association dataset threshold value standardized value H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 PMC11711664-41598_2025_85366_MOESM6_ESM.xlsx-AA-METABOLIC_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null NR2E3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13236 ZR75B Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.569535 RNASEH2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37473 GTEX-SNOS-1426-SM-32PLY GTEx Tissue Sample Gene Expression Profiles 1.0 0.931891 BRD-K58469385 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02032 GTEX-X5EB-2526-SM-4E3HY GTEx Tissue Sample Gene Expression Profiles 1.0 0.907941 BRD-K97842654 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52439 GSE140997_4_v_1_nsun6_human RummaGEO Gene Perturbation Signatures -1.0 null GSE227592_13_v_1_adar_human RummaGEO Gene Perturbation Signatures -1.0 null variation GeneRIF Biological Term Annotations 1.0 null GSE184892_6_v_5_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-T5JW-0003-SM-3NMAD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3465 CRCGN015_HEPG2_48H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.04683 TLK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00353586 BRD-K08881846 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6276 ZNF300 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86258 BRD-K35945596 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27378 TBX5-21415370-HL-1-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPATA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99387 BRD-K90697691 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21588 r6 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36659 H3K9ac_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null DVL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00505968 ectoderm TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.109319 BRD-K22316029 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71447 hsa-miR-3622b-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Skin Cutaneous Melanoma_SKCM_TCGA-GF-A769-01A-32R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXA2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.4273 HCC1599 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -2.04321 H3K27me3_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE193258,GSE193259_2_v_4_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null s-methylmethionine cycle GO Biological Process Annotations 2015 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8505-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COLO741 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.23163 HSBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85116 pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ZNF558 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23438 suprachiasmatic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02528 HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Leukemialymphoblastic(MOLT-4) BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.55076 CHDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71583 Urinary tract TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 FBXW5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.152 Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5587-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Xylem parenchyma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.661 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8518-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HGS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71978 GSE180377_2_v_1_lipa_mouse RummaGEO Gene Perturbation Signatures -1.0 null ISHIKAWAHERAKLIO02ER DepMap CRISPR Gene Dependency 1.0 3.93917 Methionine adenosyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.097 OUMS23 CCLE Cell Line Gene Expression Profiles -1.0 -1.76965 6863_PSMC6_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 3.16727 TRIM29 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00892186 hsa-miR-432 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 cingulum bundle, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.24342 mediodorsal nucleus of thalamus_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.4434 GSE157594_5_v_7_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE223241_2_v_0_cdkn2a_human RummaGEO Gene Perturbation Signatures 1.0 null PMC12036091-jcav16p2321s1.pdf-10-E2F7_E2F7 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-4661-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 EPX LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00508216 SW1271 CCLE Cell Line Gene CNV Profiles 1.0 1.49628 hsa-miR-4707-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 PPP1R13B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36815 H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null SOX7_OE_GDS3300_123_human_HESC (CA1 and CA2) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K20620780 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18683 EM2 DepMap CRISPR Gene Dependency 1.0 2.10665 ADCK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00496479 TP53INP2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00636082 valproic acid_homo sapiens_gpl6883_gse26940 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-Y8E5-0006-SM-47JWQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17277 GTEX-R53T-0005-SM-3GADK GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 GSE128844_0_v_2_chloroquine_human RummaGEO Drug Perturbation Signatures -1.0 null HSPA12B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69252 GTEX-R55F-0005-SM-2TF4W GTEx Tissue Sample Gene Expression Profiles -1.0 -0.916794 GTEX-XUZC-0005-SM-4BOQ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31497 GSE77108_8_v_7_saha_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-U8T8-0005-SM-3DB8F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15449 extracellular region part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 BRD-K92655427 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.92822 GTEX-S3XE-0626-SM-4AD6B GTEx Tissue Sample Gene Expression Profiles -1.0 -0.912513 bone marrow HPA Tissue Gene Expression Profiles -1.0 -2.06114 BRD-K57080016_-666_NCIH596_6.0_h_80.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hsa-miR-1273f TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 H3K27ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LMBR1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00701088 mRNA_RXRA_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BRD-K16305571 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13498 BRD-A80574334_13521_PHH_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Simple lobule, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.05899 Stoma TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.976 HCC630 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02339 Prostate adenocarcinoma_PRAD_TCGA-EJ-7785-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CSNK2A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46184 CALU-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.63472 GTEX-WFG8-0006-SM-3GIKS GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 GTEX-XV7Q-2326-SM-4BRVZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.943854 H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XBED-0003-SM-47JWP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34392 SP140L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93414 GSE107505_1_v_2_nanog_mouse RummaGEO Gene Perturbation Signatures 1.0 null r9 part of the vestibular column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05305 susceptibility GeneRIF Biological Term Annotations 1.0 null BRD-K30372674 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27633 hymecromone-5684 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null urinary system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 OE19 CCLE Cell Line Gene CNV Profiles -1.0 -2.68466 periventricular stratum of r9Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.19094 GTEX-XXEK-1126-SM-4BRUX GTEx Tissue Sample Gene Expression Profiles 1.0 1.64794 NCI-H847 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00323 III Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.890241 H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04785 sulfabenzamide-4979 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ARHGAP25 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00516408 BRD-A21877498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.68323 tetryzoline-6069 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE129389_0_v_5_tropifexor_mouse RummaGEO Drug Perturbation Signatures 1.0 null BRD-K13390322_AT-7519_HCC515_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null COR-L88 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35084 BRD-K18109695 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32536 Carbohydrate metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.013 H3K4me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PK-45H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.901478 H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55G-0006-SM-2TC6O GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 r11 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.97118 H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K44779507 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.75812 BRD-K37527826 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64566 GTEX-XUYS-0005-SM-47JZ2 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 Perturb_8068_KD_NONO_SRP281189 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 Pertussis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.036 Cysteine and methionine metabolism KEGG Pathways 2026 1.0 null GTEX-P78B-0005-SM-2I5GM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13598 BRD-A60245366_-666_PHH_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A25883214 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.15262 NHLH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.2327 amygdaloid complex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.901246 H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN014_HEPG2_3H:P01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.06514 GTEX-XV7Q-1226-SM-4BRVT GTEx Tissue Sample Gene Expression Profiles 1.0 1.46257 GTEX-XQ3S-0001-SM-4B64K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7018 HEC116 DepMap CRISPR Gene Dependency 1.0 2.6523 GTEX-S33H-0326-SM-4AD6N GTEx Tissue Sample Gene Expression Profiles 1.0 1.03498 BRD-K11003742 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62496 GSE242333_0_v_2_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-X62O-0005-SM-46MV1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08532 FGB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00750447 mantle zone of CA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06626 hsa-miR-4451 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 LB1047-RCC GDSC Cell Line Gene Expression Profiles 1.0 1.92708 BRD-A77216878_manumycin A_EFO27_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null aspartate family amino acid metabolic process GO Biological Process Annotations 2015 1.0 null Lung adenocarcinoma_LUAD_TCGA-73-4676-01A-01R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BICR 10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0543 GSE226249_0_v_3_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null MET_knockout_251_GDS3148 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.8783 GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38521 GPR146 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00530855 r9 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32044 NCIH1993 DepMap CRISPR Gene Dependency 1.0 3.45935 NCIH1563 CCLE Cell Line Gene Expression Profiles -1.0 -1.62084 UQCC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54005 PMC4496795-srep12063-s2.xls-STAT1_subnetwork-Gene_symbol_STAT1 Rummagene Transcription Factor Associations 2026 1.0 null GSE193258,GSE193259_9_v_15_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null AR-20517297-VCAP-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Bundle sheath cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.531 hsa-miR-4719 TargetScan Predicted Conserved microRNA Targets 1.0 0.766596 myeloid progenitor cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.06781 ARF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72964 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81S-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K72351789 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04044 GTEX-S4P3-1526-SM-3K2AV GTEx Tissue Sample Gene Expression Profiles 1.0 0.942539 vesicle GO Cellular Component Annotations 2015 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_1_CTCF Rummagene Transcription Factor Associations 2026 1.0 null BARX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39229 BRD-K47854067 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.17641 hsa-miR-3922-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 AIMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14429 Aortic Aneurysm, Abdominal HuGE Navigator Gene-Phenotype Associations 1.0 null SW 620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.2376 NCIH209 CCLE Cell Line Gene CNV Profiles -1.0 -2.23848 Basal node TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.511 Photosystem I reaction center COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.658 vacuole LOCATE Curated Protein Localization Annotations 1.0 null VIIB, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.85034 Metabolism Reactome Pathways 2024 1.0 null HSPA1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00576815 Glutamate synthase complex (NADPH) COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.913 BRD-K47474571 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52268 UROD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66679 GTEX-XLM4-0004-SM-4AT5I GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 Glume TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.819 ventrolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.912188 HOP62 BioGPS Cell Line Gene Expression Profiles 1.0 1.15521 SLC9A4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00435598 extracellular vesicular exosome GO Cellular Component Annotations 2015 1.0 null Mouth Abnormalities HuGE Navigator Gene-Phenotype Associations 1.0 null UBQLN4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00722378 BRD-K98161738 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35436 NCI-H2810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.928783 WWC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78146 BRD-K96997646 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14085 PMC10290283-biol-2022-0622-sm3.pdf-258-ZNF497_ZNF497 Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3357-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7250-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NKX2-5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00805714 GSE193258,GSE193259_5_v_3_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-Q734-0326-SM-48U15 GTEx Tissue Sample Gene Expression Profiles 1.0 1.94404 GSE138818_2_v_0_nanog_mouse RummaGEO Gene Perturbation Signatures 1.0 null OLIG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23616 r6 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0799 BRD-K02708799_GSK-1059615_HA1E_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE131887_5_v_3_doxycycline_mouse RummaGEO Drug Perturbation Signatures 1.0 null NR1I2-20693526-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE144838_7_v_8_egfr_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-U3ZM-0626-SM-4DXTV GTEx Tissue Sample Gene Expression Profiles 1.0 1.40979 periventricular stratum of PPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01507 GTEX-T5JW-1726-SM-3GADN GTEx Tissue Sample Gene Expression Profiles 1.0 1.0287 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 PMC5817105-thnov08p0972s2.xls-SIX3-GeneName_SIX3 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K96491043 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53727 H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE76771_2_v_3_atf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null Sarcoma_SARC_TCGA-X6-A8C5-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.0569 HDAC2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LARP4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69795 HDAC11 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00554345 BRD-K08219814 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.10806 CHD2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5985-11A-01R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-TMMY-1226-SM-4DXT6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.18219 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19G-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U3ZN-0126-SM-4DXUM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.883483 WAOSEL DepMap CRISPR Gene Dependency 1.0 5.47375 PMC11839389-PUL2-15-e70058-s003.xlsx-FLF_TBX4_mergeRNAseqChIPseq-symbol_TBX4 Rummagene Transcription Factor Associations 2026 1.0 null primary auditory cortex (core)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.865404 GSE246911,GSE246913_4_v_1_arid1a_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung-bronchial smooth muscle cell Tabula Sapiens Gene-Cell Associations 1.0 -0.10795 MAFK_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-W5WG-1526-SM-4LMIG GTEx Tissue Sample Gene Expression Profiles 1.0 1.01116 plastid-encoded plastid RNA polymerase complex A COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.957 BRD-K48999921 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52227 VHL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70521 BRD-K97351331 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57566 GSE148692,GSE148695_1_v_0_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE237053_1_v_0_comt_human RummaGEO Gene Perturbation Signatures 1.0 null furan CTD Gene-Chemical Interactions 1.0 null HOXC10 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.3349 RHOQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70372 intermediate stratum of r10Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01144 JHH5 CCLE Cell Line Gene Expression Profiles 1.0 1.36655 GPR120_KO_GDS4830_414_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054902 H3K27me3_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Abducens nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11919 glycerol-3-phosphate dehydrogenase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.814 GTEX-PW2O-0126-SM-48TC8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.903093 Microsporangium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.768 INSM1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.5417 H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A0VK-01A-21R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-TKQ2-1726-SM-4DXUP GTEx Tissue Sample Gene Expression Profiles 1.0 1.82223 GTEX-O5YV-0006-SM-2I5GX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12452 Prostate adenocarcinoma_PRAD_TCGA-EJ-7783-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K23704908 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61238 GSE226249_5_v_1_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-UPIC-0002-SM-3NMDC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15705 ERLIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42523 BRD-K68435627 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67724 hsa-miR-4417 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 Edema HuGE Navigator Gene-Phenotype Associations 1.0 null HPS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13422 Lung squamous cell carcinoma_LUSC_TCGA-37-4132-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYOG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.3411 SRY JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.6071 Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.153 Accessory facial motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12902 ES-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02339 H3K36me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.22228 GTEX-T5JC-2326-SM-32PMR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.837971 BRD-K05462252 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22691 facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.70933 GSE151412_2_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE102870_3_v_0_nr1h4_human RummaGEO Gene Perturbation Signatures -1.0 null cardiovascular GAD High Level Gene-Disease Associations 1.0 0.303208 BRD-K87909389_alvocidib_BT20_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.858147 mRNA_SFPI1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null sitosterol-4073 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K53665750 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.13609 CRCGN008_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.2943 inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.38641 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GR-06A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null COV362 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.465 heterocycle metabolic process GO Biological Process Annotations 2015 1.0 null non-small cell lung cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.06936 H3K27me3_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-7955-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BT-474 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16125 BMI-1_DEPLETION_GDS2445_115_human_embryonic fibroblasts GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5709-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K67141726 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32119 GTEX-RVPU-0005-SM-2TF6L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04474 ZKSCAN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54049 midbrain raphe nuclei Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.901627 carteolol-4096 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hMPV_12Hour_18234263_GSE8961 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.54007 AP-2rep MotifMap Predicted Transcription Factor Targets 1.0 null H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 15902281-TableS1e GeneSigDB Published Gene Signatures 1.0 null GTEX-SIU7-0006-SM-2XCE6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.992612 GTEX-P78B-1126-SM-3P615 GTEx Tissue Sample Gene Expression Profiles 1.0 0.992094 10922_NON-TARGETING_NON-TARGETING Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.77003 LYRM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26797 rs673752 GeneRIF Biological Term Annotations 1.0 null SPOCK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00644206 BRD-K42716291 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16054 HCC1319 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.81803 GTEX-SNOS-0003-SM-3NMAO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58774 PMC6713698-109_2019_1809_MOESM2_ESM.xlsx-AR-PCOS-Gene_List_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K27me3_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K96799727_-666_U937_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null VIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.82109 metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-XGQ4-0004-SM-4AT5S GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 BBS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17851 GTEX-Q2AH-0226-SM-48U1I GTEx Tissue Sample Gene Expression Profiles -1.0 -0.944414 OCEL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56519 ZBTB7C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97628 Metabolism of amino acids and derivatives Reactome Pathways 2024 1.0 null leukocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057729 primary motor cortex (area M1, area 4)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.00374 PANC 05.04 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.71763 BRD-K00359952 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.20189 urinary system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CRCGN015_MCF10A_48H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.1275 nucleus coeruleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.15385 amino acid salvage GO Biological Process Annotations 2023 1.0 null HDAC1 ENCODE Transcription Factor Targets 1.0 null HRH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13004 BRD-K73695595 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17705 DOCK5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00573536 genegene GeneRIF Biological Term Annotations 1.0 null GTEX-WOFM-0005-SM-3MJF3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13951 GTEx Muscle 20-29 vs 70-79 GTEx Tissue-Specific Aging Signatures -1.0 -9.71298 Rumen epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.885 organic cyclic compound metabolic process GO Biological Process Annotations 2015 1.0 null 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.634 ALPK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0060387 superficial stratum of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.47354 GTEX-RWSA-0005-SM-2XCAO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.835329 BRD-K63587749 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.04554 dorsolateral prefrontal cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.940008 liver_d HPA Tissue Sample Gene Expression Profiles 1.0 1.37435 WRAP73 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49276 PMC11461876-42003_2024_6975_MOESM3_ESM.xlsx-Supplementary_Data_1-Supplementary_Data_1_Differentially_Expressed_Genes_HSE_THP1_Vs_THP1_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K54100199 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30375 GSE226249_0_v_1_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-A66861218_-666_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Cleft Palate CTD Gene-Disease Associations 1.0 2.88009 GTEX-WH7G-0002-SM-4LVN9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04666 Adipose - Visceral (Omentum) GTEx Tissue Gene Expression Profiles 2023 1.0 5.5821 PPARGC1A_KO_GDS2391_299_mouse_brain striatum GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null membrane-bounded vesicle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE194396,GSE194429_2_v_0_atrx_human RummaGEO Gene Perturbation Signatures -1.0 null KG1C CCLE Cell Line Gene Expression Profiles -1.0 -2.30648 GTEX-U3ZG-0006-SM-47JWX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07366 GSE216538_5_v_6_mrs2_mouse RummaGEO Gene Perturbation Signatures -1.0 null One carbon pool by folate KEGG Pathways 2026 1.0 null Protoxylem TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.677 HUH1 CCLE Cell Line Gene Expression Profiles 1.0 1.54499 GSE158458_2_v_3_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney Diseases CTD Gene-Disease Associations 1.0 1.33731 GTEX-S33H-0005-SM-2XCAL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.861935 hsa-miR-4680-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.568687 GTEX-W5WG-0006-SM-3GIJT GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 GSE216538_0_v_4_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null cerebellar vermis Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2725 NIF3L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90755 r7 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20697 COV318 CCLE Cell Line Gene CNV Profiles -1.0 -1.65526 KMRC2 CCLE Cell Line Gene Expression Profiles 1.0 1.68434 BRD-A80705936 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.22842 pineal_night BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.05255 diphemanil metilsulfate-4416 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Field CA1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13827 ZNF221 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38987 GRK3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00599663 SOX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.2143 BRD-K26767874 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19565 BRD-K02614439 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30908 Cleft lip DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.106 RBM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6727 dorsal motor nucleus of the vagus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2413 EKVX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.853927 GTEX-WYJK-1426-SM-3NM8V GTEx Tissue Sample Gene Expression Profiles 1.0 0.953899 ZBTB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49129 GTEX-X4XX-0005-SM-3NMCS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4511 BRD-K44856541 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14172 mRNA_ATF3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EGFR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00350753 central nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053863 GSE226316_3_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GRM1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00764693 Necrosis CTD Gene-Disease Associations 1.0 1.91217 GSKIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36269 BRD-K23292451 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30373 APOC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24906 LSM7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00619841 HCC-70 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.733 polymorphic layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.42596 Eye-retinal blood vessel endothelial cell Tabula Sapiens Gene-Cell Associations 1.0 -0.107593 RTCA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01286 Primary cell wall COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.572 Bacteriocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.629 MLNR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00509924 rnf2_20123906_mouse_embryonic_stem_cell_lof_mouse_gpl1261_gse19076 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.037127 FOXL1 JASPAR Predicted Transcription Factor Targets 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7058-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KCNMB4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00535744 CRCGN017_MCF10A.TP53.M_24H:K24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.37689 cellular_component GO Cellular Component Annotations 2015 1.0 null DPPA4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00519253 CADM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59539 MAPKAPK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61766 Prostate adenocarcinoma_PRAD_TCGA-EJ-7786-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-R55D-0006-SM-3GIJS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.959532 pancuronium bromide-4393 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GATA4_KO_GDS3486_483_mouse_jejunum GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5696-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null perilemniscal isthmic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20121 PC-3 GDSC Cell Line Gene Expression Profiles -1.0 -2.28274 intracellular organelle LOCATE Curated Protein Localization Annotations 1.0 null GSE144443_5_v_7_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null TCCSUP CCLE Cell Line Gene Expression Profiles -1.0 -2.35925 Lung adenocarcinoma_LUAD_TCGA-78-7633-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-1254 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 GSE135350_2_v_7_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null SZ in subgenual cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11659 GTEX-Q2AG-2826-SM-2HMJQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.843268 pontobulbar body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.23707 BRD-K01973494 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00837 RWDD2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45785 intracellular part GO Cellular Component Annotations 2015 1.0 null Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.235 496100375_FWM_dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.19969 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7923-01A-12R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null amino acid salvage GO Biological Process Annotations 2015 1.0 null baclofen_mus musculus_gpl1261_gse17266 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K70057550 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.5442 GTEX-XUYS-0002-SM-47JXL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19162 BRD-K50443235 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6766 GTEX-WZTO-0006-SM-3NM9T GTEx Tissue Sample Gene Expression Profiles -1.0 -0.835045 Field CA1, stratum oriens Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11698 Uterine Carcinosarcoma_UCS_TCGA-N5-A4RT-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K14392329 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.98654 BRD-K63008302 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29968 REST ENCODE Transcription Factor Targets 1.0 null MHH-NB-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.866394 Lung adenocarcinoma_LUAD_TCGA-35-5375-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H4C5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.57907 revealed GeneRIF Biological Term Annotations 1.0 null GTEX-VUSH-0004-SM-3P61T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11255 6846_PSMA6_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 3.35566 PMC5291205-srep41905-s3.xlsx-LPS_datasets_gmx-Unnamed_3_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null SOX14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.0725 Crus 1, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03554 troglitazone-6191 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC9710014-12876_2022_2535_MOESM2_ESM.pdf-44-CSRNP3_CSRNP3 Rummagene Transcription Factor Associations 2026 1.0 null Field CA3, stratum lacunosum-moleculare Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25296 Dorsal column nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.48837 Liver hepatocellular carcinoma_LIHC_TCGA-NI-A8LF-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4643 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 Culmen Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07039 NCIH2347 CCLE Cell Line Gene Expression Profiles 1.0 1.35302 BRD-K65934178 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21881 GTEX-X3Y1-2426-SM-3P5Z7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.25548 GSE135350_3_v_6_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null Posterior parietal association areas, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08388 GTEX-OXRK-0006-SM-2HML1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.931272 H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TK-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01651 EFNA1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00551536 BRD-A91461229 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.14926 BRD-K14241686 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36217 PROCA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85179 CXADR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77458 EPHB3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.004446 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I8-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null microcellular tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5503 SHMT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0074944 GSE224311_3_v_4_chaetocin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE207302,GSE207303_0_v_2_tp53bp2_human RummaGEO Gene Perturbation Signatures 1.0 null CIB4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00804465 DMBT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00660883 mRNA_OTX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null mRNA_MYOD1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null U87MG Achilles Cell Line Gene Essentiality Profiles 1.0 1.00416 ChIP_EZH2_18974828 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTEX-OHPM-0006-SM-2HMKU GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 GSE128844_0_v_1_chloroquine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-X4XY-1626-SM-46MVN GTEx Tissue Sample Gene Expression Profiles 1.0 1.18917 superior periolivary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33017 L-methionine salvage GO Biological Process Annotations 2023 1.0 null Intraciliary transport particle A COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.65 Crus 1, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21088 Hyperhomocysteinemia DisGeNET Gene-Disease Associations 1.0 null spinal (inferior) vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.55305 RPMI 8226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.63308 DDIT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75242 LCLC-103H GDSC Cell Line Gene Expression Profiles -1.0 -1.55625 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3358-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K86946907 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19015 Urinary system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 TMEM265 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58542 FOXO1::ELF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.0605 MIDN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76037 BARX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.4893 Spermine HMDB Metabolites of Enzymes 1.0 null BRD-K14383477 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02705 MGAT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36072 GTEX-SNMC-1326-SM-2XCFK GTEx Tissue Sample Gene Expression Profiles 1.0 0.847716 H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7406-11A-01R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K52552873 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4159 BRD-K22248406 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.05049 SUP-T1 COSMIC Cell Line Gene Mutation Profiles 1.0 null KIF21B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00426019 intermediate stratum of r8BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35579 alimentary canal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052191 SKRC31 CCLE Cell Line Gene CNV Profiles 1.0 1.47725 GTEX-WH7G-0526-SM-3NMBI GTEx Tissue Sample Gene Expression Profiles 1.0 0.950574 Perturb_6035_KD_MBD3_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 17.8633 PTPN18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29775 BRD-K12343256_trametinib_HCC515_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MG-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K82919339 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.06878 Liver Diseases CTD Gene-Disease Associations 1.0 1.16733 GTEx Skin 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures 1.0 7.27688 NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.909557 Liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.211 carboxylic acid metabolic process GO Biological Process Annotations 2015 1.0 null H3K27ac_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K88573743_A443654_SKBR3_3_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE112365_0_v_1_sirt1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-TML8-0001-SM-3NMAF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3207 Lung adenocarcinoma_LUAD_TCGA-44-2659-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE193402_0_v_2_imatinib_human RummaGEO Drug Perturbation Signatures -1.0 null CDX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7861 Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A13J-11A-13R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K56437119 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05398 Liver cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.05 PSKH2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00580554 BRD-K54112192 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24655 DENND11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91305 496100531_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.94949 BRD-K34234678 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.1436 GTEX-S32W-1926-SM-4AD63 GTEx Tissue Sample Gene Expression Profiles 1.0 1.66746 N1-Acetylspermine HMDB Metabolites of Enzymes 1.0 null PMC8257499__F5 PFOCR Pathway Figure Associations 2024 1.0 null Gracile nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.24495 GSE62843,GSE64371_4_v_0_furan_mouse RummaGEO Drug Perturbation Signatures 1.0 null UMRC6 CCLE Cell Line Gene Expression Profiles 1.0 1.88482 GSE252958_1_v_0_znf469_human RummaGEO Gene Perturbation Signatures 1.0 null GSE210655_3_v_4_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null BHLHE40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28463 BRD-K35469110 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17227 H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WH7G-1026-SM-4LVML GTEx Tissue Sample Gene Expression Profiles 1.0 1.13049 BRD-K06117861 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.98254 GTEX-XBED-1126-SM-48TCF GTEx Tissue Sample Gene Expression Profiles 1.0 1.30708 H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null cofactor metabolic process GO Biological Process Annotations 2015 1.0 null CLDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08426 Eye-ciliary body Tabula Sapiens Gene-Cell Associations 1.0 -0.106521 occipital pole, left, lateral aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.05858 BRD-K01951210 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68905 Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5581-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAFK_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K57464717 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63067 M059K CCLE Cell Line Gene CNV Profiles 1.0 1.61332 BRD-K12132610 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03038 DEPDC5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00474928 KCND3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00556647 GSE217363_4_v_1_nlrp3_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZSCAN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72208 H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NDUFAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65994 SHSYSY-RA BioGPS Cell Line Gene Expression Profiles -1.0 -0.872922 Perturb_14396_KO_SYK_SRP124678 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 RANBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70862 Uterus BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.45129 NCIH1666 CCLE Cell Line Gene Expression Profiles -1.0 -1.45981 BRD-K13350372 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.13418 layer III of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.962617 GSE149264,GSE149267_2_v_1_trp53_mouse RummaGEO Gene Perturbation Signatures 1.0 null SNU878 CCLE Cell Line Gene Expression Profiles 1.0 1.7145 BRD-K57169635_dacomitinib_HCC515_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-A4D0-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K12705251 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63998 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5879-11A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4710 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 TM6SF1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00560545 transition metal ion binding GO Molecular Function Annotations 2023 1.0 null NCIH1563 CCLE Cell Line Gene CNV Profiles 1.0 1.84394 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A0VM-01A-11R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RNF2 ChEA Transcription Factor Targets 1.0 null PK45H DepMap CRISPR Gene Dependency 1.0 4.79878 GTF3C6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42295 FOXO1::ELK3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.1534 eed_20123906_mouse_embryonic_stem_cell_lof_mouse_gpl1261_gse19076 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.014602 orbital frontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.17406 GTEX-PWOO-0826-SM-48TCL GTEx Tissue Sample Gene Expression Profiles 1.0 1.49872 BRD-K36096526 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.90809 Bilateral optic nerve hypoplasia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.074 paraventricular nuclei, left of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.10883 Lung adenocarcinoma_LUAD_TCGA-44-2655-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAPK3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00451039 Skin-cell of skeletal muscle Tabula Sapiens Gene-Cell Associations 1.0 -0.107593 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5988-11A-01R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_15999_KD_TP53_SRP261893 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE207787_3_v_2_pdha1_human RummaGEO Gene Perturbation Signatures 1.0 null SUCLG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.81079 nucleus of the inferior collicular brachium, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25543 icSARS CoV_48Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.37009 BRD-K09271653 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06225 6860_PSMC3_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.78614 BRD-K79148949 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37527 anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.1551 olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.986517 BRD-K84707727 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.24205 BRD-K30697463_desoximetasone_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SOX13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.9185 GTEX-RN64-1826-SM-48FDV GTEx Tissue Sample Gene Expression Profiles 1.0 3.05442 UCK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00685512 EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6939-11A-01R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K75164441 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52556 TBK1_knockdown_53_GSE17643 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.92254 GTEX-VUSG-1426-SM-3GIJN GTEx Tissue Sample Gene Expression Profiles 1.0 1.17008 PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Ensembl_ID_FOXM1 Rummagene Transcription Factor Associations 2026 1.0 null neuro2a BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.956438 496100564_TCx_no dementia_no TBI_82_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.05295 RAB3IP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00664446 BRD-K55105453 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.26701 layer VI of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.965622 H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Nucleus of the lateral olfactory tract, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17657 GSE135439_0_v_1_pax5_human RummaGEO Gene Perturbation Signatures 1.0 null JHOC5 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.21265 GSE194396,GSE194429_1_v_0_atrx_human RummaGEO Gene Perturbation Signatures -1.0 null tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.431843 ADH1B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00673894 GTEX-S7SE-0005-SM-2XCEA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64313 GAA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00367508 H3K27me3_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K09900382 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18704 YY1_KO_GSE39009_49_mouse_skeletal muscle (6 mo) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Infertility, Female HuGE Navigator Gene-Phenotype Associations 1.0 null CAOV3 CCLE Cell Line Gene Expression Profiles 1.0 1.49745 GTEX-XUJ4-1126-SM-4BOPC GTEx Tissue Sample Gene Expression Profiles 1.0 1.33724 FLI1-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null SG in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 3.34439 GSE256181_2_v_0_etv2_human RummaGEO Gene Perturbation Signatures 1.0 null cetirizine-2468 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-UPK5-1626-SM-4JBHI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.898231 GTEX-PWN1-0726-SM-48TDR GTEx Tissue Sample Gene Expression Profiles 1.0 1.0378 plastid-encoded plastid RNA polymerase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.92 Prostate adenocarcinoma_PRAD_TCGA-HC-7745-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JPT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52311 CRCGN015_HEPG2_48H:P04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.88183 TRIM33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35081 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EH-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WFJO-0726-SM-4LVM8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.25353 GTEX-RUSQ-0926-SM-47JWU GTEx Tissue Sample Gene Expression Profiles 1.0 0.942564 NCIH2452 Achilles Cell Line Gene Essentiality Profiles 1.0 1.39874 medial habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.76928 GTEX-OIZH-0005-SM-2HMJN GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 GTEX-OIZG-0005-SM-2HMJC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00353 Syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.419 GTEX-Q2AG-1126-SM-48U1P GTEx Tissue Sample Gene Expression Profiles 1.0 1.92703 CDC42BPB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.1989 SW837 CCLE Cell Line Gene CNV Profiles 1.0 1.88765 BRD-K70643771 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39266 Pollen TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.092 MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K79090631_CGP-60474_HCC515_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K71103788_duloxetine_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null IRF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 58.7567 SHOX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.2115 PROSER3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57375 NCIH292 DepMap CRISPR Gene Dependency 1.0 3.30619 GATA5_KO_GSE47425_386_mouse_lung GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YL-A8HJ-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null droperidol-4629 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC7339546-12915_2020_793_MOESM2_ESM.xlsx-Table_S12-Table_S12_common_twin_genes_in_one_HMR_core_region_between_cattle_and_human_NR4A1 Rummagene Transcription Factor Associations 2026 1.0 null HLE CCLE Cell Line Gene CNV Profiles 1.0 1.3611 ADAM19 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0055701 hsa-miR-548ai TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05925 BRD-K19220233_JNK-9L_A375_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GPR82 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00541901 Choline deficiency disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.412 H3K27ac_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5890-11A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intercalated nucleus of medulla Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.50479 H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KL-8324-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16125 H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-TMMY-1526-SM-4DXST GTEx Tissue Sample Gene Expression Profiles 1.0 1.01778 Cleft Lip DisGeNET Gene-Disease Associations 1.0 null GTEX-U4B1-0926-SM-4DXUV GTEx Tissue Sample Gene Expression Profiles 1.0 1.6178 liver TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.528323 FOSL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4719 alpha-amino acid metabolic process GO Biological Process Annotations 2015 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8435-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Anterior olfactory nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.15435 HCC1263 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.29252 GSE172016_2_v_0_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null SHSY5Y DepMap CRISPR Gene Dependency 1.0 3.88801 BRD-K44950949 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.68785 GTEX-S4P3-0006-SM-3K2AW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18646 Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5585-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Obesity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.114 CRCGN017_MCF10A.WT.HP_24H:K24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8487 TK10 GDSC Cell Line Gene Expression Profiles 1.0 1.73896 preoptic region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.97431 HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.853927 BRD-K69238239 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.56688 habenula (old epithalamus) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14968 striatum_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.74694 H3K9ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SNMC-0426-SM-4DM5Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.18949 GTEX-QCQG-0726-SM-48U1Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.939103 BRD-K44427106 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03449 female reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.046508 hsa-miR-34b TargetScan Predicted Conserved microRNA Targets 1.0 0.670641 ECC10 CCLE Cell Line Gene CNV Profiles -1.0 -1.61983 Norspermidine HMDB Metabolites of Enzymes 1.0 null metabolism GeneRIF Biological Term Annotations 1.0 null ASIC3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0051912 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70H-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ONECUT3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 60.7714 superficial stratum of PO1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01068 GABRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88644 H2AC12 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00518853 GSE217363_0_v_1_nlrp3_mouse RummaGEO Gene Perturbation Signatures 1.0 null dorsalstriatum BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.963689 H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 6875_PSMD7_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.26714 FSTL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08894 H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NPJ8-0007-SM-2D7VX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23506 GSE241036_4_v_2_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null MDAMB436 CCLE Cell Line Gene CNV Profiles 1.0 1.69747 GTEX-TKQ2-0004-SM-3NMAC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17487 ESX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64955 KP4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.28285 SEPTIN7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.2557 CLPX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39461 GTEX-XAJ8-0006-SM-46MVM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37263 Hepatobiliary disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.198 BRD-A59995060 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40242 Leaf sheath TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.679 vitamin c_mus musculus_gpl6246_gse19377 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K35209334 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.1002 S-adenosylmethionine metabolic process GO Biological Process Annotations 2025 1.0 null FOXL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.1739 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3387-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1HW-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SLC22A6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00558185 leukemia cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.067465 cellular modified amino acid metabolic process GO Biological Process Annotations 2015 1.0 null MTX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57696 zinc ion binding GO Molecular Function Annotations 2025 1.0 null H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-4397-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K16149312 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31229 adipose tissue HPA Tissue Gene Expression Profiles 1.0 0.862187 VGF LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00420859 NDRG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03107 RBM6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00333215 GSE193258,GSE193259_9_v_0_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K92879007 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.80111 hsa-miR-4435 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 JJ012 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0543 BRD-K43389698_BMS-387032_A549_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null COLO-800 GDSC Cell Line Gene Expression Profiles -1.0 -1.54381 ADRA2B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00397801 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VUSG-0426-SM-3GIKD GTEx Tissue Sample Gene Expression Profiles 1.0 0.888721 GTEX-VUSG-0126-SM-4KL1X GTEx Tissue Sample Gene Expression Profiles 1.0 1.81222 BRD-K40016301 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.69997 H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K35122752 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12875 VIIAf Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.832252 BRD-K59523233 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.95925 GSE224311_3_v_1_chaetocin_human RummaGEO Drug Perturbation Signatures -1.0 null LIPC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00618692 GTEX-OHPL-0006-SM-3MJHB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14412 GSE226249_2_v_7_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null CHTF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76378 r10 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.69726 Allograft Rejection(Homo sapiens) WikiPathways Pathways 2014 1.0 null CHRNG LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00626275 PFKFB3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00768046 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4338-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QEG4-0006-SM-2I5FY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24877 GSE148263_6_v_0_trim3_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K64215924 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22045 BT483 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.990445 erythrocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.179705 Liver TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 BCL11B_KO_GSE9330_4_mouse_brain (striatum) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K66311249 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42945 HIPK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.31477 GTEX-XUW1-1026-SM-4BONY GTEx Tissue Sample Gene Expression Profiles 1.0 1.06164 PFEIFFER Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.3785 GTEX-XGQ4-0126-SM-4AT4H GTEx Tissue Sample Gene Expression Profiles -1.0 -0.831482 GP6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00886897 Wt1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 62.0904 SK-MES-1 GDSC Cell Line Gene Expression Profiles 1.0 1.72334 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null ITPKA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00533778 GSE256181_2_v_3_etv2_human RummaGEO Gene Perturbation Signatures 1.0 null M-1 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.1412 hsa-miR-4771 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 BRD-K65259629 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16871 DMS454 CCLE Cell Line Gene Expression Profiles 1.0 1.56541 HNF4A JASPAR Predicted Transcription Factor Targets 1.0 null SEMA3G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54402 BRD-K30198800 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77081 RNF2 ENCODE Transcription Factor Targets 1.0 null BRD-K19220233_JNK-9L_A549_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SETBP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00664695 ion binding GO Molecular Function Annotations 2015 1.0 null BRD-K37544873 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25393 POLRMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84835 TCF12_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ribonucleoside metabolic process GO Biological Process Annotations 2015 1.0 null LHX1_NULL MUTATION - Ablation_GDS1748_749_mouse_Embryonic kidneys (from day E18.5) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null DMD LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00639268 BRD-K21680192_mitoxantrone_BT20_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ARTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01491 GTEX-P4PP-0726-SM-3NM9S GTEx Tissue Sample Gene Expression Profiles 1.0 1.11985 BRD-K70819166 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33483 GTEX-RM2N-1926-SM-48FCU GTEx Tissue Sample Gene Expression Profiles 1.0 2.15339 BRD-K37596331 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15654 GSE242367_1_v_0_dpp9_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WEY5-0006-SM-3GIKG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.918697 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5878-11A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FBXO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20345 NCI-H1792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.33371 GTEX-T5JC-1526-SM-4DM68 GTEx Tissue Sample Gene Expression Profiles 1.0 1.90347 GSE184892_6_v_3_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null NRBF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20808 Anterior cingulate area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.41347 OCUG1 DepMap CRISPR Gene Dependency 1.0 6.09789 kidney TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.217139 Prostate adenocarcinoma_PRAD_TCGA-EJ-7314-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VCP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00780845 BRD-K37510443 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.89565 embryoday7.5 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.90732 GTEX-R55E-0006-SM-2TC5G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.886243 6868_PSMD14_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.52755 BRD-K31195910 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34061 Heart disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.027 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null chr5_79071641_C_G_b38 GTEx eQTL 2025 1.0 4.70392 H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.893919 GSE182179_0_v_1_kdsr_human RummaGEO Gene Perturbation Signatures 1.0 null VSIG2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00425097 HEC6 DepMap CRISPR Gene Dependency 1.0 3.72884 EP300_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of PO2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01436 H3K9me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-A71459254_-666_PHH_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null S1PR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83103 EPHB2_drugactivation_228_GSE26523 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.69371 TOR1AIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25874 H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TMMY-0626-SM-33HBD GTEx Tissue Sample Gene Expression Profiles 1.0 0.89426 KYSE150 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.12598 TMEM229A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75062 GTEX-XYKS-0002-SM-4BRWN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61895 HFE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00487 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A57E-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF594 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3464 GTEX-S4Z8-0006-SM-3K2AQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11984 GTEX-S95S-0002-SM-3NM8K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30864 inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.1702 FOXK2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.7484 Heart valve TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.991 BRD-K07384081 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62458 SG in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.17048 A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09067 ChIP_MTF2_20144788 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTEX-SE5C-1026-SM-4BRUG GTEx Tissue Sample Gene Expression Profiles 1.0 1.21764 Acute Myeloid Leukemia_LAML_TCGA-AB-2897-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A52024592 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.39625 UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K31233830 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52806 PMC6962646-mmc2.xlsx-StemCell_Genesets_2018-NANOG_NANOG Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QDVJ-0826-SM-48U1S GTEx Tissue Sample Gene Expression Profiles 1.0 0.967465 kidney_d HPA Tissue Sample Gene Expression Profiles 1.0 1.75685 BRD-K52231520 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2092 GTEX-QEG5-0006-SM-2I5FZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52425 brain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053966 transition metal ion binding GO Molecular Function Annotations 2015 1.0 null nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052759 GTEX-QLQW-1226-SM-2S1Q9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.52848 Anterior olfactory nucleus, external part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.42097 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null GSE226316_11_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC7594423-12915_2020_895_MOESM13_ESM.xlsx-Table_S6D-Table_S6D_-_Differentially_Expressed_genes_shared_between_BRCA_TRIM25_amp_and_STAD_CIC_Del_CIC Rummagene Transcription Factor Associations 2026 1.0 null GTEX-U3ZH-0002-SM-3NMDD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57169 Sarcoma_SARC_TCGA-MO-A47P-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K14799424 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12206 GSE152734,GSE152735_2_v_0_pbrm1_human RummaGEO Gene Perturbation Signatures 1.0 null GATA2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00365292 GTEX-X8HC-1526-SM-46MWD GTEx Tissue Sample Gene Expression Profiles 1.0 0.996045 H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE244072_10_v_9_tfeb_mouse RummaGEO Gene Perturbation Signatures 1.0 null blood GTEx Tissue Gene Expression Profiles -1.0 -1.65199 FAM3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59431 FEN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00668223 GSE237040_6_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null PLEC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29124 Betaine HMDB Metabolites of Enzymes 1.0 null NFKB2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0152448 GDF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86365 c2c12 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.23697 GTEX-VJYA-0001-SM-3NMDJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22522 BRD-K19766710 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15673 Hak TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.782 G44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.984704 H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XOTO-0006-SM-4B64T GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 BRD-K82674931 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.60495 BRD-K09108485 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50748 DDR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00068 intermediate part of r10B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05896 6886_PSMG3_P1 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.52896 brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.212945 GSE112763,GSE112767_0_v_3_dgcr8_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC10260405-41588_2023_1409_MOESM6_ESM.xlsx-ST12-Supplementary_Table_12_Most_likely_causal_genes_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null PAOX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16438 GTEX-O5YW-0006-SM-3LK6E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46127 BRD-K42145213 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.04827 OPA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53061 GTEX-X585-0002-SM-46MVA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28576 GSE228430_2_v_3_fabp5_human RummaGEO Gene Perturbation Signatures 1.0 null IL18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21692 BRD-K83143868 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0769 S1PR5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35939 MAFK ENCODE Transcription Factor Targets 1.0 null cerebellum BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.64856 H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE146074_0_v_7_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.909557 BRD-K46239950 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.8393 CRCGN011_HEPG2_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.5353 periventricular stratum of Pal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04379 BRD-K70843862 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07779 amygdaloid complex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.36871 central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041374 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_3_CTCF Rummagene Transcription Factor Associations 2026 1.0 null GPAT3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00482946 BRD-K42126874 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.35497 arcuate nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.5169 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 laterodorsal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.41622 PMC6606599-41598_2019_45777_MOESM14_ESM.xlsx-SAVA_DE_genes_promoter_DMRs-Unnamed_22_TBXT Rummagene Transcription Factor Associations 2026 1.0 null cell part GO Cellular Component Annotations 2015 1.0 null CDX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.5118 BRD-K70518736 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08103 EFHD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62874 GTEX-PSDG-1426-SM-48TD1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.49514 6842_PSMA2_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.53623 Vitamin U CTD Gene-Chemical Interactions 1.0 null GSE112763,GSE112767_4_v_1_dgcr8_mouse RummaGEO Gene Perturbation Signatures 1.0 null SOX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.9315 GTEX-UJMC-0005-SM-3GACU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02333 H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null DGKE LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.006209 PMC4183535__F4 PFOCR Pathway Figure Associations 2024 1.0 null GTEX-QV44-1825-SM-447CF GTEx Tissue Sample Gene Expression Profiles 1.0 0.88289 membrane-bounded vesicle GO Cellular Component Annotations 2015 1.0 null Mesothelioma_MESO_TCGA-LK-A4O0-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GPR107 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25223 disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.193285 A1CF LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00436554 GTEX-SJXC-1226-SM-4DM78 GTEx Tissue Sample Gene Expression Profiles 1.0 2.3415 ROPN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00634201 CNTRL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85191 BRD-K00530465 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.87835 EZH2_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null indusium griseum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.884323 GTEX-X638-0003-SM-47JZ1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00979 BRD-K00086692 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02254 s-methyltransferase activity GO Molecular Function Annotations 2015 1.0 null MXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.5677 inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.906098 496100551_PCx_no dementia_no TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.28176 A704 CCLE Cell Line Gene Expression Profiles 1.0 1.99103 GTEX-XUW1-1326-SM-4BOO1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04907 6845_PSMA5_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 3.06667 Prestwick-857-3355 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-RU72-0006-SM-2TF65 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.853726 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AG-06A-31R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null diloxanide-3062 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K07011015 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.016 CRCGN015_MCF10A.WT.HP_24H:I10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.04196 6872_PSMD4_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.96323 alpha-amino acid biosynthetic process GO Biological Process Annotations 2015 1.0 null CHST13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6506 hematopoietic stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065484 cytoplasm LOCATE Predicted Protein Localization Annotations 1.0 null dorsolateral prefrontal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.08021 GTEX-RUSQ-0126-SM-47JWV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.88051 7163_RBM19_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.29259 GTEX-PLZ6-1726-SM-2S1O6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.851679 BRD-A02927672 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15416 Autosomal dominant cutis laxa 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.096 GSE239747_1_v_3_lrp6_mouse RummaGEO Gene Perturbation Signatures -1.0 null DACH1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00459026 Anterior cingulate area, dorsal part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31678 BRD-K56916066 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14405 PDK1_knockout_265_GSE42187 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.39391 PMC12623973-41467_2025_64981_MOESM3_ESM.xlsx-downregulated-c0_ACKR4_SCS_ceiling_LEC_TWIST1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K39813155 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82773 MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hyperhomocysteinemia GeneRIF Biological Term Annotations 1.0 null RTEL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0077561 GSE112763,GSE112767_0_v_1_dgcr8_mouse RummaGEO Gene Perturbation Signatures 1.0 null AN3 CA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15423 TOP3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22237 STAT3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00434195 binding GO Molecular Function Annotations 2015 1.0 null GTEX-QXCU-0006-SM-2TC5K GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 NFIC ENCODE Transcription Factor Targets 1.0 null GTEX-T6MN-0005-SM-32PLJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.962022 PIP5K1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00362167 BRD-K25064302 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50261 inflammatory abnormality of the skin GWASdb SNP-Phenotype Associations 1.0 0.253791 BRD-K68174511_torin-2_MDAMB231_3_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-73-4675-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.950326 BRD-K19220233_JNK-9L_HME1_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null carbohydrate derivative metabolic process GO Biological Process Annotations 2015 1.0 null NCIH2052 DepMap CRISPR Gene Dependency 1.0 2.88522 Plantlet TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.034 BRD-K25280080 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.71267 Signal recognition particle, endoplasmic reticulum targeting COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.699 FNDC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88077 r8 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35333 liver_a HPA Tissue Sample Gene Expression Profiles 1.0 1.37667 LAMA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25895 mouth TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058457 ZNF582 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.4437 r11 part of spinal trigeminal nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06342 BRD-K86998514 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.85185 LOVO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.33059 Fruit capsule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.887 TM9SF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8779 BRD-A03997826 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2902 r9 part of nucleus gracilis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17812 One carbon metabolism and related pathways(Mus musculus) WikiPathways Pathways 2014 1.0 null GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.68019 hsa-miR-3619-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 CRCGN015_HEPG2_48H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.42342 BRD-K13390322_AT-7519_A549_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE216043_10_v_6_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7330-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K49666076 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01644 GTEX-O5YT-0926-SM-48TDG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.878729 PMC7603494-41467_2020_19353_MOESM6_ESM.xlsx-Ch_TCF3_up_and_binding_Overlapp-Unnamed_1_TCF3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-RU1J-0426-SM-46MUK GTEx Tissue Sample Gene Expression Profiles 1.0 1.36861 GSE244233_1_v_0_quercetin_human RummaGEO Drug Perturbation Signatures -1.0 null L-363 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.47724 Mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.984 TASK1 DepMap CRISPR Gene Dependency 1.0 4.00421 BRD-A54490075 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19891 LY6G5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17854 BRD-K18077898 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1633 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZF-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null organic acid metabolic process GO Biological Process Annotations 2015 1.0 null NR1H2::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.08 NAMPT LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00439285 Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5587-01A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE172016_2_v_5_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WY7C-2726-SM-3NB3P GTEx Tissue Sample Gene Expression Profiles 1.0 1.11776 CRCGN011_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.7458 PMC10346484__F2 PFOCR Pathway Figure Associations 2024 1.0 null CCNYL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34759 intermediate stratum of r9BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32121 Mesothelioma_MESO_TCGA-SH-A7BC-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null rostral ventrolateral reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05087 Paraneoplastic polyneuropathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.098 VIM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20435 BRD-K73872184 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30419 GSE140997_4_v_7_nsun6_human RummaGEO Gene Perturbation Signatures -1.0 null pemt GeneRIF Biological Term Annotations 1.0 null GTEX-N7MS-1626-SM-3LK5F GTEx Tissue Sample Gene Expression Profiles 1.0 3.17422 GSE197342_2_v_0_berberine_mouse RummaGEO Drug Perturbation Signatures 1.0 null CIC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00792187 bhmt GeneRIF Biological Term Annotations 1.0 null l-methionine biosynthetic process GO Biological Process Annotations 2015 1.0 null H3K4me3_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HPGDS LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00630974 Brain Lower Grade Glioma_LGG_TCGA-DU-6402-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.411251 PMC2866657-pone.0010547.s001.xls-ERG-high-GENES_DOWNREGULATED_IN_ERGhigh_ERG Rummagene Transcription Factor Associations 2026 1.0 null BACH1 ChEA Transcription Factor Targets 1.0 null AAMP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00641894 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4713-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XAJ8-0326-SM-47JYI GTEx Tissue Sample Gene Expression Profiles 1.0 0.853552 GTEX-WFJO-0002-SM-3P61X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15275 SGPP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21202 PRC1_BMI_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null GTEX-QESD-2026-SM-447BI GTEx Tissue Sample Gene Expression Profiles 1.0 2.48643 H3K27me3_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lip GeneRIF Biological Term Annotations 1.0 null GTEX-PLZ5-0826-SM-3P5ZW GTEx Tissue Sample Gene Expression Profiles 1.0 1.1759 H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K48092898 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.81438 S-methylmethionine-homocysteine S-methyltransferase activity GO Molecular Function Annotations 2025 1.0 null Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PANK3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00501555 Lung adenocarcinoma_LUAD_TCGA-55-A4DF-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null fat_e HPA Tissue Sample Gene Expression Profiles 1.0 0.93115 Fat-smooth muscle cell Tabula Sapiens Gene-Cell Associations 1.0 -0.10795 GTEX-WHWD-0005-SM-3LK7D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11092 sisomicin-4014 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CERKL LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00851222 TMEM98 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00751462 IKZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.9174 CFPAC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.927562 intermediate stratum of r6BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36825 GTEX-WY7C-0226-SM-3NB37 GTEx Tissue Sample Gene Expression Profiles 1.0 0.983922 BRD-A86109770_Guggulsterone_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE199092_2_v_0_ddx5_human RummaGEO Gene Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7797-11A-01R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K88441035 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21335 MPZL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00377022 PDE2A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00603583 GTEX-PLZ4-0006-SM-2S1NY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.845289 BRD-K96799727_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_MCF10A.TP53.M_24H:I04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.20933 PMC11167905-10194_2024_1805_MOESM1_ESM.xlsx-S6-Table_S6_MR_results_of_brain_eQTLs_and_migraine_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null FOXP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.5901 superficial stratum of r10Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1681 BRD-K10900122 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43987 Nucleus of the solitary tract, gelatinous part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.0219 Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.167 GTEX-WFON-1726-SM-4LVMQ GTEx Tissue Sample Gene Expression Profiles 1.0 2.16242 GlobusPallidus BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.19197 disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.046806 Acute Myeloid Leukemia_LAML_TCGA-AB-2862-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 4384_KIF20A_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.05959 Lobules IV-V, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05696 free-living state TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.811 SUZ12-18974828-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null CYP2S1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15219 MRPL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10517 NCIH196 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.54963 H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null USP6NL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31602 BRD-U60236422_WH-4-025_BT20_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE62843,GSE64370_4_v_3_furan_mouse RummaGEO Drug Perturbation Signatures 1.0 null liver HPA Tissue Gene Expression Profiles 1.0 1.41424 SUZ12-20075857-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null TRA2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34052 hsa-miR-4645-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 layer 1 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.20225 CCK81 DepMap CRISPR Gene Dependency 1.0 2.94087 FOXP4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.7565 GSE217363_6_v_1_nlrp3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung adenocarcinoma_LUAD_TCGA-53-A4EZ-01A-12R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GJC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98627 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PMC8410083-elife-65574-fig7-data1.xlsx-KLF10_network-Unnamed_25_KLF10 Rummagene Transcription Factor Associations 2026 1.0 null SNB19 BioGPS Cell Line Gene Expression Profiles -1.0 -2.35675 MYBL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.1853 SATB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.2625 orbital frontal cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01711 GSE223893_11_v_9_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE226249_0_v_7_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K05222558 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07828 STK32A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00582107 H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC1500 CCLE Cell Line Gene CNV Profiles 1.0 2.18616 GTEX-S4P3-0526-SM-4AD58 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21684 ETV2::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.3838 r10 part of basolateral reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3027 hsa-miR-4753-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.257113 hsa-miR-4265 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 1083_NEPRO_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.09565 Liver-liver dendritic cell Tabula Sapiens Gene-Cell Associations 1.0 -0.107235 RGS5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0104104 Homocysteine S-methyltransferase InterPro Predicted Protein Domain Annotations 1.0 null BRD-K37760996 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.52257 bed nucleus of the stria terminalis, laterocentral division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04379 BRD-K29661539 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62907 lateral wings of the dorsal raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2046 dorsolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.85076 GTEX-P4PQ-0005-SM-2HMKJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42664 Brain Lower Grade Glioma_LGG_TCGA-DU-A5TT-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RNF2-16625203-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null cellular amino acid metabolic process GO Biological Process Annotations 2015 1.0 null BRD-K17232330 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.92492 placenta HPA Tissue Gene Expression Profiles -1.0 -1.02444 Glycine cleavage complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.226 BRD-K09295900_delta1-hydrocortisone 21-hemisuccinate_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-VUSG-0006-SM-3GIK9 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 NDUFA8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00585341 hsa-miR-4498 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 GTEX-SIU7-0001-SM-3NMAW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.967471 Aleurone layer TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.647 7498_RPS10_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.05243 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7245-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HL-60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.00656 H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PEBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64743 Pituitary BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.906645 6844_PSMA4_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 3.70599 ChIP_H3K27me3_17603471_mouseESC ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null organonitrogen compound biosynthetic process GO Biological Process Annotations 2015 1.0 null POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null betaine-homocysteine s-methyltransferase activity GO Molecular Function Annotations 2015 1.0 null ZNF816 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22715 inner CP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.910263 RSPH9 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00507445 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5877-11A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RXRA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00600058 Acute Kidney Injury CTD Gene-Disease Associations 1.0 1.2821 temporal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.830164 GTEX-OOBK-2025-SM-3LK5S GTEx Tissue Sample Gene Expression Profiles 1.0 0.836324 hsa-miR-5096 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10X-11A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TTLL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63108 BRD-K85525164 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42757 mantle zone of Hb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15313 BRD-K19946529 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.49977 mediodorsal nucleus of thalamus_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.23263 H3K4me3_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BDH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98812 cellular aromatic compound metabolic process GO Biological Process Annotations 2015 1.0 null BRD-K06956503_NCGC00187945-01_A375_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTSA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0100713 BRD-K76400756 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68445 paraventricular nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.969357 r11 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06267 autoimmune disease of gastrointestinal tract DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.15948 extracellular membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null RNF123 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.485 EDN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00321022 Fibrosis CTD Gene-Disease Associations 1.0 1.12254 single-organism metabolic process GO Biological Process Annotations 2015 1.0 null MTF2-20144788-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-46-3769-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POU5F1B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.2042 BRD-K59369769_tozasertib_MCF7_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K22185032 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10513 GTEX-OOBJ-2026-SM-3NB1R GTEx Tissue Sample Gene Expression Profiles 1.0 0.880376 EP300 ENCODE Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7596-01A-11R-2232-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-TKQ2-1826-SM-33HB2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12159 ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NKX1-1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24709 GTEX-WK11-0006-SM-3NB3J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55247 KMRC3 CCLE Cell Line Gene CNV Profiles 1.0 1.36367 GSE216538_1_v_3_mrs2_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K09878843 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.09502 PDCD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36035 HNF1A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.1466 GTEX-UPK5-0006-SM-3GAD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0224 BRD-A09961470 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07846 ROBO3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.13972 cefotiam-2458 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-OHPM-0726-SM-3LK7A GTEx Tissue Sample Gene Expression Profiles 1.0 1.54943 Skin Cutaneous Melanoma_SKCM_TCGA-GF-A6C8-06A-12R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POU1F1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00557017 inferior olive, dorsal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.28998 GTEX-P4PQ-0726-SM-3NMCR GTEx Tissue Sample Gene Expression Profiles 1.0 1.11895 FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null subbrachial nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23045 BRD-K04853698_LDN-193189_BT20_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null liver GTEx Tissue Gene Expression Profiles 1.0 1.43259 CRCGN015_HEPG2_48H:J10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.65859 KPNA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41441 BRD-K91467861 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24405 abnormality of the integument GWASdb SNP-Phenotype Associations 1.0 0.083306 Carcinoma, Hepatocellular CTD Gene-Disease Associations 1.0 1.35012 anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.58039 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7091-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of r7Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40357 FOXO6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.0656 Crus I, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13546 GSE237040_0_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-Q2AI-0326-SM-2I3EK GTEx Tissue Sample Gene Expression Profiles 1.0 0.975024 GTEX-POMQ-0006-SM-33HBY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.879723 Head and Neck squamous cell carcinoma_HNSC_TCGA-RS-A6TO-01A-32R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K94145457 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.53044 GSE125862_2_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_8415_KO_Cd302_SRP230435 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.6055 H3K27me3_cardiac mesoderm_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K05128360 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.00809 Pyramus (VIII) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18822 SNU1544 DepMap CRISPR Gene Dependency 1.0 4.02647 TMEM59L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54809 lytic vacuole LOCATE Curated Protein Localization Annotations 1.0 null GTEX-WEY5-0001-SM-3P61Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33242 GTEX-WFJO-0005-SM-3GIKY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15164 TBX5-21415370-HL-1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null aspartate family amino acid biosynthetic process GO Biological Process Annotations 2015 1.0 null H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K49424866 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04664 Perturb_11318_KO_Nr1d1/Nr1d2_SRP241717 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.71051 H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null snps GeneRIF Biological Term Annotations 1.0 null GTEX-WXYG-0005-SM-3NB3M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54081 BRD-K63606607_-666_PHH_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung adenocarcinoma_LUAD_TCGA-95-7043-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-3616-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 MM1S DepMap CRISPR Gene Dependency 1.0 5.00818 Hemispheric regions Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00025 carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052276 Uvula (IX), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41364 Pyramus (VIII), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09945 Brain - Amygdala GTEx Tissue Gene Expression Profiles 2023 1.0 3.01441 H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CDK13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03041 GSE151412_2_v_3_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null metyrapone-4606 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE70499_5_v_7_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE226249_5_v_4_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RXF393 BioGPS Cell Line Gene Expression Profiles 1.0 1.06029 intermediate stratum of DG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00025 GLI1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00709049 GSE227592_10_v_1_adar_human RummaGEO Gene Perturbation Signatures -1.0 null TAF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K94775036 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04329 PMC4531812-13058_2015_618_MOESM11_ESM.xlsx-Metabric_Sparse_KM_976-TFAP2B_TFAP2B Rummagene Transcription Factor Associations 2026 1.0 null TNFRSF4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00688167 H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.18893 Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5EB-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IRF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82794 intermediate stratum of r10Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.69549 Succinate dehydrogenase complex (ubiquinone) COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.096 BRD-K57138551 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24253 GTEX-S341-0226-SM-2XCAX GTEx Tissue Sample Gene Expression Profiles 1.0 0.943265 GTEX-SNOS-0226-SM-32PLR GTEx Tissue Sample Gene Expression Profiles 1.0 0.930109 pentetrazol-2255 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RPS6KB2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0107673 hsa-miR-1253 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 pipemidic acid-3093 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K80568112 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17569 CEBPG LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0154516 SKOV3 Achilles Cell Line Gene Essentiality Profiles 1.0 1.14552 CRCGN015_HEPG2_48H:G04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.27092 CRCGN017_MCF10A.WT.HP_24H:I19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.8016 BRD-K97086564 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14693 GTEX-S4Z8-0726-SM-4GICB GTEx Tissue Sample Gene Expression Profiles 1.0 1.58012 small molecule biosynthetic process GO Biological Process Annotations 2015 1.0 null H2AB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8037 GSE152937_12_v_1_slc16a13_mouse RummaGEO Gene Perturbation Signatures 1.0 null TRIM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89866 lateral reticular nucleus (principal part) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03139 germ layer TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.072927 oxybuprocaine-4115 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null LENG8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4806 MDAMB415 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.907781 Viscus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 lung cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05972 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A819-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K90694955 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02246 substantia nigra, pars compacta, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.12059 kidney cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.066982 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A195-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN017_MCF10A.TP53.M_24H:C17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.32715 GTEX-U4B1-0626-SM-3DB8L GTEx Tissue Sample Gene Expression Profiles 1.0 1.13272 GTEX-SJXC-0005-SM-2XCE7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29932 BRD-K61022988 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.21114 BRD-K16686330 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1159 BRD-K13390322_AT-7519_A549_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Hyperhomocysteinemia HuGE Navigator Gene-Phenotype Associations 1.0 null Inflammation CTD Gene-Disease Associations 1.0 1.6036 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1QB-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K49865102_PD-0325901_HCC515_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K19220233_JNK-9L_SKBR3_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Formate dehydrogenase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.989 RCC4 CCLE Cell Line Gene Expression Profiles 1.0 2.18666 HCC1493 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.25945 BRD-K11251396 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.97704 CRCGN015_HEPG2_48H:M22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.16907 GTEX-S95S-0005-SM-2XCEC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03842 BRD-K30548577 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21839 GTEX-UPIC-0626-SM-4IHK2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.40262 Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUV-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WEY5-1926-SM-3GIL8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04261 Perturb_5925_KD_LOXL1_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -10.2775 NCI-H2228 GDSC Cell Line Gene Expression Profiles 1.0 1.61649 PMC5918774-13287_2018_864_MOESM2_ESM.xls-sheet-hREPC_AND_AF_MSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null CTBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44154 BRD-K23503923 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.00373 mantle zone of r10BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30433 GTEX-PWOO-1026-SM-48TCN GTEx Tissue Sample Gene Expression Profiles 1.0 0.921512 BRD-K76829357 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10869 supraoptic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.33189 OAW28 CCLE Cell Line Gene CNV Profiles -1.0 -2.00953 BRD-K04731905 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19613 TMEM52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47065 primary metabolic process GO Biological Process Annotations 2015 1.0 null C1orf74 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27437 A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_1day-MOI-10^4_None_GSE44441 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.15548 GTEX-X3Y1-0006-SM-3P5ZG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13541 GSE87299_2_v_3_nr1d1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-NFK9-0006-SM-3GACS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10052 BRD-K58964288 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.18652 MMP10 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00769022 GTEX-NFK9-0426-SM-2YUNK GTEx Tissue Sample Gene Expression Profiles 1.0 0.843306 carcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054365 GSE157594_6_v_4_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null EZH2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OOBK-0005-SM-2YUMG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09637 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 MKN7 COSMIC Cell Line Gene Mutation Profiles 1.0 null Cotyledon TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.228 BRD-K34274486 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19463 organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.853927 BRD-K82194980 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.64726 SNU685 DepMap CRISPR Gene Dependency 1.0 2.86326 HOXD9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.4456 membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null amygdalostriatal transition area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.18934 dorsal part of alar p2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15553 Urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 H3K27ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K08702524 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61571 H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 UBE2D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17068 felodipine-6695 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MAFK_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NU-DUL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.19301 BRD-K12281552 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22023 TDRD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.9205 RXFP4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00555823 a11 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.715 BRD-K28079391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.62493 Jun JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.9162 posterior part of anterior hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45091 ranitidine-2251 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL2-Unnamed_0_TAL2 Rummagene Transcription Factor Associations 2026 1.0 null H3K27me3_erythroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU685 CCLE Cell Line Gene CNV Profiles 1.0 2.08889 GTEX-T6MN-1226-SM-3NMA5 GTEx Tissue Sample Gene Expression Profiles 1.0 2.64143 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IL-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PLXNC1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00766183 lymphnode_5a HPA Tissue Sample Gene Expression Profiles -1.0 -0.893949 H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K17674993_Diflorasone Diacetate_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_DLX4 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-Q2AH-1026-SM-48TZI GTEx Tissue Sample Gene Expression Profiles 1.0 1.41991 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.437205 PMC4183535__F4 PFOCR Pathway Figure Associations 2023 1.0 null Fatty Liver CTD Gene-Disease Associations 1.0 1.48479 Microphthalmia with limb anomalies DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.264 ESRRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.4451 BRD-K92378241 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19238 epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05211 BRD-K63252672 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43182 Acetaminophen CTD Gene-Chemical Interactions 1.0 null atherosclerosis GAD Gene-Disease Associations 1.0 null H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC7532671-thnov10p10957s2.xlsx-Table_S6A-Table_S6A_Differentially_expressed_genes_DEGs_in_DDX5_KD_versus_WT_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7097-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QV44-1026-SM-447CG GTEx Tissue Sample Gene Expression Profiles 1.0 0.848772 BRD-K51017127 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39822 Perturb_8706_KD_SIRT1_SRP267968 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.38771 BRD-K63711467 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08931 Protein storage vacuole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.563 PRPS2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00643433 GTEX-XUZC-0326-SM-4BOO8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.999995 hsa-miR-761 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 BRD-K66896657 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.73978 PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL1-Unnamed_0_TAL1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K32164935_TOLAZAMIDE_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null carboxylic acid biosynthetic process GO Biological Process Annotations 2015 1.0 null palate GeneRIF Biological Term Annotations 1.0 null DNASE1L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56096 intermediate stratum of isLim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53638 NCIH2347 CCLE Cell Line Gene CNV Profiles 1.0 1.64989 PMC5817105-thnov08p0972s2.xls-SIX3_LSD1-GeneName_SIX3 Rummagene Transcription Factor Associations 2026 1.0 null oxoacid metabolic process GO Biological Process Annotations 2015 1.0 null 6843_PSMA3_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 3.9553 SNU1079 DepMap CRISPR Gene Dependency 1.0 3.43651 A204 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.12696 developmental GAD High Level Gene-Disease Associations 1.0 0.303208 Autosomal dominant cutis laxa DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.38 Cleft Lip CTD Gene-Disease Associations 1.0 2.88009 Lung adenocarcinoma_LUAD_TCGA-78-7167-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-ENSG_LTF Rummagene Transcription Factor Associations 2026 1.0 null HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PITX3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00536438 abnormality of the urinary system GWASdb SNP-Phenotype Associations 1.0 1.09906 aortic aneurysm DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.328105 BRD-K38694430 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.9919 Acute Myeloid Leukemia_LAML_TCGA-AB-2966-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer IIIu of area 35r Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.25733 GTEX-WYVS-0006-SM-3NMA7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05745 Brain Lower Grade Glioma_LGG_TCGA-DU-5847-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null endocrine gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 abducens motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.68104 Perturb_11257_KO_Pparg_SRP294559 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 ROM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47017 Blood and toenail selenium levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 3.8699 SUPT20H LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00540479 COLO 741 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.853927 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.305 BRD-K27849471 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39812 BRD-K96839404 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1367 organic acid biosynthetic process GO Biological Process Annotations 2015 1.0 null KCTD12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50772 BRD-K89932793 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.11424 BRD-K87080069 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10512 IV Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.06456 TUHR4TKB CCLE Cell Line Gene Expression Profiles 1.0 1.3917 hsa-miR-4322 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GPX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52893 GSE77108_8_v_1_saha_human RummaGEO Drug Perturbation Signatures -1.0 null lateral mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.844734 BRD-K40266835 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.84254 DGUOK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49457 MAFF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K67092184 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34491 ABHD17C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37783 CRCGN011_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.41355 mRNA_SOX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12006 BRD-K74750574 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06409 bonemarrow_6b HPA Tissue Sample Gene Expression Profiles -1.0 -2.07549 PANC0504 CCLE Cell Line Gene CNV Profiles -1.0 -1.97887 BRD-K35936801 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39674 L-methionine biosynthetic process GO Biological Process Annotations 2025 1.0 null 6853_PSMB5_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 3.92784 Anterior olfactory nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41787 artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.062951 CRCGN016_MCF10A.WT.HP_24H:K06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.28681 DMS153 CCLE Cell Line Gene CNV Profiles -1.0 -1.62132 GOT2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00587252 gossypol-3740 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CORO1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75024 BRD-K39649723 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41479 H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null mRNA_KLF4_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null STK11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82039 PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST12-Unnamed_8_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null Atherosclerosis HuGE Navigator Gene-Phenotype Associations 1.0 null NOTCH_INHIBITION_GDS2794_61_human_MOLT4 (T-cell acute lymphoblast leukemia) cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null PLPP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46097 GSE180321_0_v_1_imperatorin_human RummaGEO Drug Perturbation Signatures 1.0 null SET2 CCLE Cell Line Gene CNV Profiles -1.0 -1.69564 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4864-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07139 midbrain raphe nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.36673 r10 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.77781 BRD-K94194278 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11888 GM2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11516 KLF9_Deficiency_GDS2703_647_mouse_Jejuna - intestine GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null 20421987-TableS4 GeneSigDB Published Gene Signatures 1.0 null LB2241-RCC GDSC Cell Line Gene Expression Profiles 1.0 1.71934 endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null s-adenosylmethionine-homocysteine s-methyltransferase activity GO Molecular Function Annotations 2015 1.0 null GTEX-TMZS-0001-SM-3P61Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15877 anterior (rostral) cingulate (medial prefrontal) cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.932211 GSE238116_1_v_2_egr1_human RummaGEO Gene Perturbation Signatures 1.0 null CTSS LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00585629 6862_PSMC5_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.80101 OLIG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13044 GSE213632_1_v_5_acod1_mouse RummaGEO Gene Perturbation Signatures 1.0 null spinalcordlower BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.17536 HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.28285 CHMP4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22219 VIIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.93564 SG in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.40901 Congenital heart disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.397 BRD-K90673570 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14349 GTEX-QLQW-0005-SM-2S1RA GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 COLO 678 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13541 BRD-K06956443 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.2007 GTEX-TML8-0005-SM-32QPA GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 GTEX-OXRO-0006-SM-2I5EM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.948011 digestive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null hsa-miR-4311 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5982-11A-01R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_2_CTCF Rummagene Transcription Factor Associations 2026 1.0 null Vascular tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.266 BRD-K40255344_EI-215_PHH_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5884-11A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMG6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50819 GSE248858_1_v_2_tcpobop_mouse RummaGEO Drug Perturbation Signatures -1.0 null S100A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74397 GTEX-PLZ5-0326-SM-3P614 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2793 TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.8891 BRD-K19161227 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42277 BRD-K04495110 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41278 TAF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80961 H3K27me3_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE168596_2_v_3_adiponectin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Endometriosis HuGE Navigator Gene-Phenotype Associations 1.0 null MTMR14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75913 496100462_PCx_dementia_TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.34123 CRCGN014_HEPG2_3H:E07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.00035 rs12325817 GeneRIF Biological Term Annotations 1.0 null ARF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57003 BRD-K28320832 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55988 GTEX-NFK9-1226-SM-3LK79 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08259 GSE186647,GSE217288_2_v_4_hnrnpc_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RWSA-1426-SM-47JXA GTEx Tissue Sample Gene Expression Profiles 1.0 2.06924 GTEX-SIU8-0006-SM-2XCE5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 PMC9618568-41467_2022_34255_MOESM4_ESM.xlsx-TAL1-Unnamed_0_TAL1 Rummagene Transcription Factor Associations 2026 1.0 null MDAMB453 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.990746 VCAM1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00661676 GTEX-X4XY-0006-SM-46MV2 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 hsa-miR-4492 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 S-methylmethionine metabolic process GO Biological Process Annotations 2025 1.0 null Forestomach TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.143 Allograft rejection WikiPathways Pathways 2024 1.0 null BRD-K98170574 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65397 Photosystem II COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.341 BRD-K35780971 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35399 Glutamate synthase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.831 GTEX-WCDI-0002-SM-3P61U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29841 Primary somatosensory area, lower limb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28313 Crus II, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.923211 Acute Myeloid Leukemia_LAML_TCGA-AB-2819-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE174735_4_v_3_il22_mouse RummaGEO Gene Perturbation Signatures -1.0 null Precancerous Conditions CTD Gene-Disease Associations 1.0 1.24496 ChIP_SUZ12_18974828 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null CEBPD ENCODE Transcription Factor Targets 1.0 null erythroid cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.171306 NLRX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41186 BRD-K46195730 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16878 BRD-K23905877 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.10113 H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null immune system disease GWASdb SNP-Disease Associations 1.0 0.052381 gracile nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.34227 BRD-K36764343 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60852 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29X-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TOX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0421 H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WFON-0005-SM-3NMC9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04344 METTL16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72314 sulfathiazole-4769 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H1930 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.04378 Vegetative stage TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.549 TT CCLE Cell Line Gene Expression Profiles -1.0 -2.0789 GTEX-X4EO-0006-SM-3P5ZF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.830536 r10 part of spinal trigeminal nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43229 GSE239436,GSE239441_0_v_1_keap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.138 VIIAt Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.05807 GSE74251_0_v_3_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.23784 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.76 Nucleus sagulum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05597 alitretinoin_homo sapiens_gpl6480_gse43090 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19B-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95262 Hyperplasia CTD Gene-Disease Associations 1.0 1.24087 496100448_TCx_possible Alzheimer's disease_no TBI_88_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.05199 BRD-K93611325 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05698 Field CA3, stratum oriens Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01755 FSCN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19424 T84 DepMap CRISPR Gene Dependency 1.0 3.4158 H3K4me1_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null V Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.966209 BRD-K51677086_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE158197_6_v_10_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null DEL CCLE Cell Line Gene CNV Profiles 1.0 1.48818 SW 982 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.47724 GTEX-U3ZG-0001-SM-47JYF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19156 YAPC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.927562 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZQ-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XBED-0006-SM-47JXO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02919 Kidney TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 LMTK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63914 small molecule metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-OOBJ-0826-SM-3NB2K GTEx Tissue Sample Gene Expression Profiles 1.0 2.39124 GTEX-P78B-0226-SM-3NB1Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.909743 Vascular bundle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.484 wortmannin-2703 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null plant-type cell wall COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.386 GTEX-SNOS-0006-SM-32PLH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08684 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RM-01A-21R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null amygdaloid complex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.31846 leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064168 GTEX-S7PM-0006-SM-3NM8C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00653 H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CECR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.925 5244_MRPS14_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.56885 amino acid metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.506507 hsa-miR-433 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 6856_PSMB7_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.62088 hepg2 HPA Cell Line Gene Expression Profiles 1.0 1.42635 BRD-K98451611 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34572 kidney TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Prefoldin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.699 H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE138818_1_v_0_nanog_mouse RummaGEO Gene Perturbation Signatures 1.0 null plant-type vacuole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.082 GTEX-U8XE-0826-SM-4E3J1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02663 GSE210655_3_v_0_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null VPS37B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40876 Palate TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.431 ACVRL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0056127 H3K4me2_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null magnocellular division of VA Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.22684 APP Pathway Commons Protein-Protein Interactions 1.0 null K029AX CCLE Cell Line Gene Expression Profiles -1.0 -1.45522 BRD-K10799896_clobetasol_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null LCTL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49616 FOXD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.35 Anterior cingulate area, dorsal part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.3104 hsa-miR-3665 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 apoplexy; brain ischemia; stroke GAD Gene-Disease Associations 1.0 null Medial habenula Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.83313 liver_c HPA Tissue Sample Gene Expression Profiles 1.0 1.31772 GTEX-RM2N-0626-SM-48FD6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09929 PRDM8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32539 Lung adenocarcinoma_LUAD_TCGA-55-8094-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11732233-mmc1.pdf-426-ZNF254_ZNF254 Rummagene Transcription Factor Associations 2026 1.0 null molecular layer of S Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1304 GTEX-WHSE-0006-SM-3NMBW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.967383 H3K4me3_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HLA-DPA1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00678004 nclp GeneRIF Biological Term Annotations 1.0 null PLD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04502 H3K4me3_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K66270896 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26376 MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17029 ETV5::FOXO1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.9338 166_ADRM1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.00234 periventricular stratum of r7Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20777 nadolol-3020 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null ARID3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UBTF ENCODE Transcription Factor Targets 1.0 null GTEX-XUJ4-0005-SM-4BOQ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5626 hsa-miR-4722-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 sulfur amino acid biosynthetic process GO Biological Process Annotations 2015 1.0 null GSE144838_1_v_8_egfr_mouse RummaGEO Gene Perturbation Signatures 1.0 null Microspore TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.852 BRD-K38131403 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07633 APRT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59319 t30-blood-rna_female_2w MoTrPAC Rat Endurance Exercise Training -1.0 -17.8873 Perturb_10352_KO_AATF_SRP257744 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.49718 PGRMC1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00324229 GRIN2D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18321 Bacterial microcompartment COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.507 CP in caudal hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2063 PIAS1_Depletion_GDS5076_12_human_MDA-MB 231 breast cancer cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Tongue-schwann cell Tabula Sapiens Gene-Cell Associations 1.0 -0.104376 HCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.852722 Liver TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-RUSQ-0226-SM-47JWT GTEx Tissue Sample Gene Expression Profiles 1.0 0.927567 GTEX-OHPK-0006-SM-2HMKH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45763 GTEX-U3ZM-0002-SM-3NMDM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09332 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7406-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PX3G-0006-SM-33HBQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.968906 GTEX-RNOR-1426-SM-48FDJ GTEx Tissue Sample Gene Expression Profiles 1.0 2.73057 RNF225 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48202 GTEX-UJMC-1026-SM-4IHKN GTEx Tissue Sample Gene Expression Profiles 1.0 0.87288 primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.1893 Simple lobule, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.15187 BRD-K79619334 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01116 L-1210 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.94 medial pallium (hippocampal allocortex) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04379 BRD-K16940345 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29022 pparg_21068720_macrophage_c57bl6_lof_mouse_gpl1261_gds4370 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.766861 cleft GeneRIF Biological Term Annotations 1.0 null GTEX-OXRP-0226-SM-3NB14 GTEx Tissue Sample Gene Expression Profiles 1.0 1.24146 ATF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77652 HCC2218 Achilles Cell Line Gene Essentiality Profiles 1.0 1.27437 Lung-fibroblast Tabula Sapiens Gene-Cell Associations 1.0 -0.107593 VCAP Achilles Cell Line Gene Essentiality Profiles 1.0 3.11154 BRD-K50157358 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2604 CDKN2AIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40793 CTCFL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.2374 mantle zone of r10BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05822 Endosperm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.51 H3K27me3_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null superficial stratum of r11Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06493 Cleft palate DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.891 Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6090-11A-01R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RPF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48794 Leaf epidermis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.239 CTSB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00309732 CRCGN016_MCF10A.TP53.M_24H:P23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.16495 GSE216538_1_v_6_mrs2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Hydathode TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.713 BRD-K53356402 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.10085 BCAT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39934 thyroid gland HPA Tissue Protein Expression Profiles 1.0 1.24683 Lung squamous cell carcinoma_LUSC_TCGA-66-2756-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CLIC3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00719681 Overnutrition DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.14 GTEX-SE5C-1326-SM-4BRUH GTEx Tissue Sample Gene Expression Profiles 1.0 1.16747 BRD-K77814566 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68618 LIVF001-028 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0372 SNU489 CCLE Cell Line Gene CNV Profiles 1.0 1.48818 GTEX-O5YT-0726-SM-3MJHA GTEx Tissue Sample Gene Expression Profiles 1.0 1.25889 GSE202603_0_v_2_bhlhe40_mouse RummaGEO Gene Perturbation Signatures -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M8-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GEMIN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67732 Digestive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SK-BR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.915499 GSE162276_2_v_3_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures 1.0 null NDOR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70715 Stomodeum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.831 BRD-K07600484 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30009 GTEX-N7MS-0007-SM-2D7W1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27415 EPHB2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00420691 GSE174735_1_v_3_il22_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-4520a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 EZH2_DEPLETION_GDS2445_117_human_embryonic fibroblasts GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null PMC12169532-pone.0325700.s010.xlsx-Table_S4-Table_S4_List_of_genes_that_upon_knockdown_KD_led_to_transcriptional_signitures_similar_to_the_input_DEG_set_of_CRC_or_LIHC_and_their_KEGG_enrichment_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K27me3_cardiac mesoderm_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K71799949_carbamazepine_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC3644282-1471-2164-14-110-S3.xls-Contextual_Gene_Set_Ref_Can-SRCAP_SRCAP Rummagene Transcription Factor Associations 2026 1.0 null Kidney Chromophobe_KICH_TCGA-KL-8326-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.09 Middle lamella COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.603 Metabolite levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 3.21549 epithalamus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.397222 benzthiazide-2989 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K73427605 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06232 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4FB-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STAT3_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.7103 GTEX-PWN1-0226-SM-2S1OZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.29688 GTEX-RWS6-0005-SM-2XCAN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.947393 H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE112763,GSE112767_2_v_1_dgcr8_mouse RummaGEO Gene Perturbation Signatures 1.0 null ENOSF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64729 Perturb_5882_KD_EZH2_SRP106792 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 KYSE-410 GDSC Cell Line Gene Expression Profiles -1.0 -2.17262 H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K67844266_MLN4924_HT29_24.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null plant-type vacuole membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.035 GTEX-WHPG-0006-SM-3NMBV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17065 GSE234340_3_v_7_muc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K52310606 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40726 182_AGBL5_P1 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.30894 BRD-K37764012_PF-3758309_HCC515_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A01759464 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.42211 SLC16A7+ cell_Lung_Human CellMarker Gene-Cell Type Associations 1.0 null BRD-K67844266_MLN4924_HA1E_24.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Liver bud hepatic cell_Liver_Human CellMarker Gene-Cell Type Associations 1.0 null GSE184087_4_v_1_tert_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K13390322_AT-7519_PC3_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-OXRL-0726-SM-3NM9A GTEx Tissue Sample Gene Expression Profiles 1.0 0.996569 GSE149760_0_v_1_elof1_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN014_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.63903 IV, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.61347 SKMG1 DepMap CRISPR Gene Dependency 1.0 6.54204 inner CP in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.996701 IKBKE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47456 3-isopropylmalate dehydratase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.871 RNASEH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95822 s-adenosylmethionine metabolic process GO Biological Process Annotations 2015 1.0 null JHU029 DepMap CRISPR Gene Dependency 1.0 3.06642 ZNF322 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42377 GTEX-OXRN-0005-SM-2I5EU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.928599 MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.909557 HAPLN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00552308 GTEX-XXEK-0004-SM-4BRWO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4725 GTEX-UPIC-0005-SM-3GACV GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 ECC12 GDSC Cell Line Gene Expression Profiles 1.0 2.22082 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7434-11A-01R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Spina Bifida DisGeNET Gene-Disease Associations 1.0 null BRD-K54179521 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19135 DUSP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00497059 Cyclin D2-CDK4 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.656 BHMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9015 GTEX-V955-1026-SM-4JBHO GTEx Tissue Sample Gene Expression Profiles 1.0 1.01191 Glycine encephalopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.166 H3K27me3_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterodorsal nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.2286 external part of AOV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17735 reticulocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.320956 H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K33106058_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-X4LF-0006-SM-3NMCO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06811 SPR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.22167 Mouselcells TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.006 orbital frontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.937908 GATA3 JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-XOT4-0005-SM-4B64S GTEx Tissue Sample Gene Expression Profiles -1.0 -0.930531 GTEX-REY6-1226-SM-48FDR GTEx Tissue Sample Gene Expression Profiles 1.0 1.77068 TRIM27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77031 NCIH2004RT DepMap CRISPR Gene Dependency 1.0 3.89688 GTEX-VUSG-1126-SM-4KKZQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.28365 bronchogenic carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064003 BRD-K22915992 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.93958 6861_PSMC4_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.888 BRD-K40116023 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.06642 Uterine Carcinosarcoma_UCS_TCGA-N5-A4RM-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF471 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49761 intermediate stratum of r7BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17506 CCL19 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00843781 BRD-K24950073 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15696 NR2C2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69322 GTEX-V1D1-1226-SM-4JBI5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.942312 ZNF675 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.9796 RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.969295 NCI-H2347 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26628 TOV21G Achilles Cell Line Gene Essentiality Profiles -1.0 -1.18079 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A77P-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:F04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.34889 PPARA-22158963-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null COV504 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.852722 GSE242367_1_v_0_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null H4K8ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HDAC2 ENCODE Transcription Factor Targets 1.0 null BRD-A46747628_-666_PHH_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.23803 cellular amino acid biosynthetic process GO Biological Process Annotations 2015 1.0 null BRD-K29466595 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11432 CRCGN014_HEPG2_3H:P22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.57014 BRD-K68507560_-666_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 18593951-TableS2 GeneSigDB Published Gene Signatures 1.0 null GTEX-X585-0005-SM-46MV3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.962433 UNC13A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23932 NATD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78399 hsa-miR-4659a-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TWIST1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.1268 phentolamine-2362 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K28522188 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02116 Tcf12 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.4607 SU8686 CCLE Cell Line Gene Expression Profiles -1.0 -1.56308 cellular metabolic compound salvage GO Biological Process Annotations 2015 1.0 null kidney GTEx Tissue Gene Expression Profiles 1.0 1.39176 KYSE-270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.966364 CRCGN016_MCF10A.TP53.M_24H:M01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3775 GSE224096_3_v_0_cocaine_human RummaGEO Drug Perturbation Signatures 1.0 null Ammon's horn Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45276 cleft palate DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.31537 BRD-K37459038 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.53907 Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SK-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210842_3_v_1_hnf4a_mouse RummaGEO Gene Perturbation Signatures -1.0 null Primary somatosensory area, lower limb, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.73165 Excretory gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Lung adenocarcinoma_LUAD_TCGA-55-8085-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_Neurosphere Cultured Cells Cortex Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null midline nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.48997 large intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058024 S-methyltransferase activity GO Molecular Function Annotations 2025 1.0 null BRD-K46121327 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12171 C1QTNF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76628 H3K9me3_U2OS_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K99252563_QL-XII-47_SKBR3_3_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PAPOLB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86258 GTEX-R55F-1226-SM-2TF59 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.835925 SUZ12-18974828-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC12422825-aging-17-8-206293-s003.xlsx-i_MR_IP-Unnamed_5_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null CCDC177 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11927 Simple lobule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.15814 BRD-K10221669 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54598 PEMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72622 fat_x1.V2 HPA Tissue Sample Gene Expression Profiles 1.0 0.955016 496100516_FWM_probable Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.21252 GTEX-OIZI-1326-SM-3NB1B GTEx Tissue Sample Gene Expression Profiles 1.0 1.04453 Periventricular hypothalamic nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06194 VI Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.3856 Starch utilization system complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.967 GSE129389_0_v_4_tropifexor_mouse RummaGEO Drug Perturbation Signatures -1.0 null BRD-A19500257_geldanamycin_BT20_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me2_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SLC3A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98643 prednisolone_mus musculus_gpl1261_gse21048 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-T5JW-1426-SM-4DM5Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.47269 Digestive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 CD79B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90974 HRH2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00612174 BEN CCLE Cell Line Gene Expression Profiles 1.0 1.87616 GSE157594_5_v_2_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null SLVL DepMap CRISPR Gene Dependency 1.0 3.03535 vitamin c_homo sapiens_gpl570_gds3635 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-UPIC-1126-SM-4IHLO GTEx Tissue Sample Gene Expression Profiles 1.0 1.95445 BACH1 ENCODE Transcription Factor Targets 1.0 null pineal body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23194 whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 LXR-22292898-THP-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4Z8-0526-SM-4AD4T GTEx Tissue Sample Gene Expression Profiles 1.0 2.25718 mediodorsal nucleus of thalamus_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.15831 GTEX-OOBK-2626-SM-2HMKY GTEx Tissue Sample Gene Expression Profiles 1.0 0.886745 BRD-K05673000_dicloxacillin_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Primary visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38168 ZFP57 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6619 QGP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.864074 Viscus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 ATP1A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.004326 Oxoglutarate dehydrogenase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.995 GTEX-Q2AI-0006-SM-2I3FG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07544 occipital pole, left, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.36927 PNP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00410256 phenazopyridine-6100 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K85985071_E3380_PHH_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Petiole TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.664 superficial stratum of r7BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05019 BRD-K44722555 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01589 GTEX-T8EM-0226-SM-3DB7C GTEx Tissue Sample Gene Expression Profiles 1.0 0.948404 nrf1_22586274_liver_lof_mouse_gpl4134_gse35124 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.004616 H3K9ac_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EPOR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96372 EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Trimethylammonioacetate HMDB Metabolites of Enzymes 1.0 null HN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.966364 SP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.89175 POLR2A_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-G5-6572-02A-12R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K46588240 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.987 EPHA4_drugactivation_229_GSE26523 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.97167 GSE112763,GSE112767_4_v_5_dgcr8_mouse RummaGEO Gene Perturbation Signatures 1.0 null ASPC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.834173 lung cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.0612 TRPC6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00331775 TBX20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12984 NAP1L4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00471941 BETAINE DGIdb Drug Targets 2026 1.0 26.466 Methionine CTD Gene-Chemical Interactions 1.0 null TRIM69 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0060169 extracellular region part GO Cellular Component Annotations 2015 1.0 null 6777_PRMT5_P1 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.22796 HMC cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.611 ETV5::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.3644 GTEX-WOFL-0006-SM-3TW8K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13151 neural tube TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.924623 HOXB5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.3725 Chloroplast COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.649 FADS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17728 6874_PSMD6_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.58775 beta-galactosidase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.696 Acute Myeloid Leukemia_LAML_TCGA-AB-2938-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K16251850 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.75396 MANSC1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00612835 NALM16 DepMap CRISPR Gene Dependency 1.0 2.87804 GTEX-QLQ7-0005-SM-2S1QP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03606 GSE207158_0_v_1_poldip2_human RummaGEO Gene Perturbation Signatures -1.0 null NFIC_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUM1315MO2 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.832543 GTEX-VUSG-0003-SM-3NMDK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55411 molecular_function GO Molecular Function Annotations 2015 1.0 null VIIIA, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.06548 PHOX2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.0406 NOTCH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.191 DU-145 COSMIC Cell Line Gene Mutation Profiles 1.0 null LDAH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07479 THBS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17429 Field CA2, stratum lacunosum-moleculare Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.74355 Eye-ocular surface cell Tabula Sapiens Gene-Cell Associations 1.0 -0.103662 6963_PWP2_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.07845 alpha4-beta1 integrin-JAM2 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.329 GTEX-XPT6-0001-SM-4B64G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4182 Mandibular organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.951 PMC4686057-pone.0145107.s001.xlsx-PAA-CAA-Unnamed_0_TSHZ1 Rummagene Transcription Factor Associations 2026 1.0 null TMUB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98075 EFNA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2899 medial habenular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.31127 BRD-K81363924 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17641 lateral hypothalamic area, anterior part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14464 PLA2R1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00576719 CNIH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79693 HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.29252 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70R-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11443809-12967_2024_5663_MOESM3_ESM.pdf-114-CRX_CRX Rummagene Transcription Factor Associations 2026 1.0 null SW1116 CCLE Cell Line Gene CNV Profiles 1.0 1.43124 Microgametophyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.779 COTL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49699 Liver Neoplasms, Experimental CTD Gene-Disease Associations 1.0 1.14166 L-Methionine HMDB Metabolites of Enzymes 1.0 null PMC8143797-elife-62857-fig3-data2.xlsx-DEgenes_SW872_TAZ-CAMTA1_vs_EV-Gene_CAMTA1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K28122619 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30919 adult stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.06025 single-organism cellular process GO Biological Process Annotations 2015 1.0 null NR1I2-20693526-LIVER-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K82774801 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13848 MXI1 ENCODE Transcription Factor Targets 1.0 null 15361855-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null supramammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.12876 H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null levocabastine-hcl LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.44205 hsa-miR-4804-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 Caryopsis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.133 RPL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01366 CTCF ENCODE Transcription Factor Targets 1.0 null huh-7 BioGPS Cell Line Gene Expression Profiles 1.0 1.53844 GSE200982_0_v_2_plac8_human RummaGEO Gene Perturbation Signatures -1.0 null CISD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78149 POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ6-0006-SM-33HBZ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 NENF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83874 NCIH1339 CCLE Cell Line Gene CNV Profiles -1.0 -1.58212 BRD-A25869984 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48087 CASP9 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00606292 SKIL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44809 H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U8XE-0005-SM-3DB8I GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46771 BRD-K36149853 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23805 BRD-K35614154 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72809 BRD-K81082552 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49921 GSE157594_0_v_7_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null CAKI-1 GDSC Cell Line Gene Expression Profiles 1.0 1.42077 DAN-G Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.909557 Tapetum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.625 H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WFG7-1026-SM-4LMK8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00849 SLCO1C1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00481556 CRCGN012_HEPG2_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.10422 GTEX-P44H-0006-SM-2XCFB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09833 GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-A94756469_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null periventricular stratum of r6Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07919 STK17B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00516818 BRD-K45153693 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33521 C4orf46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47123 C8166 DepMap CRISPR Gene Dependency 1.0 2.24826 GTEX-QDVN-0826-SM-48TZ2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.54225 ZNF580 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.47541 HDAC5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00618248 H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SCO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6773 CILP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00538634 GOLPH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62112 methylcrotonoyl-CoA carboxylase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.715 BRD-K53757555 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26976 GSE162739_6_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SASH3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00701245 BRD-K52001024 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38305 Artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.108 KLRC3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00608131 POU3F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.6682 hippocampus (hippocampal formation)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.30915 mRNA_ASCL2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTEX-VUSH-0005-SM-3NB2H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23348 sulfur compound metabolic process GO Biological Process Annotations 2015 1.0 null spleen HPA Tissue Gene Expression Profiles -1.0 -0.841776 GTEX-PLZ5-0006-SM-2S1NZ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.3636 Spikelet TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.715 3421_GMIP_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.17041 MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null liver TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-X8HC-0006-SM-46MV6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.927107 BRD-K97707303 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36935 SLC6A8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00548346 Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Lobules IV-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07242 H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE237040_2_v_5_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-UTHO-0011-R11A-SM-3GIJE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.828423 KG1C CCLE Cell Line Gene CNV Profiles 1.0 1.7441 adult TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.308974 Nutrition disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.232 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4622-11A-01R-1758-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null common GeneRIF Biological Term Annotations 1.0 null TAP2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00560848 H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PLZ6-0626-SM-3P61B GTEx Tissue Sample Gene Expression Profiles 1.0 0.997316 GTEX-Q2AH-0005-SM-33HBR GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 BRD-A58937872 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44997 kidney_a HPA Tissue Sample Gene Expression Profiles 1.0 1.67186 HCV JFH1_168Hour-Huh7_None_GSE29889 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.12923 H3K9ac_Adipose Nuclei Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Spinal nucleus of the trigeminal, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07317 EDC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67639 496100405_TCx_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.7074 SLC32A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00742007 paralemniscal isthmic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09672 SW 1116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.9255 digestive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.487496 ONCODG1 CCLE Cell Line Gene Expression Profiles -1.0 -1.62362 Spermidine HMDB Metabolites of Enzymes 1.0 null BRD-K61520618 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76699 H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null supraoptic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.7261 colon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060284 PDHB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00640876 BRD-K26314798 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04107 GTEX-U4B1-0006-SM-3DB8E GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 inferolateral temporal cortex (area TEv, area 20)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.65623 toxin-antitoxin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.83 Paraventricular hypothalamic nucleus, parvicellular division, medial parvicellular part, dorsal zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2038 extracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A48D-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Betaine levels in individuals undergoing cardiac evaluation GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.21549 DBR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2331 lateral part of the lateral habenular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24531 generalized abnormality of skin GWASdb SNP-Phenotype Associations 1.0 0.133696 Uterus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.067 CILK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00702334 GTEX-POMQ-0626-SM-3P61E GTEx Tissue Sample Gene Expression Profiles 1.0 1.15918 Nkx2-1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.4381 NU-DUL-1 COSMIC Cell Line Gene CNV Profiles 1.0 4.51153 organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.33046 BRD-K78837609 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02298 TPI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62999 BRD-K88573743_A443654_HME1_3_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hippocampus (hippocampal formation)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.32299 BRD-K67007076 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11546 BRD-K35128472_CC-100_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GALNTL5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00530536 CRCGN014_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.26 NKX2-5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4113 bromocriptine-5665 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-U61997977_WZ-4-145_BT20_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE146074_10_v_8_ly6e_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K79179851 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.22541 BRD-K12376164 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.84251 BRD-A60245366_AS-601245_A549_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-PW2O-0006-SM-2I3DV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14501 H3K27me3_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ChIP_RNF2_16625203 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Panicle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.088 BRD7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00739742 U178 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.12738 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A6HN-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-TMMY-0526-SM-33HBC GTEx Tissue Sample Gene Expression Profiles 1.0 0.879437 ZBTB7A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SG in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.886728 TRIML2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63116 excretory gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 Photosynthetic membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.478 9672_USP5_P1 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.11042 NCI-H838 COSMIC Cell Line Gene Mutation Profiles 1.0 null PRC2_EZH2_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null Nucleus ambiguus, ventral division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.01175 GTEX-RN64-1626-SM-48FD7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.70439 nilutamide-3104 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null mediodorsal nucleus of thalamus_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.860019 BRD-A98714080 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.01037 mRNA_ESX1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null STAT5A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00573038 Physical disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.755 rilmenidine-6512 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Cleft Palate DisGeNET Gene-Disease Associations 1.0 null marrow cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068264 NCIH522 CCLE Cell Line Gene Expression Profiles -1.0 -2.19526 H3K9me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null SLC35B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43157 Prostate-mast cell Tabula Sapiens Gene-Cell Associations 1.0 -0.10795 membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE240386,GSE242143_1_v_6_morc2_human RummaGEO Gene Perturbation Signatures 1.0 null RMGI Achilles Cell Line Gene Essentiality Profiles -1.0 -1.78096 motor nucleus of trigeminal nerve Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.86857 GTEX-WCDI-0005-SM-3NB2M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56362 GTEX-SNOS-0726-SM-4DM5Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.830986 layer 6a of PrS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.52192 BRD-K45714931 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.01165 propylthiouracil-4157 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE68156_3_v_5_dextran_mouse RummaGEO Drug Perturbation Signatures -1.0 null PMC8844187-Table_2.xlsx-prostate-DLX1_DLX1 Rummagene Transcription Factor Associations 2026 1.0 null TNFAIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92997 Whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 H3K27me3_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF680 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.7183 Secondary motor area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26809 Neural tube defect DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.042 Prostate adenocarcinoma_PRAD_TCGA-EJ-7123-11A-01R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K46348476 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.75351 LU-165 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K19220233_JNK-9L_HCC515_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PTPRK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00458486 extracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 1774_COPG1_P1 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.12631 CORL23 Achilles Cell Line Gene Essentiality Profiles 1.0 1.80935 Cysteine synthase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.673 Steatotic liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.034 BRD-K00265832 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.9632 Lung squamous cell carcinoma_LUSC_TCGA-39-5034-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 KURAMOCHI Achilles Cell Line Gene Essentiality Profiles 1.0 1.41215 17555561-Table1 GeneSigDB Published Gene Signatures 1.0 null GTEX-N7MT-0007-SM-3GACQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.849609 ZBTB7A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AGK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00738141 H3K4me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-NL3H-0006-SM-2I3FW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.943987 Acute Myeloid Leukemia_LAML_TCGA-AB-2995-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10934 RAPGEF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95265 MSC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.8279 TMEM258 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0051066 Anencephaly DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.337 Lung adenocarcinoma_LUAD_TCGA-55-8091-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF1 ENCODE Transcription Factor Targets 1.0 null SP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77759 CUL7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44457 vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.305226 PLC/PRF/5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06002 Small_Intestine-gut endothelial cell Tabula Sapiens Gene-Cell Associations 1.0 -0.107235 VRK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22328 Lobules IV-V, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08497 GSE226249_5_v_7_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null GSE86507,GSE86509_4_v_1_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null adipose tissue TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.824656 OV7 Achilles Cell Line Gene Essentiality Profiles 1.0 1.93851 PMC8437976-41416_2021_1470_MOESM2_ESM.xls-List_of_MAF_in_SNP_Rectum-Hugo_Symbol_MAF Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XMD3-0006-SM-4AT5X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12566 BRD-K66715657 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05889 ITPKC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62407 H3K27me3_cardiac mesoderm_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null anabasine-6074 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TARM1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00693228 H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MS4A10 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00579408 significant GeneRIF Biological Term Annotations 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-5936-01A-11R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE194396,GSE194429_2_v_3_atrx_human RummaGEO Gene Perturbation Signatures -1.0 null ZNF16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.6999 BRD-K13087974_D3943_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TSC1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.01069 GSE223241_1_v_3_cdkn2a_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-T5JC-0001-SM-3NMAK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1282 basolateral nucleus (basal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.859494 BRD-K39326623 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7067 BRD-K52854560 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18623 BRD-K15474464 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25805 HOXA6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.8803 ZNF417 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.5716 epithelioma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052176 PPP1R1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10454 GTEX-PWOO-0006-SM-2I3E3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22752 PMC12198892-pi-2025-0101-Supplementary-Material.pdf-6-BAZ2B_BAZ2B Rummagene Transcription Factor Associations 2026 1.0 null SW626 COSMIC Cell Line Gene Mutation Profiles 1.0 null CREB3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.5078 GTEX-RWSA-0226-SM-2XCBA GTEx Tissue Sample Gene Expression Profiles 1.0 1.03376 GTEX-QDT8-0006-SM-32PL3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.884299 urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053981 HLA-B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5514 Liver-t cell Tabula Sapiens Gene-Cell Associations 1.0 -0.106163 fibroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.062303 BRD-K69252983 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12415 CRCGN014_HEPG2_3H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.14295 A2058 COSMIC Cell Line Gene Mutation Profiles 1.0 null APP_KO_GDS4414_370_mouse_prefrontal cortex GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-XQ8I-0006-SM-4BOQ5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11158 COLO678 CCLE Cell Line Gene CNV Profiles 1.0 2.36386 H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RXF393 GDSC Cell Line Gene Expression Profiles 1.0 1.486 hematopoietic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055779 Plastoglobule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.536 ARHGAP27 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00593253 Adrenocortical carcinoma_ACC_TCGA-OR-A5LH-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CYB5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76506 GTEX-UTHO-2426-SM-4JBHD GTEx Tissue Sample Gene Expression Profiles 1.0 1.56555 cos cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.192315 r9 part of external cuneate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.19883 Ornithine carbamoyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.201 superficial stratum of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45683 abnormality of skin physiology GWASdb SNP-Phenotype Associations 1.0 0.253791 ZNF227 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20543 METTL27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.07377 amino-acid betaine metabolic process GO Biological Process Annotations 2015 1.0 null BRD-K26251149 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40865 cell part LOCATE Curated Protein Localization Annotations 1.0 null BRD-K81669067 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78738 lidocaine-4421 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-6030-11A-01R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DCAF17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51062 BEN GDSC Cell Line Gene Expression Profiles 1.0 1.42762 r1 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01755 TCF25 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00395633 BRD-K06264262 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20209 HNRNPA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69445 CRCGN010_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.61137 Sulfur amino acid metabolism Reactome Pathways 2024 1.0 null NCI-H2171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.51926 BRD-K05070188 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04303 Lung squamous cell carcinoma_LUSC_TCGA-70-6723-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posteroventral (inferior) parietal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.945607 NCI-H2804 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.852722 BRD-K44458042 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.54552 H3K27me3_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Lymph_Node-stromal cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0825773 Starch grain COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.961 ARID4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81512 POR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00768479 TP63 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.8276 H3K4me3_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K76353834 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.09818 H3K9me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SUCS-0006-SM-4DM59 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.39277 RERFLCSQ1 DepMap CRISPR Gene Dependency 1.0 3.08114 Transnitrosylase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.64 GTEX-OIZI-0005-SM-2XCED GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null mRNA_ZSCAN4C_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null S100P LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00542349 Liver-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 -0.107235 IZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.97201 C8orf33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53003 spleen GTEx Tissue Gene Expression Profiles -1.0 -1.18331 SW1573 CCLE Cell Line Gene CNV Profiles 1.0 2.59998 HL60 CCLE Cell Line Gene CNV Profiles -1.0 -1.83609 intermediate stratum of r9Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.53279 Nucleus ambiguus, dorsal division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01581 integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051554 CRCGN017_MCF10A.WT.HP_24H:O08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3094 ZNF267 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47511 superficial stratum of r8Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07695 Thylakoid COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.475 disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.036486 RFX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.3151 Stroke HuGE Navigator Gene-Phenotype Associations 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5550-01A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_11195_KO_Pparg_SRP294559 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 8.10894 PKDCC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03562 Skin Cutaneous Melanoma_SKCM_TCGA-D9-A3Z3-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K26992703 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.40616 periventricular stratum of IC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06043 GTEX-UPK5-1326-SM-4IHLE GTEx Tissue Sample Gene Expression Profiles 1.0 1.19547 GTEX-WYJK-0326-SM-3NMA8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.872972 SUV39H2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85478 anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.989277 Homocysteine HMDB Metabolites of Enzymes 1.0 null CDK12 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00688877 MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16897 COPS8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18368 SCN4B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00465898 Primary somatosensory area, barrel field, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45426 MAX ENCODE Transcription Factor Targets 1.0 null GTEX-S3XE-0006-SM-3K2AA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.880139 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K05339908 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06275 BRD-K39983086_loteprednol_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null metabolic GAD High Level Gene-Disease Associations 1.0 0.293278 GTEX-W5X1-0001-SM-3P61V GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29791 GSE202017,GSE202018_1_v_0_mettl3_human RummaGEO Gene Perturbation Signatures -1.0 null LI7 CCLE Cell Line Gene Expression Profiles 1.0 1.76269 TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null GSE214183_1_v_0_phf8_human RummaGEO Gene Perturbation Signatures 1.0 null normoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.171306 hsa-miR-3605-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 Renal glomerular cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.559 LIPE_KO_GDS1318_501_mouse_muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null respiratory system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054462 Gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 minocycline-2405 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null raphe obscurus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.950268 KOSC-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-PR-A5PH-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 10297_ZNF335_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.11046 HEXIM1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00827208 mRNA_SMAD7_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null CRCGN015_MCF10A.TP53.M_24H:A07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.06395 acetylsalicylic acid-5201 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K72435943 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11099 HLF Achilles Cell Line Gene Essentiality Profiles -1.0 -1.04484 EHMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92291 superficial part of arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.87094 BRD-K26122955 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3181 periventricular stratum of Hb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05089 BRD-K12202458 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32107 LB996-RCC GDSC Cell Line Gene Expression Profiles 1.0 2.33069 r10 part of external cuneate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.46419 SLR24 CCLE Cell Line Gene Expression Profiles 1.0 1.64113 ECSCR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59844 GTEX-TML8-1326-SM-4DXTO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.833099 H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K79090631_CGP-60474_PC3_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_MCF10A.WT.HP_24H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7542 Field CA1, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10729 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5971-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PPARA_agonist activation_GSE17250_475_mouse_Isolated hepatocytes GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null HT55 COSMIC Cell Line Gene Mutation Profiles 1.0 null CDKL4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00832267 JAK2_knockdown_192_GSE54645 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.8044 ventrolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.937908 GTEX-WH7G-0005-SM-3NMBX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56321 H3K9me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TCAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45263 CHD2 ENCODE Transcription Factor Targets 1.0 null GALM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20911 SG in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.992219 BRD-K68143200_-666_EFO27_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cellular metabolic process GO Biological Process Annotations 2015 1.0 null JIMT1 CCLE Cell Line Gene CNV Profiles -1.0 -2.81805 H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HS294T DepMap CRISPR Gene Dependency 1.0 3.0298 BRD-K58193973 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05453 BRD-K12107215 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40957 H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K86848211 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22558 6871_PSMD3_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.79695 PCBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01867 GTEX-OHPN-0226-SM-48TBV GTEx Tissue Sample Gene Expression Profiles 1.0 0.979223 TUBB3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00713956 mediodorsal nucleus of thalamus_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.21026 ZCCHC12 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00501537 GSE162276_2_v_0_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null Mesothelioma_MESO_TCGA-SC-A6LR-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null kanamycin-5686 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RELL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00544719 GTEX-T6MN-1526-SM-4DM5P GTEx Tissue Sample Gene Expression Profiles 1.0 0.875775 GTEX-S7SF-0001-SM-3K2BE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03964 amino-acid betaine metabolic process GO Biological Process Annotations 2023 1.0 null H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATP6V1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01301 TYK-NU.CP-R Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.90952 HT1197 Achilles Cell Line Gene Essentiality Profiles 1.0 1.19183 GTEX-X5EB-0004-SM-46MWA GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 Prostate adenocarcinoma_PRAD_TCGA-G9-6348-11A-01R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RNF212 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00586569 C19orf73 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67323 MOLM-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.34993 ZBED6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.72652 ACHN BioGPS Cell Line Gene Expression Profiles -1.0 -1.14792 Prostate adenocarcinoma_PRAD_TCGA-KC-A4BR-01A-32R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K40248932 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35769 ESS1 DepMap CRISPR Gene Dependency 1.0 2.03172 purine ribonucleoside metabolic process GO Biological Process Annotations 2015 1.0 null YY1_Deficiency_GDS4856_318_mouse_Soleus skeletal muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null TMEM256 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62057 Nfe2l2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.0868 GTEX-OIZF-0006-SM-2I5GQ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 LS1034 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10267 Ebolavirus(ZEBOV)_3day_PBMCs_rNAPc2treated_21987740_GSE24943 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -0.109848 PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-gene_name_LTF Rummagene Transcription Factor Associations 2026 1.0 null BACH1-22875853-HELA-AND-SCP4-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null S-methylmethionine metabolic process GO Biological Process Annotations 2023 1.0 null GTEX-WY7C-0006-SM-3NB3L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31602 ENHO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81647 MZ in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.904305 Lung adenocarcinoma_LUAD_TCGA-05-4418-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAF::NFE2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.9413 ENTPD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22295 CTCF_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A816-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-43-2581-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WL46-3026-SM-3LK7Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.826444 COLO 829 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.965458 Field CA1, stratum radiatum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07972 nih 3T3 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.50798 TMEM140 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27842 mRNA_CDX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTEX-XGQ4-0005-SM-4AT5U GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 APLNR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00514795 posterior hypothalamic area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.887748 H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NPB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81711 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.372217 Phloem TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.512 CEBPD_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of r9Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07919 BRD-K06750613_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null LIVF001-013 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.04728 H3K27me3_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PHF19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63966 Lung squamous cell carcinoma_LUSC_TCGA-21-1083-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF354C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35692 Lysosomal storage disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.01 pharmacogenomic GAD High Level Gene-Disease Associations 1.0 0.293278 H3K27me3_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pineal gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.445268 organonitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null BRD-K63919349 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35144 PCDHB5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55891 VIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.827622 BRD-K10798676 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14831 DU4475 DepMap CRISPR Gene Dependency 1.0 4.65039 CRCGN014_HEPG2_3H:I12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.74162 Calcinosis HuGE Navigator Gene-Phenotype Associations 1.0 null SMCR8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.92235 Lung adenocarcinoma_LUAD_TCGA-62-8397-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HBA1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0051111 Cytochrome o ubiquinol oxidase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.544 GTEX-WVLH-0006-SM-3MJF7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00029 HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.9083 JIMT-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -3.15041 SNCA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00593649 Nucleus of the solitary tract, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33846 MET_knockout_253_GSE30651 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.19895 LMCD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.19843 Prostate adenocarcinoma_PRAD_TCGA-EJ-7328-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Posterior parietal association areas, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0999 Mesophyll cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.944 Tongue-endothelial cell of lymphatic vessel Tabula Sapiens Gene-Cell Associations 1.0 -0.106878 SUV39H2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.005198 MEF2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.5058 cellular nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null abnormality of the skin GWASdb SNP-Phenotype Associations 1.0 0.102325 r9 part of trigeminal transition zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06788 GSE198165,GSE198166_6_v_10_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null intracellular part LOCATE Curated Protein Localization Annotations 1.0 null GTEX-SUCS-0002-SM-3NMAJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34134 hsa-miR-4659b-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 GSE244072_4_v_6_tfeb_mouse RummaGEO Gene Perturbation Signatures -1.0 null medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.266 LMX1B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.955 GTEX-S4Q7-0003-SM-3NM8M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.911635 BRD-K78431006_crizotinib_BT20_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Fetallung BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.16152 496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.39848 BRD-K29395450_PIK-93_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TNFRSF8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0058085 Uvula (IX) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41283 indoprofen-3007 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PSMG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2836 ASAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18934 GSE199092_3_v_0_ddx5_human RummaGEO Gene Perturbation Signatures -1.0 null Inferior colliculus, external nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.35022 EHMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87654 superficial stratum of Hb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24283 substantia nigra, compact part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.34742 BRD-K29794647 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01428 ventromedial hypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.03551 intracellular membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null Pyramus (VIII), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30187 GTEX-XPT6-0006-SM-4B66Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07473 orbital frontal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.24014 NURR1 MotifMap Predicted Transcription Factor Targets 1.0 null Mammary-endothelial cell of lymphatic vessel Tabula Sapiens Gene-Cell Associations 1.0 -0.105091 Connective tissue TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Leaf lamina TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.255 G3BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33874 CSGALNACT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25121 H3K27me3_cardiac mesoderm_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null lomefloxacin-4745 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Primary somatosensory area, trunk, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.25232 Cell Transformation, Neoplastic CTD Gene-Disease Associations 1.0 1.09576 nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null hsa-miR-616 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R3RS-0005-SM-3GAEH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.9473 RNF2-16625203-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PPP1R18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66802 STARD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29109 Lung adenocarcinoma_LUAD_TCGA-97-A4LX-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null B4GALT3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00844201 GSE216538_1_v_4_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null tolmetin-3009 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE203584_1_v_0_cisplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null RNF128 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00825216 GSE228894_3_v_2_rnmt_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K72261386 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37961 RORA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.2011 H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QLQ7-1526-SM-2S1QA GTEx Tissue Sample Gene Expression Profiles 1.0 0.825799 BRD-A99164655_Dihydrexidine hydrochloride_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MAP4K5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3428 BRD-K13390322_AT-7519_HEPG2_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null mafenide-5079 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K67689282 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.73762 mantle zone of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45769 TK10 BioGPS Cell Line Gene Expression Profiles 1.0 0.9672 L33 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.37172 BRD-K83180232 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06643 PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XUJ4-0004-SM-4BOQE GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 functionally GeneRIF Biological Term Annotations 1.0 null Trans sulfuration one carbon metabolism and related pathways WikiPathways Pathways 2024 1.0 null GSE226249_5_v_8_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2754-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OC314 DepMap CRISPR Gene Dependency 1.0 3.20628 HCC70 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.722862 G111 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16897 BRD-K68174511_torin-2_HA1E_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null transferase activity, transferring one-carbon groups GO Molecular Function Annotations 2015 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7793-11A-01R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K79090631_CGP-60474_A375_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null solitary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.829062 BRD-K82021299 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50148 TNNT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6236 r8 part of linear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.67932 SNU-475 GDSC Cell Line Gene Expression Profiles 1.0 1.60138 ATG16L1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00636339 PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-ensembl_LTF Rummagene Transcription Factor Associations 2026 1.0 null Anterior olfactory nucleus, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32613 PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-DMOG_-_HIF1A-gene_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null periaqueductal gray substance, dorsolateral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.829366 BRD-K89558221_-666_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null dorsolateral IC periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06119 AR ChEA Transcription Factor Targets 1.0 null BRD-A89337244_-666_PHH_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TCL1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00498167 CXorf38 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52222 GTEX-OXRL-2626-SM-2I3F1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.871399 GTEX-TKQ1-0126-SM-33HB3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04677 Pollen tube TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.619 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 PADI3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00511095 cleft lip; cleft palate GAD Gene-Disease Associations 1.0 null BRD-K88671309 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43556 H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UPK5-1426-SM-4JBHH GTEx Tissue Sample Gene Expression Profiles 1.0 1.98898 PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Symbol_FOXM1 Rummagene Transcription Factor Associations 2026 1.0 null superficial stratum of DG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61283 GSE146074_9_v_11_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null CBX8 ENCODE Transcription Factor Targets 1.0 null Perturb_11852_OE_Ccne1_SRP185695 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.98297 locus ceruleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.8123 NUPR1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00575014 VIIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.96468 BRD-A95442017 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16149 Lip disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.82 Adrenocortical carcinoma_ACC_TCGA-OR-A5JF-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SALL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00480427 GABRQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99516 lymphocytic leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.089477 WERIRB1 DepMap CRISPR Gene Dependency 1.0 6.36123 FUCA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06291 GSE238116_3_v_0_egr1_human RummaGEO Gene Perturbation Signatures 1.0 null LETMD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93015 NCI-H2347 GDSC Cell Line Gene Expression Profiles 1.0 1.42181 Lung-adventitial cell Tabula Sapiens Gene-Cell Associations 1.0 -0.105806 EGR1 ENCODE Transcription Factor Targets 1.0 null cytoplasmic part LOCATE Curated Protein Localization Annotations 1.0 null ATP13A3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00460657 medial mammillary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.49543 GTEX-XMK1-1126-SM-4IHJ8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.22362 Primary visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13942 6858_PSMC2_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 3.59716 Field CA1, stratum lacunosum-moleculare Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.9551 bonemarrow_5a HPA Tissue Sample Gene Expression Profiles -1.0 -2.07549 Pancreas-pancreatic pp cell Tabula Sapiens Gene-Cell Associations 1.0 -0.10795 Adrenocortical carcinoma_ACC_TCGA-OR-A5JX-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null methionine salvage HumanCyc Pathways 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-5899-01A-11R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AGFG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6325 H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE226249_0_v_4_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-V1D1-0006-SM-3NMCE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62761 GTEX-XV7Q-1026-SM-4BRVR GTEx Tissue Sample Gene Expression Profiles 1.0 1.29208 H3K4me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K40210962 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53185 RPAP3/R2TP/prefoldin-like complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.685 COLO741 CCLE Cell Line Gene CNV Profiles -1.0 -1.43283 Field CA2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02448 Coronary Artery Disease HuGE Navigator Gene-Phenotype Associations 1.0 null SON_KD_GDS4448_35_human_HeLa GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2935-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin - Sun Exposed (Lower leg) GTEx Tissue Gene Expression Profiles 2023 1.0 2.49335 BRD-K47441131 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.30942 RELA_01_30 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.59128 PMC8656035-40001_2021_613_MOESM2_ESM.docx-11-ZNF827_ZNF827 Rummagene Transcription Factor Associations 2026 1.0 null RRP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32243 GTEX-U3ZN-1626-SM-4DXTZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.843374 Selenium Measurement DisGeNET Gene-Phenotype Associations 1.0 null GCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49307 MFSD2A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00576071 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5891-11A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K34531548 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12193 BRD-K74305673_-666_PHH_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAPAN-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.852722 IGR39 CCLE Cell Line Gene CNV Profiles 1.0 1.79102 BRD-K07615667 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.63458 CRCGN015_MCF10A_48H:A07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.00155 GTEX-WHPG-0004-SM-3NMDO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41945 STX1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22435 paraventricular nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.39658 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 hsa-miR-4430 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 BRD-K49865102_PD-0325901_HME1_3_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_258_KD_PBRM1_SRP358304 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 13.4864 SLC6A13 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00514187 ENSG00000230707 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36834 Anterior cingulate area, ventral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.93414 H3K27me3_megakaryocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.65602 HNF1B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.5777 BRD-K03406345_azacitidine_A375_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U412-0006-SM-3DB8J GTEx Tissue Sample Gene Expression Profiles -1.0 -0.949302 H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null LHX1_KO_GDS2748_298_mouse_embryonic renal vesicles GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K98143437_SB-239063_HEPG2_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VJWN-0005-SM-3GIKF GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 hsa-miR-4309 TargetScan Predicted Conserved microRNA Targets 1.0 1.11641 8710_TBC1D1_ENST00000261439.4 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.56003 RNPEPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.587 H3K9me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null organelle LOCATE Curated Protein Localization Annotations 1.0 null YY1 JASPAR Predicted Transcription Factor Targets 1.0 null amygdaloid complex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.92262 GTEX-Q734-0006-SM-2I3FJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.964013 GTEX-SN8G-0001-SM-3NM8L GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 BRD-K81647747 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00302 GSE210655_3_v_2_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE158197_2_v_3_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null Congenital nonspherocytic hemolytic anemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.222 parabigeminal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11049 PMC10282096-41467_2023_39038_MOESM4_ESM.xlsx-All_genes_Upregulated-ENSG00000177426_TGIF1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K81949875 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5937 Hippocampal region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5954 BRD-K42489623_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null propranolol-3059 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null medial septal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.90469 Lung squamous cell carcinoma_LUSC_TCGA-52-7812-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE188774_1_v_0_hkdc1_human RummaGEO Gene Perturbation Signatures 1.0 null r9 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.00358 BRD-K20799008 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30376 GTEX-OOBJ-0006-SM-2I3F4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3946 GSE158458_2_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.900851 MAPK8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00643645 HCC2218 CCLE Cell Line Gene CNV Profiles 1.0 1.36768 SPIN2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65284 HSD17B6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0064487 LGE-VZ border region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03448 BRD-K90571714 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43022 GTEX-S95S-0326-SM-4B66U GTEx Tissue Sample Gene Expression Profiles 1.0 0.949616 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5683-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MMP27 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00627216 lateral orbital frontal cortex (area 12/47) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.86273 BRD-K03848296 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46671 BRD-K39342915 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.76775 Lung adenocarcinoma_LUAD_TCGA-99-8033-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GM97 BioGPS Cell Line Gene Expression Profiles 1.0 0.857093 GTEX-U8XE-1526-SM-4E3HT GTEx Tissue Sample Gene Expression Profiles 1.0 1.28331 Sclerenchyma TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.008 cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 bhmt2 GeneRIF Biological Term Annotations 1.0 null BRD-K13445266 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12113 celiac disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.20658 NF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70707 6869_PSMD1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.92127 GSE237040_0_v_5_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20R-11A-11R-A16R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE68156_0_v_5_dextran_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-PVOW-0006-SM-3NMB8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00293 Gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.272 Spina bifida DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.858 GTEX-X88G-0006-SM-47JX5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 GSE197342_1_v_0_berberine_mouse RummaGEO Drug Perturbation Signatures 1.0 null risedronate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.88758 GTEX-QCQG-0006-SM-2S1OW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.930135 RAI2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00482391 NCIH2228 CCLE Cell Line Gene CNV Profiles 1.0 1.44239 B4GALNT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1503 SLC47A2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00623962 PCSK1N CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92717 BRD-K16266179 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.76187 BRD-K01643633 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02194 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81R-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K20420220 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78407 Sarcoma_SARC_TCGA-FX-A2QS-11A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE226770_1_v_6_atrx_human RummaGEO Gene Perturbation Signatures -1.0 null HNF4alpha_KO_GDS1916_168_mouse_Embryonic liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null dorsal thalamus_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.0284 IDH3B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0077314 GTEX-OXRK-0426-SM-3NB2E GTEx Tissue Sample Gene Expression Profiles 1.0 1.16561 Acquired metabolic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.21 Complement component 4a deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.578 ventrolateral preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4274 GTEX-RWS6-2426-SM-2XCB9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.84164 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.641 MG-63 COSMIC Cell Line Gene Mutation Profiles 1.0 null A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_4day-MOI-10^4_None_GSE43301 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.43204 Phosphopantothenoylcysteine decarboxylase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.126 sulfur compound biosynthetic process GO Biological Process Annotations 2015 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FW-A5DX-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GPI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96769 dorsomedial preoptic area, superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0078 HLA-DRB1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00667241 TFAP2E JASPAR Predicted Human Transcription Factor Targets 2025 1.0 60.3479 intermediate stratum of r10BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30353 globus pallidus, internal segment, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.825082 lung TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054922 LPIN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49587 H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null cinchocaine-1469 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K51572611 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53081 RAI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67333 Myosin XI complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.7 9679_UTP11_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.26086 UBTF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ACTR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32837 GTEX-XUZC-0526-SM-4BOPF GTEx Tissue Sample Gene Expression Profiles 1.0 1.05257 BRD-K47482563 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.87871 LRIT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00604128 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20N-11A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE226249_2_v_1_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.471 BRD-K03262163 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.64145 PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null VIIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.05417 JR DepMap CRISPR Gene Dependency 1.0 2.50589 BRD-K86111620 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.83298 Lignin network COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.428 Lung adenocarcinoma_LUAD_TCGA-97-8179-01A-11R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QDVJ-0005-SM-2TC5X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05178 posteroventral (inferior) parietal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.8664 FOXK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.6771 REST_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular_component LOCATE Curated Protein Localization Annotations 1.0 null BRD-A05635986 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50449 GSE233679_14_v_7_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null STOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64437 H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4776-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GSE122101,GSE122103_3_v_4_ssu72_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K32176914 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20701 PMC3044438__F3 PFOCR Pathway Figure Associations 2024 1.0 null 6849_PSMB1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.58193 bj HPA Cell Line Gene Expression Profiles 1.0 0.89958 BRD-K32862383 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25031 chr5_79131385_T_A_b38 GTEx eQTL 2025 1.0 1.91388 Nucleus ambiguus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41534 BRD-K57251296 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09833 FLI1::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.4682 GTEX-X88G-0004-SM-47JZ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 BRD-A10134527 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37485 lateral part of r10B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3027 G96 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.04283 GSE184087_0_v_1_tert_human RummaGEO Gene Perturbation Signatures 1.0 null FAM219B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8895 medial habenular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02052 GTEX-PLZ6-1326-SM-3NB24 GTEx Tissue Sample Gene Expression Profiles 1.0 0.858513 r7 part of the basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17735 GTEX-V1D1-0003-SM-3NMDP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36758 spina bifida DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.633956 Primary somatosensory area, unassigned, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00427 BRD-K07959057 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25318 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.31 PMC6639357-41467_2019_11150_MOESM4_ESM.xlsx-SupTab1_Activated_genes_diffex-Supplementary_Data_1_Fold_change_and_p-value_of_all_activated_protein_coding_genes_upon_DNMT1-KO_DNMT1 Rummagene Transcription Factor Associations 2026 1.0 null GSE172020_0_v_3_testosterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null MAX_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLC43A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03362 SKRC20 CCLE Cell Line Gene Expression Profiles 1.0 1.36531 TIA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42744 OLFML3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4405 BRD-K48276655 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.10842 MDAMB415 CCLE Cell Line Gene CNV Profiles 1.0 1.76232 HSF1_KD_GDS1733_755_human_HeLa cells - 0.5 Hour by siHSF1_2 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-XPVG-0526-SM-4B65N GTEx Tissue Sample Gene Expression Profiles 1.0 2.07275 PRMT5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94588 GTEX-REY6-0005-SM-2TF54 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 ZNF410 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.3161 SUZ12 ChEA Transcription Factor Targets 1.0 null Anteromedial visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.75041 BRD-K84391462 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0112 C32TG Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.927562 DMAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15273 GAPDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39396 abnormality of the genitourinary system GWASdb SNP-Phenotype Associations 1.0 0.08248 CRCGN011_HEPG2_24H:B24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.21075 mantle zone of r9Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05087 KDM3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.19628 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K19220233_JNK-9L_A375_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-QLQW-0226-SM-447BJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.01666 primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04497 BRD-K09721123 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21317 BRD-A39996500_radicicol_SKBR3_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null pralidoxim LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.17184 HCC70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00366 GSE158197_0_v_11_egfr_mouse RummaGEO Gene Perturbation Signatures 1.0 null cytoplasmic part GO Cellular Component Annotations 2015 1.0 null hypersensitivity reaction type ii disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.057308 FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.8952 BRD-K61439332 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01567 ILF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76655 MT-ATP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31003 Primary somatosensory area, lower limb, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20356 Liver carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.042 Acute Myeloid Leukemia_LAML_TCGA-AB-2821-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5JS-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anr4 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.276 SPRED3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31735 GTEX-QMRM-1726-SM-2S1QG GTEx Tissue Sample Gene Expression Profiles 1.0 0.938689 BRD-K82671459 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03604 GTEX-TSE9-0005-SM-4DXUF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07621 Glucose metabolism disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.008 GTEX-XV7Q-0226-SM-4BRVL GTEx Tissue Sample Gene Expression Profiles 1.0 0.880326 Cleft Palate HuGE Navigator Gene-Phenotype Associations 1.0 null Fetal Lung Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.28164 VI, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.4264 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8XJ-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null kidney TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 COLGALT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8327 Cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.454 Gas vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.621 stratum oriens of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.864248 outer CP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.27996 BRD-A25736793_everolimus_HCC515_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H-508 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.551 BRD-K36460068 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.68966 GTEX-RWS6-0726-SM-47JXI GTEx Tissue Sample Gene Expression Profiles 1.0 0.831952 Primary somatosensory area, lower limb, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06002 PSMD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00661056 SOX21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.1715 Anteromedial visual area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.35429 MAFF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TPK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00524725 BRD-K43535770 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5606 GTEX-QLQW-0626-SM-447A6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07211 BRD-K84935293 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15875 S-Adenosylmethionine CTD Gene-Chemical Interactions 1.0 null SLC19A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00630871 H3K27me3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RUNX2_NULL MUTATION_GDS2184_719_mouse_Embryonal bone (MG-U74A) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null VN1R1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73595 RYR2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.005436 Mitochondrial fatty acid beta-oxidation multienzyme complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.034 GTEX-UJHI-0006-SM-3DB8H GTEx Tissue Sample Gene Expression Profiles -1.0 -0.919765 CRCGN015_MCF10A.WT.HP_24H:F17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.35616 ARMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66715 posteroventral (inferior) parietal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.93612 BRD-K50140147_NVP-TAE684_SKBR3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-UPJH-0001-SM-3NMDE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.965549 PMC4740183__F3 PFOCR Pathway Figure Associations 2023 1.0 null GTEX-PLZ5-1826-SM-3NB22 GTEx Tissue Sample Gene Expression Profiles 1.0 0.910831 ZNF281 ChEA Transcription Factor Targets 1.0 null BRD-K50300854 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42003 BRD-K41287744 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12756 NCI-H1703 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.985017 GSE172020_1_v_3_testosterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null Perturb_3661_KO_EZH2_SRP211748 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.31575 Mesothelioma_MESO_TCGA-TS-A7P0-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HEC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null CBX8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Storage root TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.536 Aflatoxin B1 CTD Gene-Chemical Interactions 1.0 null LB771HNC DepMap CRISPR Gene Dependency 1.0 2.16475 H3K27me3_CD3 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Crus II, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.12771 Blood trace element (Se levels) GWAS Catalog SNP-Phenotype Associations 2025 1.0 2.70458 rs712012 GeneRIF Biological Term Annotations 1.0 null H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-A456-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Anterior cingulate area, ventral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01558 Disc TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.754 ZBTB7A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K24396733 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66217 nitrofural-2459 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YD-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null erythroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.171306 BRD-K16733272 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05099 GTEX-TKQ1-0006-SM-33HBI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12699 496100522_PCx_dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.33435 rostral presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.21722 GTEX-V1D1-1126-SM-4JBHT GTEx Tissue Sample Gene Expression Profiles 1.0 0.881923 NRF1 JASPAR Predicted Transcription Factor Targets 1.0 null CSNK1G3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0046577 BRD-K86155080 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.5974 GSE70499_3_v_7_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null precommissural nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.21894 superficial stratum of DTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05089 GCGR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00606183 POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_HEPG2_48H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.24398 hypersensitivity reaction disease GWASdb SNP-Disease Associations 1.0 0.650844 BRD-K58688519 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27162 A549 Achilles Cell Line Gene Essentiality Profiles -1.0 -2.42876 Prostate adenocarcinoma_PRAD_TCGA-H9-A6BX-01A-31R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K13461720 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17052 PMC3702285-cddis2013211x6.pdf-29-ZNF268_ZNF268 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K85606544_neratinib_HCC515_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-WHSB-0005-SM-3LK7C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25622 ampyrone-4507 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-Q734-0226-SM-48U1A GTEx Tissue Sample Gene Expression Profiles -1.0 -0.829761 NMUR2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00795568 OGDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35072 HEPG2 BioGPS Cell Line Gene Expression Profiles 1.0 1.26845 UGCG LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00491625 COS-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.913 HEC251 CCLE Cell Line Gene CNV Profiles 1.0 1.39052 ANKEF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35823 pyrophosphate-dependent phosphofructokinase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.745 substantia nigra, pars compacta, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.983971 Acute Myeloid Leukemia_LAML_TCGA-AB-2857-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-TKQ1-0003-SM-3NMAE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44869 MACIR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.32669 yap1_18413746_mcf10a_gof_human_gpl570_gds3220 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.519636 BXPC3 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.34368 GTEX-WFG7-0001-SM-3P61S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32664 GTEX-WRHU-0006-SM-3MJF6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.024 primary auditory cortex (core)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.83998 hsa-miR-3652 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.049861 PLEKHO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92628 extracellular vesicle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.057922 BRD-K79090631_CGP-60474_A549_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A20208638 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51963 NUDT4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32856 neurological GAD High Level Gene-Disease Associations 1.0 0.293278 GSTP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87093 BRD-K01978082 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11984 PMC11442894-41467_2024_52678_MOESM5_ESM.xlsx-all_MSC_vs_iMPC-Unnamed_0_MSC Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN008_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5014 GTEX-R55G-0926-SM-48FDN GTEx Tissue Sample Gene Expression Profiles 1.0 1.09355 PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-ensembl_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XGQ4-0426-SM-4AT4I GTEx Tissue Sample Gene Expression Profiles 1.0 0.841583 GSE227592_8_v_1_adar_human RummaGEO Gene Perturbation Signatures -1.0 null epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05103 EVSA-T COSMIC Cell Line Gene Mutation Profiles 1.0 null lysosome LOCATE Curated Protein Localization Annotations 1.0 null H3K79me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_HEPG2_48H:P13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.95421 urinary system disease GWASdb SNP-Disease Associations 1.0 0.256237 GSE162276_2_v_0_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures 1.0 null spinal dysraphism GAD Gene-Disease Associations 1.0 null BPH1 DepMap CRISPR Gene Dependency 1.0 2.8414 BRD-K41814083 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25738 GSE246461,GSE246463_5_v_0_mecp2_mouse RummaGEO Gene Perturbation Signatures -1.0 null bonemarrow_6c HPA Tissue Sample Gene Expression Profiles -1.0 -1.3578 BRD-A43330902 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49101 Cerebrospinal fluid t-tau levels in mild cognitive impairment GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.669897 Anteromedial visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.71829 hsa-miR-3064-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 suprofen-3005 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCOA1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00592447 ZNF354A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 62.0844 GTEX-PSDG-0726-SM-2I5FN GTEx Tissue Sample Gene Expression Profiles 1.0 0.918467 ACVR2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62299 pretectal nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.976408 Becker GDSC Cell Line Gene Expression Profiles -1.0 -1.99661 primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.36607 Amino acid metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.812 BRD-K63970901 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.11302 BRD-K31834149 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01227 BRD-K45272675 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.80284 SLC31A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70004 MAPKAPK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00349299 GSE193402_0_v_3_imatinib_human RummaGEO Drug Perturbation Signatures -1.0 null EZH2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Anterior group of the dorsal thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08812 NCI-H2595 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23219 GTEX-T6MN-0002-SM-3NMAH GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer 3 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22441 Lung squamous cell carcinoma_LUSC_TCGA-37-5819-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null organic substance metabolic process GO Biological Process Annotations 2015 1.0 null SDHAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79703 PANX1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.005499 periventricular stratum of r8Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.65289 BRD-K79090631_CGP-60474_MDAMB231_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00596873 GTEX-XBEW-1426-SM-4AT4J GTEx Tissue Sample Gene Expression Profiles 1.0 1.35959 GSE216538_0_v_2_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XBEW-0006-SM-4AT4E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.991103 BRD-K37830990 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18918 levobunolol-3015 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-P4PQ-1526-SM-3NMCK GTEx Tissue Sample Gene Expression Profiles 1.0 0.836122 FOXH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.5718 BRD-K82109576_vincristine_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Neoplasms CTD Gene-Disease Associations 1.0 1.0894 MAFA MotifMap Predicted Transcription Factor Targets 1.0 null BRD-K34703146 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15095 TAF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RM2N-0526-SM-2TF4N GTEx Tissue Sample Gene Expression Profiles 1.0 0.97927 maternal GeneRIF Biological Term Annotations 1.0 null Secondary motor area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.71317 p2 portion of the substantia nigra pars reticulata Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04168 YY1 ENCODE Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A4IH-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PX3G-0826-SM-48TZS GTEx Tissue Sample Gene Expression Profiles 1.0 2.29116 colorectum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.0583 BRD-K14245433 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.09399 H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K24132293_piperlongumine (HPLC)_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PFKP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91596 SKMEL5 CCLE Cell Line Gene Expression Profiles -1.0 -1.63444 UMRC2 CCLE Cell Line Gene Expression Profiles 1.0 2.65494 BRD-K87909389_alvocidib_A549_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8519-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZACN LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00519742 paraventricular nucleus, peduncular or principal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01436 GTEX-T6MO-0003-SM-3NMAG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5933 BRD-K36352298 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19118 A704 GDSC Cell Line Gene Expression Profiles 1.0 2.64748 CRCGN017_MCF10A.WT.HP_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.8248 GTEX-RM2N-1126-SM-48FCY GTEx Tissue Sample Gene Expression Profiles 1.0 0.878045 DNPEP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38313 SNU840 CCLE Cell Line Gene Expression Profiles -1.0 -1.56111 TP53_01_31 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.06041 fibroblast cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065519 cos-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.456828 fungal-type cell wall COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.523 GTEX-TMZS-0006-SM-3DB8G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43444 BRD-K99545815_PF-562271_A549_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-RU72-1426-SM-46MUF GTEx Tissue Sample Gene Expression Profiles 1.0 1.9333 Renal outer medulla TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.506 PIAS1_KD_GSE44024_133_human_breast cancer cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-OOBK-0726-SM-3LK5Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.06348 Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H8-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Anterior olfactory nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52341 OVCAR5 BioGPS Cell Line Gene Expression Profiles -1.0 -1.40298 BRD-K63547380 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38232 KOPN-8 COSMIC Cell Line Gene Mutation Profiles 1.0 null amino acid salvage GO Biological Process Annotations 2025 1.0 null GCA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88654 SMAD4 ChEA Transcription Factor Targets 1.0 null PMC8304577__F9 PFOCR Pathway Figure Associations 2024 1.0 null DTX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6097 MTF2 ChEA Transcription Factor Targets 1.0 null Folate transport and metabolism KEGG Pathways 2026 1.0 null GTEX-OXRL-0005-SM-3LK6A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48363 ZFP281-18757296-E14-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null mRNA_ASCL1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTEX-V955-2026-SM-3GAFA GTEx Tissue Sample Gene Expression Profiles 1.0 1.25335 3-methylcrotonyl-CoA carboxylase complex, mitochondrial COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.849 GTEX-XBEW-0126-SM-4AT66 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05672 OVCAR433 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.37414 Lateral dorsal nucleus of thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18125 SG in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.68025 Perturb_4606_KD_H2A.Z_SRP345495 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 pentoxifylline-2290 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_14398_KO_SYK_SRP124678 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 13.3013 GSE128844_0_v_3_chloroquine_human RummaGEO Drug Perturbation Signatures 1.0 null placenta_6c HPA Tissue Sample Gene Expression Profiles -1.0 -1.17572 SW1088 CCLE Cell Line Gene CNV Profiles 1.0 1.73626 H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 metal ion binding GO Molecular Function Annotations 2015 1.0 null POU3F4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.9591 Trichome TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.725 SNU1077 CCLE Cell Line Gene CNV Profiles -1.0 -1.46849 BRD-K17239874 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00219 primary auditory cortex (core)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.70232 GSE159084_0_v_1_dexamethasone_mouse RummaGEO Drug Perturbation Signatures 1.0 null HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01592 H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K16214172 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49027 PMC7934233-13059_2021_2293_MOESM8_ESM.xlsx-Fibroblast_HOXC6-gene_HOXC6 Rummagene Transcription Factor Associations 2026 1.0 null Atf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.6168 H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null BRD-K92301463_-666_LOVO_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-T5JC-0005-SM-4DM7B GTEx Tissue Sample Gene Expression Profiles -1.0 -0.913223 cleft lip DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.39608 SMSCTR DepMap CRISPR Gene Dependency 1.0 16.4931 MTF2-20144788-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K08247496 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1658 BRD-K30103771 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10564 Urinary system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC9160962__F1 PFOCR Pathway Figure Associations 2024 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-4507-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU475 CCLE Cell Line Gene Expression Profiles 1.0 1.45157 BRD-K32049721 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59074 YBX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55276 GTEX-TMZS-0226-SM-3DB9N GTEx Tissue Sample Gene Expression Profiles 1.0 1.06033 Primary somatosensory area, trunk, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.73849 GLYATL2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00621472 OAZ3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00557041 hnf4a_16714383_e18dot5_liver_lof_mouse_gpl1261_gds1916 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 2.00639 GTEX-WFON-0001-SM-3P61W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06805 GSE216538_7_v_4_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null MALME3M CCLE Cell Line Gene CNV Profiles -1.0 -1.52544 BRD-K23793049 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05345 SUOX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51534 GTEX-T6MO-0006-SM-32QOU GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 JAK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05473 striatum_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.36807 Glycoprotein network COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.596 abdominal aortic aneurysm DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.398589 granule cell layer of the DG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1965 CW-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-X15G-0005-SM-3NMDA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29887 P53-21459846-SAOS-2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null EFO21 Achilles Cell Line Gene Essentiality Profiles 1.0 1.20185 BRD-K66282601 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.49822 GTEX-PWO3-0005-SM-2I5FS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03528 kanamycin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18294 Myelomeningocele DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.446 Brain Lower Grade Glioma_LGG_TCGA-P5-A5EY-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MMP23A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00741085 Anterior cingulate area, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05399 BARHL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.4456 GTEX-XOTO-0826-SM-4B65O GTEx Tissue Sample Gene Expression Profiles 1.0 2.02041 CLN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.27907 GSE158853_0_v_1_hmgcs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-S95S-1526-SM-2XCDH GTEx Tissue Sample Gene Expression Profiles 1.0 1.07286 NLRC3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00609519 Apoplast COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.403 FOXO1::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.9028 GTEX-QVUS-0006-SM-3GAE8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45137 intermediate stratum of r10BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.39769 L-methionine sulfoximine-4151 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K07859598_GW-5074_HEPG2_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE176093_0_v_1_mineral oil_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE201657_0_v_1_ash2l_human RummaGEO Gene Perturbation Signatures 1.0 null 1581_CHMP2A_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.71084 ACOT9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40562 DXO LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00627245 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MU-06A-21R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K90902537 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82483 8MGBA DepMap CRISPR Gene Dependency 1.0 2.19009 Caudal regression syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.037 SW1271 CCLE Cell Line Gene Expression Profiles -1.0 -1.47744 GTEX-OHPN-0005-SM-2YUML GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34949 H3K4me3_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8110-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K09975370 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.72832 BRD-K43639523 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.26722 CD46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33966 TLR8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00614755 BRD-K28983467 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30537 CCL11 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00623159 FOXC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.1824 H3K9ac_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SYCE1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16282 cv-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.186281 GSE238116_3_v_2_egr1_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K80332123 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57881 SULT1C4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02975 colonic mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.357058 GTEX-NL3H-0011-R11A-SM-2I3E6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.838439 POLR2J2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14048 BRD-K19220233_JNK-9L_BT20_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NEUROD1_Deficiency_GDS3000_612_mouse_Pineal glands of neonates GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null superficial stratum of r9Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.19651 H3K27me3_erythroblast_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K77634326 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08528 methylation GO Biological Process Annotations 2015 1.0 null MDAMB436 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 2.40471 CEP104 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13199 theobromine-2995 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SLC7A3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00687441 mRNA_T_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Cerebral ganglion TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.607 hsa-miR-3135b TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-XBP1_XBP1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K25284184 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.61106 SR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.47724 VMRCRCZ CCLE Cell Line Gene CNV Profiles -1.0 -1.73081 GTEX-UPK5-0003-SM-3NMDI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53429 GSE152937_12_v_7_slc16a13_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K9me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:P23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.83933 viscus TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 FBLN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67381 DCLRE1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80273 BRD-K11242872 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44069 BRD-K54132860 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1095 GSE226316_0_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures 1.0 null VIIIA, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.96966 BRD-K11437379 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4843 BRD-K30491662 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14646 IKZF2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00743489 TAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01718 intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 anterior olfactory area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45942 GOLIM4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00616392 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Drug-Related Side Effects and Adverse Reactions CTD Gene-Disease Associations 1.0 1.01437 kidney disease GWASdb SNP-Disease Associations 1.0 1.25477 BRD-A07765530_(+/-)-epinephrine_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hippocampus (cortex Ammonis) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06727 SLC38A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00620997 SCA1_Knock-in_GDS1756_231_mouse_Cerebellum tissue - 4 weeks of age GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K50140147_NVP-TAE684_BT20_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CSGALNACT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00687995 RP1_KO_GDS1845_190_mouse_Retinas GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE164508_1_v_0_bortezomib_mouse RummaGEO Drug Perturbation Signatures -1.0 null Medullary reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05748 BRD-K29802952 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49663 GSE70499_5_v_2_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Fetalliver BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.31354 Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3WC-11A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE224969,GSE224971_3_v_9_chtop_mouse RummaGEO Gene Perturbation Signatures 1.0 null Adipose tissue TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Guard cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.088 JUNB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29946 Temporal gyrus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.964 CKM LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00671743 r8 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.60684 BRD-K13390322_AT-7519_A375_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null (+/-)-catechin-3012 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null l-methionine salvage GO Biological Process Annotations 2015 1.0 null GTEX-QESD-0006-SM-2I5G6 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 Field CA2, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.09641 GSE159937_1_v_0_tfcp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null HT144 CCLE Cell Line Gene Expression Profiles -1.0 -2.30795 hyperhomocysteinemia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.689893 mRNA_MEF2C_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null H3K4me3_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZNF792 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60296 spleen_3a HPA Tissue Sample Gene Expression Profiles -1.0 -0.963161 GSE157594_6_v_2_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_HSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null connective tissue TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SERPINH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70129 BRD-K39944607_32937_PHH_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NFYC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.2606 GSE147056_4_v_1_actl6b_mouse RummaGEO Gene Perturbation Signatures -1.0 null ESRRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.2967 BRD-K67950754 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.25232 sulfur amino acid metabolic process GO Biological Process Annotations 2015 1.0 null SNU-182 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.852722 GSE184087_2_v_1_tert_human RummaGEO Gene Perturbation Signatures 1.0 null NUPR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52993 HERC5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00440082 HCC2998 BioGPS Cell Line Gene Expression Profiles -1.0 -1.67096 CDC25A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3536 estradiol_homo sapiens_gpl14550_gse35034 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PABPC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79498 ATIC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00544535 TYK2_KD_GDS4754_158_human_JURKAT GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K88934376 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23277 GTEX-P4PP-0926-SM-48TBZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.929688 Kidney Chromophobe_KICH_TCGA-KN-8433-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE154936_3_v_2_remdesivir_human RummaGEO Drug Perturbation Signatures 1.0 null TNFRSF9 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00770145 SW1271 DepMap CRISPR Gene Dependency 1.0 4.78212 BRD-K25736729 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06773 xth2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.045 cerebellar white matter Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04988 Acute Myeloid Leukemia_LAML_TCGA-AB-3012-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null physical disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.784345 Brain Lower Grade Glioma_LGG_TCGA-DU-8165-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsal motor nucleus of the vagus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.0038 adrenosterone-6486 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Cardiovascular Diseases HuGE Navigator Gene-Phenotype Associations 1.0 null BRD-K39503511_MK-0591_HCC515_6.0_h_80.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Photosystem I COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.233 GTEX-R53T-0326-SM-48FEC GTEx Tissue Sample Gene Expression Profiles 1.0 2.71185 PFN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72507 H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K68065987_MK-2206_BT20_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K85664064 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04591 PDCD6IP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34597 VAMP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18608 LTA4H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0555 BRD-K73808079 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62101 GTEX-WQUQ-0006-SM-3MJF4 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 CTLA4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00524896 GTEX-QV44-0826-SM-2S1RG GTEx Tissue Sample Gene Expression Profiles 1.0 0.83268 PMC4266008-mmc3.xlsx-iPS-MSC_vs_MSC-Unnamed_7_MSC Rummagene Transcription Factor Associations 2026 1.0 null inferior occipital gyrus, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.21614 Silique TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.892 GSE174418,GSE174421_2_v_3_mettl5_mouse RummaGEO Gene Perturbation Signatures 1.0 null KMS-12-PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.71763 GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15245 hsa-miR-548m TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K40219231 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08074 extracellular organelle GO Cellular Component Annotations 2015 1.0 null Secondary cell wall COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.785 H3K27me3_erythroblast_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN009_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4869 PMC10349775-432_2022_4445_MOESM1_ESM.pdf-3-HOXA3_HOXA3 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K22944782 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.57309 BRD-K51153795 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09446 BRD-K64800655_PHA-793887_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hsa-miR-3202 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 POR_KO_GDS1678_763_mouse_Liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null forebrain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058849 GSE140937,GSE140938_1_v_2_slfn11_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K67096761 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.96896 HCV JFH-1_24Hour_20200238_GSE20948 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.46662 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1HY-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-RTLS-0006-SM-2TF58 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 HESX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.7281 Lymph_Node-endothelial cell Tabula Sapiens Gene-Cell Associations 1.0 -0.105091 UBXN11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41911 CYB561D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98696 H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null L-methionine salvage GO Biological Process Annotations 2025 1.0 null H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12061 CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.65805 HCC38 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.45512 ventrolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.32122 nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039668 glycosyl compound metabolic process GO Biological Process Annotations 2015 1.0 null BRD-K35222206 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36661 Serum metabolite levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.8699 membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null L-methionine biosynthetic process GO Biological Process Annotations 2023 1.0 null PIP4K2C LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00907908 PMC7220941-41598_2020_64431_MOESM2_ESM.xlsx-WS1_2019_Affy_IDs_RA-STvsOA-ST-Unnamed_2_PAX3 Rummagene Transcription Factor Associations 2026 1.0 null JHOM1 CCLE Cell Line Gene Expression Profiles -1.0 -1.53795 FLYWCH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67985 H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE193258,GSE193259_9_v_6_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null TGFB1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0055299 MONOMAC6 Achilles Cell Line Gene Essentiality Profiles 1.0 1.15549 GSE200352_11_v_6_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null Disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.527 KMS-12-BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.51926 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5894-11A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 6847_PSMA7_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.82538 BRD-K30217326 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27581 496100368_PCx_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.05241 PABPN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72263 biosynthetic process GO Biological Process Annotations 2015 1.0 null BRD-K64800655_PHA-793887_HCC515_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K82198647 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10991 BRD-K15259298 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.40168 AR-20517297-VCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K89447678 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1672 Oligospermia CTD Gene-Disease Associations 1.0 1.17101 hESC Derived CD184+ Endoderm Cultured Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.31792 AP1G2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55878 hsa-miR-762 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 GTEX-WRHK-0005-SM-3MJF5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48253 BRD-K71123535 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25711 UBTF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1852 NFATC4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.8633 NOLC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81065 BRD-K33583600_ISOLIQUIRITIGENIN_THP1_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN009_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.17845 SELPLG LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00486507 GTEX-XQ8I-1826-SM-4BOOJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.07084 chr5_79074078_A_G_b38 GTEx eQTL 2025 1.0 2.33347 SF295 GDSC Cell Line Gene Expression Profiles -1.0 -2.08303 Anteroventral nucleus of thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10092 CORL51 CCLE Cell Line Gene CNV Profiles -1.0 -1.33705 granular layer of rostral dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.89189 Vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.359 H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RU1J-0006-SM-2TF6M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09917 Eye-plasma cell Tabula Sapiens Gene-Cell Associations 1.0 -0.10795 HOP92 BioGPS Cell Line Gene Expression Profiles -1.0 -0.897265 BRD-K74402642_Chemistry 2804_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XUZC-1826-SM-4BRVO GTEx Tissue Sample Gene Expression Profiles 1.0 1.11909 urinary tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063861 1579_CHMP1A_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.13433 bonemarrow_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.55323 ATP1B2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00648822 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5686-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 769P CCLE Cell Line Gene Expression Profiles 1.0 1.54613 NCIH2228 CCLE Cell Line Gene Expression Profiles 1.0 1.45863 GTEX-WYBS-1926-SM-3NM8N GTEx Tissue Sample Gene Expression Profiles 1.0 0.976778 NR1I2 ChEA Transcription Factor Targets 1.0 null H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K04508260 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32976 Anterior cingulate area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.52445 ventral medial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.42913 HCC4011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.63308 SSU72 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8657 BRD-K78009480 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.62043 intermediate stratum of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48477 BRD-K74948793 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4537 YY1 MotifMap Predicted Transcription Factor Targets 1.0 null L-Methionine DrugBank Drug Targets 1.0 null 786O CCLE Cell Line Gene CNV Profiles -1.0 -1.52827 TRAPPC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99229 urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 Cellulose synthase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.91 BRD-K38617061 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.78299 GSE200352_11_v_3_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-A23193246 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37197 transition metal ion binding GO Molecular Function Annotations 2025 1.0 null FOXP2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.4504 liver TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 Liver hepatocellular carcinoma_LIHC_TCGA-MR-A520-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TIMD4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00665495 H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null coronary GeneRIF Biological Term Annotations 1.0 null BRD-K24680618 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07587 A4-FUK COSMIC Cell Line Gene Mutation Profiles 1.0 null MFE-319 COSMIC Cell Line Gene Mutation Profiles 1.0 null RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VIIB, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.889788 H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01711 PDE3A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00523256 CABLES1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9927 BRD-K06765193_(E)-2-(1H-Benzoimidazol-2-yl)-3-(5-nitro-furan-2-yl)-acrylonitrile BRD-K06765193_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K23984367_sorafenib_BT20_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE242333_0_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null RRAGD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86196 BRD-K97588749 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.83123 kidney BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.46784 Xylem TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.326 r6 part of the basolateral reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54236 TCTN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11735 BRD-A49172652_lansoprazole_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SET-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.00656 CRCGN010_HEPG2_24H:E11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.28422 DUSP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49197 BRD-K28820796 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.19765 BRD-K19731191 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.89264 BRD-K30625175 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36659 GTEX-S33H-1626-SM-4AD68 GTEx Tissue Sample Gene Expression Profiles 1.0 1.78577 HSDL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56883 H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-L9-A443-01A-12R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ifenprodil-5044 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5451-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SLC35F5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29728 FAM98C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96323 H3K27me3_CD14-positive monocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellum_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.40201 Cuneate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32777 NCI-H2196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.465 Protein body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.272 PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QDT8-1326-SM-48TYY GTEx Tissue Sample Gene Expression Profiles 1.0 1.05656 aklomide LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45566 GSE237040_4_v_5_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Fetal Kidney Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -0.941875 zinc ion binding GO Molecular Function Annotations 2023 1.0 null amino-acid betaine metabolic process GO Biological Process Annotations 2025 1.0 null GTEX-P78B-1326-SM-3P611 GTEx Tissue Sample Gene Expression Profiles 1.0 2.43455 choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 3.23074 Hepatobiliary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.034 Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A97G-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-A75P-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K90360779 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10534 LOUNH91 CCLE Cell Line Gene CNV Profiles 1.0 1.43124 GTEX-XBEW-1526-SM-4AT4K GTEx Tissue Sample Gene Expression Profiles 1.0 1.16042 GSE211286_4_v_6_tcf12_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K76450447 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.27998 BRD-K50168500_canertinib_HCC515_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H2126 COSMIC Cell Line Gene Mutation Profiles 1.0 null primary auditory cortex (core)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.46429 CRCGN015_MCF10A_48H:A14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.67006 Proteinuria CTD Gene-Disease Associations 1.0 1.173 posteroventral (inferior) parietal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.26833 GTEX-T8EM-0626-SM-4DM62 GTEx Tissue Sample Gene Expression Profiles 1.0 1.26173 NCIH2196 CCLE Cell Line Gene CNV Profiles -1.0 -1.34863 betaine-homocysteine S-methyltransferase activity GO Molecular Function Annotations 2025 1.0 null inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09621 GSE163862_0_v_3_cisplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-O5YT-0007-SM-32PK7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52515 procainamide-5663 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.990788 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5882-11A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE112762,GSE112767_1_v_3_dgcr8_mouse RummaGEO Gene Perturbation Signatures 1.0 null organic substance biosynthetic process GO Biological Process Annotations 2015 1.0 null GSE216413_1_v_0_gata3_human RummaGEO Gene Perturbation Signatures -1.0 null hippocampus (hippocampal formation)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.67746 Lower epidermis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.761 hypersensitivity reaction disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.050948 PDLIM4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00603176 BRD-K06408981 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.72969 without GeneRIF Biological Term Annotations 1.0 null Large_Intestine-gut endothelial cell Tabula Sapiens Gene-Cell Associations 1.0 -0.10795 Orofacial cleft DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.024 PMC4531812-13058_2015_618_MOESM11_ESM.xlsx-TCGA_Sparse_KM-TFAP2B_TFAP2B Rummagene Transcription Factor Associations 2026 1.0 null intermediate stratum of r6BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.53981 SNU1214 CCLE Cell Line Gene CNV Profiles -1.0 -1.98461 GSE200352_10_v_6_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null Toenail selenium levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.6 POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XYKS-0005-SM-4BRUD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01014 BRD-K42769174 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68497 DGAT2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00738945 SOAT2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0063288 GSE226249_0_v_6_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null frontal pole, left, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.40007 GSE237040_6_v_5_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-R53T-1626-SM-3GAEW GTEx Tissue Sample Gene Expression Profiles 1.0 1.0522 Hepatomegaly CTD Gene-Disease Associations 1.0 1.6491 AKT1_activemutant_216_GSE9484 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -3.67979 inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.951202 POU2F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.4505 primary visual cortex (striate cortex, area V1/17)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.97718 GTEX-WEY5-1126-SM-4LMIE GTEx Tissue Sample Gene Expression Profiles 1.0 0.860943 Urinary tract TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Liver BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.55362 BRD-K85441584 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59034 TMEM179B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0433 NCR3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00498779 BRD-K79568363 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13041 SMAD4-21799915-A2780-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Renal medulla TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.664 Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.87858 MHH-PREB-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Genetic Predisposition to Disease HuGE Navigator Gene-Phenotype Associations 1.0 null GSE240386,GSE242143_8_v_6_morc2_human RummaGEO Gene Perturbation Signatures 1.0 null Tooth Abnormalities HuGE Navigator Gene-Phenotype Associations 1.0 null hsa-miR-4762-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.945471 BRD-K62957665 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0099 arcuate nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.11122 BCL11B_KO_GDS3178_296_mouse_striatum GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1793 GDSC Cell Line Gene Expression Profiles 1.0 1.61857 ATP2A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00532143 A172 BioGPS Cell Line Gene Expression Profiles -1.0 -0.964043 496100500_PCx_probable Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.35283 Perturb_15802_KD_METTL3_SRP373116 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 HS695T DepMap CRISPR Gene Dependency 1.0 3.85365 GSE200673,GSE200691_2_v_5_hmga2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE182680,GSE182683_7_v_13_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null Homocystinuria DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.195 PMC8561673-NIHMS1742950-supplement-Table_S7.xlsx-Housekeeping_MYC_ProxTubGenes-Proximal_Tubule_Enriched_Genes_MYC Rummagene Transcription Factor Associations 2026 1.0 null SMAD4-21799915-A2780-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FOXO4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.23 GSE149760_3_v_1_elof1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE158197_2_v_10_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null Intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.007 PMC4740183__F3 PFOCR Pathway Figure Associations 2024 1.0 null diseases GeneRIF Biological Term Annotations 1.0 null dorsal motor nucleus of the vagus (vagal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.60831 s-methylmethionine-homocysteine s-methyltransferase activity GO Molecular Function Annotations 2015 1.0 null S-methylmethionine-homocysteine S-methyltransferase activity GO Molecular Function Annotations 2023 1.0 null gastrointestinal tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05336 GTEX-XUYS-0226-SM-47JX1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.95874 VMRCRCW CCLE Cell Line Gene Expression Profiles 1.0 1.5988 aortic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.143485 BRD-K37262603 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45113 Crus 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12034 H3K27me3_megakaryocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uvula (IX), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38917 BRD-K76942055 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26325 s-adenosylmethionine-dependent methyltransferase activity GO Molecular Function Annotations 2015 1.0 null GTEX-XAJ8-0226-SM-4GIB2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.968827 LPAR5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00534182 cytosol GO Cellular Component Annotations 2015 1.0 null KYSE30 CCLE Cell Line Gene Expression Profiles -1.0 -2.02818 inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.970258 9857_WEE1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 3.31619 BRD-K90934902 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06216 SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.91372 GTEX-XBED-0926-SM-48TCE GTEx Tissue Sample Gene Expression Profiles 1.0 1.31059 Cleft Lip With Or Without Cleft Palate DisGeNET Gene-Disease Associations 1.0 null BRD-K61388138 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.3945 Medullary reticular nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26306 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20Q-11A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.04272 H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE62843,GSE64370_0_v_3_furan_mouse RummaGEO Drug Perturbation Signatures 1.0 null PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R45C-0006-SM-3GAD6 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 SNU840 DepMap CRISPR Gene Dependency 1.0 4.68502 MYOCD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3963 BRD-K24496482_SB590885_MDAMB231_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5681-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A13122391_16-HYDROXYTRIPTOLIDE_HCC515_24.0_h_0.08_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE173810_4_v_3_igf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null intestinal mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.104458 viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.445653 Pancreas-fibroblast Tabula Sapiens Gene-Cell Associations 1.0 -0.100088 BRD-K74701308 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65151 ketorolac-6489 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K63654001 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50074 GSE226249_0_v_8_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null 451LU COSMIC Cell Line Gene Mutation Profiles 1.0 null SCCPDH LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00955094 Thymus BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.45492 BRD-A27887842_PREDNISOLONE_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055116 primary auditory cortex (core)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.3058 TBX5 ChEA Transcription Factor Targets 1.0 null NCIH1581 CCLE Cell Line Gene CNV Profiles -1.0 -1.41661 GTEX-T5JW-0005-SM-3GADE GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 FCN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00699181 GSE200673,GSE200691_2_v_3_hmga2_mouse RummaGEO Gene Perturbation Signatures 1.0 null nci-h226br cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.464174 H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR3A_01_139 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.61298 HOXA10 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.9244 parabigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.36908 klf9_17379758_jejunum_lof_mouse_gpl339_gds2703 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.540416 DUSP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19107 H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XQ3S-0006-SM-4BOQ4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.942187 Kidney Chromophobe_KICH_TCGA-KL-8329-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SDK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00492461 Cellulose microfibril COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.838 FPGS LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00425893 Sarcoma_SARC_TCGA-3B-A9HQ-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-548ag TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 PLK3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00629055 PMC8494348-pone.0257161.s002.xlsx-D20-OXT_ext_OXT_ext-NOT_ext-Gene_Name_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUZ12-20075857-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null hsa-miR-5095 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GSE122067_3_v_1_mtch2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XBED-0126-SM-47JY7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.906327 oculomotor nuclear complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.15215 LY-294002-2699 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_MCF10A.TP53.M_24H:B22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5858 CRCGN008_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.4766 BRD-K13094524_PFI-1_HCC515_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Hyperhomocysteinemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.908 GTEX-WFON-2126-SM-3LK7O GTEx Tissue Sample Gene Expression Profiles -1.0 -0.854812 FOXA3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.5255 TAF12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8879 MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null embryonic structure TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053376 BRD-K08417745_SID 26681509_VCAP_6.0_h_88.8_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A7Q1-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null REXO5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70702 GSE146074_9_v_7_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null CD33 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00514695 NCIH82 DepMap CRISPR Gene Dependency 1.0 3.32198 GTEX-VJYA-0005-SM-3P5ZD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.922893 epithelial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053544 Plastid COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.73 GSE193258,GSE193259_5_v_4_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null ERF::FOXO1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.3404 BRD-K35288418 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72195 EXTL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34479 HS578T Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.846878 STX3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00539944 H3K27ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S7SF-1026-SM-4AD4I GTEx Tissue Sample Gene Expression Profiles 1.0 1.22463 ADRA2C LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00733976 PMC7851696__F1 PFOCR Pathway Figure Associations 2024 1.0 null TWF2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00543861 pcyt1a GeneRIF Biological Term Annotations 1.0 null PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_22_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-3591-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 TBP ENCODE Transcription Factor Targets 1.0 null PSIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90579 orbital frontal cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.40073 BRD-K04498687 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30819 Urinary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.037 HCC1500 CCLE Cell Line Gene Expression Profiles -1.0 -1.77569 FGF1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00519268 etamsylate-4576 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null striatum_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.89307 BRD-K18601936 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67664 retina BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.929264 Brain Ischemia HuGE Navigator Gene-Phenotype Associations 1.0 null MMP17 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00680802 periventricular stratum of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.68188 Epithalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3858 genetic GeneRIF Biological Term Annotations 1.0 null PMC8567138-Table_2.xlsx-Sheet1-IGFBP5_AND_IGFBP7_NOT_IGFBP3_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QEL4-1526-SM-447AB GTEx Tissue Sample Gene Expression Profiles 1.0 0.880135 ARHGAP15 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00522296 vomeralnasalorgan.VMO. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.857047 u87 HPA Cell Line Gene Expression Profiles 1.0 1.0924 rostral division of VL Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.969613 H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WEY5-1026-SM-4LMK9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.03197 8416_SRP68_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.03051 BRD-K20470077 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48659 PLA2G2E LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00515022 9600_UPF1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.02841 H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null amygdaloid complex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.03191 BRD-K61247793 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03339 GTEX-VUSG-2426-SM-4KKZG GTEx Tissue Sample Gene Expression Profiles 1.0 0.890379 GSE216538_7_v_2_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null r7 portion of ambiguous motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40272 MYC ENCODE Transcription Factor Targets 1.0 null risk GeneRIF Biological Term Annotations 1.0 null H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K36923996 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.87449 urinary system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.213291 Parasolitary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.11724 Adrenocortical carcinoma_ACC_TCGA-OR-A5L5-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE146074_0_v_3_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null Rumen TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.38 SLR21 CCLE Cell Line Gene Expression Profiles 1.0 2.27568 COASY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11307 H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K72414522_AZD-5438_A549_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CARF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47477 Lung adenocarcinoma_LUAD_TCGA-62-A472-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T5JW-1226-SM-3GACY GTEx Tissue Sample Gene Expression Profiles 1.0 1.61049 BANK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00505082 GSE70499_3_v_2_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K03089783 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.22223 BRD-K12683022 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.40528 KDM5C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29246 hsa-miR-4531 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 PMC4287344-pgen.1004835.s007.xls-exome_sequence_ERF_GWAS-GENE_ERF Rummagene Transcription Factor Associations 2026 1.0 null ARIH2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00384881 BRD-K31377965 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57688 BRD-A01717111 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51242 orofacial clefts GAD Gene-Disease Associations 1.0 null BRD-K48488978_YM-201636_HCC515_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K98720112 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51989 BRD-K87158974 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.629 GPR84 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00703689 GTEX-XPVG-0006-SM-4B65Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22924 Hippocampal formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09248 PFKFB2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00720782 Dimethylglycine HMDB Metabolites of Enzymes 1.0 null BB30-HNC GDSC Cell Line Gene Expression Profiles -1.0 -1.42202 mediodorsal nucleus of thalamus_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10924 GSE182179_2_v_1_kdsr_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-SE5C-0006-SM-4BRW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35659 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.438739 T47D Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.918479 3862_HNRNPDL_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.09601 NUDUL1 CCLE Cell Line Gene CNV Profiles 1.0 3.2803 GTEX-RWS6-0001-SM-3NMAL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03962 GTEX-W5WG-0002-SM-3NMDN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15016 BCL10 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00493771 FOXP3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.4255 MDAMB436 CCLE Cell Line Gene Expression Profiles 1.0 2.11912 EZH2 ENCODE Transcription Factor Targets 1.0 null GSE186005_1_v_2_klf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K08799663 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12149 blood TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056627 hippocampus (hippocampal formation)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.924639 H2AFZ ENCODE Transcription Factor Targets 1.0 null NCI H322M BioGPS Cell Line Gene Expression Profiles 1.0 0.928619 hyperhomocysteinemia GAD Gene-Disease Associations 1.0 null CACNA1S LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00900457 GTEX-QEL4-1226-SM-447A4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.75826 BRD-K95309561_DIENESTROL_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cellular process GO Biological Process Annotations 2015 1.0 null outer SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.14407 GTEX-W5X1-0006-SM-3GIJZ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05306 6851_PSMB3_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.97378 CYYR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.18977 molecular layer of the DG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.73512 BRD-K18768614 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37706 ventromedial hypothalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.10596 AIRE LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00571874 GSE88819_6_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Cleft Lip HuGE Navigator Gene-Phenotype Associations 1.0 null IALM CCLE Cell Line Gene Expression Profiles -1.0 -1.77546 RNF2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 6855_PSMB6_P1 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 3.50651 renal cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.389289 Prostate adenocarcinoma_PRAD_TCGA-HC-7752-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE62843,GSE64371_2_v_5_furan_mouse RummaGEO Drug Perturbation Signatures -1.0 null OVMANA DepMap CRISPR Gene Dependency 1.0 2.59318 PMC8200296-LSA-2020-00928_TableS2.xlsx-table_s2_DEGs_log2foldchange_0-Table_S2_List_of_DEGs_induced_by_YY1_knockdown_YY1 Rummagene Transcription Factor Associations 2026 1.0 null GSE186460_0_v_2_baricitinib_human RummaGEO Drug Perturbation Signatures -1.0 null HMGB1P1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3059 KMRC3 CCLE Cell Line Gene Expression Profiles 1.0 1.77823 GTEX-X4EP-0005-SM-3P5ZE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55176 dorsolateral prefrontal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.17372 zinc ion binding GO Molecular Function Annotations 2015 1.0 null biological_process GO Biological Process Annotations 2015 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-94-7557-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K51654114 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30155 ZNF8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.8056 GTEX-S4P3-0226-SM-3K2BD GTEx Tissue Sample Gene Expression Profiles 1.0 1.09873 vesicle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 BRD-K98731550 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4783 GSE182179_5_v_4_kdsr_human RummaGEO Gene Perturbation Signatures -1.0 null Heart Defects, Congenital HuGE Navigator Gene-Phenotype Associations 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.54907 EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STARD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63437 GP5D COSMIC Cell Line Gene Mutation Profiles 1.0 null Nucleus of the solitary tract, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.6631 GTEX-XMK1-0001-SM-4B64F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12145 C8A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00618183 SOX12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.0971 CORL24 CCLE Cell Line Gene CNV Profiles -1.0 -1.34713 COLO678 DepMap CRISPR Gene Dependency 1.0 2.89519 GSE218879_1_v_2_acetaminophen_mouse RummaGEO Drug Perturbation Signatures -1.0 null amygdaloid complex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.8851 ECC12 CCLE Cell Line Gene Expression Profiles 1.0 1.44703 r8 part of parvocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.65033 GTEX-PLZ6-0226-SM-3P61I GTEx Tissue Sample Gene Expression Profiles 1.0 1.01736 BRD-K60866521_idelalisib_MCF7_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 GTEX-REY6-1426-SM-48FDK GTEx Tissue Sample Gene Expression Profiles 1.0 0.905783 mRNA_TCF3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Middle frontal gyrus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.144 methyltransferase GeneRIF Biological Term Annotations 1.0 null Photosystem COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.526 NFIC::TLX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.625 external cortical nucleus of inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02647 GTEX-SSA3-0002-SM-3P61R GTEx Tissue Sample Gene Expression Profiles -1.0 -0.98543 S-methyltransferase activity GO Molecular Function Annotations 2023 1.0 null variants GeneRIF Biological Term Annotations 1.0 null MDST8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2142 BRD-K12884811 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02165 RCC-FG2 COSMIC Cell Line Gene Mutation Profiles 1.0 null NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.29252 mRNA_SOX9_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null SG in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.75856 NAIF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41121 MAZ ENCODE Transcription Factor Targets 1.0 null BRD-K68086276 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.31511 6854_PSMB6_P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.72522 superficial stratum of Ist Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53638 orbital frontal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.963229 Fumarate reductase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.03 CRCGN012_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.40116 NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.52013 OAW28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.31673 l-1210 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.781063 BRD-K09777330 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 6.15127 H3K4me1_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC5550424-41467_2017_212_MOESM4_ESM.xlsx-Hematlas-Genesets-NANOG_NANOG Rummagene Transcription Factor Associations 2026 1.0 null SNRPB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56577 iPS-20b Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 0.832858 nucleobase-containing compound metabolic process GO Biological Process Annotations 2015 1.0 null GSE234647_1_v_3_regorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN017_MCF10A.TP53.M_24H:F01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.05285 MDAMB468 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.00814 GPRC5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82693 COLO 205 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.852722 Primary somatosensory area, lower limb, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44574 ZNF554 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89233 CTCF_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZN-0226-SM-3DB8D GTEx Tissue Sample Gene Expression Profiles 1.0 1.93741 6841_PSMA1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 5.27923 GTEX-V955-0005-SM-3P5ZC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37595 JHH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17029 H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KM12 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-PWCY-0826-SM-48TCR GTEx Tissue Sample Gene Expression Profiles 1.0 1.39209 QRICH1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00803459 TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AFF3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0053457 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XP-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K24946605 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31324 kidney HPA Tissue Gene Expression Profiles 1.0 1.53073 BRD-K32582260 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21568 Prostate adenocarcinoma_PRAD_TCGA-EJ-7781-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Mesophyll TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.8 Nucleus of the lateral lemniscus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03554 GSE167546_1_v_2_atrx_human RummaGEO Gene Perturbation Signatures -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Q-11A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE193282_3_v_1_cd44_mouse RummaGEO Gene Perturbation Signatures 1.0 null SOX8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.4436 amygdaloid complex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.20054 CSF3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00486592 GSE237040_4_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kidney Chromophobe_KICH_TCGA-KL-8332-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dentate (lateral) nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.26202 ELAVL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.97737 BRD-K69396470 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28089 GTEX-N7MS-0011-R11A-SM-2HMJS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.903041 GSE228619_0_v_1_cdh11_human RummaGEO Gene Perturbation Signatures 1.0 null SHISA2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00614751 KIAA0319L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87175 GTEX-R55C-0626-SM-2TF4Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.917727 ABCC2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00578083 H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PDCD2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46465 H3K4me3_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K70302892 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39212 GTEX-RM2N-0006-SM-2TF5H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16094 GSE237040_2_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null layer 6 of PrS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.52835 lateral habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.00146 MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_megakaryocyte_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SSA3-0005-SM-32QOT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27846 arcuate nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.29704 X, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.99439 extracellular region COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Lung adenocarcinoma_LUAD_TCGA-50-5066-02A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior cortical nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.18951 extracellular vesicular exosome COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Stele TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.481 CRCGN015_HEPG2_48H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.26289 BRD-K37584517 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55229 RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r9 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08064 GTEX-XUJ4-0926-SM-4BOPA GTEx Tissue Sample Gene Expression Profiles 1.0 1.47905 paraventricular nucleus, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.67506 substantia nigra, reticular part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09632 Kidney BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 2.2603 oxybenzone-5410 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.402 GATA3-21867929-TH1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null excretory gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NOMO1 Achilles Cell Line Gene Essentiality Profiles 1.0 1.43772 CRCGN015_MCF10A.TP53.M_24H:O07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.3018 SG in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.947418 H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 8078_SLC39A7_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.09887 Celiac Disease HuGE Navigator Gene-Phenotype Associations 1.0 null GTEX-XQ8I-1626-SM-4BOOI GTEx Tissue Sample Gene Expression Profiles 1.0 1.21578 NUTM2A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0092986 Lung squamous cell carcinoma_LUSC_TCGA-33-6737-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hsa-miR-3116 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 2-aminobenzenesulfonamide-3063 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-QDVN-0006-SM-48U1R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1332 Prostate adenocarcinoma_PRAD_TCGA-VN-A88I-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null endometriosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.230063 betainehomocysteine GeneRIF Biological Term Annotations 1.0 null GTEX-U4B1-1226-SM-4DXT7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05624 lateral preoptic nucleus, PO2 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01436 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7920-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEP57 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12064 TMEM47 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14844 GTEX-SNMC-0006-SM-2XCFE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.986454 GNRH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79704 BRD-K54330070_-666_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null midbrain reticular formation, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.843473 GTEX-WFJO-0426-SM-4LVM7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.892459 GSE158197_6_v_3_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4817-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null diencephalon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.085545 neural plate TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.181494 KP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.893964 H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LDB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52993 BRD-A60571864_BUDESONIDE_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K94442101 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.56353 496100580_PCx_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.03566 BRD-K39672303 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24612 BRD-K04680784 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15072 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5696-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LYSMD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50086 loracarbef-3532 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-8674-01A-21R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null chr5_79070503_T_G_b38 GTEx eQTL 2025 1.0 1.89258 mRNA_GATA3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null cellular biosynthetic process GO Biological Process Annotations 2015 1.0 null Dentate gyrus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4274 SW 1417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.966364 mRNA_ETV3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BRD-A04618830 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.42735 GTEX-XLM4-0005-SM-4AT4P GTEx Tissue Sample Gene Expression Profiles -1.0 -0.888813 urinary tract TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE216043_11_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.031702 ZNF541 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39605 ChIP_K27me3_17603471_mouseMEF ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null XPO5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06451 r9 part of parvocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.18649 GSE200352_9_v_6_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null ASNS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11926 GTEX-P4QR-0006-SM-2I5GN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33226 FCRL4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00631487 PIK3C3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00472737 CD300LD LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00648435 characterized GeneRIF Biological Term Annotations 1.0 null Mucilage TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.001 GTEX-P4QS-1126-SM-3NMD5 GTEx Tissue Sample Gene Expression Profiles 1.0 2.01036 excretory gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060198 CRCGN016_MCF10A.WT.HP_24H:P07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.10095 GTEX-UPIC-0926-SM-4IHLV GTEx Tissue Sample Gene Expression Profiles 1.0 2.63226 SW 1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.37245 CHD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41985 coenzyme metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-XBEC-1526-SM-4AT68 GTEx Tissue Sample Gene Expression Profiles 1.0 2.14756 methyltransferase activity GO Molecular Function Annotations 2015 1.0 null GSE223893_2_v_9_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null non-small cell lung cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.088153 CRCGN016_MCF10A.WT.HP_24H:E20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.37318 epistatic GeneRIF Biological Term Annotations 1.0 null HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.06696 Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.535 purine nucleoside metabolic process GO Biological Process Annotations 2015 1.0 null MAP2K1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00652224 SELENON CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60743 embryoday6.5 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.23083 connective tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052682 POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PPP1R15A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37268 SK-UT-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Endocrine gland cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.049 BRD-K70428675 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.15451 496100458_FWM_no dementia_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.26424 MAX_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null XBP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.4713 estradiol_homo sapiens_gpl570_gds3283 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null kidney_c HPA Tissue Sample Gene Expression Profiles 1.0 1.17661 Field CA3, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11374 GSE127790_13_v_3_zcchc8_mouse RummaGEO Gene Perturbation Signatures -1.0 null 496100494_HIP_no dementia_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.09118 GSE146074_1_v_8_ly6e_mouse RummaGEO Gene Perturbation Signatures 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5J2-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GADD45GIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35177 liver BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 H3K27ac_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null FXYD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98208 BRD-K48308783 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69536 ZBTB7A ENCODE Transcription Factor Targets 1.0 null H3K4me3_Colon Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Diabetes Mellitus, Type 2 HuGE Navigator Gene-Phenotype Associations 1.0 null PMC7220941-41598_2020_64431_MOESM2_ESM.xlsx-WS2_2019_Affy_IDs_SignalsQN-Unnamed_2_MITF Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OHPM-2626-SM-33HC5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.851 III, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.852673 mRNA_EOMES_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTEX-S95S-1626-SM-2XCDJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.880282 CP in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.46957 KMRC20 CCLE Cell Line Gene Expression Profiles 1.0 2.15831 Dentate gyrus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.35022 10029_ZC3H8_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.51073 hsa-miR-3198 TargetScan Predicted Conserved microRNA Targets 1.0 1.11641 4805_MAP2K7_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.42084 PHF21A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82669 superficial stratum of CA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07242 Popliteal pterygium syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.445 Perturb_8071_KD_SFPQ_SRP281189 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 BRD-K45928581 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.01651 3214_FTSJ3_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 3.05004 Brain Lower Grade Glioma_LGG_TCGA-HT-7691-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FBP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00580975 BRD-K02844551 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27116 BRD-K32018176 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37579 BRD-K57786075 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25193 hsa-miR-4715-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.49 H3K4me1_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SPAG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46281 purine-containing compound metabolic process GO Biological Process Annotations 2015 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3BZ-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K75626008 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04654 GTEX-PX3G-0226-SM-3NB2C GTEx Tissue Sample Gene Expression Profiles 1.0 0.967845 GSE224877_2_v_1_pctp_mouse RummaGEO Gene Perturbation Signatures 1.0 null Huntington's Disease_CNS - Brain - Striatum (MMHCC)_GSE7958 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.73745 mRNA_NR5A2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null PMC12670081-mct-24-0704_supplementary_table_s10_suppst10.xlsx-Supplementary_Table_S10-Supplementary_Table_S10_Differential_expression_of_TFCP2-rearranged_RMS_Vs_Other_RMS_FC_3_padj_0_01_TFCP2 Rummagene Transcription Factor Associations 2026 1.0 null POU3F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.4449 Dentate gyrus, granule cell layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27683 BIRC3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00802508 ZNF449 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99048 PCED1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70995 Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FO-11A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r8 portion of ambiguous motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07621 PMC10243915-uxad037_suppl_supplementary_table_s1b-table_s3b.pdf-463-RAG1_RAG1 Rummagene Transcription Factor Associations 2026 1.0 null transferase activity GO Molecular Function Annotations 2015 1.0 null GTEX-OXRK-1426-SM-3NB19 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20308 ZNF20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7403 ZNF664 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47219 GTEX-POMQ-0126-SM-48TD6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.899142 KMS-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.928783 DOHH-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null 496100535_FWM_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.03248 placenta_3a HPA Tissue Sample Gene Expression Profiles -1.0 -1.27146 GSE86507,GSE86509_0_v_8_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17547 HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.985017 496100497_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.69436 GTEX-QMRM-0926-SM-447BR GTEx Tissue Sample Gene Expression Profiles 1.0 1.14728 Glutathione hydrolase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.535 BRD-K31372389 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53683 GTEX-U3ZN-0006-SM-3DB7Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07349 intermediate stratum of m2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.93228 STX4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00766452 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RP-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN010_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.29792 catalytic activity GO Molecular Function Annotations 2015 1.0 null Storage tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.588 IZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.838309 CAL-54 GDSC Cell Line Gene Expression Profiles 1.0 1.54671 BRD-K13849122 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.24309 SW 837 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.53125 Hypertrophy CTD Gene-Disease Associations 1.0 1.56312 VNN2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00531701 GSE240386,GSE242143_1_v_4_morc2_human RummaGEO Gene Perturbation Signatures 1.0 null ARX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24474 BRD-K83751422 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.64769 TSKU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03604 GSE208350_0_v_1_fgfr1_human RummaGEO Gene Perturbation Signatures -1.0 null Betaine-homocysteine S-methyltransferase, BHMT InterPro Predicted Protein Domain Annotations 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A0YN-11A-11R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.970366 Liver Neoplasms CTD Gene-Disease Associations 1.0 1.49864 betaine-homocysteine S-methyltransferase activity GO Molecular Function Annotations 2023 1.0 null BRD-K79090631_CGP-60474_HCC515_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null blood cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058266 GTEX-WFG7-0005-SM-3GIKM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36126 BRD-K19220233_JNK-9L_PC3_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KIF1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96801 LS-411N COSMIC Cell Line Gene Mutation Profiles 1.0 null medial portion of STH Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.871649 single-organism biosynthetic process GO Biological Process Annotations 2015 1.0 null Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.094 TFDP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59695 FOXS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.3636 SPHK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99853 mRNA_DLX3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BRD-K19220233_JNK-9L_HME1_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TCF12 ENCODE Transcription Factor Targets 1.0 null GTEX-S33H-1126-SM-2XCB6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.10317 KCNH7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00638501 GSE216757_4_v_1_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K45984211 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3099 hsa-miR-3653 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 BRD-K51363316 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.0597 BRD-K38980456 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0254 BRD-K03812127 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22732 PMC5058748-oncotarget-07-31177-s002.xlsx-ZNF224_gene_peaks_promoter-Table_S3_Genes_that_contain_a_ZNF224_enriched_region_within_1_kb_of_the_transcription_ZNF224 Rummagene Transcription Factor Associations 2026 1.0 null LRRC25 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00593737 head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053915 CTSZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68006 ZNF563 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82976 liminal reticular formation of m2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.12714 GTEX-SIU7-1326-SM-4BRWW GTEx Tissue Sample Gene Expression Profiles 1.0 1.18858 BRD-K76738405 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36805 GTEX-NL4W-0006-SM-2I3GH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.939241 GTEX-R55C-0726-SM-48FCN GTEx Tissue Sample Gene Expression Profiles 1.0 1.28507 CRCGN017_MCF10A.TP53.M_24H:E01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.12885 mantle zone of r11Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06194 BRD-K49742819 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13312 BRD-K52123365 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.74263 hsa-miR-3920 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GYS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81237 BRD-K11844807 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49469 nucleobase-containing small molecule metabolic process GO Biological Process Annotations 2015 1.0 null palate TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.67984 MEX3B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0062487 6850_PSMB2_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 3.41337 GTEX-UPJH-0006-SM-3GACW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24575 caused GeneRIF Biological Term Annotations 1.0 null Dimethylglycine dehydrogenase deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.306 496100388_HIP_probable Alzheimer's disease_no TBI_87_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.40015 BRD-U61997977_WZ-4-145_SKBR3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TMEM167A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56988 methionine metabolic process GO Biological Process Annotations 2015 1.0 null G6PC3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00655504 BAG3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00366944 Lung adenocarcinoma_LUAD_TCGA-69-8253-01A-11R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Putrescine HMDB Metabolites of Enzymes 1.0 null CXCL9 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00633539 BRD-K87000197 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.04879 PMC8533474__F5 PFOCR Pathway Figure Associations 2024 1.0 null GTEX-VJYA-0126-SM-4KL1P GTEx Tissue Sample Gene Expression Profiles -1.0 -0.890198 U138MG CCLE Cell Line Gene CNV Profiles -1.0 -2.27466 BRD-K47366416 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67827 Seedpod TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.521 Secondary motor area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.90912 GTEX-U3ZH-0005-SM-3DB72 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02661 COLO 201 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.965458 GSE154577_13_v_10_plagl1_human RummaGEO Gene Perturbation Signatures 1.0 null MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null olfactorybulb BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.887303 FOXA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.6577 STAT3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.7379 BRD-K00877314 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17381 Gli1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.5154 hsa-miR-4296 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 Anterior hypothalamic nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17889 external part of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19837 lung cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057596 TFAP2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 160.275 lateral habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.54804 TCF12_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K20437312 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.9059 cefadroxil-4161 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KLRC4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00503303 blast cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065153 BRD-K94862255 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12195 SKRC31 CCLE Cell Line Gene Expression Profiles 1.0 3.40837 PMC5687749-pone.0188272.s005.xlsx-Supplementary_Table_3-Supplementary_Table_3_Differentially_Expressed_Genes_in_Common_between_AFX_compared_to_both_Keratinocytes_and_Fibroblasts_FOXO4 Rummagene Transcription Factor Associations 2026 1.0 null nci-h226 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.199576 GSE248883_0_v_1_shmt2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE100863,GSE100864_2_v_1_tet2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE135350_2_v_4_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney Chromophobe_KICH_TCGA-KL-8339-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25U-01A-11R-A16W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Seed coat TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.085 BRD-K75588273 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.96763 GTEX-X638-0005-SM-47JX6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14343 BRD-K79090631_CGP-60474_BT20_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null kasugamycin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07501 BRD-K34797601 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34582 GSE188458_2_v_3_hydrogen peroxide_human RummaGEO Drug Perturbation Signatures 1.0 null striatum_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.4393 H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HL-60 GDSC Cell Line Gene Expression Profiles -1.0 -1.4862 BRD-K37328981 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.24952 TTLL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03314 VPREB1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00624795 VDR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73972 Uterine Carcinosarcoma_UCS_TCGA-NA-A4QX-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder-endothelial cell of lymphatic vessel Tabula Sapiens Gene-Cell Associations 1.0 -0.107235 GSE144443_5_v_1_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null BRD-K97761115 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21556 NRAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01107 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4619-11A-01R-1758-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WNT9B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00565411 Disease of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.022 GTEX-VJYA-1326-SM-3GIJC GTEx Tissue Sample Gene Expression Profiles 1.0 1.23681 RBBP5 ENCODE Transcription Factor Targets 1.0 null BRD-K67873600 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.15069 GTEX-XXEK-0005-SM-4BRWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52091 FCRLA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00744853 ARID3A ENCODE Transcription Factor Targets 1.0 null CRCGN017_MCF10A.WT.HP_24H:P12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2997 GSE63048_11_v_12_morc1_mouse RummaGEO Gene Perturbation Signatures 1.0 null dorsomedial hypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.990692 CCN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04704 BRD-K47673408 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54896 Endocrine gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GSE183251_4_v_6_cyp2c70_mouse RummaGEO Gene Perturbation Signatures 1.0 null MAP2K4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69408 Six4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.1137 GTEX-R53T-1026-SM-48FCO GTEx Tissue Sample Gene Expression Profiles 1.0 1.15626 Inflammatory and toxic neuropathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.138 VSIG10 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00620568 BRD-K30220159 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47838 BRD-K64517075_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MBNL2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00667239 GSE148263_6_v_9_trim3_human RummaGEO Gene Perturbation Signatures -1.0 null STAT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.2243 GTEX-RTLS-1326-SM-46MUN GTEx Tissue Sample Gene Expression Profiles 1.0 2.27249 BRD-K44244207 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.208 POLR1B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00684226 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.909557 all GWASdb SNP-Phenotype Associations 1.0 0.031645 BRD-K57382977 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.33247 BRD-K50008138 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.07287 Cortical amygdalar area, posterior part, lateral zone, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66741 H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-A15086915 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.08244 TPGS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13199 BACH1-22875853-CHIP-PCR-HELA-AND-SCP4-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE127790_4_v_3_zcchc8_mouse RummaGEO Gene Perturbation Signatures -1.0 null hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01021 H3K27me3_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRCGN015_HEPG2_48H:I10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.53998 786-O Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.51926 cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.217693 Lung squamous cell carcinoma_LUSC_TCGA-39-5011-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE234340_4_v_7_muc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Radicle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.548 STAT3 ENCODE Transcription Factor Targets 1.0 null bendroflumethiazide-2555 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null single-organism process GO Biological Process Annotations 2015 1.0 null GSE238116_1_v_0_egr1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-W5WG-2726-SM-4LMIC GTEx Tissue Sample Gene Expression Profiles 1.0 1.0802 GSE246053_1_v_2_hnf4a_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC10809641-DataSheet3.pdf-34-BHLHE41_BHLHE41 Rummagene Transcription Factor Associations 2026 1.0 null MBOAT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72352 8873_THAP1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.63749 r10 part of ventral parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00999 periventricular stratum of r8Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.60509 pancreas GTEx Tissue Gene Expression Profiles -1.0 -0.839319 GTEX-WFJO-0226-SM-3GIKW GTEx Tissue Sample Gene Expression Profiles 1.0 0.979334 PMC3044438__F3 PFOCR Pathway Figure Associations 2023 1.0 null ZNF628 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40601 ADNP_Deficiency - NULL MUTATION_GDS2540_692_mouse_E9 embryos - Homozygous mutant GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.795701 TNFRSF12A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00481965 hsa-miR-3928 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GSE193249_0_v_1_gpx8_human RummaGEO Gene Perturbation Signatures -1.0 null methionine biosynthetic process GO Biological Process Annotations 2015 1.0 null RBFOX2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00404428 atopic dermatitis GWASdb SNP-Phenotype Associations 1.0 0.55536 hematopoietic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057177 STPG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29764 PMC6606599-41598_2019_45777_MOESM14_ESM.xlsx-SAVA_DE_genes_promoter_DMRs-Unnamed_29_TBXT Rummagene Transcription Factor Associations 2026 1.0 null mRNA_EP400_22196727 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null nucleoside metabolic process GO Biological Process Annotations 2015 1.0 null Anteroventral preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24162 nucleus of the inferior collicular brachium, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42038 digestive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 Perturb_8705_KD_SIRT1_SRP267968 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.40123 H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-A57762296 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20761 GTEX-SUCS-1126-SM-4DM61 GTEx Tissue Sample Gene Expression Profiles 1.0 0.915028 Spinal Dysraphism HuGE Navigator Gene-Phenotype Associations 1.0 null callosal sling Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05819 TNFRSF10B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00677979 BCAS1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00763845 GTEX-U3ZN-0002-SM-3NMDF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12696 FERMT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00891651 NFYA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.6804 eticlopride-5695 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8434-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN011_HEPG2_24H:E10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1532 H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null KBTBD2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00700022 trichostatin A-3058 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Inferior temporal gyrus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.254 PLPP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73913 BRD-K78431006_crizotinib_MCF10A_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-U51951544_-666_PHH_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A20213616 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.70336 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81I-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QMRM-0005-SM-3NB2A GTEx Tissue Sample Gene Expression Profiles -1.0 -0.993751 GTEX-WFG8-0001-SM-4LVN8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36979 disease GWASdb SNP-Disease Associations 1.0 0.029735 GTEX-WFON-0926-SM-4LVMK GTEx Tissue Sample Gene Expression Profiles 1.0 1.0459 HOXC12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38131 Lung adenocarcinoma_LUAD_TCGA-NJ-A55R-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K11641139 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.38532 GTEX-U3ZN-0326-SM-3DB86 GTEx Tissue Sample Gene Expression Profiles 1.0 0.852041 GTEX-R55D-1226-SM-48FE9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.49376 PLEKHJ1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00358276 H3K4me1_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Hepatocellular carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.044 locus ceruleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.78083 inferior olive, principal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1314 H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-A03940741 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19737 PMC6826333__F1 PFOCR Pathway Figure Associations 2024 1.0 null organelle GO Cellular Component Annotations 2015 1.0 null hematopoietic cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064499 6857_PSMC1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.85192 AKT1_knockout_211_GSE39699 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.35436 BRD-K91225366 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47341 HDC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00710881 BRD-K92132228 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08738 GSE255432_4_v_3_imeglimin_mouse RummaGEO Drug Perturbation Signatures 1.0 null TFAP2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 155.967 HT-115 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K40765512 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06008 PMC8410083-elife-65574-fig7-data1.xlsx-KLF10_network-Genes_bound_by_KLF10_in_their_-10_1kb_region_or_differentially_expressed_in_WT_vs_HepKO_hepatocytes_challenged_with_high_sugar_KLF10 Rummagene Transcription Factor Associations 2026 1.0 null subparafascicular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.83187 H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE226770_1_v_0_atrx_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-S7SF-0006-SM-3K2B6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.972233 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4969-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K11671824 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.34513 Glyoxysome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.189 BRD-K47237224 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.595 GSE200673,GSE200691_1_v_5_hmga2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-QDVN-1626-SM-48TZC GTEx Tissue Sample Gene Expression Profiles 1.0 2.02537 hsa-miR-4726-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 CYSRT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53232 GTEX-V955-0004-SM-3NMDH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70166 STK17A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86404 Brain Lower Grade Glioma_LGG_TCGA-P5-A5F6-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K42797038 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65641 GTEX-XBEW-0002-SM-4AT5O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23227 hsa-miR-1287 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null IX, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.30751 SR-786 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.3785 primary auditory cortex (core)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.33679 Fatty acid beta-oxidation multienzyme complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.031 GSE125007,GSE125008_4_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null 6867_PSMD13_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.40651 GTEX-WVLH-0011-R11A-SM-3MJFO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.845977 Excretory gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GTEX-XUW1-1526-SM-4BOOY GTEx Tissue Sample Gene Expression Profiles 1.0 1.25782 Golgi lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.58 GTEX-PX3G-0926-SM-48U12 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.886217 GTEX-R55C-0005-SM-3GAE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12006 H3K4me3_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Coronary Heart Disease DisGeNET Gene-Disease Associations 1.0 null orofacial cleft DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.24211 heart defects, congenital; spinal dysraphism GAD Gene-Disease Associations 1.0 null RIOK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00644065 BRD-A20968261_-666_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null abducens nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.952477 HCC2998 COSMIC Cell Line Gene Mutation Profiles 1.0 null lymphocytic leukemia cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.223662 H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K30727702 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08179 RNF31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.09561 CCL7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00457476 H3K27me3_Breast vHMEC Roadmap Epigenomics Histone Modification Site Profiles 1.0 null reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.043478 CRYZ LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00609408 Kidney renal papillary cell carcinoma_KIRP_TCGA-4A-A93X-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_2day-MOI-10^4_None_GSE44441 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.52701 BT-549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.852722 Crus II, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.86423 BRD-K88551539_10012682_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null midbrain reticular formation, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06657 endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.381755 MAFF ENCODE Transcription Factor Targets 1.0 null ZFP281-18757296-E14-MOUSE ChEA Transcription Factor Targets 2022 1.0 null tiaprofenic acid-4091 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null gata4_18812176_jejunum_tissue_lof_mouse_gpl1261_gds3486 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.158909 Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 kidney_b HPA Tissue Sample Gene Expression Profiles 1.0 1.5725 PMC6344081-elife-40364-supp8.xlsx-PLZF-kd_2d_Diff_Vs_Ctrl_2d-diff-Symbol_ZBTB16 Rummagene Transcription Factor Associations 2026 1.0 null s-methylmethionine metabolic process GO Biological Process Annotations 2015 1.0 null ALDH3B2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00561196 GNAI2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00550232 SKLU1 CCLE Cell Line Gene CNV Profiles -1.0 -1.78595 Pancreatic adenocarcinoma_PAAD_TCGA-IB-7897-01A-21R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12328 H3K4me1_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null pravastatin-lactone LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.79343 GSE162967_0_v_6_fgf21_mouse RummaGEO Gene Perturbation Signatures -1.0 null striatum_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.55973 Anteromedial visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38861 GTEX-PLZ6-0126-SM-48TC6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.884977 BRD-K26233698 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45137 COV318 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.82652 H3K4me1_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CAKI1 BioGPS Cell Line Gene Expression Profiles 1.0 2.41625 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EL-11A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null aortic aneurysm, abdominal; GAD Gene-Disease Associations 1.0 null POLR2A ENCODE Transcription Factor Targets 1.0 null HCC827 Achilles Cell Line Gene Essentiality Profiles 1.0 1.02562 primary auditory cortex (core)_25 pcw_F_12948 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.909389 SCMCRM2 DepMap CRISPR Gene Dependency 1.0 2.42785 cation binding GO Molecular Function Annotations 2015 1.0 null DLAT LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00786432 Lung adenocarcinoma_LUAD_TCGA-49-4506-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OIZI-0226-SM-2XCEE GTEx Tissue Sample Gene Expression Profiles 1.0 0.85925 immune system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.04232 urinary tract TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 SIGLEC7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00610569 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A57G-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Mouth disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.319 BRD-K04853698_LDN-193189_BT20_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4174-01A-02R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null olfactory tubercle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05709 cerebrovascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.406798 Lung-endothelial cell of lymphatic vessel Tabula Sapiens Gene-Cell Associations 1.0 -0.106878 spleen_3d HPA Tissue Sample Gene Expression Profiles -1.0 -0.910935 FGF14 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00736708 CRCGN011_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.5191 primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.36625 6870_PSMD2_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.37985 Nucleus of the solitary tract Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21803 18310505-TableS8 GeneSigDB Published Gene Signatures 1.0 null GTEX-TKQ2-0006-SM-33HBH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14958 Head and Neck squamous cell carcinoma_HNSC_TCGA-WA-A7GZ-11A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OS-RC-2 GDSC Cell Line Gene Expression Profiles 1.0 1.92313 inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.43126 Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A0YR-11A-13R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null viscus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-S4Q7-0006-SM-3K2AT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22931 GTEX-RUSQ-2026-SM-4GIAK GTEx Tissue Sample Gene Expression Profiles 1.0 0.938345 NPEPPS LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00671829 VIIIA Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.956336 H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K02625776 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61896 Spongiome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.062 CRCGN015_MCF10A.TP53.M_24H:F17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3509 extracellular vesicle GO Cellular Component Annotations 2015 1.0 null BRD-K44525591 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4745 H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-A39996500_radicicol_SKBR3_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K08408085 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.23718 GTEX-VUSG-1026-SM-4KKZN GTEx Tissue Sample Gene Expression Profiles 1.0 1.10905 EBF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92505 H3K27me3_mononuclear cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1 ENCODE Transcription Factor Targets 1.0 null HCC1897 CCLE Cell Line Gene CNV Profiles -1.0 -1.37033 level GeneRIF Biological Term Annotations 1.0 null BRD-K71514806 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.367 SPRYD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11959 H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_4464_KO_Bicc1_SRP043577 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.99697 COQ7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.96846 BRD-K06157545 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75548