association	dataset	threshold value	standardized value
Darunavir	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
Perturb_257_KD_KLF6_SRP150445	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.49917
GSE111247_2_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100603_PCx_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.30028
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36017
GSE149870_0_v_1_pfn1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
U2AF1L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68316
A549_Luminespib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118436
A 438079	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
Perturb_15824_KO_Ttc8_SRP247589	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.73163
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08077
thyroid gland	HPA Tissue Gene Expression Profiles	1.0	1.16481
VMRCLCD	CCLE Cell Line Gene CNV Profiles	1.0	1.59943
fallopiantube_8c	HPA Tissue Sample Gene Expression Profiles	1.0	1.3699
Perturb_3573_KD_JAB1_SRP222371	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Perturb_13020_KO_ALOX5_SRP367905	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
adrenal_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.5973
MLN 8237	DeepCoverMOA Drug Mechanisms of Action	1.0	0.48
Perturb_14321_KD_CD95L_SRP111532	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.5963
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.40391
MCF7_SB431542_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136386
GW 3965	DeepCoverMOA Drug Mechanisms of Action	1.0	0.23
GSE80446_0_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SA-32-CC58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305425
ZNF253	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75306
EB2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.900502
GSE189772,GSE189773_3_v_2_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_14374_KD_SRF_SRP150935	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.8507
Perturb_13336_KD_Pou2f1_SRP149831	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.37106
Perturb_9064_KD_POU5F1_SRP100928	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-19.301
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.9457
2988_FBL_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04876
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.32403
4107_IMP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.691132
7726_SDHB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.522681
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-3.81858
COR-L321	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.09546
K562_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160486
SF539	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.77015
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248951
GSE242333_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_9062_KD_POU5F1_SRP100928	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_7506_OE_ADARB1/STRBP_SRP195616	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.01126
GSE86507,GSE86509_7_v_2_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE136869_1_v_0_lpar2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE62843,GSE64371_2_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE93309_2_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.2807
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.7278
GSE195559_6_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04093
Perturb_14203_KD_ERBB2_ERP118856	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-18.4685
PRPF19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89229
HOXD9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5921
Perturb_532_KD_TCF4_SRP234742	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.0068
GSE184902_4_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168873
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.94975
Perturb_8275_KD_SF3A3_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.0873
Perturb_9289_OE_KRAS_SRP172671	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.50068
ESR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2626
A549_Tucidinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125963
Perturb_15661_KD_Hnrnpc_SRP313287	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.26666
A549_IOX2_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140949
Perturb_2906_OE_MACROH2A2_SRP333362	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.05304
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.426715
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.558842
BCL2L10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77533
GSE75976_3_v_4_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COLO320	CCLE Cell Line Gene CNV Profiles	1.0	1.95078
GSE209898,GSE209899_0_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cerebellar cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.36802
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16387
PMC8143797-elife-62857-fig3-data2.xlsx-DEgenes_SW872_TAZ-CAMTA1_vs_EV-Gene_CAMTA1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-SOX4_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_6624_KD_DDX5_SRP237546	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.17721
KHNYN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13798
NFATC3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1149
PMC8212786-DataSheet_4.xlsx-CESC-ZBED3_ZBED3	Rummagene Transcription Factor Associations 2026	1.0	null
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.91308
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.696171
G142	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.29331
PMC6858560-NIHMS1538530-supplement-Supplementary_Tables.xlsx-Supplementary_Table_22-Supplementary_Table_22_Aberrant_Splicing_Events_in_TET2_SRSF2_co-mutated_AML_Patients_from_the_Beat-AML_cohort_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11131
A549_UNC1999_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142765
A549_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150089
GSE135352_0_v_1_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2132_DDX56_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.654528
SOX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9859
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_8729_KD_USP7_SRP256243	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.55185
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.36228
Cco	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.687
GSE111385_2_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_MK-5108_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160095
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.51339
BICR56	CCLE Cell Line Gene CNV Profiles	-1.0	-1.9452
HS 766T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.8797
ESRRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4882
posteroventral (inferior) parietal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.938074
Perturb_8086_KD_EIF4G1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.59935
GSE140651,GSE140653_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149366_1_v_0_sulconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_13953_OE_lncNR2F1_SRP179994	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.59851
GSE132694,GSE132717_0_v_2_meis1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Quetiapine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
Perturb_10097_KD_CNOT8_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.84946
AFF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13166
GSE242083,GSE242098_3_v_4_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SHOX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1479
MCF7_Ki8751_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159945
Perturb_7750_KD_POP1_SRP155278	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.53001
CEP152	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1692
posteroventral (inferior) parietal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0141
GSE226584,GSE226589_1_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE73562,GSE73563_1_v_2_preb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
8050_SLC35E3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.542866
ventrolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.850625
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
G61	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.878704
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.6064
9687_UTP6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0253
LAMA84	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51862
Perturb_4931_OE_KLF17_ERP131959	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.24114
Perturb_1873_KO_Ifnar_SRP371304	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.2503
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240256
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Linifanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137298
Perturb_13579_KD_Fem1b/Keap1_SRP274135	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.86252
Nr1h3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.419
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.972474
Colon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Perturb_449_KO_RPA_SRP158719	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.0009
RGMB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22128
MCF7_Droxinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014486
GSE196117_1_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE198165,GSE198166_6_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.6042
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.35
A549_Alendronate sodium trihydrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182882
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.13173
CPNE9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08876
DNMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85364
7526_RPS4X_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.733615
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.947076
4695_LSM5_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.527116
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.7721
Perturb_9185_OE_ZNF593AS_SRP298754	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.41515
GSE162892_3_v_5_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H2795	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.93291
GSE135350_2_v_7_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
SiHa cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.085
Perturb_14905_KD_LIN41_SRP032743	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.1503
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.65935
PMC7423359-abb8771_Table_S4.xlsx-Sheet1-Genes_detected_at_least_twice_in_h4E_BP1-hyperTRIBE_711_genes_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239578_0_v_4_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166914_1_v_0_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE143782_6_v_5_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06939
GSE199204,GSE211619_4_v_6_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE161800_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
INO80D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16798
DPM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35194
TMP269	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
BC3C	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47479
SMIM19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04323
496100604_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.64719
Perturb_3915_KD_CTNNB1_DRP003300	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.93886
GSE145311_0_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE153871_5_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Respiratory system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.084
MCF7_UNC0379_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120885
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.491127
Perturb_14883_KO_H11_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.29598
DDX51	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06556
M059K	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.28832
A549_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176186
GSE208634_1_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OCI-AML2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.1401
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10864
Perturb_7851_KD_XAB2_SRP193107	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.3551
RKN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06159
Perturb_14890_KO_H15_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.71626
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.74435
GSE213410_0_v_3_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GEMIN8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26132
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE200352_10_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Tbx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.6545
Perturb_9170_KD_CFTR_ERP118933	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.617
ELOA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09818
GSE182770,GSE182784_0_v_1_chd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HSF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.635
A549_Amisulpride_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170726
GSE232631_0_v_2_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A2780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.77077
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_13952_OE_lncNR2F1_SRP179994	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.83634
Pparg::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	42.2201
A549_Aurora A Inhibitor I_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176146
Perturb_313_KO_CARM1_SRP279319	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-19.5229
NCI-H23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41291
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3328
GSE202434,GSE202438_7_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE84148,GSE96938_0_v_2_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.28
Perturb_7652_KD_RRP40_SRP126942	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.5843
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09092
Perturb_1230_KD_HNRNPL_SRP033393	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.31408
Perturb_9335_KO_CDKN2A_SRP158425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.85046
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9894
A549_Azacitidine_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.012305
APOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31184
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.958208
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.954982
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6541
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.96715
496100595_PCx_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02859
Perturb_8984_OE_TFAP2A_SRP367630	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.18329
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.9003
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
prostate_4c	HPA Tissue Sample Gene Expression Profiles	1.0	1.15157
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.830851
Perturb_4020_KO_Atf6_SRP260102	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.38292
PMC12571111-qiaf131_supplementary_data.xlsx-ST2-Supplementary_Table_2_Results_of_the_two-sample_MR_analysis_on_the_causal_role_of_CD4_T_cell_expression_profiles_on_CRC_development_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
MFSD14A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40108
BICR18	CCLE Cell Line Gene CNV Profiles	1.0	1.83447
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE229344_1_v_0_cyb5r3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
J82	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43877
GSE146982_4_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205976,GSE205978_2_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_6620_KO_NEUROD1_SRP388830	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.90353
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE208634_1_v_2_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_9400_KD_MYCN_SRP104120	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.0819
Perturb_7254_KO_MBD1/MBD2/MBD4/MECP2_SRP337936	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.41888
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE130246_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7515_RPS26_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.537158
GSE226249_5_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193258,GSE193259_9_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5022
GSE221577_3_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Ileocecum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.025
MCF7_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140565
Perturb_12160_OE_TCF7_SRP144189	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.72678
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.425176
AB-21-VE32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.437289
ATF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1364
Perturb_2744_KD_MUC1_SRP214243	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.75496
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_13921_KO_PPARGC1A_SRP314654	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.49605
ISCU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38008
GATA3-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Rectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29924
HJC0350	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.24
METRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19666
Perturb_4852_KD_ZNF503_SRP059197	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.43393
CH25H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03123
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0204
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.87617
GSE196110_1_v_2_ndrg3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_3766_KD_lincDUSP_SRP111736	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.44525
CALM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18672
Mitochondrial small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.702
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.59764
SNU324	CCLE Cell Line Gene CNV Profiles	-1.0	-1.80987
PMC10901781-41467_2024_46134_MOESM12_ESM.xlsx-Supplementary_Data_9-Supplementary_Data_09_Differential_expressed_genes_in_RUNX1-mutated_AML_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_9411_KD_Pcbp1_SRP251371	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.00252
GSE181517_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.32543
GSE111247_2_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41493
Lung	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.084
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE187006_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.958208
TF-77-DW08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.375747
Perturb_5395_KD_LIM1_SRP402415	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.21616
GSE189683_1_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41291
7508_RPS19BP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.637487
nb4	HPA Cell Line Gene Expression Profiles	1.0	1.17659
EIF2B4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66569
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112761,GSE112767_2_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.977575
Perturb_7242_KD_CNOT1_SRP285534	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.21631
GSE135352_2_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE221577_1_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11227377-2506586.f2.pdf-16-ZNF585A_ZNF585A	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_2576_KD_LINE1_ERP011233	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.91601
GSE239844_11_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SOX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9451
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-PBX3_PBX3	Rummagene Transcription Factor Associations 2026	1.0	null
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04626
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Alisertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176277
Perturb_2715_KO_TET1_SRP110516	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.0746
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.44673
A549_Fluorouracil_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128395
Perturb_13016_KO_ALOX5_SRP367905	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
FOXE1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	123.566
GSE213410_2_v_3_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193993_4_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_9941_KD_MBNL1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.89032
Vermiform appendix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.025
GSE206226_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
IQGAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28842
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.70342
Artery - Aorta	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.951668
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4573
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
CCNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30732
Perturb_6871_KD_HHEX_SRP323378	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.82614
GSE84148,GSE96938_3_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_7507_OE_ADARB1_SRP195616	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.47586
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263777
11152_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.502736
NCI-H460	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.851545
PPARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.3628
FUT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24808
7478_RPL7L1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.53093
OCI-AML5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.1808
Perturb_8223_KD_CKAP4_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.37634
GSE111385_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.4822
GSE198165,GSE198166_8_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.62145
SNU119	CCLE Cell Line Gene CNV Profiles	1.0	1.81971
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.279541
7648_SAP18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.551481
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221905
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.937564
Perturb_4908_OE_SNCA_ERP129142	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35319
HOXB7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8182
HNF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.9973
C17orf49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.368
GSE94849_1_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_11692_KD|OE_SF3A3|MYC_SRP253943	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	19.2218
A549_MLN8054_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165168
Mitochondrial respiratory chain complex I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.683
GSE173232_1_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GD-46-OD81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.343949
A549_Iniparib_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141967
OCIAML2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.9203
NTHL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71818
Perturb_9817_KD_E2A_SRP103740	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.06684
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.72342
Perturb_9821_KD_MYB_SRP103740	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.1477
Organellar small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.701
A549_GSK1070916_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00955445
Perturb_338_OE_PBX1_SRP389513	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.65711
TOR1AIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26209
RORB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1299
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09545
GSE205963_0_v_1_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7431_RPL10A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.579045
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.900803
Perturb_14938_KD_Ptbp1_SRP053095	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.17663
7657_SARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.620364
GSE226249_2_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SHOC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41875
GSE182921_0_v_1_slit2_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24765
Guanethidine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.18
BEC	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE187005_5_v_2_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_10099_KD_HNRNPU_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.20175
A549_XAV-939_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178023
PMC11976845-pr4c00864_si_003.xlsx-Data_S2E_HeLa_LF-Unnamed_4_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.13457
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06293
GSE164508_1_v_0_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FGFR3_KD_GSE41035_77_human_RT112	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE207611,GSE207612_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2613
PMC12499388-ADVS-12-e01774-s002.xlsx-Table_S1-Table_S1_Differentially_Expressed_Genes_between_wild-type_and_TET3-knockout_PANC-1_cells_TET3	Rummagene Transcription Factor Associations 2026	1.0	null
M6PR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07746
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.3089
GSE231641_0_v_1_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.39379
Perturb_2326_KD_SF3B3_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.96453
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.832841
Perturb_311_KO_CARM1_SRP279319	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
2114_DDX27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.542446
A549_Danusertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0109328
Marimastat	DeepCoverMOA Drug Mechanisms of Action	1.0	0.44
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9798
BD-96-HO33_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.549839
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.32684
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.831776
OF-47-EQ74_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217859
MTHFD1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45402
NCI-H1623	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.5553
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.565621
Perturb_7694_KD_SNRNP200_SRP364705	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-18.6383
L1236	CCLE Cell Line Gene CNV Profiles	1.0	2.00401
K562_Ramelteon_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156237
Perturb_2331_KD_SNRPB_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.43631
GSE173307,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_15477_OE_MYC_SRP218384	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.32215
Perturb_16796_OE_CELF1_SRP268416	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.30822
SIG-M5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.997321
Perturb_625_KD_IGF2BP3_SRP068523	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.39192
GSE99687_0_v_1_smad5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_7621_KD_UPF1LL_SRP295982	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.87057
Perturb_7474_KD_Chtopl_SRP144331	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.4956
FGD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10798
8665_TAF5L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.684923
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-mouse_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ZBTB12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.085
Perturb_7623_KD_UPF1LL_SRP295982	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.17955
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.394756
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.35077
GSE210101,GSE210114_6_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brain - Anterior cingulate cortex (BA24)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.50599
GSE183335,GSE183351_3_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Droxinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171971
SLC24A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53108
GSE112860_9_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236296
Perturb_12362_KD_SNRPB_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.04403
GSE119345_0_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	1.0	null
7453_RPL26_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.567968
ZNF680	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1759
GSE224131_3_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_4988_KO_Ythdc1_SRP212677	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.8346
GSE206729_3_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154577_13_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
2791_EXOSC4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.805392
7466_RPL36_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.541435
HOXC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05312
LY334370	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.36
GSE172295_3_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CSRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36853
MDAMB415	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67697
GSE218907_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE165704_0_v_1_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7523_RPS3A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.512012
SW 1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.7079
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.371504
SISO	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.03808
TOV-21G	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.88462
BE-27-RQ61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.430777
PMC9950457-mmc3.xlsx-GRHL2_overexpression_DOWN-gene_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
Actinonin	DeepCoverMOA Drug Mechanisms of Action	1.0	0.41
Perturb_12351_KD_DDX3X_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.51267
GSE230744,GSE237803_5_v_3_hira_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE247084,GSE247087_0_v_1_cdyl_human	RummaGEO Gene Perturbation Signatures	1.0	null
ATOH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20845
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24765
Perturb_12295_OE_PHGDH_SRP363494	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.93755
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1518
GSE147240_0_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5598
Perturb_9412_KD_Pcbp1/Platr18_SRP251371	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.33858
Perturb_17545_KD_EFB1_SRP357509	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.2316
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09179
Perturb_9945_KD_UTP18_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.55681
Perturb_5183_KD_Ssrp1_SRP094584	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
A549_Raltitrexed_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194333
Perturb_13998_OE_MIR1271_SRP256886	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.19206
Perturb_7909_KD_SNRNP200_SRP364705	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.4795
NKX6-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02165
GSE189683_3_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE70935_3_v_5_cyfip1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_13863_KD_TBX2/MYCN_ERP107244	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.0342
K562_Pirarubicin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016478
TAF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11035
4939_MED17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.854562
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241927
FEZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.8038
A549_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144921
HCA-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.16019
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
liver	HPA Tissue Gene Expression Profiles	-1.0	-1.1607
Perturb_12139_KD_PRPF38A_SRP093921	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
TBPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46002
GSE162892_3_v_1_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
CA46	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.46655
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.327716
Perturb_6856_KD_CNOT1_SRP287793	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	19.699
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.876425
TTC9C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11327
7251_RFFL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.735183
ZNF257	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.9227
Perturb_9938_KD_DKC1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.30375
GSE232631_5_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DD-43-WW40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210767
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0229
GSE201657_0_v_1_ash2l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
orbital frontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.957588
RGS11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25166
7527_RPS5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.500046
6024_PABPC1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.545981
Large intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H1623	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.32158
GSE226408_1_v_0_inpp4b_human	RummaGEO Gene Perturbation Signatures	1.0	null
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.594453
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SIRPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31507
GSE221539_1_v_0_lrrc10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_UNC1999_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126481
GSE209898,GSE209899_0_v_1_flcn_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_9886_KD_ABCF1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.71197
MCF7_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132641
ventrolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00351
SU-DHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.795
GSE154577_2_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169743
NR1D1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4238
5900_NUP62_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.717355
BARHL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.1986
GSE133764_2_v_0_chd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF701	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	79.1788
POT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04323
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_7192_OE_DIMT1_SRP267960	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.50826
BT-20	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.22415
A549_Nilotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015328
BAY 57-1293	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
HCC1806	CCLE Cell Line Gene CNV Profiles	1.0	2.42592
PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Unnamed_12_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224553
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30021
SUPT6H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95281
GSE154577_6_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_17440_Mut_Akt_SRP366791	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.63275
CHAF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76821
UT7	CCLE Cell Line Gene CNV Profiles	-1.0	-1.92404
Perturb_2330_KD_SNRPB_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.40472
GSE241701_1_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mo-T	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.70791
Perturb_3481_KO_Ccn1_SRP304010	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.82526
MCM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06332
GSE129186,GSE129223_0_v_1_aicda_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_2337_KD_WBP11_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.60893
Perturb_16953_KO_MLX_SRP183152	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.64658
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-PAX6_UNIQUE_DYS_GENES-NEUN_TLE_vs_TL_log2FoldChange_1_padj_0_1_PAX6	Rummagene Transcription Factor Associations 2026	1.0	null
JURKAT	CCLE Cell Line Gene CNV Profiles	-1.0	-2.38284
DMRTA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0254
GSE133213_6_v_15_znrf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_232_KD_HIF1A_SRP100624	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.47253
Perturb_10365_KD_Setd2_SRP184682	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.22862
CDK2_knockdown_90_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.87329
THAP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9023
Ikzf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.9366
Viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
K562_Selisistat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161809
Vdr	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.6449
SLC38A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22213
Perturb_9358_KO_CDKN2A_SRP158424	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.57074
RARA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.1234
Perturb_4383_KO_PRMT5_SRP149386	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.90649
AD-09-MD49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.514584
Perturb_6482_OE_CD274_SRP125995	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.30901
Perturb_3767_KD_lincDUSP_SRP111736	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.56091
EWSR1-FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	142.61
8157_SMC3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.20317
A549_TMP195_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131696
Perturb_14904_KO_PRMT6_SRP125977	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.11168
Perturb_7235_KD_CNOT1_SRP285534	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.01715
GSE169205_3_v_8_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12347849-mmc1.pdf-22-ENSG00000178764_ZHX2	Rummagene Transcription Factor Associations 2026	1.0	null
GEMIN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43431
496100587_FWM_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.80527
HH	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
GSE102505_5_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
1840_CPSF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.631395
SOX13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6373
esophagus_5c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.859274
2658_EP400_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.568866
Perturb_7541_KO_NSUN6_SRP273753	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.84976
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06939
5735_NOL6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.930047
Perturb_7935_KO_VTRNA1_SRP252980	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.18829
GSE142210_11_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_10011_KD_AARS1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.75162
MCF7_Ki8751_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131545
liver_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.37452
LNCAP	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.859934
Perturb_13254_KD_Ncaph2_SRP073037	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.06432
A549_SRT3025 HCl_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140706
MF-11-EW49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209824
FAM83H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40729
GSE214823,GSE214824_0_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19393
GSE234289_5_v_0_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Roscovitine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170026
PMC11602576-mmc11.xlsx-ST12-Table_S12_Output_of_mash_model_of_milk_and_GTEx_eQTL_effects_Related_to_Figure_2_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_7853_KD_CCNF_SRP212181	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.01037
Perturb_344_OE|KD_SMAD1|GDF6_SRP076553	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE120612_7_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_2370_KD_PRPF8_ERP116477	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.3702
A549_UNC0379_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00862395
NCIH69	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57011
SA-32-CC58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25928
Perturb_14118_KD_RPS6KB2_SRP187713	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.64255
PMC11908325-media-2.xlsx-Table10_MR-Unnamed_6_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.972474
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.581944
GSE86021_1_v_3_crenolanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE215086_8_v_7_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118816_0_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.4216
Perturb_2478_OE_YAP_SRP254362	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.64982
Perturb_13084_KD_Wtap_SRP039402	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.38766
Perturb_7087_KO_Phd2/Phd3_SRP156279	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.97242
A549_BMS-911543_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161461
GSE162892_3_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1895
SOX14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9643
Perturb_15527_OE_CPT1A_SRP292168	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.98857
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217566
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.2908
Perturb_13834_KD_RYK_SRP131789	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.38876
Perturb_93_KD_ANXA4_SRP127547	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.20588
MHH-PREB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.14381
Perturb_16849_KO_Hnrnph1_SRP068520	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Perturb_4962_KO_Dot1l_SRP214101	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.64919
PPP6R2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79284
FOSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24061
Perturb_12542_KO_ADAR_SRP194087	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Lymph node	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.142
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.81131
2795_EXOSC8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.514979
7493_RPP40_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.670097
GSE124410_6_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.4783
MCF7_XAV-939_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183256
ZNF582	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.041
GSE120200,GSE127269_1_v_2_asxl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Arid3b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.0809
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.888652
Rimonabant	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
OC-10-FB51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.769942
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BA-90-AA10_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.281822
G-402	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48372
primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.947676
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.3849
GSE196505,GSE196507_1_v_2_kdm2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Barasertib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143323
A549_Anacardic Acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162103
CDK5_knockdown_99_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.6416
GSE148200_4_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Zaltoprofen	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.46
MCF7_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178285
Perturb_20_OE_Smarca5_SRP217699	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.7217
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.93196
GSE178292_0_v_3_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_9_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GB-46-CK08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.474835
5900_NUP62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.592445
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30021
GSE70935_2_v_4_cyfip1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TC-71	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.946748
GSE102870_3_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
5470_NAT10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.674038
GSE180641_0_v_1_zfp503_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_10095_KD_AGO2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.24127
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135352_6_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE191105_2_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112763,GSE112767_0_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_2318_KD_PRPF8_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.54688
GSE113952,GSE113953_1_v_0_chtop_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.10186
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.65556
GSE250534_0_v_3_cabergoline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.70082
Perturb_8434_KD_CCT3_ERP124101	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.54305
Perturb_15044_KD_PTBP1_SRP124244	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-14.7069
heart_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.32264
Perturb_231_KD_HIF1A_SRP100624	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.97476
Perturb_8057_KD_IGF2BP3_SRP094100	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.44817
GSE112761,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-6_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
C2CD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32329
Perturb_3085_KO_Fads1_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.64745
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE196962_2_v_6_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1083
HCC1143	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.984247
PMC4243378-13059_2014_494_MOESM1_ESM.xlsx-S1_6_Gene_sets_CIITA_BIs-B_cells_CIITA_not_RFX5_RFX5	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_8018_KO_PXR_SRP257678	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.609755
U266B1	CCLE Cell Line Gene CNV Profiles	1.0	1.61887
7513_RPS24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.947508
Perturb_15866_KD_BMI1_ERP013870	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.77031
Perturb_5135_KO_Ythdc1_SRP251747	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.8694
Perturb_7505_OE_ADARB1/ILF3_SRP195616	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.94611
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02175
PMC6484770-41388_2018_602_MOESM5_ESM.xlsx-up_P53_vs_con-Unnamed_1_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
A549_TAK-901_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118473
chr2_37238286_T_C_b38	GTEx eQTL 2025	1.0	1.45219
UBE2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33165
SKNDZ	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38279
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_4935_KD_TP53_SRP067400	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
TEDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24315
GSE161800_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.08372
SOX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4211
GSE233049_1_v_3_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DC-49-EJ23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.731471
PMC11908325-media-2.xlsx-Table10_MR-Unnamed_7_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1500	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64686
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.295716
DD-74-PJ26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215563
Perturb_7614_KO_LARP1/LARP1B_SRP201361	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.64513
H2BC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19257
ntera2	HPA Cell Line Gene Expression Profiles	1.0	1.03301
ACBD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28188
GSE186440,GSE186443_2_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Gastrointestinal tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HEP G2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03114
K562_GSK J1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021014
GSE166783_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
SF539	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31367
Perturb_12256_KO_CD274_SRP215305	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.78021
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.60284
GSE221577_2_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE163862_2_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE114992,GSE114993_0_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171837_0_v_3_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE222574_0_v_2_lmna_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_6674_KD_HDAC9_SRP159451	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.8395
Perturb_2763_KD_CBX3_SRP077334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.51259
prostate	HPA Tissue Gene Expression Profiles	1.0	1.00552
ZSCAN23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27165
CAVIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29126
Perturb_1265_KO_Jak1_SRP214595	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.6604
Perturb_6897_KO_TP53/ZNF84_ERP125489	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.77008
GSE228106_3_v_2_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.105
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22078
9971_ZBTB14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.882134
A549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41493
chr2_37197960_G_A_b38	GTEx eQTL 2025	1.0	1.35834
UC-00-QA88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.441898
Perturb_10096_KD_AGO3_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.49968
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
2792_EXOSC5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.81823
STX-0119	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
GSE229344_2_v_0_cyb5r3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
INMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12879
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.29247
NFIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.7498
Perturb_17442_OE|Mut_Tal1|Akt_SRP366791	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.72212
GSE133764_1_v_0_chd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09636
GSE116810_2_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297539
POLR3G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41018
OV7	CCLE Cell Line Gene CNV Profiles	1.0	1.55321
Perturb_1058_KO_ALPG_SRP277076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.23059
NR2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.9601
MCF7_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160108
C15orf40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04425
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_5392_KD_FOXA2_SRP019241	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.36578
Perturb_3514_KD_RNPS1_ERP130704	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.84951
Cardiac muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.236
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.4167
Perturb_15651_OE_Ccnj_DRP008918	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.62818
MCF7_Motesanib Diphosphate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137672
ACSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40367
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.878704
NCI-H1666	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.831776
GSE102870_1_v_2_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226584,GSE226589_3_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
3861_HNRNPC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.514342
GSE193258,GSE193259_2_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_13014_KO_ALOX5_SRP367905	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	18.2218
Perturb_3622_KO_SMARCC2_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.46299
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE86507,GSE86509_7_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_14117_KD_RPS6KB1_SRP187713	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.30783
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-2.05989
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.47378
MKN45	CCLE Cell Line Gene CNV Profiles	-1.0	-1.75558
Perturb_13644_KD_Trim28_SRP126388	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.91068
GSE201877_1_v_0_yap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.95157
Perturb_11140_KO_Myc/Mlxipl_SRP148418	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.32188
Perturb_8848_KD_APC_SRP267478	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.97754
Perturb_452_OE_MYC_SRP171977	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.0222
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.894736
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3571
CARM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31956
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.939951
Cyanuric chloride	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.42
GSE162892_3_v_2_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
amygdaloid complex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.12079
Perturb_9704_KO_GCaMP_SRP067928	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.67511
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.603622
Perturb_9402_KD_MYCN_SRP104120	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.66744
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.451301
mcf7	HPA Cell Line Gene Expression Profiles	-1.0	-1.12702
GSE228106_3_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Resveratrol_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126707
GSE193993_4_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CL-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.5035
5750_NOP58_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.632829
GSE233548_3_v_0_plscr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JURKAT, CLONE E6-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.64477
7466_RPL36_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.529804
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.79463
PF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46348
MAST3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03175
Perturb_12493_KD_ELK3_SRP361792	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_9522_KO_Ift140_SRP131479	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.79066
A549_EED226_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146675
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23349
Perturb_2844_KD_FOXA1_SRP288463	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.25943
A549_FLLL32_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141155
GSE235644_1_v_0_fasn_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6998_R3HDM1_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.503883
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.1135
Perturb_2317_KD_PRPF31_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.44122
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.884582
ESS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88934
GSE233548_2_v_0_plscr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142259
GB-73-QS80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.590949
GSE125862_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE133683_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5989213-41467_2018_4462_MOESM8_ESM.xlsx-3-Supplementary_Data_3_List_of_2687_genes_differentially_expressed_between_SETBP1-G870S_and_Empty_293_FLP-In_lines_SETBP1	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15011
CEBPG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6275
GSE151612_4_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_9361_KO_CDKN2A_SRP158425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.51334
PMC9669639-mmc3.xlsx-NRLonly-degs-207-Single_cell_RNA-seq_differentially_expressed_genes_between_control_versus_USH1B_NRL_cells_NRL	Rummagene Transcription Factor Associations 2026	1.0	null
A549_JNJ-7706621_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124774
Perturb_9406_KD_GATA6AS_SRP279802	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.32472
PMC10967149-12903_2024_4167_MOESM3_ESM.xlsx-LPS_VS_LPS_PDLSC-CM_776-Gene_symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_4911_KD_ATF7IP_SRP156289	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.23506
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.7873
PMC12042558-12885_2025_14205_MOESM1_ESM.xlsx-Sheet1-Supplementary_file_2_Univariate_cox_regression_of_HOXB8-derived_molecules_HOXB8	Rummagene Transcription Factor Associations 2026	1.0	null
adrenal gland	HPA Tissue Gene Expression Profiles	1.0	1.18944
Perturb_3639_KO_BRD3_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.94166
2238_DLD_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.531357
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2961
NCIH2141	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50665
AE-07-IZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217974
Perturb_8997_KO_KDM6A_SRP309312	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.2924
GSE60691_2_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
C8orf33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09921
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01495
dorsolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07551
Perturb_17584_KO_Crb2_ERP016523	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.58887
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00797
CENPP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06173
A549_AT9283_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117861
Perturb_11691_OE_MYC_SRP253943	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Perturb_13372_KD_RPRD1B_SRP362755	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.40834
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.705062
NCI-H2347	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.2596
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.51327
TP63-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_7516_KO_TFAM_SRP213924	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.72904
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.857644
Perturb_13843_KD_Fgfr1_SRP371980	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.4368
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268962
Heart - Left Ventricle	GTEx Tissue Gene Expression Profiles 2023	1.0	2.1901
NCIH2052	CCLE Cell Line Gene CNV Profiles	1.0	2.02756
ZNF749	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11568
GSE248858_4_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12486367-Supplementary_Data2.pdf-426-FOXL1_FOXL1	Rummagene Transcription Factor Associations 2026	1.0	null
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29924
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.749
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.18175
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4834
PMC10248509-Data_Sheet_6.CSV--GSE58294_DE-genes_AND_GSE66724_DE-Genes_AND_GSE22255_DE-Genes_NOT_Autophagy_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.872601
Perturb_9942_KD_NAA15_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.45416
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_6857_KD_CNOT7/CNOT8_SRP287793	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.94857
2792_EXOSC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.581406
Perturb_15783_KO_Plagl1_SRP318611	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.66582
chr2_37211850_G_A_b38	GTEx eQTL 2025	1.0	1.64484
GSE264621_1_v_6_secretin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8412
Brain - Hippocampus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.09616
Perturb_17_OE_Carhsp1_SRP217699	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.58404
LIAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59108
H4	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
GSE171837_0_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.883755
UQCRFS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0049
M059K	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21912
CLASRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19541
GSE211262,GSE211263_0_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FADD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30161
LA-10-VZ79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.327118
UPF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00001
2105_DDX18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.634645
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.621163
OVMANA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.983075
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270919
cerebellar cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.43197
EB-28-HP05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305807
Flp-In-T-REx cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.958
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.65097
Perturb_3418_KO_Satb2_SRP256439	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.70387
Pancreas	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.681743
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.268
Perturb_15021_KD_RelA_SRP078053	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.7386
EPZ-6438	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.25
GSE203131_0_v_1_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277427
Taranabant	DeepCoverMOA Drug Mechanisms of Action	1.0	0.46
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24298
Perturb_4827_KO_Neil1/Neil2/Neil3_SRP193097	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.31862
K562_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155973
LARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09451
5730_NOC3L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.553034
Perturb_12941_KO_UBE2T_SRP312031	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.27003
RORC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5754
GSE112761,GSE112767_2_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE87615_2_v_3_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE143743_0_v_2_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114992,GSE114993_7_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_13859_KD_MYCN_ERP107244	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.81954
STOML1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10189
A549_CUDC-907_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00910905
PK-45P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.18787
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.49787
GSE195559_8_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112761,GSE112767_4_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ARHGEF10L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02729
Perturb_9009_KD_RELA_SRP061289	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.48913
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5493
Perturb_1858_KO_Nrf2_SRP371099	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.34608
6632_PPIL4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.649381
NCIH1623	CCLE Cell Line Gene CNV Profiles	1.0	1.69292
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ISL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.7507
Perturb_13018_KO_ALOX5_SRP367905	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.3962
Alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE167218_1_v_0_hoxd12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POU2F3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0327
Perturb_7367_KD_H2BC21_SRP308810	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.08434
Six3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.078
SKM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.22709
7206_RCL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.759549
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.80626
PGAM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00495
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.601578
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.20713
hippocampus (hippocampal formation)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.939994
Perturb_10026_KD_TRIM56_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.35803
GSE216043_7_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10928104-41419_2024_6576_MOESM4_ESM.xlsx-S14-MYBL2_targets_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
hek293	HPA Cell Line Gene Expression Profiles	1.0	0.87157
GSE157383_3_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
5089_NIFK_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.501638
A549_UNC0379_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179399
FAM83G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12199
Perturb_2327_KD_SF3B3_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.22658
2233_DIS3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.516487
Sumatriptan	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.24
3776_HIST1H4A_ENST00000359907.3	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.813844
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1889
IC-05-AW29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.609207
Perturb_466_KD_ADAR1_SRP253895	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.20005
GSE200352_9_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199606_1_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
G61	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.16157
ventrolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.919293
Perturb_7257_KO_LARP1/LARP1B_SRP201361	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.39663
GSE102870_5_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30015
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06675
TE1	CCLE Cell Line Gene CNV Profiles	1.0	2.47052
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.15987
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6491
Perturb_9061_KD_NANOG_SRP100928	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23977
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15011
TCF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20968
Repaglinide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.968397
SK-N-DZ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.85893
2233_DIS3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.692313
SKP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04298
GSE86507,GSE86509_4_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_3620_KO_SMARCA4_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.79813
Spi1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	47.3072
Perturb_7932_KD_Spt6_SRP132004	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.914
Perturb_14741_OE_ADAR1_SRP250165	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.32695
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HA-82-XO48_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236387
NCIH23	CCLE Cell Line Gene CNV Profiles	1.0	1.65026
K562_Cediranib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187837
DLD-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.954795
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193993_5_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_4_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.73412
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF667	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6925
orbital frontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.932488
HEC-1-A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09461
Perturb_9939_KD_KIF1C_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.62881
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21077
GSE239844_11_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.841532
Perturb_8069_KD_SFPQ_SRP281189	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.38799
Perturb_2231_KO_Irs1_SRP125007	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.70778
A549_Belinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015527
GSE112761,GSE112767_4_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
3677_HEATR1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.717696
Perturb_13358_KD_Irf1_SRP234803	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.48138
GSE209973_1_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Colorectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE193993_1_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148066,GSE157787_2_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_3619_KO_SMARCA4_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.77422
GSE229468,GSE229471_2_v_3_znf587_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178907_0_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	1.0	null
Mecom	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.0
MEF2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51795
1893_CSE1L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.798835
ZNF341	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9676
WSU-NHL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.19661
Perturb_12895_KO_NCOR1_SRP319377	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.68833
GSE117730,GSE117732_0_v_2_apobec2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE191037_0_v_1_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.80132
GSE146982_3_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.543479
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41937
Perturb_7699_KD_SKIIP_SRP155347	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.94559
GSE149124,GSE149128_2_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_12_in_RNA-seq_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
HT	CCLE Cell Line Gene CNV Profiles	-1.0	-2.30581
Perturb_14606_OE_NUSAP1_SRP407652	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.53088
Perturb_4905_KO_NSUN6_SRP233222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.4194
FOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	165.134
Perturb_2308_KD_DHX8_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.85311
FD-20-OG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.430601
LOU-NH91	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.3782
MV-4-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.964443
Ahr::Arnt	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.625
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.07477
MDA-MB-175-VII	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.78981
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.824997
K562_Celecoxib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164574
GSE155305_3_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.909234
Perturb_2696_KO_SET1B_SRP089784	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.01573
GSK429286A	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.25
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-OLIG2_UNIQUE_DYS_GENES-NEUN_TLE_vs_TL_log2FoldChange_1_padj_0_1_OLIG2	Rummagene Transcription Factor Associations 2026	1.0	null
RIPOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27061
GSE221577_3_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
1893_CSE1L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.974106
primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30151
GSE156923_2_v_1_rbmx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF197	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19045
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.13974
Perturb_4904_KO_NSUN6_SRP233222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
MED10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0735
MCF10DCIS.COM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.958208
NARP syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.251
ETV5::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.124
GSE183113_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_3_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE94849_3_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4243378-13059_2014_494_MOESM1_ESM.xlsx-S1_6_Gene_sets_CIITA_BIs-All_CIITA_not_RFX5_RFX5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE143782_7_v_4_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233801
amygdaloid complex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19367
Perturb_17616_OE_FOXP2_SRP225889	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
A549_AC480_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208294
GSE114992,GSE114993_7_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154005
GSE146982_3_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1444
A549_Fasudil_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181097
GSE120413,GSE120447_4_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE227891_2_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
STAG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74952
GSE112763,GSE112767_2_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.969846
Perturb_9288_OE_KRAS_SRP172671	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.67814
TICRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82447
GSE94814_2_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Uterus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.16282
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15276
Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.8216
A549_Sodium Phenylbutyrate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166592
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.887985
inferolateral temporal cortex (area TEv, area 20)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.951907
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03114
Perturb_2324_KD_SF3A1_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.15965
Perturb_14903_KO_PRMT6_SRP125977	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.49622
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.448954
GSE191105_2_v_4_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0298
Perturb_3841_KD_NFE2L2_ERP105460	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.16127
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.36671
Perturb_467_KD_ADAR1/ADAR2_SRP253895	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	19.0969
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.55387
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36017
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6226
GSE155162,GSE155169_1_v_3_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HTK	CCLE Cell Line Gene CNV Profiles	1.0	1.38453
GSE130081,GSE130082_5_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210655_3_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
YAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3419
496100594_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.63202
ETV5::HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0214
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15011
Perturb_12726_KO_MITF_SRP255094	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.5543
K562_IOX2_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0342776
Perturb_9570_KD_CDH11_SRP318732	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.8198
GSE236003_0_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
molt4	HPA Cell Line Gene Expression Profiles	-1.0	-1.02082
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.57614
PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-upregulated_in_ATF4OE_txt-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
DD-74-PJ26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24959
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	154.137
A549_Fulvestrant_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161334
A549_Ki8751_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176429
5731_NOC4L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.610563
Perturb_15635_KO_MAT2A_SRP351305	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.97698
Perturb_9545_KO_Ucp1_SRP187003	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.20758
OVCAR-5	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.80848
K562_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162419
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.91232
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.255682
PHF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15399
FANCE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05791
GSE213588_9_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FADU	CCLE Cell Line Gene CNV Profiles	-1.0	-1.52137
SUPHD1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.23207
Perturb_2720_KD_YAP1/WWTR1_SRP115100	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.01899
TTC19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5831
Perturb_3122_KO_Slc6a14_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.8037
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.13194
Perturb_22_OE_Carhsp1_SRP217699	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.54215
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.97545
E2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0779
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cells - EBV-transformed lymphocytes	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.808177
GSE156923_0_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_16458_KO_CHUK_SRP229998	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20943
TBC1D22B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17336
K562_MK-5108_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019581
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.871305
A549_Alendronate sodium trihydrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148339
Tivozanib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.48
496100574_HIP_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.33623
GSE241036_0_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
2128_DDX52_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.848631
ovary_8a	HPA Tissue Sample Gene Expression Profiles	1.0	0.908421
A549_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136451
BC-13-OQ01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.677406
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.1646
Perturb_12140_KD_PRPF8_SRP093921	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9337
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
INPP5E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34712
FOXF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.271
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1369
TMEM222	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56161
SNU-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.04852
GSE249893_1_v_0_tfam_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Asimadoline	DeepCoverMOA Drug Mechanisms of Action	1.0	0.29
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.91323
GSE216043_11_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2113_DDX24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.544806
GSE155031_5_v_3_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE196117_6_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MDA-MB-231	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15276
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	103.153
Perturb_14500_KD_RUNX1_SRP265128	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.1517
6576_POP5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.517452
PIGM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08733
GSE191105_0_v_4_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nr1h2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.0931
496100640_PCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.45994
GSE85880,GSE85881_0_v_1_tretinoin_human	RummaGEO Drug Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.51486
GSE197555_0_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.114
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-0.948349
Rucaparib (phosphate)_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0117254
FZD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58
CAL-120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.879738
prostate_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.20991
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_3_in_RNA-seq_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE155972_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41493
2793_EXOSC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.619699
Perturb_13310_KD_Cnbp_SRP149831	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.34301
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.85125
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8707
EVSAT	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33935
ONX 0914	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.04
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.59661
Perturb_3914_KD_CTNNB1_DRP003300	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.19955
Perturb_5104_KO_Ythdc1/Dux_SRP251747	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.7931
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03916
GSE240344_1_v_0_uxs1_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.8797
GSE63048_11_v_8_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160817_7_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
DBP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5888
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.800616
Perturb_2301_KD_BRCA1_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.61075
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ETV2::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5006
2789_EXOSC2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.759739
SNU-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.4431
Perturb_3606_KO_ARID2_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.07537
SK-MEL-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.23124
Perturb_12946_KD_METTL3_SRP106608	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.0904
appendices_4b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.04099
Perturb_4710_KO_Sox9_ERP109172	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.11976
GSE154577_7_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.536182
HPBALL	CCLE Cell Line Gene CNV Profiles	-1.0	-2.17876
Perturb_12513_KO_ERO1_ERP137480	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.32853
MINDY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61673
Perturb_2329_KD_SF3B5_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.70109
DETROIT562	CCLE Cell Line Gene CNV Profiles	1.0	2.18475
A549_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180565
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26562
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05845
Brain - Cerebellar Hemisphere	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.18346
ABI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26679
Perturb_2105_KD_DHX8_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.21184
DMRTA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.265
GSE149264,GSE149267_4_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.06676
Perturb_15110_KD_PPHLN1_SRP218207	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.83832
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.991684
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.39844
2541_EIF2S1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.556857
PMC8423434-mmc7.xlsx-KLF4_HENSM-Genes_n_2172_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11906354-41588_2025_2087_MOESM4_ESM.xlsx-ST12-Unnamed_3_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Unnamed_13_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_8996_KO_KMT2C_SRP286164	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.27256
Perturb_4767_KO_Kap1_SRP065215	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.56959
chr2_37217630_C_T_b38	GTEx eQTL 2025	1.0	1.19099
NCIH211	CCLE Cell Line Gene CNV Profiles	1.0	1.55292
SK-N-SH	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15407
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_2_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
PD 160170	DeepCoverMOA Drug Mechanisms of Action	1.0	0.67
Perturb_13448_OE|KD_PAX2|PTEN_SRP279768	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.318
496100584_HIP_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.55588
6131_PCM1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00559
Ibutamoren	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.24
Perturb_5630_KD_EWSFLI1_SRP340258	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.79334
GSE146982_4_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HS 683	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.86252
DOHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.44959
Ro 28-1675	DeepCoverMOA Drug Mechanisms of Action	1.0	0.22
AMER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10723
OVMANA	CCLE Cell Line Gene CNV Profiles	1.0	1.42919
Perturb_3534_KD_KIF2C_SRP339333	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.40212
GSE135352_0_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE214442_0_v_1_pak4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SKNBE2	CCLE Cell Line Gene CNV Profiles	1.0	1.44519
Perturb_2325_KD_SF3A1_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.92583
PMC9248879-supp_gr.275831.121_Supplemental_Table_S2.xlsx-TP53-dependent_proteins-GeneName_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213048_1_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12396377-jcb_202307079_tables1.xlsx-Fig_1C_i_-_iii_right-y_TFEB_KO_LLOMe_VS_WTLLOMe_UP_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_7496_KD_EFTUD2_SRP192094	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.17178
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03413
2-PMPA	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
GSE171401_1_v_0_adnp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9509360-41419_2022_5262_MOESM6_ESM.xlsx-Fig_2D_MSC_targeted_RNF4-Down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
NUGC-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.824657
Perturb_5089_KO_Sall4/Sall1_ERP014607	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.73976
GSE120413,GSE120447_0_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.541832
496100592_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.43435
GSE123502,GSE123504_1_v_0_chd4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249835
orbital frontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10274
A549_Tozasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176804
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.809686
A549_TMP195_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161516
GSE184356_3_v_0_tfam_human	RummaGEO Gene Perturbation Signatures	1.0	null
SNU-398	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.72342
Perturb_11960_KD_RAD6B_SRP258673	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.3912
EIF4G2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88282
PMC9691391-7945884.f3.pdf-45-ENSG00000008441_NFIX	Rummagene Transcription Factor Associations 2026	1.0	null
BRMS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56671
GSE147662_3_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE113329,GSE113335_3_v_4_taf6l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.55928
Perturb_10051_KD_PRPF8_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.43024
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE155031_5_v_0_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FAM156B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2241
Perturb_7863_KD_METTL3_SRP226173	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.01232
PDXP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0708
thyroid_5c	HPA Tissue Sample Gene Expression Profiles	1.0	1.05683
JIMT-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.934324
GSE94849_7_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXB5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.476
Perturb_8113_KD_U2AF1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.33777
GSE167004_0_v_3_thpo_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_3947_KD_RNF6_SRP126561	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.04805
Perturb_6141_OE_PPP1CA/PPP1R8_SRP118980	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.01192
Perturb_14906_KD_LIN41_SRP032743	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.09473
COLO 849	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.59813
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12063
Perturb_3610_KO_BCL7B_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.44333
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.70409
GSE190950_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cervical squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.084
IDH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02421
Perturb_10058_KD_UCHL5_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.68887
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6279
CALU-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.27568
Perturb_4899_KD_TP53_SRP067400	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
KYSE-70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09545
GSE235701,GSE261434_2_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.4507
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.803679
PMC8200296-LSA-2020-00928_TableS2.xlsx-table_s2_DEGs_log2foldchange_0-Table_S2_List_of_DEGs_induced_by_YY1_knockdown_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
AGGF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0347
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15407
Perturb_7948_KD_SKIIP_SRP155347	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.72713
GSE144115_2_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CaSki cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.188
NCI-H2135	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.8816
GSE86507,GSE86509_7_v_9_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_16456_KO_CHUK_SRP229998	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_13004_KO_Upf2_SRP309261	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.65014
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271024
G84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.44799
Perturb_5735_KD_NAP1L3_SRP121475	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.09691
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.352
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_1_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
Brain - Putamen (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.24568
5748_NOP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.28743
1860_CREB3L3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.607303
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41493
OF-47-EQ74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.378446
GSE231720,GSE231724_2_v_1_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.64706
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.337226
GSE228992_0_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	1.0	null
HESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2458
Perturb_14678_KO_Prmt1_SRP153406	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
ETV4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02857
GSE124375_10_v_9_chd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE221539_1_v_3_lrrc10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217378_2_v_0_lin28b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.935809
Perturb_3629_KO_HDAC3_SRP355605	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.96764
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7037
Perturb_342_KD_GDF6_SRP076553	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	3.24385
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.899164
GSE93309_5_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_11927_KD_SMARCB1_SRP127642	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.8662
Perturb_2845_KD_FOXA1_SRP288463	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.5345
GSE100863,GSE100864_3_v_0_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
2543_EIF2S3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.507444
Perturb_9841_KD_KDM6A_SRP254623	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.36673
Perturb_13578_KD_Fem1b_SRP274135	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.86025
PMC10248509-Data_Sheet_5.CSV--GSE58294_DE-genes_AND_GSE66724_DE-Genes_AND_GSE41177_DE-Genes_NOT_Autophagy_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
ARHGAP45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03613
GSE228106_3_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_12290_KO_ERO1_ERP137480	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.90853
HT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.00371
Perturb_13278_KO_Mettl3_SRP254797	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.2071
Polysomal ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.385
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.988557
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.18741
GSE125219,GSE125221_4_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112763,GSE112767_4_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112761,GSE112767_1_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20943
HM7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.85026
Perturb_403_KO_FOXM1_SRP272209	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.53031
7518_RPS27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.529279
STX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44238
NKX6-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2402
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.535093
SU-DHL-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09775
GSE143782_3_v_4_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE88819_11_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226316_0_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199899_4_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
G118	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.838947
Perturb_18004_KO_Lrp1_SRP220333	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.35217
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20073
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.36927
A549_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110891
GSE190555,GSE190557_2_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SPRYD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02607
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201781
7536_RPS6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.987472
HCC1195	CCLE Cell Line Gene CNV Profiles	1.0	1.56267
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.349196
Perturb_13206_OE_Klf3_SRP281992	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	13.4573
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.634721
A549_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155983
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0458
Perturb_7383_KO_SMG7_ERP122822	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.98928
GSE114992,GSE114993_0_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE102467_1_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF597	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00691
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.846549
Perturb_10025_KD_TIAL1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.08414
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20943
Perturb_7558_Mut_ASXL1_SRP305063	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.52934
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.859934
Perturb_6458_KO_MTF1_SRP212065	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.53692
9366_TSR2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.546162
GSE198165,GSE198166_8_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IPPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26834
Perturb_9907_KD_EIF2S2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.11531
NRM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86407
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.482269
amygdaloid complex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12926
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.972474
Perturb_14886_KO_H13_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.45913
MG-132	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.96
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.1506
Perturb_3643_KO_DNMT1_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.2052
HSF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1805
HDLM2	CCLE Cell Line Gene CNV Profiles	1.0	1.41648
SCC-9	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.937707
GSE198165,GSE198166_6_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.98272
GSE94849_1_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.22301
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.623863
Perturb_14572_KO_EP300_SRP336466	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.42313
MLLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14818
G122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.33845
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.745196
G141	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.25757
HCC2218	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.920975
GSE189609_1_v_2_hax1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ABC1	CCLE Cell Line Gene CNV Profiles	1.0	1.75546
Perturb_7908_KD_SNRNP200_SRP364705	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE240809_0_v_1_hnrnpa2b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9399107-41467_2022_32627_MOESM6_ESM.xlsx-20_T-cell_subsets-gene_name_CD8_C1_LEF1_LEF1	Rummagene Transcription Factor Associations 2026	1.0	null
C13orf42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04963
Perturb_8160_KD_NSUN2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.00665
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259894
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290251
9226_TRAF2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.734325
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6282
ABCD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31501
GSE139016_3_v_2_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
HUH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.2869
AD-51-FB60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229204
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.29493
JURKAT, CLONE E6-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.14548
3861_HNRNPC_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05039
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.749584
HS729	CCLE Cell Line Gene CNV Profiles	-1.0	-1.69986
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.903648
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.68109
7522_RPS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.561811
9798_BUD23_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.34801
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42031
thyroid_5d	HPA Tissue Sample Gene Expression Profiles	1.0	1.64397
GSE171837_0_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_CUDC-101_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01369
Perturb_5061_KD_Cnot10_SRP251834	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.40048
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
chr2_37309345_G_A_b38	GTEx eQTL 2025	1.0	1.79642
u26684	HPA Cell Line Gene Expression Profiles	-1.0	-2.39936
Perturb_9035_KD_FOSL1_SRP320789	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.1014
Perturb_7403_KD_HNRNPA2B1_SRP010280	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.21548
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.832841
GSE111035,GSE111040_10_v_9_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_3068_KO_Apof_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.55369
7169_RBM28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.6118
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.96372
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26786
GSE190384,GSE190386_0_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE81803,GSE81912_2_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CENPE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1632
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.95
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.522054
RTKN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5048
Calu-3	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.82135
NFIL3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6865
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09636
Perturb_15476_OE_MYC_SRP218384	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.41196
Perturb_13518_KD_ILF2_SRP077068	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.70628
Perturb_2575_KD_LINE1_ERP011233	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.43215
ZNF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.7707
GSE121198,GSE129779_0_v_1_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
SRY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8214
A549_BMS-911543_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164747
GSE171837_3_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ARCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19219
HOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2958
6534_POLR1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.922601
K2	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.90519
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1291
Perturb_9985_KD_U2AF1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.66696
GSE193258,GSE193259_9_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210655_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.6974
FUOM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25811
GSE149075_2_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20287
A549_Disulfiram_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153026
GSE183335,GSE183351_3_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.41035
624 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16741
176_AFG3L2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.672419
DDX49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23481
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04426
LOX-IMVI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.831776
A549_Decitabine_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013165
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20852
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DLGAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43227
P31-FUJ	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.67509
CE-69-HJ13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269383
Perturb_13022_KO_ALOX5_SRP367905	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE253943_1_v_2_bhlhe40_human	RummaGEO Gene Perturbation Signatures	-1.0	null
9682_UTP15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.606117
MDA-MB-468	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.31301
GSE207611,GSE207612_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE130246_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_13450_KD_Hnrnpk_SRP146257	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.39643
Perturb_7696_KD_SNRNP200_SRP364705	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_10352_KO_AATF_SRP257744	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.54603
Perturb_2801_KD_RBM39_SRP245602	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.80377
GSE93124_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193993_5_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HBA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17684
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4739
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ACSM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74555
Perturb_5870_KD_Cpsf7_SRP336206	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.10914
GSE202434,GSE202438_6_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.902048
GSE146982_4_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_8993_OE_LIMA1_ERP128082	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.69232
BF-97-LS55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207559
DNASE1L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71015
NCI-H2228	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.915614
SCC-25	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.37146
Type I spiral ganglion neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
Perturb_5391_KD_DEANR1_SRP019241	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.77194
GSE169205_3_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.54709
2102_DDX10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.601166
HOXC8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5882
PMC8160578-JCB_202009147_TableS4.xlsx-MYBL2_targets-Genes_n_532_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE234289_4_v_0_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE102870_5_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
HOXD13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21402
TUBB4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69499
Urinary bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.191
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.319374
HOXB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4018
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41291
Perturb_3930_KO_FURIN_SRP197346	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.75954
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.871058
M059J	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.2092
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.319301
amygdaloid complex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01791
496100590_FWM_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.23892
GSE233679_14_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
NR3C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5383
DMS454	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4208
GSE219274,GSE219276_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
AMFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66463
GSE138468_3_v_6_dyrk1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CEBPZOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45379
Perturb_17612_OE_MYC_SRP301619	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.62023
GSE94849_6_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HS 852.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.887974
9841_WDR75_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.56784
Perturb_6480_KD_SNRPB_ERP011528	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
HLF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4823
UACC893	CCLE Cell Line Gene CNV Profiles	1.0	1.53226
Perturb_7290_KD_CNOT1_SRP099077	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.41897
Cecum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.025
GSE146982_3_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.72963
Perturb_9348_KO_CDKN2A_SRP158425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.89217
A549_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173618
Perturb_8153_KD_BOP1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.53306
SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5725
QRICH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02441
TIMM23B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07013
Perturb_10651_KD_Syncrip_SRP065017	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.4516
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242411
MCF7_Prednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149097
GSX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21654
PSMD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33467
HS 695T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.37004
GSE196671_6_v_8_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE86021_0_v_1_crenolanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE211262,GSE211263_3_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OV7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05543
GSE217115_2_v_4_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15276
Perturb_16086_KO_Bap1_SRP270239	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.79923
LXF289	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41506
9909_XRCC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.792158
SLC25A27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51493
GSE146982_4_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HIF-2alpha_DEPLETION_GDS2760_643_human_Hypoxic MCF-7 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE250089_0_v_3_epcam_human	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.891353
GSE224547_1_v_0_cftr_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_7243_KD_CNOT1_SRP285534	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.24746
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.645291
HSF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1869
GSE184902_4_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2367_DPY30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.697123
JF-62-LU77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255721
Perturb_7852_KD_XAB2_SRP193107	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.37814
Perturb_5394_KD_LIM1_SRP402415	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	19.699
Perturb_7179_KO_TrEx_SRP163035	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.73949
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BGC823	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37491
6963_PWP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.552086
spleen_3b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.82392
SEC62	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12457
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.610999
A549_Mercaptopurine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177213
PMC11665843-SYB2-18-218-s001.pdf-132-TCF12_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.77504
A549_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147162
Perturb_9151_KD_DDX21_SRP327839	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.72632
SNU-719	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.887985
GSE133763_0_v_2_chd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.36984
9366_TSR2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.672646
Perturb_14194_KO_ALPG_SRP277076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.5636
KALS1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36652
Perturb_326_KO_CDK12_SRP334730	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.8038
K562_Fasudil_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188785
A2780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48138