association	dataset	threshold value	standardized value
superficial stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.69131
GTEX-U8XE-1526-SM-4E3HT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81336
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_Ofloxacin_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160998
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
non-hodgkin lymphoma	GWASdb SNP-Disease Associations	1.0	0.375034
Interphase microtubule organizing center	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.935
A549_Epothilone A_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01316
HUH6_LIVER	CCLE Cell Line Proteomics	1.0	2.81044
Visceral heterotaxy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.096
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
skbr3	HPA Cell Line Gene Expression Profiles	-1.0	-0.829315
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.46304
A549_Zileuton_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0398002
Lung adenocarcinoma_LUAD_TCGA-44-6778-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ChIP_NANOG_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Situs inversus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
astrocytoma	GWASdb SNP-Disease Associations	1.0	0.442605
MCF7_Dacinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00717518
HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5774
A549_Mocetinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162102
A549_Tanespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197896
abnormality of the glial cells	GWASdb SNP-Phenotype Associations	1.0	0.333763
hsa-miR-1269b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
arthritis	GWASdb SNP-Phenotype Associations	1.0	0.267658
Idarubicin (hydrochloride)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0148341
GSE217776,GSE217829_4_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PHOX2B-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE120370_0_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
nicotine_myzus persicae_gpl9470_gse18658	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PAX3	ChEA Transcription Factor Targets	1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209699
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163441
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.896879
tonsil_8b1	HPA Tissue Sample Gene Expression Profiles	1.0	1.58539
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.20611
Autoimmune disease of endocrine system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
CD56+_NKCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.16617
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BD-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
u26684	HPA Cell Line Gene Expression Profiles	-1.0	-0.839556
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.866209
lymphnode_4a	HPA Tissue Sample Gene Expression Profiles	1.0	0.959722
GSE139911_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174834
CDC37L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68259
GSE161800_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.230326
A549_AG-490_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.024217
ZNF184	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.8082
STAT4-19710469-TH1 cell mouse-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
connective tissue disease	GWASdb SNP-Disease Associations	1.0	0.14107
BL977 (PLK1)	NURSA Protein Complexes	1.0	null
A549_Selisistat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157364
A549_JNJ-7706621_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0258841
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39233
A549_Entinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197182
congenital hemolytic anemia	GWASdb SNP-Disease Associations	1.0	0.875106
raphe magnus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30413
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-QEG4-0126-SM-48TZE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84336
H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Ovary	GTEx Tissue Gene Expression Profiles 2023	1.0	1.37171
rostral division of OFCi (area 11)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18324
MCF7_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171843
Nasopharyngeal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.189
A549_Meprednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143912
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09099
GTEX-NL4W-0008-SM-4E3I2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852101
HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2194
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QI-01A-11R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72221
Rarb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	60.1328
GSE251992_1_v_0_saracatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Mesna_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131382
CEBPB-23403033-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
496100607_TCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.31725
A549_Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160154
MCF7_Tozasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178056
pou5f1_20526341_human_embryonic_stem_cells_hesc_lof_human_gpl6947_gse21135	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.071401
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.65906
intermediate stratum of m2ADL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61388
glucose metabolism disease	GWASdb SNP-Disease Associations	1.0	0.25668
MCF7_AR-42_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141007
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29D-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52176
SR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.904383
HGC-27 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.971
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
LS-180	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE205316,GSE205317_2_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Alisertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212979
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17816
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
GSE214212_2_v_1_chd6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EWSR1-FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	245.476
GSE186483_2_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormality of the astrocytes	GWASdb SNP-Phenotype Associations	1.0	0.599613
GSE124014_0_v_1_nnmt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Primary spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.986
K562_FLLL32_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207388
posteromedial visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18961
superficial stratum of r11Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22656
A549_PCI-34051_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125828
A549_Azacitidine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145525
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-O5YV-0326-SM-2I5H2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04451
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05782
GSE160817_5_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_IOX2_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165572
GTEX-S7SF-0226-SM-3K2BI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848619
A549_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210982
GTEX-XV7Q-0326-SM-4BRVM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958606
Carcinoma Of Bladder	DisGeNET Gene-Disease Associations	1.0	null
centrosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
MCF7_PD98059_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130429
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.23419
PCM6	CCLE Cell Line Gene Expression Profiles	1.0	1.50439
K562_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170572
thyroid	GTEx Tissue Gene Expression Profiles	1.0	1.24062
MM.1S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.61955
abnormality of coagulation	GWASdb SNP-Phenotype Associations	1.0	0.231356
Psoriasis 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.546
DT-061_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.029663
Rectum adenocarcinoma_READ_TCGA-DC-6160-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-O2-A52S-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Disulfiram_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0273135
ALDH5A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01508
Octamer	MotifMap Predicted Transcription Factor Targets	1.0	null
CA SKI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.852886
Thyroid gland disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.85
SNU-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE245134_2_v_3_atg5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5877-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Motesanib Diphosphate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173622
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MOLP2	CCLE Cell Line Gene Expression Profiles	1.0	2.15718
Sulfisoxazole_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0250654
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3609	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-E2F7_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
Plasma membrane bounded cell projection cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.82
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
MCF7_Entacapone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0220886
Abiraterone1	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.09
K562_PCI-34051_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176415
r11 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.72652
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39759
MCF7_AG-490_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014513
TK-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.915468
Olanzapine_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0219246
A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_1day-MOI-10^4_None_GSE44441	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.90754
hsa-miR-3926	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
normocytic anemia	GWASdb SNP-Disease Associations	1.0	0.875106
JAK2_mutant_40_GSE11003	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.6056
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Perturb_3555_KD_AURKB_SRP230801	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
APTO-253_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0187635
GSE173394_1_v_0_nfatc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0264795
A549_Luminespib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178009
Lung adenocarcinoma_LUAD_TCGA-86-7701-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9817_KD_E2A_SRP103740	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
MCF7_A-366_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127977
PMC3500769-srep00875-s3.xls-CEBP-Time_4_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
Bladder Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
MCF7_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016488
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE158834_10_v_6_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormality of nervous system morphology	GWASdb SNP-Phenotype Associations	1.0	0.116842
Nephroblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.136
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Primary somatosensory area, upper limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58535
Trimetrexate_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0184846
r9 part of the basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01428
GSE146074_10_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_10_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.97589
A549_ITSA-1_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143842
CHP-212	COSMIC Cell Line Gene Mutation Profiles	1.0	null
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.948654
hsa-miR-548c-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
MAGEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20215
tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.83221
GSE202434,GSE202438_3_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K79me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.82711
PSMD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33467
asthenozoospermia	MGI Mouse Phenotype Associations 2023	1.0	null
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08545
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.49487
MOLT4	CCLE Cell Line Gene Expression Profiles	1.0	1.57007
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.98776
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.98029
intermediate stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0154
abnormality of body height	GWASdb SNP-Phenotype Associations	1.0	0.7965
A549_Ofloxacin_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01928
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226249_5_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Crus 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25936
PLB985	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59283
GSE111385_2_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE179974_3_v_5_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10828500-41467_2024_44701_MOESM4_ESM.xlsx-ST12-Unnamed_7_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Pracinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140939
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A7UZ-01A-12R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Triangular nucleus of septum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61388
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25246
hsa-miR-3162-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
Perturb_372_KD_STING1_SRP350677	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE226249_2_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Tuberomammillary nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39927
TRAPPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81285
JUND	ENCODE Transcription Factor Targets	1.0	null
JUN	JASPAR Predicted Transcription Factor Targets	1.0	null
Crus 2, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25524
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7382-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11461876-42003_2024_6975_MOESM5_ESM.xlsx-Supplementary_Data_3-Supplementary_Data_3_Differentially_Expressed_Genes_HSE_THP1_UV_Vs_HSE_THP1_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
superficial stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.312
BRL 54443	DeepCoverMOA Drug Mechanisms of Action	1.0	0.33
K562_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208093
GTEX-UPJH-0526-SM-4IHK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02885
A549_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0270941
MEIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1059
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88961
GSE226249_0_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
preisthmic midbrain tectum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31002
A549_MK-0752_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0286175
SUDHL8	DepMap CRISPR Gene Dependency	1.0	5.36632
nucleus coeruleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07539
A549_2-Methoxyestradiol_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0203669
CA2 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00486
Nimesulide_SW480	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0139348
ARF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69208
GSE205730,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_S-Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194582
OCIMY7	DepMap CRISPR Gene Dependency	1.0	5.44524
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.555
MCF7_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120848
SNU-283	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_744_KD_RASSF2_SRP233387	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
olfactorybulb	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.864546
fetus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE118766_2_v_3_ifng_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S4Z8-0526-SM-4AD4T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2424
Acute Myeloid Leukemia_LAML_TCGA-AB-2959-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.232
Fatty Liver	CTD Gene-Disease Associations	1.0	1.11466
GTEX-U3ZN-0226-SM-3DB8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.01588
Fulvestrant_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0169828
MCC26	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC3500769-srep00875-s3.xls-FOXA1-Time_1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
primary motor cortex (area M1, area 4)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25208
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57736
GTEX-V955-1926-SM-4KL1L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17257
MCF7_MC1568_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01889
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE174498,GSE174500_0_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mitoxantrone (dihydrochloride)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0290596
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Canagliflozin (hemihydrate)_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0207918
CA3 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.69
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00009
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963273
GTEX-UJMC-0326-SM-3GAE2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892627
periaqueductal gray substance, dorsolateral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0744
BFTC-905	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33871
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.900562
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE182680,GSE182683_7_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_BMS-536924_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143117
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_Andarine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192568
Perturb_1362_KD_TRIM28_SRP331117	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
A549_TG101209_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150729
A549_Anacardic Acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202186
PMC11384724-mmc1.pdf-3-BCL11A_BCL11A	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
p1B part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06177
periventricular stratum of VTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63545
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-X5EB-0526-SM-46MVP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20428
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IT-01A-31R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hyperthyroidism	GWASdb SNP-Disease Associations	1.0	0.882166
GSE89018_12_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0226874
GSE119978,GSE180930_2_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A7UA-06A-32R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05534
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08809
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Nearest_Ensembl_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02623
MCF7_Cimetidine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198617
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.885332
K562_Iniparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.020979
K562_JQ1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157544
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6864
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.962306
HL-60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.66008
Crus 1, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01096
coronary artery disease	GAD Gene-Disease Associations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A1A1-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Temsirolimus_SW480	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0226806
Pyridoxine (hydrochloride)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0133401
GTEX-XV7Q-0726-SM-4BRV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936813
GTEX-RUSQ-0826-SM-47JWW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.981702
GSE131649_4_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4739	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
GSE128844_0_v_1_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SE5C-0626-SM-2XCDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08648
oligozoospermia	MGI Mouse Phenotype Associations 2023	1.0	null
Cancer of the testis_Testis_GSE1818	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.4765
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10591
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1992
GSE130217_5_v_2_sesn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.099
Docetaxel_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0148555
Ciliary pocket membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.404
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE94814_2_v_3_reck_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
mantle zone of r11Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23319
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67939
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987567
Dlx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.2821
MCF7_Crizotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179367
PMC7895828-41419_2021_3488_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_3_List_of_deregulated_genes_in_c-MYC_altered_human_HCC_from_TCGA_LIHC_dataset_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U3ZM-1526-SM-3DB9D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896134
MOLP-8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cytosol	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18968
hsa-miR-938	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
MCF7_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126751
alzheimer disease	GWASdb SNP-Phenotype Associations	1.0	0.424654
UBTF	ENCODE Transcription Factor Targets	1.0	null
A549_Glesatinib(MGCD265)_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0217744
Lung squamous cell carcinoma_LUSC_TCGA-66-2793-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SJXC-0326-SM-2XCFI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33513
MCF7_Cediranib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184094
u266	HPA Cell Line Gene Expression Profiles	1.0	2.61494
abnormal sperm flagellum morphology	MGI Mouse Phenotype Associations 2023	1.0	null
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.71688
malignant glioma	GWASdb SNP-Disease Associations	1.0	0.442605
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.963001
Docetaxel_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0216146
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7861-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Intracellular non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.623
22RV1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Graves' disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.006
GSE199255,GSE199356_4_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.833528
GSE210101,GSE210114_8_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Medullary collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.833
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCF7_JQ1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016309
A549_PF-573228_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0220617
periventricular stratum of p1B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01213
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275556
A549_Tazemetostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129559
HS 852.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.840201
A549_CUDC-907_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128937
NCI-H1666	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.76423
GSE134214_0_v_1_ell2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.874571
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
blastocysts	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.23084
Norepinephrine (hydrochloride)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0296533
OCI-AML2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.840317
uterine neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.379543
GTEX-QDVN-0526-SM-48TZ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05187
Perturb_2143_KO_ASCC3_SRP282634	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-NL3H-0011-R3a-SM-2I3GL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922829
MON	DepMap CRISPR Gene Dependency	1.0	2.79304
VI, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.861571
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TIAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16908
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.904651
Lymph_Node-plasma cell	Tabula Sapiens Gene-Cell Associations	1.0	4.32029
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30716
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.2205
A549_Obatoclax Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0262581
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.7364
GSE153836_11_v_2_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8850648-Table11.xlsx-KS-DEGs_Vs_Liu_et_al_2019-Are_listed_the_239_DEGs_in_common_between_the_current_study_and_the_published_RNAseq_data_of_NRF1_overexpression_in_human_cells_Liu_et_al_2019_NRF1	Rummagene Transcription Factor Associations 2026	1.0	null
non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Vitamin K4_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0104507
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04543
renal carcinoma	GWASdb SNP-Disease Associations	1.0	0.698242
GSE224311_3_v_2_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_AICAR_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0338505
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.827463
Vogt-Koyanagi-Harada disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
GTEX-W5X1-0526-SM-3GILH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27378
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
MCF7_A-366_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147023
hsa-miR-4457	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
PMC8948659-ADVS-9-2104491-s013.xlsx-Sheet1-Supplemental_Table_9_related_to_Figure_7_Differential_genes_highly_correlated_with_TP53_deletion_in_H929_cells_by_RNA-seq_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
E2F4_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EMX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.9644
crizotinib_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0200858
HY-50713	DeepCoverMOA Drug Mechanisms of Action	1.0	0.56
graves' disease	GWASdb SNP-Disease Associations	1.0	1.53792
GTEX-REY6-0826-SM-2TF4S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51582
K562_Lapatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201536
JHUEM1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.19461
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCF7_Tranylcypromine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017377
A549_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.03085
DAUDI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.52567
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.5887
GSE234289_4_v_1_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118766_2_v_0_ifng_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cell type cancer	GWASdb SNP-Disease Associations	1.0	0.283804
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7866-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UMUC1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.63929
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230052
A549_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213264
glioma	GWASdb SNP-Phenotype Associations	1.0	0.333763
lung cancer	GWASdb SNP-Disease Associations	1.0	0.50144
K562_WHI-P154_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0267155
Pitavastatin (Calcium)_SW480	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00924917
MCF7_Divalproex Sodium_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181759
MCF7_Sorafenib Tosylate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148696
A549_ENMD-2076 L-Tartaric acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0203582
16207381-Table1Sb	GeneSigDB Published Gene Signatures	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8637-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9821_KD_MYB_SRP103740	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-18.6021
A549_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202515
Septofimbrial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21986
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48426
MCF7_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0234816
GSE135350_3_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
lateral hypothalamic area, tuberal part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.896316
hsa-miR-372	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
GSE223008_5_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Irinotecan_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0202668
non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_1_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
intermediate stratum of PHyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.60321
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36612
GTEX-TML8-0008-SM-4DXUI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01608
GTEX-WYBS-0626-SM-3NMAS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927476
HS 940.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.997046
hsa-miR-520b	TargetScan Predicted Conserved microRNA Targets	1.0	0.336728
female reproductive organ cancer	GWASdb SNP-Disease Associations	1.0	0.324948
Kidney Chromophobe_KICH_TCGA-KL-8342-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Palmatine (chloride)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0224581
A549_Ivosidenib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0355141
primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.39179
internal cortical nucleus of inferior colliculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48763
PMC8872993-41380_2021_1274_MOESM4_ESM.xlsx-Table_S6-Supplementary_Table_S6_Differentially-Expressed_Genes_after_T-3_KD_in_hiPSC-derived_Astrocytes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
mantle cell lymphoma	GWASdb SNP-Disease Associations	1.0	0.698242
coronary artery disease	GWASdb SNP-Disease Associations	1.0	0.904952
Lung squamous cell carcinoma_LUSC_TCGA-63-A5M9-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
adult	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.345928
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06517
GTEX-XPVG-0826-SM-4B654	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839227
urinary tract neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.295523
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.16126
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76866
A549_Ki8751_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016666
K562_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164156
K562_Disulfiram_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163265
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0368
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
MCF7_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124844
PMC10641274-mmc2.xlsx-FOXK1_Insulin-SYMBOL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
HM7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
pancreas	GTEx Tissue Gene Expression Profiles	-1.0	-1.15815
Mitoxantrone (dihydrochloride)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0236946
hematologic cancer	GWASdb SNP-Disease Associations	1.0	0.11773
Lung squamous cell carcinoma_LUSC_TCGA-O2-A52W-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AURA	Kinase Library Serine Threonine Kinome Atlas	1.0	null
FOXA2-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
Leukocyte	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.72294
RKO-E6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
nuclear membrane	GO Cellular Component Annotations 2023	1.0	null
intermediate stratum of m1AL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.01527
hsa-miR-4275	TargetScan Predicted Conserved microRNA Targets	1.0	0.136254
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE179880_10_v_3_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdaloid complex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.73276
SARS-ddORF6_60Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.11847
Perturb_2917_KD_FOXO3_SRP325840	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.9601
MCF7_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169877
FUCA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14728
osteoclasts	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.034
SPI1-22790984-ERYTHROLEUKEMIA-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Dlx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	13.9995
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19027
intermediate stratum of m2Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16379
Doxycycline (monohydrate)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0255706
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01055
abnormality of the endometrium	GWASdb SNP-Phenotype Associations	1.0	0.599613
A549_Tubastatin A HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0346226
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.17466
Irinotecan_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0302022
K562_Carmofur_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193532
VI	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.927033
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02889
HAUS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03764
PMC10803041-elife-86204-supp2.xlsx-snRNA-seq_Snc-KD_in_HT-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13946
Microtubule minus-end	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.804
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A86F-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WHSE-0926-SM-3NMBS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80334
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
POU2F1-35413990-HUMAN-ARPOSCRPROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
A549_Selisistat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158701
molt4	HPA Cell Line Gene Expression Profiles	1.0	1.32763
A549_Nintedanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0252898
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7102-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6941_KO_Rbm20_SRP403612	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
estradiol_mus musculus_gpl4134_gse23072	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_12199_KD_XPC_SRP310546	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Prostate adenocarcinoma_PRAD_TCGA-KK-A59V-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KMS-26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.41468
GTEX-R55E-0726-SM-48FCZ	GTEx Tissue Sample Gene Expression Profiles	1.0	3.41295
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2409
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.077575
CA46	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.876913
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_A-366_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0243188
Cone photoreceptor outer segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.612
MZ7-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Rootlet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.909
GTEX-R55D-1426-SM-48FEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36422
A549_Cerdulatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121113
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
protein localization	GO Biological Process Annotations 2023	1.0	null
EN1	JASPAR Predicted Transcription Factor Targets	1.0	null
cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18271
GTEX-U8XE-0126-SM-4E3I3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17224
K562_Entinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149987
PDE10A_KO_GDS4542_291_mouse_striatum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SLR24	CCLE Cell Line Gene Expression Profiles	-1.0	-1.49157
dorsal entopeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37339
FADU	CCLE Cell Line Gene CNV Profiles	1.0	2.2542
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.863214
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.956254
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE186440,GSE186443_3_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Sarcoma_SARC_TCGA-DX-A6YT-01A-21R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Neoplasms	CTD Gene-Disease Associations	1.0	1.01852
GSE168807_0_v_8_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-106a	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
Ciliary transition zone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.152
molecular layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1814
A549_WP1066_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016636
nucleus sagulum, deep part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61227
GSE94768_5_v_4_pofut1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152055_0_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_XAV-939_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200426
Msx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.5106
III, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.938132
outer SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.77943
A549_Carmofur_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0211475
GSE180200,GSE180201_5_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Capivasertib_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00952992
Body Height	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876499
A549_Selisistat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0311569
F5	DepMap CRISPR Gene Dependency	1.0	2.04733
SRC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11641
A549_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161867
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09099
MCF7_BMS-536924_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148699
Alx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.3493
Ciliopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.852
JcPV part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.77806
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.50655
Dorsomedial nucleus of the hypothalamus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4754
GSE210101,GSE210114_5_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of TSPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3364
SET2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-300	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
CTCF	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-573	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
CBC361 (MALT1)	NURSA Protein Complexes	1.0	null
GSE193334_1_v_0_six1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Teratocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.962
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2239
A549_BMS-536924_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173414
COLO-783	COSMIC Cell Line Gene Mutation Profiles	1.0	null
arthritis	GWASdb SNP-Disease Associations	1.0	0.352461
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WH7G-1926-SM-4LVMM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49662
Lung adenocarcinoma_LUAD_TCGA-64-5774-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_GSK1070916_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0111157
tobacco use disorder	GAD Gene-Disease Associations	1.0	null
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880069
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36333
USP2_KO_GDS5079_25_mouse_kidney	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
A549_TMP195_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0344831
PMC10510228-13287_2023_3481_MOESM7_ESM.xlsx-DEGs-Differentially_expressed_genes_DEGs_in_bone_marrow-derived_MSCs_from_six_human_donors_cultured_at_high_confluency_MSC-HC_versus_low_confluency_MSC-LC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE218060_7_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Unnamed_1_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
astrocytoma	GWASdb SNP-Phenotype Associations	1.0	0.599613
GTEX-T2IS-3126-SM-32QPK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931932
GTEX-T6MO-1626-SM-32QOM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904257
alar part of terminal hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12488
GSE151119_2_v_0_hsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NL3H-0008-SM-4E3HU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884027
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.904584
DU 145	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33871
GSE213588_8_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Tucidinostat_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0111008
TET1	ChEA Transcription Factor Targets	1.0	null
Bone_Marrow-plasma cell	Tabula Sapiens Gene-Cell Associations	1.0	0.983849
GSE223008_5_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Bisindolylmaleimide IX_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139353
PHOX2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.943
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051184
GSE237040_6_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Peretinoin_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0256933
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10391
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.8903
GTEX-XQ3S-2726-SM-4BOP2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.98971
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.63572
KMS26	CCLE Cell Line Gene Expression Profiles	1.0	2.3768
macromolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08984
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.59553
abnormality of the skeletal system	GWASdb SNP-Phenotype Associations	1.0	0.070172
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81A-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NPHP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.067
OTS514_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0275961
HOXD13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46479
GSE126127_2_v_3_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.491704
PXR (PXR:RXR)	MotifMap Predicted Transcription Factor Targets	1.0	null
A549_BMS-911543_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216216
GSE145915_0_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Microtubule cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
HS 695T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.46028
OAW42	DepMap CRISPR Gene Dependency	1.0	9.98595
PSAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70945
GSE58724_1_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
G122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.847258
GSE136869_1_v_0_lpar2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.95805
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.143
K562_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0211897
Lung squamous cell carcinoma_LUSC_TCGA-43-6143-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-W5WG-1326-SM-4LMI9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845372
GTEX-O5YU-0008-SM-4E3I7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39879
Prostate adenocarcinoma_PRAD_TCGA-EJ-7789-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9534852-41598_2022_20572_MOESM4_ESM.xlsx-Sheet1-Supplementary_Table_S4_Transcriptomic_data_related_to_AHR_function_considered_for_metabolic_reconstruction_model_generation_AHR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890365
GSE142684_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_16573_KO_Grn_SRP070944	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.61332
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.99178
POLR2A_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2218_BREAST	CCLE Cell Line Proteomics	1.0	2.96977
Paramedian lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.28865
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28378
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.13261
abnormality of the respiratory system	GWASdb SNP-Phenotype Associations	1.0	0.189627
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A265-06A-21R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PAX3-FKHR-20663909-RHABDOMYOSARCOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE94849_1_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
KMM1	CCLE Cell Line Gene Expression Profiles	1.0	2.04246
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
layer VI of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.900466
GTEX-R55F-0011-R6A-SM-2TF4L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926655
A549_GSK-LSD1 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150458
septohypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17391
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.05334
Dantrolene	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.63
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8C_Het1A-HNF4A_2d_5x_closed-Gene_Name_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Outer dynein arm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.815
A549_SRT1720 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0362159
Weight Loss	CTD Gene-Disease Associations	1.0	1.28858
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.5618
A549_Triamcinolone Acetonide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173307
liminal reticular formation of m2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51749
Cochlear nucleus, subpedunclular granular region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15601
GSE161184_0_v_1_tlr7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
atherosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.686325
NCI-H2135	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_Busulfan_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166046
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.18447
A549_Tubastatin A HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016039
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-06A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JHH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.988296
ZNF446	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25108
EZH2	ENCODE Transcription Factor Targets	1.0	null
ZNF558	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	98.5618
A549_Aurora A Inhibitor I_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184787
UterusCorpus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.879025
GTEX-O5YT-0008-SM-4E3IQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58915
GSE135350_2_v_7_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BCP1	CCLE Cell Line Gene Expression Profiles	1.0	2.09704
PMC5795782-supp_gad.302646.117_Supplemental_Table_S1.xlsx-Table_S1_1-Supplemental_Table_S1_1_Genes_significantly_downregulated_by_ARID5B_knockdown_ARID5B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_2-Methoxyestradiol_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0115778
Cerebral peduncle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.642
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.50279
A549_Streptozotocin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0291
GTEX-QEG5-0426-SM-2I5GJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33101
GSE140576_0_v_2_plag1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_PHA-680632_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014473
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
18794137-SuppTable1b	GeneSigDB Published Gene Signatures	1.0	null
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_EVT-Gene_Symbol_GCM1	Rummagene Transcription Factor Associations 2026	1.0	null
GR	MotifMap Predicted Transcription Factor Targets	1.0	null
K562_Lapatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153151
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
agranular insular cortex (area Iag)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00027
GTEX-PLZ4-1226-SM-2I5FE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876296
posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.46777
GSE163297_0_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PA-TU-8902	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14162
GSE126463_1_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WYJK-1726-SM-3NM9U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09024
REST_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
external granular (germinal) layer of lower rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26739
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.24259
GTEX-WRHU-0926-SM-4E3IG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12432
GSE164757,GSE164759_4_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Pparg::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.1703
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02683
thyrotoxicosis with diffuse goiter	GWASdb SNP-Phenotype Associations	1.0	1.38972
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.416
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11718
GSE127261_1_v_2_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
nih 3T3	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46784
SPI1-22096565-GC-B-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
HOXA11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3647
GTEX-Q2AH-0926-SM-48TZK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00614
GSE223008_4_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-192-5p	MiRTarBase microRNA Targets	1.0	null
bone disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.256228
hepg2	HPA Cell Line Gene Expression Profiles	-1.0	-1.81699
GSE147210_3_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JB-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Congenital nongoitrous hypothyroidism 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.444
AN3-CA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.107619
GTEX-X5EB-2026-SM-4E3KA	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04282
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC6941881-mmc4.xlsx-IR_only_down_DEGs-List_of_DEGs_that_are_downregulated_upon_PRMT5_KD_only_in_IR_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_CUDC-101_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0088274
A549_Resveratrol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0284941
A549_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212951
TMEM88B_KD_GPL10558_471_human_cardiovascular progenitors cells differentiated from hES cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
A549_JNJ-7706621_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150383
Nrf2_deficiency_GDS3406_156_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
r7 part of parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.27482
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44Q-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Doxorubicin (hydrochloride)_SW480	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0200859
SNU626	CCLE Cell Line Gene Expression Profiles	-1.0	-1.71307
GSE101239_4_v_1_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_TGX-221_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0358955
A549_CUDC-907_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135723
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
K562_PJ34_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0203196
VZ in subgenual cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.834903
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17904
GSE244233_1_v_0_quercetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Down_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC2694838-1471-2164-10-241-S2.xls-Sheet1-Regulated_genes_by_ZNF191_knockdown_ZNF24	Rummagene Transcription Factor Associations 2026	1.0	null
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
LU-134-A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC6405523__F4	PFOCR Pathway Figure Associations 2024	1.0	null
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
COLO775	CCLE Cell Line Gene Expression Profiles	1.0	1.46272
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4698-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7565
PHOX2B-30127528-KELLY-HUMAN-BRAINNEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE178292_0_v_3_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
magnocellular diagonal band nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06469
Irinotecan_NCI-H23	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0269977
LOU-NH91	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.86441
GSE148066,GSE157787_8_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1793	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.66666
K562_Daphnetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144919
intermediate stratum of m2AL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15345
A549_Thiotepa_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0291013
Lung adenocarcinoma_LUAD_TCGA-55-6969-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Finasteride_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.020456
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A3M9-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TENT4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43813
Brain Lower Grade Glioma_LGG_TCGA-DU-7013-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204407
primary auditory cortex (core)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.31236
SNU668	DepMap CRISPR Gene Dependency	1.0	2.65322
9+2 motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.619
KP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0797
GTEX-T5JC-1526-SM-4DM68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942669
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7651-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07356
liver	HPA Tissue Gene Expression Profiles	-1.0	-1.28242
Perturb_9730_KD_SRP55_SRP106195	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	18.4815
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.586
reproductive organ cancer	GWASdb SNP-Disease Associations	1.0	0.221482
Brain Lower Grade Glioma_LGG_TCGA-KT-A7W1-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Quercetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167193
Inner dynein arm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.628
GSE114013,GSE114014_0_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100352_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.29864
GTEX-RN64-1226-SM-2TC6E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891057
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_ALL-SYMBOL_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
magnocellular (medial) subparafascicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63602
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.956254
GSE242647_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157509
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE179974_3_v_4_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.46595
GSE70935_2_v_4_cyfip1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203362_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ciliary pocket	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.05
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A913-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-1321	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
cone-rod dystrophy 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
Perturb_2747_KD_MYC_SRP358852	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE212312_1_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07009
Fingolimod (hydrochloride)_LS 180	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0122416
DMS79	CCLE Cell Line Gene CNV Profiles	1.0	1.62801
GTEX-PX3G-0126-SM-2I3EN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824656
K562_EED226_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0260515
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.920667
cancer	GWASdb SNP-Disease Associations	1.0	0.172564
AMIGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66923
hsa-miR-4766-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
K562_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186437
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-A4BC-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.61955
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193258,GSE193259_9_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ISX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1156
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	3.26513
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
A549_PCI-34051_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192202
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A42E-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_AG-14361_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153316
GTEX-T6MN-0626-SM-32PM9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20031
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_JQ1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187435
GTEX-VJYA-0826-SM-4KL1M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11565
GTEX-Q2AH-0326-SM-48U1K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857904
K562_Alendronate sodium trihydrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0285552
GSE121198,GSE129782_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE161846,GSE161849_4_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4416
Perturb_7260_KD_EP300_SRP193326	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
CHD2	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-588	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24856
Lung adenocarcinoma_LUAD_TCGA-78-7155-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FIPI HCl	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.39
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2955-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
KLF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62201
ZNF257	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.1051
anterior amygdaloid area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.8915
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.19698
CL14	CCLE Cell Line Gene Expression Profiles	-1.0	-1.89168
TrigeminalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.830577
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Roscovitine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0358137
CCK-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER	ChEA Transcription Factor Targets 2022	1.0	null
zona incerta, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05143
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
GK01981	DeepCoverMOA Drug Mechanisms of Action	1.0	0.29
internal granular layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44347
GSE226316_0_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12917211-Table1.xlsx-Table_S13-Table_S13_Gene-level_perturbation_statistics_from_the_virtual_KLF5_knockout_model_in_malignant_ductal_cells_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
Inflammation	CTD Gene-Disease Associations	1.0	1.4612
YD8	DepMap CRISPR Gene Dependency	1.0	3.19312
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.947959
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.08795
GSE137914_0_v_1_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Joubert syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.512
496100621_TCx_probable Alzheimer's disease_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.03903
NFIC	JASPAR Predicted Transcription Factor Targets	1.0	null
MCF7_Temsirolimus_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0271222
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.855955
nervous tissue neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.295523
Rectum adenocarcinoma_READ_TCGA-AH-6897-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Posaconazole_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0175324
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-7022-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intermediate stratum of r8BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0897
lipoproteins	GAD Gene-Disease Associations	1.0	null
ZNF165	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08513
superficial stratum of m2ADL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.7294
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.1351
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Gallic acid (hydrate)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00831238
paraventricular nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.55566
GSE141328_1_v_0_rock2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Baricitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146736
abnormality of the upper urinary tract	GWASdb SNP-Phenotype Associations	1.0	0.130531
Cortical amygdalar area, anterior part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01651
VIIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.852975
Hmx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.2237
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.80576
VZ in midcingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.7301
GSE152432_6_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
posteroventral (inferior) parietal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.823911
GSE218060_7_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8260656-41467_2021_24380_MOESM4_ESM.xlsx-ERG_EZH2-ENHANCED_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
A3KAW	CCLE Cell Line Gene Expression Profiles	1.0	1.83463
Encorafenib_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0156231
principal sensory nucleus of trigeminal nerve, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.90428
GSE216147_0_v_1_rbm20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.892419
PMC4856960-supp_gkv1471_nar-01762-z-2015-File012.xlsx-GO_common_7H-HIF1_chip-Common_elements_in_chip7h_and_chip_hif1_2530_official_gene_symbols_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-302d	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
JVM2	CCLE Cell Line Gene Expression Profiles	-1.0	-2.50235
subbrachial nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30716
VZ in rostral cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04634
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A263-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Obatoclax Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212286
A549_Baricitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213731
Nuclear membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
K562_Pelitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0378424
A549_AMG-900_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020455
Skin	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.870066
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GSE100316_5_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195691
GSE112860_3_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.52901
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.34735
MCF7_Alvespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131151
superficial stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.99663
Lymphoblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.412
LGALS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02409
Lateral reticular nucleus, magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51071
GTEX-UPJH-0126-SM-4IHLL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35379
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UMUC16	DepMap CRISPR Gene Dependency	1.0	9.50645
DUXA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.9647
OCT-x	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE167474_1_v_0_naa40_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_AG-490_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133021
A549_PHA-680632_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206216
TP63	ChEA Transcription Factor Targets	1.0	null
KMS-28BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.13518
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09603
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121498
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MF63	DeepCoverMOA Drug Mechanisms of Action	1.0	0.31
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4173-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Glioma	DisGeNET Gene-Disease Associations	1.0	null
A549_Selisistat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0226961
K562_BMS-536924_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177008
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.16473
microtubule cytoskeleton	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
K562_Flavopiridol HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.027375
arteriosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.366726
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0256
cortex of cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32783
r11 part of spinal trigeminal nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23053
K562_Sorafenib Tosylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159391
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5098-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Decitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01901
Upper respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
non-membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
neoplasm by histology	GWASdb SNP-Phenotype Associations	1.0	0.196166
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.73633
Prostate adenocarcinoma_PRAD_TCGA-EJ-5514-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Glesatinib(MGCD265)_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185593
GSE131377_1_v_0_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_ITSA-1_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156448
OVMANA	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44997
hsa-miR-193b-3p	MiRTarBase microRNA Targets	1.0	null
Pancreas	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.43981
ZNF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42063
SW982	DepMap CRISPR Gene Dependency	1.0	2.9741
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06369
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4117-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MSK2	Kinase Library Serine Threonine Kinome Atlas	1.0	null
orbital frontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.18172
GSE142684_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110178_2_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
mantle zone of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.67564
GSE226249_0_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Imiquimod (hydrochloride)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0169739
MCF7_Bosutinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138385
Busulfan_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00512059
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.60594
solitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.31817
Rectum adenocarcinoma_READ_TCGA-EI-6511-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Retinoic acid_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0198013
GSE180200,GSE180201_12_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OIZI-0126-SM-3NB13	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950713
Mesothelioma_MESO_TCGA-NQ-A57I-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hashimoto Disease	DisGeNET Gene-Disease Associations	1.0	null
A549_ZM 447439_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136553
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.972941
Prostate adenocarcinoma_PRAD_TCGA-CH-5751-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE242049_1_v_0_txndc5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_11_v_3_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U4B1-1526-SM-4DXSL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44426
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.3526
hsa-miR-142-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.205675
GTEX-PLZ6-0726-SM-3P619	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17072
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bed nuclei of the stria terminalis, posterior division, strial extension	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26244
CHK2	Kinase Library Serine Threonine Kinome Atlas	1.0	null
URI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07456
Lumateperone (tosylate)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0243803
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54I-01A-21R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VIIIA	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.89371
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.0979
Perturb_4313_KO_Gata1_SRP059610	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.33678
HOXB4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1968
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perindopril (erbumine)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0167505
CHP-212	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
rheumatoid arthritis	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.256228
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.24735
hsa-miR-137	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
MCF7_Pelitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137147
K562_Tofacitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155357
A549_Fasudil_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0222925
A549_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0269412
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Aster	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.912
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.976523
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32521
MCF7_Momelotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0121051
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-6846-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hypersensitivity reaction type ii disease	GWASdb SNP-Disease Associations	1.0	0.259714
MCF7_AG-490_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162044
CREB1	ChEA Transcription Factor Targets	1.0	null
SNU761	CCLE Cell Line Gene CNV Profiles	-1.0	-1.80703
Perturb_12661_KD_RAB7_SRP017435	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.388
A549_SB431542_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141202
PHGDH_KO_GDS2874_125_mouse_embryonic head tissue	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.847258
GSE138789_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35482
MCF7_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182364
A549_WP1066_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191242
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Lung adenocarcinoma_LUAD_TCGA-55-6987-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7918-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Foxn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.7891
GSE148252_0_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.5833
microtubule cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-XUJ4-1926-SM-4BOOV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846975
layer 1 of VPrP cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02211
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE131649_6_v_0_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NSC735380	DeepCoverMOA Drug Mechanisms of Action	1.0	0.41
HOXB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77154
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.70504
Rectum adenocarcinoma_READ_TCGA-AF-2690-01A-02R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4452	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE225684_0_v_2_tfap4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
HEL9217_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.25491
NB13	DepMap CRISPR Gene Dependency	1.0	2.1357
STAT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1744
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE110248_1_v_6_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
MCF7_Iniparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223523
A549_MK-5108_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158819
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23495
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32208
Oligoasthenoteratozoospermia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
GSE148200_4_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210580_0_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
musculoskeletal system disease	GWASdb SNP-Disease Associations	1.0	0.101498
tonsil_8a1	HPA Tissue Sample Gene Expression Profiles	1.0	1.1602
Lucanthone_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0282623
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00282
SRMS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54682
GTEX-RU1J-1726-SM-2TF5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922328
A549_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0289653
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.933225
GSE154074_2_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Belinostat_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0168231
centriole	GO Cellular Component Annotations 2015	1.0	null
IRF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.9167
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
20220088-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
GTEX-SNMC-1226-SM-2XCFP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851097
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.19214
GSE126463_0_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11169
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Tacedinaline_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0323692
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3X2-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12178829-mmc4.xlsx-Sheet_3-MEG3-KD_Down-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3N5-01A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20049
Dorsomedial nucleus of the hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11396
OPM2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.59576
Thyroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.831573
A549_Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150867
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.928079
DAPK3	Kinase Library Serine Threonine Kinome Atlas	1.0	null
A549_WHI-P154_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0275095
GSE178113,GSE178116_0_v_1_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NR3C1-21868756-MCF10A-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
KAT2A	ENCODE Transcription Factor Targets	1.0	null
PMC6426138__F6	PFOCR Pathway Figure Associations 2023	1.0	null
E2F4_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.079777
GSE206226_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3712
PMC10800016-table_s3_20230913_ddad186.xlsx-DUX4-aff_II-Unnamed_1_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SW1116	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Ciliary rootlet	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.123
GSE227592_10_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lumateperone (tosylate)_SW480	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0298404
Polydactyly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.226
GTEX-S95S-1126-SM-4B64E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29786
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_7A-MAX_KO_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE110178_1_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
lymphoma	GWASdb SNP-Phenotype Associations	1.0	0.599613
A549_G007-LK_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0304905
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4723-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_EED226_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194791
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_2_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
Glomus tumor	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
NCI-H630	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.956193
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7842-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TML8-0526-SM-32QOQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.15176
A549_Fasudil_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01313
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
A549_Fedratinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159684
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5326-01A-01R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Entacapone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152717
PMC9529122-pone.0274785.s002.xlsx-S1_Table-S1A_Table_Differentially_expressed_genes_in_HeyA8_overexpressin_ZNF521_vs_HeyA8_control_cells_ZNF521	Rummagene Transcription Factor Associations 2026	1.0	null
Microtubule organizing center	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Cytarabine (hydrochloride)_SW480	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0214679
MCF7_SNS-314 Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0117772
STAT3-1855785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39829
APTO-253_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00870182
Microtubule cytoskeleton	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.623
SMMLCK	Kinase Library Serine Threonine Kinome Atlas	1.0	null
MCF7_SRT1720 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181561
Piriform-amygdalar area, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37769
GSE172295_1_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ventrolateral preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.90616
Perturb_4342_OE_MIR9/MIR124_SRP271664	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE216147_2_v_3_rbm20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197105
HS822T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.79504
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36896
GTEX-SJXC-1226-SM-4DM78	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04659
ATF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6615
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-1205	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
A549_Navitoclax_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0319377
Perturb_14224_KO_Tcf12_SRP392331	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.99233
GALNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44275
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.862805
Pimitespib_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0118909
GTEX-RU72-0126-SM-2TF6Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48048
GTEX-XLM4-2026-SM-4AT4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.004
r10 part of spinal vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.40053
GTEX-WK11-2526-SM-3NM9Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835899
locus ceruleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.987944
K562_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017688
A549_Vandetanib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151568
MCF7_Lapatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164006
CTCF_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE139239_1_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KINGS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.52712
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.0337
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21749
K562_Ki16425_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192005
PMC11976845-pr4c00864_si_003.xlsx-Data_S2E_HeLa_LF-Unnamed_4_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.956583
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38507
Lung Neoplasms	CTD Gene-Disease Associations	1.0	1.14064
Cell projection membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.323
hsa-miR-4495	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
K562_JQ1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167898
K562_Meprednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167972
ZSCAN21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0486
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37435
MCF7_PHA-680632_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207132
(R)-Verapamil (hydrochloride)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0320803
PMC10769395-media-2.xlsx-S2E_EF_Activated_genes-Ebegboni_et_al_Supplemental_Table_S2E_Decreased_expression_following_depletion_of_EWSR1_FLI1_TC-32_TC-71_and_A673_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7335061-41467_2020_17150_MOESM4_ESM.xlsx-Table_S3-LIN28B_correlates_LIN28B	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P4QT-2626-SM-2I3FM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07475
A549_Danusertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174971
HOXB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0766
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186440,GSE186443_3_v_7_daxx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.642
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HG-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12180985-BLOODA_ADV-2024-014495-mmc1.pdf-29-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160246_9_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mild influenza (H1N1) infection	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.752288
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5109-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A427	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Belinostat_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0230935
Imiquimod	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
nod2_21335489_hek293_lof_human_gpl570_gds4416	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.930996
GTEX-V955-0426-SM-3GAEL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857537
PMC12354803-42003_2025_8643_MOESM2_ESM.xlsx-2w_TP63_positive-Gene_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Raltitrexed_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128842
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48717
GSE148252_0_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
obesity	GWASdb SNP-Disease Associations	1.0	0.789545
Brain Lower Grade Glioma_LGG_TCGA-DB-A4X9-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GC-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0286029
organ system cancer	GWASdb SNP-Disease Associations	1.0	0.163762
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59711
POLR2A_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ML365	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
CPSF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11944
CTNNB1-20460455-HCT116-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-S32W-1326-SM-4AD5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28947
GTEX-PWN1-0126-SM-2I3FK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872127
GSE130217_5_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE207728,GSE207808_2_v_1_c646_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Up_bins-Up_bins_gaining_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182680,GSE182683_0_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXB4-20404135-EML-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE126463_0_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.0788
GTEX-OIZH-2126-SM-3NB1P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77371
K562_Rucaparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.024224
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0835
GTEX-S3XE-0426-SM-3K2AC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02241
SGK1	Kinase Library Serine Threonine Kinome Atlas	1.0	null
GATA1	ENCODE Transcription Factor Targets	1.0	null
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Gene_Name_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.61321
A549_Lenalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0244022
TMA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74786
GTEX-WFG8-1926-SM-4LVM1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12556
MCF7_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156367
8505C	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SU-DHL-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.883564
GSE162623_0_v_1_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
abnormality of taste sensation	GWASdb SNP-Phenotype Associations	1.0	0.502664
K562_Celecoxib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143725
MCF7_WP1066_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168164
Lipoic acid_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0180393
HOXA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8925
LTBR_INHIBITION - 1 Day_GDS2005_728_mouse_Lymph nodes  (MG-430B)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
K562_Raltitrexed_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0277779
cdx2_20696899_caco2_lof_human_gpl570_gse22572	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.003005
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.92054
GTEX-WFON-1726-SM-4LVMQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81144
KDM5B	ENCODE Transcription Factor Targets	1.0	null
HCC1359	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.85667
HCC89	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23177
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8234
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6V9-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HS3ST3B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57667
superficial stratum of p2B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06588
GSE214931_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE224311_3_v_4_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Luminespib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00950059
subparafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15318
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42271
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.900853
GSE215086_1_v_7_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XGQ4-0226-SM-4GIDS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866873
Lateral hypothalamic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1631
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7591-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE203308_7_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Posterolateral visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06004
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.49787
A549_Belinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165364
GSE203308_14_v_5_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PIFO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49177
Brain Lower Grade Glioma_LGG_TCGA-HT-8011-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
p2 portion of the substantia nigra pars reticulata	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06826
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_Temsirolimus_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213063
GSE119978,GSE180930_6_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bed nuclei of the stria terminalis, anterior division, juxtacapsular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03034
Naproxen_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0171051
HAUS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.564
CI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17849
MSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3261
ATXN2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34922
MYC	ENCODE Transcription Factor Targets	1.0	null
type ii diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.504107
TYK-NU.CP-R	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-1193	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
A549_FLLL32_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194731
hsa-miR-1255a	TargetScan Predicted Conserved microRNA Targets	1.0	0.336728
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.41697
A549_Resveratrol_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124462
Idarubicin (hydrochloride)_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0141561
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE125014_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.889688
Hyperthyroidism	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.85
Dapagliflozin ((2S)-1,2-propanediol, hydrate)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0135556
Crus 2, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21719
GTEX-RTLS-2426-SM-46MUO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34254
K562_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157004
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
thyroid_5b	HPA Tissue Sample Gene Expression Profiles	1.0	0.991048
Crus 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13735
III	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.889485
rpmi8226	HPA Cell Line Gene Expression Profiles	1.0	0.892011
Infertility, Female	CTD Gene-Disease Associations	1.0	1.24465
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
liver	HPA Tissue Protein Expression Profiles	-1.0	-0.819063
GSE69869_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X4XY-0626-SM-4E3IN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.97746
A549_GSK J1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168948
GSE144115_2_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139541
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08837
hyperthyroidism	GWASdb SNP-Phenotype Associations	1.0	1.38972
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01501
GTEX-T5JC-0626-SM-3NMA6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1062
A549_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196461
GTEX-RU72-1126-SM-2TF6H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856143
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.925129
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.994651
Nephronophthisis 18	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
GSE193258,GSE193259_9_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ventromedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.45548
TCC-SUP cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.923
CTCF_A549_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.851661
A549_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188431
PMC12315868-Supplemental_Data_S1.xlsx-Supplemental_Data_S1F-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
VSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0116
GSE235066_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Rucaparib_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0314818
GSE209598_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30294
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74434
A549_ZM 447439_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018939
DMRTA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2321
Nevirapine_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0245231
GSE169205_3_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE109530,GSE109531_1_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Irinotecan_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0201563
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Divalproex Sodium_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0280983
GSE168401_2_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Alendronate sodium trihydrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015109
A549_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153692
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47066
Perturb_12970_KO_PRMT7_SRP342313	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE218060_2_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_EED226_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0537685
SMC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33205
hsa-miR-433	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.45265
Sarcoma_SARC_TCGA-WK-A8XQ-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mecom	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.4444
A549_Fulvestrant_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187305
disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.256228
neoplasm by anatomical site	GWASdb SNP-Phenotype Associations	1.0	0.188788
Kinocilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.616
PKACG	Kinase Library Serine Threonine Kinome Atlas	1.0	null
MCF7_AZD1480_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170902
POU2F2	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE140441_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE147662_3_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3500769-srep00875-s3.xls-PAX2-Time_0_PAX2	Rummagene Transcription Factor Associations 2026	1.0	null
NOS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16444
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H650	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-O5YT-1026-SM-3MJGF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853279
GSE223008_9_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Trichostatin A_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0299169
AZD-7648_LS 180	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0120571
r8 part of lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2525
Prostate adenocarcinoma_PRAD_TCGA-EJ-5518-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MID1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15111
MCF7_Danusertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136336
abnormality of circulating fibrinogen	GWASdb SNP-Phenotype Associations	1.0	0.770746
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
terminal paraventricular area of THyA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18406
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.943498
NCI-H1581	COSMIC Cell Line Gene Mutation Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01477
periventricular stratum of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11799
NCIH1651	CCLE Cell Line Gene CNV Profiles	-1.0	-2.3514
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Cytoskeleton	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.623
NCIH1975	CCLE Cell Line Gene CNV Profiles	1.0	1.75516
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
nr2c2_20864514_liver_1yo_lof_mouse_gpl4134_gse21903	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.01204
GTEX-W5X1-0426-SM-3GILB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06786
Penicillin allergy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.26
SARS-CoV MA15_Day4-PFU-10^3_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.95383
Centriole	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
A549_MC1568_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0229376
morphological abnormality of the central nervous system	GWASdb SNP-Phenotype Associations	1.0	0.1317
GSE242049_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormal joint morphology	GWASdb SNP-Phenotype Associations	1.0	0.230696
GSE136238_1_v_2_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S7PM-0526-SM-3NM92	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00809
PMC3500769-srep00875-s3.xls-AP1-Time_1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
periventricular stratum of PcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.41163
H3K79me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Breast_Myoepithelial_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.01256
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247553
core of P-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.65747
plexiform layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80419
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4696-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-520d-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Perturb_6584_KO_Clpp_SRP114840	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.87337
K562_Capecitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0256323
Perturb_3146_KO_Mrfta/Mrtfb/Myocd_SRP388810	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.20611
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4697-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Presubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32191
HCC4006	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.18843
A549_PHA-680632_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0304091
GSE173262_6_v_0_ash1l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH650	DepMap CRISPR Gene Dependency	1.0	5.60435
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868167
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.869923
EIF3M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48352
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_12Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.50154
PKG1	Kinase Library Serine Threonine Kinome Atlas	1.0	null
MCF7_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133172
Lung squamous cell carcinoma_LUSC_TCGA-85-A50M-01A-21R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Axonemal microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.508
A549_G007-LK_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01698
GSE160817_7_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20901
A549_MC1568_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198129
A549_Hesperadin_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136688
GSE96641_5_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
GSE198254_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QDVJ-1226-SM-48U1V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.906001
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.99185
GSE153189_1_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Spermatogenic failure 16	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.736
Manchette	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.27
GTEX-POYW-0008-SM-48TE4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24182
Nr1h3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.2227
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11291
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08484
PMC11876052-DataSheet2.xlsx-Endo2-GATA3_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
Epirubicin (hydrochloride)_SW480	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0196992
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.076
MCF7_Trichostatin A_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214905
EHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3403
HOXC8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5106
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-6028-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08144
A549_Crizotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0291491
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73231
A549_2-Methoxyestradiol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131739
MCF7_Decitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180861
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30187
GSE192663_3_v_5_acly_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lateral ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.868951
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.990942
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-139-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
r6 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20195
fulvestrant_homo sapiens_gpl570_gse22533	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lipid metabolism disorder	GWASdb SNP-Disease Associations	1.0	0.789545
Radial spoke	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.186
superficial stratum of PPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37339
SCC4	CCLE Cell Line Gene CNV Profiles	1.0	1.8856
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.59321
rostral division of VL	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28913
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC13127299-mmc2.xlsx-FOXM1_kdRNAseq-hgnc_symbol_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
Orbital area, medial part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50533
HS819T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.72672
A549_Bisindolylmaleimide IX_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0223735
daudi	HPA Cell Line Gene Expression Profiles	1.0	0.983142
SPI1	ChEA Transcription Factor Targets	1.0	null
thyroid gland disease	GWASdb SNP-Disease Associations	1.0	0.372205
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZS-06A-12R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE186223,GSE186224_6_v_3_hmces_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MXI1	ENCODE Transcription Factor Targets	1.0	null
Lipoic acid_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.031588
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2M5-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WL46-3026-SM-3LK7Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840363
GTEX-RM2N-0008-SM-48FF3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11055
r7 part of the dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48597
MCF7_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162446
GTEX-WFG8-2226-SM-3GIL9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12755
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7923-01A-12R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_TAK-901_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208322
GTEX-PVOW-0126-SM-2XCFA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1205
NCI-H2228	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.855775
GSE110178_4_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Anagrelide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the breast	GWASdb SNP-Phenotype Associations	1.0	0.379543
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_y_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.992995
polymorphic layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.836518
MZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.950407
IZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02811
GTEX-XXEK-0726-SM-4BRWF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50306
A549_FLLL32_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0327926
H3118	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CA4 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11055
MCF7_MK-5108_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210653
TFCP2L1	ChEA Transcription Factor Targets	1.0	null
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5921
SNU1076	CCLE Cell Line Gene CNV Profiles	1.0	1.36413
KMS-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.84932
Pyridoxine_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0202774
A549_Aurora A Inhibitor I_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143571
GSE152432_5_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0917
GSE160817_0_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223008_5_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16181
GTEX-R45C-0926-SM-3GAD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0228
A253	COSMIC Cell Line Gene Mutation Profiles	1.0	null
JIYOYE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14075
Perturb_7259_KD_EP300_SRP193326	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_SRT3025 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167936
GSE48812_2_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_2036_KO_Nrf2_SRP408559	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	18.1367
PMC9038526-mmc1.xlsx-healthy_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Entinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141197
Orofaciodigital syndrome IX	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.488
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUP-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_2-Methoxyestradiol_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196781
SRF_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPK5-1126-SM-3GAEJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927935
KAT2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleus of diagonal band	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.852212
GTEX-TKQ2-1526-SM-4DXUN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61212
GTEX-X4EO-0926-SM-3P5Z2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91144
hsa-miR-612	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
mRNA_NIPBL_20720539	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
A549_INO-1001_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187027
b-cell lymphoma	GWASdb SNP-Disease Associations	1.0	0.442605
Fetal_Intestine_Large	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.39342
GSE103068_0_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S95S-0226-SM-4B656	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825328
ESR1	ChEA Transcription Factor Targets	1.0	null
A549_GSK-LSD1 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138862
r4 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25823
GSE88819_1_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X4XY-0826-SM-4E3JM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21581
GSE100732,GSE100733_0_v_1_lrpprc_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MN-01A-22R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSK1059615_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0233573
PMC3906982-1471-2164-14-830-S1.xlsx-Sheet1-Table_S1_HOXC9-responsive_genes_HOXC9	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YI-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_MC1568_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0247627
JHOM1	CCLE Cell Line Gene CNV Profiles	1.0	1.41332
ctv1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.598
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.92359
klf5_18983969_embryonic_stem_cell_lof_mouse_gpl1261_gds3509	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.707161
centriole	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Perturb_12854_KD_Pdx1_SRP149543	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00356
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.51047
MINDY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27199
A549_Trichostatin A_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0258143
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.958121
hsa-miR-27a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hmx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.0195
UBXN2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49047
Gastric epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.881
GSE149355_0_v_1_esrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pyridoxine (hydrochloride)_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0205495
medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.844351
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Berbamine_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0326072
DOHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17347
GTEX-PW2O-1426-SM-48TCD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17369
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.07365
GSE213588_8_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE110178_5_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Mocetinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0213791
HS 255.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.52003
ULK-101_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00853169
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TX-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Glesatinib(MGCD265)_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144737
GTEX-W5X1-2826-SM-3GILM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88301
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42006
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17957
prostate_4b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.922142
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE235701,GSE261434_0_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015221
EIF4ENIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43799
K562_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0223279
microtubule organizing center	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
NR3C1	ChEA Transcription Factor Targets	1.0	null
MCF7_Tie2 kinase inhibitor_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154531
GSE166920_6_v_4_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Joubert syndrome 23	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
A549_Alendronate sodium trihydrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0458823
TFAP2A-17053090-MCF7-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
testis_7d	HPA Tissue Sample Gene Expression Profiles	1.0	1.34481
DU4475	CCLE Cell Line Gene CNV Profiles	-1.0	-2.09845
GTEX-XUJ4-1726-SM-4BONW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.862615
K562_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015926
PMC12178937-mmc6.xlsx-D_MAFF_KDvsD_C_deg_all-gene_name_MAFF	Rummagene Transcription Factor Associations 2026	1.0	null
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02729
Spermatozoon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.425
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7236
hypothalamus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.938514
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4890-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_SNS-314 Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0220849
GTEX-P4QS-1026-SM-3NMCW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02894
P30-OHK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE174498,GSE174500_3_v_4_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02829
A549_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207208
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4688-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE247862,GSE247863_4_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8891017-41586_2022_4394_MOESM4_ESM.xlsx-ST6_-_MAF_enrichment-Unnamed_4_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE113329,GSE113335_2_v_4_taf6l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Daptomycin_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0181614
GSE111247_14_v_10_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S33H-0126-SM-4AD62	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1823
GTEX-QDVN-2026-SM-3GAEP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836623
GSE112995,GSE132079_1_v_3_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE115363_2_v_4_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BA-46-YF32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202291
Hyperplasia	CTD Gene-Disease Associations	1.0	1.14473
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-TSE9-0626-SM-3DB8B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40098
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17934
GTEX-UJHI-1726-SM-3DB9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870946
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-520g	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66302
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.31782
TAK-733_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0162427
abnormality of cells of the erythroid lineage	GWASdb SNP-Phenotype Associations	1.0	0.281419
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_10604_KO_Ncor1_SRP216477	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.73717
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_Jurkat_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB1-F2del_3Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.53903
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10435
hypertension	GWASdb SNP-Disease Associations	1.0	0.727764
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lhx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	85.25
spindle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63321
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.857563
abnormality of cardiovascular system physiology	GWASdb SNP-Phenotype Associations	1.0	0.627321
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RAF1	Kinase Library Serine Threonine Kinome Atlas	1.0	null
A549_SRT2104_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140479
GTEX-PLZ5-0626-SM-2I5F8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11305
GTEX-PLZ5-1526-SM-3P5ZX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872737
Lymphocyte	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_TGX-221_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167046
PMC10641274-mmc2.xlsx-FOXK1_Insulin-ENSEMBL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3500769-srep00875-s3.xls-CEBP-Time_1_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
abnormality of the lung	GWASdb SNP-Phenotype Associations	1.0	0.518575
COR-L26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01611
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.847258
A549_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174148
KNS81	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39373
VN(H5N1)_12hour_None_GSE37245	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.83138
FOS	ENCODE Transcription Factor Targets	1.0	null
Everolimus_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0144107
GSE213228_4_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
pallidal islands of Calleja	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17751
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31433
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.19109
C32	DepMap CRISPR Gene Dependency	1.0	3.45296
Vortioxetine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.013229
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PRXL2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08766
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02922
GTEX-RWSA-2426-SM-47JXR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56146
CP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00763
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.875505
Sarcoma_SARC_TCGA-LI-A9QH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188168
A549_AT9283_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159058
DU-145	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55D-0126-SM-48FEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25204
KMBC2	CCLE Cell Line Gene CNV Profiles	1.0	1.33648
icSARS CoV_7Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	4.81361
GSE147662_2_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0784
GTEX-U8XE-1126-SM-3DB8W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.918057
Lung adenocarcinoma_LUAD_TCGA-69-A59K-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9794_KD_FOXO3_SRP325840	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.3758
abnormality of the oral cavity	GWASdb SNP-Phenotype Associations	1.0	0.141392
CHSA8926	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC6828764-41419_2019_2062_MOESM2_ESM.xlsx-GATA3_UTX_promoter_gene-Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WCDI-0002-SM-3P61U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20099
GTEX-OOBJ-0926-SM-48TDO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82561
RPMI7951_SKIN	CCLE Cell Line Proteomics	1.0	3.48627
GTEX-XBED-2026-SM-4AT5D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76507
GSE255432_6_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10771438-41598_2023_51082_MOESM1_ESM.xlsx-Day21-Supplementary_Dataset_1_List_of_genes_differentially_expressed_during_NS_PC_differentiation_between_ROR2_KD_cells_and_control_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_7_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T8EM-0126-SM-4DM5R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90663
GSE153189_2_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.18172
Lung squamous cell carcinoma_LUSC_TCGA-O2-A5IB-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7736-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
genital neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.260489
Vinblastine (sulfate)_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0189892
K562_S-Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150484
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.40406
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00035
GSE146074_9_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE136238_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_G007-LK_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188675
periventricular stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46192
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Retinoic acid_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00424348
PDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.8215
GSE210682_0_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-96-HO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210494
A549_JNJ-26854165_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0266621
A549_BMS-911543_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146614
HOXB5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2349
A549_BRD4770_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171217
A549_Raltitrexed_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214785
A549_Triamcinolone Acetonide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0107294
A549_Aurora A Inhibitor I_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0238635
Trametinib (DMSO_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0280282
GSE182680,GSE182683_5_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE152666,GSE152668_2_v_1_carm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4989-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_SGI-1776 free base_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194794
A549_RG108_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013249
FOXA2	ChEA Transcription Factor Targets	1.0	null
GTEX-N7MS-2326-SM-2HMLD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871921
hsa-miR-340	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
GSK1059615_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0326009
GSE237040_6_v_3_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE122509,GSE122513_2_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22239
GSE147662_2_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Panobinostat_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0160715
K562_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144623
K562_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0251629
ATP6AP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17227
MEWO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-XQ8I-0626-SM-4BOPT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864117
GSE182680,GSE182683_10_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ULK1_knockout_197_GSE60778	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.43841
KINGS1	DepMap CRISPR Gene Dependency	1.0	4.10743
A172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33132
PMC10534007-Table_3.xlsx-S8_unique_down_MSC_V_2-345_elements_included_exclusively_in_VMCUB1_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
r5 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46148
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24709
SARS-CoV MA15_Day4-PFU-10^4_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.2333
GTEX-U8XE-0926-SM-3DB8V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.860954
MPF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.682
K562_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168946
GSE171837_0_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Iniparib_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01606
Cilium	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
AMO1	CCLE Cell Line Gene Expression Profiles	1.0	1.47692
ARID3A	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66254
GSE123825_0_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.56048
CREB1-23762244-HIPPOCAMPUS-RAT	ChEA Transcription Factor Binding Site Profiles	1.0	null
BE2M17	DepMap CRISPR Gene Dependency	1.0	3.88775
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.05162
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.51315
KH7	DeepCoverMOA Drug Mechanisms of Action	1.0	0.53
GTEX-NFK9-0626-SM-2HMIV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04963
A-498	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.853178
posteroventral (inferior) parietal cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.995468
GSE139455_2_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.21556
Uterine Carcinosarcoma_UCS_TCGA-N8-A4PN-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hypothalamic lateral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11139
PF382	CCLE Cell Line Gene Expression Profiles	1.0	1.88065
16141321-Table2	GeneSigDB Published Gene Signatures	1.0	null
ZNF680	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.6793
MCF7_Gandotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146724
MCF7_Hesperadin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167828
MCF7_Tubastatin A HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171459
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76745
GSE146546,GSE146807_0_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PANC0813	CCLE Cell Line Gene CNV Profiles	1.0	2.19146
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.976108
A549_BMS-754807_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200286
mantle zone of r8BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10892
hsa-miR-520d-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.336728
GTEX-O5YT-2126-SM-3MJGD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10027
A549_RG108_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161883
GSE213588_10_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lingula (I)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34433
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17957
Posterior hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17009
PMC3371315-NIHMS350140-supplement-8.xls-MCF7-T47D-SK-453_Down_MCF7-T47D-Supplementary_Table_1_ER-positive_FOXA1_signature_Genes_decreased_only_in_MCF7_and_T47D_cells_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE88819_7_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10037107-JEM_20221755_TableS6.docx-0-IL4-p_D419G-STAT6_targets_in_Jurkats_1_STAT6	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Mesna_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147504
GTEX-TMMY-1326-SM-4DXU9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1337
r11 part of the trigeminal column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23188
primary motor cortex (area M1, area 4)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1256
NUGC4	CCLE Cell Line Gene Expression Profiles	-1.0	-2.53226
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27308
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.222
G84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10774
GSE128232,GSE128233_1_v_0_phf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23455
GSE110178_2_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Cerdulatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0377288
hsa-miR-4756-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
hsa-miR-4259	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GSE110440_1_v_3_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6404-02A-21R-A36H-07,TCGA-DU-6404-02B-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-891b	TargetScan Predicted Conserved microRNA Targets	1.0	0.219115
PU.1	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE189789_0_v_1_oridonin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Gandotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167025
Docetaxel_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0251482
K562_Lomustine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016348
PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1c-List_of_1682_genes_differentially_regulated_by_GLI1_FDR_0_1_GLI1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0313366
hippocampus (hippocampal formation)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.893097
GSE135352_6_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_BMS-536924_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0292478
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908925
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3B7-01A-31R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2912-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19023
Parataenial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03395
Phosphoribosylaminoimidazole carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.787
TK-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.887441
GTEX-N7MS-0126-SM-3TW8O	GTEx Tissue Sample Gene Expression Profiles	1.0	2.39317
NCIH1993	DepMap CRISPR Gene Dependency	1.0	2.9024
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RM-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
neoplasm of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.260489
periventricular stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48512
hsa-miR-4791	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
K562_Selisistat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178733
mediodorsal nucleus of thalamus_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.288
GSE147662_0_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Glesatinib(MGCD265)_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0244224
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04081
CTNNB1	ChEA Transcription Factor Targets	1.0	null
GTEX-XUZC-2026-SM-4BRW9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849677
GSE124932_2_v_1_sarm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Sarcoma_SARC_TCGA-DX-A1L0-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Linifanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023043
A549_Barasertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147732
Sarcoma_SARC_TCGA-QQ-A8VH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S32W-1926-SM-4AD63	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17859
A-498	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.983813
A549_Azacitidine_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0121023
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13252
GTEX-SUCS-1426-SM-4DM5W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851536
GTEX-QLQW-1026-SM-447A9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55804
dementia	GWASdb SNP-Disease Associations	1.0	0.3207
GSE179880_1_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160442,GSE160444_4_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H1435	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2990-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FBXL16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25334
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.06351
Acute Myeloid Leukemia_LAML_TCGA-AB-2976-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE212312_2_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	1.0	null
abnormality of the genital system	GWASdb SNP-Phenotype Associations	1.0	0.097062
Busulfan_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0200369
A549_Nilotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183054
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213588_8_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
BML-277	DeepCoverMOA Drug Mechanisms of Action	1.0	0.62
GTEX-Q2AG-0426-SM-2S1PU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838478
NCIH2196	CCLE Cell Line Gene CNV Profiles	1.0	1.39602
GSE110708_1_v_3_adar_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Irinotecan_SW480	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0351528
GSE58724_3_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
perifornical nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.53429
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MCF7_Fedratinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179252
GSE123825_2_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EOMES_OE_GDS5077_65_human_RUES2	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08165
GSE111247_0_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Larotrectinib sulfate_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0232673
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RL-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
brain_3c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.13298
organelle	GO Cellular Component Annotations 2015	1.0	null
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1878
A549_Alisertib_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129512
POLR2AphosphoS5_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-513b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE162087_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06787
A549_Hesperadin_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0112313
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6848-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Thymus-plasma cell	Tabula Sapiens Gene-Cell Associations	1.0	10.4095
GTEx Thyroid 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	6.50753
GSE178714_3_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WYJK-1626-SM-3NM9J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2542
Sperm flagellum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.719
K562_Abexinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018548
K562_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198876
Anteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21719
abnormality of the head	GWASdb SNP-Phenotype Associations	1.0	0.082771
GSE211128_4_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Daphnetin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0225577
hsa-miR-3140-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.336728
Perturb_14089_KO_SMARCA2_SRP295674	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Hedgehog signaling complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.757
A549_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213188
DICER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14703
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.956254
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SE5C-0426-SM-4BRUI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10446
A549_Tozasertib_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164884
Prostate adenocarcinoma_PRAD_TCGA-CH-5765-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE179002_3_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_0_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
pontobulbar body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.942583
S-Adenosyl-L-methionine (disulfate tosylate)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0177652
H-1152	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
RMGI	CCLE Cell Line Gene Expression Profiles	-1.0	-2.09481
PMC6684323-NIHMS1532201-supplement-Table_S6.xlsx-LPS-Sup_Table_6C_Delta_PVE_among_PopDE_genes_LPS_PopDE_FDR_0_2_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
DETROIT562_UPPER_AERODIGESTIVE_TRACT	CCLE Cell Line Proteomics	1.0	2.22096
A549_Celecoxib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155008
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-1255b	TargetScan Predicted Conserved microRNA Targets	1.0	0.32519
Esrrg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.337
Trifluridine_SW480	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0208042
A549_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0243212
GTEX-RVPU-0011-R1A-SM-2XCAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839978
posterior (caudal) superior temporal cortex (area 22c)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.39953
GTEX-XGQ4-2026-SM-4AT6G	GTEx Tissue Sample Gene Expression Profiles	1.0	2.17578
Lung squamous cell carcinoma_LUSC_TCGA-22-5489-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE118794_2_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239844_8_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.01324
SK-MES-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MZ in dorsomedial parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.893134
intracellular non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.94103
GTEX-U3ZH-1526-SM-4DXV1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18765
GSE152432_3_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839073
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09099
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.155
PMC10591879-NIHMS1933918-supplement-2.xlsx-Down_in_NMR_OPC_differentiation-EGR1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
C2orf69	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53198
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8586
Pachytene cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.221
GSE215086_4_v_7_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111660_4_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SU8686_PANCREAS	CCLE Cell Line Proteomics	1.0	4.78775
posteroventral (inferior) parietal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.980908
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE147834_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02671
BT-483	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.70962
nucleus of the inferior collicular brachium, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.61051
Simple lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17088
COMMD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07168
Trimetrexate_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0230236
glioblastoma	GWASdb SNP-Phenotype Associations	1.0	0.599613
GSE196259_2_v_0_gcm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Tucidinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018975
CA1 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.981864
PANC-08-13	COSMIC Cell Line Gene CNV Profiles	1.0	2.10038
GSE153189_2_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
sknep1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.624
GBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9165
GSE131649_6_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Thymidine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.54
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12796
Vinblastine (sulfate)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0271943
CEBPA	ChEA Transcription Factor Targets	1.0	null
GTEX-S7PM-0626-SM-4AD4Q	GTEx Tissue Sample Gene Expression Profiles	1.0	2.0852
GSE178340_1_v_6_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192466
GSE224311_3_v_1_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
cardiovascular	GAD High Level Gene-Disease Associations	1.0	0.298214
OCILY19	DepMap CRISPR Gene Dependency	1.0	2.3194
Autism	DisGeNET Gene-Phenotype Associations	1.0	null
GSE146074_6_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.2409
GTEX-WHPG-0226-SM-3NMB9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897094
MCF7_Alendronate sodium trihydrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163852
GSE88819_1_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148066,GSE157787_8_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TT2609-C02	COSMIC Cell Line Gene Mutation Profiles	1.0	null
lateral preoptic nucleus, PO2 part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.81961
PMC8528285-pbio.3001085.s010.xlsx-Fig_S8E-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_KO_3T3_ONLY_2084_GENES_MNT	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF211	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6814
GTEX-P4QS-1126-SM-3NMD5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.982593
GTEX-X3Y1-0726-SM-3P5YU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03498
GTEX-UPK5-1426-SM-4JBHH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14185
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07143
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.273
G402	DepMap CRISPR Gene Dependency	1.0	2.62273
ChIP_STAT3_19079543	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
neurodegenerative disease	GWASdb SNP-Disease Associations	1.0	0.225969
A549_Ki16425_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0246666
K562_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154688
r7 part of cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18337
Prostate adenocarcinoma_PRAD_TCGA-XQ-A8TA-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.887515
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XO-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EB-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.934
hsa-miR-4650-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
MCF7_Fulvestrant_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215299
HELA	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.898492
Edinger-Westphal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.31006
PMC12663032-mmc7.xlsx-Supp_T6-Supplemental_Table_6_Dual_treated_vs_vehicle_treated_MSC_top_DEGs_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11589
GTEX-R3RS-0726-SM-3GIJR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32629
shell of P-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.282
hsa-miR-520h	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GSE131161_5_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.7926
Erythroleukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RERFLCMS_LUNG	CCLE Cell Line Proteomics	1.0	3.71285
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_CCRFCEM_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147626_3_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsal motor nucleus of the vagus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.881022
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MU-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LN443	CCLE Cell Line Gene CNV Profiles	1.0	1.34237
central nervous system disease	GWASdb SNP-Disease Associations	1.0	0.077753
beta-lactam allergy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.218
GSE188458_2_v_1_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XXEK-1726-SM-4BRVB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12938
GTEX-QDVN-0826-SM-48TZ2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926053
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5374-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Droxinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238472
GSE95077_5_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Barasertib_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182285
Implantation fossa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.28
GSE88819_0_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Danusertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189926
K562_Nintedanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139996
A549_Tranylcypromine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141111
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.155
Kidney renal papillary cell carcinoma_KIRP_TCGA-WN-A9G9-01A-12R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE192689_0_v_2_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Regorafenib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159365
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_9820_KD_LMO1_SRP103740	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.55325
Infralimbic area, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10127
microtubule organizing center	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Retinoic acid_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.03716
Perturb_15422_KD_PXN_SRP199368	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.65321
HI-TOPK-032_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0298706
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.85031
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WG-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6940_KO_Rbm20_SRP403612	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-19.2218
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.42037
GTEX-O5YW-0326-SM-2I5EI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50325
Lateral septal nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0862
Lung squamous cell carcinoma_LUSC_TCGA-43-A56U-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE183327,GSE183328_1_v_0_ddit3_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184798
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE182680,GSE182683_5_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Abexinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0114279
K562_Tacedinaline_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146065
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00877
K562_A-366_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157516
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the tongue	GWASdb SNP-Phenotype Associations	1.0	0.502664
Perturb_9807_OE_EBF4_SRP381947	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE145628,GSE145629_1_v_0_myrf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Divalproex Sodium_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0225429
posteromedial visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3617
GSE215351,GSE215794_1_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203181_0_v_1_phosphoramidon_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33915
GSE242367_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.12759
GSE126402_4_v_0_tal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE188458_2_v_3_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Subparafascicular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.88275
MCF7_Tofacitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138073
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.877397
GTEX-U3ZN-2326-SM-3DB7W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05787
HGC27	CCLE Cell Line Gene CNV Profiles	1.0	1.37689
A549_PF-3845_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0233204
superficial stratum of Ist	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36384
MM383	DepMap CRISPR Gene Dependency	1.0	3.70386
parabigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.35305
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
ventrolateral prefrontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.846398
Erlotinib_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0130597
Ikzf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.3593
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
SCC-25	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.872202
MCF7_MLN8054_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199629
hypersensitivity reaction disease	GWASdb SNP-Disease Associations	1.0	0.233265
renal cell carcinoma	GWASdb SNP-Phenotype Associations	1.0	0.599613
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.931434
Perturb_9138_KD_SNAI1_SRP133893	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.68403
Ciliary base	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.897
Perturb_4307_KO_FOXM1_SRP328179	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
locus ceruleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.44362
abnormality of the cardiovascular system	GWASdb SNP-Phenotype Associations	1.0	0.107535
Spleen-plasma cell	Tabula Sapiens Gene-Cell Associations	1.0	11.1151
Retrosplenial area, dorsal part, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36437
TMEM200B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01346
NCIH3255	CCLE Cell Line Gene CNV Profiles	1.0	1.67078
Retinitis pigmentosa 54	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.19718
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49337
NANOG	ChEA Transcription Factor Targets	1.0	null
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Poisoning	CTD Gene-Disease Associations	1.0	1.72717
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lateral part of r8B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11377
A549_AR-42_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127292
hsa-miR-373	TargetScan Predicted Conserved microRNA Targets	1.0	0.404082
Lung squamous cell carcinoma_LUSC_TCGA-60-2703-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inner SZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.957554
Spermatogenic failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.409
KE-37 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.078
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MI-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sinomenine_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0188848
GTEX-S33H-1626-SM-4AD68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80529
GSE164874_5_v_14_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158632_2_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
Aliskiren_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0253769
sirolimus_mus musculus_gpl1261_gse5332	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-6690-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
periventricular part of StrSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27199
GTEX-Q734-0226-SM-48U1A	GTEx Tissue Sample Gene Expression Profiles	1.0	2.25689
superficial stratum of p3B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32645
NCI-H2172	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Naproxen_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0341366
HSF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.1889
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5637 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.902
amygdaloid complex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.994822
A549_Resveratrol_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232649
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30195
Almonertinib (hydrochloride)_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0149079
LCLC-103H	COSMIC Cell Line Gene Mutation Profiles	1.0	null
abnormality of the coagulation cascade	GWASdb SNP-Phenotype Associations	1.0	0.253335
GTEX-T6MN-2026-SM-4DM7L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53665
GTEX-U3ZN-0326-SM-3DB86	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846447
A549_PHA-680632_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0269828
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965908
GSE141328_3_v_2_rock2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE117730,GSE117732_0_v_2_apobec2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.48962
LHX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1132
CDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9699
abnormality of the urinary system	GWASdb SNP-Phenotype Associations	1.0	0.106398
K562_Toremifene Citrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150875
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016353
Perturb_3901_KD_CTNNB1_SRP314475	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
TUBB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48442
PMC11462941-CAS-115-2947-s001.pdf-62-PAX6_PAX6	Rummagene Transcription Factor Associations 2026	1.0	null
medial subdivision of central nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3515
GSE142684_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
respiratory system cancer	GWASdb SNP-Disease Associations	1.0	0.383096
GSE195582_3_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.964436
PMC4595011-pgen.1005555.s001.xlsx-MITF_DOWN-regulated-Ensembl_gene_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_11160_KO_Atp7b_SRP100615	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.55525
GTEX-QESD-0526-SM-2I5G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41148
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_EED226_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015206
HOXB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6695
PMC10794847-mmc5.xlsx-PIAS1_KD_down-Table_S4_Differentially_expressed_genes_with_PIAS1_knockdown_in_the_progenitors_state_Related_to_Figure_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Raltitrexed_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0279998
GTEX-VJWN-0126-SM-3GIK7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43141
MCF7_AG-490_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0322482
teratozoospermia	MGI Mouse Phenotype Associations 2023	1.0	null
GSE168697_0_v_1_wdr6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-R53T-0326-SM-48FEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09321
MCF7_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0276055
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
dorsal tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.60504
K562_AG-490_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158206
Retinal pigment epithelium cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.065
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17712
A549_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0237707
mantle zone of m1AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02819
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01494
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_9819_KD_HEB_SRP103740	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.7974
A549_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0397387
Tolcapone_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0190725
GSE165682_4_v_3_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.47524
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-A5C4-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Cimetidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210635
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
A549_CYC116_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152947
Brain Lower Grade Glioma_LGG_TCGA-HT-7469-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO680N	CCLE Cell Line Gene CNV Profiles	1.0	1.69444
Centriolar subdistal appendage	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Bimatoprost_NCI-H23	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0173965
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10591
A549_Ofloxacin_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168892
GSE228181_3_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-QA-A7B7-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154246
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.41
GTEX-VJWN-0726-SM-3GIJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08695
Centrosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4686
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0556
abnormality of female internal genitalia	GWASdb SNP-Phenotype Associations	1.0	0.168805
K562_G007-LK_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177731
karpas707	HPA Cell Line Gene Expression Profiles	1.0	1.38034
Pralsetinib_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0245145
GSE85565_1_v_0_tcf21_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-3187-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Perturb_234_KD_MITF_SRP048577	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.6045
GTEX-P4QS-2126-SM-3NMCF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09846
GTEX-W5X1-2326-SM-3GIL6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18969
A549_Ellagic acid_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132102
GSE111385_0_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H2596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.907214
K562_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0221924
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Divalproex Sodium_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145604
Perturb_8845_KD_PPARGC1B_SRP254908	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE200673,GSE200691_1_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RBL-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.693
PMC8914074-Table1.XLSX-S8-Alternative_splicing_events_from_corneal_epithelial_samples_and_peripheral_blood_samples_of_KTCN_patients_VSX1	Rummagene Transcription Factor Associations 2026	1.0	null
NOTO	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7087
Posterior parietal association areas, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.65984
A549_Lapatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153267
primary visual cortex (striate cortex, area V1/17)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.937964
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6471-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TKQ1-0926-SM-4DXU2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49377
MCF7_Divalproex Sodium_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159165
mantle zone of m2AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.85928
GSE178714_6_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190235_0_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014451
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864636
Raltitrexed_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0107038
A549_Tozasertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0220578
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46971
HS 675.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.36791
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Magnocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66648
GTEX-U8T8-1126-SM-4DXUE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64225
hsa-miR-520c-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.336728
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Fat-mesenchymal stem cell	Tabula Sapiens Gene-Cell Associations	1.0	3.65823
Perturb_7093_OE_Ppp3cc_SRP310497	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.1821
19218430-TableS3	GeneSigDB Published Gene Signatures	1.0	null
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XOTO-0011-R3A-SM-4B64W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01698
GSE119978,GSE180930_6_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OHPN-0011-R3A-SM-2I5FC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.904371
cone-rod dystrophy 20	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.433
MCF7_Raltitrexed_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150616
A549_JQ1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146624
hsa-miR-378g	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Substantia nigra, reticular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12989
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Medial temporal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.753
AP-4	MotifMap Predicted Transcription Factor Targets	1.0	null
abnormality of the mouth	GWASdb SNP-Phenotype Associations	1.0	0.131669
GSE165548_2_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BATF	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-375	MiRTarBase microRNA Targets	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EC-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.92613
GSE126463_0_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.46967
A549_AZ 960_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0279027
A549_Ellagic acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153957
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36361
A549_SB431542_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018233
Balsalazide (sodium hydrate)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0199772
RCC10RGB	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55803
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20O-01A-21R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61532
GSE71100_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8616957-41467_2021_27270_MOESM4_ESM.xlsx-Sheet1-Supplementary_Data_1_Differentially_expressed_genes_FDR_0_05_edgeR_exact_test_in_MLL-AF4_infant-ALL_vs_MLL-AF4_childhood-ALL_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.46493
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6942-01A-21R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HNRNPAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14102
hsa-miR-4684-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
neoplasm of the lung	GWASdb SNP-Phenotype Associations	1.0	0.599613
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
MCF7_Raltitrexed_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187926
PMC5651844-41467_2017_1173_MOESM5_ESM.xlsx-Down_genes_shY2-1-Supplementary_Data_1_Down_regulated_genes_in_ShY2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Influenza A	DisGeNET Gene-Disease Associations	1.0	null
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NKX6-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0846
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6SW-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HS-578-T	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC10274745-media-4.xlsx-S3B-Table_S3_Reanalysis_of_publicly_available_data_to_identify_AR_and_ER_direct_target_genes_related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889573
GSE132369,GSE132371_4_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Olfactory tubercle, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25524
abnormality of the coronary arteries	GWASdb SNP-Phenotype Associations	1.0	0.317904
endocrine system disease	GWASdb SNP-Disease Associations	1.0	0.274732
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5162-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-62-A46S-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213588_9_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE184902_3_v_1_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.63712
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.69358
HCC4006	CCLE Cell Line Gene CNV Profiles	1.0	2.15108
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
arthritis	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.256228
periventricular stratum of PcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.99894
GSE130217_0_v_2_sesn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146687_2_v_6_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Nilotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0302828
CW-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
LBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2948
GSE179974_3_v_2_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41651
GSE198165,GSE198166_7_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F7-01A-11R-A084-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE228430_1_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00356
JEKO-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCIH2291	DepMap CRISPR Gene Dependency	1.0	3.88865
Rectum adenocarcinoma_READ_TCGA-EI-6508-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.956254
primary auditory cortex (core)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.54824
PMC11073972-41375_2024_2232_MOESM2_ESM.xlsx-Curated_GSEA_gene_sets-TAL1_SANDA_ET_AL_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226408_1_v_0_inpp4b_human	RummaGEO Gene Perturbation Signatures	1.0	null
disease of cellular proliferation	GWASdb SNP-Disease Associations	1.0	0.168677
GSE195582_0_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OVCAR5	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34371
PC14	CCLE Cell Line Gene CNV Profiles	1.0	1.35076
FLI1_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Irinotecan_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0193983
PMC10243915-uxad037_suppl_supplementary_table_s1a.pdf-551-HBP1_HBP1	Rummagene Transcription Factor Associations 2026	1.0	null
SAP30	ENCODE Transcription Factor Targets	1.0	null
K562_SB431542_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167553
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3029394-pone.0016617.s001.xls-Down-regulated-Table_S1_Genes_down-regulated_by_SOX2_over-expression_0_5-fold_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
lymphoma	GWASdb SNP-Disease Associations	1.0	0.283804
496100533_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.16826
Retinoic acid_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0174711
PMC11046918-12967_2024_5211_MOESM4_ESM.xlsx-F_HT1080_FUS-DDIT3_regulated-Table_S2_Regulated_genes_between_scaffold-cultured_and_monolayer-cultured_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.92124
GSE235066_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_TGX-221_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198515
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4699-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cochlear nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.2971
Axonemal central apparatus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.182
GTEX-QDT8-0926-SM-32PL2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24729
testis_7b	HPA Tissue Sample Gene Expression Profiles	1.0	0.961274
SIN3A	ENCODE Transcription Factor Targets	1.0	null
bone	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.989742
GSTZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22583
GSE168807_0_v_7_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lateral part of cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.757
Lung squamous cell carcinoma_LUSC_TCGA-85-6561-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-524-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
GSE145476_2_v_0_hopx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RM2N-1926-SM-48FCU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28786
GSE193258,GSE193259_2_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
17495134-TableS1	GeneSigDB Published Gene Signatures	1.0	null
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12711
Perturb_17279_KO_Mlx_SRP303876	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.00768
A549_BRD4770_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174732
GTEX-X8HC-1626-SM-46MWE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32227
GSE258991_5_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lymph_Node-regulatory t cell	Tabula Sapiens Gene-Cell Associations	1.0	0.400189
GSE158456_1_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Blood Pressure	dbGAP Gene-Trait Associations	1.0	0.099562
CiliaryGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.54475
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Meprednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156149
PMC3500769-srep00875-s3.xls-AP1-Time_4_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
Immune system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.006
PMC12178829-mmc4.xlsx-Sheet_3-MEG3-KD_Down-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WXYG-2326-SM-4E3I6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921915
PMC3500769-srep00875-s3.xls-PAX2-Time_4_PAX2	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8204-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.51744
GSE89018_1_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
MCF7_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0262748
AM 630	DeepCoverMOA Drug Mechanisms of Action	1.0	0.42
GSE160083,GSE160084_2_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE123689_1_v_0_cbx8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04416
abnormal internal genitalia	GWASdb SNP-Phenotype Associations	1.0	0.157934
A549_Ruxolitinib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140043
Sarcoma_SARC_TCGA-X6-A8C3-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-6882-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r3 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11665
NCI-H226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.973773
periventricular stratum of m2AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.85285
intracellular organelle part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Lung squamous cell carcinoma_LUSC_TCGA-18-5595-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07627
CLASP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16966
midbrain raphe nuclei	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.01575
TCFCP2L1-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WOFL-0726-SM-3MJG4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10786
GSE202744_1_v_3_toyocamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
tonsil	HPA Tissue Gene Expression Profiles	1.0	1.69533
GSE180200,GSE180201_5_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_ENMD-2076 L-Tartaric acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136894
Brain Lower Grade Glioma_LGG_TCGA-WY-A85A-01A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-D_eGFP_vs_WT-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
medial parabrachial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.990779
Brimonidine_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0271317
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20597
MYCN-28898695-NB1643-HUMAN-NERVE-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A7WH-01A-22R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48117
PMC8065135-41467_2021_22068_MOESM6_ESM.xlsx-F_MYOG_bindning_in_upregulated-Unnamed_1_MYOG	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.35201
Trifluridine_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0249609
Heart Diseases	CTD Gene-Disease Associations	1.0	1.03976
medial tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48934
retina	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.857208
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-P4PP-0008-SM-48TDV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.975741
Sodium Salicylate_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0193216
K562_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153262
Basal body patch	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.097
WHSC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lymphoid tissue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE182680,GSE182683_5_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OOBK-2126-SM-3LK5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97398
NCI-N87	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151528
GSE182680,GSE182683_5_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.49379
MCF7_Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131332
A549_AC480_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021875
all	GWASdb SNP-Phenotype Associations	1.0	0.096362
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.31077
spindle pole	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
A549_AT9283_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00997586
liver	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.910029
abnormality of thyroid physiology	GWASdb SNP-Phenotype Associations	1.0	0.77446
GSE140092_0_v_1_socs3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE88819_1_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner SZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02575
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7440-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_2746_KD_MYC_SRP358852	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-WFON-2126-SM-3LK7O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18385
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.845051
MCF7_Entacapone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180361
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
K562_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186322
K562_TMP195_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151295
MCF7_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212085
STAT3	ENCODE Transcription Factor Targets	1.0	null
GSE205730,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GABPA_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PSDG-0226-SM-33HC1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26719
GSE223008_7_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE162892_4_v_5_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_WP1066_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181727
Ciliary vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.198
NCI-H2342	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WYVS-2326-SM-3NMAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879503
lateral reticular nucleus (principal part)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.69047
A549_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215951
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPIC-0226-SM-3GADO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915773
Foxj3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	58.1567
cell part	GO Cellular Component Annotations 2015	1.0	null
GSE182680,GSE182683_5_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
microtubule organizing center part	GO Cellular Component Annotations 2015	1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.225
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZG-0326-SM-47JXN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942281
GSE161846,GSE161849_1_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
P70S6K	Kinase Library Serine Threonine Kinome Atlas	1.0	null
CERS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30737
Neoplasms	CTD Gene-Disease Associations	1.0	1.30329
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE218060_7_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	1.0	1.0781
GSE112860_3_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.415
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.91951
Graves Disease	DisGeNET Gene-Disease Associations	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.873239
Centrosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.239
Cytoplasmic microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.46
GSE82104,GSE82299_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Pracinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0101354
GTEX-RWSA-0826-SM-2XCBF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05626
A549_GSK J1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173149
posteroventral (inferior) parietal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12985
trochlear nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.858283
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.42812
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	52.2
Hand1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.9322
MCF7_AZ 960_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177438
Lymphoblast	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCF7_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172344
Intraciliary transport particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.229
Aliskiren_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0148839
GSE152379_0_v_4_bach2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135350_2_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Minodronic acid_SW480	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0205149
A549_WP1066_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176797
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2083_KD_Pan3_SRP087494	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Primary somatosensory area, barrel field, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28274
A549_IOX2_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159958
abnormalities of the peripheral arteries	GWASdb SNP-Phenotype Associations	1.0	0.256548
hsa-miR-520e	TargetScan Predicted Conserved microRNA Targets	1.0	0.404082
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828818
GSE118766_1_v_0_ifng_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210911_1_v_0_crem_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
Hypothyroidism	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.052
A549_Valproic acid sodium salt_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200325
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.28569
H2803	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC3500769-srep00875-s3.xls-CEBP-Time_0_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XV7Q-0126-SM-4BRVK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00951
Idarubicin (hydrochloride)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0253266
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61607
alzheimer's disease	GWASdb SNP-Disease Associations	1.0	0.497098
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15798
Perturb_6228_KO_Mbnl1/Mbnl2_SRP142522	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.69294
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_Linifanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0409996
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.72983
K562_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192309
GSE89767_6_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-V1D1-2126-SM-4JBH4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83187
HCC2218	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.847452
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A1OB-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver Diseases	CTD Gene-Disease Associations	1.0	1.07625
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.112
Inner medullary collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.914
A549_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161877
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE178714_3_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.097834
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.00472
caudal subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.888066
K562_Alisertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171789
BATF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.878762
GSE103068_5_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3052
K562_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165525
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTF3C3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23378
GTEX-WYVS-0326-SM-3NM9V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24562
GSE200673,GSE200691_1_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lingula (I), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42923
SW948	DepMap CRISPR Gene Dependency	1.0	3.04961
MCF7_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0241597
layer V of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.863649
rheumatoid arthritis	GWASdb SNP-Phenotype Associations	1.0	1.04365
GSE142684_3_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-4486	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Spindle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE246195,GSE246305_1_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.38386
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HEP G2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00445
K562_PF-573228_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157512
chr14_80555985_T_C_b38	GTEx eQTL 2025	1.0	1.33087
GTEX-SNOS-0926-SM-4DM7A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.914114
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.20476
GTEX-XOTO-0526-SM-4B662	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07948
Busulfan_SW480	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.01815
PMC8528285-pbio.3001085.s010.xlsx-Fig_7G-MAX_KO_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
Irinotecan_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0275633
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HNF4A	ChEA Transcription Factor Targets	1.0	null
Graves' disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.365
Autoimmune disease of endocrine system	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.006
motor nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20064
NOB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9819
HCT-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
abnormality of lipid metabolism	GWASdb SNP-Phenotype Associations	1.0	0.686325
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5706-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE89018_6_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
bone inflammation disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.256228
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A5ST-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE244072_4_v_0_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE223008_6_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute promyelocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.602
A549_MLN8054_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129471
GSE192663_3_v_2_acly_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_FLLL32_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147831
HDAC1	ENCODE Transcription Factor Targets	1.0	null
GSE118077_7_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Arx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.8209
A4FUK	CCLE Cell Line Gene Expression Profiles	1.0	1.53483
GSE231641_0_v_1_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203308_14_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lingula (I), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24317
Lung adenocarcinoma_LUAD_TCGA-38-4630-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Daptomycin_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0146912
A549_MK-0752_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0217898
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
thoracic cancer	GWASdb SNP-Disease Associations	1.0	0.442605
GSE175787_5_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66717
Bardet-Biedl syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.359
K562_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0114574
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02633
periventricular stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48638
RRP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86859
GSE140651,GSE140653_3_v_7_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Centriolar satellite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.927
Lung adenocarcinoma_LUAD_TCGA-78-7159-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE165682_0_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PcPV part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.99987
GSE195568_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE229973_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4944136-srep28995-s2.xls-DUXA-gene_DUXA	Rummagene Transcription Factor Associations 2026	1.0	null
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16
uterine cancer	GWASdb SNP-Disease Associations	1.0	0.442605
Skeletal Muscle Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.08791
MCF7_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153359
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NKX6-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7464
Centrosomal protein of 128kDa	InterPro Predicted Protein Domain Annotations	1.0	null
A549_Linifanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241959
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_3_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
orbital frontal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.53123
SK-PN-DW	COSMIC Cell Line Gene Mutation Profiles	1.0	null
WHSC1	ENCODE Transcription Factor Targets	1.0	null
K562_Droxinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015641
STK832240	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BL2700 (STK24)	NURSA Protein Complexes	1.0	null
Perturb_3145_KO_Mrfta/Mrtfb_SRP388810	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.81787
GSE89018_1_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
m2 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31286
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Plasma membrane bounded cell projection	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
C20orf96	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19108
GSE229973_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
L-Thyroxine (sodium salt pentahydrate)_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.012648
hsa-miR-20a	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
A549_Barasertib_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0203706
SKN	DepMap CRISPR Gene Dependency	1.0	5.11648
GTEX-T2YK-0008-SM-4DM6M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839029
MOLP8	CCLE Cell Line Gene Expression Profiles	1.0	3.40795
Tracheal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.875
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.35571
cytoskeletal part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE223008_11_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Amsacrine_SW480	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0271901
GSE193177_1_v_3_st266_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Trifluridine_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0305074
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5559-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary motor area, Layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12733
hsa-miR-1285	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
CA SKI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35528
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7897-01A-21R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_ENMD-2076_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019052
GSE145445,GSE145454_0_v_1_cop1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nucleus ambiguus, dorsal division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11255
Sperm head-tail coupling apparatus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.634
A549_AT9283_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216449
VAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5205
MCF7_TAK-901_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128562
GTEX-U8T8-1426-SM-3DB9H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44898
VIIAf	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.861676
HCC2935	CCLE Cell Line Gene CNV Profiles	1.0	1.40861
tauopathy	GWASdb SNP-Disease Associations	1.0	0.497098
NCI-SNU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
r9 part of the lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40358
A549_Cediranib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0295786
lateral ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.37847
Perturb_4177_KO_Dnmt1_SRP043000	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.25127
K562_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016124
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.0035
GTEX-UPIC-0726-SM-3GADW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.964834
GSE158834_12_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223008_5_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE191105_2_v_4_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_BRD4770_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169342
JL1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3899
GSE65617_2_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8C_Het1A-HNF4A_2d_5x_closed-Nearest_Ensembl_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OXRO-0011-R10A-SM-2I5EH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862853
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.051489
C32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE229973_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25652
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.32494
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
FLI1	ENCODE Transcription Factor Targets	1.0	null
hemolytic anemia	GWASdb SNP-Disease Associations	1.0	0.875106
Ciliary necklace	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.539
hsa-miR-134	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
H3K36me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.982862
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.908564
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.623
MCF7_Luminespib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0085633
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.12634
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDVJ-0005-SM-2TC5X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830276
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.302
COV644	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64696
GTEX-OOBJ-2026-SM-3NB1R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86561
Lung squamous cell carcinoma_LUSC_TCGA-22-1005-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EL-01A-12R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
(Z)-Pugnac	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
K562_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178977
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE231720,GSE231724_2_v_0_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
male infertility	MGI Mouse Phenotype Associations 2023	1.0	null
Perturb_2055_KD_NR2F2_ERP124128	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
A549_Roxadustat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183859
GTEX-REY6-0126-SM-48FDT	GTEx Tissue Sample Gene Expression Profiles	1.0	2.28924
ZNF384_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Tazemetostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181259
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
hsa-miR-4676-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Perturb_11705_KD_HOXA1_SRP012607	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Primary somatosensory area, trunk, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51071
FURIN_Deficiency_GDS3512_568_mouse_T-cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
NH12	DepMap CRISPR Gene Dependency	1.0	3.32474
hsa-miR-216a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
K562_Regorafenib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209154
GSE236497,GSE236500_1_v_0_pemrametostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
STRN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87622
intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
abnormality of the kidney	GWASdb SNP-Phenotype Associations	1.0	0.130531
A549_PFI-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0242653
NB10	DepMap CRISPR Gene Dependency	1.0	3.6176
GSE196699_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_5_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Danusertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179953
Brain Lower Grade Glioma_LGG_TCGA-DB-5277-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2914-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lymphnode_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.55429
RKO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-L1-A7W4-01A-12R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CA2 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15952
GSE211286_7_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Darolutamide_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.013162
PMC11285331-cd-23-0539_table_s1_suppst1.xlsx-Lost_AR_Peaks-Unnamed_20_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
renal neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.379543
GSE220600_1_v_2_clpp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SHP-77	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-TSE9-0126-SM-3DB83	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955717
TGBC11TKB	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Salivary_Gland-plasma cell	Tabula Sapiens Gene-Cell Associations	1.0	0.461169
Crus 1, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2525
CSTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74554
SOX2-20726797-SW620-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
substantianigra	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.904667
Piroxicam_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0100675
MCF7_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0272347
HCT-116	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.920293
A549_PCI-34051_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183666
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HERC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77261
coronary artery disease	GWASdb SNP-Phenotype Associations	1.0	0.795881
SK-N-FI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.875991
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
P70S6KB	Kinase Library Serine Threonine Kinome Atlas	1.0	null
GSE154961,GSE154963_4_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Daptomycin_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0140222
IGF1R_druginhibition_46_GSE14024	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.16303
urinary system cancer	GWASdb SNP-Disease Associations	1.0	0.324948
A549_Dacinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125966
MCF7_Quercetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0220808
principal sensory nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13237
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13833
Bed nuclei of the stria terminalis, anterior division, anterolateral area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33156
GTEX-PWOO-2326-SM-2S1PQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11972
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.236
Hematopoietic cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_AC480_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015637
intracellular part	GO Cellular Component Annotations 2015	1.0	null
MCF7_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160069
REST	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-520d-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	1.33645
lower respiratory tract disease	GWASdb SNP-Disease Associations	1.0	0.204498
efo21	HPA Cell Line Gene Expression Profiles	-1.0	-1.42376
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.3
MCF7_Regorafenib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014358
MCF7_Hesperadin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146355
GSE87617_1_v_0_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.31488
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Differentially_expressed_genes_identified_in_bulk_RNA-seq_of_FOXO1-_-_vs_FOXO1_hMSCs_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Regorafenib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241146
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.19855
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7219
Brain Lower Grade Glioma_LGG_TCGA-DU-6407-02B-11R-A36H-07,TCGA-DU-6407-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventral tuberomammillary nucleus, superficial part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23455
Neurodegenerative Diseases	CTD Gene-Disease Associations	1.0	1.13655
Spindle pole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.452
hsa-miR-3942-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
A549_Regorafenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0270434
GSE131377_1_v_3_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Ki8751_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01969
A549_BMS-754807_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0219984
DCUN1D4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10563
nuclear membrane	GO Cellular Component Annotations 2025	1.0	null
MKRN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16378
GTEX-XOT4-0326-SM-4B66S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02649
Acrosomal vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.291
GSE139455_0_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2712-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0211358
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0251038
GTEX-U3ZM-1626-SM-4DXSK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.985275
r10 part of the vestibular column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.67701
r8 part of linear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38496
DNAJC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05668
Hmga1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.9347
PMC12224929-ADVS-12-2416784-s006.xlsx-DEG_circGLIS3_KD-Unnamed_6_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Droxinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197325
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.23679
VZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.910431
hsa-miR-4643	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
MCF7_Tucidinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00822126
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25929
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.990942
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1QA-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE229671,GSE229673_2_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140823
A549_Hesperadin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0227911
GSE148066,GSE157787_5_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormality of skeletal morphology	GWASdb SNP-Phenotype Associations	1.0	0.078392
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.65511
Alx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.9706
MCF7_Barasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155423
A549_SRT2104_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210291
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XGQ4-0326-SM-4GIEE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18434
vincristine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0137171
HCV_8week-No IFN-a_None_GSE37715	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.81193
GTEX-SNMC-1026-SM-4DM7K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35177
Lung squamous cell carcinoma_LUSC_TCGA-77-8139-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE153189_1_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.916916
GTEX-QEL4-0726-SM-3GIJ5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.76046
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27054
GSE171177,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Curcumin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166385
anemia	GWASdb SNP-Disease Associations	1.0	0.399029
SNU-638	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.82696
GTEX-X4EO-0526-SM-3P5Z3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838215
diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.299011
GSE95077_1_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
TE-10	COSMIC Cell Line Gene CNV Profiles	1.0	2.10038
SOX17-20123909-XEN-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_4554_KD_Mcrs1_SRP126769	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.98363
pineal_day	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.932787
GTEX-QMR6-1326-SM-32PLB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857059
Perturb_17652_KD_DNMT3A_SRP367237	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.72909
CD34+	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.33883
PMC4219345-1471-2121-14-52-S4.xlsx-BORIS_6dN-Gene_Symbol_CTCFL	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal respiratory system morphology	GWASdb SNP-Phenotype Associations	1.0	0.226684
Kidney Chromophobe_KICH_TCGA-KN-8422-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Tomivosertib_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00913423
A549_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.027836
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3500769-srep00875-s3.xls-CEBP-Time_24_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
cuneiform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15214
GP5D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17816
intracellular non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Acute Myeloid Leukemia_LAML_TCGA-AB-2971-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
non-small cell lung carcinoma	GWASdb SNP-Disease Associations	1.0	0.698242
SZ in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09067
A549_ITSA-1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198969
Ciliary transition fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.414
A549_Crizotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135825
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100376_FWM_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.26185
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35509
Mitoxantrone (dihydrochloride)_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0231817
HOXB13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12478
PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
hairpin sperm flagellum	MGI Mouse Phenotype Associations 2023	1.0	null
Orofaciodigital syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
RUNX2	ChEA Transcription Factor Targets	1.0	null
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR	Rummagene Transcription Factor Associations 2026	1.0	null
superficial stratum of r3Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02819
GTEX-PVOW-1026-SM-2XCF9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909697
Bardet-Biedl syndrome 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
DAUDI	CCLE Cell Line Gene Expression Profiles	1.0	1.75144
RBBP5	ENCODE Transcription Factor Targets	1.0	null
GSE171175,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Neoplasm Metastasis	CTD Gene-Disease Associations	1.0	1.07093
GTEX-V1D1-2026-SM-3GAF4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21478
GTEX-WYBS-0926-SM-3NM94	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87747
A549_SNS-314 Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0278442
carbamoyl-phosphate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.86
PROP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.7104
P3H3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39867
CA3 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.49837
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5754
Centriolar subdistal appendage	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.771
A549_Ki8751_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205777
Asciminib_NCI-H23	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0215052
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13962
RSV-A2_24Hour-KO_RSV_None_GSE18170	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.76887
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.86504
Perturb_253_KD_USP18_SRP364866	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
LHX1_NULL MUTATION - Ablation_GDS1748_749_mouse_Embryonic kidneys (from day E18.5)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-X8HC-0526-SM-4E3JA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11057
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
GSE123861_1_v_0_sin3a_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE173232_1_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210101,GSE210114_8_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
SOX17	ChEA Transcription Factor Targets	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A820-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58401
GTEX-REY6-0726-SM-2TF4M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13936
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SKM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41586
HOXC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4881
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.28366
GSE199899_4_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.29884
hsa-miR-1269	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GTEx Uterus 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	3.92394
abnormality of the thyroid gland	GWASdb SNP-Phenotype Associations	1.0	0.3494
liver_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.826832
GSE213588_8_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lumateperone (tosylate)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0251005
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08767
H3K79me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
STX-0119	DeepCoverMOA Drug Mechanisms of Action	1.0	0.55
A549_MLN8054_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178718
Ovary	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.25607
mantle zone of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19952
PMC8554124-DataSheet2.XLSX-34-RFX3_RFX3	Rummagene Transcription Factor Associations 2026	1.0	null
CEBPA-23403033-LIVER-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE123825_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE184892_7_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
superficial stratum of cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32926
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-302e	TargetScan Predicted Conserved microRNA Targets	1.0	0.283838
MCF7_Hesperadin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0214963
Pimitespib_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00491858
PMC11384724-mmc4.pdf-45-BCL11A_BCL11A	Rummagene Transcription Factor Associations 2026	1.0	null
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.31897
GSE183113_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Tucidinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0228147
NFIL3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8718
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Ezatiostat	DeepCoverMOA Drug Mechanisms of Action	1.0	0.19
GSE231648_4_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00356
neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.182333
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20049
MCF7_Raltitrexed_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0232624
MCC13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC9170563-12885_2022_9665_MOESM3_ESM.docx-0-Candidata_target_genes_of_CEBPB_3_CEBPB	Rummagene Transcription Factor Associations 2026	1.0	null
Supraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.29873
PMC12068594-pgen.1011693.s007.xlsx-MCR_vs_MCB-gene_id_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HW-8319-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10169359-13058_2023_1653_MOESM1_ESM.xlsx-Table_S9-Table_S9_Genes_differentially_expressed_between_TP53_mutant_and_wild-type_pBCs_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6405523__F4	PFOCR Pathway Figure Associations 2023	1.0	null
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
inner SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26387
hsa-miR-302c	TargetScan Predicted Conserved microRNA Targets	1.0	0.283838
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WM793_SKIN	CCLE Cell Line Proteomics	1.0	2.21913
Tofacitinib_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0136456
Ciliary tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.925
Ciliary shaft	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.508
ZNF597	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8331
cytoskeleton	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MG-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.31362
PMC12522211-NIHMS2104691-supplement-MMC1.xlsx-SRCAP_DE_genes-Gene_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.09822
Fascia adherens	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.518
ELK1	ENCODE Transcription Factor Targets	1.0	null
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03258
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00065
GSE162892_3_v_1_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Paclitaxel_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0235435
Phenylephrine (hydrochloride)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0130377
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CEBPA-23403033-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30565
MCF7_Busulfan_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0242082
GSE82032_3_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormal sperm axoneme morphology	MGI Mouse Phenotype Associations 2023	1.0	null
GSE223008_6_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226397_0_v_1_cystine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HOP-92	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.74329
RAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.4832
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02108
hsa-miR-4425	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
SARS-BatSRBD_60Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.20677
GSE122509,GSE122513_3_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.963192
hsa-miR-3128	TargetScan Predicted Conserved microRNA Targets	1.0	0.241055
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-302a	TargetScan Predicted Conserved microRNA Targets	1.0	0.336728
GSE143847_2_v_3_inhba_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Gene_Name_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
A253	CCLE Cell Line Gene CNV Profiles	1.0	1.79572
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.006
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6478-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hematological neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.168805
GTEX-VJYA-1426-SM-4KL1Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1381
PMC11073998-41375_2024_2235_MOESM9_ESM.xlsx-THP1_phosphoproteome-Unnamed_2_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
bone inflammation disease	GWASdb SNP-Disease Associations	1.0	0.320318
PMC10709142-41556_2023_1281_MOESM2_ESM.xlsx-Supplementary_Table_1-CLUSTER_2_MAF_downregulated_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
Urinary bladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.457
Phenytoin (sodium)_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0279273
GTEX-RTLS-0926-SM-2TF5X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892187
ZNF382	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.1841
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE249098_3_v_0_mthfd1l_human	RummaGEO Gene Perturbation Signatures	1.0	null
A-317491	DeepCoverMOA Drug Mechanisms of Action	1.0	0.93
GSE216147_2_v_1_rbm20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SOX15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55222
GTEX-QLQW-0326-SM-447A8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08175
GSE115542_2_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MDAMB436	CCLE Cell Line Gene CNV Profiles	-1.0	-2.76363
GTEX-RM2N-0326-SM-48FD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46804
GTEX-QVUS-2926-SM-3GIJB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04531
K562_Lenalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0305138
GSE88819_5_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_ENMD-2076_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158682
A549_Decitabine_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146113
COLO-792	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13962
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-7699-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_SBP_AA-SYMBOL_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5KZ-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE218060_2_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.906535
GSE220806_0_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226249_5_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KMS27	CCLE Cell Line Gene Expression Profiles	1.0	2.25751
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5QE-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_CYC116_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153468
GSE143643,GSE143644_4_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_TMP195_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0329504
769-P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.63408
GSE134896_0_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Bisindolylmaleimide IX_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240887
SRF	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IH-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pallidal part of olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18794
Perturb_9823_KD_TAL1_SRP103740	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.11335
inferolateral temporal cortex (area TEv, area 20)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.999827
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6467-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Panobinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0059231
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4900-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6889
GTEX-RM2N-1326-SM-48FCW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75814
COLO677	CCLE Cell Line Gene Expression Profiles	1.0	1.80744
A549_Pracinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0121455
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1413
PMC2813300-pone.0008960.s011.xls-SOX2_squamous_signature-Gene_Symbol_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
immune system cancer	GWASdb SNP-Disease Associations	1.0	0.11773
MOLP-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	3.19968
GSE88819_6_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206984_1_v_0_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
posterior hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.948723
mantle zone of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18661
OUMS-23	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0220939
A-Netherlands-602-2009(H1N1)_24Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.55823
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.966815
PMC6811834-sby183_suppl_supplementary_data_set_1.xls-ZNF804A_DEX_FDR_0_01-Gene_Symbol_ZNF804A	Rummagene Transcription Factor Associations 2026	1.0	null
intermediate stratum of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.82458
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11526
GSE110268_2_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Endocrine system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.006
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-mouse_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
A549_MC1568_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131155
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08622
RS4-11	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Resveratrol_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0285085
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.950134
ventrolateral prefrontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03061
NCI-H82	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19509
GSE81803,GSE81912_2_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208253
YARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46751
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.171
OCI-M2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.868816
GSE171177,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.961278
GSE168401_1_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NRF2-31884422-A549-HUMAN-LUNG-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
PMC10985171-Table_1.xlsx-Table_S3-Table_S3_IPF_related_genes_screened_by_MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Nuclear envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
MCF7_Obatoclax Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186552
K562_Roxadustat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017047
Folic acid_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0261493
Nfe2l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.3333
Adrenocortical carcinoma_ACC_TCGA-OR-A5KO-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15600_KO_Twnk_SRP319510	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.38194
organism form	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12397
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Belinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127499
DCLRE1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04862
MCF7_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152521
A549_Hesperadin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182115
A549_Alvespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175434
Docetaxel_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.015186
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6482-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EVX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9843
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.58389
GSE149880_2_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134358
MCF7_AZD1480_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148232
TIMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08511
Insulin Resistance	CTD Gene-Disease Associations	1.0	1.03493
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nephronophthisis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.019
Brain Lower Grade Glioma_LGG_TCGA-DU-7301-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE112860_5_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE179974_3_v_1_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE188458_2_v_0_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
STAT1::STAT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.1548
A549_Luminespib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0229064
GTEX-SIU8-0626-SM-2XCDN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31666
GBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6972
protein localization	GO Biological Process Annotations 2025	1.0	null
A549_Fluorouracil_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.011009
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Salicylic acid_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.029401
Spi1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.7505
A1CF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35164
testis_7e	HPA Tissue Sample Gene Expression Profiles	1.0	0.930681
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ADCY6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52906
A549_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0307988
CMLT1	CCLE Cell Line Gene Expression Profiles	1.0	1.62289
GSE231745_1_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19434
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5363-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_Enzastaurin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0309468
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.877222
GSE210580_0_v_2_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14658
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917906
K562_TMP195_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151071
Perturb_2177_KD_DDX24_SRP339923	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.75153
SLC25A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17601
GTEX-WWYW-0826-SM-3NB2X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05767
arterial stenosis	GWASdb SNP-Phenotype Associations	1.0	0.256548
RVH-421	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-PSDG-0008-SM-48TE5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45005
A549_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0456575
H2BC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01641
embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RD	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03143
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.2068
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.22
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE130217_0_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PANC 05.04	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.855775
Uterine Carcinosarcoma_UCS_TCGA-NA-A4QY-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.163
GSE168458_1_v_3_disulfiram_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lateral cell cortex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.887
orbital frontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.892814
KYSE30	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46702
carbohydrate metabolism disease	GWASdb SNP-Disease Associations	1.0	0.25668
Brain Lower Grade Glioma_LGG_TCGA-DH-A669-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_TAK-901_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186359
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.31375
HOXB4	ChEA Transcription Factor Targets	1.0	null
Non-alcoholic Fatty Liver Disease	CTD Gene-Disease Associations	1.0	1.01549
PMC11781671-ppat.1012897.s015.xlsx-Tab_S1-S1_Table_The_detailed_information_of_DEGs_in_Huh7_cells_post_MSX1_overexpression_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1937_BREAST	CCLE Cell Line Proteomics	1.0	2.39778
Lung adenocarcinoma_LUAD_TCGA-50-6590-01A-12R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_INO-1001_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140068
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-10a-5p	MiRTarBase microRNA Targets	1.0	null
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216185
GTEX-VUSG-1726-SM-4KKZL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23795
GSE218060_5_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-69-7761-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE89018_11_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Paramedian lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.02636
A549_UNC1999_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136324
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWOO-0826-SM-48TCL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.24873
vascular disease	GWASdb SNP-Disease Associations	1.0	0.15504
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.26489
outer SZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02771
GTEX-U4B1-0626-SM-3DB8L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07126
A549_Pelitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0228868
MCF7_Regorafenib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137709
MCF7_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149178
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63597
TJAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23793
diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.273541
ESR1-22446102-UTERI-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Prelimbic area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06671
Pemigatinib_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0379796
A549_ENMD-2076_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131094
Procentriole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.892
MCF7_Decitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189251
A549_SRT2104_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013284
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39139
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.31602
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Alisertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198832
Brain Lower Grade Glioma_LGG_TCGA-CS-4943-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.92006
Capivasertib_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0251353
A549_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222904
A549_PJ34_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152785
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
C32	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HSF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.4618
A549_Linifanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147921
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.84651
GSE226249_0_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
periventricular stratum of JcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.77897
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_Valproic acid sodium salt_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0246511
PMC7946393__F1	PFOCR Pathway Figure Associations 2023	1.0	null
Ciliary plasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.874
CNNM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04394
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.905482
MCF7_JNJ-26854165_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0244764
Lung adenocarcinoma_LUAD_TCGA-55-8092-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132425
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
Hypertrophy	CTD Gene-Disease Associations	1.0	1.13621
K562_Nintedanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0204888
r6 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13972
Microtubule organizing center	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.335
K562_Entacapone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194038
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
A549_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216518
SW 48	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.926987
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019434
PMC3500769-srep00875-s3.xls-GATA3-Time_1_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
TE10	CCLE Cell Line Gene CNV Profiles	1.0	2.22559
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.381
hsa-miR-106b	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05006
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BICR56	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54094
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal hemoglobin	GWASdb SNP-Phenotype Associations	1.0	0.768197
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Zbtb2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.6771
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.36704
PMC10534007-Table_2.xlsx-S4_unique_down_MSC_V-745_elements_included_exclusively_in_VM-CUB1_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146945
MCF7_Fulvestrant_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0116243
Blood	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Prospore contractile ring	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.535
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
RERF-LC-KJ	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TEAD4	ChEA Transcription Factor Targets	1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.22207
abnormality of head or neck	GWASdb SNP-Phenotype Associations	1.0	0.082771
hsa-miR-670	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
abnormality of blood and blood-forming tissues	GWASdb SNP-Phenotype Associations	1.0	0.132873
Pancreatic_Islets	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.225
CK1G3	Kinase Library Serine Threonine Kinome Atlas	1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-N7MS-0008-SM-4E3JI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832352
ECD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17313
MCF7_MK-0752_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178078
GSE119978,GSE180930_6_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IJ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Memory Disorders	CTD Gene-Disease Associations	1.0	1.23616
MCF7_Navitoclax_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014661
GSE94011_0_v_3_pias3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UMRC2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58877
A549_Roxadustat_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169986
A549_Pirarubicin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190101
GSE119978,GSE180930_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHLA57	DepMap CRISPR Gene Dependency	1.0	2.76472
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Axonemal central pair	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.196
GSE113106_2_v_5_dnm2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SA-A6C2-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.45
Sperm head	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.066
Palmatine (chloride)_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0285942
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YD-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MC-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Methotrexate_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0149734
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.88062
PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R55G-2326-SM-2TC61	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899832
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PLK1_druginhibition_181_GSE46856	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.63961
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.50964
GSE147876,GSE147877_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PECAPJ34CLONEC12	CCLE Cell Line Gene CNV Profiles	1.0	1.50622
CLDN11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05725
Vemurafenib_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0352312
GSE152441,GSE152442_6_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
horizontal nucleus of the diagonal band	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.95681
SPI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.44029
GSE233679_5_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gfi1b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.958
CELSR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39727
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE182680,GSE182683_0_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RU72-0726-SM-46MUW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19583
Prostate adenocarcinoma_PRAD_TCGA-J4-8198-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Mocetinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015757
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hippocampus (hippocampal formation)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.34518
GSE89018_11_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lateral parabrachial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02896
GTEX-WFON-2026-SM-4LVMW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05777
STAT5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24744
A549_Bosutinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0269832
GSE203308_15_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Panobinostat_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.015854
A549_Pracinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138857
pineal_night	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.893099
GSE173810_4_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.22325
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
K562_Nintedanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171355
A549_Celecoxib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241302
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28618
Pitavastatin (Calcium)_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0194647
abnormal genital system morphology	GWASdb SNP-Phenotype Associations	1.0	0.111985
GSE221577_2_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Skin - Sun Exposed (Lower leg)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.670688
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93304
orbital frontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02511
Pharynx cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.135
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.75662
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922309
MRK-NU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hemoglobins	GAD Gene-Disease Associations	1.0	null
MCF7_Bosutinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167292
SPI1	ENCODE Transcription Factor Targets	1.0	null
spleen	HPA Tissue Protein Expression Profiles	-1.0	-0.819063
Axoneme	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.874
hsa-miR-20b	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
A549_PFI-1_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01513
mantle zone of CbH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18406
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12571111-qiaf131_supplementary_data.xlsx-ST2-Supplementary_Table_2_Results_of_the_two-sample_MR_analysis_on_the_causal_role_of_CD4_T_cell_expression_profiles_on_CRC_development_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE89018_6_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Olfactory tubercle	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02098
DorsalRootGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.1038
Lucanthone_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0264621
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.23665
NCIH1755	CCLE Cell Line Gene CNV Profiles	-1.0	-2.72681
lateral intermediate part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.824707
MCF7_Resminostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140793
OXNAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31031
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
JURKAT, CLONE E6-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17089
Brain Lower Grade Glioma_LGG_TCGA-HT-7485-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DTX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62883
A549_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0374394
A549_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0294031
corticoid layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06356
superficial stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53064
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ccnd1_18413728_imr_neuroblastoma_lof_human_gpl570_gse8866	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.737275
lateral habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.51912
mantle zone of m2ADL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70422
18362358-Table7	GeneSigDB Published Gene Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-5C-A9VG-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE228413_2_v_1_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ivermectin_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00750126
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hemoglobinopathy	GWASdb SNP-Disease Associations	1.0	0.875106
GSE229973_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Trametinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0119815
EMC-BAC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
gamma-tubulin large complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.693
SRPK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53225
A549_Maraviroc_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0378566
MCF7_Temsirolimus_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0250699
cytoskeletal part	GO Cellular Component Annotations 2015	1.0	null
GSE226249_0_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Lung adenocarcinoma_LUAD_TCGA-44-A479-01A-31R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE149901_2_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormality of carbohydrate metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.1794
Paclitaxel_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0221697
MCF7_MK-5108_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157342
496100618_PCx_probable Alzheimer's disease_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.26458
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NELFE	ENCODE Transcription Factor Targets	1.0	null
GTEX-RUSQ-0526-SM-2TF72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20767
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YV-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19S-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.13236
GSE199899_4_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
overnutrition	GWASdb SNP-Disease Associations	1.0	0.453514
Lumateperone (tosylate)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.011162
JIYOYE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.940466
Hoxa13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.4156
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A0YN-11A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Medial pretectal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28852
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.52002
GSE145323,GSE145324_1_v_0_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of PHyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15394
tuberomammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.96029
GSE205316,GSE205317_2_v_1_nrip1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.877977
GSE89767_7_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_7261_KD_EP300_SRP193326	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
K562_PD98059_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0229752
SPIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.6187
A549_G007-LK_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0213687
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.75364
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
A549_Obatoclax Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0388424
metabolic	GAD High Level Gene-Disease Associations	1.0	0.293278
m1AD (DM) part of periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35089
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2659
MDA-MB-436	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.38669
Seckel syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.50964
Doxorubicin (hydrochloride)_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0160721
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.16137
GSE103068_0_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Asphyxiating thoracic dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.328
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
nucleus	LOCATE Predicted Protein Localization Annotations	1.0	null
ETV2::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.458
PMC11285331-cd-23-0539_table_s1_suppst1.xlsx-Lost_AR_Peaks-Unnamed_19_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MEIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7453
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
ChIP_TCFCP2L1_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Oct-2	MotifMap Predicted Transcription Factor Targets	1.0	null
K562_BMS-754807_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147081
hsa-miR-4709-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE58724_1_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22559
GSE86507,GSE86509_7_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SMIM14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35664
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.14885
Brain Lower Grade Glioma_LGG_TCGA-DU-6410-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_ENMD-2076_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144755
MCF7_Carmofur_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.012685
disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.256228
GTEX-N7MT-0126-SM-2D7VT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907132
BL-70	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ventromedial hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.41952
Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-8537-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mammary Neoplasms, Animal	CTD Gene-Disease Associations	1.0	1.19835
Cell projection	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Hypothyroidism	DisGeNET Gene-Disease Associations	1.0	null
GTEX-P4PQ-0326-SM-2HMJ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853181
TCF4	ChEA Transcription Factor Targets	1.0	null
GSE146074_1_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942614
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62406
Nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.202
Estrone sulfate (potassium)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0177446
A549_AG-490_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015525
A549_AZD1480_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206354
A549_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216528
hsa-miR-4795-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
A549_ITSA-1_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159959
nucleus sagulum, superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.7294
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A7U9-06A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Thyroid gland disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.015
Ferulic acid_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0151029
hsa-miR-654-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXO1::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8331
KNS42	DepMap CRISPR Gene Dependency	1.0	2.28658
Sperm connecting piece	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.814
parabigeminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	4.44139
A549_Azacitidine_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142395
MCF7_AZD1480_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154806
Pericentriolar material	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.142
STAT3	ChEA Transcription Factor Targets	1.0	null
abnormality of bone marrow cell morphology	GWASdb SNP-Phenotype Associations	1.0	0.231063
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.049831
gamma-tubulin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.911
neoplasm of the respiratory system	GWASdb SNP-Phenotype Associations	1.0	0.295523
hsa-miR-182	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
K562_Streptozotocin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0259332
K562_Enzastaurin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199104
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-Row_names_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RUSQ-2126-SM-47JXK	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04404
A549_PD98059_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0251895
A549_JNJ-7706621_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0112402
HMGN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41019
GSE114992,GSE114993_1_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A953-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PK-45H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.33661
dorsolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.958943
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2249
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE210682_2_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
palbociclib_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0226407
MC1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01968
hsa-miR-548m	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
A549_2-Methoxyestradiol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0223709
GSE203308_15_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormality of the genitourinary system	GWASdb SNP-Phenotype Associations	1.0	0.10146
Perturb_11393_KD_FOXA1_SRP292689	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
HMGN3	ENCODE Transcription Factor Targets	1.0	null
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.33666
GTEX-PSDG-0726-SM-2I5FN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13312
GSE180200,GSE180201_15_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.61822
lymph node	HPA Tissue Gene Expression Profiles	1.0	1.06388
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201637
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.968108
MCF7_Fasudil_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200328
GTEX-TSE9-2626-SM-4DXV2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872188
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14842
primary motor cortex (area M1, area 4)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.900051
HS255T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.91382
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
hsa-miR-3152-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GSE169713,GSE169715_1_v_2_tert_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WRHU-2826-SM-3MJG8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974786
liver	GTEx Tissue Gene Expression Profiles	-1.0	-1.64992
A549_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133461
K562_Alisertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0252944
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17007
GSE182680,GSE182683_7_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
neuroepithelial neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.295523
A549_Capecitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192271
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
retroparafascicular area of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.977834
A549_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187443
GSE222103_0_v_1_ybx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Barasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0252003
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.22824
MCF7_EED226_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145192
MCF7_Divalproex Sodium_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202662
FMK	DeepCoverMOA Drug Mechanisms of Action	1.0	0.7
Tirofiban	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
monomethylarsonous acid	CTD Gene-Chemical Interactions	1.0	null
MCF7_Meprednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139093
periventricular nucleus, preoptic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-3.41306
Primary T cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.2245
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC6713698-109_2019_1809_MOESM2_ESM.xlsx-AR-PCOS-Gene_List_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119978,GSE180930_2_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Roxadustat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0226164
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RPMI-8402	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Vandetanib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170453
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35441
KMS34	CCLE Cell Line Gene Expression Profiles	1.0	1.59392
AZD-7648_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0179906
HOXD4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6498
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.90896
VZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.21399
GSE112860_5_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
MCF7_Valproic acid sodium salt_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0225826
AGS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.990942
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09652
Mitoxantrone (dihydrochloride)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0254988
mRNA_TCF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-ID_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-N7MT-0726-SM-3TW8S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93669
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.62667
MCF7_Epothilone A_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133314
Palmatine (chloride)_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0282364
(R)-Verapamil (hydrochloride)_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0306631
BL5529 (CCDC99)	NURSA Protein Complexes	1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RM2N-1426-SM-2TF4H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896835
Palmitoleic acid (16:1n-7) plasma levels	GWAS Catalog SNP-Phenotype Associations	1.0	0.165905
CHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00855
PMC10742386-pnas.2311372120.sd05.xlsx-DLX3_ST-Gene_Symbol_DLX3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AH-1526-SM-48TZG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39795
Axonemal dynein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.655
Necrosis	CTD Gene-Disease Associations	1.0	1.40008
LPS6	DepMap CRISPR Gene Dependency	1.0	2.43657
Acute Myeloid Leukemia_LAML_TCGA-AB-2842-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_AZ 960_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156085
hematological	GAD High Level Gene-Disease Associations	1.0	0.295739
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1276
Hypothyroidism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.042
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBK-1026-SM-48TC2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30887
GSE180200,GSE180201_5_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
posteromedial visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43111
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.878427
intracellular non-membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
hsa-miR-4796-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
KMS12BM	CCLE Cell Line Gene Expression Profiles	1.0	2.2493
NCI-H1304	COSMIC Cell Line Gene CNV Profiles	1.0	2.10038
MCF7_Epothilone A_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151232
A549_Abexinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0108665
MDA-MB-415	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE211931_1_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Immune system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_AG-14361_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171176
neuropeptide-S nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00404
GTEX-S32W-0726-SM-2XCBL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881334
GSE89018_11_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LARP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00784
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_AZD1480_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.025317
Panobinostat_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0167713
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.259312
MCF7_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167269
GSE138050,GSE148257_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Autoimmune disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.006
A549_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0230923
GTEX-R3RS-0526-SM-3GADG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15103
female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
4h_cisplatin vs ctrl_mESC (Mouse) [22006019]	SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs	-1.0	null
HLF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8099
A549_Abexinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0103272
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
HCFC1	ENCODE Transcription Factor Targets	1.0	null
Lipoproteins	dbGAP Gene-Trait Associations	1.0	0.152913
liver_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.947453
periventricular stratum of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25882
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE149621_2_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bcl11b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.2325
facial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27677
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the vasculature	GWASdb SNP-Phenotype Associations	1.0	0.176888
A549_Nilotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151368
A549_Veliparib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018351
A549_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0244453
connective tissue disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.00486
GSE135244_0_v_1_trdmt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.7778
A549_Ivosidenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0217266
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_PD173074_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181493
A549_Hesperadin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.021061
endometrial carcinoma	GWASdb SNP-Phenotype Associations	1.0	0.599613
GSE154767_4_v_3_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Bisindolylmaleimide IX_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193932
respiratory system disease	GWASdb SNP-Disease Associations	1.0	0.185661
r10 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12663
mantle zone of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18337
A549_ABT-737_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171069
GTEX-R3RS-0626-SM-48FE1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17985
NFATC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1214
MCF7_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0296671
Perturb_6991_KO_Trx1_SRP190456	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.46027
AKT1	Kinase Library Serine Threonine Kinome Atlas	1.0	null
K562_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156142
PMC7069022-Table_1.xlsx-MYCN_Cor_Microarray_Analysis-GENE_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-215-5p	MiRTarBase microRNA Targets	1.0	null
superficial stratum of Pal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19057
breast cancer	GWASdb SNP-Disease Associations	1.0	0.698242
GTEX-XUYS-0326-SM-47JX2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00325
GSE149760_3_v_1_elof1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_2-Methoxyestradiol_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013599
A549_PFI-1_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139023
Gallic acid (hydrate)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0148013
GSE113329,GSE113335_3_v_4_taf6l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE48812_9_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MKS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.022
NCI-H2291	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845003
non-motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.146
GSE134923_1_v_0_ncor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.08447
ventrolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.8656
GTEX-REY6-1226-SM-48FDR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18548
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19913
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90562
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55157
GTEX-R55C-1926-SM-2TF4K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86695
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_2day-MOI-10^3_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.64951
Bexarotene_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0226611
Primary somatosensory area, lower limb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3678
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.44791
496100507_FWM_dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.96005
GTEX-X4XY-1626-SM-46MVN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853981
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56048
HCC38	CCLE Cell Line Gene CNV Profiles	1.0	1.91439
Perturb_2140_KO_ASCC3_SRP282634	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Anethole trithione_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0248858
GSE147626_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Patupilone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168389
GTEX-XYKS-1826-SM-4E3JV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52087
RPP30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01889
NKX6-1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2394
NALM-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MCF7_Trametinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149071
growth abnormality	GWASdb SNP-Phenotype Associations	1.0	0.2855
NCIH1355_LUNG	CCLE Cell Line Proteomics	1.0	2.96328
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5432-01A-02R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
Retinal pigment epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.6
GTEX-WRHU-0006-SM-3MJF6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896305
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
autoimmune disease of endocrine system	GWASdb SNP-Disease Associations	1.0	1.53792
GSE229468,GSE229471_2_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.892489
Y-shaped link	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.46
Primary motor area, Layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14114
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE153836_14_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Developmental Delay (Disorder)	DisGeNET Gene-Phenotype Associations	1.0	null
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_R_species_not_found_in_common_genes_of_LF_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MT-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01723
GTEX-WOFL-0126-SM-3MJG2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26859
GSE169356_0_v_5_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXB13-26457646-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE111660_2_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OHPM-1026-SM-3LK74	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944484
neoplasm of the genitourinary tract	GWASdb SNP-Phenotype Associations	1.0	0.277032
TUHR4TKB	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39553
A549_Alisertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0248639
GSE227891_2_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Megestrol_NCI-H23	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0212667
A549_ZM 447439_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0260913
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.24892
acetaminophen_homo sapiens_gpl6244_gse27420	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE149621_0_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE110178_4_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Aurora A Inhibitor I_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208943
r8 part of basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0897
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A8AZ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_PJ34_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015072
Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YJ-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.43063
KHSRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1241
PMC8117616-12864_2021_7643_MOESM7_ESM.xlsx-1_CHA_GWAS_SNP_results-Gene_symbol_TCFL5	Rummagene Transcription Factor Associations 2026	1.0	null
PR, GR	MotifMap Predicted Transcription Factor Targets	1.0	null
REST_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteromedial visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.88565
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5323-01A-01R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5030-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OVMANA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21969
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10591
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00282
TPGS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58236
GSE116299_6_v_5_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2697
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4Q7-0326-SM-3K2B1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00357
K562_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150976
hsa-miR-27b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-DZ-6135-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary ciliary dyskinesia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.289
A549_MLN8054_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177675
ZNF384	ENCODE Transcription Factor Targets	1.0	null
hematopoietic system disease	GWASdb SNP-Disease Associations	1.0	0.119247
A549_MK-0752_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180904
intermediate stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.39342
Perturb_2084_KD_Pan3_SRP087494	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PMC4219345-1471-2121-14-52-S5.xlsx-Sheet1-Transcript_bound_to_BORIS_in_6dN_and_down-regulated_during_differentiation_CTCFL	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_6640_KD_ZBP1_SRP298473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.39931
STAT4	ChEA Transcription Factor Targets	1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Primary somatosensory area, lower limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.17461
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88107
BL6912 (CEP152)	NURSA Protein Complexes	1.0	null
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL2-Unnamed_0_TAL2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K36me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CL-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.926496
decreased sperm progressive motility	MGI Mouse Phenotype Associations 2023	1.0	null
GSE167474_2_v_0_naa40_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_MAP_AA-SYMBOL_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
OPM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15272
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC10684515-41467_2023_43264_MOESM7_ESM.xlsx-HOXA9_ChIP-seq_peaks_in_SEM-Closest_Gene_HOXA9	Rummagene Transcription Factor Associations 2026	1.0	null
STAT3-19079543-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0326-SM-4AT5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62636
GSE188870,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Busulfan_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0206315
COLO678	CCLE Cell Line Gene CNV Profiles	-1.0	-1.95678
H3K36me3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAGE_knockout_267_GDS3755	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.44154
NANOG-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
A549_Tie2 kinase inhibitor_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188415
renal cell carcinoma	GWASdb SNP-Disease Associations	1.0	0.698242
GSE218356_1_v_0_cited1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE189653,GSE203344_5_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_SGI-1776 free base_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0122461
CAL-12T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.62136
hsa-miR-1200	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
A549_Temsirolimus_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145335
Pax7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	48.3509
cytoplasm	GO Cellular Component Annotations 2015	1.0	null
hsa-miR-3118	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE247862,GSE247863_0_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4701-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GSE223008_9_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FRA1	MotifMap Predicted Transcription Factor Targets	1.0	null
Levobupivacaine (hydrochloride)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0203097
A549_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194363
GTEX-S95S-0726-SM-4B64H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.893982
MCF7_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.02976
kidney cancer	GWASdb SNP-Disease Associations	1.0	0.442605
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE224096_1_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BT-483	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.52705
GTEX-P4PP-0926-SM-48TBZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08674
hsa-miR-381	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
ZNF675	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.6089
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WFG8-0326-SM-4LVN4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12206
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9RF-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE146074_0_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Givinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0251775
Radiation-induced brain injury in nasopharyngeal carcinoma	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.822185
MCF7_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130774
GSE226249_5_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEL4-1226-SM-447A4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16046
MCF7_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014829
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_ALL-GENE_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
Paramedian lobule, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.42338
GSE115542_5_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H1694	COSMIC Cell Line Gene CNV Profiles	1.0	2.10038
GSE184902_3_v_1_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE89018_12_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.2075
neuroectodermal neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.295523
PMC5651844-41467_2017_1173_MOESM4_ESM.xlsx-sheet_1-Supplementary_Data_1_Down_regulated_genes_in_YEATS2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
r3 part of lateral vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02819
rheumatoid arthritis	GWASdb SNP-Disease Associations	1.0	1.19386
episupraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.08602
GTEX-RWS6-0926-SM-47JXE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20696
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48315
GSE196104,GSE196106_2_v_0_vsx2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.94065
DLX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4963
SLFN11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33571
immune system disease	GWASdb SNP-Disease Associations	1.0	0.149976
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141488
ESS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A6YQ-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.39708
CBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11433
GTEX-WWYW-1326-SM-3NB2S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1502
abnormality of the female genitalia	GWASdb SNP-Phenotype Associations	1.0	0.168805
Meckel syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-0.825898
SW 1990	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.43104
Inner medullary collecting duct cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.797
Kidney Chromophobe_KICH_TCGA-KL-8341-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64429
Crus I, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08613
A549_GSK1070916_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160051
A549_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019123
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.623
GTEX-X8HC-0726-SM-46MWG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17273
hsa-miR-3157-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10491
Prostate adenocarcinoma_PRAD_TCGA-EJ-5525-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU-C2B	COSMIC Cell Line Gene Mutation Profiles	1.0	null
breast carcinoma	GWASdb SNP-Phenotype Associations	1.0	0.599613
PKN2	Kinase Library Serine Threonine Kinome Atlas	1.0	null
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55436
r7 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16379
dorsal part of m2A	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.85195
Sarcoma_SARC_TCGA-X6-A7WC-01A-12R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3382
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.827632
MCIXC	DepMap CRISPR Gene Dependency	1.0	4.65448
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.892422
PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-DMOG_-_HIF1A-gene_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-1622-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XPT6-1626-SM-4B655	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08706
r6 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48721
hsa-miR-520a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.336728
Blastocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.002
GSE179868,GSE180330_1_v_0_ddx21_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Fedratinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00934087
Lung squamous cell carcinoma_LUSC_TCGA-56-8504-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRF	ENCODE Transcription Factor Targets	1.0	null
placenta	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.8853
PMC9038526-mmc1.xlsx-postCOVID_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
dorsomedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.05756
GSE154074_2_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XLM4-1526-SM-4AT6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72456
Hydroxyfasudil_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0149871
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00453
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_SBP_AA-GENE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Primary somatosensory area, lower limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.5377
Perturb_6985_OE_Ppp3cc_SRP321708	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MDAMB436	CCLE Cell Line Gene Expression Profiles	-1.0	-1.70238
GTEX-Q2AI-1226-SM-48U14	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68662
GSE112860_0_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
spindle pole	GO Cellular Component Annotations 2015	1.0	null
cytoplasmic part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51117
GSE126621,GSE126920_1_v_3_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OHPM-2126-SM-3LK75	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54681
17880687-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GSE190316,GSE190324_6_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Golgi apparatus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
A549_Costunolide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0245787
UNCX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5332
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13585
ME-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
layer 1 of AOV cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29794
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE184884_4_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12694
Primary immunodeficiency disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.006
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A0YN-01A-21R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_SRT2104_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0282176
Epilepsy	DisGeNET Gene-Disease Associations	1.0	null
GSE184479_1_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EMX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7512
Perturb_12341_KD_METTL18_SRP235648	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
inner CP in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37633
GTEX-UPK5-1626-SM-4JBHI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27477
SCC-9	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.26082
TFAP2A	ChEA Transcription Factor Targets	1.0	null
musculoskeletal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.256228
MCF7_Ofloxacin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140855
SEMA6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35925
HEY	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE203308_14_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Oxaprozin_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00901059
GSE88819_1_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE237040_6_v_5_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Microtubule organizing center	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.623
arl6	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.846
reproductive system phenotype	MGI Mouse Phenotype Associations 2023	1.0	null
GTEX-X261-0126-SM-3NMD6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89845
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_Hesperadin_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171556
GTEX-QDVJ-0226-SM-2I5FV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858664
Osimertinib (mesylate)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0187294
A549_Mocetinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195783
Demeclocycline_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0192042
GTEX-WCDI-0008-SM-47JYE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18725
Thyroid stimulating hormone levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.60458
PMC9859043-elife-78421-supp9.xlsx-LHX8_P-Gene_symbol_LHX8	Rummagene Transcription Factor Associations 2026	1.0	null
GSE95077_5_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bimatoprost_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0212128
icSARS-Cov_Day4_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.02533
Sarcoma_SARC_TCGA-VT-A80J-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05577
K562_CYC116_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159287
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.295
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NUGC-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.08515
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_MAP_AA-GENE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-POYW-0826-SM-2XCEM	GTEx Tissue Sample Gene Expression Profiles	1.0	2.02845
Cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.102
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_UNC0631_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147307
MAX	ENCODE Transcription Factor Targets	1.0	null
A549_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222454
A549_Raltitrexed_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146421
GSE242367_1_v_0_dpp9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MB-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5753-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HL60	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32681
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-7966-11A-01R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_IOX2_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167536
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.925139
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KE37	CCLE Cell Line Gene Expression Profiles	1.0	1.6036
GSE132369,GSE132371_5_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WHSB-1326-SM-3LK6W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947709
GSE145915_3_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223008_0_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RU72-0626-SM-46MUI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949042
OAW28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.916789
lung carcinoma	GWASdb SNP-Disease Associations	1.0	0.375034
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MGST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15113
PHOX2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5658
A549_TMP195_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0213981
PMC9380317-13045_2022_1327_MOESM3_ESM.xlsx-Table_S4-Table_S4_Top_500_differentially_modified_gene_bodies_between_AA_and_EA_patients_with_MM_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
SLC39A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00528
Nafamostat (mesylate)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0140518
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE215086_0_v_2_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5169-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
16207381-Table1Sa	GeneSigDB Published Gene Signatures	1.0	null
Adenine_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0284744
MCF7_FLLL32_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147731
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.006
GSE157894_2_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Olanzapine_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.018785
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877818
GTEX-REY6-0526-SM-2TF5M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982726
GSE235066_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242647_2_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193258,GSE193259_5_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PPIL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27579
Tucidinostat_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.013051
A549_PD98059_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177976
PMC3355086-pgen.1002728.s003.xlsx-Tabelle1-HEY1_downregulated_HEY1	Rummagene Transcription Factor Associations 2026	1.0	null
Medial amygdalar nucleus, posterodorsal part, sublayer b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12733
GSE151829,GSE151831_5_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4415-01A-22R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181562
A549_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017791
GSE95077_1_v_0_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE165122_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
preoptic region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.943646
primary motor cortex (area M1, area 4)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16696
GSE138019_4_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.29666
SG in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.50986
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12205070-41467_2025_61222_MOESM5_ESM.xlsx-DE_markers_TAL1_scenic_reductio-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WFG7-0326-SM-3GILI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85293
RKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE164874_5_v_4_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
posterior paraventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1612
testis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
Fluvoxamine_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0200505
MCF7_PCI-34051_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133286
A549_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161046
Parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32537
hippocampus (hippocampal formation)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.97664
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3091
A549_CUDC-101_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180862
MCF7_Fasudil_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166938
A549_Danusertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210318
GSE234340_1_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsolateral part of m2A	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70422
Lung adenocarcinoma_LUAD_TCGA-55-6642-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE138938_1_v_4_foxp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Vilanterol_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0188076
GSE216147_0_v_3_rbm20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
vomeralnasalorgan.VMO.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.833073
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23054
cognitive disorder	GWASdb SNP-Disease Associations	1.0	0.550393
KYSE-50	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_Filgotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0217468
MCF7_CEP-33779_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125183
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15272
H3K36me3_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE211955_1_v_0_jmjd4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.70446
RKN	DepMap CRISPR Gene Dependency	1.0	2.6733
NCIH929	CCLE Cell Line Gene Expression Profiles	1.0	1.54121
MCF7_Bisindolylmaleimide IX_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0114682
AKT3	Kinase Library Serine Threonine Kinome Atlas	1.0	null
MCF7_UNC0379_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141917
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.875088
PHAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03762
PMC8787225-Data_Sheet_1.xlsx-STable_2_DEG-Supplementary_Table_2_1150_up-_and_down-regulated_differential_expressed_genes_upon_GATA2_activation_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WWYW-0926-SM-3NB2Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00093
NB17	DepMap CRISPR Gene Dependency	1.0	5.32771
NCIH1573_LUNG	CCLE Cell Line Proteomics	1.0	4.47685
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_2-Methoxyestradiol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142556
Prostate adenocarcinoma_PRAD_TCGA-EJ-7330-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
testis_7f	HPA Tissue Sample Gene Expression Profiles	1.0	0.937009
GTEX-PX3G-0008-SM-48U2L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30099
PMC4944136-srep28995-s2.xls-ARGFX-gene_ARGFX	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S3XE-1526-SM-4AD5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33006
abnormal spermatogenesis	MGI Mouse Phenotype Associations 2023	1.0	null
SYK_druginhibition_286_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.60856
endometrial cancer	GWASdb SNP-Disease Associations	1.0	0.442605
MCF7_SRT1720 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193214
AMO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.33955
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.989999
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.8386
mantle zone of PHyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.84371
A549_S3I-201_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187002
supramammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.946836
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.837262
GSE188458_2_v_4_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Disulfiram_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173768
AtrioventricularNode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.4392
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.1968
A549_Alisertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184461
malignant neoplasm of the central nervous system	GWASdb SNP-Phenotype Associations	1.0	0.295523
A549_Danusertib_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170036
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
MSK1	Kinase Library Serine Threonine Kinome Atlas	1.0	null
ChIP_STAT3_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_SRT3025 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153794
GSE110268_0_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_PF-3845_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195141
MIXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5201
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44409
CHD2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nasopharynx carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
neoplasm of the central nervous system	GWASdb SNP-Phenotype Associations	1.0	0.260489
Prostate adenocarcinoma_PRAD_TCGA-CH-5752-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BL1739 (CARM1)	NURSA Protein Complexes	1.0	null
GSE158969_1_v_2_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-1245	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.861602
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HUC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.582
A549_Dacinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00986598
Kidney renal papillary cell carcinoma_KIRP_TCGA-4A-A93Y-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210101,GSE210114_8_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Costunolide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.027249
Lung squamous cell carcinoma_LUSC_TCGA-77-A5G6-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Male infertility due to acephalic spermatozoa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.733
organelle part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54624
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-302b	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
A549_Fasudil_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132833
A549_AC480_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153836
GSE182680,GSE182683_7_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212064
G-401 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.561
posterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.37531
MCF7_Tozasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0226698
GSE151090_0_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126776_0_v_1_pelp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_CYC116_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164316
substantia nigra, pars compacta, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17286
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02726
A549_Meprednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153935
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.0246
A549_ZM 447439_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145787
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01536	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.825431
GSE110178_2_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Idioblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.96
cytoskeletal part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
GSE182680,GSE182683_5_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hs27	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.036
GTEX-SNOS-1126-SM-4DM67	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81147
RAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5845
ventral paracommissural tectal nucleus, m1 part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13972
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.952888
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE235701,GSE261434_2_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
JAZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37532
Intraciliary transport particle B	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.108
Primary somatosensory area, upper limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.84126
Secondary motor area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07183
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE233679_5_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bimatoprost_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0203444
shell of SCH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33351
microtubule organizing center part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PKG2	Kinase Library Serine Threonine Kinome Atlas	1.0	null
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
A549_Gandotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157479
GSE228263_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Decitabine_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141998
A549_S3I-201_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154126
MCF7_Alisertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.027721
GTEX-XAJ8-1326-SM-47JYT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05658
GSE133213_6_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_11_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Luminespib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00931919
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205127
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03369
abnormal glucose homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.195321
N4BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05546
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.932786
internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE149442_1_v_0_gdpd3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00661
JcPL part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.05042
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
COCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42186
hsa-miR-575	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
DMS-53	COSMIC Cell Line Gene Mutation Profiles	1.0	null
IM-95	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.43102
Docetaxel (Trihydrate)_C32	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0190767
Flp-In-T-REx cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.697
GTEX-XMK1-2026-SM-4B65K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28021
BL2454 (ZFPM2)	NURSA Protein Complexes	1.0	null
GSE182680,GSE182683_5_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_ITSA-1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.024617
NCI-H1793	COSMIC Cell Line Gene Mutation Profiles	1.0	null
JAR	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Dacinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0102068
GTEX-SUCS-1326-SM-4DM5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947487
abnormality of the face	GWASdb SNP-Phenotype Associations	1.0	0.098677
USP2_KO_GSE43517_20_mouse_kidney	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE57875_1_v_0_hnrnpl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10534007-Table_3.xlsx-S8_unique_down_MSC_V-345_elements_included_exclusively_in_VMCUB1_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
A549_ZM 447439_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161652
GTEX-WY7C-2126-SM-3NB2R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06133
GSE130383_1_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE81803,GSE81912_4_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE121866_0_v_2_six4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-R53T-0426-SM-48FEM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.962459
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-BI-A0VS-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r1 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20627
CHEMBL217125	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.58
GSE226249_5_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Thymol_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0223914
Hemispheric regions	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24553
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.73923
SLR21	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73132
MCF7_Linifanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174771
outer SZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.848755
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6775
H3255	COSMIC Cell Line Gene CNV Profiles	1.0	2.10038
SOX2	ChEA Transcription Factor Targets	1.0	null
GSE92434_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235066_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DU 145	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Gallic acid (hydrate)_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0164309
A549_Dacinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.012688
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-PX3G-0926-SM-48U12	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97085
PMC6426138__F6	PFOCR Pathway Figure Associations 2024	1.0	null
PMC4407272-elife06857s002.xlsx-501M_BRG1-MITF_ComDown-List-Ensembl_gene_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R55C-1426-SM-48FED	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53575
L-Eflornithine (monohydrochloride)_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0203658
GSE201381_0_v_1_bhlhe22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.97431
MCF7_MK-5108_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163372
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.912052
Pyridoxine (hydrochloride)_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0350404
GTEX-S95S-1426-SM-2XCDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.917367
Adrenocortical carcinoma_ACC_TCGA-OR-A5LE-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4668-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
cuneiform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.977528
GSE221577_1_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
gamma-tubulin small complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.046
A549_M344_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0336919
Nucleus ambiguus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03227
Sperm flagellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.468
MCF7_Sorafenib Tosylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138811
GRM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.9708
NCI-H2461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04454
GSE81803,GSE81912_3_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE123825_0_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GF-A4EO-06A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.833889
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220662
MOV10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3951
K562_Toremifene Citrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205751
SNU1272	CCLE Cell Line Gene Expression Profiles	-1.0	-1.57491
PMC6097700-pgen.1007515.s008.xlsx-S2_Table-S2_Table_SATB2_Cort_gene-set_list_SATB2	Rummagene Transcription Factor Associations 2026	1.0	null
hsf1_19179333_rko_colon_carcinoma_lof_human_gpl6244_gse12762	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.163186
Hydroxyfasudil_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0221372
OVMANA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.52705
NCIH1694	CCLE Cell Line Gene CNV Profiles	1.0	2.16998
OVMANA	CCLE Cell Line Gene Expression Profiles	-1.0	-1.49618
GTEX-UPK5-2026-SM-4JBIM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986511
Orbital area, medial part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66315
A549_Rucaparib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167914
mIMCD-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.588
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167089
retroreuniens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66378
dorsal preisthmic part of periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.85563
Coronary Artery Disease	dbGAP Gene-Trait Associations	1.0	0.249192
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.1167
Rectal Mucosa Donor 31	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.06607
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
caudal (posterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.877571
496100549_FWM_no dementia_TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.35301
Tuberomammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03614
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PKACA	Kinase Library Serine Threonine Kinome Atlas	1.0	null
SUDHL8	CCLE Cell Line Gene Expression Profiles	1.0	1.45464
Prostate adenocarcinoma_PRAD_TCGA-FC-A4JI-01A-11R-A250-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_CUDC-907_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00561943
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE152432_6_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.902769
CEBPB	ChEA Transcription Factor Targets	1.0	null
JUND	JASPAR Predicted Transcription Factor Targets	1.0	null
Perturb_4343_OE|KD_MIR9/MIR124|RN7SK_SRP271664	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.207
Irinotecan (hydrochloride)_SW480	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0347028
anterior hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0599
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.93963
GSE228894_0_v_1_rnmt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
estradiol_mus musculus_gpl4134_gse23241	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
icSARA deltaORF6_60Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.53628
GSE198165,GSE198166_7_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00651
Fusidic acid_SW480	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0213148
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1338
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.69232
Lung adenocarcinoma_LUAD_TCGA-95-7562-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
midbrain raphe nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.57938
Ciliary cap	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.003
496100505_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.46286
hsa-miR-4683	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05162
nervous system disease	GWASdb SNP-Disease Associations	1.0	0.076869
GSE111385_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01522
CD4_Memory_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.70436
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.57
Achilles bursitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.332
microtubule organizing center	GO Cellular Component Annotations 2015	1.0	null
CHRNA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01341
organelle part	GO Cellular Component Annotations 2015	1.0	null
gonad	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
interstitial nucleus of Cajal, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.33964
Verteporfin_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0188893
RNF141	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81142
GTEX-RVPV-0008-SM-47JYW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93139
K562_Disulfiram_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0346337
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_15_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
Rectum adenocarcinoma_READ_TCGA-F5-6814-01A-31R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SARC9371	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-7109-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7079-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_CUDC-101_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138513
GSE239688_4_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QV44-0826-SM-2S1RG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84922
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7049-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE96641_3_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_INO-1001_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0231079
ESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9234
KYSE-270	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JD-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17816
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13735
MCF7_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139514
MCF7_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216998
TUHR4TKB	CCLE Cell Line Gene Expression Profiles	-1.0	-1.59392
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE125782_0_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Daphnetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167577
HOXA7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1988
ventral entopeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52644
Usp22_DEPLETION_GDS4973_284_mouse_E14 embryonic stem cells (ESCs)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
hsa-miR-93	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.5241
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE144347_1_v_0_crnkl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_JNJ-7706621_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019086
artery disease	GWASdb SNP-Disease Associations	1.0	0.205552
cellular_component	GO Cellular Component Annotations 2015	1.0	null
A549_ENMD-2076 L-Tartaric acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125267
A549_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0252584
PMC6996923-elife-46981-supp4.xlsx-KO_Up_Only_Vs_OCT4-Column_ID_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160817_7_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_CUDC-101_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143551
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.9145
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04217
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormality of erythrocytes	GWASdb SNP-Phenotype Associations	1.0	0.281419
MCF7_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223079
PMC12512047-Table2.pdf-2-TSC22D1-AS1_TSC22D1	Rummagene Transcription Factor Associations 2026	1.0	null
VZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.56861
Testicular cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.951
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
KNS42_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	2.21913
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.991397
GSE119694_1_v_0_lifr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_CUDC-907_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0119886
HCE-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4815-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.76054
ventral part of PHyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.84465
A549_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155031
Cortical amygdalar area, posterior part, lateral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5179
A549_Fasudil_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.02582
isthmic roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02305
PMC3500769-srep00875-s3.xls-AP1-Time_0_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
TFAP2E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11367
paracentral lobule, anterior part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.64804
Sirt1_OE_GDS2658_140_mouse_heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE117042_1_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ABCF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11593
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.55139
abnormality of the endocrine system	GWASdb SNP-Phenotype Associations	1.0	0.203195
H3K4me1_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6950-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE203308_4_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CDX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1578
COV644	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.7113
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBEC-0126-SM-4GIDT	GTEx Tissue Sample Gene Expression Profiles	1.0	2.0097
RIOK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45917
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.48815
PMC8528285-pbio.3001085.s010.xlsx-Fig_S7C-GENE_LIST_UPLOADED_TO_ENRICHR_MAX_KO_TESTES_627_GENES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
superficial stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33711
GTEX-XV7Q-0926-SM-4BRVQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.964579
Lung adenocarcinoma_LUAD_TCGA-78-7536-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4217-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-P44H-0226-SM-2XCEU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42308
Dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17768
GTEX-V1D1-2226-SM-3NMAX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879065
K562_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179579
Lung adenocarcinoma_LUAD_TCGA-86-6851-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
p3 portion of the substantia nigra pars reticulata	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35353
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-5248-01A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21246
DV90_LUNG	CCLE Cell Line Proteomics	1.0	8.86923
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.848377
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0256
GSE88819_3_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ADAM8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04677
STAT6	MotifMap Predicted Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7402-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Tucidinostat_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0154076
Retrosplenial area, dorsal part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14114
lateral subdivision of area 9	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22399
USF2_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFJO-0226-SM-3GIKW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846024
Perturb_491_KO_LITATS1_SRP363523	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PMC4521181-oncsis201520x8.pdf-58-HOXB13_HOXB13	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Ruxolitinib_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0113958
A549_Tazemetostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206151
H3K79me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_GSK-LSD1 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152906
VMRCRCW	CCLE Cell Line Gene CNV Profiles	-1.0	-1.71396
G61	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.901992
Mitoxantrone (dihydrochloride)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0250275
9+2 non-motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.616
MCF7_Cyclocytidine HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0224882
ST486	CCLE Cell Line Gene Expression Profiles	1.0	1.35853
A549_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0269563
A549_CUDC-101_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.011721
Centriole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.546
Astral microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.725
GSE175787_8_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
inner SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.839441
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IS-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymphoid cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150204
DG-75	COSMIC Cell Line Gene Mutation Profiles	1.0	null
intermediate stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1029
GTEX-P4PQ-2626-SM-33HC9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06935
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.887188
L1236	CCLE Cell Line Gene CNV Profiles	-1.0	-1.86368
lateral septal nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0779
GSE195559_8_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61446
peduncular part of dorsomedial hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39453
hsa-miR-1248	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Perturb_4308_KO_FOXM1_SRP328179	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Penis_Foreskin_Keratinocyte_Primary_Cells_skin03	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.04267
Ciliary membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.643
NARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10327
496100559_FWM_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.26833
K562_Regorafenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01478
PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_up-regulated_in_Myc_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
graves disease	GWASdb SNP-Phenotype Associations	1.0	1.38972
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21523
A549_CUDC-907_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151407
A549_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015653
bone disease	GWASdb SNP-Disease Associations	1.0	0.177073
D423MG	DepMap CRISPR Gene Dependency	1.0	3.96174
Microtubule end	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.886
A549_JQ1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124858
OSC-19	COSMIC Cell Line Gene CNV Profiles	1.0	2.10038
A549_JQ1_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.023327
GSE146074_10_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NEUROG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5396
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE140651,GSE140653_2_v_7_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4694-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
GTEX-XXEK-0926-SM-4BRWH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33354
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_14_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.28892
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3500769-srep00875-s3.xls-GATA3-Time_4_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.91941
type 2 diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.592944
GSE188832,GSE188835_0_v_1_irf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145915_5_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
amygdaloid complex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.36789
Urinary bladder cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.178
K562_Ivosidenib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.022499
GSE143643,GSE143644_2_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.33461
GSE161800_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_PHA-680632_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128939
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7377-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LS 180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Male infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.474
A549_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0204348
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-2626-SM-4BOQ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955791
PMC3500769-srep00875-s3.xls-PAX2-Time_1_PAX2	Rummagene Transcription Factor Associations 2026	1.0	null
testis_7a	HPA Tissue Sample Gene Expression Profiles	1.0	0.906848
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958874
Female pronucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.267
PMC4595011-pgen.1005555.s001.xlsx-MITF_DOWN-regulated-Gene_name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-548ah	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
abnormality of the uterus	GWASdb SNP-Phenotype Associations	1.0	0.333763
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6873-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE186483_6_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222139
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A681-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Intraciliary transport particle A	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.949
mRNA_YY1_22210892	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
NCI-H1299	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.880243
GTEX-XOT4-0526-SM-4B66O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20817
DMRTC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5683
MCF7_Barasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180974
striatum_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.66443
LS 174T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
oculomotor nuclear complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02064
gracile nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.04469
CAL62	CCLE Cell Line Gene CNV Profiles	-1.0	-1.70804
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2IP-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE186440,GSE186443_1_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RN64-2326-SM-48FDW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43272
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.904
GSE114992,GSE114993_9_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SK-MEL-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_Navitoclax_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160384
GTEX-PW2O-0126-SM-48TC8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.19621
follicle-stimulating hormone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.582
GSE167324_2_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	55.7356
NR3C1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
Embryonic carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.918
hsa-miR-299-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
Ansiform lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20525
primary motor cortex (area M1, area 4)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.886879
MCF7_Ivosidenib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181992
GSE125153_2_v_0_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Obatoclax Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0117409
Irinotecan_LS 180	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0121086
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16189
Oxaliplatin_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0223611
A549_Aminoglutethimide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147788
A172	DepMap CRISPR Gene Dependency	1.0	5.27522
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19211
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
dorsal part of m1A	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02744
GTEX-RWSA-0008-SM-47JYX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69567
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.43692
PcPL part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.41512
Palmatine (chloride)_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.029851
amygdaloid complex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.967209
A549_Cyclocytidine HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0270294
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UJMC-0008-SM-4IHKK	GTEx Tissue Sample Gene Expression Profiles	1.0	2.25311
GSE198165,GSE198166_7_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lateral part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25108
GSE110268_0_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
Perturb_13444_KD_Taf4_SRP119047	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.41674
PMC11839389-PUL2-15-e70058-s003.xlsx-FLF_TBX4_mergeRNAseqChIPseq-symbol_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.830995
HS604T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47957
A549_Cerdulatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120707
MEF2A	JASPAR Predicted Transcription Factor Targets	1.0	null
K562_Lomustine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172754
Lung squamous cell carcinoma_LUSC_TCGA-22-1011-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_12198_KD_XPA_SRP310546	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
superficial stratum of PSPa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52507
GTEX-P44H-0011-R10A-SM-2XCEK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.888703
superficial stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.27482
GTEX-NL3G-0008-SM-4E3JX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21949
A3KAW	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57011
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Daphnetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01303
Rectum adenocarcinoma_READ_TCGA-EI-6917-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lenalidomide (hemihydrate)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0226637
GSE96641_1_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF35	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1768
A549_Ki8751_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184258
A549_Tazemetostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170915
A549_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138066
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.27294
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.94202
GSE228017_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Linifanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155971
GTEX-OXRL-0326-SM-2I3F2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22615
NCI-H661	COSMIC Cell Line Gene Mutation Profiles	1.0	null
periventricular stratum of m1AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35141
MCF7_PF-3845_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0234651
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51R-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Thalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208958
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intermediate stratum of m1AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13909
lung disease	GWASdb SNP-Disease Associations	1.0	0.610694
A549_Temsirolimus_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128611
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_HA-SYMBOL_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AH-1826-SM-2S1Q2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48558
Senicapoc	DeepCoverMOA Drug Mechanisms of Action	1.0	0.41
A549_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0222883
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SK-UT-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A4JB-01A-51R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPMI8226	CCLE Cell Line Gene Expression Profiles	1.0	1.63742
hsa-miR-17	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
PMC7946393__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Weight Gain	CTD Gene-Disease Associations	1.0	1.16137
Seckel syndrome 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.492
r9 part of spinal vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10892
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44116
D542MG	DepMap CRISPR Gene Dependency	1.0	2.7537
A549_Raltitrexed_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149384
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70706
GSE108326_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OIZI-0726-SM-2XCEI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834041
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42952
verob4	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.759
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
inferior colliculus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.942692
A549_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179934
PMC10794847-mmc6.xlsx-PIAS1_KD_down-Table_S5_Genes_differentially_expressed_with_PIAS1_knockdown_in_keratinocytes_cultured_in_the_differentiation_condition_Related_to_Figure_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Vandetanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0246396
K562_Entacapone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189397
GSE180200,GSE180201_2_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Aminoglutethimide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145162
A549_Fasudil_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138413
HS695T	CCLE Cell Line Gene Expression Profiles	-1.0	-2.34068
PMC9691391-7945884.f3.pdf-82-ENSG00000177426_TGIF1	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4513	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
abnormality of the common coagulation pathway	GWASdb SNP-Phenotype Associations	1.0	0.770746
Glycolate oxidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.531
GTEX-OXRL-2126-SM-3NM98	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45224
GSE143994_2_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AKT2	Kinase Library Serine Threonine Kinome Atlas	1.0	null
GSE130396_1_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ETV5::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9025
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Nearest_Ensembl_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146840,GSE146842_3_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HSF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.3302
TP53I13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45231
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.05535
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.91802
F-9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.21
BBSome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.82
Tofacitinib_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0240146
Hoxd13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.616
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.43104
periventricular stratum of JcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.05214
Familial gestational hyperthyroidism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.018
Hemoglobins	dbGAP Gene-Trait Associations	1.0	0.225557
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.7576
MCF7_PF-573228_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015024
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Retrosplenial area, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01201
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8481886-Table_1.xlsx-A_subsets-iMSC_fetal_MSC_UC_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_MK-5108_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0343907
A549_KW-2449_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227979
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.48795
hsa-miR-519d	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
GSE223008_11_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WL46-0126-SM-3TW8I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831939
TLX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7003
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.96596
A549_Streptozotocin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0224031
glioblastoma multiforme	GWASdb SNP-Disease Associations	1.0	0.698242
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-7966-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TFAP4::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.1391
nutrition disease	GWASdb SNP-Disease Associations	1.0	0.387281
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.39923
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_INO-1001_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207208
PMC12205070-41467_2025_61222_MOESM5_ESM.xlsx-DE_markers_TAL1_scenic_reductio-gene_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
sensory system disease	GWASdb SNP-Disease Associations	1.0	0.591098
GSE228413_0_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Thiotepa_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.025849
A549_AZD1480_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195295
CLEC11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86553
doxorubicin_homo sapiens_gpl6947_gse25741	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
22RV1	DepMap CRISPR Gene Dependency	1.0	11.3855
GSE165548_2_v_13_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-4593-01A-21R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.866209
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40111
GSE151119_3_v_0_hsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-Q734-0626-SM-2I3EF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15437
A549_Hesperadin_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0217571
GSE218907_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CEBPB-23403033-LIVER-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.56175
K562_AG-14361_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200679
GSE152055_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE68155_3_v_2_gpr3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_UNC1999_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0286174
GSE110268_2_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S4Q7-1226-SM-4AD5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26691
Bach1::Mafk	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.2632
A549_Alisertib_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139721
A549_AG-490_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227265
K562_A-366_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196756
TTK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58584
hTERT-RPE1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.968
OPM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.34783
PRRX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7714
PMC4407272-elife06857s002.xlsx-501M_BRG1-MITF_ComDown-List-Gene_name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
PARP	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE220806_1_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11239565-uxae032_suppl_supplementary_data_s1.pdf-5-ZNF76_ZNF76	Rummagene Transcription Factor Associations 2026	1.0	null
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.44287
H3K79me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PX3G-0826-SM-48TZS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908588
BL119 (ATR)	NURSA Protein Complexes	1.0	null
CAKI2_KIDNEY	CCLE Cell Line Proteomics	1.0	3.05712
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.77792
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07363
EB1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00595
WM1799	DepMap CRISPR Gene Dependency	1.0	3.97869
NCIH28	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37704
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE215086_0_v_1_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_HA-GENE_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
STAC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07824
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48432
PMC12178937-mmc6.xlsx-D_MAFF_KDvsD_C_deg_all-gene_id_MAFF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QDT8-0626-SM-48TYW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14559
GTEX-SJXC-0726-SM-2XCFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4891
A549_Ellagic acid_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206495
PMC12152148-41420_2025_2541_MOESM3_ESM.xlsx-AR-IP-DHT_peak-gene-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02072
GSE254649_3_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.861561
GTEX-S33H-1226-SM-4AD69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04445
Hic1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.3776
A549_Momelotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167017
K562_Trichostatin A_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0252584
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ALX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6546
CMK115	DepMap CRISPR Gene Dependency	1.0	2.43189
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.50953
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
FXR	MotifMap Predicted Transcription Factor Targets	1.0	null
A549_Barasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0273099
TDP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26006
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.26447
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4983-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU-175	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TOMM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40986
UNC13D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04574
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10096
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A4-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0274349
A549_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240106
GTEX-PWOO-0626-SM-48TZH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03608
MAX::MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9524
A549_AT9283_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0217458
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.42183
Temuterkib_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0126899
MCF7_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0305792
Entrectinib_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0128091
male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Bone marrow cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10055
Hexylresorcinol_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0227326
GTEX-OOBJ-2126-SM-3NB1N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27208
GSE158456_2_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TOV-112D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.82278
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_x_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.978601
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Anterior olfactory nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.762
abnormality of the systemic arterial tree	GWASdb SNP-Phenotype Associations	1.0	0.148587
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851926
r9 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16568
hsa-miR-448	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
TET1-21490601-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
A549_Motesanib Diphosphate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0370608
GTEX-V1D1-0008-SM-4JBIJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25257
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.23584
GSE223008_0_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ETV5::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2887
Prostatic Neoplasms	CTD Gene-Disease Associations	1.0	1.16833
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZW-06A-12R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH889	CCLE Cell Line Gene CNV Profiles	1.0	2.85094
GSE169356_0_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SIRT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30091
primary auditory cortex (core)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.920253
inherited metabolic disorder	GWASdb SNP-Disease Associations	1.0	0.193744
GTEX-XQ8I-0126-SM-4BOPL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19758
testis	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.904249
SG in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.35007
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Paclitaxel_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0343659
GTEX-S32W-2326-SM-2XCAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36978
SUDHL6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.17618
Outer dense fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.7
magnocellular superficial hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15523
endometrial carcinoma	GWASdb SNP-Disease Associations	1.0	0.698242
RHEBL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04609
Bexarotene_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0221884
MORCPR	CCLE Cell Line Gene CNV Profiles	-1.0	-1.66511
Spindle pole	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TMEM88_KD_GSE43805_682_human_hES cells differentiated along the cardiac lineage	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
K562_Gandotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153168
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-1.45363
Shox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.1992
MT-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
MCF7_EED226_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181106
Central nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.202
PTRH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13619
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D9-01B-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
triangular septal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72703
mantle zone of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24829
hsa-miR-524-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.71854
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7161-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GSE218060_1_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-genes_with_only_SALL4_peaks-Protein-coding_genes_that_show_only_CUT_RUN_peaks_with_2_SALL4_antibodies_and_no_other_antibodies_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE196343_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-IK-7675-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10528072-NIHMS1928302-supplement-5.xlsx-NEUROD1-target_genes-AANAT_NEUROD1	Rummagene Transcription Factor Associations 2026	1.0	null
decreased fertilization frequency	MGI Mouse Phenotype Associations 2023	1.0	null
Mitotic spindle pole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.354
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.43128
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE195568_2_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Quercetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232919
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Azacitidine_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210036
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89207
A549_Andarine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.029545
Brain Lower Grade Glioma_LGG_TCGA-S9-A7J0-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.942177
HNF4	MotifMap Predicted Transcription Factor Targets	1.0	null
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.7024
Primary somatosensory area, lower limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.6775
GAMG_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	4.57054
PMC6828764-41419_2019_2062_MOESM2_ESM.xlsx-GATA3_UTX_promoter_gene-ENSEMBL_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
A549_JQ1_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0102369
K562_SB431542_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210585
Motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.862
Demeclocycline_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0268375
E2F4	ENCODE Transcription Factor Targets	1.0	null
Stomach Smooth Muscle	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.28456
RCOR1	ENCODE Transcription Factor Targets	1.0	null
Post bronchodilator FEV1/FVC ratio	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.552288
MCF7_Costunolide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191477
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24065
GSE147662_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03364
GSE233679_5_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180508
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.50521
NCI-H345	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE223008_4_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mitoxantrone (dihydrochloride)_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0212833
GTEX-Q734-2026-SM-3GADA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00884
GSE112860_0_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.866658
GSE163052,GSE163198_4_v_7_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Palmatine (chloride)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.033706
neoplasm of the breast	GWASdb SNP-Phenotype Associations	1.0	0.599613
A549_TGX-221_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136569
GTEX-XPT6-2026-SM-4B64V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.999353