association dataset threshold value standardized value Ovary GTEx Tissue Gene Expression Profiles 2023 1.0 5.1976 GSE103068_0_v_4_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null ZNF667 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9755 GTEX-P44H-0326-SM-2XCES GTEx Tissue Sample Gene Expression Profiles 1.0 0.95333 Nucleomorph COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.259 NCIH1373 CCLE Cell Line Gene Expression Profiles 1.0 1.91692 Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral part of the lateral habenular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10949 intermediate stratum of 5BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0083 Perturb_17725_KO_Creb_SRP178474 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.80095 SOS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5664 SHKBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28904 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4811-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XYKS-0008-SM-4BRW6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23916 H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Orbital area, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09608 CHD1 ENCODE Transcription Factor Targets 1.0 null GTEX-U3ZN-0626-SM-3DB7U GTEx Tissue Sample Gene Expression Profiles 1.0 1.82509 THAP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.68548 GTEX-NL3H-0011-R6a-SM-2I3G8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2754 C8orf58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77473 SKN-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-S4Z8-0006-SM-3K2AQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.17131 GTEX-WFG7-2326-SM-3GIKV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.911406 GTEX-OXRN-0526-SM-2I5EN GTEx Tissue Sample Gene Expression Profiles 1.0 1.52865 PDZD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8817 Perturb_15284_KO_Trp73_SRP067006 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 BFTC-905 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.68576 GTEX-OIZG-0526-SM-2HMLF GTEx Tissue Sample Gene Expression Profiles 1.0 1.13047 GTEx Skin 20-29 vs 70-79 GTEx Tissue-Specific Aging Signatures 1.0 4.98901 LARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28371 HMGB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11614 SMC3 ENCODE Transcription Factor Targets 1.0 null ETS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08153 TP53BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82255 GSE151612_0_v_7_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-P4PP-0008-SM-48TDV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01678 GTEX-WY7C-0426-SM-3NB3C GTEx Tissue Sample Gene Expression Profiles 1.0 1.59145 H3K9me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XK95-0008-SM-4AT5G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.72293 vestibular nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.852653 GTEX-UPK5-1126-SM-3GAEJ GTEx Tissue Sample Gene Expression Profiles 1.0 2.42309 MYOC_OE_GDS1640_269_mouse_retina GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-5479-01A-31R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF675 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.8047 MYO19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40012 mediodorsal nucleus of thalamus_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.74462 Brain Lower Grade Glioma_LGG_TCGA-RY-A83Z-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of CoPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11332 lung_4a HPA Tissue Sample Gene Expression Profiles 1.0 1.02909 PPARG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.1429 THAP7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76982 GTEX-T6MO-1026-SM-4DM72 GTEx Tissue Sample Gene Expression Profiles 1.0 1.47981 PMC9424213-41467_2022_32537_MOESM5_ESM.xlsx-HeLa_IER3-AS1sh_DEGs-DEGs_in_HeLa_IER3-AS1sh_KD_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null peripheral portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02963 H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null LCTL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49616 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4847-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null thp1 HPA Cell Line Gene Expression Profiles -1.0 -1.00276 POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MN-0011-R10A-SM-32QP7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20151 TBP ENCODE Transcription Factor Targets 1.0 null GTEX-QVJO-0011-R1A-SM-2S1QI GTEx Tissue Sample Gene Expression Profiles 1.0 0.975817 cingulate gyrus, parietal part, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.09733 ASB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43285 H3K27ac_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RBPJL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72889 Taenia tecta, dorsal part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32543 MRPS34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54552 ZBTB7A ENCODE Transcription Factor Targets 1.0 null H3K9ac_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Lobule III, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.06176 GTEX-Q734-0008-SM-48U2I GTEx Tissue Sample Gene Expression Profiles -1.0 -0.948614 Pheochromocytoma and Paraganglioma_PCPG_TCGA-PR-A5PF-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OXRN-0011-R10A-SM-2I5GC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.96986 Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I3-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CD2AP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59837 amygdaloid complex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.998323 GTEX-QEL4-0826-SM-3GAF2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.78464 Perturb_9132_KD_Epas1_SRP049514 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.29064 Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LB-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r10 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16407 lateral terminal nucleus of the accessory optic tract, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25115 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7242-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cortical thickness (min-P) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.752288 POLR2A_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null olivary pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13416 GTEX-RUSQ-0126-SM-47JWV GTEx Tissue Sample Gene Expression Profiles 1.0 1.12478 SNU-C2B COSMIC Cell Line Gene Mutation Profiles 1.0 null 496100543_FWM_probable Alzheimer's disease_TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.75278 H4C12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36844 RNF130 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.08505 GTEX-T5JW-0005-SM-3GADE GTEx Tissue Sample Gene Expression Profiles 1.0 1.54161 C1orf174 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60358 IGF2BP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66289 primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.73606 GP5D COSMIC Cell Line Gene Mutation Profiles 1.0 null NR4A1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.6991 CASKIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29922 primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.947043 NR2F2_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55D-0006-SM-3GIJS GTEx Tissue Sample Gene Expression Profiles 1.0 0.85548 RUNX1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA ChEA Transcription Factor Targets 2022 1.0 null GTEX-Q2AH-2026-SM-2S1PX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.836159 GTEX-RNOR-0011-R4A-SM-3GAD3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.851223 GSE184892_4_v_2_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null DIPK1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9295 GSE151829,GSE151831_7_v_0_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-QMR6-1926-SM-32PL9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.953844 H4K20me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Radial spoke COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.721 fallopian tube GTEx Tissue Gene Expression Profiles 1.0 2.18577 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4988-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null raphe nuclei of medulla Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.10206 TK-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.984476 KINGS-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-X4XY-1026-SM-46MVX GTEx Tissue Sample Gene Expression Profiles 1.0 1.97052 AMH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37957 cuneiform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1034 TRAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.49006 ntera2 HPA Cell Line Gene Expression Profiles -1.0 -0.829838 Lung squamous cell carcinoma_LUSC_TCGA-39-5028-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NOL11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 5.9248 fallopiantube_8e HPA Tissue Sample Gene Expression Profiles 1.0 1.43328 SHISAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68016 NCIH2081 CCLE Cell Line Gene CNV Profiles 1.0 1.58227 Respiratory system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.732 GTEX-Q2AG-0008-SM-48U2K GTEx Tissue Sample Gene Expression Profiles -1.0 -0.879203 GTEX-Q2AG-0011-R9A-SM-2HMJ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02725 P30-OHK COSMIC Cell Line Gene Mutation Profiles 1.0 null OSGIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.78331 GOT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25211 anterior hypothalamic area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1492 DNAAF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65061 PLEKHA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12145 GSE171177,GSE171181_1_v_0_e7107_human RummaGEO Drug Perturbation Signatures 1.0 null CD4_Naive_Primary_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.19071 SG231 DepMap CRISPR Gene Dependency 1.0 4.54406 GTEX-SNMC-0008-SM-4DM5A GTEx Tissue Sample Gene Expression Profiles -1.0 -2.17703 TIM23 mitochondrial import inner membrane translocase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.151 TNFSF12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.19886 SMARCA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29241 r6 part of spinal trigeminal nucleus, pars oralis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.73266 H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WZTO-2926-SM-3NM9I GTEx Tissue Sample Gene Expression Profiles -1.0 -0.915775 EIF4EBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82517 OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34555 GTEX-OOBJ-2626-SM-2I3F6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.841488 periventricular stratum of IC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.14588 medial habenular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02435 GTEX-QDT8-0011-R10A-SM-32PKG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.977515 GSE87412,GSE92423_0_v_4_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null MCM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05929 SG in posterior frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.34471 GSE125007,GSE125008_4_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null NOB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9819 SH3D19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.426 MMRN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40881 Rhox11 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.6907 paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.3018 Brain Lower Grade Glioma_LGG_TCGA-DU-A5TR-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r10 basal plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12386 ALYREF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30908 PMC9434001-Table_1.XLSX-Sheet_1-ZBTB7B_ZBTB7B Rummagene Transcription Factor Associations 2026 1.0 null H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null superficial stratum of r6Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1725 CHP212 CCLE Cell Line Gene CNV Profiles -1.0 -2.72917 RAD51AP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74755 UBB_KO_GDS3906_494_mouse_Testis - 21 Days GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-P44H-0006-SM-2XCFB GTEx Tissue Sample Gene Expression Profiles 1.0 1.11612 posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.35071 GTEX-X585-0008-SM-46MU4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09543 ATP5MF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26872 outer SZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23323 H3K4me1_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A550-01A-61R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JIMT1 CCLE Cell Line Gene CNV Profiles 1.0 1.33486 Spinal nucleus of the trigeminal, oral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22593 H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CLP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15946 H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K79me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A299-01A-21R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFYB-21822215-K562-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GATA6-21074721-CACO-2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-R55G-0826-SM-2TC5U GTEx Tissue Sample Gene Expression Profiles 1.0 1.26191 BMI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51158 EMC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2273 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4355-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50464 posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.37508 JARID1A-20064375-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC11263679-41598_2024_66946_MOESM1_ESM.pdf-13-ZNF213_ZNF213 Rummagene Transcription Factor Associations 2026 1.0 null ENSG00000170846 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78851 SIN3A-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null brain_3c HPA Tissue Sample Gene Expression Profiles -1.0 -2.35577 GTEX-U8XE-0008-SM-4E3K4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.996033 superior rostral gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.62748 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4771-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE129244_0_v_1_lmo2_mouse RummaGEO Gene Perturbation Signatures 1.0 null DICER1_KO_GDS4504_586_mouse_bone marrow granulocyte-macrophage progenitors GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null KLF9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58137 PF-382 COSMIC Cell Line Gene Mutation Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F0-06A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hela HPA Cell Line Gene Expression Profiles 1.0 1.70545 Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SK-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE209598_0_v_3_tgfbr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null r6 part of trigeminal transition zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25473 inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02482 ATP1B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57919 medial habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.84876 FEZF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91097 MOLM-16 COSMIC Cell Line Gene Mutation Profiles 1.0 null DNAJC14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55534 T24 DepMap CRISPR Gene Dependency 1.0 2.97717 POLR2A_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U8XE-0626-SM-3DB8U GTEx Tissue Sample Gene Expression Profiles -1.0 -0.953207 GTEX-SN8G-0226-SM-4DM6B GTEx Tissue Sample Gene Expression Profiles 1.0 1.06673 Uterine Carcinosarcoma_UCS_TCGA-N6-A4VF-01A-31R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S32W-1326-SM-4AD5Q GTEx Tissue Sample Gene Expression Profiles 1.0 4.733 agranular insular cortex (area Iag) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03228 GTEX-UJMC-0726-SM-3GADX GTEx Tissue Sample Gene Expression Profiles 1.0 1.21405 WDTC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52389 H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K36me3_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YK-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RABL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00363 Adrenocortical carcinoma_ACC_TCGA-OR-A5LD-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMIM26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26325 KURAMOCHI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.68323 HOXB13-26457646-LNCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null DICER1_KO_GDS4504_582_mouse_bone marrow granulocyte-macrophage progenitors GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null SKNFI CCLE Cell Line Gene Expression Profiles -1.0 -3.06809 NCI-H2804 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.906718 GTEX-S7SF-0426-SM-3K2B7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.867746 PMC3728595-srep02327-s1.pdf-18-ZMAT1_ZMAT1 Rummagene Transcription Factor Associations 2026 1.0 null CARF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47477 NMUR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.88834 F5 DepMap CRISPR Gene Dependency 1.0 2.15348 FAM177A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63757 KO52 CCLE Cell Line Gene Expression Profiles 1.0 1.38002 MDA-MB-468 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.915874 EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.987591 H3K4me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null COLO-704 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.844129 CTCF_GM12865_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.835879 H3K27ac_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Spinal nucleus of the trigeminal, interpolar part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.59293 FAM171B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43404 GTEX-T2IS-0526-SM-32QP9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.81562 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3MR-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IE-01A-21R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100362_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.32402 H3K27ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NUP214 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38092 POMP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43479 CBARP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7721 Iron status biomarkers (total iron binding capacity) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.609691 ESRRA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38978 SR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.21729 GTEX-WFON-1626-SM-4LVMV GTEx Tissue Sample Gene Expression Profiles 1.0 1.04606 ZNF174 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40686 GSE234340_1_v_7_muc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-QESD-0008-SM-447B2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.866399 H3K27ac_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WL46-0011-R3A-SM-3TW8E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4424 DHDDS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83184 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4714-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CardiacMyocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -2.48152 SLC9A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59097 GTEX-OHPN-0008-SM-4E3HW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57508 TMEM87B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43986 T-47D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.916613 MAGOH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85112 GTEX-O5YT-1826-SM-32PK9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.833259 mantle zone of m2AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.36008 LGMN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.50079 GTEX-P4QR-1026-SM-2I5GP GTEx Tissue Sample Gene Expression Profiles 1.0 1.98387 GTEX-WOFL-0626-SM-3MJG3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.57913 ZBED6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.72652 Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUO-01A-12R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-75-7025-01A-12R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S95S-0008-SM-4AT5M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13841 GTEX-T6MO-0006-SM-32QOU GTEx Tissue Sample Gene Expression Profiles 1.0 1.10686 PSN1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22174 GTEX-TSE9-0011-R10A-SM-3DB7O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01 TTC39C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65964 Superior colliculus, motor related, intermediate gray layer, sublayer b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03478 THP1 CCLE Cell Line Gene CNV Profiles 1.0 1.52629 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4341-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RBM28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13269 PRPS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82946 GSE160817_0_v_8_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null hmc1 HPA Cell Line Gene Expression Profiles 1.0 0.912327 GTEX-OOBK-0005-SM-2YUMG GTEx Tissue Sample Gene Expression Profiles 1.0 0.985876 GTEX-TMZS-0008-SM-47JWM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09092 H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FOXP1-21924763-HESC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AH-0726-SM-2I3EA GTEx Tissue Sample Gene Expression Profiles 1.0 0.950442 HCFC1_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TTLL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86828 FASLG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.10088 FOXA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15058 GTEX-OXRO-0326-SM-33HBM GTEx Tissue Sample Gene Expression Profiles 1.0 1.49841 TMUB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98075 MSI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45606 SIN3A-21632747-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null hsa-miR-320a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 DBNDD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78191 GSE196117_6_v_8_clarithromycin_human RummaGEO Drug Perturbation Signatures 1.0 null NUDT19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20843 mesomere 2 (preisthmus or caudal midbrain) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.72788 superior olivary complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.895191 Lung squamous cell carcinoma_LUSC_TCGA-22-1005-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KDM4C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7052 Axonemal dynein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.611 GTEX-S3XE-0006-SM-3K2AA GTEx Tissue Sample Gene Expression Profiles 1.0 0.830415 PMC12700831-41594_2025_1680_MOESM4_ESM.xlsx-D9_EC_Hits_2_5FC_CRAPomeFilt-Mapped_Gene_Symbol_CENPX Rummagene Transcription Factor Associations 2026 1.0 null HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41878 Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41N-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COX7B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97754 GSE86507,GSE86509_7_v_9_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.55373 GTEX-RWSA-0008-SM-47JYX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.65872 NCI-H196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.841301 FE-82-WB22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.261481 primary auditory cortex (core)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12294 IALM CCLE Cell Line Gene CNV Profiles 1.0 1.57534 GTEX-NL3G-0008-SM-4E3JX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20888 H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K79me2_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FOXA1-25329375-VCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-R55E-0011-R4A-SM-2TC5H GTEx Tissue Sample Gene Expression Profiles -1.0 -0.961466 GTEX-RNOR-2326-SM-2TF4I GTEx Tissue Sample Gene Expression Profiles -1.0 -0.941244 RCOR1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELOVL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91424 GTEX-RVPU-0011-R1A-SM-2XCAI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24783 fallopian tube HPA Tissue Gene Expression Profiles 1.0 2.24804 SLC35B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02703 Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VZ-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ATP2B4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55269 GTEX-WWYW-0011-R6A-SM-3NB3G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.904553 OlfactoryBulb BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.920108 caudal division of IPC (area 39) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23713 GTEX-Q2AG-0011-R4A-SM-2HMKA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.994504 NR2C2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.194 FOXP1-21924763-HESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SNU475 DepMap CRISPR Gene Dependency 1.0 3.44877 UBF1/2-26484160-CHIP-SEQ-HMEC-DERIVED-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Perturb_17729_KO_Creb_SRP178474 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.98606 AQP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68371 RPL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90445 temporal pole, left, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.917105 Sarcoma_SARC_TCGA-DX-A6B7-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DACH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17767 LTBR_INHIBITION - 35 Day_GDS2005_732_mouse_Lymph nodes (MG-430B) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null pontine nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.3163 intracellular organelle LOCATE Curated Protein Localization Annotations 1.0 null membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null CHCHD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69447 salivary gland HPA Tissue Protein Expression Profiles 1.0 1.30122 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4738-01A-02R-1514-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TPR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26852 GTEX-X585-0005-SM-46MV3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.94091 PGK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77099 lateral hemisphere of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.43897 RMDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31133 GTEX-R55D-0926-SM-3GAEU GTEx Tissue Sample Gene Expression Profiles 1.0 1.4667 LAPTM4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.57302 HAE cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.088 GTEX-XUZC-2026-SM-4BRW9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.987509 ZSWIM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41537 HCaRG_OE_GDS2426_711_human_HEK293 kidney cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null CTCF-27219007-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null EZH2 ENCODE Transcription Factor Targets 1.0 null TSEN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22166 POLR3H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85153 H3K4me1_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HMY-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26191 EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.29898 INCA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86595 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A7PW-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.87703 ZNF57 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19387 SP in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00476 TFB2M CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82784 CTSD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13223 GTEX-XAJ8-0126-SM-47JYG GTEx Tissue Sample Gene Expression Profiles 1.0 1.03285 GTEX-QDT8-0011-R3A-SM-32PKR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.829845 GTEX-QDVJ-0626-SM-48U1T GTEx Tissue Sample Gene Expression Profiles -1.0 -0.929975 NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03612 MYBL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66584 CBX3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPINT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.01411 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5001-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH2126 CCLE Cell Line Gene Expression Profiles 1.0 1.70372 A-498 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.18229 GPR161 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.77095 GTEX-RWSA-2026-SM-47JX8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.24733 SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08443 GTEX-S4P3-0008-SM-3NM8R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2561 GTEX-QDT8-0926-SM-32PL2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.35981 GTEX-XMD1-0008-SM-4AT41 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00629 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70N-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GOLPH3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33187 ZSCAN5C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66361 A3/KAW Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.841951 GTEX-QLQ7-0008-SM-447AW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.065 GALNT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12757 H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTSK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03232 496100352_FWM_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.19612 KMRC3 CCLE Cell Line Gene CNV Profiles -1.0 -1.72239 globose nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06909 Bed nuclei of the stria terminalis, anterior division, oval nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03944 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QH-01A-21R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRDM11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94743 GTEX-X5EB-1626-SM-4E3IV GTEx Tissue Sample Gene Expression Profiles 1.0 0.966205 GTEX-OHPL-0008-SM-4E3I9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29212 NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03612 GTEX-Q2AG-0011-R10A-SM-2HMLA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2346 KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.5749 GTEX-NL3H-0008-SM-4E3HU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06116 Sarcoma_SARC_TCGA-DX-A48P-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral part of m2A Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.36045 GSE145311_0_v_3_glutathione_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-O5YT-0008-SM-4E3IQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.77208 ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.981377 Prostate adenocarcinoma_PRAD_TCGA-CH-5766-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE214583,GSE214585_1_v_0_steap1_human RummaGEO Gene Perturbation Signatures 1.0 null Hmx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.9474 r7 part of the nucleus of Roller Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11622 layer 1 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33584 GTEX-QV44-0008-SM-447AX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17832 GTEX-WWYW-3126-SM-3NB39 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0181 H3K27ac_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MZF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30952 posterior cortical nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.6613 H3K4me3_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null EKVX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.20633 inner SZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.856464 H3K4me3_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K36me3_Duodenum Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null DBF4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52203 PF382 CCLE Cell Line Gene Expression Profiles 1.0 1.47129 LARP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85863 KCTD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93172 ADAMTS8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02277 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4971-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null liminal periaqueductal gray of m2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4651 EHD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14153 GTEX-XLM4-0011-R3B-SM-4AT6E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.835292 Perturb_7066_KO_Lrpprc_SRP110979 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.03991 GTEX-P4QR-0008-SM-48TE2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32524 Mesothelioma_MESO_TCGA-MQ-A4LP-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KMS-12-BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.57594 hsa-miR-4429 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12094 H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZKSCAN1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.3099 GTEX-PWOO-0926-SM-2I3EC GTEx Tissue Sample Gene Expression Profiles 1.0 1.19761 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NP-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null retropontine reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62603 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4813-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TGFBR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.91576 Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PZ-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CCDC97 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.19469 GTEX-U8T8-2226-SM-3DB95 GTEx Tissue Sample Gene Expression Profiles 1.0 2.87976 outer SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15532 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A6HN-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZDHHC24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43499 PIM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48861 CTCF_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UMC-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.79167 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YU-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MIIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25121 GTEX-T2IS-0011-R5A-SM-32QP4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4608 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-O5YW-0006-SM-3LK6E GTEx Tissue Sample Gene Expression Profiles 1.0 1.36046 GSE92589_0_v_1_sirolimus_mouse RummaGEO Drug Perturbation Signatures 1.0 null lateral part of preisthmic periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.89949 GTEX-TMMY-0005-SM-33HBN GTEx Tissue Sample Gene Expression Profiles 1.0 1.0192 22RV1 DepMap CRISPR Gene Dependency 1.0 2.36436 GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles 1.0 1.18809 mantle zone of the PBC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.82021 Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GS-01A-12R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-90-7767-11A-01R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ADGRL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71826 MXI1 ENCODE Transcription Factor Targets 1.0 null H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BC-A217-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X15G-0005-SM-3NMDA GTEx Tissue Sample Gene Expression Profiles 1.0 0.917074 HCFC1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-6147-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.43344 LK-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC10933424-41420_2024_1903_MOESM1_ESM.pdf-282-JDP2_JDP2 Rummagene Transcription Factor Associations 2026 1.0 null TXNDC17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01372 PICK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77277 CAL-51 COSMIC Cell Line Gene Mutation Profiles 1.0 null POLR2A_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55F-0011-R6A-SM-2TF4L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01451 POFUT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61032 GTEX-U3ZH-0526-SM-3DB75 GTEx Tissue Sample Gene Expression Profiles 1.0 1.65634 ZHX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.14691 Keratoacanthoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.378 POGLUT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29991 GSE81796_0_v_2_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-OIZG-0008-SM-4E3J2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05885 KP1N DepMap CRISPR Gene Dependency 1.0 3.22413 GTEX-QLQ7-0005-SM-2S1QP GTEx Tissue Sample Gene Expression Profiles 1.0 0.95553 Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A71R-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SE5C-0008-SM-4B64J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70993 PANO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81654 Lung-lung ciliated cell Tabula Sapiens Gene-Cell Associations 1.0 11.8069 GTEX-XMD1-0011-R8A-SM-4AT48 GTEx Tissue Sample Gene Expression Profiles 1.0 1.79654 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4821-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FBXW5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.152 GTEX-V1D1-0826-SM-3P5ZA GTEx Tissue Sample Gene Expression Profiles 1.0 2.414 BHMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27678 EPLC272H CCLE Cell Line Gene CNV Profiles 1.0 1.38287 20174566-TableS1 GeneSigDB Published Gene Signatures 1.0 null GLDC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74597 KLK6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.85229 GTEX-U8XE-1426-SM-3DB8Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.84561 GTEX-UJHI-0008-SM-4IHL1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.911424 lateral habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.56457 GSE188599_1_v_10_resolvin e1_mouse RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4776-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A553-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RU72-0926-SM-2TF6B GTEx Tissue Sample Gene Expression Profiles 1.0 0.944238 JEKO1 CCLE Cell Line Gene CNV Profiles -1.0 -1.44033 GEM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39144 fallopiantube_8d HPA Tissue Sample Gene Expression Profiles 1.0 2.08171 Perturb_5140_KO_Rn7sk_ERP002405 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.91974 GTEX-T2IS-0011-R3A-SM-32QPB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92794 RNF166 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.10858 Bladder Urothelial Carcinoma_BLCA_TCGA-SY-A9G5-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMC3_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUJ4-0226-SM-4BOP8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12188 GTEX-V1D1-0006-SM-3NMCE GTEx Tissue Sample Gene Expression Profiles 1.0 0.879212 occipital neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.846339 G402 DepMap CRISPR Gene Dependency 1.0 3.20265 Ventromedial hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3061 YMB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.4161 YD-49-HM53_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.264533 FLVCR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8669 MAX_02_192 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.6223 Sarcoma_SARC_TCGA-DX-A48O-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MOCS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66678 Nfatc1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.5755 Lingula (I), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48844 occipital pole, left, lateral aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.65372 POLR2A_bone marrow_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.23376 inferolateral temporal cortex (area TEv, area 20)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.39627 PMC11055867-41598_2024_60205_MOESM1_ESM.pdf-18-ESRRG_ESRRG Rummagene Transcription Factor Associations 2026 1.0 null LUDLU1 CCLE Cell Line Gene CNV Profiles -1.0 -1.34118 GTEX-U8T8-0008-SM-4DXSP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35905 GTEX-WFG8-0008-SM-4LVN6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21867 POLR3G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7035 NCI-H1838 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.916613 Lymphoma_burkitts(Raji) BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.8174 CEP152 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09932 COLO668 CCLE Cell Line Gene CNV Profiles 1.0 2.05773 CORL24 CCLE Cell Line Gene CNV Profiles 1.0 2.52723 ATAD3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47611 ETS1 ENCODE Transcription Factor Targets 1.0 null COX6B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.26079 GTEX-XGQ4-0126-SM-4AT4H GTEx Tissue Sample Gene Expression Profiles 1.0 0.840561 ZNF878 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11207 Bed nucleus of the accessory olfactory tract Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14569 anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.21398 Lhx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.3877 Perturb_14039_KO_Dnmt1/Dnmt3a/Dnmt3b/Creb1_SRP337936 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.81006 EFM-192B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.14993 KARPAS422 CCLE Cell Line Gene Expression Profiles 1.0 1.81129 ZNF195 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76544 HS 255.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.36385 Stat2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 87.6997 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.41692 GTEX-POMQ-0008-SM-48TE7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.059 CMK COSMIC Cell Line Gene Mutation Profiles 1.0 null POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRC-2_Deficiency_GDS5087_270_mouse_Heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null LONP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45774 GTEX-TMZS-0006-SM-3DB8G GTEx Tissue Sample Gene Expression Profiles 1.0 0.975117 GTEX-WZTO-0011-R10B-SM-4E3KB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.979897 Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6795-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T6MN-1226-SM-3NMA5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.893225 HAND2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.683 intermediate stratum of r6BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.88785 occipital pole, left, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.64914 CCNT2 ENCODE Transcription Factor Targets 1.0 null PYGM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20974 GTEX-O5YU-0008-SM-4E3I7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2242 Apolipoprotein A1 levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.730103 H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null MHH-ES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06013 VPS29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47563 TYK-NU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.9053 Subcortical volume (MOSTest) GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.33979 GTEX-SIU7-0006-SM-2XCE6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.61493 GTEX-XBED-0006-SM-47JXO GTEx Tissue Sample Gene Expression Profiles 1.0 1.00836 R3HCC1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49923 caudal subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.898976 H3K4me1_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null pancreas_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.27555 DHPS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57021 GSE133213_6_v_1_znrf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null COX19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.4699 Subcortical volume (min-P) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.752288 PGRMC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.44549 CTV-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null MYH10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69273 OCIMY5 DepMap CRISPR Gene Dependency 1.0 3.65447 PMC11024925-mmc3.xlsx-Gene_lists-MV411_FOS_ChIP_and_RNA_overlap_after_10_nM_Gilteritinib_FOS Rummagene Transcription Factor Associations 2026 1.0 null GSE172295_1_v_2_sh3gl1_mouse RummaGEO Gene Perturbation Signatures 1.0 null RASAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4037 GSE203267_0_v_1_alkbh5_human RummaGEO Gene Perturbation Signatures -1.0 null SALE CCLE Cell Line Gene Expression Profiles 1.0 2.34047 GSE62843,GSE64370_0_v_5_furan_mouse RummaGEO Drug Perturbation Signatures -1.0 null HDAC2 ENCODE Transcription Factor Targets 1.0 null AKAP12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82477 SDR39U1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52272 H3K4me1_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_6951_KO_Rbm20_SRP328560 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.39952 H3K27ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GATA1 ENCODE Transcription Factor Targets 1.0 null NCI-H1793 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.40329 FBXO44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30117 r4 part of lateral vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08612 GTEX-POYW-0526-SM-2XCEY GTEx Tissue Sample Gene Expression Profiles 1.0 0.859912 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5000-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF764 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26413 GTEX-RN64-0008-SM-48FEZ GTEx Tissue Sample Gene Expression Profiles -1.0 -4.16966 PMC12021535-CPH4-15-e70011-s001.xlsx-S21-KLF2_KLF2 Rummagene Transcription Factor Associations 2026 1.0 null primary auditory cortex (core)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.70848 MLH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72213 H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Atoh1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.0881 TBL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32571 NCIH69 CCLE Cell Line Gene Expression Profiles -1.0 -1.49281 Ebf2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.3534 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73A-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE193402_0_v_1_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null icSARS CoV_72Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.19955 MAX_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC4390530-NIHMS667786-supplement-1.xlsx-Sheet1-Supplementary_Table_2_Genes_closest_to_AR_induced_ASH2L_peaks_AR Rummagene Transcription Factor Associations 2026 1.0 null globus pallidus, external segment, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06609 TBC1D13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41185 ATOH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25892 PDCD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00549 SNU46 DepMap CRISPR Gene Dependency 1.0 4.92593 Lung adenocarcinoma_LUAD_TCGA-97-8552-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-UJMC-0005-SM-3GACU GTEx Tissue Sample Gene Expression Profiles 1.0 0.827371 MRPS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4796 GTEX-RU1J-0008-SM-46MV9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.72569 superficial stratum of SeDg Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22593 POLR2AphosphoS2_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-Unnamed_12_AR Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M9-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FAM219A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2322 Fetal_Intestine_Small Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.12834 POLR2AphosphoS5_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null OSR2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.3834 H3K9me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FOXP1 ChEA Transcription Factor Targets 1.0 null Bed nuclei of the stria terminalis, anterior division, anterolateral area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20748 ZNF707 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64174 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22279 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null Liver BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.21544 METTL24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52162 HCFC1 ENCODE Transcription Factor Targets 1.0 null Piriform-amygdalar area, polymorph layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33249 GTEX-Q2AI-0008-SM-48U2H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35936 GSE193402_0_v_3_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null PMC11392820-41556_2024_1475_MOESM3_ESM.xlsx-Supplementary_Table_9-Supplementary_Table_9_Expression_level_of_OTX2_targeted_genes_n_999_related_to_Figure_6_OTX2 Rummagene Transcription Factor Associations 2026 1.0 null isthmic part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25595 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4992-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE145311_1_v_3_glutathione_mouse RummaGEO Drug Perturbation Signatures 1.0 null POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of TPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.84258 GTEX-WEY5-0426-SM-3GIKT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.96917 cerebellar cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.832637 ASMTL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14155 r6 part of spinal vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1725 GSE215351,GSE215794_4_v_0_kdm8_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCI-H2347 COSMIC Cell Line Gene Mutation Profiles 1.0 null MDA-MB-361 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.255 POLR2AphosphoS5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBEW-0008-SM-4AT3Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48561 KIF1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91674 GSE154074_2_v_0_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null 496100514_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.57625 HCC1195 CCLE Cell Line Gene CNV Profiles 1.0 2.04484 Fetal Heart Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -0.83661 periventricular stratum of Hb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12444 H3K4me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null ALKAL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84992 GSE148321,GSE169423_2_v_1_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null post-anaphase microtubule array COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.931 GTEX-WH7G-0008-SM-4LVNM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32907 XKR8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01952 MTRF1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64377 intercalated nucleus of medulla Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.912121 GTEX-QDVN-0526-SM-48TZ4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.876844 NFYB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.9424 MON1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24841 Age-related hearing impairment GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.9 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5169-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.963958 Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUM-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LC1SQ DepMap CRISPR Gene Dependency 1.0 4.15872 Urinary system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 ZNF304 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74218 GSE189834,GSE189836_1_v_0_brd4_mouse RummaGEO Gene Perturbation Signatures 1.0 null Ventromedial hypothalamic nucleus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.60968 NEURL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87683 Lower respiratory tract disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.732 L1CAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12821 H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null OCILY10 CCLE Cell Line Gene Expression Profiles 1.0 1.57182 GTEX-QDVN-0008-SM-48U2D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44389 PPP2R1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04541 GSE244710_3_v_0_srsf1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XMD1-0826-SM-4AT52 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05879 FOSL2 ENCODE Transcription Factor Targets 1.0 null HCC827 DepMap CRISPR Gene Dependency 1.0 2.00478 CRTC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17029 ASL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38046 GTEX-R55C-0005-SM-3GAE9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.920149 SNU1066 DepMap CRISPR Gene Dependency 1.0 2.24854 PRRG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73578 EPC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96055 MSH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25366 HCC1171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11623 SOX9-24532713-HFSC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null N6AMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50084 HEG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90283 shell of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07236 ATAD3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35018 Lung squamous cell carcinoma_LUSC_TCGA-96-A4JL-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE228017_0_v_1_parthenolide_human RummaGEO Drug Perturbation Signatures 1.0 null PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Up_regulated_DEGs_of_KD_AR Rummagene Transcription Factor Associations 2026 1.0 null COG7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53438 H3K4me1_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CCNG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84334 Perturb_5135_KO_Ythdc1_SRP251747 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.43329 arcuate nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.95827 Skin Cutaneous Melanoma_SKCM_TCGA-GF-A769-01A-32R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BA-56-QV45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.270556 KCTD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10243 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5UM-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31728 POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BTRC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44794 SLR23 DepMap CRISPR Gene Dependency 1.0 2.00215 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A4BB-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RCOR1 ENCODE Transcription Factor Targets 1.0 null MAP3K20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34614 H3K4me1_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null HEATR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77979 SPDEF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70758 Hepatic Cirrhosis_Hepatic Tissue_GSE1843 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.94034 H3K36me3_Brain Germinal Matrix Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MDA-MB-231 COSMIC Cell Line Gene Mutation Profiles 1.0 null dorsolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.999251 pineal body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 3.04226 H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Ovary BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.8625 H3K9me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null periventricular stratum of m2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46624 NDUFA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5554 GTEX-O5YT-0926-SM-48TDG GTEx Tissue Sample Gene Expression Profiles 1.0 1.06333 GTEX-WFON-0005-SM-3NMC9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.41931 posteroventral (inferior) parietal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.42051 Field CA3, stratum oriens Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26459 SMRT-27268052-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null fallopiantube_8b HPA Tissue Sample Gene Expression Profiles 1.0 1.18808 EPLC272H DepMap CRISPR Gene Dependency 1.0 3.55582 BCL7B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58 H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RASGEF1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98537 NPRL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1109 H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF197 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22453 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4335-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OVCAR-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.59854 GTEX-X4LF-0006-SM-3NMCO GTEx Tissue Sample Gene Expression Profiles 1.0 1.40987 GTEX-RWS6-0008-SM-47JYV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.69939 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WYBS-1126-SM-3NMAM GTEx Tissue Sample Gene Expression Profiles 1.0 1.24345 SUM225CWN Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.56947 C2CD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54406 UBTF ENCODE Transcription Factor Targets 1.0 null Bhlha15 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.0174 intermediate stratum of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.84258 parasolitary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.06027 NAT8L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17838 PDP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00675 NCI-H2106 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.0059 ZNF544 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.97377 MAFG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58835 Leprosy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.046 HOXB5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90726 GTEX-S4P3-0006-SM-3K2AW GTEx Tissue Sample Gene Expression Profiles 1.0 1.07749 PHYHIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67354 H3K4me1_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-91-6847-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dexamethasone_rattus norvegicus_gpl1355_gse29912 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BL5105 (BRF1) NURSA Protein Complexes 1.0 null GSE154074_2_v_4_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null HS 852.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.69341 GSE185163_3_v_1_clic4_mouse RummaGEO Gene Perturbation Signatures -1.0 null periventricular stratum of the PBC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.45927 E2F6 ENCODE Transcription Factor Targets 1.0 null periventricular stratum of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40318 SELENOV CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8657 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JF-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RNOR-0008-SM-48FEY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10616 MEPCE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44463 EKVX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15071 TRAPPC6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37116 NFKB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63827 GTEX-XOTO-2826-SM-4B65I GTEx Tissue Sample Gene Expression Profiles 1.0 0.860642 ATP5F1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88918 BRIX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06304 SIK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67083 GTEX-WEY5-0006-SM-3GIKG GTEx Tissue Sample Gene Expression Profiles 1.0 0.886512 VCPKMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.84921 VMRC-LCD Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.894387 Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A47O-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_14004_OE_Kcnj2_SRP309478 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.2414 Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7H7-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC630 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13321 Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H3-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1915 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.20746 MTMR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89212 H3K4me1_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TRIM32 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.13128 ASH-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null diagonal part of septum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1725 PPP4R3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26442 IPPK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22585 intermediate stratum of TG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.68279 Perturb_6982_KO_Nlrp3_SRP173143 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.40101 Anterior cingulate area, ventral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0319 horizontal nucleus of the diagonal band, transitional part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22593 GTEX-REY6-0526-SM-2TF5M GTEx Tissue Sample Gene Expression Profiles 1.0 0.84646 NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.48061 POLR2AphosphoS5_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SOX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98247 H3K36me3_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null amygdaloid complex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.933088 CAMA1 CCLE Cell Line Gene CNV Profiles -1.0 -1.82212 H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R3RS-0008-SM-48FF1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46151 Lung squamous cell carcinoma_LUSC_TCGA-43-5670-11A-01R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CORL47 CCLE Cell Line Gene CNV Profiles -1.0 -1.49978 GTEX-QDVN-0726-SM-4B64L GTEx Tissue Sample Gene Expression Profiles 1.0 0.937403 GTEX-RUSQ-0626-SM-2TF5V GTEx Tissue Sample Gene Expression Profiles 1.0 1.80661 PNPLA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14675 GTEX-S341-0008-SM-4AD6D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.95387 GFOD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21385 PL45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.46979 GTEX-XLM4-0005-SM-4AT4P GTEx Tissue Sample Gene Expression Profiles 1.0 0.849291 888 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.891268 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80Q-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r9 part of nucleus of Roller Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14727 Fetal_Intestine_Large Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.4522 GTEX-PVOW-1026-SM-2XCF9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.969616 GTEX-RUSQ-1026-SM-2TF6V GTEx Tissue Sample Gene Expression Profiles 1.0 1.14297 496100411_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.67341 NIPSNAP3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85007 P53-21459846-SAOS-2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null NAPB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05825 Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAUZ-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null organelle LOCATE Curated Protein Localization Annotations 1.0 null POLR2AphosphoS2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZC3H4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50421 GTEX-XUW1-0008-SM-4BOQH GTEx Tissue Sample Gene Expression Profiles -1.0 -2.16087 GTEX-WH7G-0726-SM-3NMBM GTEx Tissue Sample Gene Expression Profiles 1.0 1.64429 IFI27L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96322 primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.67227 SIN3A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null C10orf88 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23445 GlobusPallidus BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.963842 GTEX-PWO3-0011-R8A-SM-2I5GD GTEx Tissue Sample Gene Expression Profiles 1.0 0.851333 Trachea-ciliated cell Tabula Sapiens Gene-Cell Associations 1.0 10.3118 H3K27ac_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10205 TIMMDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81629 POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.962843 H3K4me3_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Sarcoma_SARC_TCGA-WK-A8XQ-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DMRTC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33114 GTEX-RVPV-0008-SM-47JYW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00842 496100278_FWM_no dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.55669 rostral paraventricular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.84258 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RW-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null INO80C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.44033 MDA-MB-175-VII Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.18122 Perturb_15117_KD_Rtn4_SRP278924 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.63894 GTEX-QEG5-0006-SM-2I5FZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.30798 HOXB7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46379 intermediate stratum of r5BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1812 GTEX-WRHU-0226-SM-3MJFV GTEx Tissue Sample Gene Expression Profiles 1.0 1.78841 HNFA-21074721-CACO-2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-NL3H-0011-R4a-SM-2I3GK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.855423 Brain Lower Grade Glioma_LGG_TCGA-S9-A7R8-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QXCU-0326-SM-2TC63 GTEx Tissue Sample Gene Expression Profiles 1.0 0.983794 THP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22279 sirolimus_homo sapiens_gpl2895_gse16944 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null DEDD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67255 CAPAN2 CCLE Cell Line Gene CNV Profiles -1.0 -1.35717 GTEX-SIU8-0008-SM-4BRUC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34917 CTCF_CH12.LX_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNRPC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23243 RUSC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30426 GTEX-R55G-0226-SM-48FEI GTEx Tissue Sample Gene Expression Profiles 1.0 0.876877 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4969-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HEL COSMIC Cell Line Gene Mutation Profiles 1.0 null FGFR3 Pathway Commons Protein-Protein Interactions 1.0 null ZNF316 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23651 CPNE7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23432 GTEX-OXRO-0011-R2A-SM-3NB1W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16199 Brain Lower Grade Glioma_LGG_TCGA-DU-A5TP-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MICALL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59955 HOXB7_01_170 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 3.79481 GTEX-XUZC-1426-SM-4BRV3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.835368 Lung squamous cell carcinoma_LUSC_TCGA-43-7658-11A-01R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H2052 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.889093 ventrolateral prefrontal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.892282 SG in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.39174 STC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46208 BHLHE40 ENCODE Transcription Factor Targets 1.0 null Orbital area, ventrolateral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18731 TAPBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29185 NFE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27157 MOLT-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-S95S-0005-SM-2XCEC GTEx Tissue Sample Gene Expression Profiles 1.0 1.32119 GTEX-WFON-0126-SM-4LVM9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2343 principal pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06448 Necrosis CTD Gene-Disease Associations 1.0 1.17202 HEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.68323 ZNF239 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73922 GTEX-PWOO-0008-SM-48TDU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35758 KPNYN CCLE Cell Line Gene CNV Profiles -1.0 -2.06142 Urinary bladder TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Sarcoma_SARC_TCGA-DX-A6BB-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA Rummagene Transcription Factor Associations 2026 1.0 null VAMP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38192 BLACAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71428 GTEX-R45C-0008-SM-48FF2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03903 NCIH211 CCLE Cell Line Gene Expression Profiles 1.0 1.73877 H3K4me3_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GRHL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63941 Paragigantocellular reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.22033 POLR2AphosphoS5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A6C5-11A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_1119_OE_RUNX1_ERP106519 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.65463 UBTF_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PVOW-0011-R3A-SM-32PKX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.933206 MXI1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gata3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.0763 GMFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33041 CYP27C1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77375 NFATC2IP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62147 ACBD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71977 TULP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17944 GTEX-XPVG-0008-SM-4GICH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12512 DENND5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0771 FADU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.26111 HERC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19643 NR3C2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.5293 pontine raphe nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.859565 GTEX-XV7Q-0008-SM-4BRWL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10273 MAF-26560356-CHIP-SEQ-TH1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null periventricular stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05926 H3K4me1_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.99648 r9 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02707 primary motor cortex (area M1, area 4)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.84995 KRIT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06462 SA1-27219007-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BECKER DepMap CRISPR Gene Dependency 1.0 2.27503 III, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.889728 OGFOD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.14849 Iron status biomarkers (transferrin saturation) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.609691 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6934-11A-01R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZSCAN20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65085 H3K36me3_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.95759 ECGI10 CCLE Cell Line Gene Expression Profiles 1.0 2.68447 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4878-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RVPU-0011-R10A-SM-2XCAH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.995534 CBX8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33491 MFE296 DepMap CRISPR Gene Dependency 1.0 2.38711 TP53 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.9691 PrefrontalCortex BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.989302 CAOV3 CCLE Cell Line Gene CNV Profiles 1.0 1.43945 superficial stratum of r4Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08612 GCH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48855 CLDN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50966 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D6-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBP_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FBXL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.0153 Perturb_16911_KO_Ezh2_SRP314053 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.75552 GTEX-UJMC-1326-SM-4IHLS GTEx Tissue Sample Gene Expression Profiles 1.0 1.08067 H3K36me3_erythroblast_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null COMMD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37789 PORCN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54394 H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE249098_1_v_2_mthfd1l_human RummaGEO Gene Perturbation Signatures 1.0 null TP73 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.5938 Artery - Aorta GTEx Tissue Gene Expression Profiles 2023 1.0 2.72922 GSE185163_5_v_2_clic4_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WHPG-1426-SM-3NMBB GTEx Tissue Sample Gene Expression Profiles 1.0 1.1146 mantle zone of r10Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1812 GTEX-X3Y1-0006-SM-3P5ZG GTEx Tissue Sample Gene Expression Profiles 1.0 1.25792 Lobule II Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54849 PCYT1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17615 RELCH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2816 NCIH2029 CCLE Cell Line Gene CNV Profiles 1.0 2.35753 Spinal nucleus of the trigeminal, oral part, middle dorsomedial part, ventral zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.99307 SLR25 CCLE Cell Line Gene Expression Profiles -1.0 -1.7186 GTEX-PX3G-0526-SM-2I3EM GTEx Tissue Sample Gene Expression Profiles 1.0 1.4803 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4697-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null rhombomere 9 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.1476 pontomedullary hindbrain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.33952 HECTD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84278 COLO 201 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.833626 H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCIH2029 CCLE Cell Line Gene Expression Profiles 1.0 1.69091 ZMIZ1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nobox JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 14.9474 GTEX-TSE9-0011-R6A-SM-3DB7L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.875076 GTEX-OHPK-0008-SM-4E3JL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.988854 GTEX-X585-0011-R10A-SM-46MUY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00208 H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M4-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMYD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30658 SUMO3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02451 GTEX-R55E-0008-SM-48FCG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0334 KMS20 CCLE Cell Line Gene CNV Profiles -1.0 -1.81165 MAZ_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE151829,GSE151831_7_v_8_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null EP300 ENCODE Transcription Factor Targets 1.0 null GTEX-WXYG-0005-SM-3NB3M GTEx Tissue Sample Gene Expression Profiles 1.0 1.42403 GSE171837_3_v_2_bortezomib_mouse RummaGEO Drug Perturbation Signatures 1.0 null NR3C1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.3488 WBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35975 CAB39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64735 ZBTB18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07276 dorsolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.41326 HNF4A_KD_GDS4798_550_human_HepG2 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Cortical surface area (min-P) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.769897 JUND ENCODE Transcription Factor Targets 1.0 null superficial stratum of r6Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.80713 OVTOKO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null ASPSCR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92256 L363 CCLE Cell Line Gene Expression Profiles 1.0 1.48495 GTEX-S7SE-0011-R10A-SM-2XCDF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13347 PMC4521181-oncsis201520x8.pdf-14-NFIA_NFIA Rummagene Transcription Factor Associations 2026 1.0 null primary auditory cortex (core)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.211 PHETA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89823 GTEX-SN8G-1526-SM-4DM79 GTEx Tissue Sample Gene Expression Profiles 1.0 0.835894 GTEX-T5JW-0008-SM-4DM5X GTEx Tissue Sample Gene Expression Profiles -1.0 -2.87625 H3K27ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SSTR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54769 HEPG2 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.847778 Diagonal band nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09338 H3K27ac_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE95077_5_v_0_amiloride_human RummaGEO Drug Perturbation Signatures 1.0 null TP63 ChEA Transcription Factor Targets 1.0 null LRRC47 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48791 P3HR1 CCLE Cell Line Gene Expression Profiles 1.0 1.41203 GTEX-XGQ4-0005-SM-4AT5U GTEx Tissue Sample Gene Expression Profiles 1.0 1.27955 EPN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44677 CCDC93 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.72687 GTEX-XUZC-0008-SM-4BOQG GTEx Tissue Sample Gene Expression Profiles -1.0 -2.04332 TBP_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-W5WG-0006-SM-3GIJT GTEx Tissue Sample Gene Expression Profiles 1.0 1.22462 SEMA4G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.67853 NTMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97162 GID8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7728 POLR2AphosphoS5_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC ChEA Transcription Factor Targets 1.0 null GTEX-WZTO-0011-R3B-SM-3NMC6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09611 inferior temporal gyrus, right, bank of the its Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.941221 RADX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30539 H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SUCS-0008-SM-4DM53 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56018 NPTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43121 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.41245 H3K27me3_erythroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETV1-20927104-GIST48-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE199034_1_v_0_pirfenidone_mouse RummaGEO Drug Perturbation Signatures -1.0 null OUMS-23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.54463 MDAMB468 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -2.81837 GTEX-O5YV-0008-SM-4E3HP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0862 Lung squamous cell carcinoma_LUSC_TCGA-56-7579-11A-01R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null parietal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.89796 GTEX-S341-0326-SM-2XCAU GTEx Tissue Sample Gene Expression Profiles 1.0 3.04045 Kidney renal papillary cell carcinoma_KIRP_TCGA-WN-A9G9-01A-12R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XLM4-0011-R6A-SM-4AT4B GTEx Tissue Sample Gene Expression Profiles -1.0 -0.848637 KAT2A ENCODE Transcription Factor Targets 1.0 null MFSD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49941 SK-MEL-28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.55399 GTEX-U4B1-0008-SM-4DXUW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.94499 GSE185519_3_v_7_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WOFL-0726-SM-3MJG4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00972 Atf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.7615 GTEX-U3ZM-0008-SM-4DXTQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49527 MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03612 SETDB1 ENCODE Transcription Factor Targets 1.0 null MMACHC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.338 GTEX-R55F-0005-SM-2TF4W GTEx Tissue Sample Gene Expression Profiles 1.0 1.09054 APEH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26914 DB-54-GQ68_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.444463 r9 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5178 Medial septal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07913 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4XL-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Exocrine gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 H3K4me1_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null RRP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21255 Perturb_12772_KO_Bin1_SRP201679 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.28469 MGE-Lateral region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.96298 POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100532_FWM_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.06174 NDUFAF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52454 mantle zone of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1161 KS-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null VP229 DepMap CRISPR Gene Dependency 1.0 2.4854 interstitial nucleus of Cajal, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.33498 GTEX-XBEW-0126-SM-4AT66 GTEx Tissue Sample Gene Expression Profiles 1.0 0.958625 H3K27ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null periventricular stratum of m2AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.90104 GTEX-R55C-1126-SM-48FCJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.872124 GTEX-V955-0005-SM-3P5ZC GTEx Tissue Sample Gene Expression Profiles 1.0 1.53699 dorsal terminal nucleus of the accessory optic tract Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12411 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4822-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null EB2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.845087 OCIP5X DepMap CRISPR Gene Dependency 1.0 2.25821 HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.32077 INHBE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72965 posteroventral (inferior) parietal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.03877 PCNX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62866 r6 part of ventral gigangocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04587 GSE225735_1_v_4_aldosterone_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-QCQG-0326-SM-2I3ES GTEx Tissue Sample Gene Expression Profiles 1.0 1.09908 ZBTB49 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58739 DLD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63467 GTEX-QEG5-1126-SM-33HC2 GTEx Tissue Sample Gene Expression Profiles 1.0 2.02816 interpositus (intermediate) nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.17357 r6 basal plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38605 Acute Myeloid Leukemia_LAML_TCGA-AB-2811-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF671 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42833 MDAMB453 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.28922 Lung adenocarcinoma_LUAD_TCGA-44-6148-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hippocampus (hippocampal formation)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.0444 Ovarian Diseases CTD Gene-Disease Associations 1.0 1.01852 rhombomere 6 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.25961 CHST4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46199 Lung squamous cell carcinoma_LUSC_TCGA-22-5489-11A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAPKAPK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.61766 GNPDA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47534 VZ in rostral cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.846786 r9 part of the vestibular column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28474 posteromedial visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31728 Perturb_17593_KO_Pbrm1_SRP250724 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.72089 RCC4 CCLE Cell Line Gene CNV Profiles 1.0 1.98082 GSE171175,GSE171181_1_v_2_e7107_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-1914 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 MFM-223 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.58004 H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null paracentral lobule, anterior part, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.928687 hsa-miR-1273g TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 RARA::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.5217 H3K4me1_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PPARG JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-WFJO-0008-SM-4LVN7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4469 OCI-M2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.921815 KLHL34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.94119 COL1A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97412 DSC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17428 GTEX-WEY5-0226-SM-3GIKN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.997236 hsa-miR-4747-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 UF-27-HS98_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.378562 RIC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18347 pancreas HPA Tissue Gene Expression Profiles -1.0 -1.27505 interstitial nucleus of Cajal, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.11471 lateral medullary reticular group, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.829047 mantle zone of DgSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1725 H3K36me3_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4XY-0011-R8A-SM-46MVC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.945532 GSE199899_4_v_0_diethylnitrosamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null Pax7 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.6957 RBMY1A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1845 TYKNU CCLE Cell Line Gene CNV Profiles 1.0 1.50018 Perturb_6365_KO_Hnrnpu_SRP250313 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 8.93392 RPS24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02775 TNNT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6236 nucleus sagulum, deep part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55874 OVCA 420 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.869827 JRKL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.3922 GTPBP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21053 dorsolateral preisthmic part of periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.11441 NELFE_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cingulate gyrus, parietal part, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.70708 H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE51684,GSE51741_2_v_4_c9orf72_human RummaGEO Gene Perturbation Signatures -1.0 null RTN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61607 Lung adenocarcinoma_LUAD_TCGA-MP-A4TJ-01A-51R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WRHK-0005-SM-3MJF5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.45147 SMAD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.62336 GTEX-T6MN-2626-SM-32PMQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.947887 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4349-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral hypothalamic area, anterior part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10127 ONECUT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.6369 PMC12821819-40478_2025_2173_MOESM9_ESM.xlsx-Supplementary_Table_3a-Supplementary_Table_3A_List_of_Top_1000_Genes_with_the_Highest_Stochasticity_by_JSD_in_the_ATRT-MYC_Subtype_MYC Rummagene Transcription Factor Associations 2026 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5UL-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210580_4_v_7_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QMR6-0011-R10A-SM-32PKO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04113 NUCB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90326 H3K9ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE101767_1_v_0_wdr11_mouse RummaGEO Gene Perturbation Signatures 1.0 null OCLN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68416 TP63-23658742-EP156T-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTPBP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.448 TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null ZNF296 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59604 DDX39B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2289 PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null Skin squamous cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.171 HES7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.3079 PMC8494348-pone.0257161.s002.xlsx-only_OXT_NOT_ext-OXT_ext-Gene_Name_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null outer portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.910582 EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null G84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.839751 TOV112D DepMap CRISPR Gene Dependency 1.0 2.60842 Outer dynein arm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.771 GTEX-X4XX-0926-SM-46MV7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04372 GSE168401_2_v_3_harmine_human RummaGEO Drug Perturbation Signatures 1.0 null H3C14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50218 orbital frontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.99964 GTEX-RN64-1826-SM-48FDV GTEx Tissue Sample Gene Expression Profiles 1.0 0.978039 NR4A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07529 LXFL529 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22279 ZNF551 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73601 NELFE ENCODE Transcription Factor Targets 1.0 null GLYATL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60813 Hmx2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 31.8285 HCC1319 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.50797 Orbital area, ventrolateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61409 SARS-BatSRBD_Day7_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.79114 GTEX-OXRL-0008-SM-3NB29 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.14903 mantle zone of r9Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28474 Inflammation CTD Gene-Disease Associations 1.0 1.06152 GTEX-X8HC-0726-SM-46MWG GTEx Tissue Sample Gene Expression Profiles 1.0 1.19472 inner CP in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.52001 Heart disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.061 Perturb_5980_KD_XRN2_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.36279 Periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.8963 SUPT11 CCLE Cell Line Gene CNV Profiles -1.0 -1.72881 Bed nuclei of the stria terminalis, anterior division, juxtacapsular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23102 ZNF653 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31701 anterior (rostral) cingulate (medial prefrontal) cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.2779 JMJD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27113 ACSM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75336 Lung adenocarcinoma_LUAD_TCGA-91-6835-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ptf1a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 61.7502 CRYBG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00492 GTEX-XPT6-0008-SM-4B64Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31761 TK-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.28485 TMEM37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34728 QDPR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49538 CEBPD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.9484 inferior frontal gyrus, orbital part, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.9555 Lung squamous cell carcinoma_LUSC_TCGA-85-A4JC-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Mafg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.7755 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4845-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BFAR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36672 SUM52PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.751308 SK-MEL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.42408 GSE164505,GSE164506_3_v_2_indisulam_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_CH12.LX_mm9_5 ENCODE Histone Modification Site Profiles 1.0 null GSE164463_2_v_1_pax6_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF708 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.3051 POLR2A_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUJ4-0005-SM-4BOQ6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.55816 cuneus, right, peristriate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13812 TMED10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77397 IZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14857 RPMI 8226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.49105 PMC7861567__F5 PFOCR Pathway Figure Associations 2024 1.0 null BICR56 CCLE Cell Line Gene Expression Profiles 1.0 1.53862 SP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.36495 VDAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07988 r5 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62603 Midbrain raphe nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26459 H3K27ac_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T6MO-0008-SM-4DM6T GTEx Tissue Sample Gene Expression Profiles -1.0 -2.23821 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3426-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SGPP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21202 PRDM8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32539 GATA6-21074721-CACO-2-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CEBPB-20513432-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null WHSC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZI-0008-SM-2XCFD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78104 Magnocellular reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32832 POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9498168__F6a PFOCR Pathway Figure Associations 2024 1.0 null ING3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12815 KAT2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CD8_Naive_Primary_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.23318 H3K4me1_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null INA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.81016 Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A0C8-01A-11R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 16912175-SuppTable3b GeneSigDB Published Gene Signatures 1.0 null NOTCH4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99792 primary auditory cortex (core)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.58112 hippocampus (hippocampal formation)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.992038 AGFG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5213 TTI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3255 RERF-GC-1B COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles 1.0 0.843298 Perturb_12649_KD_DIRC3_SRP191422 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 mediodorsal nucleus of thalamus_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.68352 OVMIU DepMap CRISPR Gene Dependency 1.0 4.9621 NCIH1648 CCLE Cell Line Gene Expression Profiles 1.0 2.20453 IP6K2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76955 outer SZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.903814 A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_1day-MOI-10^4_None_GSE44445 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.14167 A172 DepMap CRISPR Gene Dependency 1.0 4.3294 SOX9-24532713-HFSC-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QEL4-0726-SM-3GIJ5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.905168 21205295-TableS1 GeneSigDB Published Gene Signatures 1.0 null GTEX-SNMC-0006-SM-2XCFE GTEx Tissue Sample Gene Expression Profiles 1.0 1.51701 GTEX-X4EP-0526-SM-3P5YW GTEx Tissue Sample Gene Expression Profiles 1.0 1.11142 UBLC1 DepMap CRISPR Gene Dependency 1.0 2.21705 GTEX-OOBK-0526-SM-2HMJJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.90597 KLF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93218 superficial stratum of p2ZL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2746 Superior colliculus, motor related, intermediate gray layer, sublayer a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.5963 dorsolateral IC periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.14655 TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Primary hematopoietic stem cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 0.849834 MYC-20876797-MEDULLOBLASTOMA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null isthmic liminal part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47141 H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Salivary gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Pheochromocytoma and Paraganglioma_PCPG_TCGA-XG-A823-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-Q2AI-1326-SM-2S1PL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.860101 GTEX-T6MN-0826-SM-32PM4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.927655 lambdoid septal zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1725 GTEX-QVUS-0011-R1A-SM-3GAD2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21035 upper (rostral) rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.904519 HABP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44223 CEP131 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20703 ZNF384 ENCODE Transcription Factor Targets 1.0 null RNF185 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85169 ZNF214 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.0389 intracellular part LOCATE Curated Protein Localization Annotations 1.0 null GTEX-S4UY-0008-SM-3NM8H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.83154 ADM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17025 MAPK8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.19544 ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null TENM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.724 GTEX-XQ3S-0008-SM-4GIDZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11331 r7 part of spinal trigeminal nucleus, interpolar part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.50355 TMEM218 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15671 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of m2AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66887 CCDC85C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2567 WNK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26365 T98G Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.44657 GTEX-RVPU-0011-R3A-SM-2XCAE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04717 UACC257 DepMap CRISPR Gene Dependency 1.0 2.47899 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GT-01A-12R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DND41 CCLE Cell Line Gene Expression Profiles 1.0 1.44258 Anteroventral periventricular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05259 A-Vietnam-1203-2004(H5N1)_7Hour_21865398_GSE28166 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.31566 GTEX-PWCY-0008-SM-48TE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43305 SDHC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91076 HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.16284 OGDHL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80116 GTEX-TSE9-0326-SM-3DB82 GTEx Tissue Sample Gene Expression Profiles 1.0 1.23194 placenta_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.77839 lung HPA Tissue Gene Expression Profiles 1.0 1.24912 GTEX-OXRL-0005-SM-3LK6A GTEx Tissue Sample Gene Expression Profiles 1.0 1.09552 POLR2A_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WHPG-0006-SM-3NMBV GTEx Tissue Sample Gene Expression Profiles 1.0 0.963821 JARID1A-20064375-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null ATOH7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56848 superficial stratum of r5Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14727 GSE206226_2_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-SUPPLEMENTARY_TABLE_12_Bulk_RNA-seq_results_of_invasive_fractions_from_GBM43_CTH_knockdwn_vs_GBM43_control_cells_invading_3D_hydrogels_AR Rummagene Transcription Factor Associations 2026 1.0 null posterior (caudal) superior temporal cortex (area 22c)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.98327 VZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.21324 H3K4me3_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BICR22 CCLE Cell Line Gene Expression Profiles 1.0 2.21298 SNIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47158 RBM47 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.21769 P2RX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66904 r9 basal plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26459 superficial stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17007 H3K4me3_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P4QS-0926-SM-48TBS GTEx Tissue Sample Gene Expression Profiles 1.0 0.889798 GSE188869,GSE188871_1_v_3_kat7_mouse RummaGEO Gene Perturbation Signatures 1.0 null NR3C2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6586 HCN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92884 H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null RRP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32243 GTEX-S341-1326-SM-4AD72 GTEx Tissue Sample Gene Expression Profiles 1.0 2.41564 BFTC-905 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-SE5C-0926-SM-4BRUF GTEx Tissue Sample Gene Expression Profiles 1.0 1.11043 MYOCD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3963 H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.946 BT-483 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.29574 medial superior olive Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.991457 NCI-H1648 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.54272 PMC12323057-13148_2025_1945_MOESM2_ESM.xlsx-17-Supplementary_Table_17_Overview_of_number_of_targets_genes_shared_with_THRB_THRB Rummagene Transcription Factor Associations 2026 1.0 null ACADM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09221 PRDX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.4375 r5 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1897 superficial stratum of TG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55435 SARS-dORF6_60Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.47461 GTEX-X585-0011-R3B-SM-46MVG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00905 RS4-11 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE132948,GSE132949_4_v_1_msi2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Sarcoma_SARC_TCGA-DX-A6YZ-01A-12R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FR-A726-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A6HP-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null SNU-216 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.08011 RBPJ-21746931-IB4-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SYT12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.95235 Lung Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.87809 REH COSMIC Cell Line Gene Mutation Profiles 1.0 null KASUMI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.31595 NHLH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44295 ARH-77 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE202434,GSE202438_4_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null ZMIZ1 ENCODE Transcription Factor Targets 1.0 null GMEB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12045 SW 1417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08443 H3K27ac_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null PPL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99371 LRP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.90208 paraventricular nuclei, left of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.07408 HCC1599 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.17208 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4337-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K-562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.904465 H3C4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23516 lateral orbital frontal cortex (area 12/47) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13586 H3K4me1_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RBM27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30643 GTEX-NL4W-0008-SM-4E3I2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26673 KMS-28PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07886 CASZ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70972 lateral subdivision of BNST Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.51808 GTEX-PW2O-0008-SM-48TEB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.988164 UBE2D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17068 BCPAP CCLE Cell Line Gene CNV Profiles 1.0 1.39577 NCIH28 DepMap CRISPR Gene Dependency 1.0 2.13336 GTEX-P78B-0926-SM-2I5FA GTEx Tissue Sample Gene Expression Profiles 1.0 1.54792 FADU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03335 RC-52-AC88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.20299 OVCA420 DepMap CRISPR Gene Dependency 1.0 3.18771 H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9RC-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3C8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47125 USP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26617 DMS153 CCLE Cell Line Gene CNV Profiles 1.0 1.63147 TNIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58718 U2AF1L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.0357 TP53INP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50587 GTEX-OOBJ-0526-SM-48TDK GTEx Tissue Sample Gene Expression Profiles 1.0 2.25147 lateral terminal nucleus of the accessory optic tract, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26995 SK-MM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.03781 GSE207301,GSE207303_1_v_2_tp53bp2_human RummaGEO Gene Perturbation Signatures 1.0 null GSE158431_2_v_6_pioglitazone_mouse RummaGEO Drug Perturbation Signatures 1.0 null SFR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78699 Uterus-ciliated epithelial cell Tabula Sapiens Gene-Cell Associations 1.0 0.628241 FOSL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Heschl's gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.939347 GSE248634_1_v_0_gnas_human RummaGEO Gene Perturbation Signatures 1.0 null ZCCHC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15294 H4C14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28202 BHLHE41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.14261 POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRP-0526-SM-2I3EW GTEx Tissue Sample Gene Expression Profiles 1.0 1.63837 GTEX-UTHO-2726-SM-4JBH9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02225 PMC10703699-41588_2023_1554_MOESM3_ESM.xlsx-T6C_mageckTFkoscreen_wo_BATF3-gene_BATF3 Rummagene Transcription Factor Associations 2026 1.0 null TSC22D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54937 GTEX-S7PM-0011-R6A-SM-3NM8F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.851201 G122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03248 LXF289 CCLE Cell Line Gene Expression Profiles 1.0 1.40746 mantle zone of r6BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.04993 GTEX-PLZ6-0008-SM-48TD5 GTEx Tissue Sample Gene Expression Profiles -1.0 -3.32966 CORL105 CCLE Cell Line Gene CNV Profiles -1.0 -1.55734 H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ventrolateral prefrontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.858989 RGL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74888 H3K4me1_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QV31-0008-SM-447AT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90044 GAPDHS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46245 GTEX-QDVJ-0008-SM-48U2E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33085 Ventromedial hypothalamic nucleus, ventrolateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2746 GTEX-X5EB-0426-SM-46MVY GTEx Tissue Sample Gene Expression Profiles 1.0 2.89036 496100577_FWM_probable Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.23344 HEY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.877572 periventricular stratum of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26459 KMS-28PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.2349 ventrolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.85426 GTEX-WFG7-0005-SM-3GIKM GTEx Tissue Sample Gene Expression Profiles 1.0 1.04678 VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.16232 PTPN12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23851 H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RM2N-0008-SM-48FF3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35869 YY1AP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11286 GSE210476_11_v_10_rutaecarpine_human RummaGEO Drug Perturbation Signatures 1.0 null CHAGOK1 CCLE Cell Line Gene CNV Profiles 1.0 1.87468 gigantocellular reticular nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06157 GSE233647_4_v_0_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null TDRD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.55834 ST8SIA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43885 HEY DepMap CRISPR Gene Dependency 1.0 2.34786 TSPAN31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72143 POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ2-0008-SM-4DM5L GTEx Tissue Sample Gene Expression Profiles -1.0 -2.66963 8MGBA CCLE Cell Line Gene CNV Profiles 1.0 1.6491 GTEX-U3ZN-0008-SM-4DXTL GTEx Tissue Sample Gene Expression Profiles -1.0 -2.29738 ZER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41512 GTEX-SUCS-0626-SM-32PM5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.43686 CPNE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.50773 KYSE30 CCLE Cell Line Gene Expression Profiles 1.0 1.59193 Uterine Carcinosarcoma_UCS_TCGA-N6-A4VD-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VMCUB1 CCLE Cell Line Gene Expression Profiles 1.0 1.39804 GTEX-PLZ5-0006-SM-2S1NZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.32208 SCC90 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K9me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AH-0008-SM-48U2J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01186 inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.955517 GTEX-Q2AG-1026-SM-33HBW GTEx Tissue Sample Gene Expression Profiles 1.0 1.11029 Lung squamous cell carcinoma_LUSC_TCGA-43-A56U-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WYVS-0526-SM-3NM9W GTEx Tissue Sample Gene Expression Profiles 1.0 2.28333 GTEX-WFG7-0008-SM-4LMKB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.81355 DAGLB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70395 Jun JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.7047 GSE148321,GSE169423_0_v_1_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WVLH-0011-R2A-SM-3MJFJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.959535 periaqueductal gray substance, ventral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.970648 lung GTEx Tissue Gene Expression Profiles 1.0 1.13251 DF-00-BU08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.439974 COLO 829 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.9812 GSE246195,GSE246305_1_v_0_sin3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OXRO-0011-R10A-SM-2I5EH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63774 D542MG DepMap CRISPR Gene Dependency 1.0 3.35339 Anterior olfactory nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07018 WDR89 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19429 STAT5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.28107 Paragigantocellular reticular nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62603 GTEX-T2YK-0008-SM-4DM6M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.76085 POU3F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98808 CTCF_MEL cell line_mm9_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null UMC-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.895261 KNDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67776 lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.845759 IRF9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28295 POLR2A_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TSE9-2226-SM-4DXUR GTEx Tissue Sample Gene Expression Profiles 1.0 1.01255 GTEX-T6MN-0008-SM-4DM7H GTEx Tissue Sample Gene Expression Profiles -1.0 -2.65734 ZNF736 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60448 GTEX-N7MS-0011-R10A-SM-2HMJK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12562 GTEX-PLZ4-0926-SM-2S1OI GTEx Tissue Sample Gene Expression Profiles 1.0 0.971541 GTEX-Q2AG-1126-SM-48U1P GTEx Tissue Sample Gene Expression Profiles 1.0 0.824019 IL27RA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49098 H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12130184-12276_2025_1441_MOESM5_ESM.pdf-7-ZNF135_ZNF135 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WCDI-0008-SM-47JYE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35559 CCDC74B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69408 SK-MEL-31 COSMIC Cell Line Gene Mutation Profiles 1.0 null r8 part of inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01454 GSE131161_5_v_4_rarres1_mouse RummaGEO Gene Perturbation Signatures -1.0 null ATP5MC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58589 TP53 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37498 POLR2A_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cockayne syndrome A DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.162 PMC7895828-41419_2021_3488_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_3_List_of_deregulated_genes_in_c-MYC_altered_human_HCC_from_TCGA_LIHC_dataset_MYC Rummagene Transcription Factor Associations 2026 1.0 null KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08443 KYSE-70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.44839 SPG11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73123 FUCA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06291 NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.933225 Sarcoma_SARC_TCGA-DX-A3UE-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AOB, internal plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06661 SYCE1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16282 Pancreatic adenocarcinoma_PAAD_TCGA-US-A776-01A-13R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100587_FWM_possible Alzheimer's disease_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.18603 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XBEC-1526-SM-4AT68 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04202 CDC16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71863 Perturb_17594_KO_Pbrm1_SRP250724 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.67353 PTPRG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45267 GTEX-W5WG-0008-SM-4KL25 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40679 NCIH1915 CCLE Cell Line Gene Expression Profiles 1.0 3.07017 ISG20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61431 KLHL15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22185 trochlear nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.960313 NCI-H647 COSMIC Cell Line Gene Mutation Profiles 1.0 null BGN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8952 H3K27ac_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HCC38 CCLE Cell Line Gene CNV Profiles 1.0 1.82166 MSL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51117 zona incerta, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.02572 PPIH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.89792 CREM-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null LD-37-JE11_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.207912 ELAVL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.97737 molecular_function GO Molecular Function Annotations 2015 1.0 null DDX53 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27041 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TE-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary motor cortex (area M1, area 4)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.0198 PMC4580625-pone.0138726.s006.xlsx-Immune_molecular_modules-PKNOX1_mod_PKNOX1 Rummagene Transcription Factor Associations 2026 1.0 null ISOC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94197 binding GO Molecular Function Annotations 2015 1.0 null H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Central lobule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.98101 Lobule III, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.22534 HCC2935 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.844387 TPM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25222 EFEMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50445 POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CFAP298 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.50696 POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FAM117A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42889 GTEX-OHPL-0006-SM-3MJHB GTEx Tissue Sample Gene Expression Profiles 1.0 1.4332 H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SU-DHL-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.16855 ST13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93631 RELA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.8333 Prostate adenocarcinoma_PRAD_TCGA-HC-7752-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null brain HPA Tissue Gene Expression Profiles -1.0 -1.32449 USF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF507 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59557 MXI1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE234340_9_v_7_muc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null FOXF2 JASPAR Predicted Transcription Factor Targets 1.0 null TRO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4896 POLR2A_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CUL4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.45047 GADD45G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57051 CTCF_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QLQW-0126-SM-447BK GTEx Tissue Sample Gene Expression Profiles 1.0 0.852396 Perturb_14788_OE_Slit2_SRP267596 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 17.0348 TGBC24TKB COSMIC Cell Line Gene Mutation Profiles 1.0 null ASNSD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55223 IRX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32525 PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-DMOG_-_HIF1A-gene_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null TM9SF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34906 H3K4me3_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE164874_5_v_12_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null USP46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67445 MEL-HO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.848882 dorsolateral (non-cerebellar) part of isA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42134 CHTF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76378 external part of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36698 FKBP14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95318 GALNT11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8805 Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M3-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Body Height DisGeNET Gene-Phenotype Associations 1.0 null parvicellular interstitial nucleus of the posterior commissure Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06983 GTEX-XUJ4-0008-SM-4BOQI GTEx Tissue Sample Gene Expression Profiles -1.0 -2.63889 GTEX-RTLS-0008-SM-48FET GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64595 LN340 DepMap CRISPR Gene Dependency 1.0 4.645 CNPY4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38773 retina BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.844183 H3K4me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-91-6828-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GPATCH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23139 PIP5KL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00767 KYSE270 CCLE Cell Line Gene CNV Profiles 1.0 1.43433 GSE95077_1_v_4_amiloride_human RummaGEO Drug Perturbation Signatures 1.0 null H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RK-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH526 CCLE Cell Line Gene CNV Profiles 1.0 1.96117 primary somatosensory cortex (area S1, areas 3,1,2)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.834909 TRMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.9685 SFMBT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1161 REC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44758 ADAT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69398 r6 part of the vestibular column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33931 GTEX-WL46-0011-R10A-SM-3MJFQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58648 MAZ_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE157282_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-TMMY-0926-SM-33HBG GTEx Tissue Sample Gene Expression Profiles 1.0 0.985475 RH30 DepMap CRISPR Gene Dependency 1.0 3.74992 CAL78 CCLE Cell Line Gene CNV Profiles 1.0 1.3945 ZNF660 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47914 hsa-miR-320d TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null CBLN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22188 H3K4me1_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-VUSG-0726-SM-3GIK1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29354 SRY-22984422-TESTIS-RAT ChEA Transcription Factor Targets 2022 1.0 null GTEX-XYKS-0526-SM-4BRW2 GTEx Tissue Sample Gene Expression Profiles 1.0 2.37946 HS 766T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.938802 UMUC7 DepMap CRISPR Gene Dependency 1.0 3.03657 Prostate GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.970311 medial part of r10B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13925 lung_3f HPA Tissue Sample Gene Expression Profiles 1.0 1.09657 SRD5A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02544 hsa-miR-875-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GSE180200,GSE180201_15_v_1_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCI-H1648 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.943735 Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A895-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-NJ-A55A-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PCGF4-22325352-293T-REX-HUMAN ChEA Transcription Factor Targets 2022 1.0 null hsa-miR-500a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 GSE202434,GSE202438_12_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UBE2F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62849 DRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22621 GSE157960_0_v_1_progesterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null mantle zone of r9Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02707 LTBR_INHIBITION - 3 Days_GDS2005_730_mouse_Lymph nodes (MG-430B) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-XOTO-0008-SM-4GICE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23622 PA-TU-8988T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08443 SIN3A ENCODE Transcription Factor Targets 1.0 null Rectum adenocarcinoma_READ_TCGA-DY-A1DF-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GLB1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09775 Bach1::Mafk JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 38.7982 ZMPSTE24_Deficiency_GDS3775_506_mouse_Embryonic fibroblasts GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null mantle zone of TG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54996 MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.1679 POLL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.25083 E2F3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9941 orbital frontal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12294 TEF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.55003 MYC-20876797-MEDULLOBLASTOMA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSTA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3277 GTEX-Q734-0626-SM-2I3EF GTEx Tissue Sample Gene Expression Profiles 1.0 1.78635 POLRMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84835 brain_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.54705 ETS1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55C-0008-SM-48FCF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02659 lateral reticular nucleus (principal part) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.09968 Adrenocortical carcinoma_ACC_TCGA-OR-A5KX-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null occipito-temporal gyrus, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.920415 KPNRTBM1 CCLE Cell Line Gene CNV Profiles -1.0 -2.16092 SK-OV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.33968 E2F6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32315 YMB1 CCLE Cell Line Gene CNV Profiles -1.0 -1.44668 LU-65 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-TML8-0008-SM-4DXUI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.68022 HELB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56073 JUP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68334 r9 part of spinal vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11622 GTEX-RM2N-0426-SM-2TF4T GTEx Tissue Sample Gene Expression Profiles 1.0 1.07615 Lung squamous cell carcinoma_LUSC_TCGA-56-7730-11A-01R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RNF225 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.48202 POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GCN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92297 GTEX-P4QS-0008-SM-48TDY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49289 FU-OV-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-XOT4-0008-SM-4B664 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25849 H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NL3H-0011-R3a-SM-2I3GL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.943805 CALR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90694 GTEX-RTLS-0926-SM-2TF5X GTEx Tissue Sample Gene Expression Profiles 1.0 2.67327 A3KAW CCLE Cell Line Gene Expression Profiles 1.0 1.38263 CTCF_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1 MotifMap Predicted Transcription Factor Targets 1.0 null NCI-H460 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.887996 GTEX-PWO3-0011-R6A-SM-2I5F3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08819 posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05294 GTEX-XUW1-0005-SM-4BOQ7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.24815 GTEX-QMR6-0008-SM-447AV GTEx Tissue Sample Gene Expression Profiles -1.0 -2.10483 UBA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95242 H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null OSGEP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43253 GTEX-X4XX-0005-SM-3NMCS GTEx Tissue Sample Gene Expression Profiles 1.0 1.01393 FECH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81011 CL-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.16453 Lymphoma_burkitts(Daudi) BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.836758 GTEX-QVJO-0008-SM-447AU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7821 A-431 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.933701 TRAF3IP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57659 GSE151829,GSE151831_1_v_0_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null mediodorsal nucleus of thalamus_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.80935 NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08891 PMC4944136-srep28995-s2.xls-ARGFX-gene_ARGFX Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S4Z8-0226-SM-4AD5K GTEx Tissue Sample Gene Expression Profiles 1.0 1.05515 NR2F2 ENCODE Transcription Factor Targets 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2872-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH23 DepMap CRISPR Gene Dependency 1.0 2.47848 Perturb_1822_KO_Irf5_SRP233379 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.86237 GSE171175,GSE171181_1_v_0_e7107_human RummaGEO Drug Perturbation Signatures 1.0 null KDM2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82467 Spinal nucleus of the trigeminal, oral part, middle dorsomedial part, dorsal zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47456 GTEX-S7SF-0006-SM-3K2B6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0845 CGRRF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20534 OVCA 429 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.68576 Dlx2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.4752 Perturb_3733_KO_Trp53_SRP296860 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.82645 cingulate gyrus, frontal part, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.860596 organelle LOCATE Predicted Protein Localization Annotations 1.0 null NCOA2_KO_GDS5087_24_mouse_heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE210885_2_v_1_klf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null BE2M17 DepMap CRISPR Gene Dependency 1.0 2.78116 GTEX-SJXC-0008-SM-4DM7G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.970435 PMC11528209-cd-23-1212_supplementary_table_s7_suppst7.xlsx-A549_EML4_KD_DEGs-List_of_DEGs_of_EML4-knockdown_vs_control_A549_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null TMEM125 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.896 MEX3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29703 A3KAW DepMap CRISPR Gene Dependency 1.0 2.16121 JHH-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null S100A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74397 PHF21A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82669 PMC8033524-EMMM-13-e13162-s004.xlsx-d_GREAT_on_NFIB_bound-genes_HF-Unnamed_0_NFIB Rummagene Transcription Factor Associations 2026 1.0 null cerebellar cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.45271 GTEX-RVPU-0008-SM-3NM8B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35094 NH6 CCLE Cell Line Gene CNV Profiles -1.0 -1.85997 ventral lateral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01382 medullary hindbrain (medulla) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.6788 GTEX-RU72-0008-SM-46MV8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64562 SYVN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98884 cellular_component LOCATE Curated Protein Localization Annotations 1.0 null GB-46-CK08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.587952 u87 HPA Cell Line Gene Expression Profiles -1.0 -1.8462 NSD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19707 VZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.59582 GTEX-OXRO-1726-SM-3LK6C GTEx Tissue Sample Gene Expression Profiles 1.0 1.87879 USP49 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24793 RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.07257 mantle zone of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.81845 ventrolateral part of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.002 AGPAT5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80033 GTEX-XBEW-0006-SM-4AT4E GTEx Tissue Sample Gene Expression Profiles 1.0 1.15269 OVTOKO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.881815 GTEX-X585-3026-SM-46MWF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.856675 MS751 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.929249 Choanomastigote TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.687 Pons, motor related Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05926 CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10055465-media-2.xlsx-ST15-Supplementary_Table_15_Bonferroni-significant_results_of_MAGMA_gene_based_association_analyses_EA_-_p_2_67e-06_0_05_18702_genes_AA_-_p_2_63e-06_0_05_18976_genes_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null u937 HPA Cell Line Gene Expression Profiles -1.0 -1.13926 membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null HSPB9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53726 POLR2AphosphoS5_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4352-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tectal gray formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.5482 GTEX-OIZH-0526-SM-2HMKV GTEx Tissue Sample Gene Expression Profiles 1.0 1.53631 GSE207122_1_v_0_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null CYB5RL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17952 Perturb_1111_KD_Creb3l1_SRP255011 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.07703 HEL9217 CCLE Cell Line Gene CNV Profiles 1.0 1.40664 GSE129244_3_v_5_lmo2_mouse RummaGEO Gene Perturbation Signatures -1.0 null SLC38A7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3514 MLF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86597 496100317_FWM_no dementia_no TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.53864 MZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.846803 superficial stratum of CoPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25083 Midbody COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.031 GSE111247_2_v_7_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-QMRM-0008-SM-447B1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0061 cervix uteri GTEx Tissue Gene Expression Profiles 1.0 0.961763 GTEX-QVUS-0011-R3A-SM-3GAFD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08554 GTEX-NL3H-0011-R1a-SM-48TDJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.980975 GSE225141,GSE225143_2_v_3_mettl3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QEL4-0008-SM-447AZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.991483 PMC4944136-srep28995-s2.xls-DUXA-gene_DUXA Rummagene Transcription Factor Associations 2026 1.0 null ARPC1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51296 GSE234340_10_v_7_muc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZMYM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33856 POLR2A_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHRNA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07018 POLR2A_lung_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-320c TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 SETD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57249 posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.18341 TMBIM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95519 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A42E-01A-11R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DYNC1LI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17983 EFM19 DepMap CRISPR Gene Dependency 1.0 2.10271 Sarcoma_SARC_TCGA-DX-A48J-01A-21R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DNASE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29043 GTEX-V1D1-0008-SM-4JBIJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13425 CLCN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26183 GTEX-R55E-0011-R5A-SM-2TC5N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05988 H3K4me3_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CAPAN-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.36465 NB7 DepMap CRISPR Gene Dependency 1.0 2.03027 DDX20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6159 ATG2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97498 APOBEC3F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.12656 Urinary tract TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Pancreatic adenocarcinoma_PAAD_TCGA-H8-A6C1-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MRGBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17353 Orbital area, ventrolateral part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02974 CDC42EP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30567 GSE109285_3_v_2_glucagon_mouse RummaGEO Drug Perturbation Signatures 1.0 null Dlx5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.599 GTEX-S7SE-0926-SM-2XCD6 GTEx Tissue Sample Gene Expression Profiles 1.0 2.25592 Perturb_16557_Mut_Brwd1_SRP116113 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 EA-09-HM95_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.200882 SIX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.35075 H3K4me3_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null EMC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58366 R3HDM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46643 H3118 DepMap CRISPR Gene Dependency 1.0 2.0687 SHPRH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01081 GTEX-XGQ4-0008-SM-4AT3Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4311 GTEX-X88G-0008-SM-47JWN GTEx Tissue Sample Gene Expression Profiles -1.0 -2.26063 TP63-23658742-EP156T-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Piriform-amygdalar area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14003 H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WHSB-0005-SM-3LK7C GTEx Tissue Sample Gene Expression Profiles 1.0 1.34475 Lung squamous cell carcinoma_LUSC_TCGA-43-6773-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.33819 medial portion of STH Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13637 CIZ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.63529 PANC1005 CCLE Cell Line Gene CNV Profiles -1.0 -1.42197 POLR2AphosphoS5_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null superior olivary complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.892427 GTEX-WVLH-3026-SM-3MJG9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06511 Presubiculum, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07018 dorsolateral SC part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27816 Perturb_4196_KD_Brd2/Brd3/Brd4_SRP226759 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.69856 GSE157960_0_v_3_progesterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-N7MT-0126-SM-2D7VT GTEx Tissue Sample Gene Expression Profiles 1.0 0.855138 LMNTD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29219 Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.06406 GTEx Esophagus 20-29 vs 70-79 GTEx Tissue-Specific Aging Signatures 1.0 6.02273 CBX3 ENCODE Transcription Factor Targets 1.0 null superficial stratum of CoPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26836 GTEX-VUSH-0005-SM-3NB2H GTEx Tissue Sample Gene Expression Profiles 1.0 1.01129 TDRD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57512 Perturb_4451_KO_Creb_SRP178474 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.18863 COX7C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16364 Orbital area, ventrolateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16008 19334046-TableS3b GeneSigDB Published Gene Signatures 1.0 null mantle zone of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14727 subparafascicular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.43464 OAZ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98409 H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X261-1026-SM-3NMDL GTEx Tissue Sample Gene Expression Profiles 1.0 1.25063 GSE131161_2_v_4_rarres1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QDT8-0008-SM-48U2F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1931 KLHL24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40915 IMPDH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84758 PCDHB14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.9368 Brain Lower Grade Glioma_LGG_TCGA-S9-A7J0-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r5 part of the oral Sp5 subnucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14727 inferior temporal gyrus, right, bank of mts Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08606 fallopian tube HPA Tissue Protein Expression Profiles 1.0 0.711602 PRM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45699 r5 basal plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48844 protein binding GO Molecular Function Annotations 2015 1.0 null ATP6V0C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24896 CHD1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SE5C-0006-SM-4BRW5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.54336 ATPAF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18833 POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null LZTS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9566 PLEKHA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55012 cerebellar cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.03623 CCNY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02165 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IK-01A-12R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A82C-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-XXEK-0005-SM-4BRWJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.954952 GTEX-U412-0008-SM-4DXTE GTEx Tissue Sample Gene Expression Profiles -1.0 -2.19652 SW 1990 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.30445 Brain Lower Grade Glioma_LGG_TCGA-DU-A6S7-01A-21R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null METTL16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72314 fallopiantube_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.60134 H3K9ac_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null QKI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83771 COPS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15546 ZDHHC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5661 JHH-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.924423 GTEX-OHPM-0006-SM-2HMKU GTEx Tissue Sample Gene Expression Profiles 1.0 1.42829 r6 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.81971 GTEX-WK11-0526-SM-3NB3O GTEx Tissue Sample Gene Expression Profiles 1.0 1.61248 CDR2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43382 cingulum bundle, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.61736 GTEX-X88G-0006-SM-47JX5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04321 NTERA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.5749 CACO-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.999141 GOT1L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77042 NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RM2N-0006-SM-2TF5H GTEx Tissue Sample Gene Expression Profiles 1.0 1.15893 RBCK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01482 ASPC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.50201 GSE60217_1_v_2_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null NCIH1092 CCLE Cell Line Gene CNV Profiles 1.0 3.02549 STAT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55882 Weight Loss CTD Gene-Disease Associations 1.0 1.267 JEKO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.5768 H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XMK1-0008-SM-4GICF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07819 deltaEF1 MotifMap Predicted Transcription Factor Targets 1.0 null GSE202434,GSE202438_10_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-R53T-0226-SM-48FEH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.828692 Obstructive lung disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.732 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5VV-06A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null molecular layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.35259 anterior pretectal nucleus, ventral superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54646 GTEX-NL3H-0011-R10A-SM-2I3E9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12857 MEN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54711 ARHGEF39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79003 CC-17-JL38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.285157 Anterior olfactory nucleus, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0929 reticular nucleus of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.44532 TRIM23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.36486 CEP72 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05569 NALM-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.34459 primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.37359 PMC12700831-41594_2025_1680_MOESM4_ESM.xlsx-D9_MC_Hits_2_5FC_CRAPomeFilt-Mapped_Gene_Symbol_CENPX Rummagene Transcription Factor Associations 2026 1.0 null SKNBE2 CCLE Cell Line Gene CNV Profiles -1.0 -1.70903 GSE154074_1_v_0_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null K-562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.957275 Perturb_5981_KD_XRN2_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.56462 CHMP7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28634 GSE120612_7_v_0_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null COR-L26 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.40859 496100528_FWM_no dementia_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.4456 Sarcoma_SARC_TCGA-PC-A5DL-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Peripheral_Blood_Mononuclear_Primary_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.82497 Purkinje cell layer of CbVCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13484 mantle zone of r5Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16407 r6 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.6788 CAMKMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.75574 placenta HPA Tissue Gene Expression Profiles -1.0 -0.876384 BT483 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.16789 ACTG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23436 HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.45759 GRK6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36244 ADAM10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12608 bewo HPA Cell Line Gene Expression Profiles 1.0 1.62671 ZNF816 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 49.6097 short insular gyri, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.824294 CD4_Memory_Primary_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.1668 GSE168604,GSE183859_1_v_0_selumetinib_human RummaGEO Drug Perturbation Signatures -1.0 null PKD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04834 HCC827 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34555 Vdr JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.26 H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Basolateral amygdalar nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00657 CHP-212 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.17226 GTEX-RU1J-0006-SM-2TF6M GTEx Tissue Sample Gene Expression Profiles 1.0 1.06029 HCC1493 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.912715 SETDB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06791 Lung adenocarcinoma_LUAD_TCGA-99-8025-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ESR2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.074 GTEX-OIZH-3026-SM-3NB1G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.889495 LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null SA1-27219007-CHIP-SEQ-ERYTHROID-HUMAN ChEA Transcription Factor Targets 2022 1.0 null UBE2G1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.04511 GTEX-TSE9-0008-SM-4DXT8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18131 Ciliated cell_Trachea_Mouse CellMarker Gene-Cell Type Associations 1.0 null SLC7A5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32947 H3K36me3_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFON-0426-SM-3GIL4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.17688 GTEX-RWSA-1126-SM-2XCAZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.825053 H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Hematocrit GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.35229 hippocampus (hippocampal formation)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.9781 CCDC142 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54606 JMJD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.97388 Superior colliculus, motor related, deep white layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25915 Midbrain trigeminal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38519 SGSM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59247 496100554_FWM_no dementia_no TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.2504 537 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.932045 MPP89 CCLE Cell Line Gene Expression Profiles -1.0 -1.53547 CNMD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02791 peripeduncular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19859 iPS-20b Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 0.942525 ZNF669 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50924 GTEX-S7PM-0008-SM-3NM9Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59158 JURKAT DepMap CRISPR Gene Dependency 1.0 2.69489 HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.02725 496100277_FWM_no dementia_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.10728 GTEX-UTHO-0008-SM-4JBID GTEx Tissue Sample Gene Expression Profiles -1.0 -1.95091 SHARPIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2236 GTEX-QESD-0626-SM-2I5G4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09042 GSE149123,GSE149128_1_v_0_cdk7_mouse RummaGEO Gene Perturbation Signatures -1.0 null bronchus HPA Tissue Protein Expression Profiles 1.0 0.711602 PA1 DepMap CRISPR Gene Dependency 1.0 2.06203 PRR13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66205 ZNF592 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74869 medial part of r6B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.02233 H3K4me3_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null LASP1NB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80581 CML-T1 COSMIC Cell Line Gene Mutation Profiles 1.0 null subthalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10851 PL45 CCLE Cell Line Gene CNV Profiles -1.0 -1.5366 KIAA0753 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38255 EIF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88651 MAX ENCODE Transcription Factor Targets 1.0 null RTCB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94591 POLR2A_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5794-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE233647_4_v_6_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null BID CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18601 A3/KAW Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22279 NR2F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 62.7518 ZEB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4742 HCC38 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.753737 nb4 HPA Cell Line Gene Expression Profiles 1.0 1.06483 posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.28299 TGFBR2_knockout_292_GSE46150 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.52789 GTEX-OHPN-2726-SM-2I5H4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.857002 IRX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97114 L-1236 COSMIC Cell Line Gene Mutation Profiles 1.0 null U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.24201 ZNF540 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12236 granular layer of caudal dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01863 H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HNF4A_KD_GSE29084_694_human_HepG2 cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null TNFRSF11A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39612 PIP4K2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54834 cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.83484 PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context3-Nearest_Ensembl_ATF3 Rummagene Transcription Factor Associations 2026 1.0 null Fog2_KO_GDS3659_152_mouse_adult heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Lobule III Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.14057 cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 3.4231 GTF3C3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38136 NCI-N417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.826206 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5085-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ATR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83225 HCC70 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.09859 HUH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.91808 SLC46A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58285 SG in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.37582 heart_5a HPA Tissue Sample Gene Expression Profiles -1.0 -1.04946 REST ENCODE Transcription Factor Targets 1.0 null IPC-298 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.5257 FARP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.43595 ZNF668 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85367 central gray of the pons, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.40893 GTEX-S3XE-0008-SM-3NM8O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23316 core part of DTg Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.002 PRKAB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5792 HMGN3 ENCODE Transcription Factor Targets 1.0 null GTEX-OHPL-0326-SM-33HC8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.880687 GR-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34555 MDAMB175VII CCLE Cell Line Gene CNV Profiles -1.0 -1.66168 midbrain reticular formation Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.27102 ARMC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20539 GTEX-U412-0826-SM-3DB9K GTEx Tissue Sample Gene Expression Profiles 1.0 1.79881 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null YIPF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44068 Head TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Orbital area, lateral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03478 periventricular stratum of Ist Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25628 GTEX-X3Y1-0626-SM-3P5YS GTEx Tissue Sample Gene Expression Profiles 1.0 2.3726 Fetal Lung Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.40972 GSKIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36269 amygdaloid complex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.967831 NFKB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03179 outer CP in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.981553 Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A9FL-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inner SZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.856903 layer I of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.63989 GTEX-N7MS-0926-SM-2HMIZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.0163 JADE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27103 TLK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54787 PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null midline nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.942348 Lung adenocarcinoma_LUAD_TCGA-55-8513-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T5JW-0326-SM-4DM6J GTEx Tissue Sample Gene Expression Profiles 1.0 1.90474 SRSF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47866 GTEX-T6MN-0011-R7A-SM-32QP5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.849301 HS 839.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.13208 raphe obscurus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.33744 EIF1AD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.13206 H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 496100576_HIP_dementia_TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.01105 H2BC15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07314 LGR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36066 upper (rostral) rhombic lip_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.22978 GTEX-T5JC-0011-R10A-SM-32PM2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.974372 GTEX-SNOS-0008-SM-4DM6I GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50218 NR0B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7851 COV318 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.966816 NCI-H1975 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.915874 PRRG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82013 CXCL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90531 CBX2-22325352-293T-REX-HUMAN ChEA Transcription Factor Targets 2022 1.0 null EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GY-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superior temporal gyrus, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.862998 REST_PFSK-1_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Orbital area, lateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42537 C-33-A COSMIC Cell Line Gene Mutation Profiles 1.0 null NR4A2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.3288 GSE116354,GSE117379_2_v_4_cox2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H2BC12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79144 NCOA2_KO_GSE41558_19_mouse_heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null NCI-H2135 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.50129 Perturb_5141_KO_Rn7sk_ERP002405 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.56202 CAMSAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35274 BAHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78393 MAGED2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.50345 YAPC CCLE Cell Line Gene Expression Profiles -1.0 -1.70963 Lef1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.8881 SUM149PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.93053 Prostate adenocarcinoma_PRAD_TCGA-ZG-A8QW-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MOB3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56753 IC-28-HS37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.277524 TRMT10C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57922 HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12455829-11658_2025_792_MOESM8_ESM.xlsx-2_DDIT3_IP_vs_BRG1_IP-Unnamed_2_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null SNU-719 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.894387 COLO-320-HSR COSMIC Cell Line Gene Mutation Profiles 1.0 null RBPMS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8037 NHLF Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.838356 H3K4me1_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null ZGLP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09025 PDK1_knockout_80_GSE26290 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 0.131123 NDN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54462 Heart BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.4792 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70Q-01A-13R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIN3A ChEA Transcription Factor Targets 1.0 null intermediate part of r5B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22593 MZ in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.81685 FGF21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23691 GSE143406_1_v_0_carfilzomib_human RummaGEO Drug Perturbation Signatures 1.0 null GUK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73592 rhombomere 10 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.8656 DENND10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95531 PMC8387919-mmc2.xlsx-ST9_NEUROG3_bound_TF_genes-Supplemental_Table_9_NEUROG3_bound_TFs_genes_NEUROG3 Rummagene Transcription Factor Associations 2026 1.0 null Anterodorsal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.78666 primary auditory cortex (core)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.870462 CEP41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.75812 H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PAGE4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.45006 DGCR6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.321 lateral part of alar m1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1168 NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.40801 Lung adenocarcinoma_LUAD_TCGA-55-8621-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SLITRK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9333 SIN3A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JEKO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.936161 DB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.886184 H3K4me1_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RXRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.7785 SOCS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87839 GTEX-WWYW-0005-SM-3NB3K GTEx Tissue Sample Gene Expression Profiles 1.0 0.947364 N4BP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60056 GTEX-OHPK-0006-SM-2HMKH GTEx Tissue Sample Gene Expression Profiles 1.0 0.842442 midbrain raphe nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.960819 SK-NEP-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-M8-A5N4-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4802-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Dendritic spine head COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.956 SG in dysgranular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.30369 KE39 CCLE Cell Line Gene CNV Profiles 1.0 1.34341 MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25109 RPA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16936 OE33 CCLE Cell Line Gene CNV Profiles -1.0 -1.39113 IMR-32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.60635 LAMTOR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82828 OGFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80339 Cardiovascular system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.061 PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2 Rummagene Transcription Factor Associations 2026 1.0 null AOB, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17041 ChIP_JARID1A_20064375 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GSE196117_1_v_0_clarithromycin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-NPJ7-0011-R1a-SM-3GACT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.859707 GSE214212_2_v_0_chd6_human RummaGEO Gene Perturbation Signatures -1.0 null PMC12455829-11658_2025_792_MOESM8_ESM.xlsx-2_DDIT3_IP_vs_BRG1_IP-Supplementary_Table_7_Transcription_factors_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OXRK-0008-SM-3NB28 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.984038 Medial septal complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23523 rostral (anterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.83609 GTEX-Q2AI-0006-SM-2I3FG GTEx Tissue Sample Gene Expression Profiles 1.0 0.903116 NR6A1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.3698 GTEX-WYJK-0826-SM-3NM8Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.32476 GTEX-OXRO-0011-R9A-SM-3NB1X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.847853 496100455_FWM_dementia_TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.59618 posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.50178 AGS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.925354 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4981-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null striatum_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.93236 rostral subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.78052 Perturb_6956_KO_Tefm_SRP114827 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.60907 GEMIN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67732 GATA1_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X62O-0008-SM-46MU5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.949403 HOXD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05563 GTEX-RNOR-0011-R7A-SM-2TF4V GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38287 ZR751 CCLE Cell Line Gene CNV Profiles -1.0 -1.52166 MARS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66308 medial part of r5B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.77813 Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A8HX-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210770_0_v_1_foxp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCIH1876 CCLE Cell Line Gene CNV Profiles 1.0 1.63046 Brain Lower Grade Glioma_LGG_TCGA-FG-A4MX-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLC66A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33752 C80 DepMap CRISPR Gene Dependency 1.0 5.92242 POLR2A_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE162892_4_v_0_isox_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XAJ8-0006-SM-46MVM GTEx Tissue Sample Gene Expression Profiles 1.0 1.47531 GTEX-XMD1-0006-SM-4AT4Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.91071 NCCIT COSMIC Cell Line Gene Mutation Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LS-01A-22R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-FV-A3I1-11A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TENT4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06558 NPIPA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.67303 B4GAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67524 lateral tuberal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.35127 PSMF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27159 GTEX-SSA3-0008-SM-47JWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -3.00234 GTEX-XPVG-0626-SM-4B65B GTEx Tissue Sample Gene Expression Profiles 1.0 0.942391 MFM-223 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.45759 HS 940.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.5257 TCEAL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.99162 GLS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15585 ZNF569 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59402 GTEX-S4Z8-0008-SM-33HAZ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.02004 STK38L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74882 m2 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.96926 H3K4me1_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H3K36me3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE196343_1_v_0_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27ac_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null INTS13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.20359 POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EXOG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47601 HEXD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26687 RKN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.21606 GTEX-X5EB-2226-SM-46MW4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.955049 GTEX-Q2AG-0526-SM-2S1PW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.868998 periventricular stratum of isLim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33032 outer SZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.958834 CAL-12T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.930477 ORAI3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45749 ESRP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62265 Acute Myeloid Leukemia_LAML_TCGA-AB-2897-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BACH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6649 cuneiform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66858 Body mass index GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.909691 PIWIL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29146 JHH-6 COSMIC Cell Line Gene Mutation Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A8IH-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TWF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50391 ZNF384_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWOO-0006-SM-2I3E3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.908399 SG in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00171 PPP1R15B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39962 TBC1D23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12959 occipito-temporal gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.857481 GTEX-NL3H-0011-R7a-SM-2I3G5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05554 TMEM14A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64407 Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A6ZA-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lingula (I), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31728 BRDT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04868 Kidney Chromophobe_KICH_TCGA-KL-8327-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medial orbital gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.979459 KYM1 DepMap CRISPR Gene Dependency 1.0 2.54573 Sarcoma_SARC_TCGA-X6-A8C5-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SLC22A17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64929 ZNF443 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67201 AVL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15831 NFYA-21822215-K562-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A97Q-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NR2F2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUZC-0426-SM-4BOPE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.838505 GSE215351,GSE215794_4_v_3_kdm8_mouse RummaGEO Gene Perturbation Signatures -1.0 null KIFC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50637 CNBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.10236 GTEX-R55E-0011-R1A-SM-2TC6N GTEx Tissue Sample Gene Expression Profiles -1.0 -0.930375 FERD3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09106 PGD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98568 SMS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1784 LTBR_INHIBITION - 27 Day_GDS2005_731_mouse_Lymph nodes (MG-430B) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-QMRM-0826-SM-3NB33 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2185 Bed nuclei of the stria terminalis, anterior division, ventral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19944 LCMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99876 TMEM238 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85763 SOX10 MotifMap Predicted Transcription Factor Targets 1.0 null NLE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51904 occipital pole, left, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.25563 GSE158431_2_v_0_pioglitazone_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE213588_9_v_13_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null BLZF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.5888 H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC12281655-CPB-26-6-935_SD1.pdf-15-TBX20_TBX20 Rummagene Transcription Factor Associations 2026 1.0 null SK-MEL-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12287 496100611_FWM_no dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.03429 Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41R-01A-21R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.960678 Perturb_12647_KD_Dirc3_SRP191022 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 MED30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46039 GTEX-N7MS-0008-SM-4E3JI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7853 Frontal pole, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13795 RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.916613 A1207 CCLE Cell Line Gene Expression Profiles -1.0 -1.8359 MED14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73641 H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OXRO-1226-SM-48TDL GTEx Tissue Sample Gene Expression Profiles 1.0 0.887135 primary auditory cortex (core)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.07723 GSK3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30996 SLC26A11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65616 MYC_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Chronic obstructive pulmonary disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.732 Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.42183 anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.26989 GSE102467_3_v_0_pazopanib_human RummaGEO Drug Perturbation Signatures 1.0 null Height GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.2699 POLR2AphosphoS5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null C11orf87 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98306 layer III of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.838223 mantle zone of r6Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33931 Bed nuclei of the stria terminalis, anterior division, rhomboid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36104 POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SERPINB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65278 SPRY4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77503 MDST8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.29752 HCC70 CCLE Cell Line Gene CNV Profiles 1.0 1.34608 GSE136622_2_v_3_srpk3_mouse RummaGEO Gene Perturbation Signatures 1.0 null SLC38A10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96081 GTEX-QXCU-0008-SM-48FCH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.958371 U2OS DepMap CRISPR Gene Dependency 1.0 2.84569 Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-A8I2-01A-12R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SKMM2 CCLE Cell Line Gene CNV Profiles -1.0 -2.0397 paracentral lobule, posterior part, right, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.07512 GFER CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47354 REXO4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.02424 H3K27ac_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 496100562_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.55465 MFSD6L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05867 GTEX-S33H-0008-SM-4AD6C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45916 H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null WDR77 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8158 TCF7L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98532 GTEX-S7SE-0008-SM-33HB1 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.2953 ADM5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18578 GSE146687_2_v_5_eribulin_human RummaGEO Drug Perturbation Signatures 1.0 null MTR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23855 SNU245 CCLE Cell Line Gene CNV Profiles -1.0 -1.41037 NARS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86605 POLR2A ENCODE Transcription Factor Targets 1.0 null RCM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25147 C2BBE1 DepMap CRISPR Gene Dependency 1.0 3.22175 RFX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.603 H3K4me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null choroid plexus of the fourth ventricle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.96859 inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.81273 CREM-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GNAI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.21415 DICER1_KO_GDS4504_584_mouse_bone marrow granulocyte-macrophage progenitors GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-U412-0006-SM-3DB8J GTEx Tissue Sample Gene Expression Profiles 1.0 0.982531 GTEX-OIZH-0005-SM-2HMJN GTEx Tissue Sample Gene Expression Profiles 1.0 1.07273 FOXA1-27270436-CHIP-SEQ-PROSTATE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5ED-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QCQG-0006-SM-2S1OW GTEx Tissue Sample Gene Expression Profiles 1.0 1.34965 Perturb_12130_KO_Ldb1_SRP136181 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.04674 PMC6879454-Data_Sheet_1.xlsx-AA_disease-Unnamed_4_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null APH1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.46543 HS688AT CCLE Cell Line Gene Expression Profiles -1.0 -2.42005 MCCC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.08087 GPR75 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65059 PKP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.46936 ZNF773 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29087 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51H-06A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE180800,GSE180801_0_v_5_tex10_mouse RummaGEO Gene Perturbation Signatures 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9R7-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDAMB134VI CCLE Cell Line Gene Expression Profiles -1.0 -2.19996 GTEX-UJMC-0008-SM-4IHKK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19452 external granular (germinal) layer of lower rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.84154 parolfactory gyri, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.93827 ARHGAP45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27902 H3K36me3_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Fetal Kidney Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.26933 GSE87412,GSE92423_0_v_1_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null CLDN11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67134 MT-ND4L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28111 MAP4K4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58107 HCC1576 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.05089 H3K9me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SW780 CCLE Cell Line Gene Expression Profiles 1.0 1.81598 XAB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62171 DAB2IP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.52695 GTEX-XMD1-0526-SM-4AT4Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.922022 CALM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98828 superficial stratum of PO1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1897 GTEX-R53T-0008-SM-48FEW GTEx Tissue Sample Gene Expression Profiles -1.0 -2.27373 GTEX-RUSQ-1926-SM-2TF6K GTEx Tissue Sample Gene Expression Profiles -1.0 -0.848817 CDX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29339 ZNF140 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 60.8875 rhombomere 8 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06572 PWWP3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62611 GTEX-NL4W-0011-R6a-SM-2I3GA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.858949 Brain Lower Grade Glioma_LGG_TCGA-VM-A8C8-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Rectum adenocarcinoma_READ_TCGA-DY-A1DG-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ED-A8O6-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COR-L23 COSMIC Cell Line Gene Mutation Profiles 1.0 null COLO 829 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08366 GTEX-UTHO-0006-SM-3NMCC GTEx Tissue Sample Gene Expression Profiles 1.0 1.02695 Perturb_3998_KD_RIOK3_SRP116196 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE111247_2_v_1_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null VZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.969171 NCIH209 CCLE Cell Line Gene CNV Profiles -1.0 -2.41021 GTEX-OHPL-3026-SM-3MJGS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.979486 GTEX-POYW-0826-SM-2XCEM GTEx Tissue Sample Gene Expression Profiles 1.0 1.33143 SRSF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.21403 H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SPATA2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22665 GTEX-WVLH-0011-R10A-SM-3MJFM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00515 RGS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03144 ALDH6A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68025 GSE154074_1_v_4_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null PMC10117100-msphere.00056-23-s0008.xlsx-2B-Supplementary_Table_S2B_mRNAseq_analysis_genes_significantely_downregulated_upon_E2F4-5_knockdown_in_38HK_E2F4 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-R55D-0008-SM-48FEV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43177 Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QF-01A-31R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nucleus LOCATE Predicted Protein Localization Annotations 1.0 null FOXP1_01_210 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59333 SET-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.63349 COMMD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15643 ZNF816 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22715 GTEX-WEY5-0008-SM-4LMKC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27204 superficial stratum of r7Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.50355 STAT4 MotifMap Predicted Transcription Factor Targets 1.0 null TTC21B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30677 BHLHE40_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1534 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.16627 POLR2A_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LSM12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55621 DPP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12565 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YI-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SEMA4F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88463 MAT1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71858 hsa-miR-320b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 NCIH1355 CCLE Cell Line Gene Expression Profiles 1.0 1.43499 RMG-I Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.999809 H3K27ac_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null POLE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8369 Hmx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.3969 SMCO4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70044 outer plexiform zone in extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.890961 parabrachial part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.45968 A549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.915874 SUDHL10 DepMap CRISPR Gene Dependency 1.0 2.65492 NINL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71567 GTEX-SJXC-1226-SM-4DM78 GTEx Tissue Sample Gene Expression Profiles 1.0 0.979192 medial part of r9B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3061 ZNF45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39758 GTEX-XGQ4-0826-SM-4AT4T GTEx Tissue Sample Gene Expression Profiles 1.0 0.984822 RET_knockout_270_GSE32093 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.29157 cell part LOCATE Curated Protein Localization Annotations 1.0 null GTEX-P4PQ-2626-SM-33HC9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.830129 Acute Myeloid Leukemia_LAML_TCGA-AB-2927-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null globus pallidus, external segment, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19314 ETV2-25802403-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-O5YW-0008-SM-4E3IE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25401 arcuate nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05476 Pancreas Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.827889 AC-76-JB92_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.314809 frontal pole, left, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.8786 DDX31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.28995 Ciliary tip COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.385 POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null fallopiantube_8c HPA Tissue Sample Gene Expression Profiles 1.0 2.64217 ZNF341 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.9132 WASF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.60941 GTEX-XQ8I-1726-SM-4BOQB GTEx Tissue Sample Gene Expression Profiles 1.0 1.24758 GTEX-TMMY-0008-SM-4DXU3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26738 parabrachial complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.81934 Lung squamous cell carcinoma_LUSC_TCGA-22-4605-01A-21R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SLC7A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33131 CTCF_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPL-0426-SM-3TW8X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.866105 EARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00867 BEN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.938802 mantle zone of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.75735 14581339-SuppTable6 GeneSigDB Published Gene Signatures 1.0 null SLC20A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23619 SNTB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21893 COLO 699 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.904465 GSE118765_1_v_5_rreb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null smoothmuscle_8b HPA Tissue Sample Gene Expression Profiles -1.0 -1.40287 INIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57183 GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00494 COL4A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48606 GTEX-R55G-0008-SM-48FEX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28883 496100484_FWM_no dementia_no TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.37687 ventrolateral prefrontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.869241 HCC827GR5 DepMap CRISPR Gene Dependency 1.0 2.17927 GSE224969,GSE224971_3_v_1_chtop_mouse RummaGEO Gene Perturbation Signatures 1.0 null RAG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2346 superior colliculus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.31879 GSE196117_6_v_0_clarithromycin_human RummaGEO Drug Perturbation Signatures 1.0 null GRAMD1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.73452 PGAM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98235 PDK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36015 Cortical thickness (MOSTest) GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.0 OSBPL1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76485 primary auditory cortex (core)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.890461 SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUM102PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.70312 G112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.44657 CREM ChEA Transcription Factor Targets 1.0 null GTEX-S7SF-0008-SM-3NM8T GTEx Tissue Sample Gene Expression Profiles -1.0 -2.32234 HCFC1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.60184 Aorta Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -2.73029 paraterminal gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.07619 MYC ENCODE Transcription Factor Targets 1.0 null RH28 DepMap CRISPR Gene Dependency 1.0 2.38055 anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.103 Medulla, motor related Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1812 Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A47N-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null USF2 ENCODE Transcription Factor Targets 1.0 null Rectum adenocarcinoma_READ_TCGA-DY-A1H8-01A-21R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-WY-A85C-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CAMA-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.6796 VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.35197 GTEX-S4Q7-0008-SM-3NM8A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24303 PGBD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36596 STK26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17161 PIAS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46308 Sox1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.4354 NDRG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03107 GTEX-NL4W-0011-R10A-SM-2I3DY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.984001 H3K4me1_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SN8G-0008-SM-4DM4X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33263 GTEX-XUZC-0005-SM-4BOQ8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04463 SP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.93283 PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context3-Gene_Name_ATF3 Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10703699-41588_2023_1554_MOESM3_ESM.xlsx-T6D_mageckTFkoscreen_with_BATF3-gene_BATF3 Rummagene Transcription Factor Associations 2026 1.0 null MPC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54159 BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MEA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81546 EIF2B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74606 GD-66-XE49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.286985 MRPS12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55971 YAPC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.31285 GTEX-OOBJ-0008-SM-3NB26 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51132 periventricular stratum of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.11245 POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRKAG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64943 GTEX-UPK5-0008-SM-4IHJD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11382 GTEX-P4PP-0326-SM-33HC4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.826773 SLC25A51 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92592 MELHO DepMap CRISPR Gene Dependency 1.0 3.06436 POLR2A_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WZTO-0011-R4A-SM-3NMC7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.917618 LUC7L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01096 H3K4me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null ZBTB17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34667 TMEM69 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57438 RNF207 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92699 GSE214212_3_v_1_chd6_human RummaGEO Gene Perturbation Signatures 1.0 null dorsolateral part of Lat Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.552 GTEX-XMD3-0008-SM-4AT4V GTEx Tissue Sample Gene Expression Profiles -1.0 -1.65014 central glial substance Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 3.26578 Orbital area, medial part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13416 Piriform-amygdalar area, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00478 AGXT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.49361 Dentate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26395 GTEX-S341-0826-SM-4AD73 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01422 TCTN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11735 H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles 1.0 1.25088 SET-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.67242 mantle zone of r5BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24484 Perturb_10316_KO_Cox10_SRP155323 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.34847 FBXL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.54806 MAZ ENCODE Transcription Factor Targets 1.0 null Runx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.4685 Brain Lower Grade Glioma_LGG_TCGA-TM-A84H-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HSC-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null Mouth TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GTEX-PWOO-0726-SM-2I3EB GTEx Tissue Sample Gene Expression Profiles 1.0 1.96614 GSE116354,GSE117379_3_v_5_cox2_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2AphosphoS5_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WEY5-2126-SM-3GILK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.65549 GTEX-P44H-1126-SM-48TBU GTEx Tissue Sample Gene Expression Profiles 1.0 2.059 ALDOC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56273 GSE157594_0_v_4_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null ZNF518A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.01442 layer 1 of FCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04689 Brain morphology (min-P) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.752288 BLOC1S1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7421 ZNF609 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52911 KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_14003_OE_Kcna2_SRP309478 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.17843 MAP1LC3B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98488 CXADR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77458 IMR32 CCLE Cell Line Gene CNV Profiles -1.0 -2.67667 LS1034 CCLE Cell Line Gene CNV Profiles -1.0 -1.38735 DCAF12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02689 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RM-A68W-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NANOG-20526341-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-P78B-0008-SM-48TE1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27962 GTEX-X4XX-0008-SM-46MVK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12965 CI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.933701 fastigial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.03258 COV318 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.976005 GTEX-OHPM-0008-SM-4E3IP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19721 NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.76568 urinary bladder HPA Tissue Protein Expression Profiles 1.0 1.30122 CEMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70205 GTEX-RNOR-1426-SM-48FDJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.37031 NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01489 EW-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_16730_KO_Pin1_SRP069191 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.06776 ARHGEF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66677 lung_4d HPA Tissue Sample Gene Expression Profiles 1.0 0.971245 GSE180200,GSE180201_15_v_11_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2AphosphoS2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RUNX2-24655370-MC3T3E1-MOUSE-BONE ChEA Transcription Factor Targets 2022 1.0 null CB-31-UO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.284877 GTEX-P44H-0008-SM-48TDW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51015 GTEX-PWN1-0008-SM-48TEA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50522 H4K20me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HDAC1 ENCODE Transcription Factor Targets 1.0 null Perturb_15286_KO_Trp73_SRP067006 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.62962 GTEX-POYW-0008-SM-48TE4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28331 YMB-1-E Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.4161 CAMA-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.999098 H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T6MO-1426-SM-4DM73 GTEx Tissue Sample Gene Expression Profiles 1.0 1.93903 ZNF418 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 66.9733 Lung squamous cell carcinoma_LUSC_TCGA-98-A53H-01A-12R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15071 NCI-H1650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.0059 U118MG DepMap CRISPR Gene Dependency 1.0 2.03977 CAMA1 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.92632 GTEX-PLZ4-0006-SM-2S1NY GTEx Tissue Sample Gene Expression Profiles 1.0 0.828501 KNS42 CCLE Cell Line Gene CNV Profiles -1.0 -1.37108 POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBEW-0226-SM-4AT6A GTEx Tissue Sample Gene Expression Profiles 1.0 3.34784 MED28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.66742 Radial spoke head COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.105 LIG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68769 POLR2AphosphoS2_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPIC-0005-SM-3GACV GTEx Tissue Sample Gene Expression Profiles 1.0 1.15006 lung_3e HPA Tissue Sample Gene Expression Profiles 1.0 1.28483 DUSP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57228 orbital frontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.864026 IM-95M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.850685 496100479_FWM_no dementia_TBI_89_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.12916 KPNA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41441 GTEX-WWYW-0926-SM-3NB2Z GTEx Tissue Sample Gene Expression Profiles 1.0 2.78179 HNF4alpha_DEPLETION_GDS4798_91_human_HepG2 hepatocellular carcinoma cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null cingulate gyrus, retrosplenial part, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.26815 POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.884294 UM-UC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.915874 HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.59277 VIM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20435 Anterior olfactory nucleus, external part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44888 RFX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.0037 POLR2AphosphoS5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RS5 CCLE Cell Line Gene Expression Profiles -1.0 -1.82914 Perturb_4896_KD_NCBP1_SRP160510 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.38185 H4K20me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.26465 HPAC CCLE Cell Line Gene Expression Profiles 1.0 1.93407 Brain_Germinal_Matrix Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.05877 Lingula (I) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38605 Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.061 NCI-H1355 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00383 SARS-CoV_60Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.56164 GTEX-T6MN-0011-R2A-SM-32QOW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.958674 Lung squamous cell carcinoma_LUSC_TCGA-22-5471-11A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LS1034 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20073 SERF1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61354 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A5SJ-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-8309-11A-01R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FR-A7UA-06A-32R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null C5orf15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12092 VZ in postamygdaloid region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.22454 OVCAR433 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08891 GTEX-QEG4-0008-SM-48TYZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46155 KNTC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27656 COQ3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73815 PSEN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42544 MRTFA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65115 DPY19L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53082 KOSC-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE137325_2_v_0_copanlisib_human RummaGEO Drug Perturbation Signatures 1.0 null SCN5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42733 EFO27 DepMap CRISPR Gene Dependency 1.0 2.47965 PA-TU-8988T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.942651 PPT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36743 GSE140937,GSE140938_0_v_2_slfn11_human RummaGEO Gene Perturbation Signatures 1.0 null ZBTB22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84917 EN COSMIC Cell Line Gene Mutation Profiles 1.0 null intermediate stratum of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55905 Thymus BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.962191 GTEX-NFK9-0726-SM-2HMJW GTEx Tissue Sample Gene Expression Profiles 1.0 1.0269 PRKACA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64502 NCI-H847 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.839573 ZFAND6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31598 PABPC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21547 GTEX-NPJ7-0011-R10A-SM-2I3E5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00167 H3K4me3_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC5918774-13287_2018_864_MOESM2_ESM.xls-sheet-AF_MSC_AND_UM51_MSC Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HSF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38398 GTEX-U3ZH-0008-SM-4DXT2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.75226 Nfat5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.1264 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4833-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SOX10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26238 Skin Cutaneous Melanoma_SKCM_TCGA-FR-A3YN-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ITGB3BP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22711 GTEX-X4EO-0926-SM-3P5Z2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.994979 GTEX-WFJO-0005-SM-3GIKY GTEx Tissue Sample Gene Expression Profiles 1.0 1.39194 SUM 1315M02 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.95943 GTEX-XLM4-0011-R8A-SM-4AT44 GTEx Tissue Sample Gene Expression Profiles 1.0 1.16382 KYSE-270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03248 CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ4-0008-SM-48TE6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78297 YEATS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78897 dorsomedial preoptic area, superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1897 ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.24614 HSF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86488 SW48 COSMIC Cell Line Gene Mutation Profiles 1.0 null VPS37D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95311 KLHL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65758 primary somatosensory cortex (area S1, areas 3,1,2)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.26098 rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.971028 GTEX-RU72-0011-R5A-SM-2TF6U GTEx Tissue Sample Gene Expression Profiles -1.0 -0.989837 TD-29-IN36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.25886 SUIT2 DepMap CRISPR Gene Dependency 1.0 2.21264 H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QVJO-0011-R6A-SM-2S1QN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.857157 LPS6 DepMap CRISPR Gene Dependency 1.0 2.9083 L-363 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.07787 THAP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 59.005 CYP27B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50567 PES1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30078 superficial stratum of r8BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02707 SSH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30168 SCGB3A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72848 rhombomere 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.84258 LRRC58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91412 GTEX-WH7G-0005-SM-3NMBX GTEx Tissue Sample Gene Expression Profiles 1.0 1.17732 COQ9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43007 E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NUGC-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.45759 GTEX-QVUS-0226-SM-3GIJY GTEx Tissue Sample Gene Expression Profiles 1.0 0.968817 SPAG7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05491 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null DBTRG05MG CCLE Cell Line Gene Expression Profiles -1.0 -1.63051 SEMA4D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34241 GTEX-TSE9-2626-SM-4DXV2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.998082 EP300_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMD1-0011-R5A-SM-4AT47 GTEx Tissue Sample Gene Expression Profiles 1.0 1.9764 GTEX-SUCS-0006-SM-4DM59 GTEx Tissue Sample Gene Expression Profiles 1.0 1.40493 GTEX-NPJ7-0008-SM-4E3JS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.860964 GTEX-NL4W-0011-R4a-SM-2I5GZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07739 IRAK4_Deficiency_GDS2641_653_mouse_Embryonic fibroblasts GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null central layers of TG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.68308 Bed nuclei of the stria terminalis, anterior division, magnocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33492 Lung disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.732 NELFE_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDAMB157 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.39837 OKAJIMA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.01669 KDM4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.37368 15656903-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null GSE199899_4_v_2_diethylnitrosamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null SCRT2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.9367 H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null SNU-C5 COSMIC Cell Line Gene Mutation Profiles 1.0 null AMZ2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23319 laterodorsal subdivision of area 8 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19363 OUMS23 CCLE Cell Line Gene Expression Profiles 1.0 2.00203 gallbladder HPA Tissue Protein Expression Profiles 1.0 0.711602 GTEX-X4XY-0008-SM-46MVL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13536 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6955-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SPACA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04052 496100507_FWM_dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.66917 GTEX-XBED-0008-SM-47JWO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.931649 H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BT549 DepMap CRISPR Gene Dependency 1.0 3.01161 r5 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16407 CERS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20788 TMEM87A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54673 SUDHL5 DepMap CRISPR Gene Dependency 1.0 2.21739 PK-45P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.56723 preisthmic midbrain tectum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.96776 GTEX-Q2AG-0011-R3A-SM-2HMJ9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29593 Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.061 NARF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29315 Medial pretectal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16589 DHX30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00049 TF1 CCLE Cell Line Gene CNV Profiles 1.0 1.75055 GI-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K27ac_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null IFNAR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30471 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PSDG-0008-SM-48TE5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71607 Cortical surface area (MOSTest) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.769897 CTCF ENCODE Transcription Factor Targets 1.0 null H3K9ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lobule II, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47861 AR-21915096-LNCAP-1F5-HUMAN ChEA Transcription Factor Targets 2022 1.0 null paraventricular nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.28332 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RR-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3472-01A-01R-1193-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PX3G-0008-SM-48U2L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25098 GTEX-T5JC-0008-SM-4DM6A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56589 SH2D3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04174 SRY ChEA Transcription Factor Targets 1.0 null ID1_01_118 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59965 dorsolateral part of m2A Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.81904 ALKBH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.60795 primary auditory cortex (core)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.926625 ZBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94666 H3K4me1_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PKN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83714 STRIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.03989 POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF500 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88737 MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.860572 WHSC1 ENCODE Transcription Factor Targets 1.0 null MFE280 CCLE Cell Line Gene Expression Profiles -1.0 -1.61592 SLFN13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71959 GEMIN8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39549 Mesothelioma_MESO_TCGA-LK-A4O6-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null KDM5A ChEA Transcription Factor Targets 1.0 null ES-I3 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.41672 superficial stratum of Hb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11122 superficial stratum of PcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54646 Lung adenocarcinoma_LUAD_TCGA-38-A44F-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.38929 Medial habenula Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.189 HSC-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null OVTOKO COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-RN64-1226-SM-2TC6E GTEx Tissue Sample Gene Expression Profiles 1.0 1.32331 EED CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41254 MT-ND2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.20324 ZNF79 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96694 GTEX-NFK9-0008-SM-4E3JE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14847 globus pallidus, internal segment, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.30159 r5 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16407 MAPK15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65099 Lung adenocarcinoma_LUAD_TCGA-55-8512-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NEUROD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01735 EMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05884 GTEX-WFG8-2426-SM-3GILL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.894077 GTEX-W5X1-0008-SM-4LMKA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25519 seminal vesicle HPA Tissue Protein Expression Profiles 1.0 0.711602 AR-35650195-DSRCT-HUMAN-MESENCHYMAL-SARCOMA ChEA Transcription Factor Targets 2022 1.0 null WSU-NHL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.903146 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 RINT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90885 Bed nuclei of the stria terminalis, posterior division, interfascicular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05589 IZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.73575 ARVCF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.97977 RRS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26082 PMC12464728-HSR2-8-e71283-s008.pdf-357-FOS_FOS Rummagene Transcription Factor Associations 2026 1.0 null Sarcoma_SARC_TCGA-3B-A9HP-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IRF2BPL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09493 GTEX-QDVJ-0926-SM-2I5FU GTEx Tissue Sample Gene Expression Profiles 1.0 1.82499 GTEX-PVOW-2526-SM-2XCF7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34837 GTEX-WHWD-0005-SM-3LK7D GTEx Tissue Sample Gene Expression Profiles 1.0 1.01426 GSE196117_1_v_11_clarithromycin_human RummaGEO Drug Perturbation Signatures 1.0 null SGF29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41212 SRC-2_KO_GDS5087_485_mouse_Heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null CCDC50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51726 Lung adenocarcinoma_LUAD_TCGA-55-6986-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H2052 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.915874 posteroventral (inferior) parietal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.67302 PCYOX1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83569 DETROIT 562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03612 BTBD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70752 COR-L47 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.97389 POLR2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null U-2 OS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.959701 ZNF75D JASPAR Predicted Human Transcription Factor Targets 2025 1.0 70.8522 SNU-407 COSMIC Cell Line Gene Mutation Profiles 1.0 null NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.58345 GTEX-PVOW-0008-SM-48TE8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36379 PMC11932929-41388_2024_3264_MOESM4_ESM.xlsx-p_0_05_FC_0_5_n_675-Differentially_expressed_genes_in_MCF7_AR-isolated_BCSCs_after_4_days_GSK591_500nM_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XXEK-0008-SM-4BRW7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.935812 nucleus LOCATE Curated Protein Localization Annotations 1.0 null NCI-H2081 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.904465 Hepatomegaly CTD Gene-Disease Associations 1.0 1.10769 Medulla Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.99307 MON DepMap CRISPR Gene Dependency 1.0 2.12399 GTEX-X62O-0005-SM-46MV1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.42737 Lung adenocarcinoma_LUAD_TCGA-55-6978-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CNTROB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44938 NCI-H2126 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.49105 GTEX-N7MS-0011-R6a-SM-2HMJ4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02454 POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DISP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28511 H3K9me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null SOX9 ChEA Transcription Factor Targets 1.0 null NCIH1105 CCLE Cell Line Gene Expression Profiles -1.0 -1.76512 MDST8 CCLE Cell Line Gene Expression Profiles -1.0 -1.8025 tonsil_8a1 HPA Tissue Sample Gene Expression Profiles -1.0 -0.972695 GTEX-TSE9-0011-R1A-SM-3DB7E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.866127 Brain morphology (MOSTest) GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.2699 GTEX-OIZH-1826-SM-2YUNP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03356 GSE158431_2_v_3_pioglitazone_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-QVUS-0008-SM-447AY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46688 GSE162892_4_v_0_sox9_human RummaGEO Gene Perturbation Signatures 1.0 null GSE202434,GSE202438_7_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.05892 mediodorsal nucleus of thalamus_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.62242 IGR39 CCLE Cell Line Gene Expression Profiles -1.0 -1.63282 GTEX-XAJ8-1126-SM-47JYA GTEx Tissue Sample Gene Expression Profiles 1.0 1.0533 GSE172295_0_v_2_sh3gl1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE196117_6_v_11_clarithromycin_human RummaGEO Drug Perturbation Signatures 1.0 null HOPX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89516 middle frontal gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.934122 POLR2AphosphoS2_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VUSH-0008-SM-47JWK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04663 SLC35B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43157 SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03612 primary auditory cortex (core)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.877988 JIMT-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.85853 ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T2YK-0005-SM-32QOV GTEx Tissue Sample Gene Expression Profiles 1.0 1.42116 ETV3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90449 NCI-H1437 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.915874 posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.35645 GTEX-X5EB-0008-SM-46MU3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25713 CTCF_MEL cell line_mm9_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCO2 DepMap CRISPR Gene Dependency 1.0 2.02493 PNPLA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9134 GTEX-S4P3-0226-SM-3K2BD GTEx Tissue Sample Gene Expression Profiles 1.0 0.975547 MDK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86016 POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QCQG-0008-SM-48U2G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04973 GTEX-XLM4-0008-SM-4AT4W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55485 GSE224969,GSE224971_0_v_5_chtop_mouse RummaGEO Gene Perturbation Signatures 1.0 null TMEM245 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.85766 GSE168401_1_v_3_harmine_human RummaGEO Drug Perturbation Signatures 1.0 null DPF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68674 DDX11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45373 PHF8-20622853-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-N7MS-0011-R3a-SM-33HC6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26006 gracile nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.967991 KG1C CCLE Cell Line Gene Expression Profiles -1.0 -1.92092 chr1_45696611_C_T_b38 GTEx eQTL 2025 1.0 1.00993 GSE112174_5_v_7_runx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null KNS-42 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4FC-06A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEP120 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65086 Perturb_3081_KO_Dock11_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.0176 H3K4me1_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF700 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.12127 KDM5A ENCODE Transcription Factor Targets 1.0 null GTEX-P4PQ-0008-SM-48TDX GTEx Tissue Sample Gene Expression Profiles -1.0 -2.33199 PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-a-Classification_of_camel_SON_basal_genes_-_transcription_factors_SON Rummagene Transcription Factor Associations 2026 1.0 null Serous carcinoma_Fallopian tube_GSE10971 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.55071 LIFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15994 MINDY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.09419 GTEX-OXRO-0006-SM-2I5EM GTEx Tissue Sample Gene Expression Profiles 1.0 0.891223 FBXL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.04517 GTEX-P4QS-0526-SM-2I3ET GTEx Tissue Sample Gene Expression Profiles 1.0 1.66829 GSE221577_1_v_5_pik3r1_human RummaGEO Gene Perturbation Signatures -1.0 null Bed nuclei of the stria terminalis, anterior division, fusiform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36312 NUP205 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59674 Lobule II, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.58887 HS819T CCLE Cell Line Gene Expression Profiles -1.0 -1.45131 GSE128054_1_v_0_myt1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-Q2AG-0011-R6A-SM-2HML7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.848527 NR2F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.8317 MDA-MB-175-VII Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.89601 posterolateral cortical amygdaloid area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15429 COL16A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72263 SUM 1315M02 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.53822 RAB31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38796 KMT2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96041 GTEX-XUYS-0008-SM-47JYZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.84766 DTX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02021 PMC5989213-41467_2018_4462_MOESM8_ESM.xlsx-3-Supplementary_Data_3_List_of_2687_genes_differentially_expressed_between_SETBP1-G870S_and_Empty_293_FLP-In_lines_SETBP1 Rummagene Transcription Factor Associations 2026 1.0 null corpus callosum Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.70389 Six4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.1697 GTEX-VUSG-0008-SM-4KL24 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17813 TXNRD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57442 amygdaloid complex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.5795 MAP3K3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22324 GSE196117_1_v_8_clarithromycin_human RummaGEO Drug Perturbation Signatures 1.0 null JUND_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRY-22984422-TESTIS-RAT ChEA Transcription Factor Binding Site Profiles 1.0 null SUB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43833 TXNDC16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9638 GTEX-XUW1-1026-SM-4BONY GTEx Tissue Sample Gene Expression Profiles 1.0 0.904347 GTEX-TKQ1-0008-SM-4DXSO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90837 KMS12BM CCLE Cell Line Gene CNV Profiles -1.0 -1.39495 CDX2-21074721-CACO-2-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-OOBK-0008-SM-3NB27 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50981 SEC31B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.25044 GSE153662,GSE153664_1_v_0_zeb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null UACC-893 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.933701 PANC 05.04 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.86414 PMC7914369-thnov11p3676s2.xls-BPTF-KOvsCtrl-AccID_BPTF Rummagene Transcription Factor Associations 2026 1.0 null basolateral nucleus (basal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12816 CFPAC1 CCLE Cell Line Gene Expression Profiles 1.0 1.58456 GTEX-T2IS-0008-SM-4DM75 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.941028 ZNF420 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.4021 KPNYN CCLE Cell Line Gene Expression Profiles -1.0 -1.85568 GTEX-N7MT-0726-SM-3TW8S GTEx Tissue Sample Gene Expression Profiles 1.0 1.19483 GTEX-U412-2026-SM-4DXSI GTEx Tissue Sample Gene Expression Profiles 1.0 0.953594 FAM20C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87551 amygdalohippocampal transition zone, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.979933 layer 1 of PrS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0996 primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.55693 928 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.7952 RCN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4331 RAD21_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FBXL15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88016 GTEX-WY7C-0006-SM-3NB3L GTEx Tissue Sample Gene Expression Profiles 1.0 0.833979 hippocampus (hippocampal formation)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.976671 RAD21 ENCODE Transcription Factor Targets 1.0 null CAD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77648 POLR2AphosphoS2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VPS11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54107 SLC35A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49488 Hnf1a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.0464 H3K27ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null XRCC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12926 CLNS1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.08206 posteroventral (inferior) parietal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.00089 TMEM167B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50386 CASD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29688 GSE154074_5_v_0_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null KC-48-OO62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.261972 intermediate stratum of r9Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11622 NCI-H2170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.869827 GPR150 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60993 CHMP1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77188 deep layers of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.854575 PELI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72011 GSE160817_4_v_1_slamf6_human RummaGEO Gene Perturbation Signatures -1.0 null r10 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1812 central medullary reticular group, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.834252 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4351-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Fatty Liver CTD Gene-Disease Associations 1.0 1.07234 GTEX-RWS6-0005-SM-2XCAN GTEx Tissue Sample Gene Expression Profiles 1.0 1.41289 PMC7681055-ACEL-19-e13226-s014.xlsx-Sheet1-Ryk-independent_FOXO3_targets_FOXO3 Rummagene Transcription Factor Associations 2026 1.0 null CHFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.35015 superficial layers of TG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.79312 KCNMB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53731 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4143-01A-01R-1188-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LRP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2312 GATB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72717 TDRD12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98016 CSNK2A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12549 ACOX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26849 NB17 DepMap CRISPR Gene Dependency 1.0 2.29438 GSE203158_0_v_14_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null intermediate stratum of THyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24484 GTEX-Q2AH-0426-SM-2I3EP GTEx Tissue Sample Gene Expression Profiles 1.0 1.69179 GARRE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81802 GTEX-P4QT-0008-SM-48TDZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01046 KDM6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73208 temporal pole, right, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.842644 SLC35F2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6209 amygdaloid complex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.49355 lateral IC periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.99256 HAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45103 PRPSAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4474 anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.849137 BICR 22 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.29661 LAMC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.80717