association	dataset	threshold value	standardized value
PMC8185471-mmc6.xlsx-up-_and_downregulated_genes-Day_6_SOX15-_-_upregulated_and_downregulated_genes_nearby_shared_FO_and_FC_regions_respectively_Related_to_Figure_6_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.112
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.634153
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.7005
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Lipid storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.28245
FTO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49873
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.1524
PIGU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47659
LHFPL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12934
AC-28-RT00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.742805
496100399_PCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.42369
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.003
496100392_HIP_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.41421
PMC9013128-NIHMS1795992-supplement-6.xlsx-ARID2_MUT_Dowregulated-Gene_name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
MSMO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36099
CTCF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23693
COIL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22744
GSE145476_2_v_0_hopx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RPS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12909
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148066,GSE157787_9_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UE-58-EW15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297258
MACO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24527
PGAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76318
GE-40-GQ38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241244
GSE217378_2_v_0_lin28b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.748753
GSE104508_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ALAD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.41751
GSE103309_2_v_0_ube3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZD-85-ND87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.329356
SLC26A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18956
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.289
NCAPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05435
GSE157594_5_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-09-EA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.589473
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2674
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.205
CEP76	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53425
GSE164463_0_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Myocardial infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.351
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.33882
HPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34066
ZNF740	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	139.323
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Up_bins-Up_bins_gaining_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
AE-13-CX28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.4195
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MEGF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36435
GSE125014_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
YAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5319
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.484712
GSE224969,GSE224971_3_v_5_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VD-88-MW70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.319983
GSE210655_3_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252162
DF-00-DK69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.865969
GSE255432_7_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Bach1::Mafk	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.0877
PMC11462941-CAS-115-2947-s001.pdf-240-ZFX_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.301698
PMC12179083-Table_6.xlsx-VCF_Variants_Master_File-Gene_symbol_TBX1	Rummagene Transcription Factor Associations 2026	1.0	null
MUTYH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2402
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.7616
GSE148692,GSE148695_5_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6962646-mmc2.xlsx-StemCell_Genesets_2018-PITX2_PITX2	Rummagene Transcription Factor Associations 2026	1.0	null
SLC20A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22807
IFT52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32121
GSE142684_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248501_1_v_0_mst1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-79-AG41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244395
positive regulation of signal transduction	GO Biological Process Annotations 2025	1.0	null
HA-82-XO48_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.470128
BF-97-LS55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.613424
Gall bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE172490_5_v_1_junb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224556,GSE224557_6_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6932815-ppat.1007634.s015.xlsx-ST5_DGE_ELF1-R8AvIFN48-mock_lfc-external_gene_name_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142210_2_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
SAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08863
PRELID3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69741
PMC9437808-mmc3.xlsx-IPA_Upstream_regulators-IPA_Upstream_regulator_analysis_Up_regulated_genes_following_LPS_treatment_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
VPS52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0079
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.936886
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216936
BE-33-IM71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322272
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
ERFL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29399
PAK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.09943
AD-00-WA10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.421165
RNF216	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03413
LENG8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4806
GSE148066,GSE157787_2_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TEX19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19889
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-58-FJ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232649
AD-11-RL84_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.604847
496100410_TCx_possible Alzheimer's disease_TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.5081
GSE210655_3_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Change_in_both_CSDE1_KD_hESCs-hgnc_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE87412,GSE92423_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DB-28-SP20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262792
BE-70-YH17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307976
HLF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21211
SENP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65743
Peripheral vertigo	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
EE-98-PF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221034
GSE135030_11_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ALKAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59699
Colitis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.101
very-low-density lipoprotein particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.208
MEX3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29703
TMEM19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2618
MRPL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23728
Sweet taste receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.78
GSE247764_0_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135030_3_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MARF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21281
Arteriosclerotic cardiovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.667
AB-80-CK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215729
SRSF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47866
WC-67-DI84_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.638089
496100448_TCx_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.1328
GSE165174,GSE165175_0_v_1_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CDK16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62033
regulation of insulin receptor signaling pathway	GO Biological Process Annotations 2025	1.0	null
ADAM8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14073
GSE148066,GSE157787_3_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11116544-41698_2024_606_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_4_Significantly_differentially_expressed_genes_between_TCGA-HNSC_patients_carrying_amplified_MYC_and_wild-type_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE234340_1_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211983_1_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Oviductal fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.809
HD-51-KD29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.426485
TMEM131	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17539
ANKRD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36875
LA-42-ER00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.312625
GSE207582_4_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
OB-06-WW76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.522394
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	94.4432
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.111
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225392
Tbx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.7508
PMC5575985-mp2016192x3.xlsx-ST12-Unnamed_1_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202434,GSE202438_15_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.221
Benign paroxysmal positional vertigo	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.265
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7883
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.5349
GSE113106_2_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.9178
GSE131798,GSE131804_1_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CD-88-UF56_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209523
AD-86-OB87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.547096
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SA-32-CC58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.852868
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.3427
positive regulation of D-glucose import	GO Biological Process Annotations 2025	1.0	null
GA-77-MH38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250059
SHREC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.611
SMTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95441
GSE136869_1_v_0_lpar2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE132694,GSE132717_0_v_2_meis1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE145628,GSE145629_1_v_0_myrf_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6520398-41467_2019_10148_MOESM11_ESM.xls-FigS1a-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216538_1_v_3_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
receptor ligand activity	GO Molecular Function Annotations 2025	1.0	null
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.52721
GSE216538_7_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210655_3_v_7_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Gastric ulcer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.558
AA-17-RC87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200794
Ureteric bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.077
negative regulation of carbohydrate metabolic process	GO Biological Process Annotations 2025	1.0	null
PLP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56899
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.490727
GFY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59813
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227541
GSE96641_3_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157594_6_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CD-35-BD44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.08621
Immune system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.101
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.35558
GSE247764_1_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CA-25-LR28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259989
BD-96-HO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334032
GSE127790_10_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.9756
ZSCAN29	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4501
GA-18-KF56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.443282
GSE189834,GSE189836_1_v_0_brd4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203308_4_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE124410_2_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	94.7558
Brain - Hippocampus	GTEx Tissue Gene Expression Profiles 2023	1.0	3.23112
GSE148066,GSE157787_8_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203308_15_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Foam cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.333
DA-35-DU85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.490571
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243802
BB-86-BE19_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.373549
JB-75-NC66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.401967
STOML1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92138
ASS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12798
GSE151782_3_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DC-22-OP01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.21985
Subcutis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.288
Oviduct epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.567
GSE120595_5_v_1_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_15_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223008_5_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TIGD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.17857
GSE232223_1_v_0_letmd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LA-44-KW22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.324887
chr1_1244420_G_A_b38	GTEx eQTL 2025	1.0	1.05017
AGA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20013
BD-38-QC39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.695584
GSE153189_2_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142684_2_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JC-02-ZR15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260847
NUDT15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91859
MED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08695
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.642083
GSE180200,GSE180201_2_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BF-49-QA17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.572045
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JD-62-HR05_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219659
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1333
ZNF343	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.881
GK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71186
Viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.062
TTC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9452
GGT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20646
SDE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53342
PMC7914369-thnov11p3676s2.xls-BPTF-KOvsCtrl-AccID_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
TLE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59529
GSE200687,GSE200688_1_v_0_sox15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GF-37-MB64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.369015
NUP205	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59674
GSE114992,GSE114993_9_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE165122_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Ar	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.2891
PRKAR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80875
PAGE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45006
3T3-L1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.601
FAM229B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59
Ovarian dysfunction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.568
RPS23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15967
PMC5503541-oncotarget-08-38399-s003.docx-1-EVX1_EVX1	Rummagene Transcription Factor Associations 2026	1.0	null
PKN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.27447
CCDC124	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.48373
AA-99-PN83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.09249
TATDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11762
GSE140651,GSE140653_2_v_4_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DGCR8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87356
GSE163884_1_v_0_sumo2_human	RummaGEO Gene Perturbation Signatures	1.0	null
FD-72-CE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.385374
TFDP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6966
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.368546
PMC6420765-12864_2019_5550_MOESM5_ESM.xlsx-D9_vs_D15-Unnamed_1_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
EXTL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01755
CENPM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45972
DFFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58525
GSE246195,GSE246305_2_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HMOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95412
enlarged seminal vesicle	IMPC Knockout Mouse Phenotypes	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.56998
AD-53-VC77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.421079
AD-06-OB47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210006
C3orf52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66221
SPEGNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08787
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Coronary atherosclerotic plaque	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.641
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.30267
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.393015
GD-46-BU97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318764
Gastrointestinal tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.062
Wing	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.392
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.615739
IQSEC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.02576
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.715
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.49424
GSE110178_2_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TEX30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39755
Arteriosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.696
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.7075
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.699026
GSE212299_3_v_0_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SPRED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.631
LSG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25088
EB-82-HZ30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.415999
GSE144231_4_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165122_2_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DIPK2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52041
GSE135705_5_v_3_corticosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE218580_1_v_0_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Glucose intolerance	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.456
PMC12179083-Table_6.xlsx-VCF_Variants_Master_File-Gene_TBX1	Rummagene Transcription Factor Associations 2026	1.0	null
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.572471
DENND4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.07081
GSE165682_4_v_3_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154464_1_v_2_cdk6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261869
WB-17-DI74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28387
TLR7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18674
HA-22-CY42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287995
CDC123	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75528
ED-71-GA72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.344275
GSE188869,GSE188871_2_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Connecting tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.666
GSE75976_3_v_4_abl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.8153
PMC5537054-NIHMS836474-supplement-3.docx-0-DMRT1_DMRT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE205332_2_v_0_queuine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHRNA9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.13968
Polycystic ovary syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.597
GSE120595_0_v_1_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157594_3_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_2-1769_genes_are_more_than_four-fold_upregulated_in_PRDM8-_-_compared_to_control_PRDM8	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184884_6_v_5_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DD-54-MA35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.367436
STX16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.9708
GSE100316_7_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.395
EIF4A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30403
POU2F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23832
ARHGAP23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88541
Hyperglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.399
GB-73-QS80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.50608
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.1651
GSE148695,GSE167284_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.403788
T2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.913
MYNN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11871
PAK1IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97385
GSE223008_4_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12499388-ADVS-12-e01774-s002.xlsx-Table_S1-Table_S1_Differentially_Expressed_Genes_between_wild-type_and_TET3-knockout_PANC-1_cells_TET3	Rummagene Transcription Factor Associations 2026	1.0	null
GNG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76613
ZNF837	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16361
GSE142232,GSE142234_0_v_3_gcgr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-66-NV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.385118
KPTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.47831
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.57768
TM7SF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11868
GSE138019_3_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MFN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07267
SA-32-CC58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.770498
CLOCK-BMAL transcription complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.602
SFRP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56492
RRP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32051
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202309
FD-20-OG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217117
ZA-63-AC60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.475246
AD-55-WK61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.472209
GSE155695,GSE155696_1_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PLTP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94477
SMAD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84119
AHR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.74876
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PLAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10247
LARP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45171
PMC7064337-elife-51373-supp1.xlsx-EZH2_targets_shPHF19-List_of_2084_genes_marked_by_EZH2_ChIPseq_after_PHF19_KD_shPHF19_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HA-17-MS45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27289
GSE211177,GSE211178_9_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PDCD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32813
MMACHC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.42631
Primary immunodeficiency disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.101
NAA10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.14553
CCDC66	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03966
INSYN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50388
ERF::NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.1352
GGPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27174
DE-34-DT75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268191
EA-84-SC49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.738765
MFAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41831
PROP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32177
Longissimus thoracis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.006
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.653
BC-13-OQ01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.331281
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279046
ACTB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35848
MAT2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42381
RD-92-QT24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.353735
BD-04-NG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221856
TACC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31252
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205066
negative regulation of gluconeogenesis	GO Biological Process Annotations 2025	1.0	null
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277168
ASTE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41948
H1-7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.61138
ADRA2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07334
DRAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46354
GSE104508_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LIMK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.984
DMRTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20749
PRDM11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91608
FAM98B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63766
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.405687
VA-92-QP54_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.724407
Adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.042
AA-11-RO46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221136
CORO2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23119
GSE110268_2_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150669_0_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-71-CI37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.735892
Peritoneal cavity	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.446
ZNF483	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30333
GEMIN8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39549
POLR1H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31261
CB-88-LG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.315205
UTP14A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90313
MA-06-DJ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30962
GSE135514_8_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE96991,GSE97117_5_v_2_il11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FB-32-PY27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2477
Allantoic fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.747
ZBTB7A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3163
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.565669
S0-EE-XKW4_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25886
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.571845
GSE116299_4_v_3_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE116354,GSE117379_2_v_4_cox2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110178_1_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-SP1_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.28
Neointima	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.419
PMC12178829-mmc4.xlsx-Sheet_4-MEG3-KD_Up-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MYO5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86524
NQO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5801
GSE140441_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216538_7_v_2_mrs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35047
GSE44157,GSE44163_3_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184902_4_v_1_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE228181_0_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.426669
MD-49-BL92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218969
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.448206
H2AC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11812
ZNF574	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.2162
Brain - Cerebellar Hemisphere	GTEx Tissue Gene Expression Profiles 2023	1.0	2.11948
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.609447
PIGM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24642
OB-06-WW76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.438122
GSE166315_5_v_3_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE143643,GSE143644_3_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DNAJB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82875
PIP4P2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.55512
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.654924
GSE224969,GSE224971_0_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE102486,GSE102490_1_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MMD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57407
GRWD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41109
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.351523
AF-99-HA02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246452
FMO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.93081
GSE120413,GSE120447_4_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE96641_5_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203308_15_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
negative regulation of small molecule metabolic process	GO Biological Process Annotations 2025	1.0	null
RD-90-OY66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.374716
CDCA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67777
GSE234340_3_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NE-00-JZ19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.817736
TA-19-YA45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.385854
JF-30-FW92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25638
GB-64-HC34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204054
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.468883
GSE202434,GSE202438_3_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PPP3CA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99827
Cervix - Ectocervix	GTEx Tissue Gene Expression Profiles 2023	1.0	3.53258
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.72593
ZDBF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65252
ZNF549	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.3396
KC-32-GO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.687685
DD-74-PJ26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224479
GSE182727_1_v_0_busulfan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
platelet-type bleeding disorder 14	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.444
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318107
PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Gene_Name_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
PRMT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66408
SA-03-IQ14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.349594
PMC12178829-mmc4.xlsx-Sheet_4-MEG3-KD_Up-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Change_in_both_CSDE1_KD_hESCs-gene_short_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
AE-51-ZO26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291542
GSE149870_0_v_1_pfn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.283292
GSE180200,GSE180201_3_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YA-85-VH07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284642
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.386109
FA-88-II68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.720203
NKX6-3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.377
DE-48-HZ49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239543
SMG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12404
GSE149000_2_v_0_cyp3a5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
DF-93-BT88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334508
CHRNA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63987
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.15151
GSE147210_2_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CDC42EP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69695
GRAMD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66803
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	85.0959
CC-09-YG11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284709
PTCD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36076
GSE234340_10_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MA-58-RR04_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228551
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.76421
GSE96641_1_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.53144
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.972457
GSE84922,GSE84924_0_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.40366
ZNF454	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	147.233
AD-29-IG16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.865615
KDELR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58584
SUZ12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30196
GSE166315_5_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114992,GSE114993_9_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_13_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE188870,GSE188871_0_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211177,GSE211178_8_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AB-97-BI36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27351
GSE210951_1_v_0_islr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248045,GSE248046_0_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100401_FWM_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.18369
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286047
PMC8285542-41467_2021_24656_MOESM4_ESM.xlsx-Sheet1-The_genes_positively_or_negatively_correlated_with_TP63_in_SCC_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142210_4_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Intestinal disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.444
ZNF682	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	79.3336
ZNF131	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23227
PMC7794364-41540_2020_161_MOESM3_ESM.xlsx-NSP_Unique_-_PPH2_predictions-Gene_Sym_SMAD9	Rummagene Transcription Factor Associations 2026	1.0	null
BA-39-HG26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.762394
S0-EE-WW96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220434
OD-30-JC39_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248768
GSE193588_1_v_0_pax3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE228894_0_v_1_rnmt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NKX3-2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.25469
UBE2D3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65976
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
ZNF235	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43123
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.890769
PMC8582123-13073_2021_996_MOESM4_ESM.xlsx-SATB1-HIT_SATB1	Rummagene Transcription Factor Associations 2026	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.846
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157594_6_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147662_0_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE248858_4_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE228162_2_v_5_nr2f6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100580_PCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.28293
GSE184884_6_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Rectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE101546_2_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE124410_6_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.629009
HD-29-LW24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.369317
PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-DMOG_-_HIF1A-gene_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
DCAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56477
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.069
GSE153341_2_v_3_atf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BA-39-HG26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.400231
ATIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45344
BC-13-OQ01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.375023
GSE155305_2_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LSM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18706
GSE168171,GSE168173_0_v_1_ddx41_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE60367_2_v_1_cxcr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260798
MA-31-VM30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.346032
CA-66-YB17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.74621
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228547
GTPBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58759
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3973
GSE117042_1_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE164135,GSE164137_0_v_1_fbxw7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BOP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84631
NAA60	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1311
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25887
GSE199092_3_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE129287_0_v_1_cd200_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.438563
INTS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69022
GSE147210_3_v_4_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GINS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83189
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.939
EBF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.334
PMC5417597-pone.0176679.s006.xlsx-Tumor_MLL_vs_AT1-Unnamed_1_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
TGFBI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66591
CDT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54291
regulation of D-glucose transmembrane transport	GO Biological Process Annotations 2025	1.0	null
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	214.906
ZIC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.7463
GSE101546_3_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
ABT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54274
FB-66-UU47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.335707
RRP36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03985
TLNRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28686
GSE184884_4_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.062
GSE223893_11_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-74-RX30_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211464
AE-13-CX28_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.424894
GSE138019_1_v_5_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE95685_6_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RTRAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86635
ELOVL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93762
OLIG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32195
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.062
NDUFAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51049
NF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.86499
Schwalie et al.Nature.G2_Adipose tissue_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
AB-30-CR11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.549373
AE-19-BK71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.314516
GSE203485_1_v_0_zdhhc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Zfx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	46.6334
KA-75-LP02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211992
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.320016
RAB1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18437
C11orf24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54669
GSE118766_2_v_0_ifng_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.28456
GSE190555,GSE190557_2_v_3_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
NAA38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41187
GOLGA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67032
JB-23-ZE86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207084
Metanephron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.773
SNX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03334
SEMA7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76293
QB-99-OU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282358
DE-34-DT75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221572
STAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22346
AA-52-JS03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.804178
MASTL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43213
Abdominal adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.52
APH1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79192
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.585118
ZFP92	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3114
Gynecophoral canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.932
GSE137914_0_v_5_tet3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
L3MBTL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16154
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HB-87-YY34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.505416
CB-13-ZM96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239978
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Gene_Name_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
NVL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16408
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	223.655
vs86	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.942
S0-EE-Y79N_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217779
GSE164874_5_v_14_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
EMILIN complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.852
FAM131B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01527
AD-52-UZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240883
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.729
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265644
GNAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13003
absent seminal vesicle	IMPC Knockout Mouse Phenotypes	1.0	null
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.9995
GSE86507,GSE86509_4_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE144231_3_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CD164	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4732
SLC12A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39006
BE-92-TW08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246356
Amniotic cavity	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.692
ARFIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23625
GSE147662_3_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PPP2R5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42541
RAB22A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07979
LCMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57526
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.04349
MA-58-RR04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.412142
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-ID_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
PLK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22084
ZNF773	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25512
PMC12173678-mmc2.pdf-20-SNAI3-AS1_SNAI3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE229468,GSE229471_0_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
UTF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.55904
GSE120413,GSE120447_3_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RD-66-DP49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23135
CNKSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13456
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.475497
OB-17-DQ74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222118
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Decreased_in_both_CSDE1_KD_hESC-hgnc_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	293.205
regulation of gluconeogenesis	GO Biological Process Annotations 2025	1.0	null
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.1316
Subcutaneous adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.305
PAX9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33634
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.362729
SCN4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60935
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248626
TMTC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07501
NPEPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50886
GSE139948_3_v_2_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12179525-mmc1.xlsx-Group_HNF4A_vs_Null_sign-Supplemental_Table_S1_Differentially_expressed_genes_in_HNF4A-transduced_cells_vs_Null_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF571	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.36631
CTNNAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39887
GSE207582_2_v_1_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ERAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04218
Anchored component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.659
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.111
Vesicle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.986
PRDX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.4375
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
BCL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42588
BE-90-YK54_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24416
CSNK1G3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26674
Chondrocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.723
MITD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17598
BLOC1S4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44088
GSE93309_2_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100323_FWM_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.9141
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220279
Esophagus - Mucosa	GTEx Tissue Gene Expression Profiles 2023	1.0	2.34557
FBXO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.93969
496100378_TCx_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01375
GSE136622_0_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE73381,GSE73382_0_v_1_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EE-01-FB85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.304692
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	96.2335
Gestational diabetes	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
E2F7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88793
NPM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48386
SMYD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42726
GSE203308_4_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130383_2_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EFL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95468
CTCFL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.3009
GSE161295_0_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.7856
positive regulation of insulin receptor signaling pathway	GO Biological Process Annotations 2025	1.0	null
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.364684
AC-50-FR41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223236
ZD-18-MI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.428349
TNNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66299
GSE210655_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
C1QTNF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76628
GSE248045,GSE248046_0_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257379
MUSTN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00079
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	229.273
GLIPR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.69777
ATP6V1F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56232
GSE122067_2_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147662_3_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
VCX3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7785
GSE112860_5_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Atherosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.667
PHOX2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53193
QA-14-AU91_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.389375
GSE203308_1_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE124304_1_v_0_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE136894_1_v_0_psen1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PPM1K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10884
GSE196104,GSE196106_2_v_0_vsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SC-25-HE80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30741
PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
CHST10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60999
GSE255432_4_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TMEM214	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8733
NIFK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05604
NEIL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82205
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240283
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259926
CB-02-XL81_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.405885
EMSY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44724
ACADSB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22839
FAH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12717
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.343834
CCNJL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52566
CB-02-XL81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.647009
MAPK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04382
CB-24-AT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.73484
PMC5358377-pnas.1615015114.sd02.xlsx-Sheet1-Genes_with_VDR_elements_only_control_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112761,GSE112767_4_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146840,GSE146842_3_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180200,GSE180201_2_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DLGAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26968
SOX15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0186
GSE202284,GSE202289_3_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DF-00-BX35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.483442
GSE186739_0_v_1_asic3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224969,GSE224971_3_v_7_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AC-84-QG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.406267
TLK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98719
IC-05-AW29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.741905
GSE148692,GSE148695_2_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148066,GSE157787_5_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FA-89-PW29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204046
DA-56-CH26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202632
Complement component C1q complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.663
GSE97278,GSE97280_2_v_3_nsd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224556,GSE224557_8_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11336098-41598_2024_70235_MOESM1_ESM.pdf-220-ZBTB24_ZBTB24	Rummagene Transcription Factor Associations 2026	1.0	null
JPH4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40401
GPR27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31361
DNAJC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7448
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245557
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	77.0767
AD-88-WG84_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227998
FHL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.08805
GSE112860_3_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184902_4_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PROX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6147
USP24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02449
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.624421
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DE-73-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.356506
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
MSRB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96624
GSE113385_0_v_1_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3357
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.039
GSE248045,GSE248046_4_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.948
SCOC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16914
GSE211226_1_v_2_sirpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE168596_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
White adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.853
GSE219195_0_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209983
EF-74-KW12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271277
GSE131161_1_v_0_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Coronary stenosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.234
GSE98964_1_v_4_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PB-09-OE00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.42936
IGSF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.37193
GSE152937_12_v_7_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203308_14_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SLC16A13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15034
GSE114258_1_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZIC5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.4768
FNBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7689
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.445025
THBS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21487
NDUFB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15942
MYL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4111
YA-92-YO01_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212042
SLC1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55642
GSE165636_0_v_4_tofacitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WEE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42886
RBBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.21282
Longissimus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.017
GSE112761,GSE112767_2_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MARCHF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91765
Systemic lupus erythematosus	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.539794
GSE223008_11_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227891_5_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
STIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28226
OB-06-WW76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220043
PMC6932815-ppat.1007634.s015.xlsx-ST5_DGE_ELF1-R8AvIFN48-mock_lfc-ensembl_gene_id_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
HUS1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05848
GSE86507,GSE86509_7_v_2_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56129
GSE139239_2_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE150669_2_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Change_in_both_CSDE1_KD_hESCs-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
AE-13-CX28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.475125
GSE255432_7_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Intramuscular adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.981
GSE100316_0_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6439317-Table_4.XLSX-NR2F6-Supplementary_Table_4_Genes_with_significant_correlation_with_NR2F6_NR2F6	Rummagene Transcription Factor Associations 2026	1.0	null
AA-11-RO46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.33569
BEX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00846
E2F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42851
GSE133683_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Decreased_in_both_CSDE1_KD_hESC-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE127790_6_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE113734_1_v_2_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IFRD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90941
GSE180200,GSE180201_3_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GDPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1547
HA-99-PM50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251056
SSTR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20835
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.4065
UBE2W	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9113
GSE171175,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF816	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.9981
GSE138019_1_v_2_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF121	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.55294
DHFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49865
TM9SF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69191
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.955
AA-56-QO38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.537428
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.6552
ESYT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.56454
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225312
496100641_PCx_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.06575
FUCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28952
GSE148692,GSE148695_7_v_6_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FA-36-VA24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.375736
GALR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47958
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.444
EXOSC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04569
ED-33-YZ72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.308466
Adipocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.808
GSE210655_3_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-00-YH62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.301092
PMC8569982-41065_2021_205_MOESM1_ESM.xlsx-mono_THP1_a2b_tpm1-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
LIN28B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01432
THTPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6788
GSE217873_1_v_2_nusap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168750_0_v_1_slc7a5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_11_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BB-87-SF89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330384
Macrophage foam cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.212
BE-27-XF09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.326844
GSE101546_2_v_1_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154767_4_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE247764_4_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SIGIRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71598
SKIL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4117
CARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77059
GSE84148,GSE96938_0_v_2_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Sacrospinalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.98
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.727414
YA-44-LW45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.403855
BC-01-JL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.37923
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4399
GSE150669_2_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
C14orf28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37053
GSE164364_2_v_1_zymosan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE203308_9_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CCDC82	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22992
ZFP36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76367
L3HYPDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17058
GSE87412,GSE92423_3_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE218907_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UF-06-JB00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.340502
WC-33-YP46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.335703
GSE137914_0_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PNPLA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38109
FUT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04179
ZNF513	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56776
GSE96641_1_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96008
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.442003
TLE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10228
CCHCR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08609
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
GSE152432_1_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.1591
GE-63-WI86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300301
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.0936
GSE96641_5_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CHFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35015
FRMD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00053
GSE97278,GSE97280_2_v_1_nsd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE116433_1_v_0_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE228413_0_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE127970_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BTF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5642
GSE110440_1_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ARPC5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.00981
Ulcerative colitis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.101
496100393_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.12089
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
negative regulation of biosynthetic process	GO Biological Process Annotations 2025	1.0	null
PMC6831824-mmc7.csv--IRF4_IRF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE100316_3_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.35399
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.348832
GSE223008_4_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.801
DUSP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19977
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE124410_6_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Feather	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.464
NA-30-HS87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.410362
WASF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73168
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.479747
DCTN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72191
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233781
BE-59-WG31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22435
GSE235390_4_v_0_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Thygro-r__CIC-1n_h-r__CIC-2n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
BCCIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.90296
GSE203308_6_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.12795
CAMK2G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87096
GSE228894_3_v_2_rnmt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HIT-T15 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.849
GADD45G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17002
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.062
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336309
PMC8755441-mmc3.xlsx-IRF7-Up-Symbol_1_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE157594_3_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KA-29-AB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.91433
PMC11528209-cd-23-1212_supplementary_table_s7_suppst7.xlsx-A549_EML4_KD_DEGs-List_of_DEGs_of_EML4-knockdown_vs_control_A549_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
AE-71-CB15_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251228
MCM9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34846
ZNF417	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5556
QE-18-WG07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.753301
GSE148692,GSE148695_7_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BLOC1S6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.91553
GSE202434,GSE202438_3_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5550424-41467_2017_212_MOESM4_ESM.xlsx-Hematlas-Genesets-PITX2_PITX2	Rummagene Transcription Factor Associations 2026	1.0	null
FA-36-VA24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263143
positive regulation of cellular response to insulin stimulus	GO Biological Process Annotations 2025	1.0	null
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	79.6047
BD-61-OO16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232896
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.59599
AF-83-BX08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.486162
SERPINE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39309
hormone activity	GO Molecular Function Annotations 2025	1.0	null
ZBTB7C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0116
TTLL8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.40797
CE-18-AP85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234074
496100622_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.93435
AC-84-QG99_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27493
GC-04-UF36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203899
ZNF320	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	157.988
AA-76-VE74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.351207
GSE137818_5_v_0_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153189_2_v_0_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BE-59-WG31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.290937
ZNF263	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.3559
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.425309
MFAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01174
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.33817
HNMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20712
LAG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88305
IA-76-ZU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.385324
LYSMD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06182
GSE219103,GSE219104_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.183
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.51381
TTLL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.58425
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284359
Autoimmune disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.101
PSMG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8688
CB-16-SY72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.406197
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	209.802
LRRN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29026
GSE173810_4_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Nearest_Ensembl_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
JD-00-YJ41_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271252
GB-45-YG91_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235949
SMARCAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74593
GSE210655_1_v_6_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5926
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.5939
GSE148252_7_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MA-43-MR37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.616421
Protoscolex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.5
ZNF610	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	83.1123
PHF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97368
RABL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00363
FD-48-HZ39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.367958
Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.0025
GOSR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05725
GSE101546_3_v_4_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EIF4E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47933
CAMKK2 pathway	WikiPathways Pathways 2024	1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275208
GSE149264,GSE149267_9_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EIF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19318
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_E20_814_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CCDC160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14273
496100368_PCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.16602
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.044
AVPI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80393
GSE199034_1_v_0_pirfenidone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PKMYT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56874
PMC8755441-mmc3.xlsx-IRF7-Up-Symbol_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE71529,GSE71558_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-N417 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.252
PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Nearest_Ensembl_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
GPRASP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78671
IB-56-JN40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.885092
JE-72-KV75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235403
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SF3B6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32694
EBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.7928
CE-18-ZM38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237457
YC-45-JD42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.503764
JB-75-NC66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239114
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	87.9163
SYCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2661
GSE131660_2_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BF-89-QD24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28615
DA-66-OE69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.42547
GSE213442_1_v_0_kpna2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100483_FWM_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.57415
Alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.062
DB-18-UF01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.351236
NCOR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6415
GSE165579_0_v_1_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18984
RASSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17322
GSE171177,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE68155_1_v_0_gpr3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AB-18-YN11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.338741
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.1934
ACSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16545
PMC3610249-1471-2164-14-184-S4.xls-miR-331-3p_targets-NR2E3_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
GPR20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.37241
PMC11046918-12967_2024_5211_MOESM4_ESM.xlsx-F_HT1080_FUS-DDIT3_regulated-Table_S2_Regulated_genes_between_scaffold-cultured_and_monolayer-cultured_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEx Vagina 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-3.11404
ZNF551	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54517
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6818
SUPV3L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26894
GSE142684_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10901781-41467_2024_46134_MOESM12_ESM.xlsx-Supplementary_Data_9-Supplementary_Data_09_Differential_expressed_genes_in_RUNX1-mutated_AML_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300897
CB-02-XL81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.452477
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.4248
AC-75-LR63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.386989
Adipocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.705
GSE183113_2_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.07602
PAQR9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16096
AA-88-PJ86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238643
OTULIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63934
WC-67-DI84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211666
FUT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91017
GSE226181_3_v_2_akt1s1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118766_1_v_0_ifng_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206427
GSE158502,GSE158506_3_v_0_fat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-62-RZ55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.35112
Allantois	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.67
FAIM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12272
FE-82-WB22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.349944
GSE184902_4_v_1_adipor1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE248045,GSE248046_6_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lipid metabolism disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.373
CF-48-QD87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.495933
AC-30-XU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.49919
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.437
GSE90019,GSE90020_5_v_2_phf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-83-ZM06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.29501
GSE211177,GSE211178_4_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AD-86-OB87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345516
RD-50-EO07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.691783
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10282096-41467_2023_39038_MOESM4_ESM.xlsx-All_genes_Upregulated-ENSG00000177426_TGIF1	Rummagene Transcription Factor Associations 2026	1.0	null
UBALD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09374
GOLGA6L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59355
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6827
PBXIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.02043
ME-31-RM40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227529
PCTP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42512
496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.03222
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.8955
NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.0475
Duodenal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.537
FHIP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86227
1p36 copy number variation syndrome	WikiPathways Pathways 2024	1.0	null
SNRPD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69454
CC-50-FK24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.320502
GSE158197_5_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10534007-Table_2.xlsx-S1_overlap_MSC_up_B_V-438_common_elements_in_BFTC905_MSC_up_and_VM-CUB1_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
HM13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69361
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE139427_2_v_1_ibrutinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FRAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21366
RC3H1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55322
GSE136622_2_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYO10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02873
GSE110178_2_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TSPAN14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29165
ALG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97493
GSE133505_5_v_4_myf6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FURIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65833
ZMYM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.479
PMC13187244-41392_2026_2766_MOESM2_ESM.xlsx-Table_S18-Table_S18_Differentially_expressed_genes_in_OCI-AML3_cells_ZMIZ1_inhibitor_SIH-002_4H_vs_DMSO_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.723275
L2HGDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43993
Gastrointestinal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.444
TMEM59L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40882
GSE225141,GSE225143_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FE-64-KC49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229412
PMC8185471-mmc4.xlsx-D4-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_4_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
PLAG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	155.111
DA-81-VY50_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20904
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.708775
EE-18-HW72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261849
GSE225656_0_v_1_tsc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5918774-13287_2018_864_MOESM2_ESM.xls-sheet-AF_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE254848_4_v_3_ptges_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148066,GSE157787_8_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JF-16-BD66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.310514
GSE138019_4_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE225656_2_v_3_tsc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PET100	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10244
LTO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98812
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.830029
ANAPC15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91092
CDK10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03474
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.706478
TERF2IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41448
GSE186707_1_v_0_hdac4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
USP22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.64339
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	86.8212
OCRL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23864
GSE158197_0_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.988
ZNF738	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.74262
TF-77-DW08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.293751
IKZF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07168
MRPS25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16102
positive regulation of D-glucose transmembrane transport	GO Biological Process Annotations 2025	1.0	null
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.769
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.351426
BLTP3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42693
GSE176093_2_v_3_mineral oil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FAM53C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1434
Feather vane	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.799
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8576
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.5323
GSE138001_2_v_3_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.3545
GSE118794_0_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MSLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91678
GSE157594_0_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE250534_2_v_3_cabergoline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CCNH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8181
JD-44-KF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.545561
CB-73-HZ47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259286
PABPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72263
GSE161064,GSE161065_0_v_1_kdm5b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE247764_3_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE246911,GSE246913_4_v_1_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.328658
RILP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.172
BE-73-KD75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216538
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.444
DB-18-UF01_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268452
Neutrophilic myelocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.895
Tfcp2l1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	71.8614
mitochondrion-derived vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.795
triglyceride-rich plasma lipoprotein particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.2
PMC12586484-41598_2025_22484_MOESM2_ESM.xlsx-Supplementary_Table_1-Supplementary_Table_1_DEGs_in_ATOH8-depleted_EVT_ATOH8	Rummagene Transcription Factor Associations 2026	1.0	null
CLK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45154
Metabolic dysfunction-associated steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.147
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.544334
FA-88-II68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.458611
DNAJB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85963
GSE184902_4_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203485_1_v_0_sunitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100305_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.49512
RBM14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71002
ABRACL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32966
GSE148252_1_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DB-24-CQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231128
FD-20-OG99_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.421885
AF-30-GH67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.409877
BB-87-SF89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245668
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30871
Coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.725
BB-10-PR06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.36607
APEX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.68043
FE-29-XM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230219
KLF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.6758
KIF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97543
HSPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28655
GSE213632_3_v_6_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MRPL41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43672
GSE254848_4_v_13_ptges_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF132	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85467
GSE151612_0_v_3_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41205
PMC5792454-mmc2.xlsx-Table_S5-Table_S5_Genes_up_or_down_regulated_in_murine_Hoxa9_IRX3_leukemias_versus_Hoxa9_MTV_leukemias_Gene_Ontology_annotations_IRX3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120413,GSE120447_0_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PSME3IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66155
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Autoimmune disease of gastrointestinal tract	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.101
RHPN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22492
GSE149366_1_v_0_sulconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
microphthalmia	IMPC Knockout Mouse Phenotypes	1.0	null
abnormal eye morphology	IMPC Knockout Mouse Phenotypes	1.0	null
ENY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65098
FAM177A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43188
ARMCX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59088
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.647498
Brain - Amygdala	GTEx Tissue Gene Expression Profiles 2023	1.0	2.176
HLA-DRB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.44384
GSE119603_1_v_0_oxaliplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.078
CHEK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18123
GSE248858_1_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Cpa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.662
KB-46-EJ60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277743
GA-47-MH68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.687153
NHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	107.332
GSE159967_3_v_0_arid5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NF-21-HQ00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.352724
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.363887
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.2002
GSE240645_1_v_0_u90926_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NXT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36633
TMEM68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64483
NC-27-AD53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259544
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.816277
BD-90-DK64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.507343
anophthalmia	IMPC Knockout Mouse Phenotypes	1.0	null
SERPING1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2765
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Decreased_in_both_CSDE1_KD_hESC-gene_short_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
WC-09-GD62_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292789
WF-96-ME07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.366913
GSE205332_1_v_0_queuine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF585A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49553
GSE138815,GSE138817_0_v_2_kdm6a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE144231_2_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IC-05-AW29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.525315
GSE161295_0_v_5_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7944
GSE113106_2_v_1_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CXCL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90531
regulation of D-glucose import	GO Biological Process Annotations 2025	1.0	null
FOXO3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16734
ZNF213	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	85.7729
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334038
GSE180200,GSE180201_5_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CE-48-TP40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223088
PMC10915192-ab-23-0304-Supplementary-Table-S6.pdf-25-FOXK2_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
AQR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37238
GSE152432_1_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DUSP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51126
GSE239541_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HAUS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77891
GSE166315_2_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-85-JR73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.613688
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.730541
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.4761
GSE202434,GSE202438_13_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.454673
GA-94-MC54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.685274
RPP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08628
GSE219195_0_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
FF-46-OR35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288227
GSE133683_1_v_5_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RPAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97547
MEAK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.593
HA-17-MS45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254948
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.4029
PIGP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36757
GSE196671_5_v_1_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3497
ZFP14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.0167
USP17L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80149
GSE148510_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Theca cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.818
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.918
ERH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00485
GSE152937_12_v_1_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Shell gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.081
LCK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67369
RPSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32493
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269141
GTPBP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57506
CDH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32981
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.282
GSE169691_1_v_2_saha_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE122711_1_v_0_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.524962
MMGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.75102
ITSN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53646
HOOK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34068
GSE150669_0_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AKAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34636
BTRC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.51194
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.530822
TWIST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29748
LCTL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51999
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30683
GSE166315_1_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148692,GSE148695_7_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE133691_2_v_0_lgr5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274377
GSE122378_0_v_1_carmil3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9376070-41419_2022_5157_MOESM15_ESM.xlsx-Sheet1-Table_S1_Differentially_expressed_genes_of_CYTOR-KD_and_NC_cells_identified_in_the_RNA-seq_analysis_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Inflammatory bowel disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.444
HAUS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7184
AC-49-NG46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269134
GMEB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.49397
496100407_FWM_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.17959
GSE117042_0_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE224969,GSE224971_3_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157594_5_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE185519_3_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF425	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84208
ACACA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27565
GINS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22724
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.56646
GNG11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47662
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.4857