association	dataset	threshold value	standardized value
BRD-K49461735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0088
BRD-K36074653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65005
GSE146982_3_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TLK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540872
BRD-K52094743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13952
AD-00-WA10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.22872
BRD-K33037101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76315
NC-52-HX69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204358
ZC-47-HL31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.383823
PTPRO	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00413361
BRD-K16267084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60965
BRD-K37203382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35416
CRCGN010_HEPG2_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.48975
BRD-K07276273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36544
6548_POLR2G_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.614228
BRD-K99000702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71765
CRCGN015_MCF10A_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5873
8886_THG1L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.690496
GSE140646_0_v_1_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149264,GSE149267_4_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
5078_MINPP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.909949
BB-86-BE39_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.432334
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.26783
CRCGN015_MCF10A.TP53.M_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7406
PRKCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49644
NCIH1573	DepMap CRISPR Gene Dependency	1.0	2.46505
JD-87-MR82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30873
KE-73-XV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.20031
NDUFC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0042358
CRCGN017_MCF10A.WT.HP_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2138
BRD-K92433763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02123
PMC9270251-mmc2.xlsx-2_Filtered_DEGs_Control_vs_KD_2-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160817_2_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
P3H3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00432051
BRD-K44371786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03362
6801_PRPF4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.623762
BIN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00724945
AB-09-JN93_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264622
DA-07-LL18_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249088
BRD-K41033343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74242
BRD-K83934572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52613
CREB3L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14664
GSE206226_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.784119
interstrand cross-link repair	GO Biological Process Annotations 2025	1.0	null
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.177
CRCGN011_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0036
BRD-K68547601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2289
CRCGN012_HEPG2_24H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.43601
Blastodisc	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.67
BRD-K06208179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33725
BRD-K10900122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66409
DNA recombinase mediator complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.074
CRCGN016_MCF10A.TP53.M_24H:E21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15224
GSE158834_10_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CA-72-JV60_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209186
Body Height	DisGeNET Gene-Phenotype Associations	1.0	null
MF-04-HB41_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.57549
BB-85-NU70_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237479
YE-80-LN04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.486093
GSE92614_1_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K65291993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11803
GSE140607_0_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.90232
GSE165916_1_v_2_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CB-12-HC20_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.403579
BRD-K29806938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01877
937_BUD13_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.500623
CDS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09326
GSE135030_3_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
AB-21-MV93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.279492
BRD-K70315531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56901
BRD-K56916066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.36608
BRD-K40221630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9473
SUPT7L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0055726
WB-92-TT14_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215523
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE93309_2_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MHHNB11	DepMap CRISPR Gene Dependency	1.0	2.75706
BTAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5523
IGFN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00587769
GSE200430_1_v_0_sema3d_human	RummaGEO Gene Perturbation Signatures	1.0	null
BHLHE22	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9228
IDH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00603931
CRCGN016_MCF10A.WT.HP_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1599
PMC12455829-11658_2025_792_MOESM8_ESM.xlsx-2_DDIT3_IP_vs_BRG1_IP-Supplementary_Table_7_Transcription_factors_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.85545
9478_UBA1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.561801
CRCGN017_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.34567
HC-83-TS50_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221965
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DB-69-JG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234515
FF-01-OH44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.401832
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2776
BRD-K49704392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.71937
BRD-K66214486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.73503
CRCGN013_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09994
JF-39-BZ76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.356805
GSE115395_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31165
Sleep disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.553
CRCGN016_MCF10A.TP53.M_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.9659
CF-83-HM41_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.366577
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ND-27-UQ99_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248816
3335_GEMIN4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.545404
HS729	DepMap CRISPR Gene Dependency	1.0	2.84312
CRCGN015_MCF10A_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.5927
BRD-K51572611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87206
GSE118765_1_v_5_rreb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ATR-ATRIP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.72
CRCGN010_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3065
DOCK10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00628115
PMC9038526-mmc1.xlsx-postCOVID_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216043_11_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE196259_2_v_3_gcm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE161800_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE81803,GSE81912_0_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.565105
AB-05-FB25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262466
BRD-K53900606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60482
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.64428
BRD-K07351191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07299
496100472_PCx_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.20404
BD-81-LB65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259556
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.83661
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2027
BRD-K86961579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20254
BRD-K64317740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.206
CD-75-QY45_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.323559
Condensin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.273
BRD-K72774661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08338
FB-98-HM88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.573462
S0-EE-WJKI_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275541
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206057
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.6075
CD-75-QY45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238718
CD226	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00680211
BD-38-QC39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.04147
DF-70-CD57_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.315905
TA-21-GI75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22208
Helam	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.51
JF-62-LU77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.538609
NMB	DepMap CRISPR Gene Dependency	1.0	3.01283
ps90	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.065
CRCGN017_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.68115
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0572
BRD-K36104357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15452
UMUC14	DepMap CRISPR Gene Dependency	1.0	2.83711
GSE136232,GSE136234_0_v_1_zpbp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Malignant ovarian surface epithelial-stromal neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
WD-62-UB45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204261
FD-20-OG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.84431
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.38419
IGSF10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00540627
GD-90-RA90_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206648
HO1U1	DepMap CRISPR Gene Dependency	1.0	2.42783
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
HC-26-PX74_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.380917
RD-90-OY66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.323911
MON	DepMap CRISPR Gene Dependency	1.0	2.24929
CRCGN014_HEPG2_24H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00696
BRD-K28216304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44884
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PB-66-RW16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228086
8230_SNRPD3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.619349
AC-50-FR41_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.87101
BD-99-DU20_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.309037
TRAF4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00524739
MPP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00733388
Microtubule plus-end	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.916
BRD-K19320442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05553
BRD-K70090544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64812
K562_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146188
GSE180185_7_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SKNFI	DepMap CRISPR Gene Dependency	1.0	2.10026
Rhp55-Rhp57 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.106
GSE218060_7_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ME-93-CO85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256793
AC-93-LT43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.411053
GSE112714_2_v_3_ctnnb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
WC-16-IR43_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.588772
ED-71-GA72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.0837
ME-42-RD46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.457448
BRD-K94378105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30265
FF-96-HL81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.03255
BRD-K12801140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24351
7658_SART1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.535787
PMC13127299-mmc2.xlsx-PBX1_kdRNAseq-hgnc_symbol_PBX1	Rummagene Transcription Factor Associations 2026	1.0	null
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	150.336
MutS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.001
6851_PSMB3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.509214
BRD-K49472569	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41526
RSPRY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25945
MAPK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00421125
FB-85-ND09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243071
MCF7_UNC0379_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124357
GSE225447_1_v_0_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.1654
HD-18-YL30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.716092
Chiasma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.63
BRD-K65875972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03987
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PIP4K2C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00723512
BRD-K37328981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36169
BRD-K58005972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14194
ICOSLG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00750392
ISHIKAWAHERAKLIO02ER	DepMap CRISPR Gene Dependency	1.0	2.98246
CIB4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00665031
SMC loading complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.153
CRCGN017_MCF10A.WT.HP_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1371
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.85799
NCIH2122	DepMap CRISPR Gene Dependency	1.0	2.39238
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.5237
BRD-K93488589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24109
SYF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23371
CRCGN016_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.36019
CRCGN017_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.64605
BRD-K91511557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22769
GSE165647_2_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2292_DNAJC19_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.679251
GSE62292,GSE62295_2_v_0_col4a3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.15237
Kinetoplastid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.203
BRD-K77922263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09734
BRD-K52473839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06395
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.60532
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
6611_PPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.503474
GSE158975_0_v_1_spp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Transcription export complex 2	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.674
BRD-K02087489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03904
AC-37-OZ52_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2618
BRD-K30964167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.45919
GSE178255_5_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-25-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.839553
GSE239578_0_v_4_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K26863838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05708
Kinetochore	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
CCNA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00374808
Nuclear replisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.952
JF-39-BZ76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2368
OE-34-NH10_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.335213
BRD-K30171122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10759
SA-53-XG95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.70376
MD-40-FM63_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205979
K562_WHI-P154_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157949
BRD-K11399565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71207
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.76874
496100378_TCx_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.4559
BC-88-KT45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.307539
POU2F1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN009_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.79801
AD-86-ES28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.723471
KA-29-AB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.16852
MB-46-BT89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.627173
GSE149901_2_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE159678_6_v_7_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K46014293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26667
CRCGN016_MCF10A.WT.HP_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.71487
BRD-K52237706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52158
GSE125782_3_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DNA binding	GO Molecular Function Annotations 2023	1.0	null
JE-86-QG78_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.303718
VTCN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00689812
CRCGN015_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.68148
Urinary bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BE-46-FY47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207069
CRCGN017_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.11205
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K68009914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.096
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.8228
BB-79-AG41_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.476956
BRD-K76426411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58471
GSE200352_1_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186005_1_v_2_klf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DPY19L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19256
CRCGN012_HEPG2_24H:A05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06646
HD-41-DX72_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30646
CRCGN017_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.58489
GF-57-LR72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.328265
BRD-K20073772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84675
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.908024
BRD-K94744294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64094
CRCGN014_HEPG2_3H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0042
GSE231891_3_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K41272069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75191
BA-39-HG26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.321639
DF-00-BU08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.452643
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.71873
SC-17-WW78_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241693
interstrand cross-link repair	GO Biological Process Annotations 2023	1.0	null
EF-01-LB20_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.274662
BRD-K67902591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49291
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.51482
CAMTA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00573924
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.64626
SLC1A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0061398
GSE202603_3_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE139239_3_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-61-OO16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.99483
CRCGN017_MCF10A.WT.HP_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12457
QA-58-CX23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.539097
DA-27-BW40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225805
Spindle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.801
CRCGN016_MCF10A.TP53.M_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2266
BRD-K64626569	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19064
regulation of protein ubiquitination	GO Biological Process Annotations 2023	1.0	null
NB1	DepMap CRISPR Gene Dependency	1.0	3.05542
PMC8010105-41598_2021_86504_MOESM2_ESM.docx-0-CENPS_CENPS	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K39681206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.30563
Fanconi anaemia nuclear complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE84922,GSE84924_4_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Xeroderma pigmentosum	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.401
GSE206516,GSE206518_5_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Fluorouracil_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125489
BRD-K50497551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30345
YA-85-VH07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.486926
NDUFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3892
BRD-K02078984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28007
BRD-K24532125	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46989
10136_ZMAT2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.513654
GSE86507,GSE86509_7_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K21423945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58487
BB-72-TP61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20516
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.76338
Origin recognition complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.839
BRD-K73391462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21675
AB-85-JR73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.517023
GNA11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08138
EF-75-JG46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.40675
DOK6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00671778
GSE249893_1_v_0_tfam_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GD-82-CS38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.375914
BE-17-CS60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.08046
CRCGN010_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.80148
4150_INTS5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.911645
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BF-49-KQ10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203228
GSE158834_10_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.42723
Heart - Left Ventricle	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.878722
GD-82-CS38_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269047
A549_JNJ-26854165_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0253015
NMS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.304
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.2923
KF-18-RY71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.274761
ACF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.702
EC-17-MF19_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.356008
GSE193258,GSE193259_5_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K06320746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10952
BRD-K89932793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09626
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.46656
CRCGN015_HEPG2_48H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.63074
2541_EIF2S1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.76709
8535_BHLHE40_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-1.01743
CRCGN016_MCF10A.WT.HP_24H:K15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60696
AB-12-PP61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.342032
938_BUD31_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.563933
YF-77-FV50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.655552
CRCGN008_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.6243
CB-99-OG76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.344903
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.15758
CRCGN015_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23423
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.91687
BRD-K29636267	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23159
ZNF366	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16777
HB-92-PE54_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.319001
Mitotic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.395
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.01815
PPP2R5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41842
Caulonema	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.913
WDR12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00677039
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.658746
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.93168
FF-90-JK74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.407452
AC-36-TL21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245315
9909_XRCC6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.566734
GSE227127_1_v_0_diclofenac_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.6932
BRD-K56086519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.80113
4944_MED21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.651015
CRCGN015_HEPG2_48H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24795
CCDC86	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22626
KA-71-CQ35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.388056
GSE206516,GSE206518_0_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SC-25-HE80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.43147
CA-90-RU33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.653287
CRCGN010_HEPG2_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0523
PMC11143964-jciinsight-9-161356-s009.pdf-13-SMAD5_SMAD5	Rummagene Transcription Factor Associations 2026	1.0	null
IKZF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00346872
AB-18-YN11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.392724
UE-02-UW61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265144
BRD-K93339508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32652
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.84683
Nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.435
DB-34-QA60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.394101
GSE213588_8_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4152_INTS7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.777785
9703_VARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.521301
CRCGN009_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.69356
BRD-K31952722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75175
BRD-K19817946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07794
GSE252988_0_v_1_lefamulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LE-94-HL75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285398
GSE110178_4_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Nuclear chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.665
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.591794
BRD-K67027685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56067
GSE200673,GSE200691_1_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SC-17-WW78_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270736
PLS3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00583353
SYPL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00562055
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.0272
PRDX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0101985
Mis6-Sim4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.049
BRD-K21466747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22287
IE-28-SY71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.39968
HF-57-QB74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.287026
DA-10-HD17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.385722
Outer kinetochore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.496
BRD-K49721311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65377
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K08416835	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04295
BMPR1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0047499
STAT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00556784
WNK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55308
Kinetochore microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.875
CRCGN011_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.64595
GSE202434,GSE202438_6_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K75148160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32263
CHAF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13443
BRD-K67200393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57702
BRD-K99847716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0127
BRD-K10398797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20489
BRD-K73840377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60494
CRCGN016_MCF10A.TP53.M_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3012
CRCGN015_MCF10A_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2723
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K25149224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28538
AF-41-QY60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.3474
FC-19-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217526
BRD-K61199074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35789
GSE223008_5_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K88441035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56181
BRD-K24599650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00774
GSE120595_0_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF749	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45815
BC-13-OQ01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.452124
ITGA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00618774
FC-19-RM40_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233227
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6042
IL4R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.004279
BRD-K56285711	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09721
VA-06-DB75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.54912
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.26319
GB-81-GK41_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223853
CRCGN014_HEPG2_24H:G03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.32137
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.05475
CRCGN016_MCF10A.WT.HP_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.15099
CRCGN014_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.02035
BRD-K13317726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39384
PC-68-DU31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.06805
DA-15-PU65_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.507885
PMC8816731-41388_2021_2128_MOESM8_ESM.xlsx-TF_Downregulated_by_SNAIL1-Unnamed_2_SNAI1	Rummagene Transcription Factor Associations 2026	1.0	null
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.950223
ARPC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00656611
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.388727
CRCGN011_HEPG2_24H:P02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25305
GSE206516,GSE206518_3_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LEFTY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28379
AC-43-ZC52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.547587
KE39	DepMap CRISPR Gene Dependency	1.0	2.39289
HF-73-FS05_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213455
496100605_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05454
Brain - Substantia nigra	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.53301
BRD-K35588268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27611
MD-49-BL92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.370557
BRD-K41517267	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53557
BRD-K71605668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14222
GSE124471,GSE124488_1_v_0_lats1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169205_3_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BA-84-TD72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.96657
NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.9987
BRD-K99644502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4323
DD-42-DB72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23919
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.733
NKX2-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6376
GSE203158_0_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NPY1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30034
GSE201042_6_v_1_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
1943_CTR9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.800036
CC-47-VS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.51167
ZNF581	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5515
g2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.168
GSE189356_5_v_6_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SD-51-LL22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.41299
GSE149264,GSE149267_4_v_5_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K91216645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1903
FE-69-HJ93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.559713
BB-93-VT73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.731395
RAD23B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00404694
GSE225656_2_v_3_tsc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE258991_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6032_PAF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.78417
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.07536
CTCF-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
HDAC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00562609
positive regulation of protein ubiquitination	GO Biological Process Annotations 2025	1.0	null
PMC5986128-pone.0197176.s008.xlsx-Sayfa1-PISA_symmetry_ZNF568	Rummagene Transcription Factor Associations 2026	1.0	null
Ino80 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.092
BRD-K03675705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41918
BRD-K80888333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00856
BRD-K24557107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94829
MARVELD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41763
8669_TAF7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.600961
CA-00-AR16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.28007
GSE158632_2_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE201309_4_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UF-98-OM26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.417169
CAPNS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5063
PD-60-FM93_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204132
BRD-K48691065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.38272
DNA repair	GO Biological Process Annotations 2025	1.0	null
PMC11409756-13062_2024_533_MOESM1_ESM.xlsx-Sheet1-Table_S1_Differentially_expressed_genes_DEGs_regulated_by_ZFP64_through_mRNA-seq_ZFP64	Rummagene Transcription Factor Associations 2026	1.0	null
GSS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16162
JE-55-OJ53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277249
GSE206226_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_SB431542_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125083
GSE151612_0_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHST7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38402
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.14556
AC-57-ZF49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21842
GSE48812_4_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146982_3_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNU685	DepMap CRISPR Gene Dependency	1.0	2.93087
GINS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.316
MCF7_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0101653
Fanconi anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.797
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.597564
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.20404
CD-59-PT17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302138
DSTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11584
DC-23-UM36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.319069
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.71131
BRD-K08658757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29413
CRCGN016_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.81175
BRD-K91399333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23386
Common Variable Immunodeficiency	DisGeNET Gene-Disease Associations	1.0	null
GSE203060_0_v_2_kdm4c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-58-FJ71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.354134
Skin	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE165307_3_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:I07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44885
CRCGN017_MCF10A.WT.HP_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2247
LC-96-WR85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.438202
AF-80-GK24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.651857
DA-85-SU90_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214075
BRD-K91885806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82473
GSE147283_1_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169152_3_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.59555
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-11.0449
KC-32-GO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.872964
CRCGN014_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21206
BD-69-XG81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.373192
FA-43-XS35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217791
GSE262134_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE93309_2_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217541,GSE217543_0_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
OE-78-TD20_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.6879
BRD-K75410936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07759
BD-18-MM33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.328716
BRD-K40219231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26114
CRCGN013_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.13608
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K69154646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.42804
Chela	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.539
PF-59-CY33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.88451
BRD-K51322795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01819
CRCGN016_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.40293
GSE130246_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE197562_0_v_3_nox4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:I07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30009
HD-19-IW09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.661523
CLMP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06347
BRD-K23440419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51759
BRD-K20331065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84325
9212_TPRKB_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.563115
CRCGN013_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.96763
CB-12-HC20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.37059
Flp-In-T-REx cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.919
GSE120595_5_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BE-46-FY47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.284695
Microtubule bundle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.593
AC-31-SL44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.29862
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1715
Stomach Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K50721666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.42789
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.609617
Metabolic Syndrome X	DisGeNET Gene-Disease Associations	1.0	null
Fanconi anemia complementation group T	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.015
GA-77-MH38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.97997
AE-04-SN76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.758045
Type II site-specific deoxyribonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.715
BD-38-QC39_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.569724
LA-69-OL77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272292
Vegetative stage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.644
MYOG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.0464
BRD-K87742870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1005
TMEM106C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00661
XA-39-SG64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243555
9475_U2SURP_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.59321
GC-04-UF36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255891
BRD-K45717258	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90086
BRD-K00808919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02906
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.46
CRCGN010_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45275
HF-35-HT37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293161
ZNF80	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00523247
BD-93-AM31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262985
BRD-K55414200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0644
K562_GSK1070916_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138192
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
AB-85-JR73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207841
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.68767
ERGIC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00822446
RHJT	DepMap CRISPR Gene Dependency	1.0	3.02723
BRD-K45833502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73015
BRD-K13007223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04447
GSE220806_1_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BEX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06951
AB-30-CR11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294141
Nuclear replication fork	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.04
BRD-K76175734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04945
GD-79-JJ38_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.356367
CRCGN016_MCF10A.WT.HP_24H:E21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1427
BRD-K04147413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49837
BD-69-GX17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.405368
SF-21 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.795
BRD-K07196884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21546
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.3221
NE-00-JZ19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.65274
GSE102675_3_v_0_atf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FC-85-OX77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.07941
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.58822
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.2089
TD-48-XJ84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.72825
CRCGN015_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.5858
VDAC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00672268
FURIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22409
GSE205730,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K93032100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67234
AA-94-TU18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.713949
CD86	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00590855
2613_EMC3_P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.584996
STAM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00545127
BRD-K32782599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34979
6548_POLR2G_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.548759
JA-77-UH38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219529
BRD-K40264914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34796
5493_NCBP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.504398
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3868
BB-79-AG41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.75535
BRD-K68055156	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07403
BA-84-TD72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.39666
Pancytopenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
DA-28-TM43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.310251
DE-05-NX87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.447828
PMC11465086-mmc2.xlsx-Table_ES_1_markers_c0_LPS_Vs_Co-Gene_Expression_Data_1_markers_c0_LPS_Vs_Control_related_to_Figure_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K44908880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43647
CRCGN016_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.78092
GSE182680,GSE182683_7_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE116810_2_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
3869_HNRNPK_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.620126
BRD-K25907192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.808
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.75705
A549_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145157
Esophagus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.204
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.454
EE-03-SG02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.600663
HD-51-KD29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.726081
GSE110268_0_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB38	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00750144
BE-46-FY47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.313083
CRCGN009_HEPG2_24H:N19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.80779
YB-79-DM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248407
BRD-K45272675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1289
PB-18-HD85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305808
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.24438
BRD-K17303020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.54656
BRD-K51666223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77867
BRD-K29028138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.42821
DA-81-VY50_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.741908
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.645889
CRCGN014_HEPG2_24H:J13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19826
7424_RPAP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.872491
ABCC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0048325
ZNF684	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55936
GSE217541,GSE217543_3_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3201
BRD-K45112293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08636
BRD-K93148720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10336
BRD-K40804250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34697
AA-62-HP31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.590121
BRD-K48835953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09353
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.422953
CRCGN016_MCF10A.WT.HP_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.33026
SNU387	DepMap CRISPR Gene Dependency	1.0	2.09529
GSE213588_9_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22969
GSE84148,GSE96938_0_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.62328
BRD-K75534737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12754
BRD-K24387453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19379
BRD-K10696228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1335
BRD-K03470412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47995
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268664
Fanconi anemia pathway	KEGG Pathways 2026	1.0	null
TCL1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00633608
SIPA1L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00545177
CE-74-KU68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.306861
PC-63-CH43_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.315447
BRD-K37213205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35722
positive regulation of protein ubiquitination	GO Biological Process Annotations 2023	1.0	null
QA-81-IM40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212014
GSE148692,GSE148695_7_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZC-47-HL31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.423761
VC-19-YG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.94701
AA-48-GT70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285597
7842_SFPQ_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.525546
JHUEM1	DepMap CRISPR Gene Dependency	1.0	2.86995
PATL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00598096
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247694
Inner kinetochore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.908
CD58	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00513288
RBM11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41496
LD-47-RN92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.462594
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.04833
BRD-K10241968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16503
Phragmoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.147
ARFGEF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00437275
A549_Veliparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016272
BRD-K06219419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54062
PMC9270251-mmc2.xlsx-4_Filtered_DEGs_Control_vs_KD_3-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K60296400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51258
2858_FAM136A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.577793
TA-19-YA45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.485106
PMC11399095-44161_2024_532_MOESM7_ESM.xlsx-Sheet1-Supplementary_Table_6_DEG_of_hyperexpanded_clones_in_EAT_vs_AA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
MF-11-EW49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.369506
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.600871
ID-26-HX79_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290868
Head and neck carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.032
HDAC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00500592
BRD-K44624253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03134
BRD-K21729626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02131
BRD-K23503923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7954
GSE232786_1_v_0_otud1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.64145
PMC6167382-41467_2018_6258_MOESM4_ESM.xlsx-TEAD-associated_GSC-Specific_UP-Nearest_Ensembl_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
TCEAL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00506659
BRD-K84271229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97796
CE-04-PX35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248045
CRCGN009_HEPG2_24H:J04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11055
CRCGN016_MCF10A.TP53.M_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29159
PMC11511861-41420_2024_2216_MOESM2_ESM.xlsx-siYAP_myc_bound-MYC_targets_from_chipseq_atlas_at_least_2_chip-seqs_over_4_in_A459_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226983_2_v_0_ddx5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K80736363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26805
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.78601
CRCGN008_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00425
BRD-K34620971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53419
HC-76-HU27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2314
GSE126463_1_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152432_6_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BE-17-CS60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.42803
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.58997
PIP4K2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00320394
BE-03-XC62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.311325
6981_QARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.784299
GSE126463_5_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Disulfiram_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149936
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.352
PCCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15257
BRD-K91897530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09459
CRCGN008_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3756
KC-48-OO62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209816
SH3BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36674
KC-67-HN97_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.434992
BRD-K49029187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81161
TF-04-RX73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24532
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.553
BRD-K67460571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67135
OLR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00754992
GSE161295_0_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227592_13_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Metaphase plate	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.46
BRD-K46936325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02102
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GA-16-IU17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.5465
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
decreased locomotor activity	MGI Mouse Phenotype Associations 2023	1.0	null
MutSalpha complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.307
496100349_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.3146
SULT1B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0080589
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111247_0_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UF-14-LK87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.717536
CRCGN008_HEPG2_24H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9083
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.18356
Restless legs syndrome	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.435
AD-55-WK61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300086
CRCGN015_MCF10A.WT.HP_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13643
BRD-K69269415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31732
BRD-K41412255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26355
CRCGN013_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45035
A549_Busulfan_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023338
DD-64-ET45_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264794
CRCGN008_HEPG2_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0607
CRCGN017_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6824
LB-58-KL25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210454
DNA repair complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.614
1893_CSE1L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.572757
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.80335
IA-48-KI53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.407743
AF-67-LZ82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.97631
HE-99-KP87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.306574
978_C14ORF178_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.630143
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K20368781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27356
BRD-K75331656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04235
FD-91-OK66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.384264
GSE200673,GSE200691_2_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.2402
AC-30-XU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.908256
QB-69-QH67_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212098
GSE115395_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.08892
CRCGN015_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.43505
BRD-K12866026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74439
BC-01-JL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.86229
BRD-K57349002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49682
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
positive regulation of protein modification by small protein conjugation or removal	GO Biological Process Annotations 2025	1.0	null
RPS6KB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00455232
PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11931126-Table_2.XLSX-gene_list-AKAP8L_AKAP8L	Rummagene Transcription Factor Associations 2026	1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-13.7407
AE-88-WQ63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.355123
MB-46-BT89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291913
PSMA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02527
MM160113	DepMap CRISPR Gene Dependency	1.0	2.91641
Breast - Mammary Tissue	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.43568
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.41806
MARCHF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54987
IE-80-DC24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221167
CTSL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33826
CRCGN017_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.25063
BRD-K26122955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40695
BRD-K80940089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21366
BB-93-VT73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.842185
BRD-K42449328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18676
TF-04-RX73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.72937
AC-24-QG69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20658
BRD-K47762331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56559
Supramolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
GSE60691_2_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SKAP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00552735
GSE213153_1_v_0_ulixertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-72-RI24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.732365
PF-84-RH50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.663135
5216_MRPL34_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.555178
GSE48812_4_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
4152_INTS7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.522111
GSE182680,GSE182683_10_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Trophoblast giant cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.792
BRD-K23405268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05452
Cytokine Signaling in Immune system	Reactome Pathways 2024	1.0	null
MCF7_Momelotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138473
CRCGN009_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.10736
CAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00267741
LILRP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00819092
BRD-K58277621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38291
7117_RARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.603533
Bloom syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.637
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.594724
BRD-K86371068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45528
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
IA-38-XE73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272008
AC-86-KF37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.539207
BRD-K72661036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21548
XC-81-LR46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.530956
BD-38-GC64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207435
BC-75-FA82_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22848
ERRFI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00671138
Replisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.401
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.95971
DA-10-HD17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248889
GPR119	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00429
AD-72-RI24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.597477
DC-17-ZB19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265375
BRD-K56778317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69104
KELLY	DepMap CRISPR Gene Dependency	1.0	2.11785
BRD-K33217094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61441
ICAM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00538302
GSE176008_7_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RL cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.26
GSE182680,GSE182683_7_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.292
4693_LSM4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.54593
GSE48812_3_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-8.73381
ZB-16-BR73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.47004
GSE81796_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-49-BD04_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210103
BRD-K42828928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19953
PLIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57754
AC-50-FR41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.21962
BRD-K70895130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05609
CRCGN015_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.59298
BRD-K19523037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33022
Pollen mother cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.512
AC-33-YJ09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.273289
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208225
BRD-A52749901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23992
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0607
GSE234043_0_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169152_3_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PLEKHM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00836929
Extravillous cytotrophoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.898
BRD-K89638177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20772
BRD-A01759464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53559
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Baboon_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
DC-47-KV62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.657638
CRCGN011_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1778
FD-59-TC81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.374528
SMSCTR	DepMap CRISPR Gene Dependency	1.0	3.13835
bub1-bub3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.15
IMR32	DepMap CRISPR Gene Dependency	1.0	2.10286
CRCGN010_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.30272
GSE216043_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and neck squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.015
BRD-K82194980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01247
double-stranded DNA binding	GO Molecular Function Annotations 2023	1.0	null
4154_INTS9_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.05368
6550_POLR2I_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.613015
CRCGN017_MCF10A.TP53.M_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.11594
BRD-K11700411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48173
AA-62-OC45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.584008
TPSAB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0113648
BRD-K77221872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04025
DE-99-OT37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259789
CTCF-33576154-HUMAN-PERIGASTRICLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.343893
A549_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174324
GSE205540_2_v_1_phloridzin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GA-87-BR97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.637442
GSE193258,GSE193259_9_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pericentric heterochromatin	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.403
ID-26-HX79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.385874
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.39
BRD-K77814566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44861
BC-11-LL59_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278535
CRCGN009_HEPG2_24H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4603
AA-85-LB25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.564437
RUSC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07878
GSE206516,GSE206518_0_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12513837-41588_2025_2336_MOESM4_ESM.xlsx-Supplementary_Table_1-Supplementary_Table_1_List_of_AR-only_and_p300_AR-shared_enhancer_regulated_genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.39
PD-94-WO47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.274777
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN009_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.02051
ED-02-CL76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.389712
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-12.2392
BRD-K43479153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01965
8921_TIMM23B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.679274
RB-55-KL42_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.390336
1408_CDC5L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.598899
AF-99-HA02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255415
2460_ECD_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.522559
DNA repair pathways full network	WikiPathways Pathways 2024	1.0	null
CRCGN017_MCF10A.WT.HP_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.01965
NCIH2004RT	DepMap CRISPR Gene Dependency	1.0	2.48511
FA-36-VA24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.068
CRCGN013_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.11833
BRD-K75985122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02037
BRD-K28952606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27
C4I	DepMap CRISPR Gene Dependency	1.0	2.24601
FA-92-JL46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269526
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.23385
PMC12205070-41467_2025_61222_MOESM5_ESM.xlsx-DE_markers_TAL1_scenic_reductio-gene_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
DNA ligase IV complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.249
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.26912
FD-88-CF51_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237633
BRD-K56075657	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38058
BRD-K32451879	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88341
3554_GSPT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.638995
CRCGN010_HEPG2_24H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.33807
JC-02-ZR15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.594984
3980_HSPA9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.781602
AA-09-HG96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.429843
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.8213
GC-46-CA74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.56469
MCF7_BMS-911543_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163681
BRD-K55895855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.403
IP6K3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00583854
MBD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00438411
BRD-K78809123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07118
A549_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177968
BRD-K79887735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01493
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.80725
DB-63-TM61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.410867
AD-66-NO48_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227496
BRD-K45398957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.44124
Transcription factor TFIIIC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.524
C8166	DepMap CRISPR Gene Dependency	1.0	2.45166
BRD-K24308170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41033
AE-07-IZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.13926
496100305_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.26215
CD1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00860648
CRCGN014_HEPG2_3H:E01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.074
2537_EIF2B3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.535867
BRD-K65245206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29184
LD-14-PB06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.08417
Chromatin	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE242083,GSE242098_2_v_5_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AE-88-WQ63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.48455
BRD-K11687039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19981
GSE227592_2_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
PKD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0061533
BRD-K24965236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27647
LC-12-VN85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.406536
AA-23-FM46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.32238
Chelate leg	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.538
KA-63-FH23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.26015
CRCGN012_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31075
MCF7_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140447
GSE151782_1_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146045_1_v_0_lama3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201110_0_v_1_sirt4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165682_4_v_3_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CYTH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00410902
NA-16-OJ70_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.585416
AC-37-OZ52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240053
MCF7_PD98059_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140147
GSE148692,GSE148695_5_v_6_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
d2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.313
AC-83-LN99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.333539
XPOT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00450883
VA-06-DB75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.64123
BRD-K87340219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25608
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K25305749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01279
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.90475
KPNYS	DepMap CRISPR Gene Dependency	1.0	2.10057
RPL8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00667393
GE-58-RW27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.654506
BRD-K77177732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58432
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.41589
VAV1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00639729
XB-53-OZ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.26601
VNN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00777822
STOML1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7947
SKNMM	DepMap CRISPR Gene Dependency	1.0	2.44562
GSE239578_1_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.52167
EF-22-PB37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228625
BRD-K53647853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35838
AA-62-HP31_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23316
BRD-K20661169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.49552
BRD-K45508763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10473
BRD-K98513899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85552
PMEPA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00754631
4540_LDB1_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.527539
8231_SNRPE_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.553496
BRD-K31354456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26462
IA-97-VE31_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230128
GSE171269_1_v_3_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.49732
BRD-K42654859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76845
RARA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0056155
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-11.7272
BRD-K93459372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34045
AA-18-GQ83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.55068
CF-24-KQ98_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200887
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.38888
BA-40-IU73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281365
Fanconi Anemia	DisGeNET Gene-Disease Associations	1.0	null
BC-32-DI69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259269
RC-18-AD40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.321846
DA-15-PU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286748
Breast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
3654_HBS1L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.665119
BRD-K63134971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6875
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.55352
496100648_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.18618
NUDT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15021
ZNF528	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0015
GSE114284_1_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K60437668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47183
LE-94-HL75_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.278083
7645_SAMM50_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.504459
Chromosome Maintenance	Reactome Pathways 2024	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.750718
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PB-09-OE00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.308913
PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12464728-HSR2-8-e71283-s003.docx-29-1000_ZFP41_1_ZFP41	Rummagene Transcription Factor Associations 2026	1.0	null
PKR-mediated signaling	Reactome Pathways 2024	1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.4632
PMC5651844-41467_2017_1173_MOESM4_ESM.xlsx-sheet_1-Supplementary_Data_1_Down_regulated_genes_in_YEATS2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K66032509	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21072
BRD-K88820027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09371
GSE161800_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.66395
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.643255
SORL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540762
BRD-K13534347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4657
6981_QARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.525159
NE-37-JX51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209042
BRD-K70643771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13747
ACLY	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00604649
ZNF708	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.8139
GSE110178_4_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE181003_3_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12769604-13402_2025_1147_MOESM6_ESM.xlsx-Table_S4_3_Venn-Scissor_AND_Tumor_NOT_Prognosis_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K95810752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14509
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.455484
MD-17-VD78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.05827
EIF2S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-5.79818
CRCGN014_HEPG2_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.84148
DA-86-GO43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.306499
GSE205730,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8252_SNX29_ENST00000306030.3,ENST00000323433.4	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.710616
NCCMPNST1C1	DepMap CRISPR Gene Dependency	1.0	2.3004
PMC7339546-12915_2020_793_MOESM2_ESM.xlsx-Table_S12-Table_S12_common_twin_genes_in_one_HMR_core_region_between_cattle_and_human_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
MAP1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00502161
NB17	DepMap CRISPR Gene Dependency	1.0	2.41727
CD-16-KY17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239289
GSE126463_6_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.99312
BRD-K97526959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73116
BRD-A07407288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24576
Antiviral mechanism by IFN-stimulated genes	Reactome Pathways 2024	1.0	null
6150_PDAP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.545586
CRCGN016_MCF10A.TP53.M_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16487
BRD-K92291448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61175
7814_SETD1A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.521114
YF-00-IN39_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.34358
CRCGN015_MCF10A.TP53.M_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.42198
YB-79-DM48_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.29196
C1QB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00507352
GSE180982_1_v_0_mlst8_human	RummaGEO Gene Perturbation Signatures	1.0	null
ASCL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	79.0123
BRD-K35935439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0235
2538_EIF2B4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.556204
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20937
GSE147876,GSE147877_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
preweaning lethality, incomplete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
GSE110178_1_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE110178_1_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NH12	DepMap CRISPR Gene Dependency	1.0	2.03621
GSE182680,GSE182683_7_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.216
BRD-K31889353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08611
Condensed nuclear chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.979
BRD-K25103635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13158
BRD-K01734019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01754
GSE149760_0_v_5_elof1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.67445
GSE200352_11_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.520934
GSE101537_1_v_3_neurog3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04473
BACE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32233
SPI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00723451
CRCGN015_HEPG2_48H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.84322
DNA repair	GO Biological Process Annotations 2023	1.0	null
Condensed chromosome, centromeric region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.647
Fanconi Anemia Pathway	Reactome Pathways 2024	1.0	null
BRD-K61022988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.64007
SAP30	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00519144
BRD-K66896657	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8772
BA-86-AL61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.830128
GF-72-OO48_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206736
BRD-K43295075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91137
BRD-K04378630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94142
GSE82032_3_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K61621900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01207
ED-27-OE11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247653
BRD-K75038426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01103
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.4689
GSE186440,GSE186443_0_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193258,GSE193259_2_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7839_SF3B5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.527892
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.683256
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8064
GSE148692,GSE148695_5_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2164
RHEBP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00450162
BRD-K83190598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0774
AB-18-YN11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.32381
RPL15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4285
BRD-K50094173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93021
Cell Cycle	Reactome Pathways 2024	1.0	null
resolution of meiotic recombination intermediates	GO Biological Process Annotations 2025	1.0	null
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.297
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K98355012	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24348
GSE229973_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A69196860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.47917
BRD-K25954314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05043
BRD-K63500288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07793
CD-20-GE75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.696433
DBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47774
R3HCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1258
BC-61-ZY95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.43495
BRD-K26233698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31214
AD-45-YB25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.399193
Immune System	Reactome Pathways 2024	1.0	null
OB-17-DQ74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.30326
BRD-K94921631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47694
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K80895505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6204
Gametophore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.721
PMC10055234-media-3.xlsx-ZCCHC17_KD_DSGs_637-Unnamed_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9634663-DataSheet10.xlsx-K562-MYC-AID_RNA-Seq_1326_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
YA-44-LW45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.944477
CRCGN013_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.8972
TE-87-FM14_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285583
PMC8384902-mmc5.xlsx-H2107_PROX1_ChIP-Symbol_PROX1	Rummagene Transcription Factor Associations 2026	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.211
CRCGN017_MCF10A.TP53.M_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.77285
CRCGN017_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7976
MAP3K14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54508
DD-95-TY80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214062
BRD-K43025624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62522
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219687
HA-53-FL63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.372211
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.378221
Site of double-strand break	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.287
OB-20-LP90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.793254
CRCGN012_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.58249
AC-36-FB52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.447424
CRCGN009_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.10856
GSE133516_0_v_1_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8002
BF-97-LS55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.33735
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CENP-A containing nucleosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.377
BB-58-LW82_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226869
Oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE213588_9_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-68-OJ16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.66281
GSE169356_0_v_5_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.639123
1410_CDC73_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.657673
DE-69-QQ25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203972
BRD-K78762661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03902
TP53BP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00670523
BRD-K30964193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06548
MEN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16424
SNU475	DepMap CRISPR Gene Dependency	1.0	2.38072
TB-55-WY28_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.315939
AA-62-JP26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.531884
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.290131
6460_PLRG1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.798632
BRD-K01225799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45708
AD-45-YB25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.335775
CRCGN015_HEPG2_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6724
Mitotic spindle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.555
GSE110178_5_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.2501
AA-58-FJ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.35211
NUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08049
BRD-K19734887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.223
PMC9437808-mmc3.xlsx-IPA_Upstream_regulators-IPA_Upstream_regulator_analysis_Up_regulated_genes_following_LPS_treatment_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE138001_5_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LF-64-NB46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230428
BRD-K67183010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00864
PMC9090837-41467_2022_30207_MOESM4_ESM.xlsx-hTSC_essential_TFs-AHCTF1_AHCTF1	Rummagene Transcription Factor Associations 2026	1.0	null
FD-88-CF51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.549414
BST1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00517341
RAMP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00588273
BRD-K52441396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20319
CRCGN008_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02945
DE-58-OW37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.845599
VC-79-JG59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231498
LE-40-JW92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.44799
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.87192
DD-43-WW40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231244
BRD-K23166347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27869
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.2931
HF-79-EC41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.458012
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.856308
MCM8-MCM9 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.627
8599_SUPT6H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.683179
SIGLEC10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00879721
CRCGN015_MCF10A.TP53.M_24H:I04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.93129
Fanconi anemia complementation group I	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.522
BRD-K37929710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54015
CRCGN015_MCF10A_48H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.94835
BB-42-FF52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.2742
Meiotic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.935
CRCGN012_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.96892
GSE195559_8_v_5_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
DD-71-LY65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.3227
HF-91-IU60_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237605
496100359_PCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-4.08553
CRCGN017_MCF10A.WT.HP_24H:B16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5432
A549_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141914
RD-57-WQ44_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215626
GB-06-BA49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.381351
HA-38-ML65_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219957
TNFSF11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00558126
AC-92-HS43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249894
PMC12240782-Table3.xlsx-Sheet1-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160817_3_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128076_2_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.569826
Mitotic spindle assembly checkpoint MAD1-MAD2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.97
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.9054
Delta DNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.065
LF-64-NB46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.48584
CRCGN015_HEPG2_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.05463
NC-52-AG88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.77391
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K17133642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34267
BRD-K82671459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13438
DF-00-DK69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.08127
GSE180641_0_v_1_zfp503_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-9.51599
Epsilon DNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.779
OE-78-TD20_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.348015
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
KAT6B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0037243
PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-SUPPLEMENTARY_TABLE_12_Bulk_RNA-seq_results_of_invasive_fractions_from_GBM43_CTH_knockdwn_vs_GBM43_control_cells_invading_3D_hydrogels_AR	Rummagene Transcription Factor Associations 2026	1.0	null
DE-00-JU18_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201686
GSE114258_1_v_0_foxk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Monopolin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.395
CRCGN012_HEPG2_24H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.59405
CRCGN017_MCF10A.TP53.M_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18432
BRD-K51253991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23052
BRD-K14868348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79278
GSE235066_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.48961
BC-87-PJ84_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.372592
6480_PMPCB_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.597989
BRD-K80198069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34144
CRCGN017_MCF10A.WT.HP_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.13
BRD-K68574010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02101
AC-57-ZF49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232488
496100473_TCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.60624
CRCGN017_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.07005
BRD-K94913508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12976
CRCGN009_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.93513
BRD-K09711841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51665
DE-48-FF01_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227632
PMC10149505-41392_2023_1393_MOESM2_ESM.xlsx-CPCMR-Hugo_Symbol_MEIS2	Rummagene Transcription Factor Associations 2026	1.0	null
DNA gyrase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.899
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	85.0168
CRCGN017_MCF10A.TP53.M_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4187
CRCGN017_MCF10A.TP53.M_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44999
CRCGN017_MCF10A.WT.HP_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13932
CRCGN017_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0928
Ndc80 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.513
CREST syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.505
NB-89-OV56_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237021
CC-93-RP38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240243
GSE103372_0_v_3_smad1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TRMT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92502
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.287438
CRCGN015_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.87049
LC-57-RH78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.393609
BRD-K97170716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61898
CRCGN017_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03005
BC-14-CG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263994
BRD-K43051162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11565
BRD-K72707702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21556
GSE142430_2_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K93693615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23255
KA-75-LP02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.06582
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:J20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.83595
BRD-K63624341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82746
FC-35-BX82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.514218
GA-09-TM90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.863077
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.355
GE-29-ZM45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248956
BRD-K11428617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85885
ZNF45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00878
CA-73-BW50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.331037
GSE220520_3_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE200352_10_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K68562280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35859
CRCGN016_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22276
KD-36-KT24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.332628
GSE167218_1_v_0_hoxd12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PC-63-CH43_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242115
GSE117042_1_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K47108422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21319
deferoxamine-mesylate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34129
GSE168401_2_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.543946
BRD-K85887470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63481
BRD-K51411441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85212
Pancreatic Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.236
PMC9843885-40478_2023_1507_MOESM6_ESM.xlsx-CIC-OE_TS603-Unnamed_1_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF574	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.7222
GSE147876,GSE147877_4_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MD-86-UW46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.344222
CRCGN015_MCF10A.TP53.M_24H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24215
BCL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00642334
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.17901
BRD-A94046266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34801
IE-75-ZC91_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212501
SPTBN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0071312
KE-37-MN32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.12095
Spindle pole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.297
BRD-K61034310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15668
EF-22-PB37_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.373454
d5	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.391
8288_SOX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.717492
BRD-K86586698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00865
GSE134375_6_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BC-15-EL49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.88126
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.503808
BRD-K32037893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18007
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.290533
BC-14-CG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.51705
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4997
CRCGN015_MCF10A.WT.HP_24H:C04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3832
BRD-K44177822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62578
JA-63-WB39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.08248
AE-54-BN96_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243855
CRCGN012_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.91758
KML1	DepMap CRISPR Gene Dependency	1.0	2.46019
BRD-K52665916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03291
BB-86-UL91_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.382304
2367_DPY30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.923987
BRD-K61440521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56585
PABPC1L2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95567
GSE124410_6_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2539_EIF2B5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.559525
CRYZ	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00572917
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.311
GSE175787_11_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.9061
FACT complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.124
S0-EE-Y9S3_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220523
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.399
DD-26-VR55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271381
BRD-K53662389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58856
BD-33-HT38_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258212
AC-30-XU83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.08963
GSE126463_1_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K66453893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47057
BRD-K11168234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31791
BRD-K89952634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14616
NCIH446	DepMap CRISPR Gene Dependency	1.0	2.0052
COL4A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564701
CRCGN015_MCF10A.TP53.M_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.33732
BRD-K54272776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00441
Esophagus - Mucosa	GTEx Tissue Gene Expression Profiles 2023	1.0	1.54648
BRD-K38947493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54363
NCIH2887	DepMap CRISPR Gene Dependency	1.0	2.4499
MITF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00701644
496100639_TCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.9969
8155_SMC1A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.644444
GSE135030_8_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K90408478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02098
BE-05-KR03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219298
CRCGN016_MCF10A.TP53.M_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.33695
DA-15-PU65_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.430167
KLHL34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5481
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MIS12/MIND type complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.444
BRD-K11442063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44044
LC-96-WR85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.277996
BRD-K65888165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12116
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HE-34-ZC14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.350248
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.81572
UF-06-JB00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.73618
2537_EIF2B3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.757797
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CB-06-FE89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244873
BB-23-PM31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.44
JE-04-LS32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.340199
BRD-K02311826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72466
FB-60-JQ38_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30889
GPKOW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03336
YF-64-PQ11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270285
TADA2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00736451
DC-23-UM36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.34845
FA-63-WI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.14549
BRD-K23701005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27604
CRCGN016_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.10287
TSPAN10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00649797
BRD-K90999585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0971
BRD-K31010207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31697
5-8F cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.611
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	146.949
GSE125007,GSE125008_10_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Chromosome 17p13.3 duplication syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
3632_HARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.605492
BRD-K77041516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06404
DA-15-PU65_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.425617
SERPINF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00576634
Aplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.7
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.696912
BRD-K64483847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30993
IA-48-KI53_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.455391
DB-73-BC12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292291
BRD-K61189585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15024
H2AC12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00437291
PSS131R	DepMap CRISPR Gene Dependency	1.0	2.71667
KD-86-AJ75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227601
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.83904
BRD-K72821236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28492
GSE102870_3_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7112
CRCGN015_MCF10A.WT.HP_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11035
AA-62-HP31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.497114
Site of DNA damage	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.355
BRD-K50931403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.43091
TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3361
GD-82-CS38_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.533542
BB-11-JI42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.630896
CTCFL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.0444
BTN3A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00556218
GSE218819_2_v_1_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.08385
BRD-K54836449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30396
9837_WDR70_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.575045
Xeroderma pigmentosum variant type	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.044
SUM1315MO2	DepMap CRISPR Gene Dependency	1.0	2.16501
BRD-K90821428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75889
PMC8816731-41388_2021_2128_MOESM8_ESM.xlsx-TF_Downregulated_by_SNAIL1-Unnamed_1_SNAI1	Rummagene Transcription Factor Associations 2026	1.0	null
ND-20-AS37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259569
ADAM28	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00620092
LO68	DepMap CRISPR Gene Dependency	1.0	2.15853
XA-12-UL84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.09268
CRCGN016_MCF10A.WT.HP_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7106
GE-40-GQ38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.98225
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.29782
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
ORAI3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00623773
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0783
8205_SNAPC1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.530535
T/G HA-VSMC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.817
PTGDR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0044737
GSE171175,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.20843
NMRK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00543457
HF-39-BC66_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203711
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Baboon_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3075
RB-55-KL42_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242643
FF-34-KW62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.45761
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.942
DE-73-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.24616
Chromosomal region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.417
BRD-K76065617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03796
CRCGN016_MCF10A.TP53.M_24H:P11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.37882
AB-09-EA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.3968
BA-39-HG26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.43062
ED-92-AL11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226536
PRKDC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54676
HEXA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0065608
SMARCA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00611407
Chromosomal region	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
BRD-K44139682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04615
nucleus	GO Cellular Component Annotations 2025	1.0	null
3950_HSD17B12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.5131
10569_ZNF705B_ENST00000443676.1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.501053
BRD-K37866276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16296
AF-83-BX08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302723
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
8232_SNRPF_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.707612
BRD-K93675803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21853
GSE227592_6_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
7332_RNASEK_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.583785
BRD-K77108448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13012
CCLFPEDS0003T	DepMap CRISPR Gene Dependency	1.0	2.47492
Fanconi anaemia nuclear complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.96
VC-19-YG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.582442
BRD-K49443464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19614
ODC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00609537
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.134
BRD-K45845217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43618
BRD-K26508889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81352
DC-45-WU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229636
GSE157383_6_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.70747
EC-98-KI28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.113
DC-23-UM36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.09293
10136_ZMAT2_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.732244
GSE148321,GSE169423_2_v_1_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11511861-41420_2024_2216_MOESM2_ESM.xlsx-siTAZ_myc_bound-MYC_targets_from_chipseq_atlas_at_least_2_chip-seqs_over_4_in_A459_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE143462_0_v_1_omipalisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.990869
DRD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00562883
BRD-A78085235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28218
AATF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42402
BRD-K63919349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04465
BRD-K60728944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67085
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.97461
BRD-K97617600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03608
BRD-K32444429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57916
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.553
BRD-K52424224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87338
Swi5-Sfr1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.82
BRD-A80010944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8974
PSG3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00726009
AE-04-SN76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.77886
BRD-K40621788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64993
TBX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00463164
4942_MED1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.534307
BRD-K68980973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39327
BRD-K82112239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32886
BRD-K37176385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05784
BRD-K58017833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68949
BRD-K48699175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7738
OC-10-FB51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207742
chr17_82013189_C_T_b38	GTEx eQTL 2025	1.0	1.13205
BRD-K40697889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65853
4154_INTS9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.71702
SNAI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7439
BRD-K33287655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02779
Rad51B-Rad51C-Rad51D-XRCC2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.127
KC-45-DZ26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225182
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE62843,GSE64371_2_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K83341545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27036
GSE134029_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-11-BO01_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230994
TB-55-WY28_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229462
496100319_HIP_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.10059
1298_CCDC84_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.588045
A549_Prednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167638
NOC4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15339
MutLalpha complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.709
DCUN1D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00681895
GSE193541_0_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_8_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19318
chromosome, centromeric region	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
BRD-K50600207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.04117
BRD-K94344573	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39486
GA-47-MH68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.94383
BRD-K40724407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03479
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128076_1_v_3_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6613
AC-30-XU83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20407
GSE231648_4_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IB-14-YP50_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205271
BB-77-QQ71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203053
SLC66A1L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00522624
CRCGN014_HEPG2_3H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19727
GSE146982_7_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YA-85-VH07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.21279
HSDL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02061
2120_DDX41_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.51065
CRCGN014_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4358
FA-95-HA77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233688
CRCGN017_MCF10A.WT.HP_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.19715
HA-22-CY42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.15865
IF-92-OK68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.429562
BF-22-EP86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.491593
DE-98-FC24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.15032
SLFN14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00721478
FF-28-ES17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.96187
6276_PHB_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.803209
10029_ZC3H8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.565145
CAL78	DepMap CRISPR Gene Dependency	1.0	2.61028
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.10695
DE-58-OW37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.365312
IB-87-ZR37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264208
BRD-K82394273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57091
ALOX12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00510841
CE-77-JB44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226259
PDK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00602926
BRD-K35860167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37945
ND-39-PO34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.524129
GSE148692,GSE148695_1_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BB-43-YQ76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.405088
SF-9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.341
Interferon Signaling	Reactome Pathways 2024	1.0	null
GSE210655_3_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Centriolar satellite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.648
4522_LARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.530229
GSE213228_4_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
YF-64-PQ11_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267754
OC-41-DF58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243184
CRCGN015_HEPG2_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.63249
chromosome, centromeric region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.569
GSE164508_1_v_0_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE229973_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-85-ME82_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219723
CRCGN016_MCF10A.TP53.M_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.02815
PMC7932549__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GD-90-RA90_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266036
BRD-K73528610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16788
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.15455
GSE116810_5_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K84235037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75652
MCF7_AG-490_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150082
CRCGN015_MCF10A_48H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.2658
AE-73-KX58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.38212
CRCGN015_HEPG2_48H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08931
LD-22-SA99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.356376
XC-12-SL04_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.343391
MCF7_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186569
KCNH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00708269
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
ABI3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00615825
GSE146982_7_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BB-11-JI42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.905785
Mitotic checkpoint complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.668
GSE104022_1_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.89117
GSE158834_10_v_9_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_PFI-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162751
CRCGN017_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2945
CRCGN017_MCF10A.TP53.M_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6759
GSE108614,GSE108615_0_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MutSbeta complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.142
BRD-K26738018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92331
AD-66-NO48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.814516
KIJK	DepMap CRISPR Gene Dependency	1.0	2.32327
K562_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191495
3336_GEMIN5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.526586
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.7884
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SD-69-QA40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291907
4950_MED27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.754332
GSE202434,GSE202438_9_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Karyomegalic interstitial nephritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
QC-12-DW06_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.377837
GSE89767_7_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9857
3504_GPN3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.543725
SLC12A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48376
CRCGN017_MCF10A.WT.HP_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.5038
CEP170	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00905076
BRD-K24514314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29469
BRD-K30105551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5223
Seminal vesicle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN016_MCF10A.WT.HP_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17133
KDM4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00433131
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-15.8788
SYNGR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00977111
CRCGN015_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.28434
IE-28-SY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.305154
FC-56-ZH16_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224722
BE-57-VZ17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.507145
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.42312
BRD-K20051655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57393
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Nearest_Ensembl_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
UF-85-NE30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.627817
MF-04-HB41_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224452
GB-73-QS80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.85895
BRD-K51385533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59384
HC-01-FD24_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279977
BRD-K76889263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25385
EA-09-HM95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.317829
MASTL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00695188
PSME4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3486
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K74817844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.22064
CB-99-OG76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.341021
GSE111247_0_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.90595
CRCGN015_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4215
GSE224311_3_v_1_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
LLGL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41889
GSE118077_7_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cockayne syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.292
AA-03-QM41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.614241
KIR3DL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00622904
Holliday junction resolvase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.252
replication fork processing	GO Biological Process Annotations 2023	1.0	null
BRD-K49042040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35857
BRD-K85474153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67844
BRD-K23975481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47831
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17792
CBX4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00489053
BC-20-WA90_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.557089
AE-39-DG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.556288
PMC12455829-11658_2025_792_MOESM8_ESM.xlsx-2_DDIT3_IP_vs_BRG1_IP-Unnamed_2_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10154349-41418_2023_1142_MOESM6_ESM.xlsx-Sheet1-Supplementary_data_3_Genes_positively_correlated_with_HOXC13-AS_in_skin_granular_cells_correlation_coefficients_cor_0_FDR_0_05_HOXC13	Rummagene Transcription Factor Associations 2026	1.0	null
GSE155162,GSE155169_1_v_0_buparlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
4957_MED7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.557978
GSE162087_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RXRA::VDR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.7
BRD-K32146668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17313
GA-81-DL34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.864485
GSE203158_1_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ETV5::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.3739
CRCGN016_MCF10A.WT.HP_24H:P16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24656
496100321_HIP_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.15535
AE-85-LR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.52441
7585_RTF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.759678
HD-89-HC56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244611
IRF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00144
RD-92-QT24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.541888
JD-87-MR82_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.284434
AA-86-YY62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.863201
CRCGN013_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.4876
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.640109
AE-66-YB82_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20066
PMC8387919-mmc2.xlsx-ST9_NEUROG3_bound_TF_genes-Supplemental_Table_9_NEUROG3_bound_TFs_genes_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE190384,GSE190386_3_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182854_2_v_0_sirt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114284_1_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE172295_3_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE204811,GSE204813_1_v_3_trim29_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.19405
GSE159937_1_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE103372_1_v_2_smad1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2536_EIF2B2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.658621
GSE176008_8_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GB-94-XG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.845494
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-17.1884
BRD-K68683482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.30364
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7583
BB-77-QQ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.301607
KA-51-CQ55_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305615
GSE199606_1_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RD-57-WQ44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258341
NC-27-AD53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.449939
NARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0305
CRCGN016_MCF10A.WT.HP_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.47069
BC-54-ON71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.86821
CA-68-SW47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21651
BA-74-WG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.321093
Ovarian melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.119
SUZ12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00591006
PF-59-CY33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.85226
CENP-A recruiting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.985
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262634
CRCGN015_MCF10A.WT.HP_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14878
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CD177	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00744618
MCF7_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169544
RH28	DepMap CRISPR Gene Dependency	1.0	2.65657
FA-10-SN61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.487013
OC-41-DF58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.282367
BD-38-QC39_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267758
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-14.3476
BRD-K12431811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.60146
MM386	DepMap CRISPR Gene Dependency	1.0	2.20142
CRCGN016_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.44909
BRD-K58028568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18674
CRCGN009_HEPG2_24H:M19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.87965
CRCGN015_HEPG2_48H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.92317
Normocytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.574
AE-14-NN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.353538
496100529_HIP_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.08961
BRD-K18117162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24876
JA-85-SW39_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.79188
GSE213588_10_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K45642123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02908
BRD-K28950508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01812
CRCGN017_MCF10A.WT.HP_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.40965
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.92717
CRCGN010_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.37385
BICR16	DepMap CRISPR Gene Dependency	1.0	2.09382
PSMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16707
BRD-K92701606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18539
BRD-K03848296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.37706
BRCA1-BARD1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.053
BRD-K61796560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30513
CRCGN009_HEPG2_24H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0313
CRCGN008_HEPG2_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.53475
AE-13-CX28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.3534
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K17940097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05173
PMC10915192-ab-23-0304-Supplementary-Table-S6.pdf-6-TEF_TEF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171269_1_v_4_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MD-03-NA01_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210617
PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE203158_5_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DB-41-SH04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.278239
A549_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183227
CRCGN014_HEPG2_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29088
GSE172295_1_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K46413323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68389
JD-87-MR82_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227193
JD-62-TK68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250664
ID-70-SM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.773536
S0-EE-Y97N_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.53744
Conventional (Clear Cell) Renal Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K58248556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81003
NA-16-OJ70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234875
CRCGN016_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.04337
BRD-K50942788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13063
CRCGN015_MCF10A_48H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7114
NTERA2CLD1	DepMap CRISPR Gene Dependency	1.0	2.23782
7657_SARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.864177
BRD-K26459891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61434
SD-69-QA40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.383268
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K55453160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10957
ZD-18-MI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.295782
CRCGN015_MCF10A.WT.HP_24H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2469
BRD-K41044903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96393
CRCGN017_MCF10A.WT.HP_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.41405
GSE109913_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DA-27-BW20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261114
BRD-K38966099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96332
PMC5651844-41467_2017_1173_MOESM5_ESM.xlsx-Down_genes_shY2-1-Supplementary_Data_1_Down_regulated_genes_in_ShY2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
NFYA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9863
CRCGN013_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.21574
GSE135030_3_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLHL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78809
preweaning lethality, incomplete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
GSE171292_6_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GB-73-QS80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.331389
CRCGN012_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.88843
LE-01-MT37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.491777
MTNR1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00456683
JC-96-ID26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.363496
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.28447
4939_MED17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.60358
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
LOXL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20025
BRD-K44244207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39069
CRCGN011_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.4251
CRCGN009_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00878
CRCGN008_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.36705
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.218
AA-11-RO46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257021
BRD-K39592958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54707
BRD-K75440064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56132
GSE139239_2_v_6_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SCS214	DepMap CRISPR Gene Dependency	1.0	2.20265
AC-50-FR41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.00815
MCF7_Streptozotocin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135211
Specific developmental disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.215
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.41798
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.671422
NGP	DepMap CRISPR Gene Dependency	1.0	2.63781
CRCGN013_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19561
BC-61-ZY95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276345
BD-96-HO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.54467
CRCGN017_MCF10A.TP53.M_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.8026
BRD-K76329122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36525
BRD-K72467884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21866
DSCAM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00745898
GSE63048_11_v_8_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K73795883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34912
NPC1L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00445875
double-stranded DNA binding	GO Molecular Function Annotations 2025	1.0	null
Anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.295
CBF3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.38
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.29347
TD-17-NF32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.507466
HE-99-KP87_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237298
JB-75-NC66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.61496
HC-83-TS50_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.392895
BA-31-KY85_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204889
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.605813
7166_RBM25_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.913912
BRD-K99581286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.40158
Endodeoxyribonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.27
GSE93309_1_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POU6F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59553
GSE161825_1_v_0_tipranavir_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE200673,GSE200691_1_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-86-ES28_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.720926
4149_INTS4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.536391
BRD-K72666100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13554
BRD-K94962273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30844
CE-72-GF32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.377287
NC-11-BC71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244431
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K14359942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46579
CC-31-VS31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.719474
GSE130246_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.331
1441_CDK7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.500695
GSE151782_2_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE231745_1_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.74752
BF-10-IO69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265504
A549_AT9283_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0110915
8426_SRRT_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.708323
IA-48-KI53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.607888
8271_SON_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.503616
CHLA90	DepMap CRISPR Gene Dependency	1.0	2.14218
BRD-K64183190	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39483
BRD-K96377358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48745
7607_RUVBL1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.591113
BRD-K99122228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04131
JF-30-FW92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.933774
PMC12205070-41467_2025_61222_MOESM5_ESM.xlsx-DE_markers_TAL1_scenic_reductio-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
POLK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7161
DE-11-PO61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276487
CRCGN008_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5777
DE-98-FC24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358297
CF-81-DS26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.668479
UPCISCC152	DepMap CRISPR Gene Dependency	1.0	2.33785
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-9.52674
WICH complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.97
BRD-A01717918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48738
BRD-K05222558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.3362
BRD-K58408512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71715
MF-04-HB41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208681
SC-02-RZ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.378216
DE-85-FR73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261916
IF-92-OK68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.275846
BRD-K93127164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97524
HF-35-HT37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245545
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.85711
BRD-K84048601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68002
BRD-K46562329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.59583
BRD-K56591923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61935
EC-82-LV30_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.87232
AC-31-SL44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.308859
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.585551
SCMCRM2	DepMap CRISPR Gene Dependency	1.0	2.71001
TC-25-NY68_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.27877
BRD-K90901488	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93
Attention deficit hyperactivity disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.215
Condensed chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.499
UBB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00402567
TEF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00805999
BRD-K62909525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48652
GSE239688_4_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CA-66-FY97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.89275
496100358_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.58489
GSE124410_2_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EC-41-PH99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.86421
CRCGN012_HEPG2_24H:J19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20645
BRD-K82324807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1672
RSF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.039
MCF7_SRT3025 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142173
BRD-K58194737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82433
Ovary epithelial cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.023
Lateral element	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.595
PMC10769395-media-2.xlsx-S2E_EF_Activated_genes-Ebegboni_et_al_Supplemental_Table_S2E_Decreased_expression_following_depletion_of_EWSR1_FLI1_TC-32_TC-71_and_A673_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN010_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.23985
RUNX1-27514584-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
EF-85-DA07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.618924
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.21524
AA-85-LB25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302552
BC-20-WA90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212379
BRD-K10358320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05594
BRD-K62682892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26922
BRD-K06958718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01322
DE-85-FR73_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239272
XCR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00480372
SAGA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.046
DNA-templated DNA replication maintenance of fidelity	GO Biological Process Annotations 2023	1.0	null
GATA3-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
DNA-templated DNA replication maintenance of fidelity	GO Biological Process Annotations 2025	1.0	null
LRIG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00687664
PARD6G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81697
176_AFG3L2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.597973
8923_TIMM44_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.662193
AD-30-OK99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285256
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.6317
BRD-K76508844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73682
GSE138019_3_v_2_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CENP-A containing chromatin	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.405
S0-EE-Y7IR_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.63099
DNA replication preinitiation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.573
CRCGN009_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.76108
CD300A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00575912
BRD-K63587749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67025
CF-56-LO98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.309865
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.30034
GSE81796_0_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.56108
CRCGN014_HEPG2_24H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.63432
GSE158834_10_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128076_2_v_3_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CB-82-PL01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.952268
GSE197555_0_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.81605
CAKI2	DepMap CRISPR Gene Dependency	1.0	2.16066
DC-28-NF06_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.332498
HF-35-HT37_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.464407
positive regulation of protein modification by small protein conjugation or removal	GO Biological Process Annotations 2023	1.0	null
GSE184884_7_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1451
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
5903_NUP93_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.11471
AC-84-QG99_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.43616
GSE175787_4_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hTERT-RPE1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.655
PMC7932549__F2	PFOCR Pathway Figure Associations 2023	1.0	null
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.950767
DE-81-OY65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203718
CRCGN012_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.58982
SHSY5Y	DepMap CRISPR Gene Dependency	1.0	2.31176
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.895
BRD-K11835238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18592
GSE195568_6_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
THAP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.5784
MutLgamma complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.872
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.82573
GSE138001_0_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NF-21-HQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.34323
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K10580455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32479
Zygotene cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.711
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.875185
EB-67-WB79_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262937
BRD-K82667180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45698
GSE200352_11_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.405023
BRD-K55459289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53988
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.246
AA-68-OJ16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.411451
GSE110178_5_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TICRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13905
GSE102467_1_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0114
ME-31-RM40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.419615
KC-67-HN97_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.317661
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YA-34-DT48_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21412
BRD-K81082554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11171
CRCGN012_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.97468
BRD-K40252598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29999
ID4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00908097
BRD-K42575648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26863
FA-72-JL16_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230127
FA-88-II68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.74851
AF-72-PP21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.536348
TENT4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00373576
EXTL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00556571
Bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K19103580	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15303
CRCGN013_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.48531
VD-88-MW70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.06737
JA-85-SW39_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307818
INO80-type complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.073
Deposition of new CENPA-containing nucleosomes at the centromere	Reactome Pathways 2024	1.0	null
CRCGN015_HEPG2_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0094
GSE206226_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K90872016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46254
AC-36-SY22_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.280045
GSE159678_6_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RAD54L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9535
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
CRCGN012_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44689
MEL270	DepMap CRISPR Gene Dependency	1.0	2.06818
4147_INTS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.782792
GF-05-GQ05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293054
BRD-K26291134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73494
KD-86-AJ75_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261517
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.859
WB-82-EL69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.820988
GSE87404,GSE87812_1_v_3_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CB-45-VH79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265295
YC-45-JD42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225635
AB-82-EP26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.366934
DNA packaging complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.912
Condensed chromosome, centromeric region	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.435
GSE201042_6_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE256181_1_v_0_etv2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AB-21-VE32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.3207
DHCR24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04419
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
6632_PPIL4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.532235
BRD-K10191318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43371
h4s	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.94
FC-22-VC55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.807459
BRD-K78818514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00699
GE-29-ZM45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.16386
FOXA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28968
JA-82-EV20_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22721
EC-72-RE74_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218725
CB-87-GT98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24634
Mitotic spindle microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.65
CELA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0067214
BRD-K97636821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14955
JE-22-JR20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.679851
CD-08-MF16_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228628
ITGB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10828
CD244	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00644862
M-07E cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.84
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.859758
6275_PHB2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.698443
CCNT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00780139
GSE146612_2_v_0_amiodarone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE121866_1_v_3_six4_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.29492
KRAS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00519587
BRD-K46599443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62836
BRD-K89811208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24719
BA-13-CC32_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267271
GA-94-MC54_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.753084
LAMP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00806276
CRCGN016_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.73991
9317_TRNAU1AP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.548339
BRD-K22474245	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58155
GSE216043_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100501_PCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.08088
BRD-K75164441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0473
GSE130246_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.7734
GSE62843,GSE64371_2_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CLIC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00712449
SB-94-ZA83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.68685
RPAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22411
BRD-K58670847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29002
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.419312
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.318
BRD-K14245433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05256
CRCGN012_HEPG2_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31585
CCN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00543052
CC-50-FK24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204284
496100347_PCx_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40179
CRCGN016_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1795
HB-92-XE24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.29918
GSE190384,GSE190386_2_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-40-KV26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272159
BRD-K37760996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04533
GSE139455_7_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE181003_3_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K32718856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54149
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260591
BRD-K70791360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80757
DB-40-GN91_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204786
NB-17-SQ59_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212854
GSE123022,GSE123030_8_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE183271_4_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
10029_ZC3H8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.71463
PNPT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00592702
TNFSF13B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00720076
ACVR2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1858
BRD-K89891928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24706
CRCGN017_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.9389
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.30101
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.78333
CRCGN008_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.168
ATP5F1D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00585787
BRD-K00920341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03737
BRD-K51515697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01715
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.078
Condensed chromosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
BRD-K67817697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02341
4153_INTS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.823538
BA-68-FJ41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.602938
BRD-K79753227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02366
YA-34-DT48_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.295682
CA-17-XB39_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227526
WB-82-EL69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.309376
CRCGN016_MCF10A.WT.HP_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7877
RPS6KB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42012
GSE147876,GSE147877_4_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.01878
CRCGN011_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09975
Developmental disorder of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.215
MCF7_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013887
Fanconi anemia complementation group D1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
BRD-K43390080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.103
PMC8384902-mmc5.xlsx-H128_ASCL1_ChIP-Symbol_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147876,GSE147877_2_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1661
GD-79-JJ38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225578
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.47762
BRD-K92524823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17627
BRD-K56739005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58147
CRCGN016_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.9993
GSE209911_0_v_1_ncstn_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206729_4_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186440,GSE186443_2_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BE-31-XV38_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.637382
BRD-K61287439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56164
CRCGN010_HEPG2_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0437
HSPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07862
LE-40-JW92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223025
496100370_PCx_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.22505
DA-01-GV68_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250465
BRD-K44548010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27729
CB-29-AX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208765
BRD-K28932860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57594
BRD-K48615268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28423
CRCGN016_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.53009
GSE154197_1_v_2_ints13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BE-73-KD75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.542372
BRD-K41700289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82537
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-87-EI21_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.431823
CRCGN012_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5466
GB-73-QS80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246082
Slx1-Slx4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.586
CRCGN014_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7281
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.756042
BRD-K92358687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42876
GSE126463_6_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
8598_SUPT5H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.698673
FF-86-NH56_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.38063
GSE147876,GSE147877_4_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9529122-pone.0274785.s002.xlsx-S1_Table-S1A_Table_Differentially_expressed_genes_in_HeyA8_overexpressin_ZNF521_vs_HeyA8_control_cells_ZNF521	Rummagene Transcription Factor Associations 2026	1.0	null
TTC24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540621
BRD-K04336022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51372
CTSK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00620059
AC-84-QG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.409098
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1395	DepMap CRISPR Gene Dependency	1.0	3.01803
GSE209598_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.94746
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224646
CRCGN009_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.75792
CSNK1E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06824
AA-62-JP26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.42753
BRD-K46458719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38334
CD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2397
BRD-K11089039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92434
GSE236454,GSE236456_0_v_1_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A80705936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40585
GSE168602,GSE168604_2_v_6_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239578_0_v_6_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HB-69-CT62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.378593
SCN2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00679866
GSE160817_5_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6605
Colon - Sigmoid	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.60601
SIMA	DepMap CRISPR Gene Dependency	1.0	2.98543
BRD-K63716942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06566
BRD-K10459972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86989
FA-80-DR66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.65632
GD-46-BU97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.35941
GSE70935_1_v_0_cyfip1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.52601
BRD-K77214780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.36172
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.99294
PF-59-CY33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.39257
A549_Curcumin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140813
DA-85-SU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267848
PMC10510228-13287_2023_3481_MOESM7_ESM.xlsx-DEGs-Differentially_expressed_genes_DEGs_in_bone_marrow-derived_MSCs_from_six_human_donors_cultured_at_high_confluency_MSC-HC_versus_low_confluency_MSC-LC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BHMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53566
MD-03-NA01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215155
BD-65-VV48_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203593
AA-85-LB25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285409
EDAR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00583588
FD-20-OG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.430125
LPIN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00772846
BRD-K36736230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33457
DE-29-MT22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231932
BRD-K90138084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91437
chromosome, centromeric core domain	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.405
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.02535
BRD-K41655405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09084
BRD-K87472370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38969
Meiotic spindle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.115
CTTNBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00597827
1578_CHML_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.520099
JB-75-NC66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273471
ID-00-IC14_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.11042
FE-64-KC49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297263
BRD-K11251396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30705
CRCGN017_MCF10A.TP53.M_24H:C02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23215
CRCGN009_HEPG2_24H:L07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9666
BB-79-AG41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.44163
AC-71-YF45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204575
GSE154767_4_v_3_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4696_LSM6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.593995
CRCGN015_MCF10A.WT.HP_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.02705
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K14375790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28026
PSMD14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37615
PC-87-OG75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221662
CRCGN017_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.71063
496100594_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05157
Meiotic cohesin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.548
BRD-K56055036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01134
K562_Sodium Phenylbutyrate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156363
Replication fork	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.188
BRD-K97410356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75117
BRD-K44950949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49257
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.4223
BRD-K59772014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60886
BRD-K75999096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66981
CRCGN009_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.61759
BRD-K02403042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38316
BRD-K47748211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59899
CRCGN017_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.435
DA-35-DU85_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.416724
BRD-K33503286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19736
GSE231648_1_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DE-62-FI29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.24631
NA-30-HS87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.418976
BRD-K36671227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10782
BE-42-IC00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.341228
Zeta DNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.41
CA-10-RU23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248771
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CENP-T-W-S-X complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.124
BC-09-JG96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.296506
resolution of meiotic recombination intermediates	GO Biological Process Annotations 2023	1.0	null
CD-35-BD44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.3156
GSE114992,GSE114993_0_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A36774080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31961
BRD-K92378241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25439
BRD-K37850190	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37662
CE-35-LA42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.648926
SP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	117.576
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-9.35824
DE-29-MT22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286253
6118_PCED1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.680763
BRD-K86845618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.25765
GD-90-RA90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242536
GSE121824,GSE121826_0_v_6_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015207
BRD-K25596713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.4361
BB-43-YQ76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245165
BRD-K52104866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14579
4691_LSM2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.51411
AD-99-SN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.357332
CRCGN015_MCF10A_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.65485
HT1197	DepMap CRISPR Gene Dependency	1.0	2.2001
6794_PRPF38A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.603912
BRD-K72488042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00002
HUO9	DepMap CRISPR Gene Dependency	1.0	2.05564
FB-91-BU05_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.535419
PMC8387919-mmc2.xlsx-ST9_NEUROG3_bound_TF_genes-Unnamed_2_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K40923781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76622
FA-47-IB34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.342491
BRD-K79965790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00904
PC-87-OG75_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231517
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K21201014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03957
GSE229973_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.67223
1971_CWC15_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.562603
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DT-40 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.495
8653_TAF12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.546864
GSE134375_3_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201042_6_v_7_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.59544
BRD-K17749779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94666
CRCGN014_HEPG2_24H:J15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.02475
NA-16-OJ70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.484871
GSE207135_1_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157894_2_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.391146
CRCGN017_MCF10A.WT.HP_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.50065
GSE88819_5_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K95323025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00438
4147_INTS2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.935317
ZNF93	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	129.798
U2-OS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.586
BRD-K63778487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41717
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nucleosome assembly	Reactome Pathways 2024	1.0	null
CRCGN014_HEPG2_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06714
13_AARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.569423
CYP27B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00728168
GSE143643,GSE143644_1_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
QE-00-EB96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305746
CRCGN014_HEPG2_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.43139
KHNYN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62657
CRCGN017_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.61442
chromosome, subtelomeric region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.201
BRD-K56590597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20367
Hyperglycemia	DisGeNET Gene-Disease Associations	1.0	null
GSE158834_7_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.15219
CRCGN012_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.68603
GSE210655_1_v_6_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BC-76-HY47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266162
SUPT20H	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00481468
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4272
Stomach	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.353
JF-39-BZ76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22793
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
6-10B cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.809
Inner kinetochore	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
KC-36-DK23_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.403066
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
oc314	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.98
AC-11-BO01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.32712
GNG11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00727482
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K63107801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48208
AC-98-UW57_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212217
BRD-K11457257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68985
AC-57-ZF49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.418116
RecQ family helicase-topoisomerase III complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.478
smc1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.962
PMC8872993-41380_2021_1274_MOESM4_ESM.xlsx-Table_S6-Supplementary_Table_S6_Differentially-Expressed_Genes_after_T-3_KD_in_hiPSC-derived_Astrocytes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CB-99-OG76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.281551
OC-10-FB51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250103
COV504	DepMap CRISPR Gene Dependency	1.0	2.21532
GSE165548_2_v_13_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K93457574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0309
Seckel syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.219
CRCGN016_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.47361
GSE114883_1_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213228_4_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SGK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00538771
KE-04-OV29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234701
BRD-K04695993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13576
GSE195663_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6757
Central nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.435
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.5412
CD69	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00734459
BE-04-AN21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.708473
GSE95302_1_v_4_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
EA-95-OQ30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239543
DE-97-IV02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.4032
FA-16-HR75_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281487
CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE110268_2_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K42804674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.37599
CB-24-FA25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.482965
BD-45-EU45_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292958
A-172 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.702
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
BD-69-XG81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211233
Head and neck cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
DC-22-HS83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263247
GSE221327_4_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:G19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.45242
WB-92-TT14_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246161
GF-35-IT27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.40557
BRD-K91459693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64537
BC-20-WA90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.328378
BRD-K11667893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54883
GSE160817_3_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-46-RY02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227986
MXD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00626625
BRD-K93785828	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35766
RC-52-AC88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.47153
DB-55-UX87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253714
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.73215
HC-76-HU27_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202479
BRD-K16954129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26501
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-12.6109
AB-97-BI36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223903
COASY	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00254722
YC-11-LU43_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213079
RB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76673
PMC4165364-13059_2014_406_MOESM5_ESM.xls-Supp_Dataset_1-SUPPLEMENTARY_DATASET_1_AML3_AzaC_SigDiff_1147_Note_to_reviewers_-_view_these_files_as_xls_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
RBE	DepMap CRISPR Gene Dependency	1.0	2.2962
ZHX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00660601
BRD-K09663164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48933
GSE111247_11_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BC-36-PL31_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299035
CRCGN014_HEPG2_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.19313
BA-95-YU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.43963
BRD-K05277255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41722
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235295
Chromocenter	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.001
CRCGN013_HEPG2_24H:I14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.82801
BRD-K92812209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10155
DD-96-DE39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.411367
GSE157262,GSE157268_3_v_0_ythdc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.412145
CRCGN015_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.25376
C2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00691778
BRD-K07588901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44264
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.41918
KA-75-LP02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.63936
SB-94-ZA83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.417105
9164_TOMM22_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.551351
BRD-K37912617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12332
IC-72-HR20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226985
CRCGN010_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11156
CRCGN017_MCF10A.WT.HP_24H:P11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1195
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.221
BRD-K67873600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24817
BRD-K90934902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66523
BA-95-YU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.24196
GSE183994_3_v_0_scml2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RNF123	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00626844
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.666038
CHD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00537367
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305983
BRD-K02159791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3194
EFNA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00489974
GSE218949_0_v_1_cep20_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100532_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.37975
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.8209
CRCGN016_MCF10A.WT.HP_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.91457
8594_SUPT16H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.502529
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
2561_EIF4A3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.5584
TICAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00476256
BRD-K72648699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.77548
PMC12281655-CPB-26-6-935_SD1.pdf-5-FEZF1_FEZF1	Rummagene Transcription Factor Associations 2026	1.0	null
NUS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56068
FE-49-VJ28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221209
GB-84-KP45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232476
CRCGN017_MCF10A.WT.HP_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0857
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GB-57-XV52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.24742
BC-09-XQ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.48407
786_BCAS2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.511355
OCILY19	DepMap CRISPR Gene Dependency	1.0	2.36566
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.309015
GSE202434,GSE202438_12_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K47998973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02334
ATP4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00589071
TRPV6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00598993
FD-79-TC61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.624702
JC-96-ID26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.310632
BRD-K27458941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.294
DC-22-OP01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.28844
HF-36-FK93_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.366425
8666_TAF5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.529657
BRD-K95740363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00222
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FE-29-XM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.599233
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.640053
GLB1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18149
BRD-K19435356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0772
EF-75-JG46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.561313
PIP5KL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00668989
BD-04-NG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.621538
CRCGN016_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.8736
PDPK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00794786
cefprozil	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47527
MB-53-WO35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.429049
CRB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00646123
BB-43-YQ76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.528844
BA-68-FJ41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.715559
GSE227592_0_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166315_1_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE181003_1_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE227592_8_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K01660763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15037
OB-65-AI50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.27662
FA-12-QB17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230401
GSE165647_5_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:N23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0785
BRD-K11242872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29183
GSE63048_11_v_6_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00761061
STAC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00490022
K562_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181684
222_AIP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.513983
LE-94-HL75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227271
BRD-K85055578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66935
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.601483
BRD-K62007935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18234
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.560939
BRD-K33005275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03276
GSE48812_8_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.8086
BRD-K86545229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16387
CRCGN009_HEPG2_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.55268
SNU1544	DepMap CRISPR Gene Dependency	1.0	2.51644
EF-22-PB37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.377881
Replication fork protection complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.893
BD-33-HT38_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.560491
GSE206729_5_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Extravillous cytotrophoblast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.243
TRMT44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15391
BRD-K65265098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44916
GSE167956_1_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.3839
CEACAM18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00575079
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.952
A549_SRT2104_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175673
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PFSK1	DepMap CRISPR Gene Dependency	1.0	2.05626
BRD-K17367110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88459
SOWAHD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0236
AC-97-KP88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.689558
GSE158834_2_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K79065821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06654
CRCGN012_HEPG2_24H:G03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2836
CRCGN015_HEPG2_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.48864
GSE258991_5_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
S0-EE-Y4UM_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.14834
LE-80-QM43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.290834
MBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47216
BRD-K49419779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17988
CC-46-CE74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225978
BRD-K82432417	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.18693
LF-94-HB11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.328532
CRCGN015_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.64205
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.87869
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.72441
PD-05-HV36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.76672
FANCM-MHF complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN015_HEPG2_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0487
Muscle Degeneration	DisGeNET Gene-Disease Associations	1.0	null
DC-49-EJ23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224783
DC-93-NP78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.33727
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TKFC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00887352
WDR59	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09164
DC-84-GJ21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.924622
CRCGN015_MCF10A_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3611
GSE171292_5_v_2_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.15645
FE-10-KQ78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.18055
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6087
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.64155
DA-81-VY50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.26914
9473_U2AF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.710044
BRD-K23361743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23986
BRD-K74892102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05055
GSTA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13747
GSE201042_6_v_10_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Uterus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.57762
DPYSL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00502555
TOP2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00355867
BRD-K22485581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15373
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.5109
KCNH5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00443544
MAVER1	DepMap CRISPR Gene Dependency	1.0	2.6552
KCNC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00722589
BA-28-XM73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.460258
4955_MED4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.552898
MCF7_SRT2104_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.011132
BRD-K11705648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00871
BRD-K07624584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65916
GSE193258,GSE193259_5_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.4999
RRP36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04327
COMA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.362
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K14732815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21236
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.35214
CRCGN015_MCF10A_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.17705
RGPD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60996
TDG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00689613
CC-55-CD84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317051
MYC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00452348
BRD-K65969715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09085
BRD-K18197334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.92456
CRCGN012_HEPG2_24H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11145
BCL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15893
POU5F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38754
BRD-K04731905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07552
Endonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.779
GSE242083,GSE242098_2_v_0_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TTC642	DepMap CRISPR Gene Dependency	1.0	2.53821
PMC7782530-42003_2020_1528_MOESM4_ESM.xlsx-Cohort_807b_for_AR_analysis-PR807a_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN013_HEPG2_24H:B07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.99123
CB-16-SY72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.75272
496100640_PCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.973
BRD-K05940224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85909
CC-91-RO81_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202835
DNAJA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1059
9534_UBL5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.526821
UD-07-US73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.00817
MCF7_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169923
GSE137325_2_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EC-82-LV30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.29687
SPIB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00931698
BRD-K95854766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28261
Ovarian carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358999
BRD-K52838863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28572
AC-55-GO91_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.305477
BRD-K13113551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39147
BRD-K71138333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46183
GSE149264,GSE149267_9_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216043_11_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.06004
GSE48812_3_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04185
ARHGAP18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.005086
JD-01-RA07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.377847
PMC10769395-media-3.xlsx-S3B_Activated_EF_TF_genes-Ebegboni_et_al_Supplemental_Table_S5B_Transcription_factor_genes_-_Decreased_expression_following_depletion_of_EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K12705251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11568
BRD-K56341841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0526
BRD-K93998074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3321
MB-15-ZF03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.60859
AE-73-KX58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.304491
EC-96-OH91_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.296636
FB-91-BU05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.386133
JHUEM7	DepMap CRISPR Gene Dependency	1.0	2.79159
LD-39-FL02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219766
CCDC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02898
PMC10679653-mmc2.xlsx-ISL1_KO_Markers_L-Unnamed_0_ISL1	Rummagene Transcription Factor Associations 2026	1.0	null
4153_INTS8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.516663
BRD-K47087435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14148
BRD-K42126874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.49818
BRD-K44626845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58061
Nuclear MIS12/MIND complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.164
ES5	DepMap CRISPR Gene Dependency	1.0	3.06945
SIGLEC15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00809494
BRD-K42605555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25885
AA-58-FJ71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.393447
Spindle microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.148
7411_ROMO1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.677877
CRCGN012_HEPG2_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0527
PMC12354803-42003_2025_8643_MOESM2_ESM.xlsx-2w_TP63_positive-Gene_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K13888422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.76953
GSE144838_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:L09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12579
AC-17-PI61_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.287134
BRD-K24396618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00736
HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
CARD6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0067108
HIVEP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00476362
BRD-K16044155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78465
GSE190186,GSE190188_8_v_5_apoe_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.73488
CRCGN017_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5749
GSE149139_1_v_0_carm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.22
CRCGN016_MCF10A.TP53.M_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9437
BRD-K89277562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25425
PB-05-XP37_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272322
MED10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1463
9435_TUT1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.615536
MYF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0497
10400_ZNF497_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.42362
Transverse filament	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.596
GSE218356_1_v_0_cited1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DD-96-DE39_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299481
AA-45-BL29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234935
A549_Celecoxib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138657
MCF7_Iniparib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193221
GSE169356_0_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CB-24-AT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.848445
BAG3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00376413
JF-96-HH81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.566381
BRD-K66253165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68501
CRCGN010_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.33653
CRCGN015_HEPG2_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.59566
CTV1DM	DepMap CRISPR Gene Dependency	1.0	2.98663
OUMS23	DepMap CRISPR Gene Dependency	1.0	2.70174
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.03579
CRCGN010_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06881
BRD-K08899466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35955
FE-49-VJ28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.394921
AC-30-XU83_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.455946
CRCGN013_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.02295
GSE114690_2_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6436215-13073_2019_626_MOESM2_ESM.xlsx-PCM-IRF2_IRF2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K14211116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.31318
PGR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00530823
GSE150072,GSE169209_6_v_11_qser1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Chromosome passenger complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.17
DAAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21343
FDCSP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00582919
GSE113005_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VF-06-RV33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.44034
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HIPK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00482658
JE-22-JR20_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.04743
GSE165548_2_v_1_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Acute myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.127
GABRR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00502563
BRD-K75243062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05415
DCTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56307
CTSC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00575613
GSE137702_2_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K30799912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87031
CD-20-MH57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20746
CRCGN013_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.43745
CEP89	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0066616
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.368
BRD-K34009761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2905
GSE111247_2_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JB-14-ZM03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.408694
ID-00-IC14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.980813
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22017
Vagina	GTEx Tissue Gene Expression Profiles 2023	1.0	2.24674
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TIMD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532873
SBNO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00572381
GSE128076_1_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZD-78-BS65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284576
BRD-K66735533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5645
13_AARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.91439
BRD-K34343777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40873
GSE223008_9_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.82123
DCAF13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00605893
BRD-K13849122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72162
Protonema	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.322
CRCGN008_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5971
AD-34-TG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.462705
FTSJ3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00617219
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243965
BRD-K24838542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11078
106_ACTL6A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.517151
CRCGN015_MCF10A_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.48205
GSE62843,GSE64371_4_v_0_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54565
GSE184884_2_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12130184-12276_2025_1441_MOESM5_ESM.pdf-3-THAP12_THAP12	Rummagene Transcription Factor Associations 2026	1.0	null
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DE-48-HZ49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.43555
BRCA1-A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.702
JA-02-IU07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207049
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ADM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00553373
SCRT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4847
BRD-K10130686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24295
SNAI2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.983
GSE111247_0_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A81260764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32124
BE-71-AV63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.591325
D458	DepMap CRISPR Gene Dependency	1.0	2.57765
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6335
GSE148200_3_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0351
HPN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00628937
GSE146982_7_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	204.235
GSE117730,GSE117732_0_v_2_apobec2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K00401259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14142
RZZ complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.523
GSE244072_10_v_3_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HC-74-HM63_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.279297
CRCGN015_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.20335
MAK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00496341
PB-09-OE00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.3098
AA-56-JY17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.400586
B-lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.964
OA-54-FL10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.97742
AB-25-XU75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261218
TICAM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00851269
GA-16-IU17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206515
GSE221356_1_v_0_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ri1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.579
Kidney - Medulla	GTEx Tissue Gene Expression Profiles 2023	1.0	3.49584
CRCGN015_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.41911
8921_TIMM23B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.521065
5810_NRDE2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.678456
THEMIS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00747888
HAUS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.077
PMC11511861-41420_2024_2216_MOESM2_ESM.xlsx-GSEA_siYAPsiTAZ-SITAZ_UP__MYC_EZH2_H3K27M3BOUND_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K58242935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56562
replication fork processing	GO Biological Process Annotations 2025	1.0	null
5430_NAA38_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.611369
AE-52-NW93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200938
MCF7_Prednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168902
CE-77-JB44_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257189
CRCGN013_HEPG2_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28412
BRD-K84178323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67058
CD37	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00565502
GSE244072_10_v_9_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K78828094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71828
CRCGN013_HEPG2_24H:L21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29654
BRD-K49307935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35428
BRD-K62256869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2216
GSE115395_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K42150052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2248
SA-32-CC58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.408794
DF-40-CD57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217756
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.3
RA-42-CM42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.09281
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.37886
EC-67-PV87_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.57005
CRCGN016_MCF10A.WT.HP_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.09358
ED-27-OE11_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233823
BRD-K44458042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.16756
GSE207282_1_v_0_polydatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
6549_POLR2H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.512498
BD-33-HT38_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2788
GSE171724_4_v_6_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JA-85-SW39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224511
OC-15-PM40_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227686
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.00739
DASH complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.302
CRCGN015_MCF10A.WT.HP_24H:I14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02698
GSE158834_7_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NC-01-ET52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231499
CD59	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00408088
OB-17-DQ74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.87479
GSE153354_0_v_1_tcf19_human	RummaGEO Gene Perturbation Signatures	1.0	null
7751_SEC61A1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.607146
CRCGN011_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18945
BRD-K31250130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97607
CRCGN015_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.78649
IC-18-TY61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.869425
IB-33-TE51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275495
GSE140092_0_v_1_socs3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.62428
2543_EIF2S3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.734066
BRD-K36135420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10036
CRCGN010_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20351
GSE252864_0_v_3_smad4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K69184209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10964
ZD-85-ND87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.08256
DNA Repair	Reactome Pathways 2024	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.21695
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of protein ubiquitination	GO Biological Process Annotations 2025	1.0	null
CRCGN015_MCF10A.TP53.M_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.36445
ZNF816	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	75.6866
CRCGN015_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.29656
GSE135514_2_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CBX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00453529
F2R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49829
BRD-K03812127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64238
BRD-K81574470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29773
CAMP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00537434
MCF7_Pelitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111982
4061_IGBP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.515373
EPB41L4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09461
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SC-02-RZ08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202918
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.319
BRD-K94516254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92216
CB-12-HC20_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.309505
GSE201668_0_v_1_ncor2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SMYD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00375978
BRD-K54107674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20701
BB-09-GD09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.33647
6793_PRPF31_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.805641
TCF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8711
BRD-K53499221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.34628
GSE146982_3_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GCIY	DepMap CRISPR Gene Dependency	1.0	2.5404
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.824149
gamma-tubulin large complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.6
CRCGN017_MCF10A.WT.HP_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.20515
COX7A2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84749
PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_in_HEK_XBP1s_ATF6-Unnamed_1_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE124410_6_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DE-58-OW37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.348499
GA-47-MH68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.963367
1583_CHMP3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.630327
DA-66-OE69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225587
BRD-K57262525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37747
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.80267
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-9.38244
GSE112860_9_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K54141134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22639
ERF::NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.665
BA-59-EN38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.21337
ED-71-GA72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225881
MDA-MB-436 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.548
BRD-K52383401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23464
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.00915
WNK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00542772
PMC11214527-mmc5.xlsx-TP53-gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
SC-17-WW78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245657
Diabetes Mellitus	DisGeNET Gene-Disease Associations	1.0	null
BRD-K11781871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43135
GSE206516,GSE206518_3_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
4149_INTS4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.732119
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.58215
BRD-K59975583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27475
BRD-K31801624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02162
PMC10824666-43018_2023_699_MOESM2_ESM.xls-Suppl_Table_S4-AM-1882_AUC_vs_Gene_Expression_PRISM_Breast_and_Ovarian_Cancer_Cell_lines_n_58_1_PRDM6	Rummagene Transcription Factor Associations 2026	1.0	null
5494_NCBP2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.514499
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.4662
BRD-K85901675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33133
MCM10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00818892
BE-04-AN21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.05873
PRKAR1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00394132
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.662977
ZNF549	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.4908
BRD-K68041793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92264
HA-22-CY42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.16759
BC-75-FA82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.514205
CE-18-ZM38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.911937
8228_SNRPD1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.704163
RAB41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32188
PC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24395
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.06778
BRD-K11013450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67657
PA-25-OV46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220294
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-55-XA97_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.50444
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
AD-59-IN33_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258573
CA-90-RU33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.40312
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.18384
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:E15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.11834
DD-55-SD64_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226494
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TF-29-QU48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.5247
BRD-K57464717	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39975
CRCGN016_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.89201
Telangiectasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
9380_TTC1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.521826
BRD-K23670243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41495
JR	DepMap CRISPR Gene Dependency	1.0	2.7284
DA-07-LL18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.35712
BRD-K47254434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20083
3436_RACK1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.02966
Spindle midzone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.79
GA-94-MC54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.29088
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K46805838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47196
AB-09-NX37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213721
CB-13-ZM26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232178
CRCGN016_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.89432
CLEC4M	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00701331
GSE249404_0_v_1_oxytocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K50474387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54964
BRD-K61316494	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30435
CNTFR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00865637
BRD-K05060234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10753
AA-86-YV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.45832
BRD-K13044705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73172
496100625_FWM_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.34258
CRCGN008_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3438
GSE147943_0_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SIX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16171
GSE180200,GSE180201_15_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K53224741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2363
CRCGN017_MCF10A.WT.HP_24H:E14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.53815
BRD-K07437885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03729
TFAP4::ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.7404
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
BRD-A64374397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15847
PB-18-HD85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206484
AD-54-FG24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303649
CMG complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.674
1197_CARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.865267
2376_DROSHA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.627134
Congenital hypoplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.758
AC-49-NG46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.435184
4951_MED28_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.11527
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.4856
CHGA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8293
GSE146982_7_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE70499_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kinetochore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.647
FB-39-CW59_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.424199
OE-03-IU44_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.334532
BRD-K89328601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19909
CRCGN013_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06067
BRD-K45092891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11486
BRD-K93283197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07514
Microcephalic osteodysplastic primordial dwarfism type II	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
FPGS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95611
GSE169356_2_v_5_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-60-DR81_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215301
CRCGN017_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.18235
BRD-A23193246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4831
TCF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4462
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.92472
GSE202434,GSE202438_8_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FANCM-MHF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.379
Mixed Cryoglobulinemia	DisGeNET Gene-Disease Associations	1.0	null
Splenic Marginal Zone B-Cell Lymphoma	DisGeNET Gene-Disease Associations	1.0	null
Ovary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.784093
CRCGN017_MCF10A.TP53.M_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.38565
JE-72-KV75_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246842
CRCGN016_MCF10A.WT.HP_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.20508
GSE146612_2_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
S462	DepMap CRISPR Gene Dependency	1.0	2.49518
BRD-K89660028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13121
DF-75-OU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.54834
BRD-K47572485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52627
CRCGN011_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.17625
TIRAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00551737
2203_DHX15_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.679829
CRCGN012_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.27404
GSE149621_0_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.23871
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6022
GSE213632_3_v_5_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.193
DD-47-GB64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230118
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.755
Myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.073
Mre11 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.548
PDGFRL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00580787
BRD-K89992188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3631
FA-88-II68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.30781
CACNA1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00579667
decreased locomotor activity	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-K50157358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.89804
NBPF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02365
BF-18-MJ41_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211308
BRD-K15876355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3676
CRCGN013_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.43183
JD-81-YX02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289355
BRD-K42862653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23184
CRCGN011_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1726
RA-42-CM42_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.720564
BRD-K35193502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35225
Osteogenesis imperfecta type 12	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.878
GSE137144_3_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A81407814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00127
CRCGN016_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3598
GSE125157_1_v_0_piceatannol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CCL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00526659
KC-10-GC29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.356035
BRD-K05704547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99824
6797_PRPF3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.65889
CRCGN015_HEPG2_48H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.00592
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.95569
VGF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00406286
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.586793
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.06137
GSE186647,GSE217288_11_v_7_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SPC25	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00810471
RH4	DepMap CRISPR Gene Dependency	1.0	2.62962
PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_in_HEK_XBP1s_ATF6-S7_Data_List_of_all_genes_that_were_upregulated_in_HEK293DAX_cells_for_XBP1s_ATF6_vs_Basal_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
XPO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00791987
GSE148252_1_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.61336
BRD-K70343553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00415
BRD-K61943321	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58598
BE-25-UR78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209235
ILDR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00493893
YF-64-PQ11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.401511
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:J21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7476
CRCGN011_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.33295
BRD-K98169006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71408
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.427256
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.321
BRD-K80766355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17873
RD-57-WQ44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227572
BRD-K77203880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33426
GA-16-IU17_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.337414
CRCGN014_HEPG2_24H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.547
BRD-K53127431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22233
LCP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00515489
MCF7_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158518
ETV2::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9113
VD-76-SO91_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.487207
FD-88-CF51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.514343
TM31	DepMap CRISPR Gene Dependency	1.0	2.08524
ZBTB32	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00495016
BRD-K45056520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52852
BRD-K47498351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46115
SLC12A9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00640313
CRCGN017_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.88185
GSE157036,GSE166411_3_v_1_halofuginone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPL23A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00997032
PMC8410861-41467_2021_25544_MOESM32_ESM.xlsx-MCR-MCR_cells_-_DGE_iGCA_testis_vs_adult_testis_from_GSE112013_and_GSE124263_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
JA-23-QE71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.509193
DE-85-FR73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.334646
GSE171837_0_v_3_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AA-12-VW53_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.374555
SAOS2	DepMap CRISPR Gene Dependency	1.0	3.12667
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.40533
7607_RUVBL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.506443
BA-69-DU95_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.32848
BRD-K43611837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21179
DA-86-GO43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.28112
S0-EE-XYMJ_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.65095
FRAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01223
JAM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0056994
BE-81-QL64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.355392
BRD-K76976010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06585
BRD-A66566298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25422
GSE149769_1_v_0_nlrp12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.49425
AA-46-GL76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.321972
CRCGN016_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.83653
GSE214823,GSE214824_3_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EE-01-DO31_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229898
EA-22-SB72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.868426
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.630833
TNK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00531942
GSE161170,GSE161268_1_v_3_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.79209
QB-42-MC63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.743114
A549_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134486
BRD-K57734337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10303
GSE232624_4_v_5_ethanol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.7841
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.32998
CRCGN017_MCF10A.TP53.M_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22956
HC-26-PX74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.395624
BRD-K11474067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19657
BF-26-MB27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.477372
GSE240386,GSE242143_1_v_4_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CC-91-RO81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.395285
EA-02-ZO63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.625197
GD-39-YG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.359254
AD-89-ID99_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249764
8184_SMN2_ENST00000380743.4	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.714835
MutLbeta complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.697
CRCGN016_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.12951
BRD-K86848211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61278
YY1-26981420-C2C12-MOUSE-MUSCLE	ChEA Transcription Factor Targets 2022	1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CENPX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56693
GSE215351,GSE215794_4_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K08259535	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25045
BA-15-LA22_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.798842
CRCGN008_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.5168
ZNF610	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.5847
GSE239844_6_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RBL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25144
CB-42-EI79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202669
HF-36-FK93_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.314044
LC-96-WR85_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.521712
GNAT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00517717
Elg1 RFC-like complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.522
1268_CCDC174_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.607338
MA-31-VM30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2914
YF-00-IN39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.714068
BRD-K00209945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74026