association	dataset	threshold value	standardized value
CDX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.965
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.6188
496100384_HIP_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.79307
ALX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.043
SOX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0528
LHX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.801
BARHL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1576
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE140997_10_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2263
PDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9448
Exotropia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.424
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7909
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.339
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0288
GSE99687_0_v_1_smad5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Inguinal hernia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.128
Condensed chromosome, centromeric region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.243
CDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6982
HOXD9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.7094
POU6F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64516
RAB1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60581
GSE176008_0_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Syndromic X-linked intellectual disability Turner type	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.155
RHOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97539
FAM117A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42889
496100419_TCx_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.58503
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6014
YBEY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6745
HES5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7827
SCRT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2416
non-syndromic X-linked intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.583
DMRTC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9942
GSE205976,GSE205978_3_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.8551
Syndromic X-linked intellectual disability Siderius type	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.115
ZNF75D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.2955
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3663
GSE129241_4_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
DHCR24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85564
ISX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7509
LBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.9774
496100586_HIP_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.37855
TLX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9094
HEY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9975
PMC11474056-pnas.2404841121.sd01.xlsx-Supplemental_Table_8_Fig1G-H-Supplemental_Table_8_Transcriptomic_overlap_between_LPS_and_Sepsis_and_or_Tuberculosis_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MIXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.9684
MEOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5406
FG syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.643
EN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0576
SOX12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0952
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.4159
NFYA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.578
POU3F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1456
FOXO1::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0601
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.8318
MTF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9517
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8633
RBM28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13269
GSE176008_7_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.947
ZSCAN21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2429
ZNF558	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	84.1634
DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0937
496100572_HIP_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05034
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0246
NOTO	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.785
496100615_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.0337
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8124
FOXC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8744
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.0297
SRF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1482
GSE128054_1_v_0_myt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4612
ERF::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0953
Syndromic X-linked intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.828
FOXO1::ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9459
BCL7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58
Amblyopia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.218
GSE210682_0_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.38
FOXN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4589
FOXD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8
RAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.9967
GSE129241_3_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.1104
PCBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00989
DUX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9802
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5208
GSE182680,GSE182683_7_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.0142
GSE150072,GSE169209_4_v_10_qser1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0556
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.9875
Translation release factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.678
ZNF766	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1439
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3488
UNCX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.9685
ESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.429
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7105
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2178
496100573_HIP_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.03184
SRY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1786
GSE162892_4_v_5_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.0741
POU5F1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5869
PAX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3522
POU2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6138
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.7079
Whole Blood	GTEx Tissue Gene Expression Profiles 2023	1.0	5.05159
MNX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.5848
ZNF274	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5471
496100445_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.44291
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.211
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7086
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1906
496100659_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.14164
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4093
NOL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.9248
ZNF417	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5696
GSE222758_0_v_4_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_7_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HES2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1359
RORC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4446
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.4567
POU2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2668
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7234
ETV5::HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0104
GBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4546
ZNF324	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0376
Syndromic X-linked intellectual disability Claes-Jensen type	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.069
EMX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.3891
496100513_TCx_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.75845
PMC10245467-mmc3.pdf-271-ZNF385C_ZNF385C	Rummagene Transcription Factor Associations 2026	1.0	null
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.7847
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Down_bins-Down_bins_loosing_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
FOXG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2465
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8764
BAG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0622
PROX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7744
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.2503
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.8522
496100374_HIP_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.66948
496100539_HIP_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.70041
HOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.3284
NFATC3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8775
GSE176008_8_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5807
POU3F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0511
RAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6481
Syndromic intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.693
Kinetochore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.243
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.6563
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4172
OSR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5344
ZNF675	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.5518
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0233
non-syndromic intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.318
Pituitary	GTEx Tissue Gene Expression Profiles 2023	1.0	5.05159
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.6972
MSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5744
ZUP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56553
Strabismus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.103
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8871
496100656_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.26399
Stocco Dos Santos type X-linked intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.458
BTBD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47552
PRRX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8538
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3653
DLX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7104
PRRX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7342
SOX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.6786
ZNF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2468
SDHC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91076
RARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4783
FKBP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02496
GSE138863_3_v_0_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE172016_2_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETV5::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.7043
496100383_HIP_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.48104
GSE182680,GSE182683_10_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2132
EMX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2416
Synaptic vesicle protein transport vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.258
Syndromic X-linked intellectual disability Najm type	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.863
WDR75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22282
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.5177
CDX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4888
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1468
PSIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90579
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZKSCAN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.762
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0485
IRF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.1144
TTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35869
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ETV5::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.6792
GSE139016_3_v_2_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0826
496100491_HIP_no dementia_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.74037
GSE182680,GSE182683_0_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.8773
Chromosome Xp11.22 duplication syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.394
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4009
GBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5025
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3148
ETV2::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4044
Laryngomalacia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.596
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.149
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.1639
GSDMD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02334
GSE182680,GSE182683_7_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.4936
RHOXF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.4595
496100622_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	5.22719
MSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.3626
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.149
RARA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.9058
FOXP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.4618