association	dataset	threshold value	standardized value
UBTF	ENCODE Transcription Factor Targets	1.0	null
placenta	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067935
Perturb_1187_KD_BCL6_SRP187038	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.9121
GSE210101,GSE210114_2_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Specific developmental disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.89
GSE198165,GSE198166_5_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TNIK_knockdown_297_GSE17623	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.70405
primary auditory cortex (core)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.8611
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.97747
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DOK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07369
BRD-K74391203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02004
Lung adenocarcinoma_LUAD_TCGA-55-6968-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Schizoid personality disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
GSE210101,GSE210114_8_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.91164
BRD-K61791241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.78118
deferoxamine-460	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Uterus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.15988
Glomerular layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.848
phenazopyridine-6100	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Sleep duration (short sleep)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.752288
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE210870_0_v_2_snai1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BC-54-ON71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.345549
SNU878	CCLE Cell Line Gene CNV Profiles	1.0	1.34019
Sox1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.3384
SARS-CoV MA15_Day7-PFU-10^4_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.86763
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.83445
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Perturb_4292_KO_Nkx3.1_SRP374413	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
nucleoside binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-X4XX-0011-R8B-SM-46MWM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.064
BRD-K89537738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65243
eye	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN015_HEPG2_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.34083
hsa-miR-4512	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.908471
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4860-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of the intestine	GWASdb SNP-Phenotype Associations	1.0	0.218531
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.18534
GTEX-R55E-0011-R4A-SM-2TC5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16079
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.59644
Kidney renal papillary cell carcinoma_KIRP_TCGA-KV-A74V-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K73296134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18533
SKNDZ	CCLE Cell Line Gene Expression Profiles	1.0	1.44638
H3K27me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K04441230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2431
PANC0813	DepMap CRISPR Gene Dependency	1.0	2.20685
tanespimycin-505	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_4144_KO_Bcl11a/Bcl11b_SRP334609	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GTEX-NPJ8-0011-R6a-SM-2HMKB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78878
SubthalamicNucleus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.15736
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF682	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.1645
BRD-K14499901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7271
GSE261563_9_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WWYW-0011-R7A-SM-3NB3H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08973
A673	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47932
Infralimbic cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.583
Deutocerebrum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.15
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitotic fetal germ cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
primary auditory cortex (core)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0367
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.979829
ZFP281-18757296-E14-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41821
Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J7-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE249714_0_v_1_anxa1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Ovary	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-3.2197
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K86631750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13237
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-M88324697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05196
HCC1569	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.35996
CRCGN012_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.89392
COLO-320-HSR	GDSC Cell Line Gene Expression Profiles	1.0	1.58946
PMC5105166-ncomms13331-s11.xlsx-Sheet1-Supplementary_Data_10_Overlap_of_upregulated_genes_in_MEF2D-rearranged_cases_with_public_ChIPseq_RNAseq_data_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
AE-97-TS20_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.358716
RPL19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07444
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TC-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QVUS-0011-R6A-SM-3GACX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07719
GSE195559_6_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.29515
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
H4K20me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K41814083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27688
mRNA_MEF2C_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
OXSM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65849
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
adrenal gland	HPA Tissue Protein Expression Profiles	1.0	1.47108
Fetalbrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.59981
GSE140651,GSE140653_5_v_7_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126127_0_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.202009
Acute Myeloid Leukemia_LAML_TCGA-AB-2848-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NH12	DepMap CRISPR Gene Dependency	1.0	3.46997
BRD-K43789905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09331
GSE217363_4_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE190316,GSE190324_1_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
REST_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BE-28-WW67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205679
VZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.960756
SNU840	CCLE Cell Line Gene Expression Profiles	-1.0	-3.35774
KE-37-MN32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.506949
NEU	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.968
spinal cord	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MAPK15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20284
SP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	111.83
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15965
stomach	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.868012
GSE216043_11_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TE8	CCLE Cell Line Gene Expression Profiles	-1.0	-2.41134
GSE192663_1_v_5_acly_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
binding	GO Molecular Function Annotations 2015	1.0	null
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K71184289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75184
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DD-43-WW40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215624
NAMALWA	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3643
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.612152
Perturb_6515_KD_PDXP_SRP106855	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.1019
GSE241701_4_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08109
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.11922
GTEX-X261-0011-R10B-SM-4E3JT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907801
Psoriasis vulgaris_Skin tissue_GSE14905	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.2644
GSE160817_5_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE109140_2_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-107	TargetScan Predicted Conserved microRNA Targets	1.0	0.159923
glial cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.903655
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6919
H3K27me3_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_Panc1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Renal glycosuria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
639V	CCLE Cell Line Gene CNV Profiles	1.0	1.63146
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TAL1_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
purine ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
ECC10	CCLE Cell Line Gene Expression Profiles	1.0	1.70902
TRIM28-19339689-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K13898728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41729
NB17	GDSC Cell Line Gene Expression Profiles	1.0	1.5087
GSE207611,GSE207612_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K67525206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01445
JUND	ENCODE Transcription Factor Targets	1.0	null
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25367
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67V-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inner CP in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.844034
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.46926
PMC10111863-supp_gad.350269.122_Supplemental_Paun350269_FileS3.xlsx-A_ASCL1-regulated_DGE-geneID_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cranial ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.33156
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X261-0011-R5A-SM-3NMB4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856316
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GSE205163,GSE205164_3_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
MB1	DepMap CRISPR Gene Dependency	1.0	2.5644
BRD-K29200961	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06993
GSE195568_1_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
OVCAR-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.086
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.10856
TMBIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06494
GSE126345_11_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
REST_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CC-68-YZ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.5955
ANKRA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16513
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bupropion-3180	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE131588,GSE131690_1_v_0_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF7	ENCODE Transcription Factor Targets	1.0	null
GTEX-NPJ8-1526-SM-2D7VU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19325
BRD-K93374700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61457
PMC11330984-41467_2024_51229_MOESM6_ESM.xlsx-MYC_UP-ID_ENSEMBL_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
lobelanidine-5500	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.72248
15982419-Table1	GeneSigDB Published Gene Signatures	1.0	null
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
abnormality of the abdominal organs	GWASdb SNP-Phenotype Associations	1.0	0.065991
GTEX-QMR6-0011-R1A-SM-32PKW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.889702
REST_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201239_3_v_4_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.962668
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03549
GALNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44206
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SNU-407	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EXOC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04491
hippocampus (hippocampal formation)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.8611
KIF20B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12709
BRD-K66253165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73539
GTEX-WZTO-2926-SM-3NM9I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44227
Sox3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.3809
Perturb_15487_KD_SMARCA4_SRP218853	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.2293
LN319	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.25135
TCF3-18347094-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-X585-0011-R4B-SM-46MVH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.94486
OCT4-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.85983
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23205
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.09778
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9024
CRCGN015_MCF10A_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.3376
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MKN28	GDSC Cell Line Gene Expression Profiles	-1.0	-1.48324
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A465-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K64698855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69777
mesalazine-6162	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.14972
H2BC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50085
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVJO-1426-SM-2S1QY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33415
GSE175787_4_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
PTPN23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23539
outer CP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.852117
GSE211983_1_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cell culture	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.075613
BRD-K64730761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02151
GSE164757,GSE164759_4_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
tetraethylenepentamine-412	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.931291
Household income (MTAG)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	3.1
BRD-K72278003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.81143
PCI-6A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MALME 3M	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.855726
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SN-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K36736230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27625
GSE190316,GSE190324_6_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.72573
SC-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.06899
CRCGN017_MCF10A.WT.HP_24H:N22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1291
CRCGN015_MCF10A.TP53.M_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.8723
PMC9894241-pnas.2211429119.sd05.xlsx-G1_REST-Dataset_S5_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
COR-L279	GDSC Cell Line Gene Expression Profiles	1.0	1.73487
H3K27me3_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE189609_1_v_0_hax1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SK-MEL-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.32135
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44026
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.441426
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
GATA3_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fibroblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.219264
upper (rostral) rhombic lip_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05738
DERL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48149
H4K91ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Extremely high intelligence	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.739794
BRD-A00680357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04997
Reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
GTEX-T2IS-0011-R6A-SM-32QP2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71602
PMC12198403-41398_2025_3437_MOESM1_ESM.xlsx-S11-Table_S11_The_results_of_the_MR_analysis_of_candidate_druggable_genes_and_cognitive_functions_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
4-aminobutyrate transaminase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.901
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
morphological abnormality of the gastrointestinal tract	GWASdb SNP-Phenotype Associations	1.0	0.142288
NCI-H2081	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE112761,GSE112767_2_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NL4W-0011-R8a-SM-2I3G4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871559
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.959722
BRD-K20951097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45438
cellular_component	GO Cellular Component Annotations 2015	1.0	null
ion binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-N7MS-0011-R6a-SM-2HMJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	2.29719
GTEX-WHSE-0011-R6A-SM-3P5ZP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5614
DMS454	CCLE Cell Line Gene CNV Profiles	-1.0	-2.37057
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.845257
GTEX-XMD1-0011-R6A-SM-4AT5K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77616
cisplatin_mus musculus_gpl339_gds3099	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-621	TargetScan Predicted Conserved microRNA Targets	1.0	0.404082
KELLY	CCLE Cell Line Gene Expression Profiles	1.0	2.65281
ID4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31805
CLPP_KO_GDS4791_108_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SPI1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.31465
NECAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00502
PMC9213552-41467_2022_30858_MOESM6_ESM.xlsx-Hu-FGF4_and_NANOG-List_of_the_genes_correlated_with_both_FGF4_and_NANOG_expression_in_ICMd_cells_NANOG	Rummagene Transcription Factor Associations 2026	1.0	null
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3236
spleen	GTEx Tissue Gene Expression Profiles	-1.0	-1.04469
disease	GWASdb SNP-Disease Associations	1.0	0.025129
PMC5840266-41598_2018_22384_MOESM13_ESM.xlsx-UBE3A_KD_significant-Unnamed_23_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K48764596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74681
gastrointestinal system disease	GWASdb SNP-Disease Associations	1.0	0.093689
17660535-TableS4b	GeneSigDB Published Gene Signatures	1.0	null
BRD-K63155804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08997
CRCGN010_HEPG2_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1823
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.85447
GTEX-WL46-0011-R7A-SM-3LK7X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33787
GSE113385_0_v_1_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	124.019
Peripheral nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.38
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042024
FD-59-TC81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.06859
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.67662
staurosporine-508	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CE-24-LQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.295503
GTEX-RNOR-0011-R4A-SM-3GAD3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9777
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN010_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36272
BICR18	CCLE Cell Line Gene CNV Profiles	-1.0	-1.89853
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.25983
GSE226316_6_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
769-P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32636
CRCGN015_HEPG2_48H:L24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22725
fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.0834
peritoneum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.142553
Keratocyst	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.025
intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.703536
cellular protein modification process	GO Biological Process Annotations 2015	1.0	null
Perturb_2153_KO_Ring1_SRP321271	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
FBLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10859
PMC13138062-mmc7.xlsx-DUGs_ESR1_targets-DUGs_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K73706189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03075
GTEX-N7MS-0011-R7a-SM-2HMKN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03664
BRD-K71493640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35738
Inherited metabolic disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.622
kidney cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062143
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Major depressive disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.539
icSARS-Cov_Day4_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.12357
GSE130081,GSE130082_5_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WVLH-3126-SM-3MJGA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827618
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.64439
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.21083
hsa-miR-4648	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AA-18-GQ83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.693463
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE136622_7_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.28876
SRA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18566
caudal division of IPC (area 39)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.34049
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0011-R6B-SM-4E3J6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87336
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5414054-ncomms15013-s11.xlsx-SupplementaryData10-Supplementary_Data_10_Genes_differentially_expressed_due_to_infection_in_IRF5-_-_compared_to_parent_KOLF2_cells_IRF5	Rummagene Transcription Factor Associations 2026	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2990-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202434,GSE202438_7_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.911588
GTEX-QDT8-0011-R7A-SM-32PKF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92471
MCM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3264
GSE202434,GSE202438_6_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
REC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.855654
hsa-miR-4290	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
VD-76-SO91_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.5172
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12823551-mmc2.xlsx-S1A-up_genes_Rbl2_KD_neuro-Unnamed_0_AR	Rummagene Transcription Factor Associations 2026	1.0	null
cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE115542_5_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE156454_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.0144
CTCFL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.6482
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.3189
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC5630028-supp_gr.220533.117_Supplemental_File_S9_TCGA_mutation_data.xlsx-SMGs_in_TP53_mutant_tumors-Unnamed_1_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
OCI-AML2	GDSC Cell Line Gene Expression Profiles	-1.0	-1.85814
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE219195_4_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
93T449	DepMap CRISPR Gene Dependency	1.0	2.18307
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE171177,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XLM4-0011-R4B-SM-4AT5C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09691
nrf1_22586274_liver_lof_mouse_gpl4134_gse35124	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.022378
parietal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
COLO829	CCLE Cell Line Gene CNV Profiles	1.0	1.33558
Neuron to neuron synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.425
trochlear nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.94349
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE248659_1_v_0_klf5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE230354_0_v_1_rheb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120612_6_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SK-N-DZ	GDSC Cell Line Gene Expression Profiles	1.0	1.65029
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.266042
SIMA	CCLE Cell Line Gene Expression Profiles	1.0	1.39633
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.893072
inner CP in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.946152
BRD-K30682979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09957
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.028275
clomifene-6648	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RV16_0Hour-B2B_None_GSE28904	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.66797
PMC9894241-pnas.2211429119.sd05.xlsx-G7_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
rh30	HPA Cell Line Gene Expression Profiles	-1.0	-0.969415
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
DAZAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0013
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K78847404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16656
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.219707
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_1day-MOI-10^4_None_GSE44441	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.80045
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05499
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
NIBAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06916
Uterine Carcinosarcoma_UCS_TCGA-ND-A4WA-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gastrointestinal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.535
BICR31	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41387
hsa-miR-4505	TargetScan Predicted Conserved microRNA Targets	1.0	0.065994
GTEX-RVPU-0011-R3A-SM-2XCAE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855097
MKN74	CCLE Cell Line Gene CNV Profiles	-1.0	-1.82104
HUP-T3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.929939
HDH_CAG knock-in_GDS3935_569_mouse_Striatum and cerebellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4763-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.219115
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.845041
CORL279	CCLE Cell Line Gene Expression Profiles	1.0	1.49741
AB-97-BI36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.424301
NCIH2073	CCLE Cell Line Gene Mutation Profiles	1.0	null
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15662
sknf1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.745
ventrolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.828637
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
CRCGN008_HEPG2_24H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3033
striatum_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.16391
BRD-K96491664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5721
Thalamus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.962202
inner portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14839
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K42968343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65536
GSE193258,GSE193259_5_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE174406_2_v_1_lin28b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DICER1_KO_GDS4504_583_mouse_bone marrow granulocyte-macrophage progenitors	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.53606
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Synaptic vesicle, resting pool	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.679
DCUN1D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32866
primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.8252
GTEX-S7SE-0011-R6A-SM-2XCD9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4915
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSK3B_knockdown_204_GDS4305	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.76713
BRD-K79020643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15531
internal male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055419
GSE95077_1_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K33865795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0435
GSE210885_2_v_4_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mononuclear cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.151568
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GA-94-MC54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293369
TRIM28	ChEA Transcription Factor Targets	1.0	null
GSE219195_0_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-upregulated_in_ATF4OE_txt-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GPX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06928
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LU-65	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.83853
GSE160293_3_v_1_celf6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K90977883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2325
CRCGN017_MCF10A.WT.HP_24H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76095
Perturb_10354_KD_MSI1_SRP288195	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.16132
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BC-3	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.07955
VI	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.863101
REST_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Protein kinase-like domain	InterPro Predicted Protein Domain Annotations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4707-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
jurkat e-6.1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.81379
POU5F1-18700969-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041069
Presynaptic actin cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.028
NCIN87	Achilles Cell Line Gene Essentiality Profiles	1.0	3.10449
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC70	Achilles Cell Line Gene Essentiality Profiles	1.0	1.92671
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3922-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.047969
HS 578T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.997109
GSE178714_6_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RBM17_02_138	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.64321
Neostriatum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.086
PMC7581777-41419_2020_3029_MOESM6_ESM.xlsx-MNX1_ChIP-Symbol_MNX1	Rummagene Transcription Factor Associations 2026	1.0	null
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.533204
MELJUSO	CCLE Cell Line Gene CNV Profiles	1.0	1.33789
brain_3b	HPA Tissue Sample Gene Expression Profiles	1.0	1.51393
GTEX-PVOW-0011-R3A-SM-32PKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30201
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN011_HEPG2_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62675
TestisGermCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.941981
PKBalpha_KO_GDS1784_194_mouse_Embryonic fibroblasts (MEFs) - 2h	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
HINFP	JASPAR Predicted Transcription Factor Targets	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A562-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AE-85-KE62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.34537
PMC6520398-41467_2019_10148_MOESM11_ESM.xls-FigS1a-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-378f	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GTEX-P44H-0011-R1A-SM-3NM8J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25568
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7841-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE224763_1_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
purine nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8703
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.936225
schizophrenia	GAD Gene-Disease Associations	1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
A-673	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3502
neuron part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044865
TMEM256	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03121
GSE203181_0_v_1_phosphoramidon_human	RummaGEO Drug Perturbation Signatures	1.0	null
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
KYSE220	DepMap CRISPR Gene Dependency	1.0	2.37606
Brain morphology (MOSTest)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.2699
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052298
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09574
PMC10055465-media-2.xlsx-ST18-Unnamed_16_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K65860773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16516
striatum_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.66094
BRD-K85972696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10586
colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.882701
Neurocirculatory asthenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.31
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	96.5965
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.659897
ht-1080 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.257907
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.25
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasmic vesicle part	GO Cellular Component Annotations 2015	1.0	null
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.872
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14073
Dendritic spine	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.559
GB1	CCLE Cell Line Gene CNV Profiles	1.0	1.35947
TGW	GDSC Cell Line Gene Expression Profiles	1.0	1.97588
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.1431
MAX	JASPAR Predicted Transcription Factor Targets	1.0	null
MAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4534
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE210101,GSE210114_4_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180641_0_v_1_zfp503_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_6501_KD_circSMO_SRP277579	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.1135
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.885559
POU5F1-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE146982_0_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
LNZTA3WT4	DepMap CRISPR Gene Dependency	1.0	6.65169
BRD-K02471501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.79682
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.39923
GSE234289_4_v_0_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XLM4-0011-R6A-SM-4AT4B	GTEx Tissue Sample Gene Expression Profiles	1.0	2.88997
GSE77108_4_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
III	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.900345
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.051359
PMC4825019__F5	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K70050144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08723
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
EZH2_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
semen	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.113544
BRD-K27719710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44999
NPIPB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08945
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051108
BRD-K31479652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29506
BRD-K55453160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23989
GSE210101,GSE210114_2_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.731442
germ layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057514
CRCGN014_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.6999
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K17209411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04725
Sarcoma_SARC_TCGA-MO-A47R-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
enlarged cecum	IMPC Knockout Mouse Phenotypes	1.0	null
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE210101,GSE210114_4_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KMT5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47888
CRCGN015_HEPG2_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.99856
CRCGN010_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.02494
BRD-K75807957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26766
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LY-294002-318	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K47984776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5454
GSE219195_1_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH2171	CCLE Cell Line Gene Expression Profiles	1.0	1.45795
GTEX-QDT8-0011-R4A-SM-32PKM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9778
PMC6365102-NIHMS1511350-supplement-2.xlsx-ST12-Unnamed_9_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
SNU1214	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41974
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.05698
GTEX-TSE9-0011-R5A-SM-3DB7J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.306
REST_Panc1_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-6778-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.17308
Prostate adenocarcinoma_PRAD_TCGA-EJ-8469-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WHSE-0011-R4A-SM-3P5ZN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9273
CRCGN017_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.69695
GSE102505_1_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19T-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCEA2	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN008_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.33345
Sarcoma_SARC_TCGA-QQ-A8VH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.60757
Neuron spine	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.558
blood vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060426
GTEX-QVJO-0011-R5A-SM-2S1QM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58371
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.72795
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH1651	CCLE Cell Line Gene Mutation Profiles	1.0	null
GSE158458_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Attention deficit hyperactivity disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.132
GTEX-OHPN-0011-R5A-SM-2I5FF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25598
EP300	ENCODE Transcription Factor Targets	1.0	null
cerebellum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16512
VA-48-RJ44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.320696
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.3703
mouth	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056199
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.844483
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.897267
GSE147662_3_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
VZ in subgenual cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06611
GSE175787_11_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.971515
C2CD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42816
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.909167
Hand1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.839
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223008_11_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K68618340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99384
RPRML	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21057
ZMAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22907
Calcium/calmodulin-dependent/calcium-dependent protein kinase	InterPro Predicted Protein Domain Annotations	1.0	null
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147662_0_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SK-MEL-28	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.92351
abducens nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.877575
GSE111660_1_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-N7MS-0011-R10A-SM-2HMJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16042
pempidine-6027	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17365_Mut|OE_Sik3E13_SRP334442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	11.0008
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
outer CP in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13757
CRCGN015_HEPG2_48H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.62744
PMC8755441-mmc3.xlsx-IRF3-Up-Symbol_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Appendix	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.885121
sulmazole-2153	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.84509
glia	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4b-REST_REST	Rummagene Transcription Factor Associations 2026	1.0	null
GlobusPallidus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.05281
MON	DepMap CRISPR Gene Dependency	1.0	2.50595
BF-49-KQ10_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216637
CRCGN017_MCF10A.WT.HP_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.5528
Carbohydrate metabolic disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.622
PMC9248879-supp_gr.275831.121_Supplemental_Table_S2.xlsx-TP53-dependent_proteins-GeneName_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27me3_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.5707
ribonucleoside binding	GO Molecular Function Annotations 2015	1.0	null
GSE102505_5_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RAF1_overexpression_220_GSE42964	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.57383
Perturb_16521_KD_ASXL3_SRP247927	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
CA1 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.970778
HMX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15752
GTEX-RU72-0011-R7A-SM-2TF5U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934547
GSE213410_2_v_3_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195568_2_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-0011-R5A-SM-4B657	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0323
BRD-K59772014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00227
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.25323
PMC12661646-dmm-18-052290-TableS7.xlsx-Table_S7_related_to_Fig5D-Fig_5D_-_overlap_between_genes_differentially_expressed_in_presence_absence_of_FOXP2_with_cerebellar_organoid_data_FOXP2	Rummagene Transcription Factor Associations 2026	1.0	null
Dendritic growth cone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.625
primary auditory cortex (core)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.14799
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7842-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.08822
crohn's disease	GWASdb SNP-Disease Associations	1.0	0.926808
SIN3A	ENCODE Transcription Factor Targets	1.0	null
lymphocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.103328
SUZ12	ENCODE Transcription Factor Targets	1.0	null
pyelitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.454847
GSE126127_5_v_3_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210682_0_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PARK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63571
Perturb_17594_KO_Pbrm1_SRP250724	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.12197
abnormal uterus morphology	MGI Mouse Phenotype Associations 2023	1.0	null
OCILY3	CCLE Cell Line Gene CNV Profiles	1.0	1.47998
GTEX-XOTO-0011-R1B-SM-4B65C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11834
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GTEX-WZTO-0011-R8A-SM-4E3II	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01046
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03419
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.575438
male reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055723
BC-54-ON71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.993166
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.932715
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
embryonic stem feeder layer	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.66333
GTEX-N7MS-0011-R2a-SM-2HML6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860226
SNPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36479
GTEX-T5JC-0011-R1A-SM-32PM6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30162
GSE169152_3_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC13138062-mmc7.xlsx-DUGs_E2F1_targets-DUGs_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K01077691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13029
VM-CUB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Morning person	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.75229
GSE113817_2_v_1_bach1_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.6202
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.72028
PMC5095001-oncotarget-07-36293-s002.xlsx-Table_S2-Table_S2_MYCN-correlated_genes_and_their_correlations_with_other_transcription_factors_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J8-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN008_HEPG2_24H:G24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.03495
CRCGN012_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92355
acronycine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08416
Sarcoma_SARC_TCGA-HS-A5N8-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE113817_0_v_1_bach1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44715
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL4W-0011-R10A-SM-2I3DY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944844
NuA4 histone acetyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.651
GSE217541,GSE217543_0_v_1_tet1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Superior frontal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.7
BRD-K67399222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37983
REST_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NMCG1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.59922
ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065884
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K71605668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47046
GTEX-TSE9-0011-R7A-SM-3DB7P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02951
KANSL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46733
GTEX-PVOW-2526-SM-2XCF7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3438
GTEX-T6MN-0011-R6A-SM-32QP8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80052
Perturb_17747_KO_Drd2_SRP238905	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.21307
GTEX-S7SE-0011-R10A-SM-2XCDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21684
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.95491
GSE113734_3_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WVLH-0011-R4A-SM-3MJFS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08633
HIF1A_01_224	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.333
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A6RX-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUN	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Nfatc2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.2603
ERG	ChEA Transcription Factor Targets	1.0	null
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17210682-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
posteroventral (inferior) parietal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.909658
SG in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.885126
GTEX-T5JC-0011-R8A-SM-32PLM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28537
GSE142210_4_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2756-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE120612_6_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HDAC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21212
H3K27me3_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PL4	DepMap CRISPR Gene Dependency	1.0	3.68364
BRD-K11672894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09423
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MZ7-mel	GDSC Cell Line Gene Expression Profiles	-1.0	-1.51008
gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142684_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Multiple synapse bouton	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.887
hsa-miR-424	TargetScan Predicted Conserved microRNA Targets	1.0	0.199275
BRD-K41853443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03562
GSE181513_2_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	1.0	null
deferoxamine-485	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TBCEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69098
hsa-miR-4468	TargetScan Predicted Conserved microRNA Targets	1.0	0.181316
NPW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18847
RPL32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29333
outer CP in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00119
Forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.086
GUCA1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08964
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE199255,GSE199356_3_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H4/H2A histone acetyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.649
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UTHO-0011-R3A-SM-3GIK8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962072
EGR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32153
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.66272
GTEX-R55E-2726-SM-48FCX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82596
Rectum adenocarcinoma_READ_TCGA-EI-6885-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10311050-mmc2.pdf-107-ENSG00000171223_JUNB	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47845
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.244232
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
testicular cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.39773
GSE129244_3_v_5_lmo2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5630028-supp_gr.220533.117_Supplemental_File_S9_TCGA_mutation_data.xlsx-SMGs_in_TP53_mutant_tumors-Unnamed_51_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.39188
GSE206729_4_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PRR15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24634
CRCGN015_HEPG2_48H:J17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.3338
Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.3917
parolfactory gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.34697
NCI-H810	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.70017
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.300197
specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.08439
ciclacillin-4358	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC5795782-supp_gad.302646.117_Supplemental_Table_S1.xlsx-Table_S1_2-Supplemental_Table_S1_2_Genes_significantly_upregulated_by_ARID5B_knockdown_ARID5B	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5989213-41467_2018_4462_MOESM8_ESM.xlsx-3-Supplementary_Data_3_List_of_2687_genes_differentially_expressed_between_SETBP1-G870S_and_Empty_293_FLP-In_lines_SETBP1	Rummagene Transcription Factor Associations 2026	1.0	null
lymphoid tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.85547
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052651
BRD-K94921631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0411
HINT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66745
YAPC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.852474
Female reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.291
NCIH508	CCLE Cell Line Gene Mutation Profiles	1.0	null
LN-229	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_17038_KD_Ikaros_SRP035941	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Perturb_7595_KD_NSUN2_SRP384110	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.78203
Prostate adenocarcinoma_PRAD_TCGA-CH-5750-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
D341MED	CCLE Cell Line Gene Expression Profiles	1.0	3.40799
CTV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052087
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8955
USF2	JASPAR Predicted Transcription Factor Targets	1.0	null
Perturb_462_KO_RUVBL1_SRP241670	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.96952
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210398
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149870_0_v_1_pfn1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.84566
PMC6930440-jcav11p0520s3.xlsx-MI_vs_FG-Unnamed_0_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
TE15	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.32837
BE-68-PM13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.330821
male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
orbital frontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.43644
protein phosphorylation	GO Biological Process Annotations 2015	1.0	null
HCC4006	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04422
GSE129241_3_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
NR1I3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0351
MPHOSPH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80801
GTEX-X4XX-3026-SM-3NMB2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42757
Retinoblastoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K48755012	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5015
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.943015
benzydamine-3169	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE60837_0_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LB1047RCC	DepMap CRISPR Gene Dependency	1.0	2.15313
CRCGN015_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58152
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mesoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06412
calcium- and calmodulin-dependent protein kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.294
BRD-K44722328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20011
Male reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
General cognitive ability	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.909691
CRCGN009_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.70131
PMC6766969-PATH-249-90-s005.xlsx-S1_b-Supplementary_Table_S1_b_Top_100_upregulated_and_downregulated_genes_in_TAF15-NR4A3_vs_EWSR1-NR4A3_EMC_NR4A3	Rummagene Transcription Factor Associations 2026	1.0	null
cytoplasm	LOCATE Curated Protein Localization Annotations	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65606
cerebellar cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06825
NCI-H1993	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE213153_1_v_0_ulixertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K57575504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49446
DE-28-XP50_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.275762
GTEX-TSE9-0011-R6A-SM-3DB7L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71797
BRD-K64698045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23045
CD-13-QZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.460967
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.344337
BRD-K12801140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55105
hmc1	HPA Cell Line Gene Expression Profiles	-1.0	-0.969415
BRD-K68890376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.30715
GSE142210_2_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26261
monocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.185366
mono-mac-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.11509
GTEX-WHSE-0011-R7A-SM-3P5YZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45468
oxybutynin-3168	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QDT8-0011-R6A-SM-32PKI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979081
BRD-K07129792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09358
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5779
GTEX-RVPU-0011-R5A-SM-2XCAD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25092
PF-00539758-00-6416	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_HEPG2_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.6276
BRD-K51175229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47811
GSE164874_5_v_10_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-N7MT-0011-R10A-SM-2I3E1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05939
PMC13082837-NIHMS2159075-supplement-3.xlsx-DataTable5_Methylation_LMS-UCSC_RefGene_Name_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
Mitochondrial fatty acid beta-oxidation multienzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.933
NHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	97.2028
CRCGN016_MCF10A.TP53.M_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3268
GTEX-T6MN-2626-SM-32PMQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42322
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K28952606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6464
BRD-K45874102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38101
BRD-K81801123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95887
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
lower (caudal) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17861
Brain Lower Grade Glioma_LGG_TCGA-HW-7489-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
QA-07-KC40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262539
gastrointestinal inflammation	GWASdb SNP-Phenotype Associations	1.0	0.3201
BRD-K25305749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48804
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.78872
BRD-K71298594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50575
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE199255,GSE199356_6_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142684_0_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
sirolimus_homo sapiens_gpl2895_gse16944	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
SKNO1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.39172
DMS53	CCLE Cell Line Gene CNV Profiles	-1.0	-2.0109
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09689
hsa-miR-92a-3p	MiRTarBase microRNA Targets	1.0	null
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051919
GSE138001_2_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Huntington's disease-like 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051587
GSE211262,GSE211263_3_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ABT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13404
Rubrospinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.525
KLF10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	125.595
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COV362	Achilles Cell Line Gene Essentiality Profiles	1.0	1.48482
SKNAS	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32701
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE208171_0_v_1_zc4h2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
inner CP in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.875106
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN010_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46785
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-3925-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
adenoid	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.454126
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ATXN7L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13765
Mesothelioma_MESO_TCGA-TS-A7P8-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.53004
PSN1	CCLE Cell Line Gene CNV Profiles	1.0	1.76579
ampyrone-1402	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
t-lymphocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.01681
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K51167279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50459
GSE169356_0_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917207
Acute Myeloid Leukemia_LAML_TCGA-AB-2866-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVJO-0011-R10A-SM-2S1QJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24314
GTEX-NPJ7-0011-R10A-SM-2I3E5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19719
BRD-K17895004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00044
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	237.545
hsa-miR-3918	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
Intelligence (MTAG)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.12218
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0011-R4A-SM-32PLT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.989758
Disease of metabolism	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.622
P4E6	DepMap CRISPR Gene Dependency	1.0	2.31806
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE151782_3_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.6414
bloom syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.736243
etiocholanolone-4298	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE206729_4_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PWO3-0011-R5A-SM-2I5EZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902939
alprenolol-3188	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
premotor cortex (area 6)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.947955
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-378e	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
BRD-K53992608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49631
CRCGN015_HEPG2_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.56279
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-QVJO-0011-R1A-SM-2S1QI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03839
GSE60837_0_v_3_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1187	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.899043
telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.1828
hsa-miR-4252	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GTEX-NL4W-0011-R6a-SM-2I3GA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66043
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A8P0-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040692
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.05052
adrenal gland	HPA Tissue Gene Expression Profiles	1.0	1.22197
SNUC2A	CCLE Cell Line Gene Mutation Profiles	1.0	null
PMC7069022-Table_1.xlsx-MYCN_Cor_Microarray_Analysis-GENE_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K75990394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0637
MEK_OE_GDS1925_165_human_Estrogen receptor (ER) alpha positive MCF-7 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
KNS60	Achilles Cell Line Gene Essentiality Profiles	1.0	1.01131
PMC3435504-msb201237-s2.xls-Supp_Table_4a-REST_REST	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.955407
posteroventral (inferior) parietal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.919559
MHHES1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57601
GTEX-XOTO-0011-R7B-SM-4B64R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23919
GSE115542_5_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TK10	BioGPS Cell Line Gene Expression Profiles	1.0	1.271
TC71	Achilles Cell Line Gene Essentiality Profiles	1.0	1.14501
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.703945
HT115	CCLE Cell Line Gene CNV Profiles	1.0	1.83416
REST_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37399041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07597
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.67533
ZNF708	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7786
ZNF263	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.8949
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BF-49-QA17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.356926
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
REST_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
H4K20me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OHPN-0011-R7A-SM-2I5FI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09254
PMC6928094-395_2019_765_MOESM6_ESM.xlsx-DEGs_AR11_vs_AR1-List_of_differentially_expressed_genes_in_AR11_vs_AR1_Negative_value_means_down-regulation_in_AR11_TCF20	Rummagene Transcription Factor Associations 2026	1.0	null
fendiline-3190	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K72386335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69499
NUGC4	CCLE Cell Line Gene CNV Profiles	-1.0	-2.25091
5666823-609	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K36197756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01614
RFX5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLPP_KO_GSE40207_381_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CRCGN014_HEPG2_3H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.83925
sclc21h	HPA Cell Line Gene Expression Profiles	1.0	1.41346
BRD-K03662481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94849
GSE143662_0_v_1_dcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
M14	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K67319345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12962
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A5W7-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE238005_0_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12661646-dmm-18-052290-TableS9.xlsx-Table_S7_related_to_Fig5D-Fig_5D_-_overlap_between_genes_differentially_expressed_in_presence_absence_of_FOXP2_with_cerebellar_organoid_data_FOXP2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.38866
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36054
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
vascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058646
SK-N-AS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.897
Postsynaptic specialization	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.432
BRD-K64266251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33426
dopamine-491	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE133516_0_v_6_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
host cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.139487
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.35248
PMC5630028-supp_gr.220533.117_Supplemental_File_S9_TCGA_mutation_data.xlsx-SMGs_in_TP53_mutant_tumors-Unnamed_6_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GATA2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE205976,GSE205978_1_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
Embryo Loss	CTD Gene-Disease Associations	1.0	1.18685
Perturb_6516_KD_PDXP_SRP106855	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.7469
SLC7A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03712
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.92914
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.3561
RBBP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08229
GTEX-QVUS-0011-R4A-SM-3GAE7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.940393
GSE169356_2_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
TMEM120B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06894
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.373
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.75087
CRCGN015_HEPG2_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.72062
MXI1	ENCODE Transcription Factor Targets	1.0	null
Protein kinase domain	InterPro Predicted Protein Domain Annotations	1.0	null
FAM83E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27296
lidocaine-4596	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	161.838
ZXDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34383
Liver Diseases	CTD Gene-Disease Associations	1.0	1.01739
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WVLH-0011-R5A-SM-3MJFW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42683
SNU475	CCLE Cell Line Gene Expression Profiles	-1.0	-2.07628
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATAD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34769
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.65072
autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.047936
BRD-K76492619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29693
hsa-miR-4659a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
organic cyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8107-01A-13R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_16480_KO_Ring1a/Ring1b_SRP136563	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	18.4815
GSE174418,GSE174421_0_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IV, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09
BRD-K90736603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17099
BRD-K66189308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92429
BRD-K64509231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11183
CRCGN013_HEPG2_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39521
NFATC3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3453
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-Row_names_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-2909	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
Whole Blood	GTEx Tissue Gene Expression Profiles 2023	1.0	4.90243
hsa-miR-1286	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GTEX-TSE9-3026-SM-3DB76	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25225
PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_downregulated-Ensembl_ID_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K52148119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21482
GTEX-TSE9-0011-R1A-SM-3DB7E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.977903
hsa-miR-4419a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
ZNF148	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	130.233
SP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.876256
BRD-K70127757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37591
Perturb_9238_KD_ENL_SRP074134	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.34838
H3K27ac_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.770575
PTEN_DELETION_GDS2446_59_human_HCT116 colon cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.43615
hsa-miR-1296	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
Major depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
CRCGN017_MCF10A.WT.HP_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3564
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.848439
CLPP_KO_GSE40207_397_mouse_Brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SKRC20	Achilles Cell Line Gene Essentiality Profiles	1.0	1.04092
chlorzoxazone-1416	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K39649774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05055
TEAD1	JASPAR Predicted Transcription Factor Targets	1.0	null
KNS81	Achilles Cell Line Gene Essentiality Profiles	1.0	1.42264
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31307
PTEN_DELETION_GDS2446_710_human_HCT116 colon cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.63421
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.7422
GTEX-S7PM-0011-R6A-SM-3NM8F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831399
Small Intestine - Terminal Ileum	GTEx Tissue Gene Expression Profiles 2023	1.0	1.74457
GSE151612_4_v_11_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.808
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08901
BRD-K14813155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05234
PMC10025425-mmc3.xlsx-ADNP_WH-gene_ADNP	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SNUC5	DepMap CRISPR Gene Dependency	1.0	2.12355
REST_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.896928
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A197-06A-32R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KMS-11	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.74746
KARPAS-620	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.00682
GSE120413,GSE120447_3_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.68802
JA-79-II25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.533433
hexestrol-6077	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.54404
GTEX-S7SE-0011-R5A-SM-2XCDA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45555
Inflammation	CTD Gene-Disease Associations	1.0	1.03641
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB7C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.8929
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DMS273	CCLE Cell Line Gene Expression Profiles	1.0	1.91337
Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0EZ-01A-21R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH82	CCLE Cell Line Gene Expression Profiles	1.0	2.06948
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.8646
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-50	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.86047
HTK	CCLE Cell Line Gene Expression Profiles	-1.0	-2.22428
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01511
PMC5303304-13073_2017_407_MOESM5_ESM.xlsx-mycn-sy5y-se_single_24DMSO_vs_4-Table_S4_Genes_differentially_expressed_by_48h_Dox_MYCN_overexpression_treatment_DE_comparison_with_SY5Y-MYCN_control_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
SIN3A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.086
PMC10645393-jci-133-169200-s102.xlsx-Table_S14_AR-V_DNA-PK_DEGs-Supplementary_Table_14_Overlapping_DEG_list_from_CWR22Rv1-AR-EK_cells_depleted_of_AR-V7_and_treated_with_DNA-PK_inhibitor_NU5455_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K44759088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09317
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3211
GSE247084,GSE247087_0_v_1_cdyl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31712
BRD-K78315404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.49308
GTEX-RNOR-2326-SM-2TF4I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4714
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAL1	ENCODE Transcription Factor Targets	1.0	null
JHOM1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.8519
CALM1	Hub Proteins Protein-Protein Interactions	1.0	null
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-4457	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.94001
NCI-SNU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
REST_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.39876
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K29028138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14641
inner CP in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.937624
CLOCK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9156
FE-06-GR60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210922
CRCGN015_MCF10A_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.1734
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-KDM5B-Members_of_the_KDM5B_regulon_as_identified_by_SCENIC_KDM5B	Rummagene Transcription Factor Associations 2026	1.0	null
RFX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-6917-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K93590856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29647
GSE152432_5_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE188884,GSE189078_2_v_3_ebf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
protozoan form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.075952
LUC7L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46133
posteroventral (inferior) parietal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.20256
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09574
H3K4me3_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
COLO849	CCLE Cell Line Gene CNV Profiles	1.0	2.19846
cimetidine-1884	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-1202	TargetScan Predicted Conserved microRNA Targets	1.0	0.348832
ABCA1_OE_GDS2303_189_mouse_LDL receptor-deficient livers	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12198403-41398_2025_3437_MOESM1_ESM.xlsx-S9-Table_S9_The_results_of_the_MR_analysis_of_significant_druggable_genes_and_cognitive_performance_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
peripheral blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.285316
BRD-K51270604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4183
REST_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE86507,GSE86509_3_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126127_0_v_1_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146982_4_v_2_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RUNX1_KO_GDS1511_251_mouse_Embryos at E12	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SNU520	CCLE Cell Line Gene Mutation Profiles	1.0	null
Organism form	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.172
GTEX-PVOW-0011-R1A-SM-32PL6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19075
GSE162590_1_v_0_gsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
embryoday6.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.05253
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4843-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EE-03-SG02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.339887
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.35318
BICR18	CCLE Cell Line Gene Mutation Profiles	1.0	null
SOHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3442
ribavirin-3142	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.64591
18223198-TableS3	GeneSigDB Published Gene Signatures	1.0	null
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47369
CRCGN017_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.29545
Overexertion_Leukocyte_GSE3606	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.32005
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4468	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
AP1M1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11433
CAPAN1	CCLE Cell Line Gene CNV Profiles	1.0	2.54256
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3610249-1471-2164-14-184-S4.xls-miR-331-3p_targets-NR2E3_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K48035513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53813
CD-20-MH57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207217
CRCGN015_HEPG2_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.5801
BRD-K38975326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84233
hippocampus	HPA Tissue Protein Expression Profiles	1.0	1.47108
nucleoside phosphate binding	GO Molecular Function Annotations 2015	1.0	null
MCF12A	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.19561
PLEKHG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09704
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
GTEX-QVUS-0011-R1A-SM-3GAD2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825227
NCI-H2795	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3502
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.42857
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.69663
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Spleen	GTEx Tissue Gene Expression Profiles 2023	1.0	1.10561
Perturb_2055_KD_NR2F2_ERP124128	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-NPJ8-0011-R10A-SM-2YUMO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22983
COLO 205	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.893072
hsa-miR-760	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.078404
acute lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.136183
KDM5A	ENCODE Transcription Factor Targets	1.0	null
H3K27me3_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68836091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.00272
dipyridamole-5617	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4480	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXO1_KD_GDS2720_478_mouse_LSK	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
HT55	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K33603918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10751
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-EVX1_EVX1	Rummagene Transcription Factor Associations 2026	1.0	null
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.10168
Parahippocampal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.966
PMC5105166-ncomms13331-s5.xlsx-Sheet1-Supplementary_Data_4_Gene_expression_signature_of_MEF2D-rearranged_cases_stranded_data_only_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
ZBTB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.8051
PDSS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29292
hsa-miR-4659b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.172
KXD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21243
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07295
CDAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39501
GSE97352_1_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
outer portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.967106
striatum_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.890232
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17508
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RT112	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39955
CRCGN013_HEPG2_24H:J20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11353
hydrometra	MGI Mouse Phenotype Associations 2023	1.0	null
SP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	120.361
CPCN	CCLE Cell Line Gene Expression Profiles	1.0	1.39139
Acute Myeloid Leukemia_LAML_TCGA-AB-2903-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K02929561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59232
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Primary hematopoietic stem cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.32471
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5561-01A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.866936
RAJI	CCLE Cell Line Gene Mutation Profiles	1.0	null
BL-41	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	167.769
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.75087
vinpocetine-3174	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K68980973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57611
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.263
GSE128333_3_v_5_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Sarcoma_SARC_TCGA-MJ-A850-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K72675584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21626
BRD-K30812092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41283
LEMD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03711
H4K20me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K59683187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05401
U251	GDSC Cell Line Gene Expression Profiles	-1.0	-1.54318
Bipolar disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.263
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.962661
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.906001
GTEX-RNOR-0011-R7A-SM-2TF4V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5093
hsa-miR-4755-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.336728
GTEX-Q2AG-2926-SM-2HMJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34142
OCUM1	DepMap CRISPR Gene Dependency	1.0	3.48506
GTEX-OHPN-0011-R1A-SM-2I5GB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900104
GSE123861_1_v_0_sin3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K66311249	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71171
lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.126346
promazine-6028	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27me3_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
heterocyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
CRCGN017_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.05037
GSE201657_0_v_1_ash2l_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE115542_2_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.01865
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
cinnarizine-3175	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.576939
PK-59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.929939
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.2386
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.9415
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE109530,GSE109531_1_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	117.738
gilles de la tourette syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.714408
HL60	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.03722
PMC11330984-41467_2024_51229_MOESM6_ESM.xlsx-MYC_UP-ID_SYMBOL_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K81956993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13164
BRD-K90103010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10356
Gastrointestinal tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.31
H3K27me3_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8425-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
oocyte	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.06259
Fallopian Tube	GTEx Tissue Gene Expression Profiles 2023	1.0	2.40495
molindone-4199	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF484	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01797
GSE84148,GSE96938_0_v_2_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223008_9_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7610-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.836877
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.8626
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.962661
BRD-K67278762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26861
SSH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31017
membrane	GO Cellular Component Annotations 2015	1.0	null
bj	HPA Cell Line Gene Expression Profiles	-1.0	-0.969415
blast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061071
C-33-A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
solanine-2808	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QMR6-0011-R10A-SM-32PKO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15957
ZNF787	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49478
monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046769
NCIH1341	CCLE Cell Line Gene Expression Profiles	1.0	1.51347
inner CP in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.911798
cerebellar cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.984658
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
19808870-ST1	GeneSigDB Published Gene Signatures	1.0	null
PFKL_OE_GDS1980_203_mouse_dermal fibroblasts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_24H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0944
CTCF_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Unnamed_12_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K20068050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05868
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.932704
GTEX-X4XX-0011-R1B-SM-3P622	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935954
regulation of modification of postsynaptic structure	SynGO Synaptic Gene Annotations	1.0	null
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3304
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K28448768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36094
CHP126	CCLE Cell Line Gene Expression Profiles	1.0	1.51588
monastrol-668	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
nucleus accumbens, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.2472
EBF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.3329
GTEX-N7MT-0011-R6a-SM-2I3G3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8746
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.79508
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.296
NCIH460	DepMap CRISPR Gene Dependency	1.0	2.39909
GSE214931_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_8_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0998
GSE120612_7_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K68008192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32199
CRCGN015_MCF10A_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.48509
CRCGN015_HEPG2_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.09746
GSE210870_0_v_1_snai1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OXRN-0011-R5A-SM-2I5EF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02841
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.35364
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.816607
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1092	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K70183558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41317
Perturb_730_KD_ELAVL1_SRP293637	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.78908
GSE184133,GSE184137_1_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPMI-7951	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34073
GTEX-UTHO-0011-R4A-SM-3GIJP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930206
GSE198165,GSE198166_6_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-4.02871
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.028953
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.262
GTEX-WHSE-0011-R5A-SM-3P5ZO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64183
CAL33	CCLE Cell Line Gene CNV Profiles	-1.0	-1.62248
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE180185_4_v_10_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
retinoblastoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
REST_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09621
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCIH2066	CCLE Cell Line Gene CNV Profiles	-1.0	-1.52339
GTEX-PWO3-0011-R3A-SM-2I5EX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873292
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217102
Lung adenocarcinoma_LUAD_TCGA-91-8499-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_16731_KO_Myc/Pin1_SRP069191	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.30257
GSE160817_4_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.10455
atp binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-NL4W-0011-R4a-SM-2I5GZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921736
GTEX-Q2AG-0011-R6A-SM-2HML7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.784
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.6818
CRCGN009_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16625
TSPAN14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34548
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.909658
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.51408
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-15a	TargetScan Predicted Conserved microRNA Targets	1.0	0.226173
BRD-K47999752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65808
posteroventral (inferior) parietal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02515
PMC11682006-13105_2024_1045_MOESM1_ESM.pdf-99-TFAP2E_TFAP2E	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146982_0_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RCOR1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
dengue hemorrhagic fever	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.559062
Lateral ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.31
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1497
GTEX-NPJ7-0011-R6a-SM-2I3G7	GTEx Tissue Sample Gene Expression Profiles	1.0	2.15042
NLRP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96467
labetalol-3167	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
fluoxetine_mus musculus_gds2803	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Primary hematopoietic stem cells G-CSF-mobilized Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.5155
CRCGN010_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35614
SP in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.865274
GSE210101,GSE210114_6_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WHSE-0011-R1A-SM-3P5ZK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49813
CRCGN014_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0089
BRD-K65831955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29974
caudal (posterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05181
CRCGN016_MCF10A.TP53.M_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.88565
NCIH1694	CCLE Cell Line Gene CNV Profiles	-1.0	-1.71084
MDAMB134VI	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3413
ETV2::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1853
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_10_v_6_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-Q2AG-0011-R5A-SM-2HMJH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7921
CCRF-CEM	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SH-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPI1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE169152_5_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K75853175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54161
Kidney	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.01423
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	211.781
vero cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.285671
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-2861	TargetScan Predicted Conserved microRNA Targets	1.0	0.154935
lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.756191
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053159
igg immunoglobulin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.182122
skeletal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064136
calmodulin-dependent protein kinase activity	GO Molecular Function Annotations 2023	1.0	null
FXR	MotifMap Predicted Transcription Factor Targets	1.0	null
SMAD2/3-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GATA3	ENCODE Transcription Factor Targets	1.0	null
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
clozapine-416	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K18686200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18167
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16512
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.907596
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HEC1B	CCLE Cell Line Gene Mutation Profiles	1.0	null
F36P	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.06181
GSE173911,GSE173917_0_v_1_morc3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LN229	CCLE Cell Line Gene Mutation Profiles	1.0	null
gut epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.446807
GSE126345_7_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T6MN-0011-R1A-SM-32QOY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10615
MYC_KD_GSE22139_685_human_medulloblastoma	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE120413,GSE120447_4_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.76536
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.83798
MOLT4	BioGPS Cell Line Gene Expression Profiles	1.0	0.982204
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KLF4-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
YJEFN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83007
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	159.61
KDM5B	ENCODE Transcription Factor Targets	1.0	null
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29135
Lung squamous cell carcinoma_LUSC_TCGA-85-7696-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYH14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02164
tanespimycin-381	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN011_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.26985
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7289-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8558-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RINL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68409
OB-65-AI50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.581638
CRCGN014_HEPG2_3H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1322
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.83865
CRCGN014_HEPG2_24H:J15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.12665
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_y_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
TCF12	ENCODE Transcription Factor Targets	1.0	null
trunk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052694
GSE140937,GSE140938_0_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XMD1-0011-R8A-SM-4AT48	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85325
Schizophrenia	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K75551005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85239
BRD-K55522699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1452
GSE139348,GSE139349_1_v_0_dicer1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S7SE-0011-R8A-SM-2XCDG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.992204
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.317562
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.8538
hippocampus (hippocampal formation)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.986614
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
VZ in rostral cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12152
large intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.258917
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.97247
PMC12198403-41398_2025_3437_MOESM1_ESM.xlsx-S13-Table_S13_MR_results_of_candidate_druggable_genes_and_white_matter_structure_in_IVW_or_Wald_ratio_methods_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16495
BRD-K43326597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07228
NCIH2126	CCLE Cell Line Gene Mutation Profiles	1.0	null
GTEX-OXRN-2426-SM-2I5EQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11331
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
E2A	MotifMap Predicted Transcription Factor Targets	1.0	null
JUN_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cetirizine-2468	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.36057
BRD-K51398207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2645
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18801
E2F6	ENCODE Transcription Factor Targets	1.0	null
BRD-K41355409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.94469
AML193	CCLE Cell Line Gene CNV Profiles	1.0	1.56598
19658189-TableS4	GeneSigDB Published Gene Signatures	1.0	null
H3K27me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.270068
GSE158834_2_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
functional abnormality of the gastrointestinal tract	GWASdb SNP-Phenotype Associations	1.0	0.236656
GTEX-X261-0011-R6B-SM-4E3J8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853692
natamycin-6126	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.536957
raloxifene-388	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.21932
USF1	JASPAR Predicted Transcription Factor Targets	1.0	null
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46056
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.976798
MYOD1_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216273,GSE216292_14_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NB-69 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.818
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE139975_3_v_0_rnf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12659123-12864_2025_12285_MOESM12_ESM.xlsx-Table_S12-Table_S12_Differentially_expressed_genes_after_SPI1_knockdown_SPI1	Rummagene Transcription Factor Associations 2026	1.0	null
rofecoxib-205	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
purine ribonucleoside binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-QDT8-0011-R10A-SM-32PKG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09377
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23259
SNU840	Achilles Cell Line Gene Essentiality Profiles	1.0	1.68548
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0265
ZNF816	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.9031
GTEX-XOTO-0011-R6B-SM-4B65X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16095
Reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
Prostate	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.01879
G140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15539
u26684	HPA Cell Line Gene Expression Profiles	-1.0	-0.969415
GTEX-WL46-0011-R1A-SM-3LK6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18816
cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K90918886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31644
BORA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34023
BRD-K65410345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29893
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M9-01A-23R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-422a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
ZNF101	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35113
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.12637
phosphorus metabolic process	GO Biological Process Annotations 2015	1.0	null
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.06455
mRNA_MYC_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
POU5F1-18347094-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-497	TargetScan Predicted Conserved microRNA Targets	1.0	0.226173
BRD-K95768123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05975
HELA	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.08881
GSE224969,GSE224971_0_v_7_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169152_5_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Rectum adenocarcinoma_READ_TCGA-CI-6619-01B-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.05035
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10993
GSE126345_9_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03634
BRD-K07770425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.42032
PMC13137955-ijbsv22p4243s2.xlsx-Sheet1-hTFtarget_E2F3_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE153443_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
REST_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0011-R4A-SM-2XCDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07708
IGR-37	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.85696
NF-21-HQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.09682
CRCGN012_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.07367
BRD-K77733130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0141
Brain Lower Grade Glioma_LGG_TCGA-WY-A859-01A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K76426411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21437
Subcortical volume (min-P)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.35229
GSE158632_2_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.257005
AC-43-ZC52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.428402
REST_PFSK-1_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.28802
GSE160817_2_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CDH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53441
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-548p	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112761,GSE112767_4_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QMR6-0011-R7A-SM-32PKL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933056
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.93395
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TG-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147662_3_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Epiblast cell_Embryo_Human	CellMarker Gene-Cell Type Associations	1.0	null
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
cytoplasmic vesicle membrane	GO Cellular Component Annotations 2015	1.0	null
Choroid plexus epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.784
BRD-K93223696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71437
PMC5630028-supp_gr.220533.117_Supplemental_File_S9_TCGA_mutation_data.xlsx-SMGs_in_TP53_mutant_tumors-Unnamed_21_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
Attention deficit hyperactivity disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.89
SLC46A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58248
GSE127790_9_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.71378
BRD-K97410356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03853
BRD-K41970046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22929
GSE152441,GSE152442_6_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178113,GSE178116_0_v_1_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062404
cerebellar cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.92182
macromolecule modification	GO Biological Process Annotations 2015	1.0	null
NCI-H2126	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00864
PMC12670081-mct-24-0704_supplementary_table_s10_suppst10.xlsx-Supplementary_Table_S10-Supplementary_Table_S10_Differential_expression_of_TFCP2-rearranged_RMS_Vs_Other_RMS_FC_3_padj_0_01_TFCP2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE224969,GSE224971_0_v_5_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K91648652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11442
GTEX-X4XX-0011-R5A-SM-46MWN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874941
FXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68721
ZBTB7A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE205163,GSE205164_9_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.538461
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-N7MS-0011-R3a-SM-33HC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2211
BRD-K86453556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60479
GSE210101,GSE210114_5_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormality of the gastrointestinal tract	GWASdb SNP-Phenotype Associations	1.0	0.103958
GSE199255,GSE199356_4_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
postsynapse	SynGO Synaptic Gene Annotations	1.0	null
GSE158632_3_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7856-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K68594161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32672
cerebellar cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.31005
BRD-K70254692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.46614
cell part	GO Cellular Component Annotations 2015	1.0	null
Perturb_5260_KD_Ubn2_SRP323703	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-15.6457
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.806439
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1314
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
QA-58-CX23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.408632
COPS5	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4749-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
ACVR2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04883
Lung adenocarcinoma_LUAD_TCGA-NJ-A55R-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01872
Perturb_8576_OE_Xbp1_SRP288940	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.48317
BRD-K63212062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91901
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.40816
MLH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0803
CA1 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.36818
CRCGN012_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3386
GSE233647_4_v_5_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WVLH-0011-R6A-SM-3MJFZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34357
PMC5630028-supp_gr.220533.117_Supplemental_File_S9_TCGA_mutation_data.xlsx-SMGs_in_TP53_mutant_tumors-Unnamed_46_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.72248
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.24689
internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-QVJO-0011-R9A-SM-2S1QH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05459
pimozide-3178	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
viral envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.179459
hsa-miR-4498	TargetScan Predicted Conserved microRNA Targets	1.0	0.115091
PMC5630028-supp_gr.220533.117_Supplemental_File_S9_TCGA_mutation_data.xlsx-SMGs_in_TP53_mutant_tumors-Unnamed_56_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
PTPRZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11606
PMC11461876-42003_2024_6975_MOESM3_ESM.xlsx-Supplementary_Data_1-Supplementary_Data_1_Differentially_Expressed_Genes_HSE_THP1_Vs_THP1_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE223008_0_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-1913	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.66397
other source	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073705
purine nucleoside binding	GO Molecular Function Annotations 2015	1.0	null
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K56ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE126345_0_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Acute stress disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.038
GSE137914_0_v_1_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4825019__F5	PFOCR Pathway Figure Associations 2023	1.0	null
GSE56235_1_v_0_prdm11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_4151_KO_Csmd3_SRP343147	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.61662
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.825421
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.932088
primary somatosensory cortex (area S1, areas 3,1,2)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.4727
Perturb_13976_KO_H3f3a/H3f3b_ERP109384	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.30118
GSE217363_0_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13647
NCI-H2347	COSMIC Cell Line Gene Mutation Profiles	1.0	null
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-RU72-0011-R5A-SM-2TF6U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51245
GTEX-QVJO-0011-R2A-SM-2S1QK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09898
Postsynaptic density	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.442
BRD-K26647686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02733
CRCGN015_HEPG2_48H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.38521
CRCGN016_MCF10A.TP53.M_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21053
hsa-miR-3150a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040825
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.96
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_821_OE_Rspo1_SRP325709	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.302168
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K26976202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46642
SN12C	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-NPJ7-0011-R4a-SM-2I3GJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930396
GTEX-WL46-0011-R5A-SM-3LK6V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36295
GSE112860_9_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
posteroventral (inferior) parietal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.53606
Ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.086
CRCGN015_HEPG2_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.93627
clindamycin-1373	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.9
b-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.093187
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0011-R4a-SM-2HMKW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871344
hsa-miR-4731-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.082179
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3843
CRCGN016_MCF10A.TP53.M_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.8056
BxPC-3	GDSC Cell Line Gene Expression Profiles	-1.0	-1.51886
GTEX-TSE9-0011-R4A-SM-3DB7H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06116
BRD-K68383485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12931
GTEX-QMR6-0011-R5A-SM-32PKT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983245
protein serine/threonine kinase activity	GO Molecular Function Annotations 2023	1.0	null
CHAGOK1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50171
GSE129244_3_v_1_lmo2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195568_3_v_4_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
sarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.086453
BRD-K98749544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74239
UO31	CCLE Cell Line Gene CNV Profiles	1.0	1.55291
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.285
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	1.0	1.67882
inflammation of the large intestine	GWASdb SNP-Phenotype Associations	1.0	0.399119
ZFP281-18757296-E14-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE185519_4_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE130437_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-NL3H-0011-R3a-SM-2I3GL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03965
LC-12-VN85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.903172
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3599
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
fibrosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.23604
AB-12-IS33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.858926
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TTC21B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03651
GSE199255,GSE199356_6_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.111
GSE210101,GSE210114_2_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158632_3_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	1.14404
RINT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33834
BDCA4+_DentriticCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.82758
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.21328
female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
hsa-miR-532-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
DBTRG05MG	DepMap CRISPR Gene Dependency	1.0	3.18523
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K49132774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10487
PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_downregulated-Gene_name_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.78732
FOXP1_01_209	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60524
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.97979
Melancholic depression	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.539
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07985
hsa-miR-4322	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.98154
hsa-miR-1182	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18801
hsa-miR-30d-3p	MiRTarBase microRNA Targets	1.0	null
kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.064526
Endometriosis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.291
CRCGN014_HEPG2_3H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.03245
BRD-K94145457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05996
BRD-K63209730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13758
gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.385936
mainolfactoryepithelium.MOE.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.866828
chr3_49902070_C_T_b38	GTEx eQTL 2025	1.0	1.46975
TAF1	ENCODE Transcription Factor Targets	1.0	null
hybridoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.724041
CLPP_KO_GDS4791_377_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
transferase activity, transferring phosphorus-containing groups	GO Molecular Function Annotations 2015	1.0	null
BRD-K64553072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94078
Endosomal scaffold complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.238
RI1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54902
PMC10528072-NIHMS1928302-supplement-5.xlsx-NEUROD1-target_genes-AANAT_NEUROD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K47170544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48243
GSE158834_7_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.14964
hsa-miR-195	TargetScan Predicted Conserved microRNA Targets	1.0	0.226173
PMC7608835-aba3058_Table_S5.xlsx-RING1B_EWS-FLI1_ACTIVATED-RING1B_EWSR1-FLI1_activated_genes_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE110248_1_v_6_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL3H-0011-R6a-SM-2I3G8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04214
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32177
PMC5630028-supp_gr.220533.117_Supplemental_File_S9_TCGA_mutation_data.xlsx-SMGs_in_TP53_mutant_tumors-Unnamed_41_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
isradipine-3129	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-UTHO-0011-R6A-SM-3GIJW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60808
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSS	CCLE Cell Line Gene CNV Profiles	-1.0	-2.44229
BRD-K56024445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36699
small molecule binding	GO Molecular Function Annotations 2015	1.0	null
leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.091652
PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1c-List_of_1682_genes_differentially_regulated_by_GLI1_FDR_0_1_GLI1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
APP	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A772-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Genetic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.622
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.529
KLF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.09
XRCC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05208
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.5862
PMC6026875-MOL2-12-1104-s002.xlsx-List_of_Cancer_Associated_Molec-Tet-MIST1_Cancer_Molecules_BHLHA15	Rummagene Transcription Factor Associations 2026	1.0	null
pravastatin-lactone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71071
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Male reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039739
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAZ_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K34910830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20302
GSE150072,GSE169209_6_v_11_qser1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Stat5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.4426
CRCGN014_HEPG2_3H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7253
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO-679	GDSC Cell Line Gene Expression Profiles	-1.0	-1.50674
GTEX-QDT8-2926-SM-32PKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22173
REST_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE84462,GSE84762_0_v_1_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WHSE-0011-R3A-SM-3P5ZM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12529
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32454
GSE174498,GSE174500_2_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
Teratocarcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040977
Diabetes mellitus	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.622
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4768-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.404082
CMLT1	CCLE Cell Line Gene Mutation Profiles	1.0	null
PRIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66628
BACH1	ENCODE Transcription Factor Targets	1.0	null
CRCGN012_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.61516
protein phosphorylation	GO Biological Process Annotations 2023	1.0	null
GSE195568_3_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.176485
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.87663
FUS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45704
EZH2_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
host intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.242076
GTEX-WWYW-3126-SM-3NB39	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3682
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146982_4_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K63853589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55125
BRD-K25761766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11241
NCI-H82	GDSC Cell Line Gene Expression Profiles	1.0	1.47382
SARS-BatSRBD_Day4_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.75682
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PC3	CCLE Cell Line Gene CNV Profiles	1.0	1.5349
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.6024
CRCGN017_MCF10A.WT.HP_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2256
copper sulfate-459	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.05128
AMPA glutamate receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.166
primary somatosensory cortex (area S1, areas 3,1,2)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.28229
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
REST_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.717
lymph node	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.284962
Uterine Carcinosarcoma_UCS_TCGA-N6-A4VD-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.63147
H3K27me3_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.028927
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050994
BRD-K58863944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07655
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Ikzf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	49.9628
BRD-K02747732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47125
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.62308
CRCGN014_HEPG2_3H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.36319
GSE216043_11_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5630028-supp_gr.220533.117_Supplemental_File_S9_TCGA_mutation_data.xlsx-SMGs_in_TP53_mutant_tumors-Unnamed_16_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-26a-5p	MiRTarBase microRNA Targets	1.0	null
ZC3H8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02349
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HRT18	CCLE Cell Line Gene Mutation Profiles	1.0	null
GTEX-WL46-0011-R10A-SM-3MJFQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29194
JJN3	DepMap CRISPR Gene Dependency	1.0	2.50014
Perturb_3486_KO_Mettl3_SRP273291	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-14.6325
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.946192
A2780	GDSC Cell Line Gene Expression Profiles	-1.0	-1.6655
Intelligence	DisGeNET Gene-Phenotype Associations	1.0	null
primary motor-sensory cortex (samples)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.25037
OMC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
primary motor-sensory cortex (samples)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12251
VZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19948
CRCGN015_HEPG2_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.73087
GSE216273,GSE216292_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-PWO3-0926-SM-2I5EY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863452
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20428
primary motor-sensory cortex (samples)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08419
OSC20	DepMap CRISPR Gene Dependency	1.0	2.8203
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	145.789
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.32135
H3K4me2_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
skeletal muscle cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.084425
TEAD4	ENCODE Transcription Factor Targets	1.0	null
Cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.086
CRCGN014_HEPG2_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.21815
GSE92434_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AGO1_02_162	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61411
GSE189356_5_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.97962
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-378c	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Perturb_4793_KD_Tex10_SRP056038	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
ACTB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09944
SNB19	CCLE Cell Line Gene CNV Profiles	1.0	1.64112
BRD-K47197953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16458
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cortical surface area (MOSTest)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.6
RFX5	ENCODE Transcription Factor Targets	1.0	null
GSE157036,GSE166411_3_v_1_halofuginone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE162892_3_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216043_10_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
liothyronine-4947	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
20860821-TableS5	GeneSigDB Published Gene Signatures	1.0	null
Fatty acid beta-oxidation multienzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.93
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.503932
GSE120413,GSE120447_4_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary auditory cortex (core)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.8998
Depressive disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.539
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.39147
Perturb_3487_KO_Kctd13_ERP112326	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.61708
ZMYND11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15302
neuron projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.062401
SKMM2	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.47619
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.297465
Perturb_13188_KO_Rbfox2_SRP216887	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.01784
MDAMB415	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pons	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.31354
DB-73-BC12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.346893
VZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05491
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.4386
GTEX-QVUS-0011-R3A-SM-3GAFD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12787
BRD-K91998226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74743
GTEX-UTHO-0011-R5A-SM-3GIJD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72125
cerebellum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.883881
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.873016
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.244
K562	BioGPS Cell Line Gene Expression Profiles	1.0	0.84281
loracarbef-5073	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ICC10	DepMap CRISPR Gene Dependency	1.0	3.81547
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19052
upper limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07335
glioma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CALU-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.826754
HNF4	MotifMap Predicted Transcription Factor Targets	1.0	null
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.991219
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain	HPA Tissue Gene Expression Profiles	1.0	2.24804
CRCGN012_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4574
daudi	HPA Cell Line Gene Expression Profiles	-1.0	-0.969415
Perturb_18511_KD_UHRF1_SRP217518	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
CRCGN014_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.2066
E2F6_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE97352_3_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
embryonic stem no feeder	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.868108
GTEX-X4XX-0011-R4B-SM-46MWL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937755
NCI H23	BioGPS Cell Line Gene Expression Profiles	1.0	1.10409
BRD-K57687960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04154
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.270068
MAX	ENCODE Transcription Factor Targets	1.0	null
SH3BGRL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52884
hsa-miR-3972	TargetScan Predicted Conserved microRNA Targets	1.0	0.32519
Nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.172
HCC1937	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_820_OE_Rspo1_SRP325709	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GTEX-P44H-0011-R10A-SM-2XCEK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03066
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IQ-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2171	GDSC Cell Line Gene Expression Profiles	1.0	1.47441
JD-62-HR05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.454031
Yy1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.2985
hsa-miR-4296	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE140651,GSE140653_2_v_0_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
mRNA_SETDB1_19884255	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
sin3a_22783022_mcf7_lof_human_gpl570_gds4388	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.103346
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QC-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lymphoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.101404
tioguanine-642	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ParietalLobe	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.879965
GSE151612_0_v_11_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mood disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.539
TUNAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28662
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09574
testis_7d	HPA Tissue Sample Gene Expression Profiles	1.0	0.839281
BRD-K49635910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07594
GTEX-XLM4-0011-R10A-SM-4AT5P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2
BRD-K57489406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66233
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MW-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1793	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09706
hsa-miR-4492	TargetScan Predicted Conserved microRNA Targets	1.0	0.140752
LC-12-VN85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.256023
GTEX-PWO3-0011-R8A-SM-2I5GD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927273
H413	DepMap CRISPR Gene Dependency	1.0	2.14071
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.13455
CRCGN014_HEPG2_24H:G24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14596
GATA1-19941827-MEL86-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BD-48-ZT65_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.385875
medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.31151
BRD-K17412949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24098
ZNF354C	JASPAR Predicted Transcription Factor Targets	1.0	null
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.40074
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
geldanamycin-611	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RVPU-0011-R10A-SM-2XCAH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01205
BRD-K81082552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20251
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.39
Inferior frontal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.881
L-type voltage-gated calcium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.506
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE65617_2_v_3_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8419-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL3H-0011-R5a-SM-2I3GB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.908089
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H446	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.851808
CRCGN011_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3097
CRCGN015_HEPG2_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.78854
gut	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.090235
CRCGN015_MCF10A_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.1404
SK-N-AS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38975
fibrosarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.220152
GSE231799_3_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HS822T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.68735
Perturb_7260_KD_EP300_SRP193326	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K34907403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62555
monocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.072309
fertilizedegg	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.479
TRIM28-19339689-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K80622681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75629
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K56107062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15446
Head	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.172
BRD-K11399565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77878
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.854114
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4813-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4761-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.111118
BRD-K61441533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93918
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.2033
LNZ308	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.48305
SYK_KD_GDS3609_440_human_MCF10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_-2-1280_genes_are_more_than_four-fold_downregulated_in_PRDM8-_-_compared_to_control_PRDM8	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4113-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.930143
EZH2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48121
BRD-K07152092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84546
dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.160254
Age at first birth	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.4301
MHH-NB-11	GDSC Cell Line Gene Expression Profiles	1.0	1.47829
anion binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-T5JC-2426-SM-3NMDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57553
BRD-K44787496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19172
GSE248858_4_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
spleen	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.311145
Lung squamous cell carcinoma_LUSC_TCGA-66-2754-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHMP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10194
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00154
KDM4A	ENCODE Transcription Factor Targets	1.0	null
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-fromNode_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K51228600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03559
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.920789
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4162954-12864_2014_6430_MOESM3_ESM.xlsx-2102Ep-Genes_deregulated_in_2102Ep_cells_after_SOX2_knock-down_FDR-corrected_P-value_0_05_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
BRD-K65663356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56022
hippocampus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.23083
enlarged cecum	MGI Mouse Phenotype Associations 2023	1.0	null
Neuropil	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.151
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-3.35518
CRCGN015_HEPG2_48H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76055
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K25056189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.36135
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.47853
BRD-K73177528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15112
SPI1	ChEA Transcription Factor Targets	1.0	null
H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-378h	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE210101,GSE210114_8_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T6MN-0011-R5A-SM-32QPD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8973
PLB985	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.61864
GTEX-QMR6-0011-R6A-SM-32PKP	GTEx Tissue Sample Gene Expression Profiles	1.0	2.03597
GTEX-WWYW-0011-R5A-SM-3NB3E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27024
CRCGN015_HEPG2_48H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2183
Perturb_1311_KO_Cntnap4_SRP386887	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.64538
GTEX-R55E-0011-R5A-SM-2TC5N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25017
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCT15	CCLE Cell Line Gene Mutation Profiles	1.0	null
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.31867
REST_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12661646-dmm-18-052290-TableS5.xlsx-Table_S7_related_to_Fig5D-Fig_5D_-_overlap_between_genes_differentially_expressed_in_presence_absence_of_FOXP2_with_cerebellar_organoid_data_FOXP2	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q1-06A-21R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
crohn's disease	GWASdb SNP-Phenotype Associations	1.0	0.81601
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18684
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42689
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_19_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53274037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59794
GSE84462,GSE84762_0_v_7_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
outer CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.916
NCIH661	CCLE Cell Line Gene Mutation Profiles	1.0	null
DETROIT562	DepMap CRISPR Gene Dependency	1.0	11.6621
BRD-K96243955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20072
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.6197
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.850993
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.963198
NCI-H446	GDSC Cell Line Gene Expression Profiles	1.0	1.42009
culture fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.476589
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	174.75
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SUM185PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.753236
Lung	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.26445
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.28949
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.00083
E2F6_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.827753
Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K29253960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23201
BRD-K78262424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52398
hsa-miR-15b	TargetScan Predicted Conserved microRNA Targets	1.0	0.219115
Brain Lower Grade Glioma_LGG_TCGA-HT-7688-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.45171
ZNF281	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	144.839
GTEX-R55F-0011-R8A-SM-2TF4F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.913644
Postsynaptic actin cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.971
CRCGN017_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.3091
NTRK2_drugactivation_66_GSE20358	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-0.901161
GSE169356_0_v_5_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
888	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.88703
H3K27me3_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.693876
Prostate adenocarcinoma_PRAD_TCGA-CH-5788-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.812
PSN1	CCLE Cell Line Gene Expression Profiles	1.0	1.44532
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
virion	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.501476
GTEX-WZTO-0011-R5B-SM-3NMC5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31907
Microcystic adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.512
VZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.8524
EGR1	ENCODE Transcription Factor Targets	1.0	null
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.85379
GSE205163,GSE205164_1_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043665
rt4	HPA Cell Line Gene Expression Profiles	-1.0	-0.969415
MOLT-13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.318
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.57255
HCN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23877
NCI-H2461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.840223
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4595011-pgen.1005555.s001.xlsx-BPTF_UP-regulated-Ensembl_gene_id_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K74568352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32777
Prostate cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
Neuroblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.406
hsa-miR-378d	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE189683_1_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
purine ribonucleoside triphosphate binding	GO Molecular Function Annotations 2015	1.0	null
REST_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.46525
KIJK	CCLE Cell Line Gene Mutation Profiles	1.0	null
LIVF001-029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38332
BRD-K78432272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10183
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.21597
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.165
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NPJ8-0011-R3a-SM-2HMIW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847068
BRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34875
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K12741517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0403
Periglomerular cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.933
GSE258991_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K65257143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37856
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.872017
BRD-K81779733	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33085
protein serine/threonine kinase activity	GO Molecular Function Annotations 2025	1.0	null
posteroventral (inferior) parietal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.852529
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.73493
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.50611
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE109530,GSE109531_2_v_3_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_12021_KO_Nsmce2_SRP102277	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.3062
BRD-K72687327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08274
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-CA-ID_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE172458_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5173-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4375
GSE137702_2_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE124932_2_v_1_sarm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETV4_ETV4	Rummagene Transcription Factor Associations 2026	1.0	null
fluphenazine-3194	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.99493
JA-79-II25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.454015
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4735-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEP57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37875
cytoplasmic vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
BRD-K49094605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.121
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.117
JIMT-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.911588
SF-67-CJ22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302655
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lateral ventricle	HPA Tissue Protein Expression Profiles	1.0	1.47108
vesicle membrane	GO Cellular Component Annotations 2015	1.0	null
BRD-K93986444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05523
BRD-K52630978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13988
GSE210101,GSE210114_6_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GSE223008_7_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR1F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21868
GSE149096_4_v_3_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K54934070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53898
GSE126402_1_v_3_tal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPL23A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64294
CTCF_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K69879051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33278
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
FF-86-NH56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.06871
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.664299
BC-14-CG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218133
HEC1B	CCLE Cell Line Gene CNV Profiles	1.0	2.3085
hsa-miR-329	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
DHCR24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16826
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7952
SCLC21H	CCLE Cell Line Gene Mutation Profiles	1.0	null
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9439
valproic acid-410	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
acute lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.128183
GTEX-X585-0011-R3B-SM-46MVG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20016
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A7WH-01A-22R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K65836113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18855
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST	ENCODE Transcription Factor Targets	1.0	null
DLX5_Deficiency_GDS4443_355_mouse_E10 embryos	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
VZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.69847
GSE185519_3_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WBP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36262
HT144	DepMap CRISPR Gene Dependency	1.0	3.90109
ChIP_TCF3_18347094	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
EGR1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.12476
SP1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ENGASE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19691
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE262134_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K75807882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37405
GSE142684_3_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
membrane	LOCATE Curated Protein Localization Annotations	1.0	null
NCIH28	CCLE Cell Line Gene CNV Profiles	1.0	2.04471
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09574
BRD-K35441510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32013
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.25017
Alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.31
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.1921
H3K4me1_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7881-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H4K91ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.72028
GSE132948,GSE132949_4_v_5_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174498,GSE174500_5_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.555
PMC9882185-media-4.xlsx-Neuron_KD-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Mesothelioma_MESO_TCGA-TS-A7P0-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JURKAT, CLONE E6-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
JiyoyeP-2003	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.76653
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.851808
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMARCD1-25818293-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K94062017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11941
ANO8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25604
MHHNB11	CCLE Cell Line Gene Expression Profiles	1.0	2.25477
GSE199255,GSE199356_4_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-762	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
clofilium tosylate-3187	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
QF-71-QI30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.776877
BRD-K76748254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06573
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K50129495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20342
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.0852
MXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5868
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.35411
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF454	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	148.859
GSE211983_0_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.78649
Perturb_14976_OE_Zfp189_SRP156780	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.29922
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE136622_0_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RNF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02769
testis	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.52402
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K10911459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40435
carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.163111
GTEX-X4XX-0011-R10B-SM-46MWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35034
BC-00-YH62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266068
GSE110268_1_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
frontal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
ulcerative colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.882701
SNU1105	CCLE Cell Line Gene Mutation Profiles	1.0	null
Perturb_1072_KO_Fermt2_SRP342700	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.0228
BRD-K89174739	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06035
GSE130690,GSE130692_1_v_0_sirt6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE240896,GSE240899_2_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K91467861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34566
ntera2	HPA Cell Line Gene Expression Profiles	1.0	1.45466
Carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
GTEX-N7MT-0011-R4a-SM-2I3G9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.882914
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	104.35
GTEX-T2IS-3126-SM-32QPK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838559
GSE233647_2_v_3_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-30c-5p	MiRTarBase microRNA Targets	1.0	null
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.905997
LM-1685-612	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE112860_5_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
REST_01_211	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.29463
ZNF320	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	220.534
CRCGN009_HEPG2_24H:N19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2569
PHB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44215
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.28058
disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.558285
BRD-K61796560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87469
MAX_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04367
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.729797
BRD-K22093396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47623
Corpus striatum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.086
TEX41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30479
BRD-K50443235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41518
PMC12198403-41398_2025_3437_MOESM1_ESM.xlsx-S14-Table_S14_MR_results_of_candidate_druggable_genes_and_cortical_and_subcortical_structure_in_IVW_or_Wald_ratio_methods_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K23342427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07609
CRCGN015_MCF10A_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.1997
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K07697589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12972
BRD-K58248556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21046
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.32221
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
praziquantel-3189	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K75842461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46488
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.48896
H3K27me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7153
PRMT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40747
THAP1	ENCODE Transcription Factor Targets	1.0	null
496100496_FWM_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.07347
INMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16118
hsa-miR-1266	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
imatinib-366	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9575
TBP	ENCODE Transcription Factor Targets	1.0	null
CRCGN017_MCF10A.TP53.M_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.2462
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.745864
Dendritic filopodium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.668
KPNYN	CCLE Cell Line Gene Expression Profiles	1.0	1.84032
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.16391
GSE138818_1_v_0_nanog_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.223662
BRD-K68635551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2747
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-4.71268
GSE131673_0_v_1_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K20203275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31501
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XLM4-3026-SM-4AT6L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33484
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-2690-01A-02R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Glucose metabolism disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.622
BRD-K81952048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36665
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EPAS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2719
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.885619
peripheral blood mononuclear cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.195347
Perturb_6578_KO_Zeb2_SRP066910	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE175787_13_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GABP	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE198165,GSE198166_5_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164874_5_v_11_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K66416915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0883
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.31
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.1467
GTEX-R55F-0011-R6A-SM-2TF4L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53437
GSE142684_4_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.68054
GTEX-X585-0011-R6A-SM-46MVJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93494
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_TRIM28_19339689	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
trigeminal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.33413
KP363T	DepMap CRISPR Gene Dependency	1.0	3.03162
GSE217541,GSE217543_3_v_1_tet1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4c-REST_REST	Rummagene Transcription Factor Associations 2026	1.0	null
MTOR_UP.N4.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.126346
Crus II, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.65206
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
ATXN1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05432
posteroventral (inferior) parietal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.29892
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K60437668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14368
BRD-K91282650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06616
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:L09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9019
GTEX-X4XX-0011-R3B-SM-46MWK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21963
cerebellar cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.939274
VPS37D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19015
BRD-K61278167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39459
BRD-K78439758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93166
BRD-K66013406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00862
BRD-K67725403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68411
NFIC	ENCODE Transcription Factor Targets	1.0	null
GTEX-R55E-0011-R1A-SM-2TC6N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13492
H3K27me3_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04835
upper (rostral) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.893023
NCIH524	CCLE Cell Line Gene Expression Profiles	1.0	2.38593
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-d-Classification_of_camel_SON_basal_genes_-_enzymes_SON	Rummagene Transcription Factor Associations 2026	1.0	null
TBX2-33478486-IMR90-HUMAN-LUNG	ChEA Transcription Factor Targets 2022	1.0	null
Pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.117
GSE248858_4_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K48880196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30204
8505C	CCLE Cell Line Gene CNV Profiles	1.0	1.33098
post-traumatic stress disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.497
ST6GAL1_Deficiency_GDS3151_608_mouse_Mammary tumors	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HEC108	CCLE Cell Line Gene Mutation Profiles	1.0	null
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.75621
GTEX-WHSE-0011-R8A-SM-3P5Z1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865793
hsa-miR-4751	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GSE142210_4_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.49367
ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
Postsynaptic cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.698
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.991069
NCI-H2731	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.78784
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.274
HS229T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48636
NCIH2081	CCLE Cell Line Gene Mutation Profiles	1.0	null
cardiovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05737
NCI-H1793	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7292-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZIC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.4034
valproic acid-409	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0457
EXOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1483
GSE205687_1_v_0_mta1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K72894736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31309
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.10127
hsa-miR-127-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.226173
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.257
POU5F1	ChEA Transcription Factor Targets	1.0	null
BTRC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00652
dorsal thalamus_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.894411
Basal telencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.565
GSE210580_4_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
pituitary	GTEx Tissue Gene Expression Profiles	1.0	1.20413
GTEX-QDT8-0011-R1A-SM-32PKS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07081
PMC10140619-mmc5.xlsx-Rank_Beta1-Beta3-Gene_BHLHE22	Rummagene Transcription Factor Associations 2026	1.0	null
Cloneh	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.807
GSE216043_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
calmodulin binding	GO Molecular Function Annotations 2015	1.0	null
GSE136622_6_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.27352
16293578-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
trophozoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.239913
GSE143782_3_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_642_KD_FASTKD1_SRP299834	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.99271
jurkat cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.266413
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
CRCGN017_MCF10A.TP53.M_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01946
BRD-K06956443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53076
Perturb_7583_KO_MBD6_SRP360138	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.8377
hsa-miR-4510	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Skin Cutaneous Melanoma_SKCM_TCGA-W3-A825-06A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10140619-mmc5.xlsx-Beta3_ConVsBSL-Gene_BHLHE22	Rummagene Transcription Factor Associations 2026	1.0	null
tuberculosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.33944
AR_01_192	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.81335
HCC1806	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.40033
NB12	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.17907
BRD-K66619295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11501
GSE94849_6_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
SOHLH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04996
NCI-H508	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Sarcoma_SARC_TCGA-FX-A8OO-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T6MN-0011-R7A-SM-32QP5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9002
BRD-K73582217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.00592
cerebellar cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1814
GTEX-T5JC-0011-R5A-SM-32PLK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52945
increased freezing behavior	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-K52310606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07128
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
16353136-Table3	GeneSigDB Published Gene Signatures	1.0	null
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.936271
A-498	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.932088
Tet21N cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.849
TRIM28_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.06578
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Cell type cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
GTEX-P44H-0011-R8A-SM-2XCEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08047
abducens nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.3689
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15775_OE_Nmnat1_SRP360949	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.92164
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain morphology (min-P)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.739794
GSE210101,GSE210114_5_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NL3H-0011-R4a-SM-2I3GK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938662
BRD-K58220038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21392
GTEX-OXRO-0011-R10A-SM-2I5EH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.889207
GSE147662_2_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
caco2	HPA Cell Line Gene Expression Profiles	1.0	0.924243
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSP90AA1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-16	TargetScan Predicted Conserved microRNA Targets	1.0	0.226173
BRD-K09271653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60997
gonad	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Glioma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE174751_0_v_1_postn_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-4656	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
BRD-K86925685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1112
GSE158975_0_v_1_spp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-654-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GSE158632_2_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.486
Perturb_7501_KD_EP300/YAP1_SRP193326	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.08857
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	118.404
Uterine Carcinosarcoma_UCS_TCGA-N8-A4PM-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-EV-5903-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
eucatropine-3759	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abdomen	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070929
MYOD1	ENCODE Transcription Factor Targets	1.0	null
striatum_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15423
CRCGN015_HEPG2_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.58555
SNU668	DepMap CRISPR Gene Dependency	1.0	3.6514
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE152441,GSE152442_1_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K89532826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63196
CRCGN012_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43904
NTRK3_drugactivation_67_GSE20358	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-0.901161
inner CP in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.934071
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42555
CRCGN009_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06322
CHD7	ENCODE Transcription Factor Targets	1.0	null
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.0912
Educational attainment	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.33979
prostate gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060348
primary motor cortex (area M1, area 4)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.950519
DB-73-BC12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.323453
biperiden-5644	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K21384875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00351
BRD-K56131419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41171
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
CRCGN015_MCF10A_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.19952
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IMR-32 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.883
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
umbilical vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.214017
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POU5F1-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE173810_0_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.233
GTEX-T6MN-0011-R8A-SM-32QP3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870064
KRAS.DF.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
pharynx	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.079397
head of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.905924
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041607
sporozoan form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.116731
fetus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057191
CRCGN017_MCF10A.WT.HP_24H:E04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.33917
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mRNA_NIPBL_20720539	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K82791632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03157
GSE216043_11_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.05542
GSE219195_1_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
H2BK12ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Anxiety disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.38
SIRT3_KO_GDS4817_416_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
intestinal disease	GWASdb SNP-Disease Associations	1.0	0.315834
CRCGN017_MCF10A.TP53.M_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16664
ELF1	ENCODE Transcription Factor Targets	1.0	null
GSE164505,GSE164506_3_v_2_indisulam_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_11_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04421
TT	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.82197
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.07222
GEO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-4518	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
Brain Lower Grade Glioma_LGG_TCGA-DU-A7T6-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PLAG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	110.056
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7II-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-1280	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11714
Perturb_4365_KO_UTX/JMJD3_SRP158713	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
biological_process	GO Biological Process Annotations 2015	1.0	null
BHT101	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47647
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POU5F1-18700969-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC12041165-401_2025_2886_MOESM1_ESM.xlsx-Meta_CAA_vs_AD-Genes_TSHZ1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.99849
HL60	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.13896
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QVUS-2826-SM-3GADB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06332
Lung adenocarcinoma_LUAD_TCGA-55-8620-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PWO3-0011-R1A-SM-2I5EW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83038
flufenamic acid-1420	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K67491390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48326
Anorexia nervosa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.011
ZNF740	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	189.547
viral membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.166167
GSE176008_7_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A634-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NALM-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34992
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE109140_2_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.3468
Perturb_5230_KO_Kmt5b/Kmt5c_SRP194976	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
BRD-K60306319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1609
hsa-miR-4417	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE202434,GSE202438_13_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KP3	DepMap CRISPR Gene Dependency	1.0	2.7884
monocytic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.188483
GSE111660_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF569	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98033
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12661646-dmm-18-052290-TableS6.xlsx-Table_S7_related_to_Fig5D-Fig_5D_-_overlap_between_genes_differentially_expressed_in_presence_absence_of_FOXP2_with_cerebellar_organoid_data_FOXP2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K68949590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.69774
hsa-miR-30a-5p	MiRTarBase microRNA Targets	1.0	null
RFX5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
NCI-H661	COSMIC Cell Line Gene Mutation Profiles	1.0	null
phagocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066223
Perturb_8660_KO_TP53_SRP251281	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.91016
GSE253943_1_v_2_bhlhe40_human	RummaGEO Gene Perturbation Signatures	1.0	null
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.176
REST_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-DY-A1DD-01A-21R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCC13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN009_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.40165
JHH2	CCLE Cell Line Gene Mutation Profiles	1.0	null
HEC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.854262
GSE111247_11_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QMR6-0011-R4A-SM-32PKU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839176
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ANKLE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35262
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-8_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27669
A172	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.28008
GSE169571_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE198165,GSE198166_6_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:C02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0754
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.40472
PMC10978835-41698_2024_566_MOESM1_ESM.pdf-19-CUX2_CUX2	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.95937
Brain Lower Grade Glioma_LGG_TCGA-FG-7643-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AA-99-HO76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.719885
Perturb_12629_KD_CYGB_SRP388176	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.33049
GTEX-XOTO-0011-R3A-SM-4B64W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15593
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.0476
PMC11342283-mmc4.xlsx-LPS_vs_ATP_LPS-UCSC_RefGene_Name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12499388-ADVS-12-e01774-s002.xlsx-Table_S1-Table_S1_Differentially_Expressed_Genes_between_wild-type_and_TET3-knockout_PANC-1_cells_TET3	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08302
GSE198165,GSE198166_5_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4723-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
CRCGN014_HEPG2_24H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.3322
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09419
BRD-K87853964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32254
OSR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6603
Acute Myeloid Leukemia_LAML_TCGA-AB-2832-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.4138
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.909658
sarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.089893
posteroventral (inferior) parietal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.991644
GSE231799_3_v_5_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WZTO-0011-R10B-SM-4E3KB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34642
lymphoblastoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.106463
MAFG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15395
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.893072
BRD-K46428124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11135
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PCI-15A	COSMIC Cell Line Gene CNV Profiles	-1.0	-5.12655
BRD-K58757743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39772
BRD-K82409466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22872
FC-20-EQ58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.0404
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K81439435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15873
BD-18-MM33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.88849
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZC-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78N-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE122067_2_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
pseudopodium	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.284401
VZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08219
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
brain	GTEx Tissue Gene Expression Profiles	1.0	2.18034
TC-67-HF87_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.351466
BRD-K90127324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90127
Periventricular nucleus of hypothalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.621
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.13684
PMC4609150-13073_2015_228_MOESM2_ESM.xlsx-TP53-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K22443456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00715
cofilin-actin rod	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.542
hsa-miR-4476	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.829306
rectal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.725311
CRCGN012_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.29949
Subcortical volume (MOSTest)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.0
vertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058886
GSE152432_3_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.963483
PMC9630632-Table1.XLSX-diff_exp_genes-Group_1_vs_2_AND_Group_2_vs_3_NOT_Group_1_vs_3_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2879-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_4872_KO_EZH1/EZH2_SRP095403	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.979061
BRD-K41700289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55364
CAL120	CCLE Cell Line Gene CNV Profiles	1.0	1.49728
isocarboxazid-3684	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A6S6-01A-21R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4472	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
BRD-K22390389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46815
GSE210101,GSE210114_6_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
phosphotransferase activity, alcohol group as acceptor	GO Molecular Function Annotations 2015	1.0	null
GSE143662_3_v_1_dcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.23144
Developmental disorder of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.89
cerebellar cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.36077
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03597
nucleus accumbens, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.5693
GSE86507,GSE86509_7_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5630028-supp_gr.220533.117_Supplemental_File_S9_TCGA_mutation_data.xlsx-SMGs_in_TP53_mutant_tumors-Unnamed_11_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K29802952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22981
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.6503
PMC5830929-supp_gad.301887.117_Supplemental_Table_S3.xlsx-Sheet1-Downregulated_genes_in_CHD7-KD_and_CHARGE_NE_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K64763803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29736
BRD-K45984211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56363
GSE101336_1_v_3_decitabine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70G-01B-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE165579_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF816	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00668
GTEX-NPJ8-0011-R4a-SM-2HML3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82691
BRD-K89992188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35086
VF-12-MF80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236044
BRD-K73048554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09158
Perturb_4211_KO_Fmr1_SRP354984	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.30628
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.2506
GSE164757,GSE164759_1_v_0_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-18-MM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.23449
chromosomal part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.048216
BRD-K44480322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17488
SPI1	ENCODE Transcription Factor Targets	1.0	null
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HD-29-LW24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.673588
ERG-21242973-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XLM4-0011-R7A-SM-4AT5L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94047
PMC6420765-12864_2019_5550_MOESM5_ESM.xlsx-D4_vs_D9-Unnamed_4_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE138938_1_v_2_foxp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9882185-media-4.xlsx-Neuron_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
LOXIMVI	GDSC Cell Line Gene Expression Profiles	-1.0	-1.49838
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.0905
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.03491
hsa-miR-544b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GTEX-T5JC-0011-R7A-SM-32PME	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39917
TE9	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.31046
BRD-K07420629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3573
PMC8755441-mmc3.xlsx-IRF3-Up-Symbol_1_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
AP-4	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K27me3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193351_1_v_2_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_38_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
SCLC21H	CCLE Cell Line Gene Expression Profiles	1.0	1.5994
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.180367
ChIP_K27me3_17603471_mouseMEF	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PA-TU-8902	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.962661
Rectum adenocarcinoma_READ_TCGA-DC-6157-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-XQ-A8TA-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WL46-0011-R6A-SM-3LK6X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26302
CRCGN013_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.721
GTEX-T2IS-3026-SM-32QPM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38005
BRD-K71496240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89778
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
solasodine-6025	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-X585-3026-SM-46MWF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42704
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZU-06A-12R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054594
GSE175787_8_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LY-294002-461	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SPI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE173873_1_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH1755	DepMap CRISPR Gene Dependency	1.0	2.09371
CRCGN012_HEPG2_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.80023
H3K9ac_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
colitis	GWASdb SNP-Phenotype Associations	1.0	0.399119
GSE133516_5_v_2_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
bcl11b_18199763_brain_lof_mouse_gpl1261_gds3178	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.969599
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.824748
Isocitrate dehydrogenase complex (NAD+)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.754
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	90.3553
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00729
Embryonic brain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.172
posteroventral (inferior) parietal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.825389
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.172
HS683	DepMap CRISPR Gene Dependency	1.0	2.22617
pirinixic acid-368	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.69458
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052355
GSE226770_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CAMA1	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.4863
HEYA8	DepMap CRISPR Gene Dependency	1.0	3.23518
697	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.43744
BRD-K75186244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57378
chronic colitis	GWASdb SNP-Phenotype Associations	1.0	0.399119
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
VA-48-RJ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.324628
cerebellar cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.77544
GSE151612_4_v_10_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
rofecoxib-371	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K86961579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0031
PANX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00922
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.18456
USF2	ENCODE Transcription Factor Targets	1.0	null
Presynaptic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.14
BRD-K61599229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05818
KPNRTBM1	CCLE Cell Line Gene Expression Profiles	1.0	1.5979
GTEX-QMR6-1426-SM-32PLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27358
BRD-K54549319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73131
GSE205976,GSE205978_3_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AE-39-DG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.13594
BRD-K45609222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56949
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-WL-A834-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-DX-A7ER-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TK10	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.07415
P63-20808887-KERATINOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-XOTO-0011-R8A-SM-4B65J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87703
Contractile ring	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.532
CRCGN015_HEPG2_48H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.8795
WDR91	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10088
hydrometra	IMPC Knockout Mouse Phenotypes	1.0	null
GSE210101,GSE210114_1_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HMGB1P1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35394
BRD-K43192836	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03954
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.970373
GTEX-RU72-0011-R8A-SM-2TF61	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903286
Liver	GTEx Tissue Gene Expression Profiles 2023	1.0	2.1572
HEB	MotifMap Predicted Transcription Factor Targets	1.0	null
Mitochondrial tricarboxylic acid cycle enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.682
VZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30657
BRD-K12089436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01939
GTEX-N7MS-0011-R5a-SM-2HMK8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37401
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.20503
Adrenal gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.31
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R7A-SM-2HMJP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08434
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE116930,GSE116935_3_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PWO3-0011-R6A-SM-2I5F3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935524
U2 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.903
E2F6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nifurtimox-2908	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.86635
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27me3_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.988968
SKRC31	DepMap CRISPR Gene Dependency	1.0	2.09457
exisulind-309	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
scopoletin-3131	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_MCF10A_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.1862
GTEX-RVPV-0011-R3A-SM-2TF63	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05895
BRD-K69744558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6798
virion part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.504318
REST_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU503	DepMap CRISPR Gene Dependency	1.0	2.00624
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.812
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.69117
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCIH209	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43784
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_20_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
ROS-50	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.7599
GTEX-X4XX-0011-R6B-SM-46MWP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69492
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02813
Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y0-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNF14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39625
GATA2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
SNU407	CCLE Cell Line Gene Mutation Profiles	1.0	null
IM9	DepMap CRISPR Gene Dependency	1.0	5.49392
H3K4me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
REST_Panc1_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE120612_7_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195743_3_v_2_lhx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0318
QSOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72249
CL14	CCLE Cell Line Gene Mutation Profiles	1.0	null
GSE160817_0_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A8YO-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4387713-supp_gad.255984.114_Table_S4.xlsx-S4A-Down_Nanog_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K02087489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24119
ChIP_POU5F1_18700969	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Perturb_13839_OE_Mir200_SRP124784	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.73272
PMC8185471-mmc4.xlsx-D2-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_2_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K96549574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00818
THAP1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN010_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23609
VZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-3.13018
NB1	CCLE Cell Line Gene Expression Profiles	1.0	1.79024
primary auditory cortex (core)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01872
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.49246
BRD-K43639523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39518
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MDAMB468	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.58445
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1	ENCODE Transcription Factor Targets	1.0	null
TP53_01_286	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61269
JHH2	DepMap CRISPR Gene Dependency	1.0	3.16576
kinase activity	GO Molecular Function Annotations 2015	1.0	null
pentetrazol-1408	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN014_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.47335
Viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.037
HOP92	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.52805
deep layers of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00636
GSE202434,GSE202438_3_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4838
VZ in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07415
TCF3-18347094-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.64472
GPKOW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08755
cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.056138
REST_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PC-62-AQ92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265973
MAPK1_knockdown_45_GSE12291	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.80795
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-TSE9-0011-R8A-SM-3DB7R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87762
NFIC_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hematopoietic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.676172
GSE195568_3_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE158431_5_v_1_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
peptidyl-serine phosphorylation	GO Biological Process Annotations 2023	1.0	null
hybridoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.179957
BRD-K36352298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35148
CCNA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07485
BRD-K77246148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4812
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23173
SAP30	ENCODE Transcription Factor Targets	1.0	null
protein kinase activity	GO Molecular Function Annotations 2015	1.0	null
GSE229671,GSE229673_3_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16748
lymphocytic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.115175
Eye cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
head and face region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.930848
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
C75	DepMap CRISPR Gene Dependency	1.0	2.2902
GSE224969,GSE224971_0_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
RB1_KD_GSE50532_624_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Perturb_4964_KO_WWOX_SRP277498	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.90826
obsessive-compulsive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
SHSYSY+RA	BioGPS Cell Line Gene Expression Profiles	1.0	2.41625
BRD-K40485332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12581
BRD-K97865175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03825
hsa-miR-3173-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
fluoxetine_mus musculus_gpl1261 _gds2803	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cerebellar cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.18057
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.2177
SNU1	CCLE Cell Line Gene Mutation Profiles	1.0	null
GSE226316_3_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H630	COSMIC Cell Line Gene Mutation Profiles	1.0	null
6-azathymine-2466	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
carbohydrate derivative binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-NPJ7-0011-R8a-SM-2I3G2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.964886
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.85491
KLF14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	85.0744
extracellular region part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044821
FF-86-NH56_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.445821
DICER1_KO_GDS4504_586_mouse_bone marrow granulocyte-macrophage progenitors	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
NCIH1436	CCLE Cell Line Gene Expression Profiles	-1.0	-1.59288
BRD-K65203256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05262
GSE207611,GSE207612_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ERG-21242973-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4019
GSE126345_11_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.19256
BRD-K04443775	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19482
GSE202434,GSE202438_2_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE214514_1_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE190322,GSE190324_3_v_4_rbm4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120612_4_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.25983
Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K18637162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03447
BRD-K64860451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31353
CAL27	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39722
GSE228992_0_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126345_9_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.899289
PMC11073972-41375_2024_2232_MOESM2_ESM.xlsx-REL-14_CD7_CD1a-_L-IC_DEG-DEG_L2FC_1_0_FDR_0_05_REL	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WL46-0011-R2A-SM-3LK6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49616
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CRCGN017_MCF10A.WT.HP_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.521
GTEX-T5JC-0011-R10A-SM-32PM2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3955
Brain Lower Grade Glioma_LGG_TCGA-HT-A616-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3660	TargetScan Predicted Conserved microRNA Targets	1.0	0.03694
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WI-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF300	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42279
hsa-miR-4526	TargetScan Predicted Conserved microRNA Targets	1.0	0.085563
GTEX-XLM4-0011-R3B-SM-4AT6E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32143
hsa-miR-544	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
H3K27me3_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.768973
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.907348
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.63321
GTEX-S7SE-0011-R1A-SM-2XCDE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17793
Lung squamous cell carcinoma_LUSC_TCGA-18-4083-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE211983_1_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
tic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.701124
PMC5630028-supp_gr.220533.117_Supplemental_File_S9_TCGA_mutation_data.xlsx-SMGs_in_TP53_mutant_tumors-Unnamed_26_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
Eye-retinal bipolar neuron	Tabula Sapiens Gene-Cell Associations	1.0	1.37032
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.870726
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10316
MDAMB157	DepMap CRISPR Gene Dependency	1.0	2.34753
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.657953
PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_down-regulated_in_Myc_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202434,GSE202438_12_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.504
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.34268
hsa-miR-324-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.37496
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.91448
CPC-N	GDSC Cell Line Gene Expression Profiles	1.0	1.78319
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H4K20me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
amygdala	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46784
INSM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.375
Lung squamous cell carcinoma_LUSC_TCGA-O2-A52S-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-7141-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050654
BRD-K48629186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32082
HEC59	CCLE Cell Line Gene Mutation Profiles	1.0	null
CRCGN009_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.57768
ETV5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10585
BRD-K46942548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70905
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.360437
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.8932
Calcium	HMDB Metabolites of Enzymes	1.0	null
hsa-miR-3127-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
adult stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057482
mononuclear phagocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071425
YWHAB	Hub Proteins Protein-Protein Interactions	1.0	null
dantrolene-3978	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K96101240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46496
Weight Loss	CTD Gene-Disease Associations	1.0	1.06625
GSE216043_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF263	ENCODE Transcription Factor Targets	1.0	null
non-growing cell tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.075
GSE210101,GSE210114_8_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235550_2_v_0_hspa9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZMPSTE24_Deficiency_GDS3775_506_mouse_Embryonic fibroblasts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE152441,GSE152442_6_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-3135	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
REST_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ7-0011-R5a-SM-33HBK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865691
DC-93-NP78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.485573
BRD-K53900606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08935
BRD-K87602457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0555
Prostate adenocarcinoma_PRAD_TCGA-V1-A8WV-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_10_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BE-71-AV63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.661442
VZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.24167
GTEX-QVJO-0011-R8A-SM-447C7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.993751
transferase activity	GO Molecular Function Annotations 2015	1.0	null
Serine/threonine/dual specificity protein kinase, catalytic  domain	InterPro Predicted Protein Domain Annotations	1.0	null
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.30371
CAS1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.08419
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.700527
CRCGN015_MCF10A_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7166
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.4956
Perturb_8722_KD_HNRNPC_ERP012958	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.80182
PMC12661646-dmm-18-052290-TableS8.xlsx-Table_S7_related_to_Fig5D-Fig_5D_-_overlap_between_genes_differentially_expressed_in_presence_absence_of_FOXP2_with_cerebellar_organoid_data_FOXP2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE131377_4_v_2_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5630028-supp_gr.220533.117_Supplemental_File_S9_TCGA_mutation_data.xlsx-SMGs_in_TP53_mutant_tumors-Unnamed_31_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.951858
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
portal vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.469211
SET	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19983
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.906544
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217363_6_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE188870,GSE188871_4_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055575
CRCGN016_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.93445
CENPJ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62373
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	4.06839
VZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.927088
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
PMC7064337-elife-51373-supp1.xlsx-EZH2_targets_shPHF19-List_of_2084_genes_marked_by_EZH2_ChIPseq_after_PHF19_KD_shPHF19_AR	Rummagene Transcription Factor Associations 2026	1.0	null
VIIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04324
GSE152441,GSE152442_0_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
adenyl ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
GSE110268_2_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.02595
GSE142684_2_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NPJ8-0011-R7a-SM-2HMJV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830833
COV644	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.825421
hsa-miR-2278	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
GSE156115_2_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
N-phenylanthranilic acid-317	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
brain_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.77887
cisplatin_mus musculus_gpl339_gse6206	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
inner CP in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.901405
furosemide-3197	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RU72-0011-R6A-SM-2TF71	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27539
Embryonic structure	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.172
CHD2	ENCODE Transcription Factor Targets	1.0	null
CTCF_GM12873_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146982_7_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
skeletal muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.082601
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4595011-pgen.1005555.s001.xlsx-BPTF_UP-regulated-Gene_name_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J9-A52B-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.476
GSE210101,GSE210114_1_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	1.0	1.452
GSE101239_5_v_0_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE110178_4_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
levothyroxine sodium-3249	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2975-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STARD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20688
GTEX-WVLH-0011-R7A-SM-3MJFB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852442
CRCGN011_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92035
DNAJC2-21179169-NT2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBQLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21238
H3K27me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
dorsalstriatum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.966948
Perturb_17701_KO|KD_Pds5a|Stag1_SRP365503	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	18.3468
Mitochondrial isocitrate dehydrogenase complex (NAD+)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.754
Basal ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.086
IMR32	CCLE Cell Line Gene Expression Profiles	1.0	2.11721
hsa-miR-3649	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-A7CW-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38114
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
hsa-miR-23a-3p	MiRTarBase microRNA Targets	1.0	null
CHD4-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
fluorocurarine-6083	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
movement disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.251366
CRCGN016_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6068
Central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.172
seminal plasma	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.224398
GSE232631_4_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.805068
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7427
BRD-K73695595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49317
hsa-miR-324-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GTEX-WZTO-0011-R1B-SM-3NMAR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00777
teratocarcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.825529
CB-87-RB49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.23146
LI7	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73708
Ovarian Serous Adenocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
GTEX-Q2AG-0011-R1A-SM-2HMJI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50382
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.687592
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K50216176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3996
H4K20me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE210682_2_v_1_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
CRCGN009_HEPG2_24H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.7934
GSE75976_3_v_6_abl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GAMG	CCLE Cell Line Gene CNV Profiles	1.0	1.53365
GSE132313_1_v_0_fosl2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTF2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5931
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VIIIA	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.995007
primary visual cortex (striate cortex, area V1/17)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.77825
GSE88819_3_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Multisite chronic pain	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.830103
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.63629
inferior olivary complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.983414
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
KDM4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15197
BRD-K72439355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50868
immunoglobulin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.164542
GSE149035_7_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
TRIM28	ENCODE Transcription Factor Targets	1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
calcium/calmodulin-dependent protein kinase activity	GO Molecular Function Annotations 2025	1.0	null
OVK18	CCLE Cell Line Gene Mutation Profiles	1.0	null
BRD-K28429328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06076
BRD-K44833533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97798
Brain Lower Grade Glioma_LGG_TCGA-HT-A5R7-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
temporal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
hsa-miR-4536	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
MEWO	CCLE Cell Line Gene Mutation Profiles	1.0	null
BRD-K76067434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00594
ME-31-RM40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.525996
GSE94814_2_v_3_reck_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RPMI-8226	COSMIC Cell Line Gene Mutation Profiles	1.0	null
merbromin-3700	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
IALM	CCLE Cell Line Gene Expression Profiles	-1.0	-1.89607
ZNF133	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08724
VIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.95743
USF2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
alfaxalone-6514	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K72681425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72615
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SU-DHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01511
Perturb_2016_KO_Hdac3_SRP360955	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE199255,GSE199356_6_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K64577478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32446
CRCGN009_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.11995
JHOM2B	CCLE Cell Line Gene Expression Profiles	-1.0	-2.4225
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HMGN3	ENCODE Transcription Factor Targets	1.0	null
8505C	DepMap CRISPR Gene Dependency	1.0	2.57289
Perturb_14731_KD_SUPT6H_SRP181929	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
EWSR1_02_167	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.62041
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.06928
hsa-miR-4265	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
BRD-K11008696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24285
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.79679
KMBC2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45964
WC-16-IR43_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.430238
BRD-K94401439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04602
TCF12_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JHH-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.835824
primary auditory cortex (core)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.29892
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Asymmetric synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.429
BRD-K67856917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1591
CRCGN015_HEPG2_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.80528
SW1710	CCLE Cell Line Gene Expression Profiles	-1.0	-2.07433
BRD-K66802550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06215
VMCUB1	CCLE Cell Line Gene Mutation Profiles	1.0	null
MDA MB435	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.863769
BRD-K16940345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21225
REST_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_keratinocyte_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.75298
PMC3636213-pgen.1003459.s012.xlsx-Sheet1-KD_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
bone cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070175
H3-3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00642
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE116894_1_v_0_tle3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inner CP in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.5183
cellular process	GO Biological Process Annotations 2015	1.0	null
cerebellar cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.43191
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8330021-13058_2021_1455_MOESM8_ESM.xlsx-MSC_HEATMAP-Unnamed_0_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
SK-MEL-24	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16548
testis	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K27me3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4447	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
BRD-K61078510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33781
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4326	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148200_0_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K97183783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04692
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057987
CRCGN015_HEPG2_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.01035
BRD-K35681049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16786
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.07383
blood cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069826
GSE136894_2_v_3_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K75900642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15466
BE-92-TW08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211717
HS698T	CCLE Cell Line Gene Mutation Profiles	1.0	null
modulation of chemical synaptic transmission	SynGO Synaptic Gene Annotations	1.0	null
17210682-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
Perturb_15708_KD_Ctcf_SRP173291	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.5026
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.38885
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5751-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH522	DepMap CRISPR Gene Dependency	1.0	2.00356
clozapine-4453	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Synapse	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
plasma membrane	GO Cellular Component Annotations 2015	1.0	null
MDAMB435S	CCLE Cell Line Gene Mutation Profiles	1.0	null
KYSE30	CCLE Cell Line Gene Mutation Profiles	1.0	null
organelle part	GO Cellular Component Annotations 2015	1.0	null
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WZTO-0011-R7B-SM-4E3IS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09767
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CIAPIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09641
BRD-K33757887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75334
BRD-K81949875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45659
GADD45B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09926
BRD-K63998843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27553
PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-SOX2-Unnamed_1_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
SKNBE2	CCLE Cell Line Gene Expression Profiles	1.0	1.76957
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_POU5F1_18347094	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
HS698T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48584
QGP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38573
hsa-miR-103a	TargetScan Predicted Conserved microRNA Targets	1.0	0.159923
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.30416
GTEX-N7MS-0011-R1a-SM-2HMJG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26868
GSE226770_1_v_6_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VMRCLCD	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34886
Acute Myeloid Leukemia_LAML_TCGA-AB-2877-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-0011-R10A-SM-3DB7O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01861
abnormal cecum morphology	IMPC Knockout Mouse Phenotypes	1.0	null
H3K27me3_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AB-82-EP26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.476729
PMC8384902-mmc6.xlsx-DEG_ASCL1_3TF_shared-GeneSymbol_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
BRD-K42971210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23158
CRCGN015_MCF10A.TP53.M_24H:P16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0121
SHSY5Y	CCLE Cell Line Gene Expression Profiles	1.0	1.43132
Perturb_4146_KO_Bcl11a_SRP334609	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-16.3161
BRD-K63626200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01521
Perturb_7499_KD_EP300_SRP193326	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K18645499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23953
primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.52408
23132-87	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE211262,GSE211263_0_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1954	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.844508
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_x_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
umbilical cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.083181
GSE221539_1_v_0_lrrc10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NPJ7-0011-R1a-SM-3GACT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06643
T47D	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.765682
FAM200B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5198
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN008_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0616
GSE123502,GSE123504_1_v_0_chd4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cerebellar cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.19636
Lung squamous cell carcinoma_LUSC_TCGA-34-5927-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NANOG_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
glibenclamide-1546	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4072
Perturb_1188_KD_BCL6_SRP187038	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	17.6655
GSE142684_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15163
BRD-K94506829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44901
H3K4me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-NPJ7-2726-SM-2I3FT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16801
BRD-K68544484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16759
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05921
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_16_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
SLR26	DepMap CRISPR Gene Dependency	1.0	2.95142
H3K27me3_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PANC1005	DepMap CRISPR Gene Dependency	1.0	2.1581
hsa-miR-4738-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
Lung squamous cell carcinoma_LUSC_TCGA-NK-A5D1-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17992
pyelonephritis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.455224
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K99455613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31932
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25058
GATA2	ChEA Transcription Factor Targets	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.962661
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.853732
W-13-440	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE169152_5_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5118
cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076066
OVCAR4	CCLE Cell Line Gene Mutation Profiles	1.0	null
HSP90AB1	Pathway Commons Protein-Protein Interactions	1.0	null
GYG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04847
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0011-R7A-SM-2XCDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66376
inner CP in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07416
GTEX-NPJ8-0011-R8a-SM-2HMLG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994
GTEX-PVOW-0011-R5A-SM-32PL7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21929
GSE90019,GSE90020_5_v_2_phf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
plasma membrane	LOCATE Curated Protein Localization Annotations	1.0	null
Stat5a::Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.674
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A556-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11193738-41467_2024_48647_MOESM8_ESM.xlsx-Data_S5-Data_S5_HNF4A-bound_gene_targets_identified_from_ChIP-Seq_in_hepatic_cells_D8_Hep_and_HepG2_cells_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
Autonomic nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.406
ZIC5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	80.0023
POLR2A	ENCODE Transcription Factor Targets	1.0	null
phosphate-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.79622
KP1N	DepMap CRISPR Gene Dependency	1.0	3.89284
BRD-K58066822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05197
USF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOLT-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K21167361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20973
HCC1171	CCLE Cell Line Gene Expression Profiles	-1.0	-2.52724
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Long QT syndrome 14	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.737
GSE165579_0_v_1_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NPJ8-0011-R5a-SM-2HMJY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907937
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A4IH-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GSE111247_2_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
Perturb_2756_KD_RBMS1_SRP254632	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.66416
BRD-K42435237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28517
JMSU1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.78241
CRCGN010_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.43442
GTEX-X261-0011-R8A-SM-4E3I5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830262
CADOES1	CCLE Cell Line Gene Expression Profiles	1.0	1.68195
Heart Defects, Congenital	CTD Gene-Disease Associations	1.0	1.03827
hsa-miR-16-5p	MiRTarBase microRNA Targets	1.0	null
Brain ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.31
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4776-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.293524
t-lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.170632
KP-N-YN	GDSC Cell Line Gene Expression Profiles	1.0	1.67447
GSE233647_4_v_6_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
phenazone-1989	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-KV-A6GE-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K16064200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50535
increased freezing behavior	MGI Mouse Phenotype Associations 2023	1.0	null
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R4A-SM-2HMKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39316
Brain Lower Grade Glioma_LGG_TCGA-FG-A713-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.36757
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE182770,GSE182784_0_v_1_chd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3906982-1471-2164-14-830-S1.xlsx-Sheet1-Table_S1_HOXC9-responsive_genes_HOXC9	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PGC-1alpha_Deficiency_GDS4904_310_mouse_Aged gastrocnemius muscle - 10 weeks	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Regular attendance at a religious group	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.752288
GTEX-P44H-0011-R5A-SM-2XCEX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59266
Perturb_8385_KD_USP22_SRP213120	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE202434,GSE202438_15_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02515
GSE150134_1_v_0_fluorouracil_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-195-5p	MiRTarBase microRNA Targets	1.0	null
clopamide-1605	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.225267
CRCGN014_HEPG2_3H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.45495
piroxicam-1405	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
laterodorsal part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.5013
MIR122_OE_GDS3470_573_human_Embryonic stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051879
NUGC-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.83671
bladder	GTEx Tissue Gene Expression Profiles	-1.0	-1.19586
GTEX-WWYW-0011-R6A-SM-3NB3G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87748
HEC-1-A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.89255
PU.1-20513432-BCELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CPEB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17118
GSE110038,GSE133995_3_v_0_hic1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111660_1_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QVJO-0011-R6A-SM-2S1QN	GTEx Tissue Sample Gene Expression Profiles	1.0	2.18881
hsa-miR-378	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
TEAD4_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K72424071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86426
SK-N-SH cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.883
BRD-K10812033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28242
REST_Panc1_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE143743_0_v_2_c9orf72_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC10055465-media-2.xlsx-ST15-Supplementary_Table_15_Bonferroni-significant_results_of_MAGMA_gene_based_association_analyses_EA_-_p_2_67e-06_0_05_18702_genes_AA_-_p_2_63e-06_0_05_18976_genes_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XMD1-0011-R10A-SM-4AT4A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838679
BRD-K99250186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.268
Caudate nucleus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.086
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-378i	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
intracellular part	GO Cellular Component Annotations 2015	1.0	null
BRD-K56057104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38858
posteroventral (inferior) parietal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.844483
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
ANXA9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6398
LAN-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.973
GTEX-XMD1-0011-R5A-SM-4AT47	GTEx Tissue Sample Gene Expression Profiles	1.0	0.993965
ISHIKAWAHERAKLIO02ER	CCLE Cell Line Gene Mutation Profiles	1.0	null
EIF2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02647
Perturb_11479_KO_Ring1_SRP321271	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	15.8136
GSE145430_0_v_1_zmat3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.27057
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70H-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202434,GSE202438_10_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.55709
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-PK-A5HA-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.060362
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-CA-geneName_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
cefsulodin-3328	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
dimenhydrinate-2400	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5630028-supp_gr.220533.117_Supplemental_File_S9_TCGA_mutation_data.xlsx-SMGs_in_TP53_mutant_tumors-Unnamed_36_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE126345_4_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.514319
GSE202434,GSE202438_9_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Posterior silk gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.75
Perturb_7412_KD_Nsun2_SRP018786	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
hsa-miR-4710	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
BRD-A44438286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03912
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8905236-mmc2.xlsx-Table_S10-Table_S10_Differentially_regulated_genes_in_SPI1_high_vs_low_group_in_CGGA_GBM_dataset_SPI1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3022822-1471-2164-12-11-S6.XLS-ES_enriched_list-Additional_File_6_Human_embryonic_stem_cells_genes_that_are_SOX2_targets_in_GBM_cells_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
NCI 460	BioGPS Cell Line Gene Expression Profiles	1.0	1.43209
SK-N-BE(2)C cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.822
Diastolic blood pressure	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.830103
Perturb_3969_KO_S100A2_SRP344838	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Claustrum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.627
BRD-K04786080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21973
GSE152441,GSE152442_0_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
pbmc cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.01506
GSE158431_5_v_7_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.05718
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.53713
GSE199255,GSE199356_3_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.678644
GSE94849_3_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.874413
Lung squamous cell carcinoma_LUSC_TCGA-96-A4JK-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.172
inflammatory bowel disease	GWASdb SNP-Disease Associations	1.0	0.406111
EC-62-OE64_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.600043
BRD-K40474424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24892
abnormal uterus morphology	IMPC Knockout Mouse Phenotypes	1.0	null
PMC8755441-mmc3.xlsx-IRF3-signif-Symbol_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.2404
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.1966
Insular cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.965
GTEX-XOTO-3026-SM-4B65M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.271
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.522
BRD-K44921612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45028
GSE101336_1_v_2_decitabine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH2172	CCLE Cell Line Gene CNV Profiles	-1.0	-1.91541
connecting stalk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081328
Autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
hsa-miR-4267	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
hypoglossal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07392
SG in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.969019
BRD-K39348592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51838
nifenazone-7314	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K51787437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40997
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.467
CRCGN015_HEPG2_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.94172
H4K20me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-1909	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
BL41	CCLE Cell Line Gene Mutation Profiles	1.0	null
GTEX-X585-0011-R5A-SM-46MVI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3222
hsa-miR-30b-5p	MiRTarBase microRNA Targets	1.0	null
BRD-K61335814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18056
CRCGN017_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7152
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.896018
glibenclamide-3163	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE148252_5_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.03805
proctitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.852402
H3K4me1_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55E-0011-R7A-SM-2TC5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09789
GTEX-UTHO-3026-SM-3GAFB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20861
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.431
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.852805
FLI1	MotifMap Predicted Transcription Factor Targets	1.0	null
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.825421
GTEX-P44H-0011-R4A-SM-2XCEW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0196
BRD-K47471281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03985
spinalcordlower	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.10748
HDAC2	ENCODE Transcription Factor Targets	1.0	null
CRCGN011_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.6691
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
myeloid progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063013
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K73494324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8264
lymphoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.754124
Perturb_5102_KD_Ep300_SRP225823	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GTEX-QVUS-0011-R10A-SM-3GIK3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.969423
BRD-K95963125	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13186
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MS-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IGFBPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00539
amodiaquine-3186	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A39521712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14931
VZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.55505
GSE164874_5_v_0_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LK-01A-12R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H524	GDSC Cell Line Gene Expression Profiles	1.0	2.34297
GSE171401_1_v_0_adnp_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF667	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3235
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27669
SALL4-28974232-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K98790311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8973
GSE210580_3_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057512
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Congenital mirror movement disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.239
hsa-miR-188-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.283838
eye cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSU	CCLE Cell Line Gene CNV Profiles	1.0	2.90522
Brain Lower Grade Glioma_LGG_TCGA-HT-7607-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.919559
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.3974
Sarcoma_SARC_TCGA-WK-A8XT-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.05638
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YY-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LRRC58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25415
oxytetracycline-3170	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Caudatenucleus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.91532
AA-22-UI44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.897569
BRD-K45498945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08125
GSE201239_3_v_2_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Sleep disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.812
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	80.3497
DNAJC2-21179169-NT2-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K90694955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23819
CRCGN015_HEPG2_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.06799
BRD-K67131822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30347
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31307
CRCGN017_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9009
BRD-K28057105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17
BRD-K37684893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15429
H2BK120ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCI-H2461	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.22912
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE140936,GSE140938_2_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
CORL23	DepMap CRISPR Gene Dependency	1.0	4.24359
GSE226316_4_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126345_2_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BL5675 (ANKRD26)	NURSA Protein Complexes	1.0	null
GSE217541,GSE217543_3_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZR75_1	BioGPS Cell Line Gene Expression Profiles	1.0	0.914746
marrow cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063345
CRCGN015_HEPG2_48H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.32971
EZH2-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-QMR6-0011-R8A-SM-32PKJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988167
flufenamic acid-316	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FUOV1	CCLE Cell Line Gene CNV Profiles	1.0	1.4568
MM-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.885
hematopoietic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061313
BRD-K62312047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47047
KLF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	80.3643
GSE187006_3_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
INIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46765
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.873249
SP4	ENCODE Transcription Factor Targets	1.0	null
ZSCAN21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2006
HS944T	CCLE Cell Line Gene CNV Profiles	1.0	1.72188
colorectum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.344818
BRD-K18402224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01016
TAL1	MotifMap Predicted Transcription Factor Targets	1.0	null
Perturb_17431_KO_Tcf7_SRP096345	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
RFXANK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87086
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.81378
IGR-37	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09706
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.990998
HCT116	Achilles Cell Line Gene Essentiality Profiles	1.0	1.27772
abnormality of the abdomen	GWASdb SNP-Phenotype Associations	1.0	0.059866
gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.051109
lung	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE195786_0_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
VIIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.892976
Primary B cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.986516
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053663
adenyl nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
GSE216043_10_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
dengue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.462394
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-R55E-0011-R6A-SM-2TC5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43351
GSE86507,GSE86509_3_v_5_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
culture medium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.192849
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.929939
PCI-4B	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SPI1_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5312_KD_PPP3CC_SRP275579	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
CRCGN014_HEPG2_3H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83793
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.42004
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14029
peptidyl-serine modification	GO Biological Process Annotations 2023	1.0	null
DDX24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.06194
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42608
CCDC28B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28707
Hippocampus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.31
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
hydrastine hydrochloride-6011	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
megestrol-6468	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE126127_5_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:B07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.91482
u87	HPA Cell Line Gene Expression Profiles	-1.0	-0.969415
CRCGN015_MCF10A_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.3136
Right nucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.664
lidoflazine-3201	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
TUHR10TKB	DepMap CRISPR Gene Dependency	1.0	4.92637
HNF4A	ChEA Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-8358-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K48583488	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13888
shsy5y	HPA Cell Line Gene Expression Profiles	1.0	0.968806
BRD-K47673408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61623
GSE232218_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
proglumide-3972	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE126402_1_v_6_tal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1128
BRD-K75413392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.49725
H3K27me3_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3719
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.489695
CRCGN015_HEPG2_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.35529
BRD-K43936062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33069
496100507_FWM_dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.06704
viral genome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.587199
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050952
BRD-K29039402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08031
PMC12198403-41398_2025_3437_MOESM1_ESM.xlsx-S15-Table_S15_MR_results_of_significant_candidate_genes_and_neurological_disease_outcomes_in_IVW_or_Wald_ratio_methods_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-6669-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CLPP_KO_GDS4791_543_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
other organism part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.103829
colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.260184
human immunodeficiency virus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.613965
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Cognitive disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.539
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPV-0011-R5A-SM-2TF69	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15267
CRCGN015_HEPG2_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.40529
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.55969
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34991
USF1	ENCODE Transcription Factor Targets	1.0	null
phosphorylation	GO Biological Process Annotations 2015	1.0	null
CRCGN017_MCF10A.TP53.M_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.0447
Lung adenocarcinoma_LUAD_TCGA-55-6969-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8015-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GSE229468,GSE229471_0_v_3_znf587_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-23-FM46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.11806
Cardiomyopathy, Dilated_Myocardial tissue_GSE3586	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.97017
BRD-K07276022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32211
GSE210101,GSE210114_1_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053785
cerebral lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CRCGN012_HEPG2_24H:J21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12789
BRD-K50140257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49533
mRNA_POU5F1_20526341	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
viral replication complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.242076
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE95077_1_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CLINDAMYCIN-PO4	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2724
t-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.779816
PF382	DepMap CRISPR Gene Dependency	1.0	2.86668
fludroxycortide-4702	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K36923996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37943
PMC8202205-NIHMS1706275-supplement-Table_S3.xlsx-Day_4_GATA6-dependent_genes-GATA6-dependent_mRNA_expression_Day_4_Definitive_Endoderm_FDR_0_05_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K68298468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06706
Crx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.5793
BRD-K74712962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69173
Rectum adenocarcinoma_READ_TCGA-DY-A1H8-01A-21R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ca9-22	GDSC Cell Line Gene Expression Profiles	-1.0	-2.02147
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.893072
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2937-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4758-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
POU5F1-18347094-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE171837_3_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
CRCGN014_HEPG2_3H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.60134
KYO1	DepMap CRISPR Gene Dependency	1.0	4.24342
MDA-MB-468	GDSC Cell Line Gene Expression Profiles	-1.0	-1.97281
GSE94849_6_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Enterocyte progenitor cell_Small intestine_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE127790_4_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MDA-MB-435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.99849
QE-18-WG07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221301
GSE162892_3_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K62541003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.681
cerebellar cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.61861
BRD-K25330450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21223
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.36861
GSE216273,GSE216292_14_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15539
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.962661
Perturb_8723_KD_HNRNPC_ERP012958	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.34824
CRCGN016_MCF10A.TP53.M_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41877
fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07104
BRD-K58728497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19813
K562	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.13641
hsa-miR-378b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
BRD-K75453159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27822
vinburnine-6802	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54532
H3K4me1_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
pirenperone-5639	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE234289_5_v_0_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Refractive error	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.33979
Distal dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.708
RCOR1	ENCODE Transcription Factor Targets	1.0	null
59M	DepMap CRISPR Gene Dependency	1.0	2.33746
DCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24696
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE174498,GSE174500_3_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SU-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K84423439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11921
GTEX-WZTO-0011-R4A-SM-3NMC7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22733
H3K9me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8816717-mmc2.xlsx-TgCRND8_P113-Unnamed_2_STAT2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TIMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5068
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
ZNF281	ChEA Transcription Factor Targets	1.0	null
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Testicular cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
UMUC13	DepMap CRISPR Gene Dependency	1.0	2.70493
outer portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08031
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.04591
REST_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
Mitotic spindle pole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.924
BRD-K83297764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30203
CRCGN015_MCF10A_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.17967
hsa-miR-4722-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
hsa-miR-4649-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleus	LOCATE Curated Protein Localization Annotations	1.0	null
HEC1A	CCLE Cell Line Gene Mutation Profiles	1.0	null
leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.083909
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-68-8251-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K57042334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07714
GSE146982_7_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE160817_5_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K60132279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01011
peritoneal fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.307889
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.51408
GSE143499_0_v_1_gata6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T6MN-0011-R4A-SM-32QPG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.905802
PMC11024925-mmc3.xlsx-Gene_lists-MV411_FOS_ChIP_and_RNA_overlap_after_10_nM_Gilteritinib_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1806	CCLE Cell Line Gene CNV Profiles	-1.0	-1.85911
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Down_bins-Down_bins_loosing_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AG-0011-R8A-SM-2HMK5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.885643
NCI-H835	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K74103290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55186
mRNA_ATF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32544
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	115.637
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.61749
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-WT-gene_symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
SCC4	DepMap CRISPR Gene Dependency	1.0	3.2081
BRD-K73539077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09764
Gastroesophageal reflux disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.535
macrophage	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.213291
Pyramidal CA1 cell_Hippocampus_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
hsa-miR-4708-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.045136
tretinoin_homo sapiens_gpl6244_gds4180	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nes	HPA Cell Line Gene Expression Profiles	1.0	1.03289
GSE240896,GSE240899_10_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.20552
GSE119498_2_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IMR-5	GDSC Cell Line Gene Expression Profiles	1.0	2.2256
fluoxetine_mus musculus_gpl1261_gds2803	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CE-18-CG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215198
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.34411
GTEX-NL4W-0011-R5a-SM-2I3GD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11137
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.7397
CRCGN015_MCF10A_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7987
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.309
CRCGN014_HEPG2_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.01149
TE-12	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K59657378	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.40932
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.21167
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE202434,GSE202438_2_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormality of the large intestine	GWASdb SNP-Phenotype Associations	1.0	0.288217
primary bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044889
CRCGN015_MCF10A.WT.HP_24H:P17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17031
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTIP_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
inflammatory bowel disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.682294
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WW-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JL1	DepMap CRISPR Gene Dependency	1.0	2.29662
MAK16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07483
HCT15	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.08881
GTEX-WWYW-0011-R1A-SM-3TW8G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27229
GTEX-X585-0011-R1B-SM-46MVE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58736
CTB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
REST_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AB-18-YN11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225919
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.87348
nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053981
GSE152441,GSE152442_6_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.378
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adenocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053823
BRD-K09468701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25931
mercaptopurine-334	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Familial hypocalciuric hypercalcemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE152937_12_v_1_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180185_7_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QVJO-0011-R4A-SM-2S1QL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07143
rectum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.618603
GSE176008_0_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHML	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01178
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07839
pontobulbar body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.35195
PMC5303304-13073_2017_407_MOESM4_ESM.xlsx-mycn-sy5y-se_single_24DMSO_vs_2-Table_S3_Genes_differentially_expressed_by_24h_RA_and_48h_Dox_co-treatment_DE_comparison_with_SY5Y-MYCN_control_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K11566982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38066
UBTF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.89255
genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04553
SKCO1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.0204
CORL311	CCLE Cell Line Gene Expression Profiles	1.0	1.62167
NCIH69	CCLE Cell Line Gene Expression Profiles	1.0	1.35469
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9607
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
BRD-K56987347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03062
CRCGN016_MCF10A.WT.HP_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.86531
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
protein binding	GO Molecular Function Annotations 2015	1.0	null
brain_3c	HPA Tissue Sample Gene Expression Profiles	1.0	1.7367
GNA11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05946
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73637411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59258
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.927405
SF268	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.99849
NB6	GDSC Cell Line Gene Expression Profiles	1.0	1.70321
cerebellar cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11094
PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_12_in_RNA-seq_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6057
Perturb_5311_KD_NFATC3_SRP275579	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
BRD-K49050984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10814
CHP-134	GDSC Cell Line Gene Expression Profiles	1.0	3.15465
HUPT3	DepMap CRISPR Gene Dependency	1.0	3.36124
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.275801
GTEX-N7MT-0011-R7a-SM-2I3FZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54442
Perturb_10155_KD_ZRSR2_SRP265290	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.71442
LOUCY	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TCF3	ChEA Transcription Factor Targets	1.0	null
SP1	ENCODE Transcription Factor Targets	1.0	null
GSE226316_0_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TPM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35841
BRD-K52254237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35148
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.773
GSE115364_0_v_1_idh3a_human	RummaGEO Gene Perturbation Signatures	1.0	null
cervix uteri	GTEx Tissue Gene Expression Profiles	-1.0	-0.82545
mRNA_POU5F1_16518401	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
Regular attendance at a gym or sports club	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.922185
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.0304
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5001-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.70275
mebeverine-3193	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47369
GSE234334,GSE234336_1_v_0_zhx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065001
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.962661
ES-I3 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-2.0876
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RQ-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.WT.HP_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.49495
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GRIPAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02279
provirus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.620529
GTEX-OXRN-0011-R10A-SM-2I5GC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05416
hsa-miR-3545-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
REST_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NANOG	ENCODE Transcription Factor Targets	1.0	null
BRD-K02688026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14535
Perturb_17767_KO_Prdm16_SRP238935	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.60429
THOC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59575
Perturb_15352_KO_DND1_SRP319950	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.66873
GTEX-QVUS-0011-R8A-SM-3GAD7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.969396
GTEX-N7MT-0011-R5a-SM-2I3G6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5067
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-4.08174
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal cecum morphology	MGI Mouse Phenotype Associations 2023	1.0	null
celecoxib-206	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
occipital lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1755
H3K27me3_CH12.LX_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
hsa-miR-377	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE94814_1_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
REST_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
protein modification process	GO Biological Process Annotations 2015	1.0	null
GSE152441,GSE152442_7_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040542
GSE126345_0_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QDT8-0011-R3A-SM-32PKR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04708
Lung adenocarcinoma_LUAD_TCGA-55-5899-01A-11R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nfatc1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.2798
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZH-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.63333
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.623
BRD-K29420358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25303
CA2 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06692
host cell nuclear part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.242076
pRb_Deficiency_GDS3176_605_mouse_Skin	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
primary auditory cortex (core)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.890232
PMC7021759-41467_2020_14682_MOESM8_ESM.xlsx-Upregulated_Genes-Table_S5_Upregulated_genes_in_MYCN_amplified_neuroblastoma_relative_to_non-amplified_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH2347	CCLE Cell Line Gene CNV Profiles	1.0	1.57273
SDF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6624
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.67677
GTEX-R55E-0011-R8A-SM-2TC66	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849743
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2111
ALX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60578
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10066
Brain Lower Grade Glioma_LGG_TCGA-FG-8181-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
altretamine-6467	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K52379519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20288
BRD-K17133642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22048
PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.31
NCIH446	CCLE Cell Line Gene Expression Profiles	1.0	1.959
DNAJC2	ChEA Transcription Factor Targets	1.0	null
GSE223008_4_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
thalidomide-1411	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null