association	dataset	threshold value	standardized value
GSE216273,GSE216292_14_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETV5::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.6108
Hand1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	42.9868
DA-35-DU85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289163
GSE156115_2_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Atoh1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.935
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_12_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Jun	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.6767
GA-04-JM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.320497
Thyroid cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.193
Irf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	47.8953
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.0
HIR complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.365
Tcf21	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.5525
GSE144838_1_v_5_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.36
Rarb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	72.9299
ARMCX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0186
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261944
Foxj3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.5153
FF-86-NH56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252387
HA-22-CY42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.296959
GSE155836,GSE155839_3_v_2_alvocidib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GLTP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35659
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4258
EHMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92291
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE165704_0_v_1_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5286
Hoxa13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	45.9862
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AP1S2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95469
GSE240896,GSE240899_2_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233647_4_v_6_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAZ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	85.4691
SH2D5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6301
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.5303
PMC11067031-pnas.2317690121.sd05.xlsx-Sheet1-Differentially_expressed_genes_between_PML_RARA_GFP_vs_Empty_vector_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
MAPK9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63748
FD-29-MM50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2136
GSE161825_1_v_0_tipranavir_human	RummaGEO Drug Perturbation Signatures	1.0	null
Retinal cone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.722
DC-23-UM36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265441
Laryngeal cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.14
DA-40-HO94_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281934
GSE240896,GSE240899_10_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135352_2_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE217452_2_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232605
FAM193A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1702
GSE71674,GSE71676_0_v_2_cbfa2t2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	63.3672
GSE162892_3_v_2_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.1299
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pyruvate decarboxylase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.276
Hyperphosphatemic familial tumoral calcinosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.944
Sox1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.0068
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297613
VA-48-RJ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243733
ETV2::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.162
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-C_FUS-DDIT3-eGFP_vs_eGFP-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNX12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86638
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27606
GSE162892_3_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF816	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.0199
PMC10042887-41419_2023_5742_MOESM4_ESM.xlsx-Table_S4-Table_S4_Overlap_genes_of_HOXB3_vs_HOXB3-_and_APC-KO_vs_APC-intact_HOXB3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE109285_3_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Masseter	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.79
GSE149442_1_v_0_gdpd3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NR1D1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.7977
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151612_0_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.2595
NOL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.9248
GSE146074_9_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226584,GSE226589_2_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3888
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210989
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	167.535
PMC8387919-mmc2.xlsx-ST6_NEUROG3-KO_downreg-Supplemental_Table_6_Genes_downregulated_in_NEUROG3-_-_hESC_line_differentiated_to_pancreatic_endocrine_progenitors_d13_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bach1::Mafk	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.1842
GSE216273,GSE216292_0_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.606
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
Male infertility due to acephalic spermatozoa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.617
GSE114992,GSE114993_4_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Photoreceptor disc membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.167
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_1h-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF257	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.0152
GSE223008_7_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nucleolus organizer region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.214
NOP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43024
GSE223893_2_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE187006_0_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF93	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	153.9
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254566
GSE183994_1_v_0_scml2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
APP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63123
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.023
Tooth bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.99
GSE185519_1_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.4352
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	85.3667
Nfe2l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.051
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-D_eGFP_vs_WT-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3852
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230507
DCTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02584
PMC12784616-12711_2025_1028_MOESM2_ESM.xlsx-TableS5-Table_S5_Summary_of_significant_MR_associations_in_blood_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6765
GSE158975_0_v_1_spp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD	Rummagene Transcription Factor Associations 2026	1.0	null
NHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.4526
GSE158320,GSE183351_2_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE218580_1_v_0_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_13_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
Cervical spine	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.732
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	102.267
PRPF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29125
GSE199606_6_v_7_csf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3118
INSM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	85.2917
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200305
GSE144919,GSE145177_1_v_0_dazl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
EC-82-LV30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238226
ZNF454	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	136.951
EIF4H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66148
Spermatogenic failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.87
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NDUFA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01001
UBE2G2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88604
GSE199606_6_v_7_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE143782_3_v_4_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.5334
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217605
GSE131649_6_v_10_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
22q11 2 copy number variation syndrome	WikiPathways Pathways 2024	1.0	null
ASCL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.7187
GSE65617_5_v_3_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244499
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE164874_5_v_11_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	211.478
GSE233647_4_v_5_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
SP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	317.61
GSE206342_1_v_0_kpna2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237203
Moderate to vigorous physical activity levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.869897
Photoreceptor outer segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.258
ZNF213	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	88.8574
GSE223893_11_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.023
GSE206226_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Holoprosencephaly 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.604
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.214
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.8986
Female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.023
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215383
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	321.152
Rod photoreceptor outer segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.439
TD-40-ZR64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227837
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.8333
GSE169152_3_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135352_0_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.1898
ZNF669	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50924
PANO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81654
PLEKHO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92628
KHDRBS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41066
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206115
BA-84-TD72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230149
GSE195663_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8647
KLF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	167.844
Enamel epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.775
SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.798
Hoxd13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.5851
GSE153064,GSE153065_1_v_2_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCFL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3449
Pparg::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	41.1438
GSE102505_5_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219146
Solitary median maxillary central incisor	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.521
IER3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59951
GSE171837_3_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PSMC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10003
GSE115542_5_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE131649_6_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Testis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.023
FEZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.9321
GSE100732,GSE100733_0_v_1_lrpprc_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11461876-42003_2024_6975_MOESM3_ESM.xlsx-Supplementary_Data_1-Supplementary_Data_1_Differentially_Expressed_Genes_HSE_THP1_Vs_THP1_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3214
ESR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.5339
PDCD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36035
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.8449
Retinitis pigmentosa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
ZNF24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2164
ZBTB12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2805
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218439
GSE195663_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE88819_1_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mafg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.0256
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.2053
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131588,GSE131690_1_v_0_setd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8387919-mmc2.xlsx-ST6_NEUROG3-KO_downreg-Unnamed_4_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
PSMB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07909
GSE126127_5_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Male infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.331
PMC5503627-oncotarget-08-39497-s003.xlsx-hypo_in_shUHRF1_KD-Unnamed_7_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PRDM9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	285.608
GSE242083,GSE242098_3_v_4_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	315.242
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.9183
FC-20-EQ58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248547
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5719
GSE233679_14_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97466
GSE190316,GSE190324_0_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE237426_0_v_1_eif4a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAX::MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2857
ARPE-19 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.84
PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226584,GSE226589_3_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Auditory vesicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.733
DDX27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76455
GSE188458_2_v_0_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.7793
ZNF708	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.1213
ZFYVE27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62777
KLF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	232.744
Male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.023
SP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	237.372
SAP30BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33334
PMC9894241-pnas.2211429119.sd05.xlsx-G3_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
SLC25A34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84461
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285889
ZNF320	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	440.409
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
AA-62-HP31_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223271
Tfcp2l1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.0637
GSE213588_9_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Stat2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	61.2349
GSE233679_5_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PATZ1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	392.898
UPF3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86941
GSE247764_5_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE245778_1_v_0_runx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9894241-pnas.2211429119.sd05.xlsx-G6_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142210_11_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223893_11_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Calcinosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.292
TCF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.9458
GSE128730_4_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nucleolar chromatin	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.071
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.4743
NFKB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.4091
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.0766
MAGEB17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42601
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.1961
PYM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02779
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE121824,GSE121826_0_v_2_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
COPS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15546
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.3879
KLF14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	193.887
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.475428
AB-97-BI36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28106
Cauda epididymis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.458
EBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.7514
ZNF549	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.1568
SNAI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.8167
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.1132
GSE233679_5_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE233679_14_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.430528
TCF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.3859
GNG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03775
GSE142210_3_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148657_2_v_1_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
ORMDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43218
GSE216273,GSE216292_14_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lhx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.4
GSE190316,GSE190324_0_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.432994
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209947
KLF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	240.377
NR6A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9562
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE152734,GSE152735_2_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HC-76-SY22_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269688
Sperm head	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.396
GSE158743_1_v_2_nfkbia_human	RummaGEO Gene Perturbation Signatures	1.0	null
RRP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32243
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202408
Male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.023
ZNF530	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	181.083
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Gene_Name_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE101336_1_v_3_decitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21647
CD-35-BD44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219066
GSE179880_10_v_3_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF281	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	428.024
Pax7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.5608
GCM2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1936
CA-90-RU33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251995
Pharyngeal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.982
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
THAP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.8291
KLC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85579
ZNF707	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.9404
GSE216273,GSE216292_14_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE153871_5_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Spermatogenic failure 16	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.621
GSE187006_3_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.6314
PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-DMOG_-_HIF1A-gene_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE114992,GSE114993_1_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.023
Urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.023
ZNF574	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.6624
GSE223008_7_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HC-01-FD24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300314
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PLAG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	155.778
Mecom	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.9259
chr22_20152711_G_GC_b38	GTEx eQTL 2025	1.0	1.23961
SELENBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2134
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217758
DCAF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02689
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23747
Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	43.6175
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.192
GSE101239_3_v_2_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.023
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1578
GSE153064,GSE153065_1_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Photoreceptor cell cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.135