behavior_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K13085116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29532
GSE119978,GSE180930_6_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHD2	ENCODE Transcription Factor Targets	1.0	null
PMC12640707-NIHMS2124006-supplement-Supplemental_tables.xlsx-Supplemental_Table_S4-Supplemental_Table_S4_Genes_commonly_upregulated_in_both_clones_of_ZFX-depleted_HEK293T_cells_in_Ni_et_al_2020_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL4W-0011-R10A-SM-2I3DY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918884
CTCF_fibroblast of the aortic adventitia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	86.631
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KALS1	DepMap CRISPR Gene Dependency	1.0	4.09632
A549_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152089
sulfanilamide-6810	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K90475322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31308
GSE203329_0_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.946
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
NCI-H23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16216
GTEX-NPJ7-0011-R11A-SM-2I3E8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941896
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.20125
BRD-K60946512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4237
PMC8481886-Table_1.xlsx-A_subsets-iMSC_fetal_MSC_UC_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
bone marrow	HPA Tissue Protein Expression Profiles	-1.0	-0.867575
GSE200839,GSE233826_3_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07787
head of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.58262
CRCGN008_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.388
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XOTO-0011-R11B-SM-4B64O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.043
PMC8844187-Table_2.xlsx-prostate-DLX1_DLX1	Rummagene Transcription Factor Associations 2026	1.0	null
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.862832
CerebellumPeduncles	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.83134
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.41963
YY1	ENCODE Transcription Factor Targets	1.0	null
fulvestrant_homo sapiens_gpl570_gse22533	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-8673-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MM.1S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.856389
ZNF257	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.1589
BRD-K06408981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56692
BRD-K56591923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49399
H3K27me3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-0011-R9a-SM-2YUN5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08709
HKBMM	DepMap CRISPR Gene Dependency	1.0	3.38567
microphthalmia	IMPC Knockout Mouse Phenotypes	1.0	null
TAF1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7UY-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
Bicalutamide_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0149448
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMARCC1	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SNU182	CCLE Cell Line Gene CNV Profiles	1.0	1.84001
GTEX-WY7C-2526-SM-3NB2N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13626
GSE205163,GSE205164_1_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
amygdaloid complex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.849965
EB2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.836017
BRD-K11404512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04037
LNCaP-95 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.083
FOXP2	ENCODE Transcription Factor Targets	1.0	null
p3h3	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.793
NCIH196	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43262
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.982025
SP4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K45893504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29559
REST_Panc1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PVOW-0726-SM-2XCF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.856303
GTEX-WEY5-0226-SM-3GIKN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TCF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.6867
ZFP14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.2006
GSE163240_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
F36P	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45241
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17094
GSE152441,GSE152442_0_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RP58	MotifMap Predicted Transcription Factor Targets	1.0	null
A549_Resveratrol_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138392
3308_GBF1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.22352
RPL23A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84447
Waist Circumference	dbGAP Gene-Trait Associations	1.0	0.443956
BRD-K36451640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35591
BRD-A89575866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.61547
GSE114284_1_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cefamandole-3436	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
19204204-SupplementaryTable5	GeneSigDB Published Gene Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5835-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RELA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7778
GTEX-X585-0011-R1B-SM-46MVE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13333
GTEX-V1D1-0526-SM-4JBGW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998053
BRD-K45712538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17386
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7SE-0011-R5A-SM-2XCDA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18026
ZSCAN22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21239
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_7926_KD_ZCCHC8/ZFC3H1_SRP222099	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.31138
abnormal tail morphology	IMPC Knockout Mouse Phenotypes	1.0	null
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K20520611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26951
GSE233679_6_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K05414181	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08297
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
epididymis	HPA Tissue Protein Expression Profiles	-1.0	-0.867575
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.2274
NIHOVCAR3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.774
AU565	DepMap CRISPR Gene Dependency	1.0	3.00042
BRD-K87776049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01461
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07416
ZNF519	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24448
BRD-K37790543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34321
COLO-818	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.935317
GSE189941_1_v_2_kdm4c_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K95569142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.214
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
hypothalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-U3ZH-1926-SM-4DXTR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981567
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222638
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.300294
topiramate-915	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
REC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.50842
Uterine Carcinosarcoma_UCS_TCGA-N5-A59F-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Autistic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.588
GTEX-PVOW-0011-R1A-SM-32PL6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.970948
BRD-K63093217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3834
GTEX-WHSE-0011-R4A-SM-3P5ZN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4112
BRD-K98008739	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31673
Lung adenocarcinoma_LUAD_TCGA-55-8620-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6WZ-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1504
Optic cup	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.867
KP3	CCLE Cell Line Gene Expression Profiles	1.0	1.90759
H3K79me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AA-85-LB25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269523
benzonatate-5435	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K36me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE231891_1_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
19204204-SupplementaryTable1	GeneSigDB Published Gene Signatures	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-PLZ6-1626-SM-3NB23	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83409
6863_PSMC6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.07138
enlarged thymus	IMPC Knockout Mouse Phenotypes	1.0	null
cisplatin_homo sapiens_gds3910	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K55399138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42044
BRD-K01734019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26496
PMC10079833-41467_2023_37542_MOESM11_ESM.xlsx-Sheet1-Supplementary_Data_10_Significantly_differentially_expressed_genes_identified_in_IGF2BP1-KD_cells_compared_to_control_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K18334106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48973
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26491
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-VB-A8QN-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
sertaconazole-3550	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_5968_KD_SUV39H1_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.3463
CTCF_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.992716
GTEX-P78B-0726-SM-2S1O2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
mecamylamine-7023	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K36271521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21231
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100407_FWM_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.2864
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.228
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55E-0011-R4A-SM-2TC5H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935608
GTEX-RNOR-0011-R4A-SM-3GAD3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2022
Kidney renal clear cell carcinoma_KIRC_TCGA-EU-5905-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XLM4-0011-R2B-SM-4AT5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08452
ETS1-22383799-G1ME-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K61354849	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07901
KIF21B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2631
BRD-K82827604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08475
PMC9529122-pone.0274785.s002.xlsx-S1_Table-S1A_Table_Differentially_expressed_genes_in_HeyA8_overexpressin_ZNF521_vs_HeyA8_control_cells_ZNF521	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4269325-NIHMS634665-supplement-supp_table4.xls-H3K27me3_TRIM37_KD-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPU-0011-R7A-SM-2XCAB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08177
786-O	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.60387
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.279
GTEX-WVLH-0011-R4A-SM-3MJFS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02826
GSE174701_1_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Chromosome 16p11.2 duplication syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.781
A549_JNJ-7706621_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154356
AGS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.59142
BRD-K86077185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75898
IMR32	DepMap CRISPR Gene Dependency	1.0	2.64492
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE236486_1_v_2_arnt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
E2F4	ChEA Transcription Factor Targets	1.0	null
ST13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31451
GTEX-XYKS-2626-SM-4BRUT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876194
BRD-K62794454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04233
RRP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.50355
GSE213588_9_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3067
spironolactone-6255	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K46313713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35262
BRD-K18142082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31136
GTEX-RU72-2926-SM-2TF66	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904635
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BX-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.544
GSE147876,GSE147877_4_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JMSU1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51832
Brain Lower Grade Glioma_LGG_TCGA-HW-A5KJ-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6789-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cell body fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.591
Neoplasms	CTD Gene-Disease Associations	1.0	1.66382
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_REST_21632747	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE240258_0_v_1_prmt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H1623	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.36716
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ethoxyquin-4321	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.70414
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.691801
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.18321
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303852
tolnaftate-1501	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
7519_RPS28_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.13269
androsterone-5696	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K34004579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17735
GTEX-X585-0011-R6A-SM-46MVJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18672
colon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE210101,GSE210114_0_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K91085913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37024
GTEX-XLM4-0011-R6A-SM-4AT4B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.911387
INSM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.625
GTEX-WZTO-0011-R6B-SM-4E3J6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14325
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.6472
Perturb_5908_KD_FUS_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.53406
COLO-680N	GDSC Cell Line Gene Expression Profiles	-1.0	-1.59235
BRD-K88384015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31221
GSE189609_1_v_0_hax1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23575
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.950383
GSE258991_5_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-A47B-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN008_HEPG2_24H:L17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03315
PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1d-List_of_2302_of_genes_differentially_regulated_by_SOX2_FDR_0_1_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
domperidone-2655	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
sparteine-4568	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Uterine Cervical Neoplasms	CTD Gene-Disease Associations	1.0	1.3085
H3K4me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.76061
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.03632
GTEX-QVJO-0011-R5A-SM-2S1QM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03668
GTEX-QLQ7-0526-SM-2I5G3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889783
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12188
E2F6	ENCODE Transcription Factor Targets	1.0	null
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10806738-mmc2.xlsx-Table_S1-Table_S1_Table_of_significantly_adjusted_p-valued_0_05_up-regulated_genes_log2FC_1_in_MAX-R60Q_transfected_HEK293_cells_relative_to_MAX-WT_transfected_cells_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
GSE153836_14_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.989494
GSE221327_6_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
RDES	DepMap CRISPR Gene Dependency	1.0	4.2571
AUTS2-25519132-293T-REX-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
KYSE-50	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-R55E-0011-R9A-SM-2TC6C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871585
CTCF_epithelial cell of proximal tubule_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.41139
HEP G2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23328
digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-719	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05098
Brain Lower Grade Glioma_LGG_TCGA-QH-A6X4-01A-51R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
droperidol-5690	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BV-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PSMB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38389
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-05A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
GSE147876,GSE147877_2_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135514_2_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WWYW-3026-SM-3NB36	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16066
BRD-K78432272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61835
PPTC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17515
mometasone-5541	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0866
GSE202434,GSE202438_13_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-NL4W-0011-R11A-SM-2I3DW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26607
DOV13	CCLE Cell Line Gene CNV Profiles	1.0	1.71683
BRD-K03765511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20542
A549_Andarine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158938
hippocampus (hippocampal formation)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01353
Chromosome Aberrations	CTD Gene-Disease Associations	1.0	1.57806
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE73381,GSE73382_0_v_1_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE224556,GSE224557_8_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0438
cerebellum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.949667
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
oxidoreductase activity	GO Molecular Function Annotations 2015	1.0	null
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.779143
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CiliaryGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.841367
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.998169
BRD-K16526787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47704
BRD-K52842821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39641
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.46154
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL-148	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.71899
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.877262
A549_FLLL32_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128886
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EPHB2_drugactivation_228_GSE26523	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.42742
GTEX-T6MN-0011-R6A-SM-32QP8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.966194
lomustine-7045	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T2IS-0011-R6A-SM-32QP2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854684
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
786O	CCLE Cell Line Gene Expression Profiles	1.0	2.02824
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-NJ-A55R-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDAMB436	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.21422
GSE148263_6_v_9_trim3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
USF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ParietalLobe	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.49284
stomach	HPA Tissue Gene Expression Profiles	1.0	1.0516
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
putamen, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.42434
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.78799
Spondylocostal dysostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.776
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.59174
amygdalostriatal transition area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.850737
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4038
Head and Neck squamous cell carcinoma_HNSC_TCGA-TN-A7HL-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-N7MT-1226-SM-2D7W4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85695
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.832199
BRD-K28029070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.36605
CRCGN017_MCF10A.TP53.M_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.72962
CYBA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48947
GSE184087_4_v_3_tert_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874547
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907035
central gray of the pons, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.70873
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14576
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.516
GTEX-R55E-2526-SM-2TC6H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0407
Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q7-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K03659510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06761
VZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00901
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.40902
SP1	ENCODE Transcription Factor Targets	1.0	null
haloperidol-7003	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-JUN_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245458
GSE119498_2_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
3479_GOSR2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.40468
alpha-estradiol-1210	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.67865
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sodium Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
A549_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143395
PHB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62418
Sleep disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.541
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
heart_5b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.68083
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
antimycin A-5053	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
olfactory part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19051
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.6099
BRD-K62547690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07499
GTEX-N7MT-0011-R7a-SM-2I3FZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40063
GTEX-U8XE-0005-SM-3DB8I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.992571
GSE119498_0_v_5_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cefapirin-2730	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29Q-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver Diseases	CTD Gene-Disease Associations	1.0	1.31716
ACHN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202292
GSE165548_2_v_1_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GPRIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23668
1747_COG8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.17647
tanespimycin-916	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K74363294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25993
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13876
BRD-K59606563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48881
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-Unnamed_4_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4b-WT1_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE87615_0_v_3_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XLM4-2926-SM-4AT59	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06382
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.47385
Adrenocortical carcinoma_ACC_TCGA-OR-A5JG-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBTB33_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	185.195
BRD-K72842159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38107
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5703-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.798536
BRD-K29083370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17437
BRD-K27540772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.63565
GSE147893,GSE147897_2_v_1_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K65633211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90458
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_WERI-Rb-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
decreased circulating alkaline phosphatase level	MGI Mouse Phenotype Associations 2023	1.0	null
pempidine-6027	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
S0-EE-Y7IR_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288609
mRNA_CDX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.91781
rosiglitazone-5593	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WWYW-0011-R6A-SM-3NB3G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934684
PMC3435504-msb201237-s2.xls-Supp_Table_4a-SP1_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.961048
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36563
FOXA1	ENCODE Transcription Factor Targets	1.0	null
8557_STX5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.4386
co-dergocrine mesilate-4071	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_foreskin fibroblast_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19328
CTCF_astrocyte of the spinal cord_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_choroid plexus epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.28342
chlorpropamide-5391	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
COV644	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.56441
benzylpenicillin-6839	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SW1271	CCLE Cell Line Gene CNV Profiles	1.0	1.44146
REST_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:E12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3439
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
CRCGN017_MCF10A.TP53.M_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.3739
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TFAP2A	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE132759_4_v_5_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMARCC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RELA	JASPAR Predicted Transcription Factor Targets	1.0	null
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.28851
H3K4me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K07981644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06079
RRP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26378
BRD-K10959171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36495
striatum_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.924492
BRD-K54476947	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03152
PMC9859043-elife-78421-supp9.xlsx-LHX8_P-Gene_symbol_LHX8	Rummagene Transcription Factor Associations 2026	1.0	null
HDAC2_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC6	ENCODE Transcription Factor Targets	1.0	null
9857_WEE1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.02192
colforsin-7104	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30411
GSE195568_3_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T2IS-0011-R2A-SM-32QPF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14136
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
VZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.827164
GSE196699_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WZTO-0011-R10B-SM-4E3KB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994386
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6887
Creb3l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.5528
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09472
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tolazamide-4003	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-NPJ7-0011-R6a-SM-2I3G7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886575
CAR-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.994016
gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
18024211-Webtable1	GeneSigDB Published Gene Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J5-01A-21R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.488583
PMC6855629-pone.0225186.s008.xlsx-Sheet1-DEGs_downregulated_in_SK-N-SH_MEIS1_OE_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JC-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HOXA10_HOXA10	Rummagene Transcription Factor Associations 2026	1.0	null
P53-21459846-SAOS-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE165308_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K97943226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52672
anterior (rostral) cingulate (medial prefrontal) cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.971814
BRD-K66039243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26208
GTEX-WFG8-0426-SM-3GILD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965294
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12144
genistein-6994	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y0-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39V-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TSE9-0011-R5A-SM-3DB7J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02613
BRD-K00789767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43136
PMC8586238-41467_2021_26788_MOESM6_ESM.xlsx-S2A_CDE_genes-S2A_CDE_-_genes_of_the_two_CCD_genes_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12019
ciclosporin-4586	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QDVJ-0005-SM-2TC5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06835
aztreonam-5535	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE146074_10_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147876,GSE147877_2_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223908,GSE223909_1_v_6_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T5JW-1726-SM-3GADN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824429
DU145	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.54562
GSE130401_4_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
acetylsalicylic acid-5564	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K31337291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32071
docebenone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06843
JUN_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
glycocholic acid-5316	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883568
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08398
CRCGN014_HEPG2_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29269
Fatty Liver	CTD Gene-Disease Associations	1.0	1.50323
SKNO1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.17368
COLO 205	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.855564
GTEX-N7MT-0011-R3a-SM-2I3GC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20746
KLF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	113.061
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.64171
Perturb_7467_KD_AFF4/AFF1_SRP136956	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.49065
CREB1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.71552
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4823830-ncomms11171-s4.xlsx-high_in_shRNA_TCF1-GeneSymbol_HNF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AH-2026-SM-2S1PX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-T6MN-0011-R5A-SM-32QPD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30439
papaverine-6245	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19583
BRD-K35799753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16302
GTEX-PX3G-1626-SM-2S1PT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
TARDBP_KD_GDS3730_118_human_HEK293E	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
macromolecule modification	GO Biological Process Annotations 2015	1.0	null
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMARCB1	ENCODE Transcription Factor Targets	1.0	null
atropine oxide-2216	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
REST_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K82781769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05291
GSE165548_2_v_13_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
REST_Panc1_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K26361872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26435
GSE138863_2_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain morphology (MOSTest)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.23979
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213048_1_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Meesmann corneal dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37988
IGROV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WK11-2526-SM-3NM9Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12857
GSE173201_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K17675814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20238
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212366
chlorcyclizine-3810	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K33064989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49599
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.42589
PMC7773934-Table_1.XLSX-Table_S2-Supplementary_Table_2_TBX22_co-expressed_genes_detailed_results_TBX22	Rummagene Transcription Factor Associations 2026	1.0	null
OC-10-FB51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.744032
Perturb_13841_KO_Prox1_SRP286061	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.02639
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30383
diphenhydramine-1708	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE216273,GSE216292_14_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EFR3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08205
DETROIT562	COSMIC Cell Line Gene Mutation Profiles	1.0	null
VZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.895421
GTEX-OHPM-0726-SM-3LK7A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869385
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903826
beta-escin-4544	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
biological_process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TP63-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
REST_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ovary	HPA Tissue Protein Expression Profiles	-1.0	-0.867575
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.952334
SIN3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
trichostatin A-4526	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Abdominal obesity-metabolic syndrome 1	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.096
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125219,GSE125221_5_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
REST_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE205550,GSE205552_2_v_3_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.338
SW1783	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Delamanid_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0168735
HPBALL	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67794
GTEX-X4XX-0011-R11A-SM-46MWQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878872
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27476
CTCF_fibroblast of pedal digit skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00611
496100643_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.09609
CTCF_fibroblast of foreskin _hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Grey cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.694
HCoV-EMC2012_7Hour_23631916_GSE45042	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.73065
GTEX-O5YT-1626-SM-32PK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DCLRE1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1835
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05867
GSE147876,GSE147877_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17063
PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-ATF3_TGAYRTCA_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
isoetarine-3451	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
wortmannin-977	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GATA3-21867929-TH1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE207282_1_v_0_polydatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
valproic acid-1060	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K44643967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01754
CRCGN008_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15335
Perturb_2867_Mut_FBXW7_SRP404927	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
abnormal thymus morphology	IMPC Knockout Mouse Phenotypes	1.0	null
CTCF_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K75869095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4603
BRD-K95121261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72671
GSE147876,GSE147877_4_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
placenta	HPA Tissue Protein Expression Profiles	1.0	1.02578
skimmianine-6242	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-X4XX-0011-R4B-SM-46MWL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983487
GTEX-XUYS-0005-SM-47JZ2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-3.41306
raphe magnus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.962857
fenoterol-5432	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K07695007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43825
CTCF_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVCA420	DepMap CRISPR Gene Dependency	1.0	5.53633
decreased heart rate	MGI Mouse Phenotype Associations 2023	1.0	null
POLR2AphosphoS2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATP2C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26607
HDAC2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GA-28-SS67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208109
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5159-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Zfp809	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.0997
BRD-K15620114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11919
GSE157555,GSE157556_4_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.413982
H3K79me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
waist circumference	GAD Gene-Disease Associations	1.0	null
Benign familial infantile seizures 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.398
GTEX-SSA3-0326-SM-32QPS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04043
CRCGN014_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3764
lateral parabrachial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.935277
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04797
Perturb_14091_OE_MIR372_SRP075051	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.66998
Perturb_1415_KD_Smc1a_SRP062844	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.2489
GSE121824,GSE121826_0_v_8_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
ISTMEL1	DepMap CRISPR Gene Dependency	1.0	2.24712
orlistat-6388	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hydroxyachillin-4797	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4813-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
REST_Panc1_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
USF2	JASPAR Predicted Transcription Factor Targets	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EC-01A-21R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC4006	CCLE Cell Line Gene CNV Profiles	1.0	1.54139
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.68083
GSE216273,GSE216292_14_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Droxinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159292
GTEX-T5JC-2426-SM-3NMDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22118
496100538_HIP_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01076
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GRANTA-519	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.17934
PBX3	ENCODE Transcription Factor Targets	1.0	null
CREB1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Thymus-medullary thymic epithelial cell	Tabula Sapiens Gene-Cell Associations	1.0	2.10282
GSE119978,GSE180930_6_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X261-0011-R10B-SM-4E3JT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01673
Prdm5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.6446
PMC9714459-DataSheet3.xlsx-Supplement_3A-1166_common_elements_in_MSC_and_Fibroblasts_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
methacholine chloride-6248	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
YBX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7687
RPL35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84113
calcium pantothenate-4775	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.980655
mephenytoin-6158	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RVPU-0011-R10A-SM-2XCAH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05126
BRD-K30121969	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05418
GTEX-R53T-0326-SM-48FEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17769
PHF8	ENCODE Transcription Factor Targets	1.0	null
Sarcoma_SARC_TCGA-DX-A3UC-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pirenperone-5274	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25X-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.52127
FOXP1-21924763-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.541
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cefazolin-4708	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QMR6-0011-R5A-SM-32PKT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900672
SMARCB1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-97-7547-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.612941
16643655-1300GenesList	GeneSigDB Published Gene Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_5365_KO_Mettl14_SRP297324	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.55768
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876103
mRNA_EOMES_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
CTCF_MCF-7_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nes	HPA Cell Line Gene Expression Profiles	-1.0	-1.24496
BRD-K15930345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08187
BRD-K57286317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67268
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881018
HS-SULTAN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.33923
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.38669
dactinomycin_homo sapiens_gpl7172_gse12459	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K40219231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03034
REST_PFSK-1_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBM39_02_151	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.14296
MDA-MB-231	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07552
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.68693
CTCF_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFON-2326-SM-3LK7M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60964
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.5998
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
supramarginal gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.25906
ARID3A	ENCODE Transcription Factor Targets	1.0	null
JUND_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
STAT3	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5000-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GOS3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.94172
BRD-K21503128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19784
GSE174701_4_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ATXN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08019
PAK6	Kinase Library Serine Threonine Kinome Atlas	1.0	null
NR2F2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20086
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-0011-R1A-SM-3TW8G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.972993
BRD-K51600962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04047
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
abnormal digit morphology	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K77345736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36994
GSE213588_9_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12826982-mmc5.xlsx-Table_S4-Supplementary_Table_S4_Differentially_Bound_Down-regulated_Peak-Related_Genes_in_Flag-SOX3-HSV-1_vs_Flag-SOX3-Mock_SOX3	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH810	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
CTCF_GM12873_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C2orf15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78373
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE120612_4_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
harmalol-5495	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K01095342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20879
brain_a	HPA Tissue Sample Gene Expression Profiles	1.0	2.41412
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K77990919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03388
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K85802892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02502
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE128634,GSE128636_1_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LC1F	CCLE Cell Line Gene CNV Profiles	1.0	1.4218
GSE144231_4_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
supramammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.928105
GSE188458_2_v_4_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
FNTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10943
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PFEIFFER	CCLE Cell Line Gene CNV Profiles	1.0	2.2572
putamen, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.7701
Colon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MHH-NB-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.963763
BRD-K80921954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8218
REST_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Syp1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.64
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE114284_4_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
promethazine-5317	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE210101,GSE210114_6_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4017
hippocampus (hippocampal formation)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06133
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K13122526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3806
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWO3-0011-R2A-SM-2S1OX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935977
BRD-K33891642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37843
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4017
paraventricular nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.27992
vinpocetine-3174	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4430-01A-02R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RWSA-1326-SM-47JX9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963726
CRCGN015_HEPG2_48H:F15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3634
BRD-K30738175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68677
ACHN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01286
H3K4me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC4856960-supp_gkv1471_nar-01762-z-2015-File012.xlsx-GO_common_7H-HIF1_chip-Common_elements_in_chip7h_and_chip_hif1_2530_official_gene_symbols_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
COR-L26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.59693
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158632_2_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WL46-0011-R1A-SM-3LK6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30189
ELF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WM793B	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K98117883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45528
BRD-K28885073	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06466
PTPN12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36054
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
uterine cervix	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null