association	dataset	threshold value	standardized value
GSE173394_1_v_0_nfatc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7914369-thnov11p3676s2.xls-BPTF-KOvsCtrl-AccID_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.3
GSE119345_0_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPLP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24216
GSE135030_8_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193258,GSE193259_5_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.28803
FOXI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40631
GSE135514_8_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11933697-41467_2025_58216_MOESM8_ESM.xlsx-SD6_ATF3_EV_NS1-SYMBOL_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
NUP160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53788
PMC8185471-mmc4.xlsx-D2-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_2_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.27509
NSUN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54152
DHX57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11045
SEL1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02597
RAN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50784
KIF22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01295
TNFRSF21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46944
DCAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2987
GNAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02022
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.21924
GSE130437_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EE-77-XO60_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301207
MCF7_SGI-1776 free base_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127863
TRERF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29418
JPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57663
PHKA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50792
POLR2I	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94721
PFDN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86065
GSE131660_2_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lymphoid-primed multipotent progenitor cell(LMPP)_Umbilical cord blood_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE60217_1_v_0_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE152055_2_v_1_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE106661,GSE106665_2_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_AC480_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201912
GSE149943_2_v_3_cd8a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF213	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25293
C15orf61	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02201
ENTREP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18247
KIAA1522	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03146
GSE222758_0_v_1_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11615365-41467_2024_54246_MOESM6_ESM.xlsx-KK47-Numb-KD_vs_Ctr-KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MCFD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2308
PMC10123531-NIHMS1874945-supplement-Table_S6.xlsx-SOX2_BCAT_cobound_peaks-Gene_Name_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
PYCARD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.6479
496100459_PCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.26828
K562_Zileuton_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149043
GTEx Esophagus 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	7.99971
GTEx Esophagus 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	17.9094
GSE132369,GSE132371_1_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NECTIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15783
GSE201270,GSE201272_5_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE172016_2_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165548_2_v_13_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155918
K562_Rucaparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216716
GSE111061_1_v_0_tofacitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.57849
GSE85874_4_v_5_kdm5c_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219736
GSE149901_2_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE110268_2_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SPEG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69513
RPAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82686
SQLE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02354
PMC10803041-elife-86204-supp2.xlsx-Bulk_-_Snc-KD_in_NM-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
BIRC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.406
SLC6A15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11598
DDX21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09039
CCZ1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.68438
ATP5F1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.541
K562_RG108_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156149
MRPS34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54552
TBL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09733
NKG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01092
GMNN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.60919
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CAPZA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10384
GSE165689_0_v_1_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEx Heart 20-29 vs 30-39	GTEx Tissue-Specific Aging Signatures	1.0	3.04868
K562_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140854
PELO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07582
UBAP2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10093
UBE2K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11541
GSE82032_3_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_MK-0752_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123649
PMC10769395-media-2.xlsx-S2D_EF_Repressed_genes-Ebegboni_et_al_Supplemental_Table_S2D_Increased_expression_following_depletion_of_EWSR1_FLI1_TC-32_TC-71_and_A673_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
NOBOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31307
GSE85874_4_v_1_kdm5c_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GAP43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34079
Azoospermia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.167
ATRIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.58331
MED9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96694
AKAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42166
TTI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3255
TFEB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08441
GSE196540,GSE196542_4_v_0_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CXCL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76537
GSE158834_2_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MVK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12414
POU2F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11444
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sleep disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.3
GSE144115_1_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DHRS4L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3019
PMC10169359-13058_2023_1653_MOESM1_ESM.xlsx-Table_S9-Table_S9_Genes_differentially_expressed_between_TP53_mutant_and_wild-type_pBCs_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
SGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32608
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ACP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53475
RNF139	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07324
chr2_97663592_G_A_b38	GTEx eQTL 2025	1.0	1.71566
CILP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28735
PALS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44075
GSE181513_2_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120612_7_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TTLL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82989
GSE171175,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230555
GSE160817_2_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
EAPP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34072
PROM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42551
ACE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6825
PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1d-List_of_2302_of_genes_differentially_regulated_by_SOX2_FDR_0_1_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
BLMH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86648
PMC12585103-pbio.3003444.s013.xlsx-List_of_genes_for_GO_analysis-List_of_genes_undergoing_significant_MXE_upon_PRMT5_KD_under_hypoxia_AR	Rummagene Transcription Factor Associations 2026	1.0	null
NEDD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19907
SFT2D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13549
DCAF15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47879
GSE184356_3_v_0_tfam_human	RummaGEO Gene Perturbation Signatures	1.0	null
PRMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5762
RSL24D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11946
MSMO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49064
KIF21B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29598
DLGAP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31864
HADH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12848
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
MAN2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1194
ZNF511	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44199
PMC9270251-mmc2.xlsx-2_Filtered_DEGs_Control_vs_KD_2-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154577_7_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DCTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02584
RBBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.21282
GSE103068_0_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100524_PCx_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.13116
GSE145249_1_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE77108_8_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RUNX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08479
TMEM69	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57438
SNRPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3201
GTEx Heart 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	1.0	8.01307
CENPP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24963
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169571_3_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TPSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15142
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Unnamed_1_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10335698-pone.0285806.s007.xlsx-DMKN-shRNA_KD_Vs_ShSrc-Unnamed_7_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE89154_1_v_0_proscillaridin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GNA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.72808
GSE216043_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-DMOG_-_HIF1A-gene_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
496100404_PCx_possible Alzheimer's disease_TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.19629
GTEx Heart 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	3.69554
MRPS15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65737
CCDC80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72445
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.82699
GSE141143_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Differentially_expressed_genes_identified_in_bulk_RNA-seq_of_FOXO1-_-_vs_FOXO1_hMSCs_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78257
GSE188869,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OXSM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65849
GSE202359_1_v_0_rbpms_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TFDP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65596
GSE182185_0_v_1_pstk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE179002_2_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE164874_5_v_1_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168369
GSE116930,GSE116935_3_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE164874_5_v_12_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PRR11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54643
NUP153	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7736
GSE119978,GSE180930_0_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
B3GNT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79381
UACA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29533
GSE135030_11_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE121824,GSE121826_0_v_8_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MED21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80863
HBS1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44152
PPAN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72225
SNRNP35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0777
MEX3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62978
Temsirolimus_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0164566
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259961
AGGF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40426
GINS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02585
GSE116930,GSE116935_3_v_6_hes7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
VCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5716
Infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
496100357_TCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.03818
GSE164874_5_v_10_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10245467-mmc3.pdf-250-ZNF888_ZNF888	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
DCAF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.9805
GSE161800_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Barasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129328
GSE165548_2_v_4_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Meprednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168285
SUMO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07116
GSE152032_3_v_2_s1pr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110580_1_v_0_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
DIP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0015
FBXO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54331
EML2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09813
MCM10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34726
MAGI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11846
GSE192860_0_v_1_trifluoperazine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GOLT1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12889
K562_Pirarubicin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150222
GSE149355_0_v_1_esrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140576_0_v_2_plag1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11392820-41556_2024_1475_MOESM3_ESM.xlsx-Supplementary_Table_9-Supplementary_Table_9_Expression_level_of_OTX2_targeted_genes_n_999_related_to_Figure_6_OTX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242290_1_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.71896
S0-EE-Y737_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229251
LAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77164
PMC12616242-can-24-3452_supplementary_table_s4_suppst4.xlsx-EWSR1-FLI1-KDM6B_genes-Genes_associated_to_EWSR1_FLI1-KDM6B_peaks_in_A-673_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
NSFL1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38679
GSE160817_3_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
WDR5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24509
RPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2068
VCAN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35637
RPS28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16953
DMRTB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.238
PMC11024925-mmc3.xlsx-Gene_lists-MV411_FOS_ChIP_and_RNA_overlap_after_10_nM_Gilteritinib_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CCDC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99633
CELF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29759
PMC11615365-41467_2024_54246_MOESM6_ESM.xlsx-KK47-Numb-KD_vs_Ctr-KD-ensemblGeneId_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE145249_0_v_3_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
ECT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3968
SREK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48327
SDHA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12569
TTK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58584
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235066_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPS18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07349
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.295804
GSE226285_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.10606
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.81813
KIF20B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03679
GSE158893,GSE158916_0_v_1_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE249404_0_v_1_oxytocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TENM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39017
ATP5MF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82426
MTFP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46966
GSE207582_4_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CDK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2584
GSE234514,GSE234516_1_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE167956_1_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226285_3_v_0_nr0b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZZEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20188
GSE146074_1_v_11_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_2_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE132369,GSE132371_3_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ATXN7L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19677
ARL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00462
GSE168604,GSE183859_1_v_0_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TAF1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3456
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292536
GSE226584,GSE226589_2_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169571_0_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.331561
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Up_bins-Up_bins_gaining_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE164505,GSE164506_3_v_2_indisulam_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217115_3_v_4_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23871
ACTR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60119
GSE211215_1_v_0_pemetrexed_human	RummaGEO Drug Perturbation Signatures	1.0	null
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
G6PC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.33403
GALNT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6785
PROM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54898
GSE131161_1_v_0_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ABT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54274
UF-43-HT41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288576
LTO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65354
ATP6V1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42236
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HEATR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21724
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.3
K562_MK-0752_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165558
CAVIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0627
TRAPPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43495
PDCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42721
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131649_4_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF148	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97339
CRAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01319
GSE169152_5_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF736	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18336
496100466_PCx_probable Alzheimer's disease_no TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.21027
GSE216394_2_v_0_pfkp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
USPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86245
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Congenital bilateral absence of vas deferens	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.79
PMC12673788-12967_2025_7484_MOESM5_ESM.xlsx-OCT4_cor_p_0_4-gene_id_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEx Muscle 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	5.82301
GSE131161_3_v_0_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Male infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.745
GSE200982_0_v_2_plac8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HMGN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14204
GSE60217_1_v_7_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9270251-mmc2.xlsx-4_Filtered_DEGs_Control_vs_KD_3-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152055_0_v_1_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HSPA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32775
GSE131649_4_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RUNDC3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06241
BLTP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38474
RC3H2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50779
BEST4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04169
GTEx Heart 20-29 vs 40-49	GTEx Tissue-Specific Aging Signatures	1.0	3.13941
Spermatogenic failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.127
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ATR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83225
PMC4595011-pgen.1005555.s001.xlsx-BPTF_UP-regulated-Ensembl_gene_id_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
chr2_97701308_C_A_b38	GTEx eQTL 2025	1.0	1.27839
K562_MK-5108_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151028
SNAI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11863
CAMSAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21629
GSE240439_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEx Thyroid 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	1.0	4.39899
K562_Nintedanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135219
VEGFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41822
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.54259
GSE182680,GSE182683_0_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28289
GSE157592_1_v_0_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HI-TOPK-032_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0137859
SLC26A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13492
GSE127790_4_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF470	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56621
CLDN19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29956
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE128240_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
COX14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67985
GSE169571_5_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE235066_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4909989-ncomms11840-s2.xlsx-up-regulate-The_YAP_TEAD4-FL_YAP_TEAD4-S_and_YAP_RBM4_regulated_genes_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE124932_2_v_1_sarm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
chr2_97703723_C_A_b38	GTEx eQTL 2025	1.0	2.72762
TUT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56784
RPL30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55468
GSE123861_1_v_0_sin3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100402_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.16651
VPS37A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24288
FKBP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02496
PITPNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14463
DUSP26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6928
GSE110676_0_v_4_mef2b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE191105_2_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RPP38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47311
Ralimetinib dimesylate_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0103858
NARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86605
RCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06661
ZNF501	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39039
MCM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46929
GSE203267_0_v_1_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
C1orf115	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64136
BICD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00187