association dataset threshold value standardized value SF767 CCLE Cell Line Gene CNV Profiles 1.0 1.70949 layer IIIa of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.69578 MDAMB453 CCLE Cell Line Gene CNV Profiles -1.0 -1.61188 SCRT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83542 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5468-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.09345 MAZ ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-34-5927-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZFAND2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.44225 Brain Lower Grade Glioma_LGG_TCGA-DU-8166-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Autosomal dominant nonsyndromic deafness DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.46 ventral medial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.963079 SG in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.24038 ATP11C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18733 hsa-miR-2054 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 Autosomal recessive nonsyndromic deafness 12 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.893 PLIN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57754 NCIH2085 CCLE Cell Line Gene CNV Profiles -1.0 -1.83465 KDM5A ENCODE Transcription Factor Targets 1.0 null Sarcoma_SARC_TCGA-IS-A3KA-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Autosomal genetic disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.541 EOLA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09615 C6orf226 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27733 NFIC JASPAR Predicted Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CE-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC6713698-109_2019_1809_MOESM2_ESM.xlsx-AR-PCOS-Gene_List_AR Rummagene Transcription Factor Associations 2026 1.0 null NSUN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90969 MTG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45037 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A69B-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12166 SP in midcingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.984905 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7058-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane part GO Cellular Component Annotations 2015 1.0 null 496100367_FWM_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.61635 PKN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83714 NOP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43024 NEIL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8532 ME-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.71298 Acute Myeloid Leukemia_LAML_TCGA-AB-2824-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EFO27 CCLE Cell Line Gene CNV Profiles 1.0 1.47719 SRSF4_02_04 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 3.85798 intrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null XPNPEP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81745 BLTP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17486 EOL1 CCLE Cell Line Gene CNV Profiles -1.0 -1.42578 Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A6C5-11A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CBX8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDQP1 CCLE Cell Line Gene CNV Profiles -1.0 -1.66966 POC1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51569 Lung adenocarcinoma_LUAD_TCGA-35-4122-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-185 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 AMFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93165 QPCTL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46157 cyclophosphamide_homo sapiens_gpl6244_gse42913 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-7580-11A-01R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RPS27A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22778 hsa-miR-4531 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 RMI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28648 SNU620 CCLE Cell Line Gene CNV Profiles 1.0 1.56681 TFRC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24084 SKMEL1 CCLE Cell Line Gene Expression Profiles -1.0 -2.90512 CARD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63588 Azoospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.031 CFPAC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11878 Brain Lower Grade Glioma_LGG_TCGA-TM-A84S-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TOR4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69423 WWTR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19063 SSBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71114 DNM1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81683 IQGAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88009 IZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.27681 THY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06086 external granular (germinal) layer of lower rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.29374 BICR18 CCLE Cell Line Gene CNV Profiles -1.0 -1.92703 NCI-H446 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11795 PPP3CA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99827 G120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.31402 Kidney Chromophobe_KICH_TCGA-KL-8324-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KYSE520 CCLE Cell Line Gene CNV Profiles -1.0 -2.17571 membrane LOCATE Predicted Protein Localization Annotations 1.0 null hsa-miR-449c TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 SKCO1 CCLE Cell Line Gene CNV Profiles 1.0 3.23673 GSU CCLE Cell Line Gene Expression Profiles 1.0 1.90311 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81S-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventral posterior inferior nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13913 DPF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03948 OE19 CCLE Cell Line Gene CNV Profiles 1.0 1.42893 Sarcoma_SARC_TCGA-DX-A8BK-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CPLANE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29269 PARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40971 Brain Lower Grade Glioma_LGG_TCGA-DU-7306-01A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4472 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FM-8000-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null C1R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1182 MICAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76119 ZNF670 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47766 PAFAH1B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82857 ZBTB24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53074 EFM-192B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.957672 TMEM70 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.678 YIPF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95901 GABPB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82939 ADM5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18578 SG in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.938755 EWS502 CCLE Cell Line Gene Expression Profiles 1.0 1.68141 NUDHL1 CCLE Cell Line Gene Expression Profiles 1.0 3.40805 deep layers of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19474 WNK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53765 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CA-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SUV39H2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85478 RAB29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51244 HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.889894 UCSD-242L Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00913 ZNF714 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10606 SAMD4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59913 SEC24C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15747 NOP14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82855 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SQ-A6I4-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HSPB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76502 outer plexiform zone in extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06248 olfactory part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.834494 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81W-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MICALL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2718 Lung adenocarcinoma_LUAD_TCGA-44-6778-01A-11R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MRPL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10517 Lung adenocarcinoma_LUAD_TCGA-97-7553-01A-21R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JN-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEP20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05398 BHY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.50375 Hypogonadotropic hypogonadism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.063 ZCCHC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16834 abducens nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.831526 hsa-miR-3685 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3466-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TRIM52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.85581 EPAS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03426 GTF3C3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38136 SP in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.12416 LDHD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57969 COX11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29694 hsa-miR-135b TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NUGC4 CCLE Cell Line Gene CNV Profiles 1.0 2.47581 CardiacMyocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -2.51056 MKN-74 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20407 ZNF582 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16346 ZNF419 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47005 ZNF750 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91298 MATN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7002 OlfactoryBulb BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.899305 PRKAG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18095 YPEL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89388 ME-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.64499 FAM110A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85716 C2CD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54406 P3H3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40424 DNASE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93324 SLC16A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09233 hsa-miR-765 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 PIP5KL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00767 inferior olive, medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.52138 MCUR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75065 SW403 CCLE Cell Line Gene Expression Profiles 1.0 1.85194 MZ in dorsomedial parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07445 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7250-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210476_9_v_5_rutaecarpine_human RummaGEO Drug Perturbation Signatures -1.0 null F36P CCLE Cell Line Gene Expression Profiles 1.0 1.65614 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5678-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RASGEF1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98537 CAL 27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.993813 KTN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91101 HMGCL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90213 Prostate adenocarcinoma_PRAD_TCGA-CH-5753-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.903916 MORCPR CCLE Cell Line Gene CNV Profiles 1.0 1.33842 CBX2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null APLNR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06341 TCTA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85352 ELF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85758 COLO 853 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.94601 PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_14_SALL4 Rummagene Transcription Factor Associations 2026 1.0 null USO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13832 UQCRQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78244 EEIG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42982 CP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.27916 HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00913 MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.95849 hsa-miR-4795-3p TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 PUM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01743 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6938-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null B3GNT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59135 DMS 79 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.21762 head and face region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.899253 Autosomal recessive nonsyndromic deafness DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.388 NCIH524 CCLE Cell Line Gene CNV Profiles -1.0 -1.51224 small intestine HPA Tissue Protein Expression Profiles 1.0 1.29863 superficial layers of caudal presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.18242 NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25651 HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.95733 KDM4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37368 Brain Lower Grade Glioma_LGG_TCGA-DU-5854-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QH-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VDAC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.9268 SG in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.76408 estradiol_homo sapiens_gpl570_gds3283 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CAR-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.60223 POGK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17246 hsa-miR-4328 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 ARSD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90967 ATOSB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20235 NT5DC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94291 HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02747 SPARC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43192 HSPA1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69775 KYSE-140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.841723 496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.44967 JURLMK1 CCLE Cell Line Gene CNV Profiles -1.0 -1.41442 TXNDC15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56768 Kidney Chromophobe_KICH_TCGA-KM-8476-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null REXO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63354 MEL-HO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.889894 YIF1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98854 CACTIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15517 ARL4C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56362 C17orf107 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27304 COX19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47285 SNU387 CCLE Cell Line Gene CNV Profiles 1.0 1.35799 LOXL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6972 HCC630 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.45325 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JF-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8096-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAB6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93003 Brain Lower Grade Glioma_LGG_TCGA-S9-A6WD-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Autosomal recessive nonsyndromic deafness 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.897 TOMM34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7393 SLC10A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42918 SUDHL4 CCLE Cell Line Gene Expression Profiles 1.0 2.13787 Lung squamous cell carcinoma_LUSC_TCGA-37-4130-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE139016_3_v_1_disulfiram_human RummaGEO Drug Perturbation Signatures 1.0 null Abdominal obesity-metabolic syndrome 1 DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.541 STT3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85154 GLIS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68257 Lymphoma_burkitts(Raji) BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.82703 hsa-miR-3140-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 AHR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8502 PCGF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87188 ZNF442 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17778 GSE212330_1_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null ZNF223 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90007 HT-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15997 FAAP24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92357 NCIH292 CCLE Cell Line Gene Expression Profiles -1.0 -1.7679 SW837 CCLE Cell Line Gene Expression Profiles 1.0 1.41069 KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF511 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66951 ABHD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5093 UQCRFS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.92574 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20027 MAGED2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.50345 Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A6SH-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-494 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 SG in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.878123 A1207 CCLE Cell Line Gene CNV Profiles 1.0 1.54915 Uterine Carcinosarcoma_UCS_TCGA-N7-A59B-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RETSAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97062 H2BW1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51563 Septic Shock_Whole blood_GSE9692 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.50864 PK-45P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.79891 PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_15_SALL4 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-626 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 Brain Lower Grade Glioma_LGG_TCGA-DU-6399-01A-12R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BICR 22 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.88715 NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.957672 SG in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.24878 HK2 CCLE Cell Line Gene CNV Profiles -1.0 -1.92635 HCC1438 CCLE Cell Line Gene Expression Profiles 1.0 1.5541 SP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.21778 SHMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15462 Kidney renal clear cell carcinoma_KIRC_TCGA-B2-5639-01A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAPKAPK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26128 KYSE-520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.25207 NCIH2228 CCLE Cell Line Gene CNV Profiles 1.0 1.72521 BICR 78 Klijn et al., Nat. 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Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.841723 caudal prosubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.21079 Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VX-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WNT5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00829 EBF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92505 PTBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34031 NTMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97162 ELK4 JASPAR Predicted Transcription Factor Targets 1.0 null ZNF763 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91784 DU 145 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.80224 KDM5C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29246 Rectum adenocarcinoma_READ_TCGA-EI-6511-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.903944 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7183-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2J6-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FTH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01361 SNX8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88386 COLO 320DM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.862456 NELFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.18391 TTYH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8048 PSMC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61534 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6V1-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CD177 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56563 hsa-miR-3194-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 hsa-miR-590-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 NUP42 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60224 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4759-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PIK3R4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99065 KRI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15389 FTO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49873 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7261-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39085 PANC0213 CCLE Cell Line Gene CNV Profiles 1.0 1.69178 PMC11258892-NIHMS2003533-supplement-MMC6.pdf-48-ZNF229_ZNF229 Rummagene Transcription Factor Associations 2026 1.0 null ES-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.940908 ZFYVE16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34811 BV173 CCLE Cell Line Gene CNV Profiles -1.0 -1.33563 RPN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69344 IGR39 CCLE Cell Line Gene CNV Profiles 1.0 1.77646 KPNA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10501 HNF4A JASPAR Predicted Transcription Factor Targets 1.0 null TDRD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44102 dorsorostral division of MFC (area 32) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.0537 INPP5K CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13974 hsa-miR-3942-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80O-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AJM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83821 Brain Lower Grade Glioma_LGG_TCGA-TM-A84H-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ALX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.689 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 Breast Cancer_Mammary Gland Tissue_GSE3744 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.45909 TRAM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69222 hsa-miR-4659a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 ZDHHC24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43499 ZFP36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.55769 SLC35B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43157 H1-6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17819 SORD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86667 Brain Lower Grade Glioma_LGG_TCGA-WY-A85A-01A-21R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POU4F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.38693 F36P CCLE Cell Line Gene CNV Profiles -1.0 -1.33699 BC3C CCLE Cell Line Gene CNV Profiles 1.0 1.51978 TE125T CCLE Cell Line Gene Expression Profiles -1.0 -1.86452 DLG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88401 caudal (posterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04961 TAS2R5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88722 STOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64437 RMG-I Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16258 AZI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3671 Lung adenocarcinoma_LUAD_TCGA-55-7815-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RNF17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63489 NDUFAF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63265 PCSK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98768 SNU503 CCLE Cell Line Gene CNV Profiles -1.0 -1.57486 LXF-289 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.95733 retina BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.845808 PWWP3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64425 RAB12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38822 ZNF831 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65867 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A460-01A-21R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BACH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6649 19377508-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-5R-AA1D-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-2A-A8VL-01A-21R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-62-A46U-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UMPS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76695 ZNF70 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80549 TPM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66498 ME-180 COSMIC Cell Line Gene CNV Profiles 1.0 4.51153 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6225-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ALPK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75942 deep layers of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.945003 rostral division of OFCi (area 11) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 3.34509 DDX31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36069 MESP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13206 JADE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27103 TMEM139 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0277 spleen GTEx Tissue Gene Expression Profiles 1.0 0.934779 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RM-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Syndrome DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.541 PTP4A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26814 INTS12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25995 GFM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94978 NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.84952 KIAA1191 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.27531 Adrenocortical carcinoma_ACC_TCGA-OR-A5JJ-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CBLL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2743 Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HF-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RUVBL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48033 GNAZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50973 FAM98A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.18569 KMS18 CCLE Cell Line Gene Expression Profiles 1.0 2.04754 duodenum HPA Tissue Protein Expression Profiles 1.0 1.29863 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45R-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ESYT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59523 membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 hsa-miR-135a TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 PCNX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5468 NCI-H1666 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.889894 CDK2AP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48942 CARMIL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51432 CHD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36837 Lung adenocarcinoma_LUAD_TCGA-75-6211-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ACER2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3475 layer VI of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10683 TE8 CCLE Cell Line Gene CNV Profiles 1.0 1.53091 Brain Lower Grade Glioma_LGG_TCGA-HT-7477-01B-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null GSE196117_6_v_0_clarithromycin_human RummaGEO Drug Perturbation Signatures 1.0 null PEX16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55428 Liver BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.23407 G96 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02747 Lung adenocarcinoma_LUAD_TCGA-MP-A5C7-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4417 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 EML4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3767 ZNF814 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30862 Lassa Fever Virus_8hr_24069471_GSE41300 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.7957 hsa-miR-4536 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 MPZL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.388 REV1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68429 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7406-11A-01R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1IB-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-DX-A23R-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ICE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.43479 Spermatogenic failure DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.32 FAM72B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71919 outer SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.878092 FAM50A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84378 SNU489 CCLE Cell Line Gene CNV Profiles 1.0 1.45162 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1HV-06A-21R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MGAT5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65239 PIK3R2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86333 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A8P1-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73998 layer V of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.88963 Sarcoma_SARC_TCGA-3B-A9HJ-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer III of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.14725 Lung adenocarcinoma_LUAD_TCGA-05-4397-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SCC15 CCLE Cell Line Gene CNV Profiles 1.0 1.39515 EOMES CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51252 MEC2 CCLE Cell Line Gene Expression Profiles 1.0 2.56733 Pancreatic adenocarcinoma_PAAD_TCGA-FB-A7DR-01A-21R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MEWO CCLE Cell Line Gene CNV Profiles -1.0 -1.47464 WASF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57667 RCC4 CCLE Cell Line Gene Expression Profiles -1.0 -1.7489 SLU7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10788 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51H-06A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEP170B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04892 MRPS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4796 CAL27 CCLE Cell Line Gene CNV Profiles 1.0 1.68391 STIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40785 FHOD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37771 RBM15_02_87 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 3.64386 HPS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2878 molecular layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.980479 Lung squamous cell carcinoma_LUSC_TCGA-22-A5C4-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BCPAP CCLE Cell Line Gene Expression Profiles 1.0 1.40342 Head and Neck squamous cell carcinoma_HNSC_TCGA-CX-7082-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PIGC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26374 Brain Lower Grade Glioma_LGG_TCGA-S9-A7R3-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RABEP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06203 MICU2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81631 TRERF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.673 hsa-miR-3682-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 ZXDB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3922 BARHL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43048 E2F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71752 OCI-LY-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.89096 Kidney renal clear cell carcinoma_KIRC_TCGA-AS-3777-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IMPACT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91616 MFM-223 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25651 MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null PCDHB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92823 EIF4H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66148 Abdominal obesity-metabolic syndrome DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.541 SW1116 CCLE Cell Line Gene CNV Profiles -1.0 -2.08236 NCI-H522 Klijn et al., Nat. 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Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.50375 TTC30A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27043 inner CP in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.12276 Brain Lower Grade Glioma_LGG_TCGA-HT-7874-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100466_PCx_probable Alzheimer's disease_no TBI_89_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.1356 SLC11A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49003 HOS CCLE Cell Line Gene CNV Profiles 1.0 1.79618 VZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.56815 DB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05888 FAN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45107 CDC42BPG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81017 stratum pyramidale of rostral CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.22766 RFWD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39708 hsa-miR-4447 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ZNF492 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43989 MCRS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99814 TRIM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89866 GPR160 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82315 SK-BR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.846946 hsa-miR-1261 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 ATP5MF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26872 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A49A-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A431-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Autosomal recessive nonsyndromic deafness 23 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.138 SP in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07134 cellular_component GO Cellular Component Annotations 2015 1.0 null integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A4-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Gene_Name_MIXL1 Rummagene Transcription Factor Associations 2026 1.0 null MCTS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80843 RMDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.80291 DLGAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43227 SPTAN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8119 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QF-01A-12R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NEUROD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01735 Autosomal recessive nonsyndromic deafness 21 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.176 GSE174701_5_v_2_maml3_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF718 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29376 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6491-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.89096 MX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10214 B4GAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67524 PRDX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54056 RGS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03144 RFXAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47476 C2BBE1 CCLE Cell Line Gene CNV Profiles -1.0 -2.59435 NCI-H2803 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.31396 KIAA1522 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94048 Prostate adenocarcinoma_PRAD_TCGA-M7-A720-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KE97 CCLE Cell Line Gene Expression Profiles 1.0 1.75484 CAPRIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06757 CSRNP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99177 PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Nearest_Ensembl_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null TRIM35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32561 ZNF611 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27981 Lung adenocarcinoma_LUAD_TCGA-95-7947-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-DX-A3LY-01B-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A685-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MUTYH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57891 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81E-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Thymus BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.941733 hsa-miR-571 TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 Brain Lower Grade Glioma_LGG_TCGA-DU-5871-01A-12R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF664 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47219 EHBP1L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71285 Pancreatic adenocarcinoma_PAAD_TCGA-IB-7889-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.32207 GR-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.50375 rostral (anterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.20568 Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-223 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GSE235066_4_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16923 WDR45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49866 Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HA-01B-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TUT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15192 KYO1 CCLE Cell Line Gene Expression Profiles 1.0 1.40653 RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.841723 levodopa_rattus norvegicus_gpl4135_gse43375 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 496100543_FWM_probable Alzheimer's disease_TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.25383 NCIH1793 CCLE Cell Line Gene CNV Profiles 1.0 1.81052 inner portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.973011 MED28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69324 hsa-miR-3919 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 DU4475 CCLE Cell Line Gene Expression Profiles 1.0 1.51838 Brain Lower Grade Glioma_LGG_TCGA-S9-A7R7-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF331 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86301 posterior hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.9516 HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.891502 VZ in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19191 NUGC2 CCLE Cell Line Gene CNV Profiles 1.0 1.4693 Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYOCD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3963 LARP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45171 layer III of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.945125 OVOL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08697 HMC18 CCLE Cell Line Gene Expression Profiles 1.0 1.47664 outer CP in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.50157 CFPAC1 CCLE Cell Line Gene Expression Profiles -1.0 -1.51746 KYSE-270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12166 EGR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87676 HT55 CCLE Cell Line Gene Expression Profiles 1.0 1.39833 FSTL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08894 JVM3 CCLE Cell Line Gene Expression Profiles 1.0 1.7998 SNU5 CCLE Cell Line Gene Expression Profiles 1.0 1.45996 Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M5-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF573 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02291 DCUN1D5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82637 hsa-miR-4476 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 Lung adenocarcinoma_LUAD_TCGA-91-8497-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EXO5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.79295 HEY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.924585 ME1 CCLE Cell Line Gene CNV Profiles -1.0 -1.61502 ENO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.08569 intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 gonad TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Autosomal dominant disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.541 SP in entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.30777 EFO-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.55403 hsa-miR-432 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 hsa-miR-1256 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 TBC1D16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32665 MICOS13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90259 SMIM10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76027 UBA52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03659 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7255-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UBE2D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71303 Lung adenocarcinoma_LUAD_TCGA-49-6742-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CDCA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67777 liver GTEx Tissue Gene Expression Profiles 1.0 1.14098 MRTFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94999 Brain Lower Grade Glioma_LGG_TCGA-HT-7478-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FMNL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1481 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A6L9-06A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5890-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null GSE212330_1_v_0_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null EMC7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77019 CTSL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23393 KNS42 CCLE Cell Line Gene CNV Profiles 1.0 1.89135 RASL11A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86942 GNB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71648 Kidney Chromophobe_KICH_TCGA-KN-8419-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EPCAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40051 IQGAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46925 ETHE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.27391 PUS7L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8546 testis TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MRPS26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98974 IFITM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6632 GNPTAB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64582 TSNAX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8543 ZNF235 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43123 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6907-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EPN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20435 PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-645-ENSG00000274349_ZNF658 Rummagene Transcription Factor Associations 2026 1.0 null MTMR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62397 MHH-ES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15997 SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.95849 NAA60 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49021 RABL2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25272 FUT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71531 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5VV-06A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-91-6829-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23902 hsa-miR-3173-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53496 ZNF320 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88534 Heart BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.48643 MTHFD1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69258 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I5-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null G-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.95733 OSBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43868 NEU1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5921 TOLLIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19026 Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.541 APOBEC3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30235 PNMA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37753 ZNF76 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99499 EMC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59131 CD74 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36201 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6994-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NUPR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57271 ZNF623 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54483 hsa-miR-1827 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1MF-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100567_PCx_no dementia_TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.18833 HTRA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.507 RAB17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93004 HSPA14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06774 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4712-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99433 RBM15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19595 IQGAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53631 DDIAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06449 NKX2-5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77096 CTCFL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7947 PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_1h-Nearest_Ensembl_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null BICR16 CCLE Cell Line Gene CNV Profiles 1.0 1.37369 Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WM-01A-12R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STAT3 JASPAR Predicted Transcription Factor Targets 1.0 null hsa-miR-4727-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 Autosomal recessive nonsyndromic deafness 9 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.867 RARG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98139 TMPO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.20752 NDUFA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01001 SG in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.971013 Kidney Chromophobe_KICH_TCGA-KN-8430-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SUMO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46197 CDCA8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38089 KMS-12-PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18499 outer portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.60164 SKM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.46749 MKN-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00913 SNU-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.82455 Lung adenocarcinoma_LUAD_TCGA-55-7724-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AMIGO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08253 Lung adenocarcinoma_LUAD_TCGA-05-4422-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4761-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 ZNF347 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93872 Sarcoma_SARC_TCGA-HB-A5W3-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE139455_0_v_3_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00913 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70K-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COLO 699 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00913 Acute Myeloid Leukemia_LAML_TCGA-AB-2929-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1 Rummagene Transcription Factor Associations 2026 1.0 null CKB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29233 MPV17L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67019 CORO1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75024 GSE210476_9_v_7_rutaecarpine_human RummaGEO Drug Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-55-6983-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GNB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36761 VPS51 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11802 IRF1-21803131-MONOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3689d TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 BAX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21362 Prostate adenocarcinoma_PRAD_TCGA-V1-A8WV-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SU8686 CCLE Cell Line Gene Expression Profiles 1.0 1.97139 PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-196-ZNF658_ZNF658 Rummagene Transcription Factor Associations 2026 1.0 null DVL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13396 inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.16159 YY1 JASPAR Predicted Transcription Factor Targets 1.0 null KELLY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.69802 LIN7C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69326 ZNF23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96848 Kidney Chromophobe_KICH_TCGA-KN-8418-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4330 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 ZMYND8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05058 SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.959174 medial subdivision of central nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.27252 MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02747 PRPSAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4474 Rectum adenocarcinoma_READ_TCGA-G5-6235-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-298 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 CEP164 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.93729 ARL6IP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6275 CHCHD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40937 HS616T CCLE Cell Line Gene Expression Profiles -1.0 -1.81692 BCL2L10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84519 CMTM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75634 hsa-miR-3545-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 PEX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.33031 SNU1076 CCLE Cell Line Gene CNV Profiles 1.0 2.0092 Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T8-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STK31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2712 SETD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75208 496100386_PCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.85334 SUPT4H1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94423 ZFHX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53867 WRAP73 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49276 PJA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30598 VZ in septal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.92772 KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.891502 Brain Lower Grade Glioma_LGG_TCGA-S9-A7J0-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHRAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3421 NOTCH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61052 H3K27me3_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRMS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54682 PIGU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48871 SNAI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35967 Enterovirus 71_4Hour_None_GSE15323 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.29265 NFYC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22722 H2AX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96163 Brain Lower Grade Glioma_LGG_TCGA-TM-A7CF-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null G44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.098 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4224-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OPM2 CCLE Cell Line Gene Expression Profiles 1.0 1.47586 KYSE-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16923 plasma membrane LOCATE Predicted Protein Localization Annotations 1.0 null ZNF44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79497 K-562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00913 A-VN-1203-2004(H5N1)_Day4-10^2pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.05757 Head and Neck squamous cell carcinoma_HNSC_TCGA-RS-A6TO-01A-32R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LUC7L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01096 Lung squamous cell carcinoma_LUSC_TCGA-43-7658-11A-01R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null retroparafascicular area of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.107 membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PPP2R5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.13519 Skin Cutaneous Melanoma_SKCM_TCGA-FR-A69P-06A-21R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2891-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AICDA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9433 GlobusPallidus BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.943648 SNX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27103 NCI-H1792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20392 LRP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19588 SW1990 CCLE Cell Line Gene CNV Profiles -1.0 -1.78315 ZNF865 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99835 Monogenic disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.541 Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5835-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SF3A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86295 internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null U2AF1_02_97 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 3.45943 PLA2G15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14335 Ovary BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.84309 SG in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.13227 Acute Myeloid Leukemia_LAML_TCGA-AB-2975-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU216 CCLE Cell Line Gene CNV Profiles 1.0 1.46107 Adrenocortical carcinoma_ACC_TCGA-PK-A5HB-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CBX8 ENCODE Transcription Factor Targets 1.0 null KELLY CCLE Cell Line Gene CNV Profiles -1.0 -1.33351 LIN37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35285 MLF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53728 ZRANB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28949 NDUFB7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47722 YBEY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6745 CUL7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44457 Brain Lower Grade Glioma_LGG_TCGA-HT-8018-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GRPR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51217 TM31 CCLE Cell Line Gene CNV Profiles 1.0 1.36071 SLC6A8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62969 IALM CCLE Cell Line Gene CNV Profiles -1.0 -1.67937 DPP7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6784 PLEKHF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9401 PTK7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95954 BRD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.55349 PPP1R1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10454 RBM18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60138 PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Down_bins-Down_bins_loosing_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null VZ in midcingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.837858 TMEM258 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29118 A1CF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82003 TTPAL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61453 AURKC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49954 NAAA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45583 DDX49 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57867 outer CP in caudal cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.873686 ESRRB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.41459 endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null TM7SF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76279 Lung adenocarcinoma_LUAD_TCGA-55-6980-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FASTKD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60978 MSH4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73552 integral component of membrane GO Cellular Component Annotations 2015 1.0 null IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.20962 AGMAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66048 hsa-miR-1248 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 CXCL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76537 LN443 CCLE Cell Line Gene Expression Profiles -1.0 -2.0228 subgenual (subcallosal) division of MFC (area 25) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.16939 NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.098 Rectum adenocarcinoma_READ_TCGA-AF-4110-01A-02R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KO52 CCLE Cell Line Gene CNV Profiles -1.0 -1.80132 MDS - Myelodysplastic syndrome_Bone marrow stem cell_GSE4619 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.61938 Brain Lower Grade Glioma_LGG_TCGA-DU-5872-02A-21R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5460-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PIM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75782 496100564_TCx_no dementia_no TBI_82_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.05308 MTARC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92453 Autosomal recessive nonsyndromic deafness 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.918 SERPINE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41446 SOX17_01_300 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.63934 HNRNPH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29038 Acute Myeloid Leukemia_LAML_TCGA-AB-2917-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TNFRSF1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.14386 PAGE4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45006 Brain Lower Grade Glioma_LGG_TCGA-S9-A89Z-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-97-A4M2-01A-12R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer II of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.19785 ZNF618 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.264 layer V of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.2458 COQ6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9681 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JK-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Rectum adenocarcinoma_READ_TCGA-AF-6655-01A-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WSB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42762 SK-MEL-31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26775 Uterine Carcinosarcoma_UCS_TCGA-N8-A4PI-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null stratum radiatum of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.44054 HCC1599 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.80024 PHOSPHO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9306 SG in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.0905 ADI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70991 CACO2 CCLE Cell Line Gene CNV Profiles -1.0 -2.35126 MTMR14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87476 hsa-miR-1182 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 hsa-miR-3973 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NCI-H2228 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18499 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.960233 MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-21-5782-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-1273g TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 ACOT8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07038 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7395-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RASSF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01859 LIN28A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60968 RNF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69054 ADD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.61691 MEF2A JASPAR Predicted Transcription Factor Targets 1.0 null PSPH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88854 PMC9380317-13045_2022_1327_MOESM3_ESM.xlsx-Table_S7-Table_S7_Top_500_differentially_modified_gene_bodies_between_MM_and_its_precursors_in_AA_patients_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null POTEE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14004 TIGD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15069 RNF2 ENCODE Transcription Factor Targets 1.0 null SDC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36863 Sarcoma_SARC_TCGA-QQ-A5VD-01A-21R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.902667 TPM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71709 SLC25A27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90897 Adrenocortical carcinoma_ACC_TCGA-OR-A5LE-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8175 HPS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13422 PrefrontalCortex BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.99471 inferior nucleus of pulvinar Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08536 hsa-miR-4659b-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 ZNF776 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71584 CAL851 CCLE Cell Line Gene Expression Profiles -1.0 -1.67326 SLC36A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46821 Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.61384 JHH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.957672 Acute Myeloid Leukemia_LAML_TCGA-AB-2903-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBL1Y CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53468 IRF1 ChEA Transcription Factor Targets 1.0 null GLUD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77879 496100547_HIP_no dementia_no TBI_82_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.60767 HS840T CCLE Cell Line Gene Expression Profiles -1.0 -2.05395 MPZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65865 CMK86 CCLE Cell Line Gene CNV Profiles -1.0 -1.48034 CCDC59 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83665 cell part LOCATE Predicted Protein Localization Annotations 1.0 null PDCD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00549 RCBTB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49272 496100397_PCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.24038 DAUDI CCLE Cell Line Gene Expression Profiles 1.0 2.45641 UNC93B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11127 pancreas GTEx Tissue Gene Expression Profiles -1.0 -1.07654 CMK115 CCLE Cell Line Gene CNV Profiles -1.0 -1.36822 VZ in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.875641 RABL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74282 HADHA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67398 EDRF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84817 RHBDF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5291 Autosomal recessive nonsyndromic deafness 4 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.849 NCI-H2452 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.21762 PRAME CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09836 AMOTL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01355 BCLAF1_01_214 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.28009 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6020-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ABCA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2641 Lung adenocarcinoma_LUAD_TCGA-50-5930-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Psoriasis vulgaris_Skin tissue_GSE14905 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.67135 Skin Cutaneous Melanoma_SKCM_TCGA-GF-A6C9-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-4A-A93X-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GPR75 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65059 GPR153 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82721 ZNF343 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92054 MEWO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.6214 H2BC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32958 intermediate portion of DFC (area 9/46) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.04996 ZNF764 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26413 TFAP2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39085 Lung adenocarcinoma_LUAD_TCGA-50-5939-11A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GNAI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21415 AKT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86097 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3387-01A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MEC1 CCLE Cell Line Gene Expression Profiles 1.0 2.25243 UACC-257 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25651 KSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.36967 Brain Lower Grade Glioma_LGG_TCGA-P5-A5EX-01A-12R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-488 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 OVCAR4 CCLE Cell Line Gene Expression Profiles -1.0 -2.14271 496100544_PCx_no dementia_no TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.20712 TST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67769 DCAF12L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05593 MDA-MB-453 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.69881 SKRC31 CCLE Cell Line Gene Expression Profiles -1.0 -1.58503 Lymphoma_burkitts(Daudi) BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.84085 Acute Myeloid Leukemia_LAML_TCGA-AB-2973-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-QH-A65V-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SHPK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59092 rostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.32885 hsa-miR-1245b-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 spinal (inferior) vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.948029 PLK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63463 TM9SF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84777 EPHB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40773 NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02382 SOX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10088 ZNF514 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.969 CYYR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.18977 fallopian tube GTEx Tissue Gene Expression Profiles -1.0 -2.10021 gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null hsa-miR-4471 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 GSE234155_7_v_1_nfix_human RummaGEO Gene Perturbation Signatures -1.0 null Sarcoma_SARC_TCGA-FX-A3NJ-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SRSF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47866 TMF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3159 PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Nearest_Ensembl_MIXL1 Rummagene Transcription Factor Associations 2026 1.0 null TT CCLE Cell Line Gene Expression Profiles 1.0 1.38697 MNT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39309 GNRH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66869 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YU-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HS606T CCLE Cell Line Gene Expression Profiles -1.0 -1.52604 NOLC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81065 ELMOD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50092 U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.77971 CCNA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.76399 Uterine Carcinosarcoma_UCS_TCGA-ND-A4WC-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TM-A84F-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GA10 CCLE Cell Line Gene Expression Profiles 1.0 1.5917 MGMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00767 Lung adenocarcinoma_LUAD_TCGA-97-7941-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VHL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70521 YTHDF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77265 OCI-LY-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15997 AKR1A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28876 RFK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92001 Huntington's Disease_Lymphocyte_GSE8762 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.97306 male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null TP53I13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56761 hsa-miR-4723-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 UBE2L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41699 SW 1116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.18688 gigantocellular reticular nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02013 Skin Cutaneous Melanoma_SKCM_TCGA-RP-A6K9-06A-41R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A6TW-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-A4SS-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NUGC-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.882751 ZNF33B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01079 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4338-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05968 KRTCAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36368 H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ARHGDIG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65534 SHISA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4056 RFLNB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8933 PPP2R5D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32861 NCOA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59186 NR0B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7851 COR-L279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26775 WWC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78146 SNU46 CCLE Cell Line Gene Expression Profiles -1.0 -3.20729 IL18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21692 Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3JX-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100529_HIP_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.13434 hsa-miR-3622b-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 AP4B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83632 FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null RNF2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW 1990 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.15102 CC2D1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61403 SCC-25 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.33124 PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TM-A7CA-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inner CP in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.947043 PRELID3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11171 CILK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.82461 HOXB13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94011 NOMO1 CCLE Cell Line Gene CNV Profiles -1.0 -1.58158 inner CP in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.901906 SLC7A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33131 RERE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21655 GRIN3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8276 Head and Neck squamous cell carcinoma_HNSC_TCGA-TN-A7HI-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4728-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CLDN19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29956 MKN-45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.43216 PC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.890715 CUL4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.45047 Brain Lower Grade Glioma_LGG_TCGA-HT-7606-01A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H4C16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93741 STEAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3331 hsa-miR-489 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 SQ1 CCLE Cell Line Gene CNV Profiles -1.0 -3.21039 polymorphic layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.03363 RILPL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21253 MELK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56256 POLR3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10486 LN340 CCLE Cell Line Gene Expression Profiles -1.0 -2.29988 MZ in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.99294 SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.4184 Kidney Chromophobe_KICH_TCGA-KM-8639-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RGS14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.97119 EPOR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96372 COLO 857 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01367 NCI-H2009 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.944947 LOX-IMVI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.889894 S1PR5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35939 DTWD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72602 GSE129241_1_v_0_valproic acid_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3367-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH1435 CCLE Cell Line Gene Expression Profiles 1.0 1.6856 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51J-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RNF146 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71855 MITF ChEA Transcription Factor Targets 1.0 null INKA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84452 outer SZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.62722 parasubicular cortex (parasubiculum) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.70626 UBE2I CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58814 SHARPIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50295 Brain Lower Grade Glioma_LGG_TCGA-S9-A6WP-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Primary ciliary dyskinesia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.2 ASB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43285 Epidermodysplasia verruciformis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.545 lower limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.985958 ELF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11084 MYBL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79108 blood GTEx Tissue Gene Expression Profiles 1.0 1.22369 hsa-miR-4795-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 CBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23501 NCBP2AS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5464 PIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66409 hsa-miR-4446-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 Rectum adenocarcinoma_READ_TCGA-DY-A1DF-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Down Syndrome_Fetus_GSE10758 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.81471 NB1 CCLE Cell Line Gene Expression Profiles -1.0 -1.78614 C6orf120 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39932 caudal subdivision of medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.41904 SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20027 SLC29A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49876 SLC38A10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96081 ADCY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70764 TAF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33434 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null N4BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34813 Rectum adenocarcinoma_READ_TCGA-AG-4022-01A-01R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.28196 P3H4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73438 HTK CCLE Cell Line Gene Expression Profiles -1.0 -1.76852 SEPHS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54732 PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Gene_Name_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null CBX2 ENCODE Transcription Factor Targets 1.0 null PCSK9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37141 ARFIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.94123 ALDH5A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.11022 GTL-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00913 hsa-miR-4729 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 Lung squamous cell carcinoma_LUSC_TCGA-58-8386-01A-11R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MOR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.05969 GLIS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72783 HGC27 CCLE Cell Line Gene CNV Profiles 1.0 1.47279 ARPC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47449 PHF21B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.13066 ATF7IP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03589 Acute Myeloid Leukemia_LAML_TCGA-AB-2855-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TMEM37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34728 496100362_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.3828 CACO-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -3.44563