association	dataset	threshold value	standardized value
NR3C2-34362910-WISTARRAT-HIPPOCAMPUS-STRESS	ChEA Transcription Factor Targets 2022	1.0	null
VAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.296
VZ in subgenual cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.39165
Neuron projection	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE214212_2_v_1_chd6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE189941_1_v_2_kdm4c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ammonium transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.977
endoplasmic reticulum-Golgi intermediate compartment membrane	GO Cellular Component Annotations 2025	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.937943
Mafg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.1142
GSE65617_2_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157777_2_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COX5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50529
UA-39-TN76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.703638
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.871003
RP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.53666
LMNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25907
regulation of polyamine transmembrane transport	GO Biological Process Annotations 2015	1.0	null
RAB39A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91678
Allantoic fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.01
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE149903_5_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05256
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.3973
NUDT19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59533
TAF1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3456
MCIXC	DepMap CRISPR Gene Dependency	1.0	5.28285
ETV5::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.3697
GSE158834_1_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Anaplasia	DisGeNET Gene-Disease Associations	1.0	null
SK-N-AS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-1207-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.911801
CRCGN015_MCF10A_48H:M06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12404
posteroventral (inferior) parietal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.927451
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8339
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.092
GSE67266_7_v_4_etoposide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.619
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.6262
CRCGN015_MCF10A.TP53.M_24H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2345
orbital frontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.975182
Meningioma, Benign, No Icd-O Subtype	DisGeNET Gene-Disease Associations	1.0	null
GSE182680,GSE182683_0_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pituicyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.717
GSE114284_4_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE100316_5_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE96777,GSE96778_1_v_0_zbtb4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Global Developmental Delay	DisGeNET Gene-Disease Associations	1.0	null
CDX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5505
JIMT-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.62
STAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16191
GSE227415_1_v_0_ucp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE98964_0_v_2_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_4_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE184356_1_v_2_tfam_human	RummaGEO Gene Perturbation Signatures	1.0	null
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.358036
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20027
FYTTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66816
Limb-Mammary Syndrome	DisGeNET Gene-Disease Associations	1.0	null
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.18514
VB-89-RG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20916
CHRNA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84584
MOB3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.56753
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.382874
PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-DMOG_-_HIF1A-gene_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
Nerve plexus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.636
Photosystem	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.479
Neuronal cell body	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE87404,GSE87812_2_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02249
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GALNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56656
GSE224969,GSE224971_0_v_5_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157960_2_v_3_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ACOT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.40562
DAZAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26481
GSE235701,GSE261434_0_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE196699_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE164874_5_v_12_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AURKA_knockdown_89_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.33378
GSE144443_0_v_6_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PTRH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19992
dendrite	GO Cellular Component Annotations 2023	1.0	null
RIOK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4741
HAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3218
KG-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07455
GSE178255_3_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
bsc1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.691
Hemorrhage	DisGeNET Gene-Disease Associations	1.0	null
GSE188870,GSE188871_4_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
bone marrow	HPA Tissue Protein Expression Profiles	-1.0	-1.17543
Adenoid cystic carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.848
GSE118794_5_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157894_2_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04337
Corpus luteum cyst	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.428
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.85734
GSE119978,GSE180930_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9169777-pnas.2120787119.sd07.xlsx-Sheet1-Dataset_S7_Significantly_differentially_expressed_genes_between_G2_and_GATA3_WT_T-ALL_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
mostly	GeneRIF Biological Term Annotations	1.0	null
GSE223893_4_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAGEE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26807
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.155
GSE205976,GSE205978_2_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202744_1_v_3_toyocamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.937418
6071_PARK7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.67156
Epimastigote	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.395
decreased circulating insulin level	MPO Gene-Phenotype Associations	1.0	null
HAUS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.59
PMC10534007-Table_2.xlsx-S3_unique_up_MSC_V-817_elements_included_exclusively_in_VM-CUB1_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
UM-UC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04236
agmatine biosynthetic process	GO Biological Process Annotations 2023	1.0	null
ROMO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91905
IGDCC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41634
GSE242199_9_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3M_Peaks_YAP1MAMLD1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
CHP126	CCLE Cell Line Gene CNV Profiles	-1.0	-2.20765
DMS153	CCLE Cell Line Gene CNV Profiles	1.0	1.64283
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.898223
interleukin-1 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.039
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC33	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.898223
SLC41A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57976
KLRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31664
NCI-H526 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.617
PPP1R14B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40315
GATA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0488
GSE172295_4_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.427131
PMC9894241-pnas.2211429119.sd05.xlsx-G7_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05166
OAW28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.868636
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148066,GSE157787_9_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of protein catabolic process	GO Biological Process Annotations 2015	1.0	null
NOL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50559
SNU-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.893833
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04236
GSE196117_6_v_7_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158202
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE214442_0_v_1_pak4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ETS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3094
GSE217452_3_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211286_4_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8052
E2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0042
GSE240027,GSE240030_1_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3K_Peaks_wtYAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
ATP1B3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66956
serves	GeneRIF Biological Term Annotations	1.0	null
trans-golgi network membrane organization	GO Biological Process Annotations 2015	1.0	null
Autonomic nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
GSE57871_6_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5474565-onc2016488x2.xlsx-Table_S4_MLL_Target_Genes-MV4-11_MLL-AF4_target_genes_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
PSN1	DepMap CRISPR Gene Dependency	1.0	2.76344
RASAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.4037
GSE135686_2_v_3_etomoxir_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE175787_4_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.221
cis-golgi network	GO Cellular Component Annotations 2015	1.0	null
GSE172189_0_v_1_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12513837-41588_2025_2336_MOESM4_ESM.xlsx-Supplementary_Table_1-Supplementary_Table_1_List_of_AR-only_and_p300_AR-shared_enhancer_regulated_genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Epithelioma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Hippocampus minor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.704
regulation of protein catabolic process	GO Biological Process Annotations 2023	1.0	null
ZNF213	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	86.163
GSE202434,GSE202438_9_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pollen tube	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.982
SNRPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23911
GSE172016_2_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178532_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151612_4_v_10_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
UACC-257	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.35564
GPKOW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03336
PTEN_KD_GDS2958_101_human_SKBR-3 MAMMARY ADENOCARCINOMA cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE226439,GSE226441_6_v_2_hnf4g_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66832
Autoimmune disease of the nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.87
Colitis	DisGeNET Gene-Disease Associations	1.0	null
PMC9509360-41419_2022_5262_MOESM6_ESM.xlsx-Fig_2D_MSC_targeted_RNF4-Up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
ADGRL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71826
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.943903
OB-06-WW76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253592
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	144.967
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220244
C1orf74	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1143
GSE231891_1_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE57871_11_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:I01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29195
GSE231720,GSE231724_2_v_1_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.149
Stoma	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.528
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0618
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_2_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.151
GSE153867_6_v_8_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NF-19-JL47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.417902
putrescine biosynthetic process from arginine, via ornithine	GO Biological Process Annotations 2025	1.0	null
STC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49283
GSE132694,GSE132717_0_v_2_meis1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Wt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	80.5039
GSE57871_5_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.309
8MGBA	CCLE Cell Line Gene CNV Profiles	1.0	1.69133
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	52.3906
NCI-H2369	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.880221
GSE153907,GSE153908_0_v_1_azathioprine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TMEM51	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02219
Parasitic protozoa infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.366
C2orf74	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60171
GR-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.92323
RBM43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28695
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223028
CRCGN009_HEPG2_24H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7188
ETV3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6666
CTAGE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49277
USP27X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62236
PMC11063202-41420_2024_1940_MOESM2_ESM.xlsx-THP1-EP300_KOvsNontarget-gene_name_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
COLO668	CCLE Cell Line Gene CNV Profiles	1.0	1.85696
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.992343
amygdaloid complex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.926058
postgolgi	GeneRIF Biological Term Annotations	1.0	null
Apical bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.051
inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.940045
CA3 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.13186
CF-50-QK79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209177
GSE71491_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6766640__F3	PFOCR Pathway Figure Associations 2024	1.0	null
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.6214
TE441T	CCLE Cell Line Gene CNV Profiles	-1.0	-3.11697
GSE48812_2_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0243845
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.39145
lateral ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.28701
ornithine decarboxylase activity	GO Molecular Function Annotations 2025	1.0	null
Congestive Heart Failure	DisGeNET Gene-Disease Associations	1.0	null
NCI-H847	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16145
EAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43494
SU-DHL-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.41778
GSE166169_0_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118794_5_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_9_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SLC2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2517
possible	GeneRIF Biological Term Annotations	1.0	null
COV318	CCLE Cell Line Gene CNV Profiles	1.0	1.34539
PMC11426526-ppat.1012555.s011.xlsx-DEG_MDDC_Jurkat_LPS_vs_MDDC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
polyamine transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
HSOS1	DepMap CRISPR Gene Dependency	1.0	2.59621
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.431
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WDR62	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78218
VMRCRCZ	CCLE Cell Line Gene CNV Profiles	-1.0	-1.72278
MDA-MB-175-VII	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.94375
Alanine racemase/group IV decarboxylase, C-terminal	InterPro Predicted Protein Domain Annotations	1.0	null
Charge Syndrome	DisGeNET Gene-Disease Associations	1.0	null
Cerebral hemisphere	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.844339
GSE146687_2_v_0_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.07507
GSE100316_5_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
negative regulation of catabolic process	GO Biological Process Annotations 2025	1.0	null
GSE202434,GSE202438_9_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DENND4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64578
GSE94011_2_v_1_pias3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.694
GSE146982_4_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GID8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28029
GSE193258,GSE193259_9_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC1359	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01358
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.39839
PMC10810548-pone.0289518.s002.xlsx-SOM_w_identifiers-target_gene_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.98534
proliferation	GeneRIF Biological Term Annotations	1.0	null
C1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4462
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Central Neurocytoma	DisGeNET Gene-Disease Associations	1.0	null
Apoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.815
primary auditory cortex (core)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.57352
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.51749
Hyaline inclusion	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.525
SG in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.56625
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.743
JHOS2	CCLE Cell Line Gene CNV Profiles	1.0	1.40503
GSE102757_1_v_0_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
posteroventral (inferior) parietal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.853941
GSE138841_0_v_1_trim6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.8886
positive regulation of catalytic activity	GO Biological Process Annotations 2023	1.0	null
B3GAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12046
IZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.958344
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.304
GATOR2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.923
GTEx Thyroid 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	1.0	6.13456
GSE111247_2_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FE-64-KC49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282125
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.207
Chronic Obstructive Airway Disease	DisGeNET Gene-Disease Associations	1.0	null
SHROOM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14531
TFCP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.9691
Progressive Cgvhd	DisGeNET Gene-Disease Associations	1.0	null
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Contractile vacuole complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.553
SPIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.6159
PMC7203476-Table_2.XLSX-MI_treat_vs_control-Unnamed_0_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Fasudil_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158324
PRODH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3307
MZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25305
GSE114992,GSE114993_0_v_10_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242199_6_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE156923_2_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.901832
primary motor cortex (area M1, area 4)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.62229
Recurrent Tumor	DisGeNET Gene-Phenotype Associations	1.0	null
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.05498
GSE198380_0_v_1_phgdh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cerebral cortex	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE226249_0_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202587_1_v_2_xrn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE179002_2_v_6_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ENSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95037
7513_RPS24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.583011
CRCGN015_HEPG2_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.35181
GSE207914_2_v_7_nudt7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF454	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	138.177
VZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22286
Islet Cell Tumor	DisGeNET Gene-Disease Associations	1.0	null
GIGYF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41535
pyrroline-5-carboxylate reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.438
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLC25A28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3449
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.245
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23774
GSE184892_7_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
SET-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.12739
Osteitis	DisGeNET Gene-Disease Associations	1.0	null
Multiple Myeloma	DisGeNET Gene-Disease Associations	1.0	null
male gamete generation	GO Biological Process Annotations 2015	1.0	null
Childhood Astrocytoma	DisGeNET Gene-Disease Associations	1.0	null
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.8983
NR1I3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7098
outer CP in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.15019
GSE168697_0_v_1_wdr6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE100102_0_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229070,GSE229071_0_v_2_sotorasib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE130715_2_v_3_budesonide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE128730_0_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cellulose microfibril	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.862
UBXN2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02897
GSE221327_4_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
Foxj3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	62.9924
MAT2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10777
CRCGN015_HEPG2_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.73388
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.429
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3214
GSE165334_2_v_0_dabrafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223008_5_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_0_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
AF-80-GK24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262993
4957_MED7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03344
CRCGN016_MCF10A.TP53.M_24H:O20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08
PMC10592471-NIHMS1912771-supplement-2.xlsx-NR2F1-Ind-Upregulated_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
Liver Cirrhosis	DisGeNET Gene-Disease Associations	1.0	null
GSE184902_3_v_1_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE134375_3_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Aerial part	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.676
IEC-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.612
GSE236262_2_v_1_trim28_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brodmann area 35	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.154
ZSCAN29	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6417
positive regulation of polyamine transmembrane transport	GO Biological Process Annotations 2025	1.0	null
IARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73886
GSE98831_1_v_0_brca1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPS9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1491
GSE152937_12_v_7_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SCAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18779
CRCGN014_HEPG2_3H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.81365
cis-Golgi network	GO Cellular Component Annotations 2025	1.0	null
GSE192663_3_v_2_acly_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.27708
lateral ventricle	HPA Tissue Protein Expression Profiles	-1.0	-1.17543
GSE142019,GSE142021_1_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Anther	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.069
KYSE-70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.916105
ZNF263	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.8874
GSE218060_5_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
IZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.871337
GSE168797_1_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
ornithine metabolic process	GO Biological Process Annotations 2015	1.0	null
MAX::MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9524
Non-Small Cell Lung Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE201042_2_v_1_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.4337
Stage I Endometrial Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE120612_4_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.3389
GSE60217_1_v_0_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_2_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
lateral ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.882351
GSE231891_1_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FA-92-JL46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.473505
MJ	DepMap CRISPR Gene Dependency	1.0	3.22509
VZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.11598
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261198
IRF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.41346
GSE192663_3_v_5_acly_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GOS3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44594
KRBOX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67575
trochlear nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.27721
GSE60837_0_v_3_bcl9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.283
GSE161864,GSE161866_1_v_3_ror2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.319586
STING complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.55
Tachyzoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.744
RTEL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54546
GSE240645_3_v_2_u90926_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.36672
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RNASEH2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1513
GOLM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64414
axon	GO Cellular Component Annotations 2023	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2897
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
C11orf98	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10881
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.979682
GSE110268_0_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE89154_1_v_0_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
S100A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42539
GSE183413_0_v_2_ash1l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_12_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ALS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10447
GSE100316_0_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
SG in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.92813
Vascular bundle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.489
GSE236454,GSE236456_0_v_1_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
LIMS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66711
Peripheral nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
EBF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.001
Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
SMTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02774
CAL78	CCLE Cell Line Gene CNV Profiles	1.0	1.5608
Squamous Cell Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
NFATC3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.623
Trigeminal nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.556
GSE158431_2_v_0_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE116930,GSE116935_3_v_6_hes7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1481
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.2337
paracentral lobule, anterior part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.27579
JHU029	DepMap CRISPR Gene Dependency	1.0	2.69641
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEp3_UP_NR2F1_ind_UP-NR2F1_Ind_UP_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
CTNNBL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30021
GSE145915_3_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10746608-427_2023_709_MOESM5_ESM.xlsx-NR3C1_partners-NR3C1_known_protein_partners_according_to_BioGrid_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
defense response to virus	GO Biological Process Annotations 2025	1.0	null
CCNDBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47305
endoplasmic reticulum-golgi intermediate compartment membrane	GO Cellular Component Annotations 2015	1.0	null
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14493
primary auditory cortex (core)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.921055
TRAPPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20013
FOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	75.8303
HCC2998	DepMap CRISPR Gene Dependency	1.0	3.39451
GSE207514,GSE207515_2_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5642521-oncotarget-08-69847-s004.xls-Sheet1-List_of_down_regulated_genes_in_NRF2_KD_A549_cells_FC_1_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE175787_5_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242647_2_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE98705_1_v_0_mdm2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_9_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14729
GSE203158_0_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.6992
KIAA1522	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63376
ZNF766	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5572
EMC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62872
PSMA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29567
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MBD3L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80658
GSE217552_3_v_2_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE101112_6_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_9_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
KYSE-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.854603
A549_TG101209_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145334
andor	GeneRIF Biological Term Annotations	1.0	null
GSE120413,GSE120447_4_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ALG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97493
GSE143743_0_v_2_c9orf72_human	RummaGEO Gene Perturbation Signatures	1.0	null
MYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.8409
agmatine biosynthetic process	GO Biological Process Annotations 2015	1.0	null
ETV5::HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9804
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.941597
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.201
HSF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0597
GSE165636_0_v_4_tofacitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
E2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9763
AFMID	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33076
GSE147240_0_v_7_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE133683_3_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE81796_0_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF816	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	94.6876
GSE142210_4_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPL13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19015
GSE134375_3_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
VPS28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00661
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.14245
GSE190316,GSE190324_1_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.409
UBL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37903
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.90783
HCC1195	CCLE Cell Line Gene CNV Profiles	1.0	1.94786
anterior (rostral) cingulate (medial prefrontal) cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06701
primary auditory cortex (core)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.40943
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20677
DEOC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.13799
neuron part	GO Cellular Component Annotations 2015	1.0	null
NC-27-AD53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200974
MARK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49005
SK-N-DZ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.863087
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Stem nodule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.943
CRCGN009_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.53941
ZNF680	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.0111
Plant tumor tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.337
GSE171269_1_v_4_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_RG108_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227262
GSE196699_2_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.46401
ventrolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.903807
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
SP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	147.391
CRCGN015_HEPG2_48H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.40276
GSE70935_2_v_4_cyfip1_human	RummaGEO Gene Perturbation Signatures	1.0	null
WF-96-ME07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207522
Tongue epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.252
DYRK1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48869
negative regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
MCF7_SRT1720 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149355
reproductive process	GO Biological Process Annotations 2015	1.0	null
GSE128730_4_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Golgi transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.111
KYSE220	DepMap CRISPR Gene Dependency	1.0	2.45738
NCIN87	DepMap CRISPR Gene Dependency	1.0	2.24653
SCRT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5102
RTL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91968
oxoacid metabolic process	GO Biological Process Annotations 2015	1.0	null
CRCGN015_MCF10A_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.6536
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.465
MINDY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.9639
GSE195568_6_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
testis	HPA Tissue Protein Expression Profiles	-1.0	-1.17543
PMC9458733__F4	PFOCR Pathway Figure Associations 2024	1.0	null
LOU-NH91	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.928771
GSE192513,GSE192515_2_v_0_atg16l1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Foxn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.8984
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.932674
GSE82032_3_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Toxic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
KNS81	DepMap CRISPR Gene Dependency	1.0	5.93015
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01924
hsa-miR-30d-5p	MiRTarBase microRNA Targets	1.0	null
preoptic region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.33043
Myelomalacia	DisGeNET Gene-Disease Associations	1.0	null
GSE184902_3_v_1_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223008_5_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Petal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.098
negative regulation of biological process	GO Biological Process Annotations 2015	1.0	null
GSE147662_0_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.94145
GSE175787_5_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE125219,GSE125221_3_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MATK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81229
GSE236502_2_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-Aza_atRA_DE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Squamous Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GC-1 spg cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.99
ISL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.7749
ZNF320	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	240.301
LMX1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.515
Cotyledon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.323
HT1197	DepMap CRISPR Gene Dependency	1.0	3.43845
GSE220629_0_v_1_foxp3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE77108_5_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE128730_0_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KPNRTBM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.97038
GSE134615_1_v_0_lats1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.894722
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.1588
LMNTD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30669
GSE87412,GSE92423_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239688_4_v_0_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
G140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.871175
Molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.666
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.854603
Duodenal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.728
vagina	HPA Tissue Protein Expression Profiles	1.0	1.10356
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PANC0327	DepMap CRISPR Gene Dependency	1.0	3.96402
ZC3H12C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.782
Trypomastigote	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.515
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.67501
TFAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32401
CRCGN012_HEPG2_24H:G19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10885
GSE223008_7_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PANC0213	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39097
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE200352_10_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Callus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.372
Brain edema	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.097
CRCGN008_HEPG2_24H:I18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11195
CRCGN017_MCF10A.WT.HP_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6924
primary amino compound biosynthetic process	GO Biological Process Annotations 2023	1.0	null
GSE168401_1_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
UF-14-LK87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230928
brain	GeneRIF Biological Term Annotations	1.0	null
TCIRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.60988
GSE114284_2_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.8103
cell projection	GO Cellular Component Annotations 2015	1.0	null
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08547
GSE158834_1_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
JHH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.916022
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21861
PLK2_knockdown_87_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.53883
Leydig cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.07
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.8842
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_Jurkat_LPS_vs_DC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
revealed	GeneRIF Biological Term Annotations	1.0	null
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.49614
JHH-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.73409
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.886844
Leaf vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.57
small intestine	HPA Tissue Protein Expression Profiles	1.0	1.10356
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.624429
GSE230744,GSE237803_5_v_3_hira_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152432_1_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
type I interferon-mediated signaling pathway	GO Biological Process Annotations 2025	1.0	null
537_ARPC3_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.538355
Leiomyosarcoma	DisGeNET Gene-Disease Associations	1.0	null
GSE180951_1_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-86-YY62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.422682
HCC1954	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.65724
CORL88	CCLE Cell Line Gene CNV Profiles	1.0	1.98332
organic substance biosynthetic process	GO Biological Process Annotations 2015	1.0	null
fungal-type cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.537
GSE101546_2_v_1_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE254517_2_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126777_3_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE124471,GSE124488_1_v_0_lats1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.564
RNPEPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.587
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14223
Metabolism of polyamines	Reactome Pathways 2024	1.0	null
Hairy root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.38
CBF3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.728
DC-05-LU10_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330057
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.252
GSE224096_1_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE188870,GSE188871_4_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239688_4_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
B875 antenna complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.594
EBV-B cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.116
JB-14-ZM03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244501
anterior (rostral) cingulate (medial prefrontal) cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.863901
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Crohn Disease	DisGeNET Gene-Disease Associations	1.0	null
ABC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.22472
GSE138741,GSE138743_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE246335_4_v_5_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5506
RCC4	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14299
CP in retrosplenial cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.49265
PMC5798892-41421_2017_3_MOESM8_ESM.xlsx-down-regulated-Supplementary_Table_S3_Up-_and_downregulated_genes_in_ATF6-_-_hMSCs_compared_to_ATF6_hMSCs_late_passage_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
SG in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10899
GSE171837_1_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE224294_4_v_2_ngly1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE115363_1_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETV2::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3873
Paraflagellar rod	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.605
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
BC-62-RZ55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.309371
GA-28-SS67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269773
GSE225218_8_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prdm5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.6473
cellular_component	GO Cellular Component Annotations 2015	1.0	null
Pancreatic Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.348082
GSE121809_1_v_0_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hepatocellular Adenoma	DisGeNET Gene-Disease Associations	1.0	null
GSE244710_1_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE70499_3_v_1_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-62-JP26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.411435
lateral hemisphere of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.892381
GSE178255_1_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
frontal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.12704
Invasive Carcinoma Of Breast	DisGeNET Gene-Disease Associations	1.0	null
Plasmacytoid dendritic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.322
Mesothelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.569
GSE186633_2_v_0_chd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.992343
PMC11216188-peerj-12-17616-s013.pdf-8-ZBTB8A_ZBTB8A	Rummagene Transcription Factor Associations 2026	1.0	null
569_ASB8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.583546
NKX2-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1936
GSE77108_5_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
IFT25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16903
Ciliary epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.542
THAP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8321
Metabolism	Reactome Pathways 2014	1.0	null
GSE160246_9_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Newly Diagnosed Childhood Ependymoma	DisGeNET Gene-Disease Associations	1.0	null
KB-77-BA46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21603
DKMG	DepMap CRISPR Gene Dependency	1.0	3.78972
GSE160246_9_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227891_5_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE166920_6_v_4_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
IZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37678
VIM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41604
GSE161864,GSE161866_4_v_3_ror2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Xylem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.451
Theca interna	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.586
Theca folliculi	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.546
POLR3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21838
GSE162892_3_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169334,GSE169336_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lower respiratory tract disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.505
7910_SIGMAR1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.767932
Subpallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.879
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE229914_2_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
globus pallidus, external segment, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.865469
GSE111660_1_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Antler	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.504
PMC12500934-41408_2025_1358_MOESM3_ESM.xlsx-Table_S6-DEGs_p_0_05_between_surviving_or_deceased_DLBCL_patients_that_received_R-CHOP_therapy_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0265
LCMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91339
GSE166920_6_v_8_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
caudal presubiculum (postsubiculum)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.848805
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
GSE70499_5_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211177,GSE211178_8_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
substantia innominata, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.01815
GSE228181_3_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Sperm connecting piece	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.76
PMC7468443-Data_Sheet_2.xlsx-DEG_6h_LPS-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217363_4_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
8040_SLC35A4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.606853
PROCR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48099
GSE155031_5_v_0_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.927398
GSE168798_0_v_1_isg15_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110524_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ZIM3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.8586
T-cell lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.859
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
GSE171572_5_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
Zfp961	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	67.8639
NISCH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53228
PCI38	DepMap CRISPR Gene Dependency	1.0	2.5261
CD40 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.702
QSOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34031
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239527
FOSL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.507
MRPL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10517
Leaf tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.539
Epicotyl	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.455
Brain ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.362
CCDC127	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03088
carboxy-lyase activity	GO Molecular Function Annotations 2023	1.0	null
GSE214596,GSE214598_1_v_4_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
organic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE89057_0_v_1_sox5_human	RummaGEO Gene Perturbation Signatures	1.0	null
AB-17-WP43_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.361686
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.181
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.073
organonitrogen compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
stratum pyramidale of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18068
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.938228
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.196
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238497
ISGF3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.809
Kinetoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.975
azin2	GeneRIF Biological Term Annotations	1.0	null
Root hair	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.941
Esophageal squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.952
K562_Selisistat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015762
Carcinoma Of Bladder	DisGeNET Gene-Disease Associations	1.0	null
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE124410_2_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
biosynthetic process	GO Biological Process Annotations 2015	1.0	null
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	259.094
chr1_33091420_G_A_b38	GTEx eQTL 2025	1.0	2.50587
11307_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.504085
microscopy	GeneRIF Biological Term Annotations	1.0	null
Nucleus dentatus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.703
GSE81796_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mesopallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.125
GSE126127_2_v_1_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE68155_1_v_0_gpr3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SJCRH30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.38421
FOXO1::ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.03
2622_EMG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.544481
PMC11747033-Table1.xlsx-Sup_Table_S1-IFNy_LPS_TREATED_HMEC_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.953154
Infiltrating Cervical Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Uterine fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.884
Delta1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.405
MYL12B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1574
HLF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5386
SIG-M5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.08113
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06079
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24976
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TLR7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18674
GSE200352_1_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
serine-tRNA ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.956
ANO9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43476
AR-35413990-HUMAN-ARPOSCRPROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN017_MCF10A.TP53.M_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29444
inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.873031
MFAP3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82568
GSE166944_3_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
rab9	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.675
H2AC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11812
GSE97352_3_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PRDM9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	266.046
hippocampus (hippocampal formation)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.892625
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250628
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SETBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48712
GSE185944_2_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Plastid thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.85
H4C11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10445
Cirrhosis	DisGeNET Gene-Disease Associations	1.0	null
CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08893
GSE211425_1_v_0_mettl3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE123825_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE232223_1_v_0_letmd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_0_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
neuron projection	GO Cellular Component Annotations 2025	1.0	null
CRCGN011_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04955
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.85963
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8033
FF-54-JC89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221214
GSE196699_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF460	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33466
PARP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03587
Pursuit maintenance gain	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.504576
NCIH1092	CCLE Cell Line Gene CNV Profiles	1.0	1.35903
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4651
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE211128_7_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE117643_1_v_0_irx5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DDX56	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33027
Arbuscule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.84
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
Dlx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.8504
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
SIX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7283
EPS8L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52464
Intercalary meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.285
cell part	GO Cellular Component Annotations 2015	1.0	null
GSE211177,GSE211178_9_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RNF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63612
GSE147943_7_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205163,GSE205164_2_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0394
agmatine biosynthetic process	GO Biological Process Annotations 2025	1.0	null
GSE158834_10_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GSE226249_0_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NAB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.961
Photosynthetic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.586
CDC34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39605
GSE81803,GSE81912_0_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE159893_2_v_1_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
PPP1R18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66802
PTPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31049
GSE167956_1_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
SEPTIN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22873
paraventricular nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11971
GSE174701_5_v_8_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Childhood Leiomyosarcoma	DisGeNET Gene-Disease Associations	1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.17
ARNT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7224
CRCGN015_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0958
Posterior periventricular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.739
PDGFRB_knockdown_114_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.50751
GSE213588_10_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:F08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1962
GSE221577_1_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160817_4_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GATOR1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.619
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.1171
Gastrointestinal Carcinoid Tumor	DisGeNET Gene-Disease Associations	1.0	null
GSE135030_3_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211836
BATF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0338
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.992343
Malignant Transformation	DisGeNET Gene-Phenotype Associations	1.0	null
PSMF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27159
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24976
GSE169697,GSE169725_0_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ANKFY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69649
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TBR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8918
SERF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37184
GSE169590_6_v_5_rptor_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125153_1_v_3_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.54931
GSE99187_1_v_0_gemcitabine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE248045,GSE248046_6_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
neurons	GeneRIF Biological Term Annotations	1.0	null
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
negative regulation of protein metabolic process	GO Biological Process Annotations 2023	1.0	null
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CSTF2T	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05404
SNU5	CCLE Cell Line Gene CNV Profiles	-1.0	-2.03063
MTG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45037
ESS1	DepMap CRISPR Gene Dependency	1.0	4.27581
GSE152432_5_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154767_2_v_3_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PSII associated light-harvesting complex II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.804
GSE125782_3_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95685_2_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Aleurone layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.904
positive regulation of polyamine transmembrane transport	GO Biological Process Annotations 2023	1.0	null
Cholangiocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.635
GSE104508_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Syndromic X-linked intellectual disability Snyder type	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.56
MZ in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01498
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.396622
GSE216273,GSE216292_0_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285573
ZFPM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17873
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223825
GSE154350_1_v_0_ascl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DNAAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65061
nitrogen compound transport	GO Biological Process Annotations 2015	1.0	null
FOSB::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4349
inorganic cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Middle Cerebral Artery Occlusion	DisGeNET Gene-Disease Associations	1.0	null
GSE198165,GSE198166_7_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ITGB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45327
locus ceruleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.970307
496100584_HIP_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.13062
transport vesicle	GO Cellular Component Annotations 2015	1.0	null
HCC1419	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.839402
GSE152050,GSE152052_1_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE95077_1_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
striatum_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.86564
hsa-miR-4763-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.656
Endodermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.646
GSE233049_1_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE232558_0_v_2_fbxl12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H2081	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24976
GSE110178_4_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6932815-ppat.1007634.s014.xlsx-ST4_DGE_ELF1-R8AvIFN6-mock_lfc2-ensembl_gene_id_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.28538
Prostate Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_9_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ALKBH5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49079
granular vesicle	GO Cellular Component Annotations 2023	1.0	null
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11439
posteroventral (inferior) parietal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03561
Nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE230329_0_v_3_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ETV5::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.4517
GSE44157,GSE44163_3_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2593
GSE152432_3_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.5962
Abscission zone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.883
Metastatic Renal Cell Cancer	DisGeNET Gene-Disease Associations	1.0	null
SMSCTR	DepMap CRISPR Gene Dependency	1.0	2.94499
Adult Pilocytic Astrocytoma	DisGeNET Gene-Disease Associations	1.0	null
GSE111102,GSE111105_8_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FGF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17104
GSE94011_0_v_3_pias3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mixed Salivary Gland Tumor	DisGeNET Gene-Disease Associations	1.0	null
DES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26508
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RAP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78508
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.918208
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.27682
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20772
GSE216326_2_v_0_sulodexide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
transgolgi	GeneRIF Biological Term Annotations	1.0	null
Inflammatory bowel disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.147
GSE146546,GSE146807_0_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11461876-42003_2024_6975_MOESM3_ESM.xlsx-Supplementary_Data_1-Supplementary_Data_1_Differentially_Expressed_Genes_HSE_THP1_Vs_THP1_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
EXOSC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.02704
KMRC3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.5561
TNIK_knockdown_297_GSE17623	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.03276
GSE111247_0_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOS::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0865
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.859132
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6381
GSE165579_0_v_1_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
inferior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.21818
CRCGN015_HEPG2_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.94494
GSE114992,GSE114993_7_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36849
GSE80446_2_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE157296,GSE157298_4_v_2_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.89
hsa-miR-4722-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GSE211177,GSE211178_4_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Agmatine	MW Enzyme Metabolite Associations	1.0	null
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.38221
B3GNT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61033
FUS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96222
Cerebral Abscess	DisGeNET Gene-Disease Associations	1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.163
Squamous Cell Carcinoma Of The Head And Neck	DisGeNET Gene-Disease Associations	1.0	null
SET-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04434
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1512
PBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.4195
A549_Fedratinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137068
GTEx Muscle 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	5.81496
PMC9038526-mmc1.xlsx-postCOVID_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.7116
GSE124410_2_v_5_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.73225
GSE134412_0_v_1_siah2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE172295_1_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE240896,GSE240899_5_v_4_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80735
Pollen wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.627
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.663951
protein kinase complex	GO Cellular Component Annotations 2025	1.0	null
Tfcp2l1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.8575
GP2D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.11108
GSE147283_1_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE57871_6_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SG in posterior frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.54905
Urinary bladder squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.501
Golgi apparatus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.842847
GSE198794_2_v_1_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
MOB3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22942
GSE164874_5_v_7_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
striatum_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.908112
GSE186005_1_v_2_klf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MUTYH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57891
LRRN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13259
GSE42805,GSE42811_1_v_0_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Mast cell granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.329
MBLAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02101
NUGC-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.893833
CRCGN015_MCF10A_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.8207
SECISBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04979
GSE148066,GSE157787_5_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.6063
GSE131798,GSE131804_2_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.66043
Aa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.745
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.6264
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.069
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Atf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.702
TYKNU	CCLE Cell Line Gene CNV Profiles	1.0	1.55324
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.8963
GSE196671_6_v_8_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223008_11_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.698995
GSE216757_4_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13734
NR1D1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9093
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.2437
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.053
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.279
C4orf46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.47123
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.80615
Symplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.701
GSE210662_2_v_0_znf165_human	RummaGEO Gene Perturbation Signatures	1.0	null
differentiated	GeneRIF Biological Term Annotations	1.0	null
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cellular amine metabolic process	GO Biological Process Annotations 2015	1.0	null
MAP4K2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03828
anterior (rostral) cingulate (medial prefrontal) cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.4321
Pain	DisGeNET Gene-Phenotype Associations	1.0	null
granular vesicle	GO Cellular Component Annotations 2015	1.0	null
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.20523
GSE128730_0_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237482
AA-62-JP26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.295826
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.57092
Reservosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.504
Contracture	DisGeNET Gene-Disease Associations	1.0	null
GSE223008_5_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.992343
GSE68155_3_v_2_gpr3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10117100-msphere.00056-23-s0008.xlsx-2B-Supplementary_Table_S2B_mRNAseq_analysis_genes_significantely_downregulated_upon_E2F4-5_knockdown_in_38HK_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
PA-15-CP52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.36638
GSE142210_3_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
orbital frontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.872944
GSE111385_0_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
metabolic process	GO Biological Process Annotations 2015	1.0	null
CHP212	CCLE Cell Line Gene CNV Profiles	-1.0	-2.44205
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.81671
GSE182680,GSE182683_10_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BC-09-XQ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204325
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.351218
GSE113329,GSE113335_3_v_4_taf6l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DHX9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89795
ZNF417	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4124
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14116
PFN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69717
SYNGR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57479
Root cap	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.749
negative regulation of protein catabolic process	GO Biological Process Annotations 2015	1.0	null
FAM193A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26933
GP5D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.23145
GSE146840,GSE146842_3_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SNCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25335
GSE142210_11_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
putrescine transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GSE203308_14_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lateral root primordium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.851
Entorhinal area	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.018
MCF7_ABT-737_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134802
Echinococcosis	DisGeNET Gene-Disease Associations	1.0	null
K562_CUDC-907_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182509
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.0048
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.944649
FAM110D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83698
GSE162892_3_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of transmembrane transport	GO Biological Process Annotations 2015	1.0	null
ZPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46413
horsetail-astral microtubule array	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.675
A549_Anacardic Acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138451
GSE184884_2_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TNKS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50383
GSE210476_11_v_10_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0256
GSE196117_1_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.933207
CRCGN017_MCF10A.WT.HP_24H:P17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8909
Perikaryon	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN015_MCF10A_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.7732
GSE151160_0_v_1_cd36_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GGT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20646
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204346
GSE134214_0_v_1_ell2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110440_2_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH510	CCLE Cell Line Gene CNV Profiles	1.0	1.78583
GSE233679_6_v_2_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.907288
cingulate gyrus, retrosplenial part, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01198
molecular function regulator	GO Molecular Function Annotations 2015	1.0	null
COL7A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50099
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
TWIST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34867
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
esophagus	HPA Tissue Protein Expression Profiles	1.0	1.10356
GSE137144_2_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Glesatinib(MGCD265)_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172924
Bone marrow cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE128634,GSE128636_2_v_0_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223008_11_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CA-42-YI34_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275677
primary motor cortex (area M1, area 4)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16729
CAL-85-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11548
MFSD13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89648
ARAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68166
GSE142019,GSE142021_10_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
golgi apparatus part	GO Cellular Component Annotations 2015	1.0	null
GSE250534_4_v_1_cabergoline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_10_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TRPS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9056
AC-50-FR41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.383509
UBXN2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54147
PMC9232687-13238_2021_887_MOESM3_ESM.xlsx-37_KD_sgCDC20_vs_sgNTC-Differentially_expressed_genes_DEGs_upon_CDC20_knockdown_under_37_culture_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7966
PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_6_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
COV434	DepMap CRISPR Gene Dependency	1.0	5.67299
DA-58-LZ09_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287845
PMC5687749-pone.0188272.s005.xlsx-Supplementary_Table_3-Supplementary_Table_3_Differentially_Expressed_Genes_in_Common_between_AFX_compared_to_both_Keratinocytes_and_Fibroblasts_FOXO4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11167905-10194_2024_1805_MOESM1_ESM.xlsx-S6-Table_S6_MR_results_of_brain_eQTLs_and_migraine_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Germinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE70499_0_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.574
ETFDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18966
FKRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59512
GSE114685_1_v_0_grin2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
spleen	HPA Tissue Protein Expression Profiles	-1.0	-1.17543
GSE241701_1_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4865
GRANTA519	CCLE Cell Line Gene CNV Profiles	-1.0	-1.73633
GSE205070_1_v_6_mertk_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
different	GeneRIF Biological Term Annotations	1.0	null
GSE201217_4_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXO1::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.8631
GSE196110_1_v_2_ndrg3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.35209
GSE89018_1_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ETV5::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.9961
FBXL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.04517
GSE158834_0_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
RAB1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37325
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286337
GSE175787_8_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF675	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	85.4831
Solid Neoplasm	DisGeNET Gene-Phenotype Associations	1.0	null
TEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6473
KPNYN	CCLE Cell Line Gene CNV Profiles	-1.0	-1.87697
Liver cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
OXLD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17251
TRAPPC2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22789
CRCGN015_HEPG2_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5991
GSE149621_0_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE150669_2_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
GSE226249_2_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04337
GSE146687_2_v_1_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358173
FUT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71531
GSE179880_7_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_5_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114883_0_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
cellular nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
SNU1196	DepMap CRISPR Gene Dependency	1.0	2.78344
GSE198434_1_v_0_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.273
Malignant Glioma	DisGeNET Gene-Disease Associations	1.0	null
FDXACB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14479
GSE211151_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE199874_3_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Parahippocampal region	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.221
Endometrial Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE201110_0_v_1_sirt4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
negative regulation of catabolic process	GO Biological Process Annotations 2023	1.0	null
GSE188870,GSE188871_4_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PC-62-AQ92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263843
GSE148066,GSE157787_5_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE221742,GSE221743_1_v_0_sipa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
KLF10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	168.949
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07107
GSE161064,GSE161065_0_v_1_kdm5b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
CCDC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95118
GSE145639_1_v_2_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8709578-elife-69843-supp4.xlsx-HSF1_ChIP-seq_peaks-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Adventitious root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.105
IE-38-FB31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234134
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20677
GSE87404,GSE87812_2_v_3_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UPF3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06883
ZNF490	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.35451
inferior olivary complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.856517
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE232472_1_v_2_apoe_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8020666-pnas.2015855118.sd09.xlsx-LPS_24_human_DRSG_lowerRes-Ensemble_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Carcinoma, Neuroendocrine	DisGeNET Gene-Disease Associations	1.0	null
IZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10715
SOX12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8098
Golgi apparatus subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
TMEM200B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36752
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.115
GSE119978,GSE180930_2_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE100464,GSE100465_0_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE173997_1_v_0_clic4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.985
GSE133213_9_v_15_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE143830_0_v_1_trex1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE221327_5_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE98964_1_v_4_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
striatum_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.35439
positive regulation of transport	GO Biological Process Annotations 2015	1.0	null
Abscess	DisGeNET Gene-Phenotype Associations	1.0	null
BYSL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08968
Proteasome storage granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.069
PMC8020666-pnas.2015855118.sd09.xlsx-LPS_4_human_DRSG_lowerRes-Ensemble_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242199_2_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE189859,GSE189861_0_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.36165
CLSPN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75597
IZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0245
GSE121319_1_v_2_gprc5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
substrate-specific transporter activity	GO Molecular Function Annotations 2015	1.0	null
nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE127790_5_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JB-14-TF61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.395012
VZ in caudal cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.44158
GSE193258,GSE193259_9_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Arginine and proline metabolism	KEGG Pathways 2026	1.0	null
ABCF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32632
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.476756
Thyroid Nodule	DisGeNET Gene-Disease Associations	1.0	null
GSE189683_1_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111385_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149903_0_v_1_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-23-FM46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221131
striatum_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.900378
HS 675.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00706
GARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83865
amygdaloid complex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.50938
trans-Golgi network membrane organization	GO Biological Process Annotations 2023	1.0	null
DOV13	CCLE Cell Line Gene CNV Profiles	1.0	2.14613
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.834176
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.5925
NXT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36633
striatum_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08157
GSE146840,GSE146842_1_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.221
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.55
IMR32	CCLE Cell Line Gene CNV Profiles	-1.0	-2.3261
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.0475
Claustrum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.874
CRCGN015_MCF10A_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11255
HC-01-FD24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211921
CNOT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.585
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.6811
molecular_function	GO Molecular Function Annotations 2015	1.0	null
ZNF738	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74262
A-498	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.60094
cellular biosynthetic process	GO Biological Process Annotations 2015	1.0	null
cochlear nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.891577
organic substance transport	GO Biological Process Annotations 2015	1.0	null
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
C1orf210	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45569
ACP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85563
GSE111247_11_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
testis	GeneRIF Biological Term Annotations	1.0	null
PMC8569982-41065_2021_205_MOESM1_ESM.xlsx-mono_THP1_a2b_tpm1-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149359_2_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.3474
negative regulation of protein metabolic process	GO Biological Process Annotations 2015	1.0	null
Irf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	42.4134
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252236
axon	GO Cellular Component Annotations 2015	1.0	null
LRR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2517
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.6811
GSE112962,GSE112963_2_v_1_ddx5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118077_4_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Pracinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018085
CA2 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03478
Intercalated cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.718
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224122
GSE67266_7_v_3_etoposide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZYX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08553
Cardiac Arrest	DisGeNET Gene-Disease Associations	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Supplementary_Table_2E_Contrast_ATF4-def_Tg_8h_vs_HCT116_Tg_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
Adult Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
negative regulation of catabolic process	GO Biological Process Annotations 2015	1.0	null
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8281
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8851354-Table_6.xlsx-STAT3-bound_genes_GM12878-Supplementary_Table_6_STAT3-bound_unique_genes_in_GM12878_cells_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
SW 48	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE94849_1_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mesothelioma	DisGeNET Gene-Disease Associations	1.0	null
IC-80-CT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.346924
PLAG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	152.833
MAP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35604
GATA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18698
IKZF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64067
CNTNAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1231
GSE223893_4_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.622
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.0833
GSE175787_13_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RNF103	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09066
GSE70499_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Phagophore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.436
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
positive regulation of catalytic activity	GO Biological Process Annotations 2025	1.0	null
magnocellular division of VA	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.878272
ZNF184	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.8482
ADIPOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78922
GSE68156_3_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DA-27-BW20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249163
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.231
Pediatric Intraocular Retinoblastoma	DisGeNET Gene-Disease Associations	1.0	null
KLF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	170.988
GSE92434_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cellular biogenic amine metabolic process	GO Biological Process Annotations 2015	1.0	null
ZNF281	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11293
CDC25A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3536
GSE100102_0_v_3_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inorganic anion transport	GO Biological Process Annotations 2015	1.0	null
Agmatine biosynthesis	Reactome Pathways 2014	1.0	null
Panicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.895
GSE57871_5_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
polyamine transport	GO Biological Process Annotations 2015	1.0	null
Piriform area	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.769
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.33488
GSE247764_5_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11336098-41598_2024_70235_MOESM1_ESM.pdf-306-ZSCAN12_ZSCAN12	Rummagene Transcription Factor Associations 2026	1.0	null
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07455
GSE158834_2_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Usual Interstitial Pneumonia	DisGeNET Gene-Disease Associations	1.0	null
CRCGN011_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.41425
H2AC16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33015
GSE225982_1_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
Benign Prostatic Hyperplasia	DisGeNET Gene-Disease Associations	1.0	null
PPIF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.03001
hippocampus (hippocampal formation)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05331
GSE221020,GSE221023_2_v_1_pten_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NR2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1718
Secondary cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.738
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
membrane-bounded vesicle	GO Cellular Component Annotations 2015	1.0	null
Secondary progressive multiple sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.536
HCC70	CCLE Cell Line Gene CNV Profiles	1.0	1.49339
Somatic embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.755
ZBTB7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13005
positive regulation of molecular function	GO Biological Process Annotations 2015	1.0	null
TNFRSF12A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19199
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETS1_ETS1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202434,GSE202438_12_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PAXBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7338
ERF::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.4819
nitric-oxide synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.295
ZNF700	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09465
nucleus	GO Cellular Component Annotations 2023	1.0	null
motor nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09724
GB-73-QS80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.299657
EWSR1-FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	211.533
STK17A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86404
ZFP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63766
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.4876
IL4R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79493
EDARADD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93027
GSE240258_0_v_1_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BHLHE40	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5875
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.938315
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Kidney Cortex Necrosis	DisGeNET Gene-Disease Associations	1.0	null
4651_LRP8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.12557
CAMLG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66223
Trunk kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.584
JUN::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.153
secretory	GeneRIF Biological Term Annotations	1.0	null
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8088
GSE148066,GSE157787_9_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SK-LMS-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.653
S0-EE-Y97N_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241225
PMC11711664-41598_2025_85366_MOESM6_ESM.xlsx-AA-METABOLIC_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
PEG10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40482
CRCGN015_HEPG2_48H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.48112
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
AD-51-FB60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23965
GSE184892_0_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HUH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02747
PMC8185471-mmc6.xlsx-up-_and_downregulated_genes-Day_6_SOX15-_-_upregulated_and_downregulated_genes_nearby_shared_FO_and_FC_regions_respectively_Related_to_Figure_6_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
GTF3C2-35216376-H9-HUMAN-BONEMARROW-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
Aplasia Cutis Congenita	DisGeNET Gene-Disease Associations	1.0	null
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.4768
ZBED1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6533
CTSZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52277
regulation of polyamine transmembrane transport	GO Biological Process Annotations 2023	1.0	null
IC-05-AW29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30693
DOK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96344
GSE145915_5_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CIR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53098
SP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.832752
GSE207978_1_v_0_rai1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157296,GSE157298_4_v_3_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184892_6_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
ATP6V0E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05763
ITGA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62082
GSE128730_4_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
E2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	114.821
Childhood Pilocytic Astrocytoma	DisGeNET Gene-Disease Associations	1.0	null
oculomotor nuclear complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.16139
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.82912
hsa-miR-151a-3p	MiRTarBase microRNA Targets	1.0	null
hsa-miR-4684-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.348832
Demyelinating disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.892
Diffuse Astrocytoma	DisGeNET Gene-Disease Associations	1.0	null
membrane organization	GO Biological Process Annotations 2025	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
MCF7_Sorafenib Tosylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121457
Plasma membrane bounded cell projection	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE199606_2_v_7_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Conventional (Clear Cell) Renal Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
PMC11067031-pnas.2317690121.sd05.xlsx-Sheet1-Differentially_expressed_genes_between_PML_RARA_GFP_vs_Empty_vector_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
4-aminobutyrate transaminase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.955
GSE147893,GSE147897_2_v_1_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_ABT-737_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.029991
GSE190235_0_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DCUN1D3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.54025
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
GSE190316,GSE190324_10_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228125_2_v_1_ptafr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02977
NH6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.69827
GSE139016_3_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_10_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.371
Urea cycle disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
GSE86507,GSE86509_4_v_5_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213153_1_v_0_ulixertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE118816_2_v_1_myo1c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180185_4_v_10_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223008_11_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Transforming growth factor beta activated kinase 1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.935
APEH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3012
GSE226770_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAF::NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.9394
GSE114992,GSE114993_0_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199899_4_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DBNDD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79571
GSE137818_3_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.6016
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.47718
USH1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45185
ERF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2668
NRL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11476
hormones	GeneRIF Biological Term Annotations	1.0	null
DHRS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63573
IMR-32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.67846
Microspore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.568
GSE118766_2_v_3_ifng_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Testicular Diseases	CTD Gene-Disease Associations	1.0	1.30056
GSE169356_0_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Guard cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.213
COP9 signalosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.244
GSE65617_0_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	90.3363
CRCGN009_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.86752
Developmental Delay (Disorder)	DisGeNET Gene-Phenotype Associations	1.0	null
PMC12659123-12864_2025_12285_MOESM12_ESM.xlsx-Table_S12-Table_S12_Differentially_expressed_genes_after_SPI1_knockdown_SPI1	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.47371
GSE86507,GSE86509_4_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0058
Barrett Esophagus	DisGeNET Gene-Disease Associations	1.0	null
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.174
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.505
Chloroplast thylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.964
oral mucosa	HPA Tissue Protein Expression Profiles	1.0	1.10356
Metabolism	Reactome Pathways 2024	1.0	null
3-isopropylmalate dehydratase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.539
Salivary gland cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.726
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.85999
PRMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95436
HT-144	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.854603
VZ in rostral cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.66432
LB-65-SM65_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248801
perikaryon	GO Cellular Component Annotations 2015	1.0	null
GSE182680,GSE182683_7_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE196699_2_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
supraoptic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.6276
BICR22	DepMap CRISPR Gene Dependency	1.0	4.41704
trans-Golgi network	GO Cellular Component Annotations 2023	1.0	null
XBP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5391
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE136627_2_v_1_hdac4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119978,GSE180930_3_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147662_2_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Zfx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	98.7474
G-402	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.25216
GSE158431_5_v_7_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.836423
GSE146156_2_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SUPHD1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.99459
serine/threonine protein kinase complex	GO Cellular Component Annotations 2025	1.0	null
Lung Melanoma	DisGeNET Gene-Disease Associations	1.0	null
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Msx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.7206
Parasitic infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.395
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE223008_6_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Leaf epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.593
GSE164463_4_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IC-05-AW29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.434856
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE247862,GSE247863_0_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_4_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Tie2 kinase inhibitor_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0119283
SLC7A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33131
cis-Golgi network	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.808
GSE202434,GSE202438_13_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.352036
NAA20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35186
GSE193258,GSE193259_2_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
polyamine metabolic process	GO Biological Process Annotations 2015	1.0	null
Rectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
neuron projection	GO Cellular Component Annotations 2023	1.0	null
GSE112761,GSE112767_2_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
GSE114232_8_v_6_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
bed  nucleus of stria terminalis, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.84311
Cognitive decline (age-related)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.6
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3N_Peaks_YAP1FAM118B_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.25948
GSE148066,GSE157787_0_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_8_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PGF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54374
posteroventral (inferior) parietal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.887396
SMAD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6322
HIF-2alpha_DEPLETION_GDS2760_643_human_Hypoxic MCF-7 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Substantia nigra	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Metastatic Renal Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
HOXD12::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0567
HES7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.225
CREB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8869
plant-type cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.11
GSE198165,GSE198166_7_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WNT5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05893
PRKD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28303
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
GADD45G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57051
Disease Models, Animal	CTD Gene-Disease Associations	1.0	1.17596
GSE198982,GSE198986_1_v_2_daunorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DB-21-FY25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.365034
OVCA 420	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.979682
ammonium transport	GO Biological Process Annotations 2015	1.0	null
IGR39	DepMap CRISPR Gene Dependency	1.0	3.02084
Adenocarcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.41059
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE181959_3_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Macular Retinal Edema	DisGeNET Gene-Disease Associations	1.0	null
GSE233679_6_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE249098_3_v_2_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JHH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05403
A549_Ellagic acid_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116801
HS-SULTAN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.959842
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.988841
IZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.961492
RDES	DepMap CRISPR Gene Dependency	1.0	3.09337
PMC12358249-supplementary_table_s5_ioaf064.xlsx-DMRT1_-_vs_WT__4_months-Unnamed_1_DMRT1	Rummagene Transcription Factor Associations 2026	1.0	null
positive regulation of transmembrane transport	GO Biological Process Annotations 2023	1.0	null
Supraoptic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.77
Ependymoma	DisGeNET Gene-Disease Associations	1.0	null
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08148
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-human_mouse_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE252958_1_v_0_znf469_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Adult Meningioma	DisGeNET Gene-Disease Associations	1.0	null
GSE116810_2_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.897305
GSE163297_0_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.71248
GSE165071,GSE165072_1_v_0_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RBM25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62707
LB771HNC	DepMap CRISPR Gene Dependency	1.0	2.06706
COMMD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03588
BC-13-OQ01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.325565
transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GSE160077,GSE160084_3_v_0_bin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HTC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.724
PRMT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66408
GSE160817_3_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211989_3_v_2_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.622349
FD-29-MM50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240229
amine metabolic process	GO Biological Process Annotations 2015	1.0	null
SU-DHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.62736
GSE146840,GSE146842_0_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.869
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.2173
PRRC2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60985
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.8671
BATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.4688
Colonocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.986
binding	GO Molecular Function Annotations 2015	1.0	null
CSNK1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46321
Adventitious root primordium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.741
RYK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88175
degraded	GeneRIF Biological Term Annotations	1.0	null
TMD8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.12633
GSE213228_2_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE185139_1_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ARPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1226
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11184
NFATC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5844
ARL4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62396
CREB3L4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3497
GSE102505_6_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Spongiome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.261
superior frontal gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.888672
Adult Leiomyosarcoma	DisGeNET Gene-Disease Associations	1.0	null
AB-00-IL62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268502
single-organism transport	GO Biological Process Annotations 2015	1.0	null
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE166169_2_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE191174_0_v_1_ccdc92_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.522816
EKVX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14223
K562_Sodium Phenylbutyrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160356
PMC9170821-JCMM-26-3183-s001.xlsx-Mic_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.58825
GSE228263_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.8536
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.39543
CRCGN011_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13075
Forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.401464
implies	GeneRIF Biological Term Annotations	1.0	null
SEC61B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53421
GSE111247_2_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE102505_1_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Dok	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.691
GSE223008_6_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.854603
GSE153189_1_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.5488
release	GeneRIF Biological Term Annotations	1.0	null
GSE134375_4_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE58724_1_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.5484
spermatogenesis	GO Biological Process Annotations 2015	1.0	null
U343	DepMap CRISPR Gene Dependency	1.0	2.48942
arginine decarboxylase activity	GO Molecular Function Annotations 2025	1.0	null
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.40677
Lateral Meningocele Syndrome	DisGeNET Gene-Disease Associations	1.0	null
PRDM15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43752
Small Cell Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
Vascular tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.356
Noninfiltrating Intraductal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE149943_2_v_3_cd8a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16895
CRCGN009_HEPG2_24H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8746
GSE149903_5_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KLE	CCLE Cell Line Gene CNV Profiles	1.0	1.46819
GSE242199_9_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TYK-NU.CP-R	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05973
Heart Failure	DisGeNET Gene-Disease Associations	1.0	null
Astrocytoma	DisGeNET Gene-Disease Associations	1.0	null
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AB-84-PK04_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.352906
Glioma	DisGeNET Gene-Disease Associations	1.0	null
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.188
plant-type vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.859
K562_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177486
organonitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE88819_11_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AA-46-GL76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228027
Muscle - Skeletal	GTEx Tissue Gene Expression Profiles 2023	1.0	2.46532
localization	GeneRIF Biological Term Annotations	1.0	null
GSE182680,GSE182683_7_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
VMRCLCP	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41477
GSE197257_0_v_1_gpd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SF3B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41556
PMC11063202-41420_2024_1940_MOESM2_ESM.xlsx-THP1-EP300_KOvsNontarget-gene_id_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.02261
GSE118794_0_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EOGT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44711
Leaf disc	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.168
GSE221577_3_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.968201
CRCGN017_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.74248
PMC5105166-ncomms13331-s11.xlsx-Sheet1-Supplementary_Data_10_Overlap_of_upregulated_genes_in_MEF2D-rearranged_cases_with_public_ChIPseq_RNAseq_data_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
Pick body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.831
HOP-92	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.829369
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04337
GSE167546_1_v_2_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCRIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34794
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.602
USE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07458
GSE70499_5_v_6_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-50-FR41_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.278404
GSE153189_1_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE189653,GSE203344_4_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Photosystem I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.806
Glial cytoplasmic inclusion	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.554
organic cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GSE226544_1_v_0_hnrnpa2b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
DDX27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.49676
GSE159937_1_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_9_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:J06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09882
Hemolytic-Uremic Syndrome	DisGeNET Gene-Disease Associations	1.0	null
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3907
PAX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08207
negative regulation of protein catabolic process	GO Biological Process Annotations 2023	1.0	null
GSE193588_1_v_2_pax3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_2_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPRM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28376
GSE153137,GSE153140_2_v_0_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ODF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93931
GSE176008_8_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pparg::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.3804
Carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN016_MCF10A.TP53.M_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1344
GSE146982_7_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE250534_2_v_3_cabergoline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_7_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU1196	CCLE Cell Line Gene CNV Profiles	1.0	1.84428
Ornithine decarboxylase	InterPro Predicted Protein Domain Annotations	1.0	null
TBX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3227
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Phloem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.849
BATF::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1741
APOBEC3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.2701
KB-72-ID36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.357242
NR2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.1453
subcallosal cingulate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08377
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.35064
GSE218356_1_v_0_cited1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215174
NDUFS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38609
anterior hypothalamic area, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15424
KKU100	DepMap CRISPR Gene Dependency	1.0	6.63144
Phagophore assembly site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.803
CRCGN014_HEPG2_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29351
3978_HSPA5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.43548
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.452
GSE203158_0_v_13_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE247862,GSE247863_0_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE103068_0_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE104508_0_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
urinary bladder	HPA Tissue Protein Expression Profiles	1.0	1.10356
GSE130383_1_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYCN2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.134
KMS-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.96749
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04236
outer CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.973564
ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.504
GSE130217_0_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
caudal prosubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.831647
GSE196699_2_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_0_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
regulation of protein catabolic process	GO Biological Process Annotations 2025	1.0	null
ZNF133	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47282
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04236
protein binding	GO Molecular Function Annotations 2015	1.0	null
purposes	GeneRIF Biological Term Annotations	1.0	null
TUBA1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96659
CRCGN015_MCF10A.WT.HP_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36095
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
lateral group of nuclei, right, dorsal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.21028
Amnesia	DisGeNET Gene-Disease Associations	1.0	null
GSE142210_4_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
immunoelectron	GeneRIF Biological Term Annotations	1.0	null
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231955
GSE125153_1_v_0_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Renal epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.811
C2BBE1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.72674
GR-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.9664
Invasive Cancer	DisGeNET Gene-Phenotype Associations	1.0	null
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.294389
GSE246911,GSE246913_4_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEP3_UP_AA_UP-AA_UP_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE189653,GSE203344_2_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PROX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1005
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251173
GSE77108_8_v_7_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148066,GSE157787_8_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186471_1_v_2_carnosol_human	RummaGEO Drug Perturbation Signatures	1.0	null
trochlear nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.3731
GSE230656_0_v_1_gsdmd_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.087
SPDEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9186
PMC6766640__F3	PFOCR Pathway Figure Associations 2023	1.0	null
FOS::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9677
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.909
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JJ012	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00048
KO52	CCLE Cell Line Gene CNV Profiles	1.0	1.46008
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04337
SUMO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43279
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
GSE101239_4_v_2_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9396
GTPBP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57506
GSE175787_4_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
9175_TOP2A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.526391
primary amino compound biosynthetic process	GO Biological Process Annotations 2025	1.0	null
GSE118617,GSE118619_2_v_3_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_9_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CAPZA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.75392
Intine	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.138
Cell projection	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.922517
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE199606_2_v_7_csf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223008_5_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
C18orf32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.35748
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE164757,GSE164759_1_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40646
GSE202434,GSE202438_7_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242096,GSE242098_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2398
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02726
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.451
ACTR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64617
GSE184902_4_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.306
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112761,GSE112767_1_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CHLA266	DepMap CRISPR Gene Dependency	1.0	2.40653
GSE123861_1_v_0_sin3a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE162384_1_v_0_tfam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE175787_4_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE225684_0_v_2_tfap4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Uterine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.177
BE-82-TS38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.296568
ZNF471	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25061
HEL9217	CCLE Cell Line Gene CNV Profiles	1.0	1.49867
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.26356
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.332728
GSE187006_0_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE183251_1_v_3_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.4274
GSE119978,GSE180930_6_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CCRF-SB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.830213
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256721
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3554
GSE235550_2_v_0_hspa9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Jun	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.5735
LRRC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47499
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230552
Tripartite ATP-independent periplasmic transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.615
GCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84082
restricted	GeneRIF Biological Term Annotations	1.0	null
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.272
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.1
MAPACHS77	DepMap CRISPR Gene Dependency	1.0	2.03264
GSE158834_10_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.38549
Aids (Disease)	DisGeNET Gene-Disease Associations	1.0	null
CLUH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35704
SCC-9	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.78644
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.894737
GTEx Thyroid 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	6.32936
RK-13 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.822
GSE185519_3_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CACO-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.157
GINS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22724
dorsolateral prefrontal cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.938755
NCIH28	DepMap CRISPR Gene Dependency	1.0	5.08813
abnormal hormone level	MPO Gene-Phenotype Associations	1.0	null
FE-64-KC49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.473873
GSE102505_4_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.09481
GSE242199_2_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12179525-mmc1.xlsx-Group_HNF4A_vs_Null_sign-Supplemental_Table_S1_Differentially_expressed_genes_in_HNF4A-transduced_cells_vs_Null_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
Acidocalcisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.924
HSF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1011
hsa-miR-3921	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
hsa-miR-4463	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
HCC-15	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.563
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.16753
GSE188870,GSE188871_0_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Multiple sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.899
ZSWIM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32433
Root tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.287
Arginine	MW Enzyme Metabolite Associations	1.0	null
CRCGN015_HEPG2_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.38523
CACO2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40537
NCIH2405	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39342
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.3529
GSE221327_5_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	174.432
GSE182680,GSE182683_5_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.289
GARIN1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7775
OCIMY5	DepMap CRISPR Gene Dependency	1.0	2.42385
ATAD3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79532
GSE233679_6_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE200352_9_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cellular amino acid metabolic process	GO Biological Process Annotations 2015	1.0	null
abnormal glucose homeostasis	MPO Gene-Phenotype Associations	1.0	null
TEFM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29468
Primary Cholangiocarcinoma Of Intrahepatic Biliary Tract	DisGeNET Gene-Disease Associations	1.0	null
GSE211128_3_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CA1 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.44405
dorsolateral prefrontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.98927
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.302
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.7333
Neurilemmoma	DisGeNET Gene-Disease Associations	1.0	null
GSE199606_1_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SLC16A8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06694
105KC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.64026
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.703
GSE142210_4_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
COA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10401
GSE193258,GSE193259_5_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149903_0_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.097
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.43429
GSE224969,GSE224971_3_v_7_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216043_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE207914_1_v_7_nudt7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.6036
GTEx Heart 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	1.0	8.39324
GSE149359_2_v_1_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_10_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Recurrent Childhood Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
GSE155305_2_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lateral root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.17
Proplastid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.081
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47054
GSE186647,GSE217288_2_v_4_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EA-02-ZO63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21334
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE153871_4_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
posterior hypothalamic area, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.834628
MYSM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.15671
ATF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6258
MCRS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66713
ENO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.08569
RARA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96109
Urease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.908
Metabolism of amino acids and derivatives	Reactome Pathways 2024	1.0	null
DB-34-QA60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.361828
MYOG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.813
Endoplasmic reticulum-Golgi intermediate compartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE146156_1_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EC-01-PH79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262163
CRCGN015_HEPG2_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.389
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-AA_up_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
TXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79591
ZNF274	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5535
GSE227891_5_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
IRF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0186
CRCGN016_MCF10A.TP53.M_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.66657
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
light-harvesting complex, core complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.594
GSE198165,GSE198166_5_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MTO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72943
GSE213588_9_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE235066_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE166315_5_v_3_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF75D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0814
TNFRSF11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87197
GSE171837_3_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
nucleus	GO Cellular Component Annotations 2025	1.0	null
Acute Myocardial Infarction	DisGeNET Gene-Disease Associations	1.0	null
ornithine decarboxylase activity	GO Molecular Function Annotations 2023	1.0	null
negative regulation of protein catabolic process	GO Biological Process Annotations 2025	1.0	null
GSE163862_0_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE198794_2_v_3_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
CHO-MG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.041
positive regulation of biological process	GO Biological Process Annotations 2015	1.0	null
GSE148066,GSE157787_3_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ischemic colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.259
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
skein-like inclusion	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.576
putrescine biosynthetic process from ornithine	GO Biological Process Annotations 2023	1.0	null
GSE142210_11_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Telencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE154961,GSE154963_4_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.62715
PACSIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11053
putrescine biosynthetic process from arginine	GO Biological Process Annotations 2025	1.0	null
GSE199874_4_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH1092	DepMap CRISPR Gene Dependency	1.0	3.35289
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
hsa-miR-4436b-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
PEO4	DepMap CRISPR Gene Dependency	1.0	4.99576
Atg1/ULK1 kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.458
Haustorium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.744
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.0881
K562_Momelotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161524
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.4069
QGP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.975423
PMC9287735-mmc8.xlsx-MI_Related_Genes-TNF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
d5	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.725
THAP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.7319
RCM1	DepMap CRISPR Gene Dependency	1.0	2.2449
ZNF257	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	98.692
GSE102467_1_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormal blood homeostasis	MPO Gene-Phenotype Associations	1.0	null
MFSD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39647
MZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.942989
LXF-289	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.862632
GSE164505,GSE164506_3_v_2_indisulam_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142430_3_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
GSE147366_1_v_0_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.366
TCAIM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3447
Plastid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.692
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.8496
CA-60-LK14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256649
SNRPC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23243
Heart endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.513
KURAMOCHI	CCLE Cell Line Gene CNV Profiles	1.0	1.39146
GSE255680_1_v_0_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE58724_1_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
cytoplasmic vesicle	GO Cellular Component Annotations 2015	1.0	null
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.92387
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.6509
SG in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.66944
FBXO42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52156
duodenum	HPA Tissue Protein Expression Profiles	1.0	1.10356
Motor trigeminal nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.049
CRCGN014_HEPG2_24H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5257
ornithine decarboxylase activator activity	GO Molecular Function Annotations 2025	1.0	null
MSANTD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1068
GSE125219,GSE125221_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RYR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41114
ELF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85758
biological regulation	GO Biological Process Annotations 2015	1.0	null
PMC13127299-mmc2.xlsx-PBX1_kdRNAseq-hgnc_symbol_PBX1	Rummagene Transcription Factor Associations 2026	1.0	null
Midbrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
lateral habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.997768
FD-79-TC61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214101
Tcf21	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.5636
GSE157894_1_v_3_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148066,GSE157787_11_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211989_0_v_1_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HSC4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.56312
ANAPC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07755
HL-60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.23508
LMTK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26289
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.919598
RPS28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17592
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205163,GSE205164_3_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC38	DepMap CRISPR Gene Dependency	1.0	5.00424
GSE185519_3_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ornithine/DAP/Arg decarboxylase	InterPro Predicted Protein Domain Annotations	1.0	null
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.04209
GSE235701,GSE261434_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.34273
CRCGN010_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9428
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.51644
Weight Loss	CTD Gene-Disease Associations	1.0	1.06661
ACBD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77326
cytoplasmic membrane-bounded vesicle	GO Cellular Component Annotations 2015	1.0	null
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.141
abnormal circulating insulin level	MPO Gene-Phenotype Associations	1.0	null
GSE225735_0_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DRAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59609
Tumor Necrosis	DisGeNET Gene-Phenotype Associations	1.0	null
TTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35869
DDI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04298
GSE197850_4_v_2_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BOK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32395
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE131660_2_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.308
CRCGN015_MCF10A.TP53.M_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2218
SG in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0611
GSE149355_0_v_1_esrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211177,GSE211178_8_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180185_4_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
organelle part	GO Cellular Component Annotations 2015	1.0	null
primary visual cortex (striate cortex, area V1/17)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.983719
cingulate gyrus, retrosplenial part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.929574
MDAMB436	DepMap CRISPR Gene Dependency	1.0	2.70344
Thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.46
GSE160373_5_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Erythroleukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE110178_5_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.22065
inferolateral temporal cortex (area TEv, area 20)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11301
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.5716
dorsolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.031
GSE103068_0_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13599
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07995
GSE248935_1_v_0_cd14_human	RummaGEO Gene Perturbation Signatures	1.0	null
PSMA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55069
Focal Nodular Hyperplasia Of Liver	DisGeNET Gene-Disease Associations	1.0	null
Fibroid Tumor	DisGeNET Gene-Disease Associations	1.0	null
XC-81-LR46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.656406
Trichome	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.098
GEMIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39032
GSE216043_10_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.385
TRMT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22304
Respiratory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.505
GSE221577_3_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155916
LPCAT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95875
posterior orbital gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.882613
GSE223008_9_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
negative regulation of protein metabolic process	GO Biological Process Annotations 2025	1.0	null
GSE199606_5_v_7_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE181003_1_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.917114
mitochondrion	GO Cellular Component Annotations 2015	1.0	null
PBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1111
HOP-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09198
GSE126463_6_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NR4A2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3851
GSE196117_6_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.871003
HC-76-HU27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262053
CRCGN009_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16706
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27106
Cytostome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.801
PMC8185471-mmc7.xlsx-DEGs-SOX15_peaks-Day_6_SOX15-_-_upregulated_and_downregulated_genes_nearby_SOX15_CUT_Tag_top_10k_peaks_Related_to_Figure6_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
GSE113106_3_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147876,GSE147877_4_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131161_2_v_6_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Olfactory tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.955
VZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.849192
Zic3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.6189
GSE139016_3_v_2_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE209698_0_v_1_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE188884,GSE189078_2_v_3_ebf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EE-98-PF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314742
ornithine decarboxylase activator activity	GO Molecular Function Annotations 2015	1.0	null
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14247
GSE236502_2_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
CCDC142	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38229
KLHL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86324
Alabastrum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.004
CRCGN017_MCF10A.WT.HP_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.51705
SNRPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3201
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.6604
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5846
Detroit-562 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.959
GSE158431_2_v_3_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HSPA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34311
PSN1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.847079
GSE175787_13_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210663
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.316803
rostral migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.864802
VZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.863341
UTP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31829
GSE148252_5_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:K18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0971
ML-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.26624
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
enzyme activator activity	GO Molecular Function Annotations 2015	1.0	null
BRME1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57963
Helam	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.53
Contractile ring	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.454
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02977
CORL105	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36057
Adult T-cell lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.951
MACIR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.32669
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.271
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5828
HES1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.188
GSE182680,GSE182683_5_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_2_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148066,GSE157787_0_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
network	GeneRIF Biological Term Annotations	1.0	null
KHM-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.95541
GSE70499_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8298
SUPT16H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76573
WDR33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06271
SG in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.40054
K562_SB431542_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162106
GSE223008_11_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244395
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.83414
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Shoot tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.076
ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.849
CDK9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62421
CRCGN014_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8821
GSE151782_1_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KCNS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90481
Carcinoma, Spindle-Cell	DisGeNET Gene-Disease Associations	1.0	null
HOXA10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56835
OSR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3092
Symbiosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.698
MCF7_Ellagic acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160016
GSE156454_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9225
TUBB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25405
GSE166317_3_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.91615
bounding membrane of organelle	GO Cellular Component Annotations 2023	1.0	null
LS123	DepMap CRISPR Gene Dependency	1.0	2.14094
S0-EE-Y6LH_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205833
orbital frontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.947849
GSE125153_2_v_0_bcl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9233
NUP153	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7736
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.81851
FANCE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.622
regulation of catabolic process	GO Biological Process Annotations 2015	1.0	null
OCI-AML5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.3859
GSE221327_5_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
positive regulation of polyamine transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GSE129858,GSE129859_1_v_3_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cell body	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Necrosis	CTD Gene-Disease Associations	1.0	1.14404
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.537247
NCIH1373	DepMap CRISPR Gene Dependency	1.0	3.82609
Progressive Neoplastic Disease	DisGeNET Gene-Phenotype Associations	1.0	null
SFT2D3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95665
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23659
TK-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3238
MEGF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74889
CEP290	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03905
GSE160083,GSE160084_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210101,GSE210114_1_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Unnamed_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
Endoplasmic reticulum-Golgi intermediate compartment membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Seed coat	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.21
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
OECM-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.786
GSE166317_2_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KLF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	109.672
A549_Selisistat_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131119
putrescine biosynthesis II	HumanCyc Pathways	1.0	null
Mesocarp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.752
Learning Disorders	CTD Gene-Disease Associations	1.0	1.08231
JURLMK1	CCLE Cell Line Gene CNV Profiles	1.0	2.10398
GSE149903_6_v_1_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.6004
PIP5K1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26818
Plant vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.28
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2702
gracile nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02806
SYT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83302
MDAMB175VII	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48154
primary auditory cortex (core)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.834176
IZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02875
NCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.39373
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09839
Granular vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.858
GSE88819_7_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111247_11_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62302
JC-63-BE61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285714
GSE222758_0_v_4_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE231799_3_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CE-23-HP88_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.607464
organic cation transport	GO Biological Process Annotations 2015	1.0	null
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A172	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46259
GSE151090_2_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.0964
SK-MEL-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.51734
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TMEM52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09496
SUM 229PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.968201
GSE142210_3_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	118.693
CRCGN013_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7675
GSE134375_6_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_2_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TMEM130	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54881
Flemming body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.07
Root primordium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.924
K562_Entinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021412
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.496
GSE136869_1_v_0_lpar2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cutaneous mastocytosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4417
RAD21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9756
FARAGE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.03453
GSE148692,GSE148695_2_v_6_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MLXIPL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9267
flagtagged	GeneRIF Biological Term Annotations	1.0	null
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.4921
IRS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24812
NR3C2-34362910-WISTARRAT-HIPPOCAMPUS	ChEA Transcription Factor Targets 2022	1.0	null
Cardiac microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.585
negative regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
LNX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35106
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.91475
ETV2::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.5554
A549_Roxadustat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150643
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.08481
FA-80-DR66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20029
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
SMDT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75024
GSE196117_1_v_8_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.112
GPR75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65059
outer CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00878
FOSL1::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.842
RA-42-CM42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262126
GSE226355,GSE226357_1_v_0_ybx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FC-20-EQ58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206103
GSE158632_2_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
Primary root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.938
TRO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34203
GSE114992,GSE114993_7_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
lateral intermediate part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0266
GSE164874_5_v_6_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_3_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Oocyst	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.739
Multiple Chronic Conditions	DisGeNET Gene-Disease Associations	1.0	null
CRCGN008_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.33245
ITGAV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86926
MEIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3782
GSE184475_1_v_0_il21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Adult T-cell lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.118
Human - Tonsil - L2 - PDC	HuBMAP Azimuth Cell Type Annotations	1.0	null
ventrolateral prefrontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.905866
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.848214
Meningioma	DisGeNET Gene-Disease Associations	1.0	null
TC-95-IR96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275649
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
PMC11024925-mmc3.xlsx-Gene_lists-MV411_FOS_ChIP_and_RNA_overlap_after_10_nM_Gilteritinib_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
BTF3L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42139
GSE184902_4_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233647_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.25885
gamete generation	GO Biological Process Annotations 2015	1.0	null
Ulcerative Colitis	DisGeNET Gene-Disease Associations	1.0	null
olfactory part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.947891
DE-97-IV02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266248
GSE239844_4_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.202
TNFAIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47572
MAGOH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85112
Vanishing White Matter Disease	DisGeNET Gene-Disease Associations	1.0	null
GSE204929_0_v_1_ywhag_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MSX2_MSX2	Rummagene Transcription Factor Associations 2026	1.0	null
Secondary Malignant Neoplasm Of Lymph Node	DisGeNET Gene-Disease Associations	1.0	null
TFDP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.9955
regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE100102_0_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211177,GSE211178_4_v_10_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03561
monovalent inorganic cation transport	GO Biological Process Annotations 2015	1.0	null
positive regulation of transmembrane transport	GO Biological Process Annotations 2025	1.0	null
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.891351
Plant bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.056
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1598
SLC30A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.43313
GSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	12.97
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.911
SRXN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43936
MNDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08121
Jejunal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.568
ISOC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94197
T3M4	DepMap CRISPR Gene Dependency	1.0	2.34329
CRCGN008_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2971
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF302	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4329
GSE153064,GSE153065_1_v_2_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216043_7_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Root apical meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.769
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09235
VZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.955884
oculomotor nuclear complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07489
PATZ1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	286.589
Decaprenyl diphosphate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.304
QF-71-QI30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235848
layer IIIu of area 35r	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.46461
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.63345
Granular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
DBP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.3338
gonadal	GeneRIF Biological Term Annotations	1.0	null
EE-08-SZ54_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239711
CRCGN014_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00706
hippocampus (hippocampal formation)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.908294
endogenous	GeneRIF Biological Term Annotations	1.0	null
ABCC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57807
YMB1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39836
Metastatic Urothelial Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
2907_FAM216A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.629067
GSE110178_1_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
VZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.31258
GSE207863_0_v_1_hdac5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.335529
GSE164874_5_v_10_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-3665	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
dendrite	GO Cellular Component Annotations 2015	1.0	null
GSE139016_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
SCaBER cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.536
Myocardial Infarction	DisGeNET Gene-Disease Associations	1.0	null
GSE221327_5_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140997_4_v_3_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE224311_3_v_1_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RIC8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28674
localization	GO Biological Process Annotations 2015	1.0	null
Anal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
CRCGN017_MCF10A.WT.HP_24H:E14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4778
GSE114258_1_v_0_foxk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ALKAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84992
SIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56181
GSE225218_9_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Chloroplast photosystem II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.013
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.992343
SMARCB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.57934
Vestibular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.793
GSE147876,GSE147877_2_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
appears	GeneRIF Biological Term Annotations	1.0	null
GSE182680,GSE182683_0_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
callosal sling	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.952044
GSE213588_9_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SK-N-FI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.927085
GSE157233_2_v_4_a1cf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111247_2_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Glutamate decarboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.805
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31071
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.855402
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE168797_4_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_12_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
interferon-mediated signaling pathway	GO Biological Process Annotations 2025	1.0	null
Myosin VI complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.252
GATB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91885
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178255_1_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
ZNF530	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.3731
RSPRY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66068
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.933262
BXPC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.871175
frontal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.967032
enzyme regulator activity	GO Molecular Function Annotations 2015	1.0	null
GSE140997_2_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary amino compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE229468,GSE229471_2_v_3_znf587_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE117042_0_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PROX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26701
PMC12152148-41420_2025_2541_MOESM3_ESM.xlsx-AR-IP-DHT_peak-gene-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8841363__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Seh1-associated complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.032
GRHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.7588
CRCGN016_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.62245
membrane	GO Cellular Component Annotations 2015	1.0	null
GSE242199_9_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU626	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32219
CRCGN015_HEPG2_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0302
POM121C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.44354
SG in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3843
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.952357
Transport vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
odc	GeneRIF Biological Term Annotations	1.0	null
GSE228413_4_v_1_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.898223
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9919
GSE189789_0_v_1_oridonin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ornithine decarboxylase activator activity	GO Molecular Function Annotations 2023	1.0	null
NSRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53909
GSE110178_1_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151494_1_v_9_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08041
GSE218060_2_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242199_6_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
outer CP in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.933803
CAMK2N1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4047
HS 895.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.898366
GSE149124,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Edinger-Westphal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02433
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MSX1_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE87617_1_v_0_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	95.0909
Alx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.1835
Nfatc1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.4812
regulation of catalytic activity	GO Biological Process Annotations 2015	1.0	null
GSE149901_2_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TFAP4::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.6951
PLP-binding barrel	InterPro Predicted Protein Domain Annotations	1.0	null
trans-Golgi network	GO Cellular Component Annotations 2025	1.0	null
ventrolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16598
Cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.721
CRCGN011_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3443
IZUMO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4506
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24976
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.579
GSE164483_2_v_0_venetoclax_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.46674
IFIT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15877
posterior (caudal) superior temporal cortex (area 22c)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08245
GSE147943_2_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Macula densa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.593
CRCGN016_MCF10A.TP53.M_24H:D18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75091
GCM2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2277
single organism reproductive process	GO Biological Process Annotations 2015	1.0	null
ZBTB7A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.275
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.395
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.465
NCIH2452	DepMap CRISPR Gene Dependency	1.0	3.46998
KMS-26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.975423
homeostasis/metabolism phenotype	MPO Gene-Phenotype Associations	1.0	null
GSE183251_1_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF93	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	144.185
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.68505
Hepatoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE212486,GSE212488_0_v_1_gata4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Root quiescent center	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.563
Phagophore assembly site membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.802
PRDM8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32539
GSE81193_1_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCFL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.7393
GSE190322,GSE190324_3_v_4_rbm4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199255,GSE199356_6_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Chloroplast thylakoid membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.905
GSE160246_0_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE144231_4_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84337
GSE162892_3_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Diabetes	DisGeNET Gene-Disease Associations	1.0	null
A549_GSK-LSD1 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015122
GSE166315_5_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AC-28-RT00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239025
BEND5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51535
CRCGN008_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1058
carboxylic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.88415
GSE133087_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
GSE100102_4_v_3_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Intraocular Retinoblastoma	DisGeNET Gene-Disease Associations	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.984545
Trophectoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.422
anion transport	GO Biological Process Annotations 2015	1.0	null
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8497824-Table_4.xlsx-Stage_4_EOMES_vs_Ctrl-Unnamed_1_EOMES	Rummagene Transcription Factor Associations 2026	1.0	null
trans-Golgi network	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20677
GSE142210_4_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_13_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
IZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.866434
GSE195582_3_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.871175
GSE115395_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Alzheimer Disease	DisGeNET Gene-Disease Associations	1.0	null
TCERG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95071
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.47648
GSE182727_1_v_0_busulfan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RPS6KA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04658
GSE148066,GSE157787_8_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HC-01-FD24_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215131
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6012
CRCGN010_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4391
transporter activity	GO Molecular Function Annotations 2015	1.0	null
IRF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.2488
TNPO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25744
GSE152432_3_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
posteroventral (inferior) parietal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.874695
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.48028
RGS19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83129
arginine decarboxylase activity	GO Molecular Function Annotations 2023	1.0	null
ME-31-RM40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205084
hsa-miR-153	TargetScan Predicted Conserved microRNA Targets	1.0	0.23348
BA-69-TQ80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.375926
MRPL22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46812
putrescine biosynthetic process	GO Biological Process Annotations 2023	1.0	null
Lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.505
Amyotrophic Lateral Sclerosis	DisGeNET Gene-Disease Associations	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.12391
M6PR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98764
PPP1CC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38576
TOB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11769
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.511611
NCI-H520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.883376
NTERA2CLD1	DepMap CRISPR Gene Dependency	1.0	2.85855
Surgically-Created Resection Cavity	DisGeNET Gene-Disease Associations	1.0	null
post-anaphase microtubule array	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.763
regulation of polyamine transmembrane transport	GO Biological Process Annotations 2025	1.0	null
A549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04236
GSE121198,GSE129782_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.348993
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Diamine N-acetyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.226
Hepatoma ascites cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.722
Plantlet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.25
anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.6322
Leydig Cell Tumor	DisGeNET Gene-Disease Associations	1.0	null
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
STAC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32101
7527_RPS5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.08948
PMC8047323-Table_2.xlsx-LPS_PMMA_T24-GeneSymbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE145171_0_v_1_prox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HKA1	DepMap CRISPR Gene Dependency	1.0	2.26912
NP2	DepMap CRISPR Gene Dependency	1.0	2.19111
A549_Pracinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0105174
PLAA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84554
Yae1-Lto1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.088
HD-62-KE69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.342415
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.35
MLLT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75645
GSE81803,GSE81912_3_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112763,GSE112767_4_v_5_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TRIM21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96355
LOX-IMVI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.089
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06134
CHD4-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1563
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.062
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0321
GSE216147_2_v_1_rbm20_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20146
GSE147943_5_v_1_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199606_5_v_7_csf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BE-17-CS60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227193
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.75497
GSE102505_1_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
trans-golgi network	GO Cellular Component Annotations 2015	1.0	null
Spikelet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.46
intracellular part	GO Cellular Component Annotations 2015	1.0	null
Brain Abscess	DisGeNET Gene-Disease Associations	1.0	null
Orn/DAP/Arg decarboxylase 2, C-terminal	InterPro Predicted Protein Domain Annotations	1.0	null
High Grade Glioma	DisGeNET Gene-Disease Associations	1.0	null
neuron projection	GO Cellular Component Annotations 2015	1.0	null
GSE149621_2_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.333
localize	GeneRIF Biological Term Annotations	1.0	null
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234123
CE-18-CG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23938
DOCK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41912
AC-30-XU83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244426
GSE198165,GSE198166_5_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ornithine decarboxylase regulator activity	GO Molecular Function Annotations 2015	1.0	null
bounding membrane of organelle	GO Cellular Component Annotations 2025	1.0	null
Photosystem II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.384
Zymogen granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.553
GSE221577_4_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Hyperargininemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
GSE235120_1_v_0_pidd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264496
ERF::NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.6502
EVSAT	DepMap CRISPR Gene Dependency	1.0	8.35042
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7789
GSE166944_0_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
associate	GeneRIF Biological Term Annotations	1.0	null
GSE140607_1_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
central nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.837889
GSE182680,GSE182683_0_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
orbital frontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09377
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SG in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.14848
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.24112
GSE140441_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
IGSF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.37193
B4GALT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70371
GTEx BloodVessel 20-29 vs 40-49	GTEx Tissue-Specific Aging Signatures	1.0	6.81527
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.902809
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.032
hsa-miR-4653-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23986
GSE149903_3_v_1_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAD2L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.44928
GSE195568_3_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3M_Peaks_YAP1MAMLD1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE189653,GSE203344_5_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Nitrate reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.636
cis-Golgi network	GO Cellular Component Annotations 2023	1.0	null
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.28895
nucleus	GO Cellular Component Annotations 2015	1.0	null
Myocardial infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.144
ZNF281	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	281.671
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.28005
PTPN13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98953
ULK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67725
CRCGN015_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17945
IkappaB kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.869
DCLK1+ progenitor cell_Large intestine_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsal thalamus_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.824747
primary auditory cortex (core)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1677
NFIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.8981
axon	GO Cellular Component Annotations 2025	1.0	null
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.2712
ventrolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.75269
PAPOLB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86258
GSE182680,GSE182683_5_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cervicovaginal fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.674
GSE242199_6_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_UNC1999_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199479
CRCGN012_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2353
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE128730_3_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.6268
Agenesis	DisGeNET Gene-Disease Associations	1.0	null
Vdr	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.6242
Adult Ependymoma	DisGeNET Gene-Disease Associations	1.0	null
GSE136894_2_v_3_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_12_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Malignant Bone Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
K562_UNC1999_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187251
Metabolism of amino acids and derivatives	Reactome Pathways 2014	1.0	null
GSE130690,GSE130692_2_v_0_sirt6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.431
COX7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85746
single-organism process	GO Biological Process Annotations 2015	1.0	null
GSE198165,GSE198166_9_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cytomegalovirus Encephalitis	DisGeNET Gene-Disease Associations	1.0	null
HSF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.6374
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4532
GSE194396,GSE194429_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.56
GSE223008_6_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE168401_2_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
IHF-DNA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.62
GSE192689_0_v_2_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.5887
regulation of transport	GO Biological Process Annotations 2015	1.0	null
HBA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58887
GSE100316_7_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HES5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5117
NEUROD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57225
GSE114992,GSE114993_7_v_10_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10063
CE-95-YX02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256537
GSE63048_11_v_6_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
STAT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.4141
GSE111247_0_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.473256
KIAA0753	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38255
Endoplasmic reticulum-Golgi intermediate compartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.455
POU2F1::SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3608
GSE138019_1_v_5_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SG in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.68119
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.35738
ZBED6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16762
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.17
GSE145639_7_v_4_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
OC-71-BZ81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200642
SLC22A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71729
GSE130956_0_v_3_icaritin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10330983-ab-22-0432-Supplementary-Table-10.pdf-30-ATF6_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE139966_1_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229973_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PARK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67561
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	150.27
TMEM249	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7241
SOD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61372
GSE233548_2_v_0_plscr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4649-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Secondary Malignant Neoplasm Of Liver	DisGeNET Gene-Disease Associations	1.0	null
Glutamate synthase complex (NADPH)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.431
Trypanosomiasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.309
Vegetative stage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.724
HCC1937	DepMap CRISPR Gene Dependency	1.0	2.19833
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.898223
ZNF341	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.5069
GSE248887_0_v_1_dkk1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Plastid thylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.958
mitochondrion	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE184892_4_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE166920_6_v_2_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H727	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.871003
HD-29-LW24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210278
GSE198165,GSE198166_8_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Supplementary_Table_9A_The_effects_of_whole_blood_transcripts_on_COVID-19_severity_with_suggestive_Mendelian_randomization_evidence_P_0_05_using_Genomicc_data_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE114992,GSE114993_0_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cortical microtubule cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.583
GSE151612_0_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20605
Tumor Progression	DisGeNET Gene-Phenotype Associations	1.0	null
Pilocytic Astrocytoma	DisGeNET Gene-Disease Associations	1.0	null
Axillary bud meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.592
Secondary root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.084
NCI-H2126	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19028
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.921368
GSE210377_0_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
posteroventral (inferior) parietal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.31463
MHH-NB-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.157
GALNT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8805
GSE140997_10_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site	InterPro Predicted Protein Domain Annotations	1.0	null
CRCGN015_HEPG2_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.009
RBM48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34538
Ebf4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	41.5362
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.992343
GSE182680,GSE182683_0_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5095001-oncotarget-07-36293-s002.xlsx-Table_S2-Table_S2_MYCN-correlated_genes_and_their_correlations_with_other_transcription_factors_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
Intrahepatic Cholangiocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE221327_4_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_MC1568_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187902
nasopharynx	HPA Tissue Protein Expression Profiles	1.0	1.10356
GSE160373_6_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
anion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
CRCGN010_HEPG2_24H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07269
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE224877_3_v_0_pctp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_11_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE166315_5_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119978,GSE180930_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
JHUEM1	DepMap CRISPR Gene Dependency	1.0	4.38554
GSE134375_6_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
ETV2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.2354
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203534
biological_process	GO Biological Process Annotations 2015	1.0	null
positive regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
FA-10-SN61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272774
GSE211226_1_v_0_sirpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-4763-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE101112_0_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0233
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.324
vesicles	GeneRIF Biological Term Annotations	1.0	null
nb88	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.45
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	95.8256
GSE99687_3_v_1_smad5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.202
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.01645
SMAD5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2472
BET1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62185
BF-94-CQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210612
Cornu ammonis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.86
NAXE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.59537
interleukin-28 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.586
Basal ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE231720,GSE231724_3_v_0_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZFX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91446
Proteinuria	CTD Gene-Disease Associations	1.0	1.02188
C2BBE1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.6117
T-84 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.695
Inflammation	CTD Gene-Disease Associations	1.0	1.19835
hsa-miR-4781-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.37496
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
Non-Small Cell Lung Cancer	DisGeNET Gene-Disease Associations	1.0	null
GSE145445,GSE145454_0_v_1_cop1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
C2CD4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27302
TIMM10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03412
NRTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38062
outer CP in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10712
GSE146612_1_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE100102_4_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10973
GSE146074_9_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8483
GSE164874_5_v_3_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sepal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.529
ZFR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57356
CORL24	CCLE Cell Line Gene CNV Profiles	1.0	2.59945
PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-SP1_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.46637
ZBED2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0039
GSE228413_0_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pelvic Insufficiency Fracture	DisGeNET Gene-Disease Associations	1.0	null
positive regulation of catalytic activity	GO Biological Process Annotations 2015	1.0	null
GSE232631_5_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BA-86-AL61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210819
SUP-B15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.15136
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.383551
GSE100316_5_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.077
rt1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.878
EXTL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01755
GSE186223,GSE186224_6_v_3_hmces_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-46-GL76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.368026
GGH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91359
LCAM1	DepMap CRISPR Gene Dependency	1.0	4.51561
GSE140651,GSE140653_2_v_4_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149903_0_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNUC5	DepMap CRISPR Gene Dependency	1.0	3.65905
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	46.4918
GSE255680_2_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
superior rostral gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02568
Leukemia	DisGeNET Gene-Disease Associations	1.0	null
MPND	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.1597
Melanoma	DisGeNET Gene-Disease Associations	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_U87MG_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE155305_3_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE188869,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1102
PAFAH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82456
MEL-745A cl. DS19 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.516
PIM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09375
CRCGN015_MCF10A_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.70095
NDUFA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81253
CRCGN017_MCF10A.WT.HP_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21275
GSE226249_2_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Adenocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.889728
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.42295
GSE146982_4_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE199255,GSE199356_0_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NUP205	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59674
membrane organization	GO Biological Process Annotations 2023	1.0	null
AE-85-KE62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.339652
PKNOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.1377
PMC11067031-pnas.2317690121.sd06.xlsx-gene_list_14_txt-Differentially_expressed_genes_between_PML_RARA_GFP_vs_C88A_PML_RARA_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07256
NCOA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8971
Radicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.269
posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.66667
ammonium transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
pontobulbar body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.859622
membrane organization	GO Biological Process Annotations 2015	1.0	null
GSE130383_2_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Apical meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.064
Stat2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	93.7055
Macular Edema, Cystoid	DisGeNET Gene-Disease Associations	1.0	null
GSE124410_6_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146612_2_v_0_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152666,GSE152668_2_v_1_carm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PFDN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25441
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.884889
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06274
primary motor cortex (area M1, area 4)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1393
transport	GO Biological Process Annotations 2015	1.0	null
CDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62242
GSE162087_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SELENOM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40963
cellular component organization	GO Biological Process Annotations 2015	1.0	null
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205163,GSE205164_1_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.872741
EC-01-PH79_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.377484
BE-17-CS60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.366955
Primary Central Nervous System Lymphoma	DisGeNET Gene-Disease Associations	1.0	null
SLC25A38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84604
GSE205976,GSE205978_3_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3K_Peaks_wtYAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
whereas	GeneRIF Biological Term Annotations	1.0	null
RKN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.15313
CIAO2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04757
Mesocotyl	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.107
A549_KW-2449_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126179
HOXD9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3494
Human - Tonsil - L2 - PDC_multiome	HuBMAP Azimuth Cell Type Annotations	1.0	null
NCIH1373	CCLE Cell Line Gene CNV Profiles	1.0	1.33532
GSE174383_1_v_5_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
inorganic anion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GSE110178_5_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.296
Bacteroid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.775
QB-99-OU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220656
glycine-gated chloride channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.954
C3orf18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45239
K562_S3I-201_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180257
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.31689
GSE199255,GSE199356_4_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Childhood Ependymoma	DisGeNET Gene-Disease Associations	1.0	null
Glutamate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.349
Enhanceosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.198
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.2909
ornithine metabolic process	GO Biological Process Annotations 2023	1.0	null
GSE226249_5_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1d-List_of_2302_of_genes_differentially_regulated_by_SOX2_FDR_0_1_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.018
GSE254517_3_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE197555_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_4_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.32512
GSE183251_1_v_5_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225662
Polyketide synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.089
cellular biogenic amine biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Pericarp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.845
establishment of localization	GO Biological Process Annotations 2015	1.0	null
carbamoyl-phosphate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.761
Axon	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PKD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11358
GSE131887_1_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE150072,GSE169209_6_v_9_qser1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE188870,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0282
GSE105169,GSE105175_0_v_1_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
MYBPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83288
CRCGN008_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3998
ATP6V1B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16424
Liver Regeneration Disorder	DisGeNET Gene-Phenotype Associations	1.0	null
ZC3H8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02349
ventrolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.894737
bounding membrane of organelle	GO Cellular Component Annotations 2015	1.0	null
Nr2e1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.5884
ZNF593	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84645
GSE163920_1_v_0_sirt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NE-37-BQ24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219589
Neuroblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201146
Nrf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	82.5601
SR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.22945
KYSE30	DepMap CRISPR Gene Dependency	1.0	2.66052
YSCCC	DepMap CRISPR Gene Dependency	1.0	2.71549
CENPM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29808
Spinal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.106
Orn/DAP/Arg decarboxylase 2, N-terminal	InterPro Predicted Protein Domain Annotations	1.0	null
ELP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72843
CRCGN015_MCF10A_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03997
GSE101336_1_v_0_decitabine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_10_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE225141,GSE225143_2_v_3_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Mesna_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182773
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-d-Classification_of_camel_SON_basal_genes_-_enzymes_SON	Rummagene Transcription Factor Associations 2026	1.0	null
primary motor cortex (area M1, area 4)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.978953
KCTD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50772
GSE100316_7_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE200352_11_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CA46	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.88907
GSE70499_3_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE138050,GSE148257_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.7326
GSE196117_6_v_8_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MECR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30218
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.96812
Perirhinal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.667
upper (rostral) rhombic lip_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.37981
Foot sole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.834
GSE213632_1_v_5_acod1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GORASP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.89174
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.28758
GSE111247_2_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
DQX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10017
GSE228181_4_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PRIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19199
BHLHE22	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9228
TMEM120B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30723
GSE190534,GSE190536_0_v_2_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Leaf lamina	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.599
GSE123502,GSE123504_1_v_0_chd4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FA-63-WI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286514
HDAC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.61598
Cytosol	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.077
MCF7_Divalproex Sodium_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013054
GSE172295_3_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07995
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.316
BICR 10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.973264
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.917114
TIG-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.766
Axillary bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.537
SNU-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.62152
GSE247862,GSE247863_0_v_3_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GP1BA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40299
involvement	GeneRIF Biological Term Annotations	1.0	null
ZBTB33	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.5901
GSE111102,GSE111105_4_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216043_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Organelle subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
SNU-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.840534
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.505
TFAP4::ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.9308
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.98611
GSE217156_1_v_3_trpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_U87MG_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Prenatal Injuries	CTD Gene-Disease Associations	1.0	1.01512
CRCGN016_MCF10A.TP53.M_24H:M19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28462
GSE97352_1_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
upper (rostral) rhombic lip_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19151
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226249_0_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Somatodendritic compartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
synthesis	GeneRIF Biological Term Annotations	1.0	null
cation transport	GO Biological Process Annotations 2015	1.0	null
GSE179031_3_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203655_0_v_1_stat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217873_1_v_2_nusap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_3_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149903_6_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38484
SK-MEL-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06722
AA-86-YY62_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.293915
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_MC1568_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145773
GSE203158_0_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
primary motor cortex (area M1, area 4)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17323
multicellular organismal reproductive process	GO Biological Process Annotations 2015	1.0	null
GSE246911,GSE246913_4_v_1_arid1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ion transport	GO Biological Process Annotations 2015	1.0	null
GSE217541,GSE217543_3_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.363437
jm2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.71
Recurrent Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
dorsolateral prefrontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.886463
GSE114284_1_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186660_2_v_1_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.74859
GSE118816_2_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF324	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.589
OSR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.8851
VZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.68822
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.695
GSE70499_5_v_1_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Stele	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.44
GSE240645_1_v_0_u90926_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
steroid	GeneRIF Biological Term Annotations	1.0	null
ubiquitindependent	GeneRIF Biological Term Annotations	1.0	null
SP in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.24865
EIF1AD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.13206
WSU-NHL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.940763
regulation of protein metabolic process	GO Biological Process Annotations 2015	1.0	null
CA3 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.906208
Neurofibroma	DisGeNET Gene-Disease Associations	1.0	null
GSE179002_2_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248045,GSE248046_0_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Branch	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.793
VPS37A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35111
SNU-719	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.23508
outer CP in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05205
GSE223008_9_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169356_0_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormal circulating hormone level	MPO Gene-Phenotype Associations	1.0	null
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1605
GSE101537_1_v_2_neurog3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149903_4_v_1_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYOZ3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3112
BCPAP	CCLE Cell Line Gene CNV Profiles	1.0	1.53246
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FB-32-PY27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242585
NTF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.69082
USF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66119
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE228413_4_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226249_2_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
outer plexiform zone in extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.7506
MZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14366
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Metabolism of polyamines	Reactome Pathways 2014	1.0	null
SNU5	DepMap CRISPR Gene Dependency	1.0	2.44912
GSE136232,GSE136234_0_v_1_zpbp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
MTMR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83544
GSE189859,GSE189861_1_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Toe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.119
cellular response to type I interferon	GO Biological Process Annotations 2025	1.0	null
GSE127790_13_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cytosol	GO Cellular Component Annotations 2015	1.0	null
SCC-15 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.643
cerebellum	HPA Tissue Protein Expression Profiles	-1.0	-1.17543
ACSM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75336
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.053
EPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22402
Carney Complex	DisGeNET Gene-Disease Associations	1.0	null
CDC5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63376
linked	GeneRIF Biological Term Annotations	1.0	null
PLPP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51489
SMCR8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31042
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204783
Small intestine cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.682
624 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.904604
HCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27943
UBAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32584
PTER	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77138
GSE122101,GSE122103_0_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149901_3_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE104022_3_v_4_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
mainly	GeneRIF Biological Term Annotations	1.0	null
Chloroplast thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.852
GSE174701_5_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Thylakoid light-harvesting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.784
A549_FLLL32_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121271
GSE139966_4_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE86507,GSE86509_3_v_9_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.02735
PRKAG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64943
monovalent inorganic cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GSE232218_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_12_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perinuclear region of cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Guanylate cyclase complex, soluble	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.887
OVCAR433	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47054
PMEPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67919
GSE192663_1_v_5_acly_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5007
GSE114992,GSE114993_4_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH2081	CCLE Cell Line Gene CNV Profiles	1.0	1.65862
GSE120756_2_v_9_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Oxyntic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.923
GSE144919,GSE145177_1_v_0_dazl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Retinoblastoma	DisGeNET Gene-Disease Associations	1.0	null
SS18L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6361
GSE168171,GSE168173_0_v_1_ddx41_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.154
Bladder Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
HT144SKINFV1	DepMap CRISPR Gene Dependency	1.0	2.18313
Neonatal Pneumonia	DisGeNET Gene-Disease Associations	1.0	null
DYNLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26386
GSE153867_6_v_3_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GATA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1095
OLFML2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54889
SF767	DepMap CRISPR Gene Dependency	1.0	3.09212
INSM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.6667
NEURL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86636
Ebf2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.1309
MROH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87035
PABPC1L2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01154
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.872554
GSE223008_7_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE198165,GSE198166_6_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Uterine epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.604
CRCGN014_HEPG2_3H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13336
GSE210150_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE139239_1_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC2A14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9788
GSE166315_1_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.70914
RELCH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2816
CDPF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67608
small molecule metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GE-63-WI86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231016
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.16639
Trigeminal Neuralgia	DisGeNET Gene-Disease Associations	1.0	null
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.1247
DCAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90521
cis-Golgi network	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
PMC9218734-Supplementary_Data3.xlsx-KRIEG-KRIEG_HYPOXIA_NOT_VIA_KDM3A_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
Nfe2l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.7466
GSE82032_3_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1858
CNNM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33087
KLF14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	163.142
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.940045
Squamous Cell Carcinoma Of Esophagus	DisGeNET Gene-Disease Associations	1.0	null
ZFP14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	142.7
K562_AG-490_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016067
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.85
GSE102467_1_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
positive regulation of transmembrane transport	GO Biological Process Annotations 2015	1.0	null
C2BBE1	DepMap CRISPR Gene Dependency	1.0	2.61867
inferolateral temporal cortex (area TEv, area 20)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0163
GSE106661,GSE106665_0_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213632_3_v_6_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RFX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.3215
CRCGN015_MCF10A.WT.HP_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.53927
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.318
regulation of localization	GO Biological Process Annotations 2015	1.0	null
RMSYM	DepMap CRISPR Gene Dependency	1.0	3.89043
UTP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25922
GSE228413_2_v_5_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_5_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
amygdaloid complex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.984838
SG in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.50457
UTP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.012
Stolon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.832
CA1 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.995747
GATA1::TAL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1883
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.21567
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27106
Xenopus A6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.817
GSE178340_5_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8288_SOX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.537038
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	50.5604
GSE135514_2_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE120413,GSE120447_3_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FUOM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.36677
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3N_Peaks_YAP1FAM118B_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119564_2_v_0_zfp217_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ATP2C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73711
Agmatine biosynthesis	Reactome Pathways 2024	1.0	null
MIA PACA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11981
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1746
GSE205976,GSE205978_1_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Claw	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.242
GSE153064,GSE153065_1_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223241_2_v_0_cdkn2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CDCP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09751
ZNF615	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48204
GSE87412,GSE92423_3_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BE-82-TS38_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204765
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.883138
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223008_5_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
C6orf47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67016
ETV5::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8109
ZCCHC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50816
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN011_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17905
Nasopharyngeal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
carboxy-lyase activity	GO Molecular Function Annotations 2025	1.0	null
MCF7_Mocetinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00877175
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
Plagl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.1652
Pith	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.921
granular vesicle	GO Cellular Component Annotations 2025	1.0	null
orbital frontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.926058
K562_Celecoxib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016308
GSE205163,GSE205164_1_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LUBAC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.48
Shox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.9416
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.6811
ATP5MG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15039
Infertility, Male	CTD Gene-Disease Associations	1.0	1.20493
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9013
ARL14EP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81153
Orn/DAP/Arg decarboxylase 2, conserved site	InterPro Predicted Protein Domain Annotations	1.0	null
BE-27-RQ61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.386649
MAFG::NFE2L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.3936
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.29513
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.320193
Brain stem	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE178714_3_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Uterine epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.004
cellular nitrogen compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
JURKAT, CLONE E6-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
regulation of primary metabolic process	GO Biological Process Annotations 2015	1.0	null
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.450342
RBIS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58344
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.340663
GSE65617_5_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204544
CRCGN015_MCF10A.TP53.M_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9068
alpha-amino acid metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE149075_1_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CHLA90	DepMap CRISPR Gene Dependency	1.0	2.0789
SNAI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97278
GSE124920_1_v_2_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH209	CCLE Cell Line Gene CNV Profiles	1.0	2.36179
ZNF648	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11191
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.26568
substrate-specific transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GSE164757,GSE164759_1_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE228727_2_v_0_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE198165,GSE198166_0_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HC-11-RK51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307274
CRCGN015_HEPG2_48H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5282
SKNBE2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54053
Childhood Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
Thylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.55
TSG101	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08244
VILL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82514
MOLP-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.962813
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.858326
cellular component organization or biogenesis	GO Biological Process Annotations 2015	1.0	null
ARHGEF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87788
Hand1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	42.5603
GSE118794_0_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GE-25-DQ65_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243674
Leukoencephalopathy	DisGeNET Gene-Disease Associations	1.0	null
putrescine transport	GO Biological Process Annotations 2015	1.0	null
Chronic obstructive pulmonary disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.505
GSE195663_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DMS79	CCLE Cell Line Gene CNV Profiles	1.0	1.34626
SP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	154.233
KLHL26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50175
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.92323
ZNF511	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42208
GSE77108_0_v_7_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
VZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.36702
VZ in midcingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.80555
Ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Sleeping sickness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.265
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-WT-gene_symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF701	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.7406
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ACAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.36519
GSE160373_1_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CFAP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48714
Citrullinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
Chloroplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.606
LSG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25088
Plant primordium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.615
CCDC184	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17139
Squamous Cell Carcinoma Of Oropharynx	DisGeNET Gene-Disease Associations	1.0	null
NDUFA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66123
GSE221327_4_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12951
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	106.892
FOXO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23742
GSE221356_1_v_0_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE114992,GSE114993_9_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147943_4_v_6_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE240896,GSE240899_3_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
UF-14-LK87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.378433
GABRB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.52313
CDC73	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44935
NT5DC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.68638
GSE205163,GSE205164_1_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Zfp809	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.0907
CA4 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.879838
GSE206729_2_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5976
DDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48121
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.60094
GSE226584,GSE226589_2_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111102,GSE111105_1_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.18434
BATF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08171
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.84763
CRCGN015_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.9704
GSE148252_5_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114013,GSE114014_0_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE164874_5_v_4_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-circARID1A_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE141328_3_v_2_rock2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
decreased circulating insulin level	MGI Mouse Phenotype Associations 2023	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
trans-Golgi network membrane organization	GO Biological Process Annotations 2025	1.0	null
amygdaloid complex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00345
GSE232631_5_v_2_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CHST4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46199
dendrite	GO Cellular Component Annotations 2025	1.0	null
GSE205163,GSE205164_2_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131425_2_v_3_arg2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE122101,GSE122103_3_v_4_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZR751	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40135
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
GSE102505_4_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Endosperm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.105
CXCL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52706
GSE183994_3_v_0_scml2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9170821-JCMM-26-3183-s001.xlsx-Mic_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
CEP68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30588
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17661
Metastatic Malignant Neoplasm To Brain	DisGeNET Gene-Disease Associations	1.0	null
GSE157960_2_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE122711_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
upper (rostral) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.60967
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2459
GSE254517_1_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168797_1_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223008_6_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.97284
GSE117042_1_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.27634
GSE171837_3_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ISHIKAWAHERAKLIO02ER	DepMap CRISPR Gene Dependency	1.0	3.23715
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20677
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20568
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.98065
GSE233647_2_v_3_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_9_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF358	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73915
GSE182181_1_v_0_ricolinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
ovary	HPA Tissue Protein Expression Profiles	-1.0	-1.17543
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233377
GSE124410_2_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145639_1_v_4_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Gerontoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.596
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14513
Glume	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.535
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.3182
GSE103297_1_v_0_glis3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.33343
GSE102505_6_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Leiomyosarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.558
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135030_11_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FA-52-OO58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242094
Leaf bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.967
STAT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.137
PHYKPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.79277
GSE207514,GSE207515_1_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178255_2_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BCL7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94858
Oral squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.895
Stem cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.209
Helicobacter Pylori (H. Pylori) Infection In Conditions Classified Elsewhere And Of Unspecified Site	DisGeNET Gene-Disease Associations	1.0	null
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE218727_2_v_1_zkscan3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE162892_3_v_0_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
BC-63-DM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.280483
UKE-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.4737
Spinal trigeminal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.936
TMEM43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21489
organelle	GO Cellular Component Annotations 2015	1.0	null
GSE202434,GSE202438_15_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE174735_1_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11242
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
Glyoxysome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.967
GSE138863_3_v_0_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.92323
LMBRD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87378
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
tak3	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.259
PCI6A	DepMap CRISPR Gene Dependency	1.0	5.92992
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Chagas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.073
GSE179693,GSE179694_4_v_2_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
SG in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30493
GSE199899_1_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Internode	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.448
GSE157262,GSE157268_3_v_0_ythdc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160246_0_v_7_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114992,GSE114993_1_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178255_5_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.82402
TGFBRAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75663
abnormal homeostasis	MPO Gene-Phenotype Associations	1.0	null
Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	44.0264
positive regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8919
Immunosuppression	DisGeNET Gene-Disease Associations	1.0	null
NCI-H2795	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00362
IRF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.5
GSE158431_2_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205316,GSE205317_0_v_1_nrip1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ABCG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35916
BC-01-JL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.33515
polyamine biosynthetic process	GO Biological Process Annotations 2015	1.0	null
SH2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37463
7524_RPS3_P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.544971
GSE125211_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.315917
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.45424
GSE126463_1_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOS::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2767
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.31176
CRCGN009_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.27535
Gastric gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.904
labile	GeneRIF Biological Term Annotations	1.0	null
CRCGN017_MCF10A.WT.HP_24H:E04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.25547
2545_EIF3B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.528996
MARK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.761
Coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.148
TBXT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.5908
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.4737
Autoimmune disease of central nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.888
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21078
Dlx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.4768
GSE70499_3_v_6_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CA4 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.953169
PSN1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.67921
regulation of molecular function	GO Biological Process Annotations 2015	1.0	null
CRCGN012_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01134
Edinger-Westphal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.391
hsa-miR-448	TargetScan Predicted Conserved microRNA Targets	1.0	0.226173
PI4K2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70991
GSE142210_2_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.646
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206697
GSE169697,GSE169725_0_v_5_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE123825_2_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.58275
Hypertension	HuGE Navigator Gene-Phenotype Associations	1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.263
GSE136894_1_v_3_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UM-UC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.870074
plant-type vacuole membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.812
GSE124410_6_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CC-68-YZ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.337007
Obstructive lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.505
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.21512
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
IRF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6615
K562_Mocetinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154734
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.16419
PCDHB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78783
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.912063
primary amino compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CENPW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82464
GSE133763_0_v_2_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE150215_1_v_2_etl4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-58-FJ71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.342095
GSE236262_0_v_3_trim28_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TRAPPC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42318
posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07142
preoptic region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.987867
CRCGN017_MCF10A.WT.HP_24H:O17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02765
Acute Pancreatitis	DisGeNET Gene-Disease Associations	1.0	null
Primary Malignant Neoplasm Of Lung	DisGeNET Gene-Disease Associations	1.0	null
GSE140997_2_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GLRX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60628
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135514_2_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Coleoptile	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.246
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203486
AKIRIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23497
IZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.98562
hippocampus (hippocampal formation)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.989379
perinuclear region of cytoplasm	GO Cellular Component Annotations 2015	1.0	null
PCI30	DepMap CRISPR Gene Dependency	1.0	5.89333
ABCB8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94365
SLR24	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53626
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-0.847282
GSE175787_11_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
TCF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.552
GSE112761,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PNN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61289
GSE135030_11_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC827	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.979682
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.3908
SETD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73004
GSE146982_7_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GINM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.453
GSE242199_2_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145639_1_v_6_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151090_2_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary auditory cortex (core)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.924638
Oral cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.978
HCC1187	CCLE Cell Line Gene CNV Profiles	1.0	1.41926
GSE152432_9_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Interferon regulatory factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.42
Secondary Malignant Neoplasm Of Bone	DisGeNET Gene-Disease Associations	1.0	null
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.40802
7076_RAD9A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.522188
hsa-miR-4533	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
ZNF25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56121
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09629
AP1G1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70495
Granulomatous Prostatitis	DisGeNET Gene-Disease Associations	1.0	null
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Dendritic tree	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CHP-212	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.19371
GSE216273,GSE216292_14_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02026
GSE116930,GSE116935_1_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.924638
amine biosynthetic process	GO Biological Process Annotations 2015	1.0	null
CRCGN015_MCF10A_48H:K21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05458
posteroventral (inferior) parietal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.919291
RIG-I-like receptor signaling pathway	KEGG Pathways 2026	1.0	null
apparently	GeneRIF Biological Term Annotations	1.0	null
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.945515
ATCAY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34031
GSE199255,GSE199356_3_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.2125
GSE215086_5_v_6_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GB-84-KP45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.365386
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.77894
single-organism localization	GO Biological Process Annotations 2015	1.0	null
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.2145
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.387
PMC10291819-13287_2023_3380_MOESM11_ESM.pdf-26-CXXC5_CXXC5	Rummagene Transcription Factor Associations 2026	1.0	null
Dendrite	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
vesicle	GO Cellular Component Annotations 2015	1.0	null
orbital frontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09147
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.54035
CNPPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52577
GSE164463_0_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
endoplasmic reticulum-Golgi intermediate compartment membrane	GO Cellular Component Annotations 2023	1.0	null
CRCGN008_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6177
GSE140607_5_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242199_9_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193258,GSE193259_9_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE102486,GSE102490_1_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null