association	dataset	threshold value	standardized value
PMC11912729-12967_2025_6368_MOESM1_ESM.xlsx-S5-S5_Identification_of_Genes_Causally_Linked_to_IPF_through_MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Ovary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.08126
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7826
Vermiform appendix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.238
PMC3607232-mmc1.xls-RS411_SEM_common_AF4_MLLN_K79Me-MLL_AF4_H3K79me3_SEM_n_2490_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
C1orf116	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43566
Respiratory chain complex IV	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.194
GSE208254_3_v_1_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.98407
3557_GSTCD_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.62072
ATPase inhibitor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.124
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.53228
GSE137914_4_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112761,GSE112767_4_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Skin - Sun Exposed (Lower leg)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.37918
RARA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.1824
PMC10290283-biol-2022-0622-sm3.pdf-223-ZNF576_ZNF576	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226114,GSE226116_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.441
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KLE	DepMap CRISPR Gene Dependency	1.0	3.7361
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim22_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PSMB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28698
GSE227592_5_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE255432_7_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03958
GSE178340_5_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE133329_0_v_3_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
SPRTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03039
SLC16A8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07784
PMC3371315-NIHMS350140-supplement-12.xls-MCF7-T47D-SK-453_Down_Common_xl-Supplementary_Table_5_Luminal_Signature_Genes_decreased_in_all_four_cell_lines_MCF7_T47D_MB-453_SKBR3_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
Schizophrenia	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.82218
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.517163
SLC37A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00355
HAP-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.223
GSE196671_6_v_1_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140936,GSE140938_2_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3753
GSE226114,GSE226116_2_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE227891_5_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242049_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Tricarboxylic acid cycle enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.208
MRPL57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03287
mitochondrial inner membrane	GO Cellular Component Annotations 2023	1.0	null
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
3086_FIP1L1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01586
decreased circulating glucose level	IMPC Knockout Mouse Phenotypes	1.0	null
Dendritic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.796
1410_CDC73_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.655315
PMC11976845-pr4c00864_si_003.xlsx-Data_S2E_HeLa_LF-Unnamed_4_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
CSK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3903
496100411_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.22104
GSE179974_3_v_1_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
6845_PSMA5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.606005
GSE158834_11_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
7178_RBM48_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06344
REV3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21975
A549_Tie2 kinase inhibitor_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126286
GSE239578_0_v_6_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10203545-Table_4.xlsx-LM7_underrepresented-DMRTA1_DMRTA1	Rummagene Transcription Factor Associations 2026	1.0	null
T3M5	DepMap CRISPR Gene Dependency	1.0	2.11422
GSE185944_2_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_6_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE161170,GSE161268_1_v_3_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112762,GSE112767_1_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2490_EEF2_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04043
7438_RPL14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.603921
GSE135350_2_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE94849_7_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Twitch muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.242
PMC8208823-mmc2.xlsx-CDX2-KO_epithelial_DEG-feature_CDX2	Rummagene Transcription Factor Associations 2026	1.0	null
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	2.32106
PMC6928094-395_2019_765_MOESM7_ESM.xls-DEGs_AR7_vs_Pre-patterned-List_of_differentially_expressed_genes_in_AR7_vs_Pre-patterned_cells_THRA	Rummagene Transcription Factor Associations 2026	1.0	null
Epithalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.93
ERCC6L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26447
GSE239578_2_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201668_0_v_1_ncor2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_SB431542_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156399
GSE180951_6_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
organelle inner membrane	GO Cellular Component Annotations 2023	1.0	null
GSE227592_13_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6187090-mmc1.xlsx-TP53_positive-Symbol_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE62843,GSE64371_4_v_0_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE161295_4_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
1441_CDK7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.671073
6798_PRPF40A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.565519
4954_MED31_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.07177
GSE119345_2_v_4_bexarotene_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9634663-DataSheet10.xlsx-K562-MYC-AID_RNA-Seq_1326_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
Hamstring muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.783
PC3_PROSTATE	CCLE Cell Line Proteomics	1.0	3.10098
GSE217541,GSE217543_3_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
AXL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31554
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Hematopoietic cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE217541,GSE217543_3_v_1_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.596
1781_COPS5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12806
Aerobic respiration and respiratory electron transport	Reactome Pathways 2024	1.0	null
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
increased circulating aspartate transaminase level	MGI Mouse Phenotype Associations 2023	1.0	null
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3334
GSE143994_2_v_3_ythdf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
2324_DOCK6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.653901
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
Diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.614
GSE102467_1_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
10994_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.50593
EN	DepMap CRISPR Gene Dependency	1.0	4.16593
U2904	DepMap CRISPR Gene Dependency	1.0	2.92264
496100406_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.79664
7432_RPL10_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.32293
Adrenal Gland	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.893346
DIABLO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98273
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Uterus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.723
GSE239844_1_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA_high-signal_selected_bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
MOV10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53443
GSE86507,GSE86509_0_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
8651_TAF10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.544166
K562_NVP-BSK805 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202579
PYGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37816
a2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.7
Systemic lupus erythematosus	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.8
GSE158815_1_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_SL-327_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145593
GSE196104,GSE196106_3_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE115395_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTV1DM	DepMap CRISPR Gene Dependency	1.0	3.14215
GSE84678,GSE93902_1_v_2_bcl11b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLC66A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14842
Foxo1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.1861
CCNP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61385
PMC11093744-41592_2024_2172_MOESM3_ESM.xlsx-ELP-genes_NR5A1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211286_4_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12903452-mmc5.xlsx-ST2-2_OCT4_Off_Targets-Target_Gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
Intrinsic component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.612
GSE210662_3_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	1.0	null
DACH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03064
GSE142019,GSE142021_10_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CNS cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.904
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-3_E2F2-Gene_E2F2	Rummagene Transcription Factor Associations 2026	1.0	null
Organelle biogenesis and maintenance	Reactome Pathways 2024	1.0	null
GSE158320,GSE183351_0_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211177,GSE211178_0_v_1_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10721014-pone.0295542.s010.xlsx-Table_S9-Table_S9_Spearman_s_correlation_between_the_expression_levels_of_ESRRA_and_OXPHOS_subunits_genes_ESRRA	Rummagene Transcription Factor Associations 2026	1.0	null
ETS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9385
CEP43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02705
PMC6724602-mbc-30-1272-s007.xlsx-EGR1_Binding_Sites-Egr1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE240439_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.818
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
HEBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64753
PMC11585558-41467_2024_54547_MOESM8_ESM.xlsx-TP53_vs_WT_DEG_FFPE-gene_name_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
ERF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5131
Autism spectrum disorder or schizophrenia	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.33979
FCGRT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54696
Organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
PRDM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.5867
Integral component of organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.248
PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE151494_8_v_3_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_13_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Helper T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.623
GSE133213_6_v_15_znrf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Eplerenone_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0154985
GSE166783_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE80446_0_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
7166_RBM25_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.541371
Muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC7657662__F6	PFOCR Pathway Figure Associations 2023	1.0	null
Chloroplast thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.506
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.700144
T-lymphoblastic leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.613
Organelle inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.014
FLNC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35835
INS-1E cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.194
proton-transporting ATP synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.399
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9601
PMC6724602-mbc-30-1272-s007.xlsx-EGR1_Binding_Sites-Unnamed_1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
Diammonium Glycyrrhizinate_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0207928
GSE249544,GSE249637_9_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8855_TFPT_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24298
GSE252857_1_v_3_klf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203158_12_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE203158_0_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE139455_4_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.44635
SIX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41038
GSE115542_5_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0724
PL4	DepMap CRISPR Gene Dependency	1.0	2.90053
PMC10830421-41589_2023_1452_MOESM5_ESM.xlsx-HEK293T_MAX-Tg_tissues-Unnamed_0_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
Leigh Disease	DisGeNET Gene-Disease Associations	1.0	null
SKN	DepMap CRISPR Gene Dependency	1.0	2.87472
PMC10055465-media-2.xlsx-ST15-Supplementary_Table_15_Bonferroni-significant_results_of_MAGMA_gene_based_association_analyses_EA_-_p_2_67e-06_0_05_18702_genes_AA_-_p_2_63e-06_0_05_18976_genes_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
B-lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.908
Adipose tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.362
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Organelle inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
PMC12234789-41467_2025_61560_MOESM3_ESM.xlsx-Supplementary_data_1-Only_YY1_IP-MS_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
HEL9217	DepMap CRISPR Gene Dependency	1.0	3.34215
PMC6522222-NIHMS977514-supplement-Sup_Table_15.xlsx-Parental_WT5-Unnamed_0_POU6F2	Rummagene Transcription Factor Associations 2026	1.0	null
decreased hemoglobin content	IMPC Knockout Mouse Phenotypes	1.0	null
GSE157036,GSE166411_3_v_1_halofuginone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DFFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70083
GSE255432_7_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
SAP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1498
9535_UBL7_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.503583
A549_Cerdulatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136462
GSE186739_0_v_1_asic3_human	RummaGEO Gene Perturbation Signatures	1.0	null
MICOS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.564
GSE96991,GSE97117_5_v_1_il11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BALB/3T3-T cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.529
GSE158834_7_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12160862-ijbsv21p3573s2.xlsx-Table_S12-Supplementary_Table_S12_Differentially_Expressed_Genes_in_fibroblast_grouped_by_SOX11_expression_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
GSE179775,GSE198264_0_v_2_ctcf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skeletal muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.441
GSE77795_0_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_11_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_7_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE62843,GSE64371_2_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.8614
Hypothalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.614
GSE169617_1_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE248858_4_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE201042_6_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ATXN7L3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2082
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Major Depressive Disorder	DisGeNET Gene-Disease Associations	1.0	null
GSE217541,GSE217543_0_v_1_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE127970_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.7666
GSE232223_1_v_0_letmd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8410861-41467_2021_25544_MOESM32_ESM.xlsx-MCR-MCR_cells_-_DGE_iGCA_testis_vs_adult_testis_from_GSE112013_and_GSE124263_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Heart Failure	DisGeNET Gene-Disease Associations	1.0	null
Cytotoxic T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.592
PMC7165319-3896263.f6.xlsx-List_of_significantly_diffenent-Significantly_different_proteins_between_AA_pool_and_CON_pool_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
MJ	DepMap CRISPR Gene Dependency	1.0	4.04206
MEL270	DepMap CRISPR Gene Dependency	1.0	3.84398
Prefrontal cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.873
GSE226439,GSE226441_6_v_2_hnf4g_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149901_3_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6724602-mbc-30-1272-s007.xlsx-EGR1_Target_Genes-Gene_ID_s_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12354803-42003_2025_8643_MOESM2_ESM.xlsx-2w_TP63_positive-Gene_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
DIFI	DepMap CRISPR Gene Dependency	1.0	3.42982
2113_DDX24_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.0357
857_BMP2K_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0697
OLFML2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01051
HUPT3_PANCREAS	CCLE Cell Line Proteomics	1.0	2.31372
ICC2	DepMap CRISPR Gene Dependency	1.0	2.9659
GSE234043_0_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC2263127-pone.0001816.s002.xls-Terms_with_Genes_E2F3_up_Bild-Title_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE77178_1_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE219195_0_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Slow muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.218
NSMCE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05698
GSE185519_4_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112860_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EIF2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10304
10244_ZNF260_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.653494
Endocrine pancreas	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.65
RPS6KA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0858
GSE240027,GSE240030_1_v_4_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN2_n_EN2	Rummagene Transcription Factor Associations 2026	1.0	null
GPX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66163
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.8503
RAB11FIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15553
GSE201217_4_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
DMS114_LUNG	CCLE Cell Line Proteomics	1.0	2.50276
8MGBA	DepMap CRISPR Gene Dependency	1.0	2.04815
SCC-15 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.544
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.977969
1943_CTR9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.555925
DBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20381
GSE70935_3_v_5_cyfip1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Glutathione synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.511
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8378
Feeling worry	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.2699
GSE133213_6_v_13_znrf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203158_1_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE95688_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DDX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23744
GSE167218_1_v_0_hoxd12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
Brain - Frontal Cortex (BA9)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.989753
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Leukocyte	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.866
GSE120612_4_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE235390_4_v_0_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211177,GSE211178_8_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE144231_3_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4208_ISG20L2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.23077
GSE168604,GSE183859_1_v_0_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NADH dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.813
7585_RTF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.39062
MDST8_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	4.71509
Integral component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.485
PMC8017594-LSA-2019-00332_Table_S1_Table_12.xls-DCX-KD_LIS1-KD_DEGs-LIS1-KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184795
MAPK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33848
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3601
PIKFYVE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20249
PMC10335698-pone.0285806.s007.xlsx-DMKN-shRNA_KD_Vs_ShSrc-Unnamed_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171837_3_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE201239_0_v_7_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242049_1_v_0_txndc5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE253056_0_v_1_erythropoietin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149123,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2222_DICER1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.510756
PMC9270251-mmc2.xlsx-4_Filtered_DEGs_Control_vs_KD_3-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
7441_RPL17_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.50059
LEPROTL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84002
GSE249544,GSE249637_6_v_2_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Leukemia cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.613
Congestive Heart Failure	DisGeNET Gene-Disease Associations	1.0	null
7585_RTF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.771665
KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	8.15213
decreased circulating serum albumin level	MGI Mouse Phenotype Associations 2023	1.0	null
GSE231891_5_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_2_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_11_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
increased leukocyte cell number	IMPC Knockout Mouse Phenotypes	1.0	null
Limbic system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.614
7577_RSL24D1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.565873
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149264,GSE149267_9_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE93309_5_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ileocecum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.238
PDLIM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47329
GSE242333_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
2567_EIF4E_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.534012
5702_NLE1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.26073
GSE101767_1_v_0_wdr11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.002
GSE125007,GSE125008_6_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217776,GSE217829_2_v_0_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Avian pallium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.839
PMC3419980-leu201249x4.xls-POLII-RUNX1ETO_peaks_2fold-All_gene_regions_having_RUNX1_ETO_peaks_genes_where_PolII_changes_more_than_2-fold_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
Artery - Aorta	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.801841
GSE178227_1_v_2_tet1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142019,GSE142021_1_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Omeprazole_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0166131
PMC10260721-43657_2023_100_MOESM10_ESM.xlsx-MR_for_neuro-traits_FDR_0_05-Gene_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE190950_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190384,GSE190386_1_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE212312_2_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF564	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03634
RH30	DepMap CRISPR Gene Dependency	1.0	2.46767
GSE206870,GSE206872_4_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169590_6_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3043
GSE180641_0_v_1_zfp503_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148262,GSE150691_1_v_2_hdlbp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9529122-pone.0274785.s002.xlsx-S1_Table-S1A_Table_Differentially_expressed_genes_in_HeyA8_overexpressin_ZNF521_vs_HeyA8_control_cells_ZNF521	Rummagene Transcription Factor Associations 2026	1.0	null
K562_PHA-680632_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160354
GSE253041_3_v_0_ramp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_13_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VPS45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55859
PMC11684804-jci-135-174981-s193.xlsx-DESeq2_pseudobulk_AA_Ag_vs_Pre-Gene_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Gandotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134812
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_3_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
A673	DepMap CRISPR Gene Dependency	1.0	3.03994
MCF7_Daphnetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150583
Plantaris muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.616
Fingolimod (hydrochloride)_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.013609
ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1531
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-10q22_1_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
GSE189772,GSE189773_3_v_2_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE179974_3_v_2_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1021
ATAD3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71179
Olfactory lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.454
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.0376
GSE180951_6_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
3677_HEATR1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.08595
PC3	DepMap CRISPR Gene Dependency	1.0	2.92249
Brain - Nucleus accumbens (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.765893
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE212299_3_v_0_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11096100-41588_2024_1714_MOESM3_ESM.xlsx-ST18-Unnamed_1_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
GSE168797_4_v_6_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_9_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE201239_3_v_2_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE179974_3_v_0_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE164874_5_v_10_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Organellar large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.851
6032_PAF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.689645
PMC10679653-mmc2.xlsx-ISL1_KO_Markers_L-Unnamed_0_ISL1	Rummagene Transcription Factor Associations 2026	1.0	null
SNU182	DepMap CRISPR Gene Dependency	1.0	4.13694
GSE221955_3_v_2_igfbp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE133329_2_v_3_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE123836_2_v_3_myf6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213632_1_v_5_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Throat	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.61
GSE125211_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167112
GSE136622_0_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bronchial epithelial cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.989
GSE178907_5_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	1.0	null
SUPT4H1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44226
GSE201042_6_v_10_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE100102_0_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Skeletal muscle fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.124
Erythroid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.566
Corpus striatum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.585
2490_EEF2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.521978
increased blood urea nitrogen level	MGI Mouse Phenotype Associations 2023	1.0	null
GSE165307_3_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE62843,GSE64370_0_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119978,GSE180930_2_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151494_1_v_9_nrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
increased circulating alanine transaminase level	IMPC Knockout Mouse Phenotypes	1.0	null
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
7438_RPL14_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.16854
psn1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.978
MONOMAC1	DepMap CRISPR Gene Dependency	1.0	3.88074
Skeletal system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Lymphoblastic leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.613
GSE126463_5_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Artery - Tibial	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.724225
GSE242083,GSE242098_3_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.989
MCF7_BRD4770_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182448
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DUS1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14056
SNU216	DepMap CRISPR Gene Dependency	1.0	2.4327
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE131660_2_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.441
SNU46	DepMap CRISPR Gene Dependency	1.0	2.81921
TBX20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10253
Bronchial epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.989
7166_RBM25_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.683983
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE197948_2_v_0_atp7b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrial matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.924
PHF19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04331
PMC10663741-mmc4.xlsx-markers_table_FE_ELP_stage-gene_NR5A1	Rummagene Transcription Factor Associations 2026	1.0	null
7451_RPL24_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.4192
TIM22 mitochondrial import inner membrane insertion complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.883
PMC11465086-mmc2.xlsx-Table_ES_1_markers_c0_LPS_Vs_Co-Gene_Expression_Data_1_markers_c0_LPS_Vs_Control_related_to_Figure_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178340_1_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.587863
Nanog	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2161
LLC-PK1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.735
CAD cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.981
Left ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.331
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE143462_0_v_1_omipalisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SMYD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38209
NDUFB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36019
GSE85565_1_v_0_tcf21_human	RummaGEO Gene Perturbation Signatures	-1.0	null
5488_NCAPD3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06425
MCF7_Nintedanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163616
COLO205	DepMap CRISPR Gene Dependency	1.0	3.42445
GSE140322_3_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE60837_2_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
APBB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22403
7458_RPL30_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10776
GSE239578_5_v_6_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mitochondrial membrane	GO Cellular Component Annotations 2025	1.0	null
9242_TRAPPC11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01206
PMC6558497-CAM4-8-3072-s002.xlsx-Table_S4-Table_S4_Hub_JUN_encompassing_genes_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE140576_0_v_2_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9001660-41467_2022_29173_MOESM5_ESM.xlsx-Fig_2g_STAT3_DEGs-gene_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Supplementary_Table_9A_The_effects_of_whole_blood_transcripts_on_COVID-19_severity_with_suggestive_Mendelian_randomization_evidence_P_0_05_using_Genomicc_data_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3264
5770_NPM1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.501738
KELLY	DepMap CRISPR Gene Dependency	1.0	2.01554
PSMD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84095
Fibre tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.681
Mitochondrial tricarboxylic acid cycle enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.097
L33	DepMap CRISPR Gene Dependency	1.0	2.02724
GP5D	DepMap CRISPR Gene Dependency	1.0	3.61921
GSE185944_5_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
1441_CDK7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.21225
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.96367
ZNF426	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19839
Thymus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.573
proton-transporting ATP synthase complex	GO Cellular Component Annotations 2023	1.0	null
Atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.267
4593_LIN52_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.539591
GSE166783_8_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_3_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.890305
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
increased circulating amylase level	IMPC Knockout Mouse Phenotypes	1.0	null
PMC5640240-ppat.1006668.s013.xlsx-MAX_ChIP_shEP400-1-Unnamed_6_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE125219,GSE125221_4_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
5738_NOL9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.647404
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	1.0	3.1872
GSE137325_2_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE155567_1_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164521_0_v_1_nitric oxide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Respiratory epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.989
GSE166783_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
Sonidegib_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0137466
GSE152055_0_v_1_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYBL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4408
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETV5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9165
CCK81	DepMap CRISPR Gene Dependency	1.0	3.15847
GSE234637_3_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Chloroplast ATP synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.964
A549_Vandetanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176644
GSE159937_2_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
4116_INCENP_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.41975
TRMT10C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04937
GSE200839,GSE233826_5_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TBXT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5762
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
4684_LSG1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.16627
GSE244072_10_v_8_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mitochondrial membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
PMC6895612-EMMM-11-e10835-s005.xls-Overlap-Exogenous_circ-CUX1_MS_CUX1	Rummagene Transcription Factor Associations 2026	1.0	null
Pancreatic islet	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.65
7657_SARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.74651
GSE210580_4_v_6_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
t69-brown-adipose_male_8w	MoTrPAC Rat Endurance Exercise Training	-1.0	-2.31569
Brain stem	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.527
Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.7952
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
DNMT3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59269
Inner mitochondrial membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.731
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04973
PMC9314667-Table_1.xlsx-Regulons-TFAP2A_TFAP2A	Rummagene Transcription Factor Associations 2026	1.0	null
Slow twitch muscle fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.344
Hoxd13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.6063
SKNFI	DepMap CRISPR Gene Dependency	1.0	2.43575
GSE147943_2_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE196505,GSE196507_1_v_2_kdm2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8045172-13018_2021_2402_MOESM1_ESM.txt--AA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Peripheral blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.796
Cardiac muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.787
COLO320	DepMap CRISPR Gene Dependency	1.0	3.40553
GSE88819_11_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168797_2_v_3_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_G007-LK_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218735
Cerebral gyrus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.75
7585_RTF1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.61359
GSE178340_7_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8557_STX5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.34411
ATP biosynthetic process	GO Biological Process Annotations 2025	1.0	null
GSE183113_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Lonafarnib_NCI-H2347	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00629815
GSE150072,GSE169209_6_v_9_qser1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7545
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Neurolemma	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.662
3986_HSPE1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.624011
NAPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35926
7480_RPL8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.28191
SNAI2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.313
Olig2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.8727
DIS3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18673
GSE214442_0_v_1_pak4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201042_2_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146982_4_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE218949_0_v_1_cep20_human	RummaGEO Gene Perturbation Signatures	-1.0	null
6851_PSMB3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.573713
LTN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24167
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-4_E2F8-Gene_E2F8	Rummagene Transcription Factor Associations 2026	1.0	null
1841_INTS11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.20001
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.819
Electron transfer flavoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.961
PMC7616765-EMS198548-supplement-Data_S2.xlsx-3_DEG_2D_and_3D-D9_Up_in_2D_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
FOXD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46062
Skeletal muscle	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF407	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92159
Subthalamic nucleus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.565
increased blood urea nitrogen level	IMPC Knockout Mouse Phenotypes	1.0	null
GSE165334_2_v_0_dabrafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216043_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Medulla oblongata	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.629
GSE169356_2_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
9839_WDR74_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.09413
7163_RBM19_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.55743
OS252	DepMap CRISPR Gene Dependency	1.0	3.93133
4371_KIAA1958_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.896318
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.989
2988_FBL_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.29001
PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
mitochondrial membrane	GO Cellular Component Annotations 2023	1.0	null
GSE180789_1_v_0_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199899_3_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PCDHB13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16351
PMC9307901-mmc2.xlsx-S5-GATA6-AS1_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
Basal ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.839
GSE158834_10_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mitochondrial inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	1.0	null
decreased hemoglobin content	MGI Mouse Phenotype Associations 2023	1.0	null
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5166
PBXIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27615
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HNF4G	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4385
HOMEZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03617
GSE112763,GSE112767_4_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Heart - Atrial Appendage	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.910912
NB17	DepMap CRISPR Gene Dependency	1.0	2.52538
GSE201239_6_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_Regorafenib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164663
Hoxa13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.0501
GSE119978,GSE180930_3_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
dolichol-phosphate-mannose synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.548
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135030_3_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Left atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.226
J82	DepMap CRISPR Gene Dependency	1.0	4.10375
GSE133213_6_v_5_znrf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZSCAN21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0106
MPDU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68257
697	DepMap CRISPR Gene Dependency	1.0	2.16078
3988_HSPH1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10523
8669_TAF7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.502677
ABAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46093
GSE209938_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.839
Integral component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.484
GSE155567_3_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pyruvate kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.627
311 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.618
GSE150215_1_v_2_etl4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112860_9_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Parenchyma	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.624
Caudate nucleus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.585
GSE110178_5_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TIM23 mitochondrial import inner membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.142
PMC5640240-ppat.1006668.s013.xlsx-BETA4-379_common_elements_in_shEP400-1_BETA_shEP400-3_BETA_shMYCL_BETA_and_shEP400-2_BETA_BHLHE23	Rummagene Transcription Factor Associations 2026	1.0	null
Blood	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE77178_6_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
9250_TRAPPC5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10423
increased neutrophil cell number	MGI Mouse Phenotype Associations 2023	1.0	null
GSE239844_11_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6345883-41598_2018_37397_MOESM10_ESM.xlsx-AR_D0_VS_D14__TRANS-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SPATA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30381
PMC10898050-12967_2024_4947_MOESM2_ESM.xlsx-Table_S7-Table_S7_Differentially_expressed_genes_between_the_TCF7_CD8_memory_T_cells_and_the_other_memory_CD8_T_cells_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146074_1_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE110580_1_v_0_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE227592_9_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE249544,GSE249637_9_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_11_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11563688-jci-134-173448-s017.xlsx-EC2-gene_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
GSE102870_3_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7479_RPL7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.29725
8658_TAF1C_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.13729
LS411N	DepMap CRISPR Gene Dependency	1.0	3.08654
PMC11385366-Table2.xlsx-DBP-Overlapped_Gene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213715_0_v_1_iqgap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE231641_0_v_1_robo1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_TGX-221_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153238
increased circulating phosphate level	MGI Mouse Phenotype Associations 2023	1.0	null
2225_UTP25_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.09864
Neostriatum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.585
GSE136622_7_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE252857_1_v_3_prednisone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
9629_ATP5MD_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-1.23438
PMC7165319-3896263.f6.xlsx-List_of_AA_outlier_pool-AA_outlier_pool_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239541_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE161825_1_v_0_tipranavir_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Right atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.267
GSE215351,GSE215794_4_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Chloroplast thylakoid membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.559
GSE137914_4_v_1_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_8_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11462941-CAS-115-2947-s001.pdf-88-SOX21_SOX21	Rummagene Transcription Factor Associations 2026	1.0	null
SIPA1L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45924
GSE205163,GSE205164_2_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
Trunk	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.61
Superoxide dismutase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.788
9653_USP37_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.02145
GSE225447_1_v_0_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
2918_FAM32A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05923
Lymphocytic leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.613
GSE190384,GSE190386_2_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
increased monocyte cell number	MGI Mouse Phenotype Associations 2023	1.0	null
Metabolism	Reactome Pathways 2024	1.0	null
PMC10746608-427_2023_709_MOESM5_ESM.xlsx-SOX2_partners-SOX2_known_protein_partners_according_to_BioGrid_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE93674_2_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE222758_0_v_3_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Midbrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.681
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.6367
4314_KDELR1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.700835
GTEx Muscle 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-6.08372
Hematopoietic cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.613
GSE218907_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cybrid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.783
PATU8988T	DepMap CRISPR Gene Dependency	1.0	2.82723
Intrinsic component of organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.445
K562_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161333
GSE210885_2_v_4_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE200673,GSE200691_2_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
CPLANE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20243
GSE200352_5_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8403
GSE158456_1_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
5737_NOL8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.20747
NCIH2110	DepMap CRISPR Gene Dependency	1.0	2.10825
PMC7430827-12864_2020_6933_MOESM4_ESM.xlsx-Sheet1-Additional_file_4_Table_S4_A_list_of_3_062_genes_containing_locus_where_only_KD_had_non-synonymous_SNPs_compared_to_other_duck_breeds_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10864182-41588_2023_1596_MOESM4_ESM.xlsx-ST12_Significant_Genes_combine-Supplementary_Table_12_Genes_prioritisation_combining_FUMA_MAGMA_Hi-C_MAGMA_and_TWAS_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160001,GSE160670_3_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE68155_3_v_2_gpr3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10864182-41588_2023_1596_MOESM4_ESM.xlsx-ST12_Significant_Genes_combine-Unnamed_1_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11161988-12906_2024_4523_MOESM3_ESM.pdf-82-IRX3_IRX3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239844_11_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Blood cancer cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.613
GSE205163,GSE205164_5_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
CIR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1798
Mitochondrial permeability transition pore complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.372
PMC6469946-aav1472_Data_file_S3.xlsx-PPARG_targets_UP_RNA-Seq_Young-Supplemental_Table_3_PPARG_targets_up_regulated_in_dKO_vs_CONTROL_RNA-Seq_Young_FDR_0_1_n_376_PPARG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158456_2_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
7443_RPL18_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.15072
vincristine_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.013869
Unipolar Depression	DisGeNET Gene-Disease Associations	1.0	null
Sonidegib_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0119029
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-GM12878_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Olfactory bulb	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.454
GSE95685_6_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Prednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142816
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
increased circulating amylase level	MGI Mouse Phenotype Associations 2023	1.0	null
Connective tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.362
GSE200839,GSE233826_2_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
COPRS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08386
GSE112761,GSE112767_2_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_10_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11143203-41422_2024_945_MOESM14_ESM.pdf-79-CREM_CREM	Rummagene Transcription Factor Associations 2026	1.0	null
7657_SARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.965471
Terfenadine_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0170242
USP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27037
GSE140074_1_v_0_kif20a_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160001,GSE160670_1_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE120612_6_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE144838_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Omeprazole_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00904802
6980_PYURF_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.76568
K562_Carmofur_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0225519
GSE135350_3_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
3632_HARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.508414
GSE151090_0_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pons	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.476
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3741
Organellar ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.549
Morula cell (Blastomere)_Embryo_Human	CellMarker Gene-Cell Type Associations	1.0	null
ZBTB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7782
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6357
Bone marrow	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.313
PMC6138936-13059_2018_1512_MOESM2_ESM.xlsx-SE_H1-_MSC-Gene-symbol_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
C80	DepMap CRISPR Gene Dependency	1.0	4.1318
Skeletal system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.441
Biceps femoris	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.066
Leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.613
3871_HNRNPL_P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.664553
7431_RPL10A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10181
GSE193177_1_v_3_st266_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MICA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48994
decreased circulating glucose level	MGI Mouse Phenotype Associations 2023	1.0	null
Plant vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.712
496100395_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.07791
GSE171724_4_v_6_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Estrone sulfate (potassium)_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0156613
Integument	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.702
GSE115542_2_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE250534_0_v_3_cabergoline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Mitochondrial large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.857
GSE240439_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cerebellum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.487
PA1	DepMap CRISPR Gene Dependency	1.0	3.39447
GSE247862,GSE247863_4_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147056_4_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3635
BTBD17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55808
Cardiac muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.434
GSE158834_11_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE75976_3_v_4_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7233
Adrenal cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.554
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE152055_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.623
PMC11079006-41467_2024_48118_MOESM7_ESM.xlsx-E2F6_OE_vs_EGFP_CTR_DE-gene_E2F6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193993_5_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114013,GSE114014_1_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pancreatic beta cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.573
Hair shaft	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.814
Respiratory chain complex I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.83
A549_BMS-265246_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0113742
PMC10679653-mmc4.xlsx-ISL1_KO_Markers_T_L-Unnamed_0_ISL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DMRT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10209
PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_spleen-Unnamed_1_RAG1	Rummagene Transcription Factor Associations 2026	1.0	null
CAL33	DepMap CRISPR Gene Dependency	1.0	2.59753
increased leukocyte cell number	MGI Mouse Phenotype Associations 2023	1.0	null
ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9662
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7803
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE42805,GSE42811_1_v_0_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MRPS30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09602
GSE131377_4_v_2_spocd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
8744_TBRG4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.21275
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9357
NCIH1092	DepMap CRISPR Gene Dependency	1.0	2.12945
E2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2183
GSE228106_3_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NR1I2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2436
ATP5MK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21002
GSE227592_0_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GBA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48598
Stomach	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.585
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
decreased circulating serum albumin level	IMPC Knockout Mouse Phenotypes	1.0	null
COA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82617
4908_MCOLN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.779893
GSE240027,GSE240030_5_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE136622_2_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Spleen	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.392
6629_PPIL1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.665182
PMC3376834-emmm0004-0052-SD2.xlsx-NR2E3_Specific_1847-Unnamed_1_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
Plastid thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.503
NCIH1755	DepMap CRISPR Gene Dependency	1.0	2.17396
K562_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189445
GSE149264,GSE149267_4_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Temporal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.709
GSE114690_2_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE100217_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_TMP195_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140293
PMC2263127-pone.0001816.s001.xls-E2F3_up_Bild-Symbol_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
MPV17L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08514
GSE62292,GSE62295_2_v_0_col4a3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210655_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
5860_NUDCD3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.518385
GSE220942_2_v_1_galnt7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE134191_3_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Cecum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.238
Foxo3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.3942
PMC8363470-mmc4.xlsx-Strategy_3-KD_CoV-2-_vs_CTL_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Mitochondrial respiratory chain complex IV	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.744
KMS20	DepMap CRISPR Gene Dependency	1.0	3.5658
GSE63048_11_v_8_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158301
GSE210101,GSE210114_0_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
METAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43007
mitochondrial proton-transporting ATP synthase complex	GO Cellular Component Annotations 2023	1.0	null
GSE87404,GSE87812_1_v_3_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Intrinsic component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.614
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
6536_POLR1C_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10336
Acute lymphoblastic leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.613
7433_RPL11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.17422
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HS294T_SKIN	CCLE Cell Line Proteomics	1.0	4.95688
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TEAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7546
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.989
343_ANKRD52_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.531491
GSE211151_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
decreased circulating total protein level	MGI Mouse Phenotype Associations 2023	1.0	null
PANO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81654
9175_TOP2A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.549429
Methylthiouracil_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0133095
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
9629_ATP5MD_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.70612
Response to citalopram or escitalopram in depression	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.639794
Entecavir (monohydrate)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0141178
PMC8566473-41467_2021_26653_MOESM3_ESM.xlsx-SOX2_interacting_proteins-Gene_symbol_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
ATP biosynthetic process	GO Biological Process Annotations 2023	1.0	null
Organellar small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.835
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112761,GSE112767_4_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE134375_6_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
9482_UBA52_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.50682
WDR83OS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02033
GSE158834_11_v_5_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
proton-transporting ATP synthase complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
HCC1937_BREAST	CCLE Cell Line Proteomics	1.0	2.59803
NCIN87	DepMap CRISPR Gene Dependency	1.0	3.74208
TFEC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5687
GSE249544,GSE249637_6_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4909989-ncomms11840-s2.xlsx-up-regulate-The_YAP_TEAD4-FL_YAP_TEAD4-S_and_YAP_RBM4_regulated_genes_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
Thalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.771
GSE208254_4_v_5_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RCC10RGB	DepMap CRISPR Gene Dependency	1.0	3.12327
Cerebral peduncle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.681
PMC9904760-elife-79363-supp2.xlsx-MDS1-Gene_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
GSE84922,GSE84924_4_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
9210_TPP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.583188
i-AAA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.534
5339_MTOR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.507813
H3118	DepMap CRISPR Gene Dependency	1.0	3.21535
INA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.164
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.507648
PMC11166884-mmc4.xlsx-Table_S3-Table_S3_proinflammatory-EC2_comparison_between_WT_and_TG_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal gait	IMPC Knockout Mouse Phenotypes	1.0	null
7466_RPL36_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.519881
Rucaparib (phosphate)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0116573
increased mean corpuscular volume	MGI Mouse Phenotype Associations 2023	1.0	null
OE-33 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.768
ASPC1	DepMap CRISPR Gene Dependency	1.0	2.22947
GSE171837_0_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_U87MG_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PGR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01946
GSE200320_3_v_2_mfge8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EM2	DepMap CRISPR Gene Dependency	1.0	2.22039
K562_Busulfan_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181285
GSE125862_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
MRTFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28841
SKCO1_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	3.23342
Lymph node	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.796
EXOC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14793
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE133213_11_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160817_3_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_8_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DDX23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23791
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GLMP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14511
BAY1125976_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0182307
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lymphoblast	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE168797_2_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
4271_KANSL2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.23522
Lymphoid tissue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Neck	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.61
CMLT1	DepMap CRISPR Gene Dependency	1.0	2.86422
MCF7_Gandotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192214
Brain - Caudate (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.671937
GSE139455_7_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Sertoli cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
3869_HNRNPK_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.50214
GSE200320_1_v_0_mfge8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9314667-Table_1.xlsx-Regulons-MITF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
HSC39	DepMap CRISPR Gene Dependency	1.0	2.94157
496100326_TCx_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01337
TC205	DepMap CRISPR Gene Dependency	1.0	2.1948
GSE202434,GSE202438_2_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
5588_NEDD8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.596957
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4704
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE143994_2_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Oxoglutarate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.643
9687_UTP6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24749
PMC4113144-1476-4598-13-64-S5.xls-IRF1_exon_good-Unnamed_1_IRF1	Rummagene Transcription Factor Associations 2026	1.0	null
1961_CUL2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.08973
Cingulate gyrus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.75
Diabetes	DisGeNET Gene-Disease Associations	1.0	null
MOLT-4 cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.613
GSE146840,GSE146842_3_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	1.0	null
8040_SLC35A4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03152
Response to cognitive-behavioural therapy in major depressive disorder	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.569897
GSE111035,GSE111040_8_v_5_plag1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CALU6_LUNG	CCLE Cell Line Proteomics	1.0	8.14118
Mitochondrial crista	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.827
Cardiomyocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.881
GSE140322_3_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE200352_9_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Aurora A Inhibitor I_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155551
GSE215155_0_v_1_golph3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE231648_1_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE121043_0_v_1_aldh1a1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.89498
Globus pallidus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.397
1771_COPB1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.28461
GSE171837_0_v_3_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
D423MG	DepMap CRISPR Gene Dependency	1.0	4.28005
HCT116	DepMap CRISPR Gene Dependency	1.0	2.43926
Mitochondrial biogenesis	Reactome Pathways 2024	1.0	null
Lymphoid cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE166308_1_v_0_pim1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DYNC1LI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44952
GSE169697,GSE169725_0_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
COLO680N	DepMap CRISPR Gene Dependency	1.0	2.57996
GSE128730_7_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
increased circulating phosphate level	IMPC Knockout Mouse Phenotypes	1.0	null
K562_Pelitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178821
KYM1	DepMap CRISPR Gene Dependency	1.0	2.36025
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.04
496100494_HIP_no dementia_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.18622
PMC7397849-supp_gad.338681.120_Supplemental_Table_S1.xlsx-S1L_Shared_genes_3way_overlap-Suppl_Table_S1L_Shared_genes_between_YAP1-MAMLD1_YAP1-FAM118B_YAP1-TFE3_in_vitro_human_samples_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
SUM185PE	DepMap CRISPR Gene Dependency	1.0	2.13402
Brain - Substantia nigra	GTEx Tissue Gene Expression Profiles 2023	1.0	2.16635
CCLP-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.802
GSE111138,GSE111149_1_v_0_runx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE240027,GSE240030_1_v_0_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Biceps	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.849
Dihydrolipoyl dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.2
A549_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01376
PRELID3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14629
TC138	DepMap CRISPR Gene Dependency	1.0	4.36437
Lung	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.598406
Lymphocyte	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE183335,GSE183351_3_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
THRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.2802
MPP89	DepMap CRISPR Gene Dependency	1.0	2.79461
PACADD188	DepMap CRISPR Gene Dependency	1.0	2.67791
MCFD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14584
decreased circulating total protein level	IMPC Knockout Mouse Phenotypes	1.0	null
GSE202434,GSE202438_6_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Tcf21	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.3545
5869_NUDT21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.625163
PMC9270251-mmc2.xlsx-2_Filtered_DEGs_Control_vs_KD_2-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CHLA90	DepMap CRISPR Gene Dependency	1.0	2.5155
GSE199204,GSE211619_4_v_2_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
increased circulating aspartate transaminase level	IMPC Knockout Mouse Phenotypes	1.0	null
GSE239578_0_v_4_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Clonidine (hydrochloride)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.014519
GSE215086_8_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11282827-40659_2024_524_MOESM5_ESM.xlsx-PRRX1-sequence_name_PRRX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE95685_2_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
9248_TRAPPC3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.07302
ENPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15637
PSS008	DepMap CRISPR Gene Dependency	1.0	3.27405
GSE199874_4_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248858_1_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Brain - Hippocampus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.03142
Exocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.515
GSE158834_10_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.75198
PMC4634137-ncomms9549-s7.xlsx-ZF_Hair_cell_data-Unnamed_1_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6347712-pnas.1812449116.sd04.xlsx-Differential_IRF7_to_GFP-ID_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
Occipital lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.727
GSE249544,GSE249637_6_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Tolmetin_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0154835
Mitochondrial envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
CNOT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03104
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE147943_7_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165548_2_v_8_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE222445_2_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
4950_MED27_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.3607
Hindbrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.527
Thyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.61
OVMIU	DepMap CRISPR Gene Dependency	1.0	2.8776
SET2	DepMap CRISPR Gene Dependency	1.0	2.25161
GSE202434,GSE202438_3_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Lapatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146833
GSE143662_3_v_1_dcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_10_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE136742,GSE136744_0_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18563
GSE232624_4_v_5_ethanol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205316,GSE205317_0_v_1_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Clopidogrel_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00745488
ZNF382	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9969
GSE203158_5_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10618
6798_PRPF40A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.663612
8605_SURF6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.1155
Pitavastatin (Calcium)_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0146753
CHCHD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07146
GSE158853_0_v_1_hmgcs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE154219_0_v_2_cholestyramine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
8288_SOX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.868748
OSR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6896
HDQP1_BREAST	CCLE Cell Line Proteomics	1.0	2.92241
GSE98898_7_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147662_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE201042_6_v_1_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Vertebrate muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE193177_1_v_2_st266_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211286_7_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Sperm midpiece	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.974
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110178_5_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_7_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6071_PARK7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.784548
PMC3607232-mmc3.xlsx-a_RUNX1_SEM_MLLN_AF4C_H3K79Me-x_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_11_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08047
GSE191105_2_v_4_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL2-Unnamed_0_TAL2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8755441-mmc3.xlsx-IRF7-Up-IRF7Del246-647_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
ACSL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37615
GSE124932_2_v_1_sarm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
increased circulating alanine transaminase level	MGI Mouse Phenotype Associations 2023	1.0	null
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
9_AAR2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.11554
PMC12396377-jcb_202307079_tables1.xlsx-Fig_1C_i_-_iii_right-x_TFEB_KOcon_VS_WTcon_UP_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE190384,GSE190386_3_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
mitochondrial inner membrane	GO Cellular Component Annotations 2025	1.0	null
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE158834_10_v_6_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6345883-41598_2018_37397_MOESM10_ESM.xlsx-AR_D0_VS_D7_W_B29__TRANS-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4805
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.629926
MCF7_Meprednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182529
GSE208254_3_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Tonsil	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.508
Methylthiouracil_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00662967
5902_NUP88_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.538293
Mitochondrial complex 5	ClinVar Gene-Phenotype Associations 2025	1.0	null
Embryonic brain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.565
SRRM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9644
PRKX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12582
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE84922,GSE84924_0_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mitochondrial alpha-ketoglutarate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.438
GSE154767_2_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE189336_1_v_0_nitric oxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S27_LF_C2_24h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
HGC27	DepMap CRISPR Gene Dependency	1.0	2.02918
proton-transporting two-sector ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.393
GSE135312_1_v_2_bmpr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Fulvestrant_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0105679
PMC6605752-JEM_20181726_TableS1.xlsx-MYC_translational_targets-Unnamed_1_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FRAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.046
GSE203158_5_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE238116_1_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197868
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Mitochondrial iron-sulfur cluster assembly complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.64
ING3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71508
GSE156454_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178340_1_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cingulate cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.75
NCIH441_LUNG	CCLE Cell Line Proteomics	1.0	3.08279
PMC6319725-pone.0204197.s006.xlsx-Table_S2-S2_TABLE_-_Operon_Expression_and_SOM_clustering_data_for_Gene_Set_identified_by_ANOVA_p_0_005_1005_genes_FDR_8_8_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
LSM8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12476
GSE138945,GSE138947_0_v_1_mboat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190384,GSE190386_6_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149035_3_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7000220-elife-50163-fig3-data1.xlsx-genes_SOM_xls-gene_symbol_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
TCF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2557
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
fh1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.693
Ahr::Arnt	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.625
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4896
MEOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1368
Lymphoblastoid cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.613
GSE62843,GSE64371_2_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.585214
GSE245270_2_v_0_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
sc71	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.857
CLK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18325
MKS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05264
RMUGS	DepMap CRISPR Gene Dependency	1.0	2.31621
K562_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219117
Mouth	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.515
SKNMC	DepMap CRISPR Gene Dependency	1.0	2.86687
GSE100863,GSE100864_3_v_0_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KXD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08307
NCAPH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91749
CBY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63718
GSE112763,GSE112767_2_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235596_0_v_1_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12271601-mmc2.xlsx-OUT_cells_02-Gene_Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
GSE179880_7_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.744687
RAX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02401
2203_DHX15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.525496
Pineal gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.93
increased neutrophil cell number	IMPC Knockout Mouse Phenotypes	1.0	null
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3545
LS	DepMap CRISPR Gene Dependency	1.0	2.643
Brain - Cerebellar Hemisphere	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.13273
GSE200673,GSE200691_1_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
3677_HEATR1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.602817
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Tazemetostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147737
PMC13000489-mmc1.xlsx-Table_S3-Table_S3_LC_related_genes_screened_by_MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
RIDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08656
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
5903_NUP93_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.94471
GSE114258_1_v_0_foxk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147283_1_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
9253_TRAPPC8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.2932
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.64705
E2F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1301
PLEKHO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35395
t69-brown-adipose_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.02645
GSE207282_1_v_0_polydatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
106_ACTL6A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.573793
SOHLH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0531
2852_FAM133B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.52514
PMC3419980-leu201249x4.xls-H3K9Ac-RUNX1ETO_peaks_2fold-All_gene_regions_overlapping_with_RUNX1-ETO_peaks_changing_histone_acetylation_more_than_2-fold_after_knock-down_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7923339-13046_2021_1884_MOESM7_ESM.xlsx-Overlap-3_UTR_lengthened_genes_in_CPSF6_KD_Huh7_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
127399	DepMap CRISPR Gene Dependency	1.0	3.2906
3436_RACK1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.502753
NUP37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2639
GSE129465_3_v_2_phf6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Formation of ATP by chemiosmotic coupling	Reactome Pathways 2024	1.0	null
GSE149880_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
proton motive force-driven ATP synthesis	GO Biological Process Annotations 2025	1.0	null
Auranofin_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0140328
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_U87MG_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Lymphoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.615
A549_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151743
increased monocyte cell number	IMPC Knockout Mouse Phenotypes	1.0	null
GSE112763,GSE112767_2_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ABL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05442
GSE112860_5_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Parietal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.631
CBLL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35515
ETF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14336
GSE159446,GSE159449_1_v_0_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Amygdala	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.839
Mitochondrial ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.559
Immune system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE158834_10_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2775
CBX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3143
Muscle	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Respiratory chain complex III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.595
GSE193999,GSE194000_3_v_2_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Respirasome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.878
PMC11141901-jciinsight-9-166505-s172.pdf-18-FOXP1_FOXP1	Rummagene Transcription Factor Associations 2026	1.0	null
Thorax	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.573
PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Unnamed_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.5095
PMC10243915-uxad037_suppl_supplementary_table_s1a.pdf-115-ZNF776_ZNF776	Rummagene Transcription Factor Associations 2026	1.0	null
7479_RPL7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.548332
GSE84462,GSE84762_0_v_7_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE166004_5_v_6_pld1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CREB3L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29979
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11079006-41467_2024_48118_MOESM7_ESM.xlsx-ZNF274_OE_vs_EGFP_CTR_DE-gene_ZNF274	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184892_7_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12721900-jci-136-187998-s161.xlsx-Flag-ETS1_vs_vector-Gene_ETS1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE62843,GSE64371_4_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Mitochondrial prohibitin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.001
Vertebrate muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.441
6871_PSMD3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.500394
K562_Avagacestat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150418
PLEKHN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03837
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PCDH10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59314
PMC13127299-mmc2.xlsx-PBX1_kdRNAseq-hgnc_symbol_PBX1	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate gland epithelium	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE213228_4_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
5587_NEDD8-MDP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.13141
2977_FASTKD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.524715
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118077_1_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.2222
13_AARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.52126
GSE71491_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE211286_1_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.30127
PMC6605752-JEM_20181726_TableS1.xlsx-MYC_translational_targets-Table_S1_Lists_of_translational_targets_of_MYC_in_MYC_ON_vs_MYC_OFF_P493_cells_and_their_5_UTR_sequences_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Busulfan_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148867
SALL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36852
GSE161846,GSE161849_4_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE71385_1_v_0_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112763,GSE112767_2_v_5_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213228_1_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Mitochondrial crista junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.577
PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN1_n_EN1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H2AC16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29237
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6466
GSE239844_6_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ROVA cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.523
GSE154081_3_v_0_sildenafil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FEV	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7115
6558_POLR3D_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06471
GSE104508_2_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.564
PMC3853418-1756-8935-6-34-S3.pdf-6-ZNF415_ZNF415	Rummagene Transcription Factor Associations 2026	1.0	null
GSE214823,GSE214824_0_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
2622_EMG1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.14864
Cristae formation	Reactome Pathways 2024	1.0	null
Salivary gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.515
Mitochondrial small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.835
GSE202434,GSE202438_6_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.27283
GSE205163,GSE205164_5_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
1365_CD3EAP_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.13659
4959_MED9_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03141
GSE104022_1_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SAOS2	DepMap CRISPR Gene Dependency	1.0	2.23178
PMC5263239-mmc2.xls-SEM_wt_MLL-Gene_name_1614_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166004_5_v_4_pld1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248858_4_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
proton motive force-driven ATP synthesis	GO Biological Process Annotations 2023	1.0	null
GSE178340_5_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.985
Lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.908
Metencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.487
COLO684	DepMap CRISPR Gene Dependency	1.0	2.55673
GSE145249_1_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00609
GSE239844_8_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_11_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PHLDA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23461
Heart ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.331
PMC8208823-mmc2.xlsx-CDX2-KO_mesenchymal_DEG-feature_CDX2	Rummagene Transcription Factor Associations 2026	1.0	null
RH41_SOFT_TISSUE	CCLE Cell Line Proteomics	1.0	2.44979
Mitochondrial proton-transporting ATP synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.955
MSANTD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0643
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
7468_RPL37_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.1409
TMED2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53048
HNF4A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.6724
Fenofibrate_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0105113
GSE191105_2_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE240030,GSE252532_0_v_2_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157557,GSE157559_1_v_0_parp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125007,GSE125008_10_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
6740_PREB_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12206
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim29_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Collecting duct intercalated cell_Kidney_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11399095-44161_2024_532_MOESM7_ESM.xlsx-Sheet1-Supplementary_Table_6_DEG_of_hyperexpanded_clones_in_EAT_vs_AA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
2568_EIF4G1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.541741
GSE109913_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_2_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217541,GSE217543_0_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Epithelium	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Myelencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.629
496100478_HIP_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.03477
HCC1419	DepMap CRISPR Gene Dependency	1.0	2.53271
GSE214596,GSE214598_1_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Pexidartinib (hydrochloride)_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0149592
GSE112763,GSE112767_0_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Methylprednisolone succinate_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00632757
PMC3296722-pone.0032481.s009.xlsx-Sheet_1_MSC_vs_references-Gene_Symbol_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
ACSM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98548
Vagina	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.533862
3583_GTF3A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.84286
6537_POLR1D_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.16167
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mitotic fetal germ cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
Metallochaperone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.018
NR1D1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.0357
K562_Hesperadin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151542
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
proton-transporting two-sector ATPase complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE228106_0_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RNF113A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45081
GSE182835,GSE182836_0_v_1_siah2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE100102_0_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ETV3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0435
ITSN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53646
GSE147613_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
7251_RFFL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.937033
GSE244233_1_v_0_quercetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210655_3_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
B-lymphoblastoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.908
GSE179974_3_v_4_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.399
PMC12396377-jcb_202307079_tables1.xlsx-Fig_1C_i_-_iii_right-y_TFEB_KO_LLOMe_VS_WTLLOMe_UP_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE150669_0_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_6_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nucleus lentiformis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.397
abnormal gait	MGI Mouse Phenotype Associations 2023	1.0	null
K562_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160755
ST13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56858
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
increased mean corpuscular volume	IMPC Knockout Mouse Phenotypes	1.0	null
7475_RPL5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.5384
GSE240027,GSE240030_5_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227592_10_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6025
PMC8764619-mmc7.xlsx-supplementary_table_for_the_Ven-GSE131737_TFAP2B_target_genes_G_gallus_1347_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
Sivelestat (sodium tetrahydrate)_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00923876
1458_CDT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.627253
PMC8355885-gutjnl-2020-320652supp004.xlsx-RALY_KD_mRNA-seq-Table_3_RALY_Knockdown_in_HCT116_cells_mRNA-seq_log2_FC_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
7471_RPL39_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.18907
MCF7_SRT2104_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145491
GSE202284,GSE202289_1_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE183271_2_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2307_DNASE1L1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.501021
Econazole_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00660269
GSE105170,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Streptozotocin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154958
TXNL4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34297
1605_CHTF8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.09538
CUL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40431
Esophagus - Muscularis	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.21647
Artery - Coronary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.06737
GSE183251_1_v_3_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE92364_1_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_0_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE156923_2_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_PD173074_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178711
RHEBL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10159