association dataset threshold value standardized value superficial stratum of r8Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23504 skin_5f HPA Tissue Sample Gene Expression Profiles 1.0 1.43979 dentate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.00969 ventrolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.837074 Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UGT8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25468 FOXP2 ChEA Transcription Factor Targets 1.0 null GSE138019_1_v_5_nudt12_mouse RummaGEO Gene Perturbation Signatures 1.0 null Inflorescence stalk TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.015 PURB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30323 GTEX-SIU8-0526-SM-2XCDP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23433 H3K27me3_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF764 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20168 temporal lobe TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null HNRNPA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69445 POU2F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72606 FOS::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.4157 GTEX-WYVS-2126-SM-3NMA3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.37636 TFEB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.9802 HFE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00487 posterodorsal tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40386 dorsolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.947475 orbital frontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.38217 AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null GTEX-QDT8-0011-R11A-SM-32PKD GTEx Tissue Sample Gene Expression Profiles 1.0 1.24039 ACTL6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.99393 GTEX-X585-0011-R11B-SM-46MUZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.25026 NOS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69046 spleen HPA Tissue Protein Expression Profiles -1.0 -0.880199 GTEX-RVPU-0008-SM-3NM8B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29959 POLG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68588 MDM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10934 Perturb_11172_KO_Klf15_SRP186285 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.78977 CTCF_GM12870_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMD1-2826-SM-4AT5F GTEx Tissue Sample Gene Expression Profiles 1.0 0.994158 HCC1937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.5517 Prostate adenocarcinoma_PRAD_TCGA-J4-A67S-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CAMA1 CCLE Cell Line Gene Expression Profiles 1.0 1.57392 GSE155031_5_v_3_dextran_human RummaGEO Drug Perturbation Signatures 1.0 null Temporal lobe TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 RF-48 COSMIC Cell Line Gene Mutation Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-PK-A5H8-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08169 hippocampus HPA Tissue Protein Expression Profiles -1.0 -0.880199 PRDM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51435 interanterodorsal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10231 RNF31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.09561 SP in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05873 MTHFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11315 gastrointestinal tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.488667 GSE133213_6_v_13_znrf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null superficial stratum of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.48937 brain GTEx Tissue Gene Expression Profiles 1.0 0.917241 GTEX-POMQ-0326-SM-2I5FO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.843245 TRIM23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.36486 GSE217552_3_v_2_fisetin_human RummaGEO Drug Perturbation Signatures 1.0 null PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-DMOG_-_HIF1A-gene_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null r5 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16462 FLOT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.06219 ZCCHC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16834 Piriform area, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33832 outer portion of lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16822 PATL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67096 HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.894756 cerebellum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.322414 MSH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.25366 GTEX-R55E-0008-SM-48FCG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.97964 GTEX-UTHO-3026-SM-3GAFB GTEx Tissue Sample Gene Expression Profiles 1.0 1.75746 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DG-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Eggshell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.734 MDA-MB-231 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.892117 RPL28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68985 GSE138019_1_v_2_nudt12_mouse RummaGEO Gene Perturbation Signatures 1.0 null RSC1A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86179 Sox17 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.6871 ZBTB42 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23663 TBC1D24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55832 CTCF_astrocyte of the spinal cord_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SELENOT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72902 SEPTIN11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27424 KLKB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.21075 CMLT1 CCLE Cell Line Gene Expression Profiles 1.0 1.48327 GTEX-PLZ4-0008-SM-48TE6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5444 PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_result_of_MR_analysis_and_sensitivity_analysis_for_DLco_decline_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GLIPR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87384 ULBP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64885 mammillary body, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.987599 mantle zone of VPrP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07878 TC32 CCLE Cell Line Gene Expression Profiles 1.0 2.07515 neuroepithelial cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CEBPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71397 primary auditory cortex (core)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.39394 Lung adenocarcinoma_LUAD_TCGA-NJ-A55A-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100330_PCx_possible Alzheimer's disease_no TBI_100+_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.66511 GTEX-NPJ8-2626-SM-2D7W2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02801 caudal subdivision of medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.24598 GTEX-Q2AG-0005-SM-33HBX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.824958 cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040964 GTEX-WZTO-2826-SM-3NM8P GTEx Tissue Sample Gene Expression Profiles 1.0 1.51785 liver TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.251934 ASXL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13293 interstitial nucleus of Cajal, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.93921 Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WM-01A-12R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TLR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30346 caudal ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.03222 GTEX-X4XX-0126-SM-3NMC2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.887604 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null abducens nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.0037 anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.50742 ZNF112 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74484 lower (caudal) rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.67631 PTBP1_02_07 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.65208 BHLHE41 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.2798 p3 portion of parabrachial pigmented nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40537 brain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058399 CELF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35214 GSE225901_2_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-S7SE-0011-R11A-SM-2XCDD GTEx Tissue Sample Gene Expression Profiles 1.0 1.20782 ONDA9 DepMap CRISPR Gene Dependency 1.0 2.34169 ZNF330 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17699 HMEL CCLE Cell Line Gene Expression Profiles 1.0 1.74119 H3K27me3_megakaryocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MFM-223 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.74171 Brain Lower Grade Glioma_LGG_TCGA-HT-8558-01A-21R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null A-Vietnam-1203-2004(H5N1)_7Hour_None_GSE43204 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.57988 Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26245 Mesophyll TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.794 telencephalon TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE161864,GSE161866_0_v_2_ror2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-SIU7-0006-SM-2XCE6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.826261 EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE215086_1_v_7_batf_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55E-2526-SM-2TC6H GTEx Tissue Sample Gene Expression Profiles 1.0 1.41156 GTEX-T2YK-0005-SM-32QOV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16316 NREP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79479 Presubiculum, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.79551 fallopian tube HPA Tissue Gene Expression Profiles 1.0 1.27029 ETV2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25027 PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S1-Table_S1_Instrumental_variables_used_in_MR_analysis_of_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03957 vascular disease GWASdb SNP-Disease Associations 1.0 0.064516 CP in rostral hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09151 OUMS-23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.892117 biological_process GO Biological Process Annotations 2015 1.0 null Piriform area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21898 r9 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09642 GTEX-X261-3226-SM-3NMC3 GTEx Tissue Sample Gene Expression Profiles 1.0 2.66711 mediodorsal nucleus of thalamus_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.861969 GSE205540_2_v_3_phloridzin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Fetal Death CTD Gene-Disease Associations 1.0 1.44001 TP63 JASPAR Predicted Transcription Factor Targets 1.0 null TAF1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.354 TMBIM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95519 amygdaloid complex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.968517 facial motor nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.957985 GPC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80735 intermediate stratum of r10Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.75799 dorsolateral part of Lat Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2572 intermediate stratum of VPrP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36634 PITX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66928 TAL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22409 Supraoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22153 GSE129241_3_v_0_valproic acid_human RummaGEO Drug Perturbation Signatures -1.0 null RBMY1A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.091 GSE138019_4_v_6_nudt12_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCIH2052 CCLE Cell Line Gene Expression Profiles -1.0 -1.6674 KASUMI1 CCLE Cell Line Gene Expression Profiles -1.0 -1.46832 amygdaloid complex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.93448 Rectum adenocarcinoma_READ_TCGA-AF-6655-01A-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WHSE-3026-SM-3P5ZH GTEx Tissue Sample Gene Expression Profiles 1.0 0.872014 Perturb_9765_KO_Ikbkb/Shp2_SRP285005 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.79254 fallopiantube_8d HPA Tissue Sample Gene Expression Profiles 1.0 1.44272 ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC5550424-41467_2017_212_MOESM4_ESM.xlsx-Hematlas-Genesets-ZNF43_ZNF43 Rummagene Transcription Factor Associations 2026 1.0 null primary auditory cortex (core)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.13734 GTEX-XUYS-0326-SM-47JX2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05473 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AP-01A-12R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CAPRIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.06399 hsa-miR-1251 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 Sarcoma_SARC_TCGA-X6-A8C7-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RCC10RGB DepMap CRISPR Gene Dependency 1.0 4.40778 hsa-miR-3612 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 Interfascicular region TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.222 CIDEC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46264 GTEX-QDVJ-0008-SM-48U2E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.83109 FKBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61789 GSE189356_5_v_0_dexamethasone_mouse RummaGEO Drug Perturbation Signatures -1.0 null Internode region of axon COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.641 GTEX-OOBK-0126-SM-2YUND GTEx Tissue Sample Gene Expression Profiles 1.0 1.02666 NCI-H2009 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.949954 superficial stratum of PO2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.79443 RBBP5 ENCODE Transcription Factor Targets 1.0 null PFEIFFER Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18718 PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null GRIK5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49626 GCT COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-QMR6-1326-SM-32PLB GTEx Tissue Sample Gene Expression Profiles 1.0 1.35304 viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.303559 fat_a.V1 HPA Tissue Sample Gene Expression Profiles -1.0 -0.89193 Cellulose microfibril COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.694 HOXD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05563 ARHGEF15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90776 inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.967267 PCGF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.99894 GTEX-Q2AI-0008-SM-48U2H GTEx Tissue Sample Gene Expression Profiles -1.0 -2.14498 Esophagus - Mucosa GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.652571 MFSD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72117 SLITRK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73152 ZNF273 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.71292 parvocellular part of r8LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11173 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.59566 PMC5095001-oncotarget-07-36293-s002.xlsx-Table_S2-Table_S2_MYCN-correlated_genes_and_their_correlations_with_other_transcription_factors_MYCN Rummagene Transcription Factor Associations 2026 1.0 null KLRG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9212 GTEX-XOT4-0626-SM-4B66L GTEx Tissue Sample Gene Expression Profiles 1.0 1.04211 CSRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75291 mantle zone of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01745 SREBP2-21459322-LIVER-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.044419 MRPL27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95651 Kidney Chromophobe_KICH_TCGA-KL-8327-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QEG4-1226-SM-2S1P6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.861071 hippocampus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.9461 CTCF_fibroblast of upper leg skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC2218 CCLE Cell Line Gene CNV Profiles -1.0 -1.86577 r6 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57953 inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.30787 superior colliculus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.67527 HTRA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.507 PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_AA_NP-Unnamed_2_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WWYW-0011-R10A-SM-3NB35 GTEx Tissue Sample Gene Expression Profiles 1.0 0.84603 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EP-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VZ in rostral cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.19154 GTEX-T6MN-0011-R11A-SM-32QOX GTEx Tissue Sample Gene Expression Profiles 1.0 1.3067 cerebral cortex HPA Tissue Protein Expression Profiles -1.0 -0.880199 GTEX-XUJ4-0004-SM-4BOQE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.928362 HPBALL CCLE Cell Line Gene CNV Profiles 1.0 3.2803 OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.950173 SUPT4H1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94423 GTEX-S7PM-0008-SM-3NM9Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42017 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5VV-06A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC2157 CCLE Cell Line Gene Expression Profiles 1.0 1.35401 RASL11B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06532 CGTH-W-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null core part of the anterobasal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07932 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T2YK-0008-SM-4DM6M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58486 MKN74 DepMap CRISPR Gene Dependency 1.0 4.11933 mouth disease GWASdb SNP-Disease Associations 1.0 0.342574 CAL-148 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.01554 FZD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87516 blood GTEx Tissue Gene Expression Profiles -1.0 -1.87375 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FS-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-P4PP-0008-SM-48TDV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08256 GSE199204,GSE211619_4_v_3_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE92364_1_v_5_asparaginase_mouse RummaGEO Drug Perturbation Signatures 1.0 null LPP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70386 GSE205540_2_v_0_phloridzin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE108500_1_v_0_foxp1_human RummaGEO Gene Perturbation Signatures 1.0 null AGPAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.371 Perturb_5949_KD_PTBP1_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 8.8576 CTCF_fibroblast of villous mesenchyme_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NFK9-0006-SM-3GACS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.858136 GSE135030_11_v_2_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE136742,GSE136744_2_v_3_setd2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Epidermal lamellar body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.058 abnormality of the cardiovascular system GWASdb SNP-Phenotype Associations 1.0 0.040638 Dendritic spine neck COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.748 TMEM52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47065 anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.53812 gallbladder HPA Tissue Protein Expression Profiles 1.0 1.61219 GTEX-T8EM-1326-SM-3DB7G GTEx Tissue Sample Gene Expression Profiles 1.0 1.02731 inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.56576 membrane raft COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.191777 ZBTB21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40322 GSE202434,GSE202438_3_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null abnormality of head or neck GWASdb SNP-Phenotype Associations 1.0 0.122289 internal granular layer of CbVCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04547 MEWO COSMIC Cell Line Gene Mutation Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A3YL-01A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral mammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23261 Lung adenocarcinoma_LUAD_TCGA-55-8512-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BCLAF1_02_142 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 4.20945 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4338-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r6 part of posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32934 SLC35A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23597 Lung adenocarcinoma_LUAD_TCGA-55-6986-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE185519_4_v_5_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null inner CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.57973 hematopoietic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051256 H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MOLT-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE128730_4_v_1_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7325-01B-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GPR75 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65059 ST3GAL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72185 HCC4017 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.40003 GSE149035_1_v_5_hepacam_human RummaGEO Gene Perturbation Signatures 1.0 null GABRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88644 NCI-H1930 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23349 Liver Cirrhosis CTD Gene-Disease Associations 1.0 1.03159 SNU216 DepMap CRISPR Gene Dependency 1.0 8.62996 pancreas HPA Tissue Gene Expression Profiles -1.0 -0.944921 lateral ventricle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.151483 PAX5 ENCODE Transcription Factor Targets 1.0 null ENTPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4305 SYCP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13939 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M5-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_18148_KO_Ikbkb_SRP285005 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.04771 GSE163240_3_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null RUNX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29435 GTEX-XMD1-0011-R8A-SM-4AT48 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20732 GTEX-P4QT-0008-SM-48TDZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23252 CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4327-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null thyroid BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.876479 AP-2rep MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-WRHK-1426-SM-3MJF9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.96473 superficial stratum of InsCx (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03475 MED11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47356 DGCR6L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84243 YMB1 CCLE Cell Line Gene Expression Profiles 1.0 1.36796 GTEX-UTHO-3126-SM-3P5ZB GTEx Tissue Sample Gene Expression Profiles 1.0 2.53942 KYSE70 DepMap CRISPR Gene Dependency 1.0 2.30213 WHAMM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77615 MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09829 GTEX-SE5C-0006-SM-4BRW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.835021 GTEX-X4EP-0005-SM-3P5ZE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.89158 SU-DHL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.63312 FGF21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23691 GSE138841_0_v_1_trim6_human RummaGEO Gene Perturbation Signatures -1.0 null external granular (germinal) layer of upper rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.33098 ZNF136 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.065 SOX10 MotifMap Predicted Transcription Factor Targets 1.0 null MCM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05929 GTEX-X5EB-0426-SM-46MVY GTEx Tissue Sample Gene Expression Profiles 1.0 0.994388 PMC9894241-pnas.2211429119.sd05.xlsx-G6_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST Rummagene Transcription Factor Associations 2026 1.0 null Serous carcinoma_Fallopian tube_GSE10971 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.42441 epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CENPQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.50638 disease GWASdb SNP-Disease Associations 1.0 0.02846 Cob TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.609 GTEX-XQ8I-0426-SM-4BOPO GTEx Tissue Sample Gene Expression Profiles 1.0 0.940564 hsa-miR-4733-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.404082 PIGV CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55242 CTCF_fibroblast of the aortic adventitia_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNX11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76945 Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A8NY-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null fallopiantube_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.12099 FSP27_KO_GDS3768_514_mouse_White adipose tissue (WAT) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-RWSA-0726-SM-2XCBE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41423 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A57G-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral periolivary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06955 dorsolateral prefrontal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.29888 HDAC1 ENCODE Transcription Factor Targets 1.0 null FZD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58912 8305C DepMap CRISPR Gene Dependency 1.0 2.78905 PMC10568675-JCMM-27-3157-s003.docx-70-RFX3_RFX3 Rummagene Transcription Factor Associations 2026 1.0 null TMEM69 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57438 PPARA_KO_GDS3748_516_mouse_Livers GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NH-01A-12R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15326 Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HH-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LRRC58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94224 H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PAGE4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45006 GTEX-T2IS-0011-R11A-SM-32QPC GTEx Tissue Sample Gene Expression Profiles 1.0 0.887409 GSE186620_0_v_1_ascl1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-N7MT-1026-SM-3TW8T GTEx Tissue Sample Gene Expression Profiles 1.0 3.15988 RPSA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32493 HIPK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56382 KPNA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41441 SKP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44159 SELENOV CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8657 DXO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66661 orbital frontal cortex_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.86372 VIIIA, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.93019 retromammillary area, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.15285 CTCF_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6715699-41467_2019_11785_MOESM4_ESM.xlsx-CSL_KD-Genes_differentially_expressed_upon_CSL_silencing_AR Rummagene Transcription Factor Associations 2026 1.0 null MAFK ENCODE Transcription Factor Targets 1.0 null GTEX-SIU7-1126-SM-2XCDW GTEx Tissue Sample Gene Expression Profiles 1.0 1.14813 r7 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.68547 RARG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.3852 PPP4R3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26442 GTEX-U8T8-0005-SM-3DB8F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31125 GTEX-XXEK-1726-SM-4BRVB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.946066 GSE202434,GSE202438_8_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-T6MN-2726-SM-4DM77 GTEx Tissue Sample Gene Expression Profiles 1.0 1.39562 GTEX-V1D1-0008-SM-4JBIJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70608 GTEX-QMR6-0011-R5A-SM-32PKT GTEx Tissue Sample Gene Expression Profiles 1.0 0.853948 GTEX-SUCS-0002-SM-3NMAJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.84104 Lyf-1 MotifMap Predicted Transcription Factor Targets 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9R0-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U3ZM-1526-SM-3DB9D GTEx Tissue Sample Gene Expression Profiles 1.0 0.953582 GTEX-QLQW-0005-SM-2S1RA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.974257 neuroepithelium TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NCI-H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01678 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29G-06A-12R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null XPNPEP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79944 Ar JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.519 Hoxa13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.9899 ZDHHC17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9615 ZNF804B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01525 TFDP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77876 GSE182680,GSE182683_5_v_12_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-SN8G-1526-SM-4DM79 GTEx Tissue Sample Gene Expression Profiles 1.0 0.924513 GSE182680,GSE182683_0_v_12_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null KYSE-520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.64719 caudal ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.51468 496100549_FWM_no dementia_TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.78998 F8A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.9238 SETBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15779 EFE184 DepMap CRISPR Gene Dependency 1.0 3.34731 midbrain reticular formation, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.865786 EXOG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47601 CHD1 ENCODE Transcription Factor Targets 1.0 null GTEX-P4QS-0008-SM-48TDY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.968235 GSE214382,GSE214383_1_v_2_ascl1_human RummaGEO Gene Perturbation Signatures -1.0 null HSPB9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39826 GTEX-PWN1-0008-SM-48TEA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51559 GTEX-S95S-0008-SM-4AT5M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.901046 ADAMTS15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64832 FOS::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.0062 H3K4me2_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2925-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-3184 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 VZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.926452 PTMA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35542 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7915-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PTF1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55654 GSE184892_0_v_2_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null Supramammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.69712 PRXL2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5807 Fallopian Tube GTEx Tissue Gene Expression Profiles 2023 1.0 1.9469 GPX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59852 intermediate stratum of r6Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45757 MON2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74867 GSE229309,GSE229314_4_v_1_elavl1_human RummaGEO Gene Perturbation Signatures 1.0 null OVCAR433 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09829 ZBTB25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31552 GSE71468,GSE76476_0_v_1_rbfox1_human RummaGEO Gene Perturbation Signatures 1.0 null UBIAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95626 H3K27ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 496100405_TCx_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.15201 WSCD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88651 cerebrospinal fluid TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.308612 PPARG-20887899-3T3-L1 PREADIPOCYTE CELLS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null amygdaloid complex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.12478 Liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.169 KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11543 GTEX-R55G-0006-SM-2TC6O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6183 PRPSAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4474 SIRT5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73302 H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PTX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.49224 cellular_component GO Cellular Component Annotations 2015 1.0 null r3 roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61293 127399 DepMap CRISPR Gene Dependency 1.0 2.48638 duodenum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.315498 MYOC_OE_GDS1640_269_mouse_retina GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A815-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null embryonic stem no feeder BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.21384 GTEX-XMD1-0011-R1A-SM-4AT4C GTEx Tissue Sample Gene Expression Profiles 1.0 0.95752 triangular septal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55348 GSE182680,GSE182683_5_v_8_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null KIRREL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.95846 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80Q-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XOT4-0526-SM-4B66O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26905 Prostate adenocarcinoma_PRAD_TCGA-KK-A8I4-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-485-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 CPNE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50773 CTCF_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KL-8338-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_HSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null INKA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84452 GTEX-OHPL-0326-SM-33HC8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.868129 PPARG JASPAR Predicted Transcription Factor Targets 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5094-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-R55F-1226-SM-2TF59 GTEx Tissue Sample Gene Expression Profiles 1.0 1.34965 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZK-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-4422-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CREBZF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65516 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4828-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MTF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.8604 PMC12775252-18_2025_5991_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_2_Up-_and_down-regulated_genes_in_TCF7L2-depleted_EVT_compared_to_control_EVT_TCF7L2 Rummagene Transcription Factor Associations 2026 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NF-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ATAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44099 STMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32284 A3/KAW Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34969 FAM219B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77363 GTEX-WK11-2526-SM-3NM9Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16949 striatum_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.75146 GTEX-PLZ6-0008-SM-48TD5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.862591 PORCN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02534 PPP1R12C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11342 GTEX-U412-0426-SM-3DB9O GTEx Tissue Sample Gene Expression Profiles 1.0 1.48357 ZNF418 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.988 CREBL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5563 hippocampus (hippocampal formation)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.882147 cerebellar cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.940409 anterior group of nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08044 PDLIM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32466 organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041211 GSE65617_2_v_3_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-SIU7-1826-SM-2XCE2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21512 GSE220813_0_v_1_zfp750_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-539 TargetScan Predicted Conserved microRNA Targets 1.0 0.568687 QE-03-UA61_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.62214 GATA3 ENCODE Transcription Factor Targets 1.0 null EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.833868 IZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.908094 limbic system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null HDMYZ CCLE Cell Line Gene Expression Profiles -1.0 -1.57202 GTEX-OOBK-1626-SM-2HMKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40135 Protoxylem TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.841 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68G-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D9-A1JW-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-ZG-A8QW-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-V1-A8MU-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HMGB1P1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3059 CIDEC_KO_GDS3776_552_mouse_Brown and white adipose tissues GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.043 CHRNA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86186 GTEX-U3ZN-2326-SM-3DB7W GTEx Tissue Sample Gene Expression Profiles 1.0 1.59035 GSE193351_1_v_3_ruxolitinib_human RummaGEO Drug Perturbation Signatures -1.0 null UBALD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17344 GTEX-N7MS-0011-R11A-SM-2HMJS GTEx Tissue Sample Gene Expression Profiles 1.0 1.51227 GSE152937_6_v_5_slc16a13_mouse RummaGEO Gene Perturbation Signatures -1.0 null EB-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.58057 KMS20 DepMap CRISPR Gene Dependency 1.0 3.50661 VZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.915097 GTEX-P4PQ-0008-SM-48TDX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31596 Sarcoma_SARC_TCGA-DX-A7ER-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SH4 DepMap CRISPR Gene Dependency 1.0 2.06448 brain HPA Tissue Gene Expression Profiles 1.0 0.891442 PK-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03929 large intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.318407 SNU-719 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.949954 PIANP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17717 GTEX-POMQ-2126-SM-2S1OJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07845 ARID3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11085 DIS3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50492 SP in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04903 SNRPG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.3201 GSE143944_2_v_0_ribociclib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-UPIC-1626-SM-4IHKT GTEx Tissue Sample Gene Expression Profiles 1.0 0.896158 NCI-H1650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.861309 LIG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8098 GSE163240_2_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null pituitary GTEx Tissue Gene Expression Profiles 1.0 2.16351 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.895838 GTEX-X4EO-2926-SM-4E3JH GTEx Tissue Sample Gene Expression Profiles 1.0 0.962705 Perturb_9244_KD_ENL_SRP074134 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.43426 bonemarrow_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.28382 GSE140965_1_v_4_mybpc3_human RummaGEO Gene Perturbation Signatures -1.0 null OKAJIMA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03855 H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intermediate stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16224 CTV-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Agranular insular area, ventral part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.304 lateropallial prepiriform area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00608 CTCF_GM12865_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.61243 ZNF555 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.56455 CTCF_HepG2_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null YIF1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98854 GSE193351_1_v_9_ruxolitinib_human RummaGEO Drug Perturbation Signatures -1.0 null amygdaloid complex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.26618 GTEX-R55C-0008-SM-48FCF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0502 brain ventricle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.110817 CPOX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92287 r5 part of the cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08074 mediodorsal nucleus of thalamus_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.37779 GR-ST COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-WYJK-0126-SM-3NMAB GTEx Tissue Sample Gene Expression Profiles 1.0 1.07768 MAZ ENCODE Transcription Factor Targets 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A411-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XQ8I-0626-SM-4BOPT GTEx Tissue Sample Gene Expression Profiles 1.0 2.38295 ZNF354C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.875 PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1 Rummagene Transcription Factor Associations 2026 1.0 null A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_1day-MOI-10^3_None_GSE43302 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.99388 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-BI-A0VS-01A-11R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AARS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50495 CNDP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02148 ventrolateral prefrontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.959694 CTCF_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OUMS-23 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K9me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13471 CTCF_GM12865_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of r6Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04252 HEC1B DepMap CRISPR Gene Dependency 1.0 2.34803 RGL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78106 Prostate adenocarcinoma_PRAD_TCGA-HC-8259-01A-11R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OOBJ-0008-SM-3NB26 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.81036 ZNF324B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38162 MLXIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41687 MAFF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60559 NDUFS7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37688 GTEX-TKQ1-0006-SM-33HBI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04386 KRTCAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3673 GTEX-RWS6-0008-SM-47JYV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.874129 SP in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03584 Sarcoma_SARC_TCGA-DX-A7EM-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EP300 ENCODE Transcription Factor Targets 1.0 null bed nucleus of the external capsule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13075 hsa-miR-4468 TargetScan Predicted Conserved microRNA Targets 1.0 0.283838 WHSC1 ENCODE Transcription Factor Targets 1.0 null fh4 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.818 superficial stratum of isBI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06532 Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DI-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lysosomal acid lipase deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.151 ZNF384_02_203 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.61667 GTEX-U8XE-1526-SM-4E3HT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06966 Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CF-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PCDHB9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61382 Perturb_10857_KO_Shp_SRP220815 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.64316 MYNN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14695 GTEX-PW2O-0006-SM-2I3DV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2972 liminal reticular formation of m2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50069 Perturb_10788_KO_Shp_SRP220815 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.40655 NDUFS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38609 H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01678 Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4W-01A-12R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer 1 of PrS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43246 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81P-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HNRNPLL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21709 SIRT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90128 PELI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72011 GTEX-RN64-0008-SM-48FEZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.913352 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A465-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-4135-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null amygdaloid complex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.04213 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A550-01A-61R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051498 NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17561 FUBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87164 PMC10042887-41419_2023_5742_MOESM3_ESM.xlsx-Table_S3-Table_S3_Differently_expressed_genes_in_HOXB3_vs_HOXB3-_aPCA_HOXB3 Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A854-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF444 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28453 ARID5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77137 GTEX-NPJ8-1526-SM-2D7VU GTEx Tissue Sample Gene Expression Profiles 1.0 1.71607 GTEX-NL3G-0008-SM-4E3JX GTEx Tissue Sample Gene Expression Profiles -1.0 -2.20097 SKRC20 DepMap CRISPR Gene Dependency 1.0 4.50449 CAPN15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25308 Carboxylesterase type B, active site InterPro Predicted Protein Domain Annotations 1.0 null ZFYVE9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6671 GSE153867_6_v_3_olaparib_human RummaGEO Drug Perturbation Signatures 1.0 null Disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.095 CTCF_endothelial cell of umbilical vein_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-544b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 KMS-12-PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.70171 SPRED3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31735 PMC12179407-MCO2-6-e70261-s004.xlsx-down_TET3-KO_PQ_vs_Cas9_PQ-Unnamed_10_TET3 Rummagene Transcription Factor Associations 2026 1.0 null SLC35C2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00706 GTEX-WZTO-0011-R3B-SM-3NMC6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04296 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3436-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-62-A46S-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-3155 TargetScan Predicted Conserved microRNA Targets 1.0 0.181316 GSE158969_1_v_2_trastuzumab_human RummaGEO Drug Perturbation Signatures 1.0 null PDGFA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10115 PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S2-Table_S2_Full_result_of_MR_estimates_for_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null cerebral lobe TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE120612_7_v_5_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null Lysosomal storage disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.134 Artery - Coronary GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.659447 NCOA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4769 GSE166920_6_v_5_adalimumab_human RummaGEO Drug Perturbation Signatures 1.0 null SIT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01791 GTEX-RVPU-0005-SM-2TF6L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.891117 CZIB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46551 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.315 RHJT DepMap CRISPR Gene Dependency 1.0 2.44335 GTEX-NL4W-0006-SM-2I3GH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.73117 GTEX-X4EP-0626-SM-3P621 GTEx Tissue Sample Gene Expression Profiles 1.0 0.868803 MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PKP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85391 GTEX-RU72-0006-SM-2TF65 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.849584 CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellar cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.74178 DTX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6097 EMD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79507 hindbrain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.29996 Triangular nucleus of septum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4643 LAMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65455 Perturb_16478_OE_Klk6_SRP245408 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 496100514_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.09313 CTCF_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VPS33A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31214 Brain_Hippocampus_Middle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.86236 GSE185519_1_v_5_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-F_48h_1-Unnamed_0_PDX1 Rummagene Transcription Factor Associations 2026 1.0 null PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-female_port-FOS_FOS Rummagene Transcription Factor Associations 2026 1.0 null episupraoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.35304 VPS37A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35111 r10 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42856 SW 620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08128 SAP130 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74503 SELENOH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.0546 CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34969 ZNF761 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22225 PDE6D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85547 WM2664 CCLE Cell Line Gene Expression Profiles -1.0 -1.4617 GTEX-X62O-0008-SM-46MU5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.20736 SNX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11132 Granular lamina of the cochlear nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1325 SK-MM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.85225 superior olivary complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.843482 GTEX-R3RS-0008-SM-48FF1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10191 hsa-miR-4651 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Gene_Name_HNF4A Rummagene Transcription Factor Associations 2026 1.0 null PA-TU-8988T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11543 caudal ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.62906 polymorphic layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.89075 HS939T CCLE Cell Line Gene Expression Profiles -1.0 -2.00815 H3K27me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Sox7 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.7195 GSE182680,GSE182683_10_v_8_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05674 CTCF_fibroblast of pulmonary artery_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TXNDC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41144 Agranular insular area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23375 CTCF_GM12868_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR2F2_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7884-01B-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.21853 GTEX-RNOR-2326-SM-2TF4I GTEx Tissue Sample Gene Expression Profiles 1.0 1.22515 GTEX-P4PQ-0005-SM-2HMKJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3597 SIRT1_KO_GDS3666_295_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null abnormality of the face GWASdb SNP-Phenotype Associations 1.0 0.145045 RABGAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66804 dorsal thalamus_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03167 SPEG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74728 CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RFX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.1137 GTEX-QDVJ-1726-SM-2I5FX GTEx Tissue Sample Gene Expression Profiles 1.0 0.997112 Spinal root TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.678 GSE193402_0_v_2_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null Crus II, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01182 Prostate adenocarcinoma_PRAD_TCGA-J4-A83I-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null submammillothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.75823 SKMM2 CCLE Cell Line Gene CNV Profiles -1.0 -1.62212 GTEX-X585-0011-R10A-SM-46MUY GTEx Tissue Sample Gene Expression Profiles 1.0 0.991776 H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7SF-0008-SM-3NM8T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14951 duodenum HPA Tissue Protein Expression Profiles 1.0 1.61219 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5882-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PARK7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83236 GSE211128_9_v_0_angptl4_human RummaGEO Gene Perturbation Signatures 1.0 null IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.31849 Orbital area, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19867 MAX ENCODE Transcription Factor Targets 1.0 null posteroventral (inferior) parietal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.934996 Lung adenocarcinoma_LUAD_TCGA-55-A494-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_11298_KO_Bmal1_SRP060295 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -12.3066 H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QLQW-1326-SM-2S1QS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.67282 COLO320 DepMap CRISPR Gene Dependency 1.0 5.35121 SSU72 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8657 Perturb_11159_KO_Foxo1_SRP094428 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 11.2408 superficial stratum of r7Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.54011 XRCC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60602 subarachnoid space TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.298524 GM12878 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.64716 NCIH460 CCLE Cell Line Gene CNV Profiles 1.0 1.45474 B3GAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07339 GTEX-XUYS-0008-SM-47JYZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17443 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4833-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r8 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.76066 ETV5::FOXO1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.4341 GTEX-NL3H-0008-SM-4E3HU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35001 Myosin VIII complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.231 Phragmoplast COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.749 periaqueductal gray substance, ventral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08595 GTEX-VUSG-0008-SM-4KL24 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29179 GTEX-U3ZG-0006-SM-47JWX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62337 Perturb_11105_KO_Tsc1/Depdc5_SRP219943 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 DMS114 CCLE Cell Line Gene Expression Profiles 1.0 1.42379 G122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15729 STAT3_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12869_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCAN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04989 PMC9541747-AGE-53-680-s003.xlsx-TableS6-Table_S6_Genes_with_missense_mutations_in_Yaroslavl_cattle_MAF_0_1_and_FST_0_4_in_the_1000_Bull_Genomes_Run_9_MAF Rummagene Transcription Factor Associations 2026 1.0 null G112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.83479 Perturb_12208_Mut_TP53_SRP287851 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.11778 GTEX-X4XY-0326-SM-46MVZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.880853 membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041274 inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.891539 GTEX-QESD-0526-SM-2I5G5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.848108 GSE174418,GSE174421_2_v_3_mettl5_mouse RummaGEO Gene Perturbation Signatures 1.0 null CEP290 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03905 H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01745 Ventral tegmental area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02074 SYNE4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83122 CAL148 CCLE Cell Line Gene CNV Profiles -1.0 -2.01165 MYOD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73494 GTEX-P4PP-0126-SM-3LK69 GTEx Tissue Sample Gene Expression Profiles 1.0 0.893945 anterior olfactory area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01841 STAT3_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPA-23403033-LIVER-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null hsa-miR-583 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 Endopiriform nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05036 extracellular region part GO Cellular Component Annotations 2015 1.0 null ATP2C1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63439 GTEX-QXCU-0008-SM-48FCH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16413 fallopiantube_8b HPA Tissue Sample Gene Expression Profiles 1.0 0.913739 FBXO41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06516 MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T5JW-0008-SM-4DM5X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03479 amygdaloid complex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.4667 r6 part of trigeminal transition zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48527 NCIH838 CCLE Cell Line Gene CNV Profiles 1.0 1.64274 CEBPB_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CBX3 ENCODE Transcription Factor Targets 1.0 null H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletalmuscle_e HPA Tissue Sample Gene Expression Profiles -1.0 -2.85833 HSD3B7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27286 ZNF556 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08784 WM983B CCLE Cell Line Gene Expression Profiles -1.0 -1.55524 GTEX-XXEK-0005-SM-4BRWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28054 ZNF853 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.47111 CTCF_GM12874_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DIDO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77842 17660535-TableS4a GeneSigDB Published Gene Signatures 1.0 null organism form TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 skeletalmuscle_d HPA Tissue Sample Gene Expression Profiles -1.0 -0.864736 GNRH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79704 superficial stratum of THyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17774 bone marrow HPA Tissue Gene Expression Profiles -1.0 -1.09145 Uterine Carcinosarcoma_UCS_TCGA-N8-A4PI-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PWOO-0008-SM-48TDU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.87017 TOLEDO CCLE Cell Line Gene CNV Profiles -1.0 -2.00359 SOX15 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.8272 H3K27me3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POMC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34934 mantle zone of r5Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13075 GTEX-NPJ7-2926-SM-3MJGQ GTEx Tissue Sample Gene Expression Profiles 1.0 3.86297 OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.892117 GTEX-U412-0526-SM-3DB9I GTEx Tissue Sample Gene Expression Profiles -1.0 -1.8756 GTEX-U412-0326-SM-3DB9L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.875709 Lung adenocarcinoma_LUAD_TCGA-78-8640-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SYO1 DepMap CRISPR Gene Dependency 1.0 2.70018 928 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.949256 PMC5842026-mmc5.xlsx-HIC1_directTargets_48h-Gene_symbol_HIC1 Rummagene Transcription Factor Associations 2026 1.0 null C1QL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21239 KYO1 DepMap CRISPR Gene Dependency 1.0 2.00147 primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.898443 CEBPB ENCODE Transcription Factor Targets 1.0 null HDAC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61598 MYBL2 ENCODE Transcription Factor Targets 1.0 null superficial stratum of POH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.3522 ABHD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80006 GTEX-O5YV-0006-SM-2I5GX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.874683 CD1D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64559 Prdm4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.2422 PMC6433273-pone.0214296.s009.xlsx-Table_C-S3_Table_Differentially_expressed_mRNAs_in_human_primary_monocytes_after_6_hours_of_LPS_stimulation_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null HEP G2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08128 JURKAT COSMIC Cell Line Gene Mutation Profiles 1.0 null hsa-miR-650 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 POLR2A_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.950173 PFN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05981 BCL11A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.3915 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Adrenocortical carcinoma_ACC_TCGA-OR-A5LR-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mammillary part of PHyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.06922 HADH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36372 GSE210682_2_v_1_methadone_human RummaGEO Drug Perturbation Signatures -1.0 null NCIH2126 CCLE Cell Line Gene Expression Profiles 1.0 1.90849 CDC16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71863 r1 part of intermediate nucleus of the lateral lemniscus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.48442 Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MC-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU719 CCLE Cell Line Gene Expression Profiles -1.0 -1.51866 EEF1AKMT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73797 CTCF_HCT116_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ESR1-26153859-MCF-7-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null H3K4me1_Breast vHMEC Roadmap Epigenomics Histone Modification Site Profiles 1.0 null DNASE1L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56096 GTEX-RU1J-0226-SM-2TF5Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.874646 Prostate adenocarcinoma_PRAD_TCGA-KK-A6E1-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTNNB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84713 CTCF_astrocyte of the cerebellum_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PPM1D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22435 KANK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37854 GTEX-X4EP-0126-SM-3P5YV GTEx Tissue Sample Gene Expression Profiles 1.0 1.01908 TMEM50A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.14279 ZNF41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99376 hsa-miR-4269 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Nymph TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.609 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A115-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_8500_OE_RAS_SRP150620 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -8.58655 GSE152050,GSE152052_1_v_0_arid1a_mouse RummaGEO Gene Perturbation Signatures 1.0 null SEC62 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14138 GSE102870_3_v_9_nr1h4_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_foreskin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VUSG-2326-SM-4KL1U GTEx Tissue Sample Gene Expression Profiles 1.0 0.910418 Uvula (IX) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51993 HYCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.49202 SLC30A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10886 HMBS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10596 COMMD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11808 STX1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00829 SNAI3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.6298 CALD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51855 EMG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04393 NCI-H1048 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.97042 GTEX-RU72-0011-R11A-SM-2TF6J GTEx Tissue Sample Gene Expression Profiles 1.0 0.984553 GTEX-RNOR-0526-SM-2TF4O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.94106 SPTBN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20678 GTEx Ovary 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures 1.0 4.70332 delayed eruption of teeth GWASdb SNP-Phenotype Associations 1.0 0.412794 Adrenocortical carcinoma_ACC_TCGA-OR-A5JF-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFE2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.3792 integument TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-A492-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEBPA-23403033-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE240027,GSE240030_5_v_4_atrx_mouse RummaGEO Gene Perturbation Signatures -1.0 null mediodorsal nucleus of thalamus_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.16454 Nuclear receptors meta pathway WikiPathways Pathways 2024 1.0 null ZNF280A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5061 r10 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44371 NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23257 GTEX-V1D1-0003-SM-3NMDP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.967385 bone marrow HPA Tissue Protein Expression Profiles -1.0 -1.61372 hippocampus (hippocampal formation)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.19726 Uvula (IX), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47214 GSE215086_5_v_7_batf_human RummaGEO Gene Perturbation Signatures -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-98-A53H-01A-12R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_8654_KO_ESRRA/ESRRG_SRP304242 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 Brain Lower Grade Glioma_LGG_TCGA-DU-A6S2-01A-21R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BAG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92527 SEL1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29064 VPS13A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53843 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FM-8000-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70785 SUPHD1 CCLE Cell Line Gene Expression Profiles 1.0 2.59507 E2F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.6994 GTEX-Q2AG-0008-SM-48U2K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.67366 GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null Perturb_16479_OE_Klk6_SRP245408 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 VZ in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.216 mediodorsal nucleus of thalamus_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.943541 BCL9L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.66214 Nucleus of the lateral olfactory tract, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.058 CTCF_fibroblast of villous mesenchyme_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.14808 pancreas HPA Tissue Protein Expression Profiles 1.0 0.872572 Atf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.502 COPS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15546 CTCF_GM12872_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB3L4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.5021 ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null GSE242199_9_v_3_ntrk2_human RummaGEO Gene Perturbation Signatures -1.0 null colorectum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.295297 ventrolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.98607 germ layer TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MYC_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158975_0_v_1_spp1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE235550_2_v_0_hspa9_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_mammary epithelial cell_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null DICER1_Deficiency_GDS3685_518_mouse_Hepatocytes GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-WL46-0011-R11A-SM-3MJFT GTEx Tissue Sample Gene Expression Profiles 1.0 1.38371 ZNF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7203 SMC3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1319 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.83479 nucleus of the central acoustic tract Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.78927 layer VI of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.6192 LI7 CCLE Cell Line Gene Expression Profiles -1.0 -1.74776 CTCF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFKBIB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.80646 MEIOC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52313 SNU1079 DepMap CRISPR Gene Dependency 1.0 4.01317 UBAC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75721 SKBR3 CCLE Cell Line Gene CNV Profiles -1.0 -2.00502 GSE193351_4_v_2_ruxolitinib_human RummaGEO Drug Perturbation Signatures -1.0 null pancreas BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.947508 r8 part of spinal trigeminal nucleus, interpolar part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23761 GTEX-WHSE-0011-R11A-SM-3P5YY GTEx Tissue Sample Gene Expression Profiles 1.0 0.973462 ACHN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.887516 Lung adenocarcinoma_LUAD_TCGA-86-A456-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STARD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29109 FOXA2 ENCODE Transcription Factor Targets 1.0 null SK-MES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39839 SNU201 CCLE Cell Line Gene Expression Profiles -1.0 -1.58217 RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MMP17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1942 RHOG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83925 GTEX-QDVN-1626-SM-48TZC GTEx Tissue Sample Gene Expression Profiles 1.0 1.76126 skin HPA Tissue Gene Expression Profiles 1.0 1.89197 HCC1263 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.43918 BHLHA9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53005 orbital frontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.76235 GTEX-QEG4-0008-SM-48TYZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90379 GPR37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40885 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EH-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TARDBP_02_169 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.32193 hsa-miR-3918 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 NPTXR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2339 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7X8-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WOFL-0006-SM-3TW8K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40356 GSE133070_2_v_4_prss1_mouse RummaGEO Gene Perturbation Signatures 1.0 null MAX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.6726 GTEX-T5JC-0426-SM-32PLO GTEx Tissue Sample Gene Expression Profiles 1.0 0.998338 496100495_FWM_no dementia_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.03479 CNIH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79693 GSE151612_4_v_7_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FR-A7UA-06A-32R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A46F-01A-31R-A250-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE157777_2_v_3_foxa3_mouse RummaGEO Gene Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-V1-A8MG-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U8XE-0226-SM-4E3J3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.886459 primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.887179 Lung squamous cell carcinoma_LUSC_TCGA-37-4129-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GGH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91359 Crus II, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.835132 HCT-15 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-O5YW-0008-SM-4E3IE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15873 MAFK JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.1309 fh5 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.039 FKBP14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95318 GSE182680,GSE182683_10_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null periventricular stratum of r2BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19641 CTSH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.51483 GSE239844_6_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.25086 FOXF2 JASPAR Predicted Transcription Factor Targets 1.0 null GSE156033_1_v_2_sparc_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-RVPU-0011-R10A-SM-2XCAH GTEx Tissue Sample Gene Expression Profiles 1.0 1.00121 anterior pretectal nucleus, ventral superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.09814 GTEX-WVLH-3126-SM-3MJGA GTEx Tissue Sample Gene Expression Profiles 1.0 1.19432 GTEX-PSDG-0226-SM-33HC1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00292 Rectum adenocarcinoma_READ_TCGA-G5-6235-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.20427 GSE130437_0_v_1_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null ACAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71111 USF2 ENCODE Transcription Factor Targets 1.0 null PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-fromNode_SOX4 Rummagene Transcription Factor Associations 2026 1.0 null microcellular tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24325 internal female genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE119978,GSE180930_6_v_7_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null NR2F2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88045 STOML2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67499 hypoglossal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02208 SRF JASPAR Predicted Transcription Factor Targets 1.0 null Bed nuclei of the stria terminalis, anterior division, dorsomedial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15768 FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WEY5-0001-SM-3P61Z GTEx Tissue Sample Gene Expression Profiles -1.0 -0.896991 LU165 DepMap CRISPR Gene Dependency 1.0 3.09058 PPARG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83096 GTEX-WHSB-1626-SM-3LK6J GTEx Tissue Sample Gene Expression Profiles 1.0 0.896162 HINT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80654 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10U-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE77108_5_v_9_saha_human RummaGEO Drug Perturbation Signatures 1.0 null ABRACL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32966 MAFK_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE182680,GSE182683_0_v_8_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-ensembl_AR Rummagene Transcription Factor Associations 2026 1.0 null female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-TML8-0005-SM-32QPA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.932029 cingulum bundle, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.26329 orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.47043 LS1034 DepMap CRISPR Gene Dependency 1.0 11.751 Ciliated epithelial cell_Esophagus_Human CellMarker Gene-Cell Type Associations 1.0 null GTEX-O5YU-0008-SM-4E3I7 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.56812 TRAPPC6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37116 NKX3-2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25469 VZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.851474 PMC9882185-media-2.xlsx-All_B2-AR_targets-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-TMMY-0226-SM-33HBA GTEx Tissue Sample Gene Expression Profiles 1.0 1.06878 496100653_PCx_probable Alzheimer's disease_no TBI_82_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.12564 H1_Cell_Line Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.952285 ventrolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04658 GTL-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.962204 GTEX-QMR6-1426-SM-32PLA GTEx Tissue Sample Gene Expression Profiles 1.0 1.34191 Prostate adenocarcinoma_PRAD_TCGA-VN-A88M-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QVUS-2826-SM-3GADB GTEx Tissue Sample Gene Expression Profiles 1.0 1.31765 GTEX-O5YT-0008-SM-4E3IQ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.44075 SKMES1 CCLE Cell Line Gene CNV Profiles 1.0 1.36559 EHD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21695 H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Anterior olfactory nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.58171 Lung squamous cell carcinoma_LUSC_TCGA-56-8309-11A-01R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-TSE9-0526-SM-3DB7Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.849069 Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47Y-01A-11R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FAM136A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19352 intermediate stratum of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52029 CTCF_GM12874_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6715699-41467_2019_11785_MOESM4_ESM.xlsx-CSL_KD-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OHPK-0008-SM-4E3JL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14386 mammillary part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0408 GTEX-UPIC-0002-SM-3NMDC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37868 PIK3CD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24736 H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null principal sensory nucleus of trigeminal nerve, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.984065 amygdaloid complex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.898143 Hepatomegaly CTD Gene-Disease Associations 1.0 1.20816 TGFBR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91576 GSE183606_1_v_0_rutaecarpine_human RummaGEO Drug Perturbation Signatures 1.0 null SW620 CCLE Cell Line Gene CNV Profiles 1.0 1.99291 PPRC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65122 GSE175787_5_v_9_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null nucleus of the inferior collicular brachium, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47411 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null nucleus incertus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00906 SEM DepMap CRISPR Gene Dependency 1.0 2.91883 Pancreas Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.27399 Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE182680,GSE182683_10_v_12_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null CHP-212 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.70687 PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Ensembl_ID_AR Rummagene Transcription Factor Associations 2026 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11D-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-N7MS-2526-SM-2D7W3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.39661 GTEX-R55E-2726-SM-48FCX GTEx Tissue Sample Gene Expression Profiles 1.0 1.47019 embryonic stem feeder layer BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.84957 GTEX-T5JC-2326-SM-32PMR GTEx Tissue Sample Gene Expression Profiles 1.0 1.92108 GSE214212_2_v_1_chd6_human RummaGEO Gene Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-97-A4M7-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.25208 MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF222 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36253 VZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.56613 GTEX-QMR6-0011-R1A-SM-32PKW GTEx Tissue Sample Gene Expression Profiles 1.0 0.872086 PPARG ChEA Transcription Factor Targets 1.0 null hydrolase activity, acting on ester bonds GO Molecular Function Annotations 2015 1.0 null GTEX-RNOR-1426-SM-48FDJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.877717 GSE184892_7_v_2_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null smallintestine BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.46784 GSE104508_0_v_3_dnmt3a_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF136 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32902 Sarcoma_SARC_TCGA-DX-A7EU-01A-22R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NF-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_11297_KO_Dicer_SRP041679 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -17.1379 496100277_FWM_no dementia_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.88856 HCC2814 CCLE Cell Line Gene Expression Profiles 1.0 1.63913 ARPC1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42862 GSE150072,GSE169209_4_v_11_qser1_human RummaGEO Gene Perturbation Signatures 1.0 null VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.55243 GTEX-XOT4-0008-SM-4B664 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28539 Schwartz-Jampel syndrome 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.354 inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.13379 GTEX-P44H-0011-R1A-SM-3NM8J GTEx Tissue Sample Gene Expression Profiles 1.0 0.944498 ATXN7L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44808 primary auditory cortex (core)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.22375 FAM221A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7878 emboliform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.3776 H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4844-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.13375 BBX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43136 GTEX-XQ8I-0006-SM-4BOQ5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.18356 r4 part of parvocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14099 neuroepithelioma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K27me3_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventral endopiriform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36339 ARPP19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.30207 CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KYSE-450 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.88323 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Y-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-91-A4BD-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GK-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null striatum_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.00702 GTEX-XBEW-0126-SM-4AT66 GTEx Tissue Sample Gene Expression Profiles 1.0 0.830958 Brain Lower Grade Glioma_LGG_TCGA-FG-A87Q-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null NDUFV3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85668 abnormality of the mouth GWASdb SNP-Phenotype Associations 1.0 0.186194 GSE211215_1_v_0_pemetrexed_human RummaGEO Drug Perturbation Signatures 1.0 null superficial stratum of r7BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.89071 CAKI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.895838 SELENOM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54223 membrane region COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.069538 TMEM14B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77881 MT2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34936 CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE162276_2_v_0_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF266 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70568 MORC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.34197 SRSF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4571 CTCF_HCT116_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-MEL-28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.86174 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null GSE171292_1_v_0_ehhadh_mouse RummaGEO Gene Perturbation Signatures -1.0 null PCGF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87188 r7 part of ventral parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33241 RAB4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60698 USP32 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69597 CTCF_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12871_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of r8Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.76066 GTEX-OIZH-0005-SM-2HMJN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52921 Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_46_OE_ERG/MYC_SRP069177 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.44317 KRIT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06462 GTEX-P4QR-0006-SM-2I5GN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.969546 endometrium_5a HPA Tissue Sample Gene Expression Profiles -1.0 -0.957624 deep layers of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1387 PMC9530161-41419_2022_5296_MOESM2_ESM.xlsx-Tab10_KDM5C-KD-up-DKD-rescued-Table_10_Up-regulated_genes_in_KDM5C-KD_and_rescued_genes_in_DKD_AR Rummagene Transcription Factor Associations 2026 1.0 null CUL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51862 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A4ZB-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SN8G-0126-SM-32PLI GTEx Tissue Sample Gene Expression Profiles 1.0 0.928434 GTEX-NPJ7-0008-SM-4E3JS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06126 Stat5a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.0124 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-V1D1-2026-SM-3GAF4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.43204 GSE125007,GSE125008_1_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null superficial stratum of PHyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29262 GA10 CCLE Cell Line Gene CNV Profiles 1.0 1.68077 GSE140997_4_v_7_nsun6_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WL46-2826-SM-3LK81 GTEx Tissue Sample Gene Expression Profiles 1.0 1.48241 Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 34.2243 WDR86 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87302 Nucleus of the solitary tract, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05339 HLCS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92098 CTCF_cardiac muscle cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MN-2626-SM-32PMQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.60062 GTEX-XUJ4-0005-SM-4BOQ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08727 ASCL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49338 ZSWIM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41537 PMC6491424-41598_2019_Article_43248.nxml--PCN_LPS_vs_CO_LPS_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null inner CP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04085 H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE149035_3_v_5_hepacam_human RummaGEO Gene Perturbation Signatures 1.0 null GSE132369,GSE132371_3_v_0_cccp_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null stomach HPA Tissue Protein Expression Profiles 1.0 1.61219 GTEX-XUW1-0826-SM-4BOP6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.24564 SP in rostral midinferior temporal cortex (area 36) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05462 CTCF_GM12873_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100494_HIP_no dementia_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.13795 PDE6G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08147 GTEX-QVUS-2926-SM-3GIJB GTEx Tissue Sample Gene Expression Profiles 1.0 1.4845 ARFGAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1525 GTEX-R55D-0826-SM-48FEA GTEx Tissue Sample Gene Expression Profiles 1.0 2.15182 YBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23027 abnormality of the teeth GWASdb SNP-Phenotype Associations 1.0 0.222566 IX, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.86741 PDE7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91809 Prostate adenocarcinoma_PRAD_TCGA-KK-A8I5-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE217552_3_v_0_fisetin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WFJO-0008-SM-4LVN7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.87835 PMC12478325-12672_2025_3468_MOESM1_ESM.xlsx-Table_S9-Table_S9_Results_of_MR_analysis_between_druggable_genes_eQTLs_and_CrNEN_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_fibroblast of mammary gland_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.962204 GTEX-PWCY-1926-SM-3NB25 GTEx Tissue Sample Gene Expression Profiles 1.0 0.967664 PARP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.48531 PPP2R5E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06543 GSE169155_3_v_7_acetaminophen_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE157777_1_v_0_foxa3_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF85 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.5976 SUDHL1 CCLE Cell Line Gene CNV Profiles 1.0 1.62789 outer CP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.06754 GTEX-XMD1-0006-SM-4AT4Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04416 substantia nigra reticulata, m1 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33373 GTEX-XUZC-1726-SM-4BRWS GTEx Tissue Sample Gene Expression Profiles 1.0 1.34558 GSE157594_6_v_4_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE193258,GSE193259_9_v_6_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null Piriform area, polymorph layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44033 CAMTA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47344 TCF12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.9784 UBR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81305 CGTHW1 CCLE Cell Line Gene Expression Profiles -1.0 -1.81529 lateral ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.941769 mantle zone of r7Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42856 hypertension GWASdb SNP-Disease Associations 1.0 0.521603 BOLA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19253 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H4-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11933697-41467_2025_58216_MOESM8_ESM.xlsx-SD6_ATF3_EV_NS1-SYMBOL_ATF3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QLQ7-1626-SM-2S1R8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.900183 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70T-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB7B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06517 WASF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.60941 PAX5_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RM2N-1426-SM-2TF4H GTEx Tissue Sample Gene Expression Profiles 1.0 0.880581 Hemoglobin levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.830103 SNU626 DepMap CRISPR Gene Dependency 1.0 2.78656 HNF4G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43707 GTEX-S7SF-0001-SM-3K2BE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.97786 Gustatory areas, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5063 SAV1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1199 HES7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.9422 GTEX-NL4W-0008-SM-4E3I2 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.00636 superior rostral gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.08947 GTEX-P4QS-1126-SM-3NMD5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.826117 ZNF704 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09562 cerebellar cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.888836 HCaRG_OE_GDS1411_72_human_HEK293 embryonal kidney cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE119978,GSE180930_6_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-OHPM-0008-SM-4E3IP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58066 Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A71R-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Flower stalk TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.803 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A23L-01A-11R-A16R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.4165 Gastric cecum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.54 interstitial nucleus of Cajal, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.37641 VIIIA, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.829118 Good syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.139 LGE-VZ border region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.09623 PUM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73456 Ebf2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.8245 GTEX-P4PQ-1626-SM-2HMKK GTEx Tissue Sample Gene Expression Profiles 1.0 0.900294 CFAP126 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90657 striatum_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.83243 Basolateral amygdalar nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15401 NAT14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91323 TEX41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95245 vestibular nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.831628 gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.177029 pioglitazone_homo sapiens_gpl570_gds4132 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null LB1047-RCC COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-VJYA-1126-SM-3GIJU GTEx Tissue Sample Gene Expression Profiles 1.0 0.825077 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51H-06A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.65338 GSE215086_0_v_1_batf_human RummaGEO Gene Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YL-A8SO-01B-31R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE114258_3_v_2_foxk1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A713-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052568 dexamethasone_homo sapiens_gpl4133_gse42619 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null STEAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10875 GTEX-XV7Q-0008-SM-4BRWL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32797 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5465-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCF4 ChEA Transcription Factor Targets 1.0 null SPATC1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44618 PHETA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89823 substantia nigra reticulata, isthmic part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06669 MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pyramus (VIII), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.51619 GTEX-RN64-0326-SM-2TC5J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02042 Premature aging_Skin fibroblast_GSE10123 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.34464 Perturb_9239_KD|OE_ENL|ENL_SRP074134 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.23605 GTEX-PLZ5-0006-SM-2S1NZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05245 ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.411321 intermediate stratum of LPrP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51018 lateral terminal nucleus of the accessory optic tract, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.84767 golgi apparatus LOCATE Predicted Protein Localization Annotations 1.0 null ESR1 JASPAR Predicted Transcription Factor Targets 1.0 null EPHX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14487 GSE202434,GSE202438_8_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null rostral (anterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.20911 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039404 GTEX-Q2AH-1626-SM-3GAF8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.19891 GTEX-POYW-0008-SM-48TE4 GTEx Tissue Sample Gene Expression Profiles -1.0 -3.1338 Fetal_Brain_Female Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.943617 GTEX-QEG5-0626-SM-2S1PP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62883 C11orf71 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18014 GTEX-X585-3026-SM-46MWF GTEx Tissue Sample Gene Expression Profiles 1.0 1.39032 VZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.57168 NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.43918 TIA1_KO_GSE54418_262_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null TFAP2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79426 reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-XLM4-0011-R8A-SM-4AT44 GTEx Tissue Sample Gene Expression Profiles 1.0 1.18769 anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.12457 Uterine Carcinosarcoma_UCS_TCGA-N6-A4VD-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null embryo TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NHLRC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46728 KCNE5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28613 20035825-TableS7a GeneSigDB Published Gene Signatures 1.0 null MYF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.3429 JURKAT CCLE Cell Line Gene Expression Profiles -1.0 -1.48714 Forebrain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 subbrachial nucleus, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29699 PPP2R5C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.08814 FOS ENCODE Transcription Factor Targets 1.0 null KAT2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67541 orbital frontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.873211 Cortical microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.525 ES-I3 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 0.988853 DMC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51666 FUS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56861 GSE182680,GSE182683_10_v_13_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null CENPW CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82464 GTEX-XMD1-0011-R3B-SM-4AT5R GTEx Tissue Sample Gene Expression Profiles 1.0 0.89405 KCNF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59989 GTEX-VJYA-0626-SM-4KL1S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01174 Prostate adenocarcinoma_PRAD_TCGA-HC-7740-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-8350-01A-11R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A6WI-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null corpus callosum Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.902192 DNAJC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13568 ZNF384 ENCODE Transcription Factor Targets 1.0 null EXO5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1864 GTEX-XQ3S-0001-SM-4B64K GTEx Tissue Sample Gene Expression Profiles -1.0 -2.26251 MEIOSIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.97133 hippocampus (hippocampal formation)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.978868 Perturb_5511_KO_Vdr/Med1_SRP282245 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.61542 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TOP2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35777 CW-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-N7MS-2625-SM-3LK77 GTEx Tissue Sample Gene Expression Profiles 1.0 1.45588 CREB3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.5382 GTEX-Q2AG-3026-SM-48U1L GTEx Tissue Sample Gene Expression Profiles 1.0 2.01436 MAK16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52089 HIF3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09506 brain stem TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.248683 subgranular zone of rostral dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.17393 primary visual cortex (striate cortex, area V1/17)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.947179 GTEX-Q2AG-0126-SM-33HBV GTEx Tissue Sample Gene Expression Profiles 1.0 0.952189 PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-Normal_309_TCF7_rep1_sorted_pea-Gene_Name_TCF7 Rummagene Transcription Factor Associations 2026 1.0 null VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04269 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052851 GTEX-RUSQ-1026-SM-2TF6V GTEx Tissue Sample Gene Expression Profiles 1.0 0.860785 SEC24B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76127 GSE203308_14_v_0_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4355-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM12873_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-T5JC-0011-R11A-SM-32PMB GTEx Tissue Sample Gene Expression Profiles 1.0 1.66241 Brain Lower Grade Glioma_LGG_TCGA-HT-A4DV-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09829 colorectal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.322273 PXMP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14397 GSE169155_6_v_4_acetaminophen_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE219195_1_v_3_rbm12_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_BE2C_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE175787_4_v_2_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null HCC1576 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-6147-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-A5B5-01A-21R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null USF2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE140441_2_v_0_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null IRGQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5634 CSF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01652 SK-BR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10452 ECD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5192 GSE56235_1_v_0_prdm11_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-T6MN-0002-SM-3NMAH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37062 HT-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.196 Nucleus of the brachium of the inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06995 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5876-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null striatum_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.847252 Pancreatic_Islets Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.02434 MXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.5677 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IL-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_foreskin fibroblast_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAKI2 DepMap CRISPR Gene Dependency 1.0 2.09246 Perturb_4823_KD_Chd4_SRP315519 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.63806 Ventricular hypertrophy_Myocardial tissue_GSE4678 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.29002 COPG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98271 GTEX-SIU8-0008-SM-4BRUC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08938 PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-F_48h_2-down-regulated_PDX1 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_keratinocyte_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8435-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE184892_7_v_3_trehalose_human RummaGEO Drug Perturbation Signatures -1.0 null ERCC6L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24832 Acquired metabolic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.031 BMAL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31224 PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S5-Table_S5_The_result_of_MR_analysis_and_sensitivity_analysis_for_FVC_decline_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-RVPV-0008-SM-47JYW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4125 Prostate adenocarcinoma_PRAD_TCGA-VP-A87J-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11933697-41467_2025_58216_MOESM9_ESM.xlsx-SD7_C_R_NS1_Med_ATF3_DEG-symbol_ATF3 Rummagene Transcription Factor Associations 2026 1.0 null SETD1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39484 GSE166004_5_v_4_pld1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_GM12871_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mediodorsal nucleus of thalamus_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.91606 BTBD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80087 RAPGEF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77738 GTEX-UTHO-0011-R11A-SM-3GIJE GTEx Tissue Sample Gene Expression Profiles 1.0 0.900478 GTEX-R3RS-0126-SM-3GIJL GTEx Tissue Sample Gene Expression Profiles 1.0 1.41509 Primary somatosensory area, upper limb, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66862 RAD23B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77434 GSE125007,GSE125008_4_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Sox5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.5645 blood TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null IMPDH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45435 SP in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20279 ZNF316 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23651 Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-8537-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE141143_1_v_0_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null SRSF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.21403 preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.82061 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-11A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hydrolase activity GO Molecular Function Annotations 2015 1.0 null RPMI 8226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39839 FNDC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.40688 intermediate stratum of r8Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.12714 GSE185519_3_v_5_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null SLC8A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5781 GTEX-POMQ-1926-SM-3NB1Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02066 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-T6MO-0006-SM-32QOU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90007 cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null posteroventral (inferior) parietal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.00989 H3K4me1_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null G141 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.29633 ERCC6L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68397 PMC9882185-media-4.xlsx-Neuron_KD-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-500-EBF3_EBF3 Rummagene Transcription Factor Associations 2026 1.0 null Gustatory areas, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29845 GTEX-NL3H-0006-SM-2I3FW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43601 PSPH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.88854 outer SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06603 CTCF_MCF-7_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null A375 COSMIC Cell Line Gene Mutation Profiles 1.0 null SNU685 DepMap CRISPR Gene Dependency 1.0 2.0023 GTEX-WVLH-0011-R11A-SM-3MJFO GTEx Tissue Sample Gene Expression Profiles 1.0 1.24314 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70R-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of RMa Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.06922 embryonic structure TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D9-A148-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QDT8-3026-SM-32PKB GTEx Tissue Sample Gene Expression Profiles 1.0 1.74162 Mammillary body Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26688 Declive (VI), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22755 GTEX-WRHU-0826-SM-3MJFN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08867 GSE178227_1_v_2_tet1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Crus I, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19194 Xylem parenchyma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.825 NCIH1385 CCLE Cell Line Gene Expression Profiles 1.0 1.56885 primary motor cortex (area M1, area 4)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.874859 mediodorsal nucleus of thalamus_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.05443 CTCF ENCODE Transcription Factor Targets 1.0 null Msgn1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.7989 GSE189789_0_v_1_oridonin_human RummaGEO Drug Perturbation Signatures 1.0 null MYOG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97042 CTCF_GM12867_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ectoderm TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null layer 1 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05138 GTEX-XOTO-2926-SM-4B65G GTEx Tissue Sample Gene Expression Profiles 1.0 1.32411 GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.39923 nucleus sagulum, superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36198 PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null layer VI of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.834694 GSE193402_0_v_3_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_foreskin fibroblast_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TFEB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49438 UBN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66564 GTEX-PLZ6-0006-SM-33HBZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11694 CDC25C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19913 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MECR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30218 cuneate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.900204 SNU-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30706 NCIH1650 CCLE Cell Line Gene CNV Profiles 1.0 2.03888 SG in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.36669 CHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43074 GTEX-RVPV-0011-R11A-SM-2TF6F GTEx Tissue Sample Gene Expression Profiles 1.0 1.29343 Obstructive sleep apnea_Hepatic Tissue_GSE1873 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.67194 R3HCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27833 NCI-H1437 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.40003 hsa-miR-2355-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 APOBEC3H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.99672 Lung squamous cell carcinoma_LUSC_TCGA-63-A5MW-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-3185 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 HUES64_Cell_Line Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.06842 mediodorsal nucleus of thalamus_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.868738 GSE160373_8_v_7_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null SOCS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8597 Heart Defects, Congenital CTD Gene-Disease Associations 1.0 1.35069 GTEX-PSDG-0008-SM-48TE5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.19738 GTEX-WL46-0011-R9A-SM-3MJFP GTEx Tissue Sample Gene Expression Profiles 1.0 0.864503 AKAP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7566 CTCF_GM12864_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ALMS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21399 GSE77108_3_v_9_saha_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-QVJO-1626-SM-2S1QW GTEx Tissue Sample Gene Expression Profiles 1.0 0.845686 Prostate adenocarcinoma_PRAD_TCGA-J9-A8CP-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE217982,GSE217983_2_v_3_hgfac_mouse RummaGEO Gene Perturbation Signatures -1.0 null DDX46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14252 r9 part of trigeminal transition zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.80161 blood TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051473 PMC5577301-in-17-237-s001.xls-AR_downregulated_DEGs-Kidney_GSE9493_GENE_AR Rummagene Transcription Factor Associations 2026 1.0 null Supramammillary nucleus, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66103 GSE182680,GSE182683_0_v_13_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null KLHL26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.50175 GTEX-PWCY-0008-SM-48TE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.868001 Hepatobiliary disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.157 NIBAN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.92702 gastrointestinal system disease GWASdb SNP-Disease Associations 1.0 0.106094 GTEX-N7MS-0008-SM-4E3JI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41509 CESS cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.337 mediodorsal nucleus of thalamus_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.23744 GTEX-U412-0006-SM-3DB8J GTEx Tissue Sample Gene Expression Profiles -1.0 -0.998445 LCOR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77563 medial ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.06559 primary motor cortex (area M1, area 4)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.33126 VZ in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.900278 VMRCLCD DepMap CRISPR Gene Dependency 1.0 2.98627 GTEX-WWYW-3026-SM-3NB36 GTEx Tissue Sample Gene Expression Profiles 1.0 1.29214 suboptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13581 OC315 CCLE Cell Line Gene Expression Profiles -1.0 -1.72609 Liver angiosarcoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.08 HT1197 DepMap CRISPR Gene Dependency 1.0 2.28443 THBS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17429 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YM-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FAM200C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0341 GTEX-OXRK-0008-SM-3NB28 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12539 SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.5569 Lung squamous cell carcinoma_LUSC_TCGA-56-A4BY-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null trochlear nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.90912 PMC6713698-109_2019_1809_MOESM2_ESM.xlsx-AR-PCOS-Gene_List_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE77108_5_v_1_saha_human RummaGEO Drug Perturbation Signatures 1.0 null ARL6IP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37262 HT115 CCLE Cell Line Gene CNV Profiles -1.0 -2.06025 STAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22346 GTEX-PVOW-0126-SM-2XCFA GTEx Tissue Sample Gene Expression Profiles 1.0 0.8347 APOBEC3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3924 PMC9038526-mmc1.xlsx-postCOVID_LPS_vs_healthy_L-symbols_98_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null LDHA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70549 inferior colliculus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.869969 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4718-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COLO792 CCLE Cell Line Gene CNV Profiles -1.0 -1.37754 facial motor nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.986548 EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30509 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4342-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RNOR-2226-SM-2TF5O GTEx Tissue Sample Gene Expression Profiles 1.0 1.39936 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CE-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MITF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.11217 cell part LOCATE Predicted Protein Localization Annotations 1.0 null ventrolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.38255 STYX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78211 Thalamus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE175787_5_v_0_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null NEK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24526 BNC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93901 MAPK14_knockdown_139_GSE31912 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.11551 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7828-01A-11R-2139-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-SYMBOL_TBX4 Rummagene Transcription Factor Associations 2026 1.0 null GSE233679_14_v_15_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null SLC7A8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85958 all GWASdb SNP-Phenotype Associations 1.0 0.030894 orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.917588 SEMA3G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56923 dorsolateral part of Med Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.94763 GSE188870,GSE188871_4_v_5_kat7_mouse RummaGEO Gene Perturbation Signatures -1.0 null 496100338_HIP_probable Alzheimer's disease_no TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.121 HELZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55233 MCAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54429 COLO 792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.73437 hippocampus (hippocampal formation)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.31007 PTBP1_02_131 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.90689 TRIM16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01786 liver BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 H3K27me3_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AI-0006-SM-2I3FG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13536 SREBP2-21459322-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE77108_8_v_1_saha_human RummaGEO Drug Perturbation Signatures 1.0 null MGAT5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65239 KLHL31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67319 RASGRF1_KD_GDS2816_287_human_Hippocampus GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null RNF207 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09188 GTEX-QESD-1626-SM-2S1RB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42929 PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-ENSEMBL_TBX4 Rummagene Transcription Factor Associations 2026 1.0 null NRL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.9739 ERCC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44698 T-47D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.950173 VAMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41042 Perturb_14049_KD_DDX3X_SRP299259 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -9.13621 periventricular stratum of r4Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14147 GTEX-XUYS-0126-SM-47JWZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.0092 Uterine lavage TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.632 GSE60217_1_v_2_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null EBC1 CCLE Cell Line Gene CNV Profiles 1.0 1.73435 INO80C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.44033 H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.28896 Epididymal fluid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.523 Prostate adenocarcinoma_PRAD_TCGA-CH-5788-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DPH5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.73922 PMC12729234-10194_2025_2222_MOESM1_ESM.xlsx-Table_S3-Table_S3_MR_results_of_the_586_significant_genes_from_TG_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-X4EP-3226-SM-3P5YR GTEx Tissue Sample Gene Expression Profiles 1.0 2.52451 Sarcoma_SARC_TCGA-DX-A48N-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null terete nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16436 APCDD1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.0901 AU565 CCLE Cell Line Gene CNV Profiles -1.0 -1.44413 hsa-miR-608 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GSE180377_2_v_1_lipa_mouse RummaGEO Gene Perturbation Signatures -1.0 null Breast - Mammary Tissue GTEx Tissue Gene Expression Profiles 2023 1.0 3.08388 TOP1MT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7055 CDK5R1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48285 red nucleus, parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04358 GTEX-X3Y1-2026-SM-3P5YM GTEx Tissue Sample Gene Expression Profiles 1.0 0.83343 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OZ-01A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-PT-A8TR-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mp12 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.587 Lung adenocarcinoma_LUAD_TCGA-78-7161-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HOXA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40803 TRIM52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.85581 SCO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40257 CDC14C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63896 MON DepMap CRISPR Gene Dependency 1.0 3.37476 hsa-miR-595 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 CCDC18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37958 GTEX-XXEK-1826-SM-4BRVC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.826082 H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Glaucoma_Retina_GSE3554 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -3.63294 BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.1779 Lung adenocarcinoma_LUAD_TCGA-62-A46V-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE197630_1_v_0_ruvbl1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE230263,GSE230265_5_v_1_runx1_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16291 RXYLT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92334 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6223-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hippocampus (hippocampal formation)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.45305 PEA1 DepMap CRISPR Gene Dependency 1.0 2.48742 BMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44319 primary motor cortex (area M1, area 4)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.07285 skin_5e HPA Tissue Sample Gene Expression Profiles 1.0 1.35824 Cells - Cultured fibroblasts GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.698417 TOLEDO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.53717 hsa-miR-4457 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 C5orf15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12092 BICR 31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03827 STMN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08196 BT-20 COSMIC Cell Line Gene CNV Profiles 1.0 4.51153 PK-45P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.52393 GTEX-PWO3-1026-SM-2I5F2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.23944 Brain - Hypothalamus GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.779411 FBXO10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61347 corpus callosum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13387 SLC29A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38643 OTX2_silencing_GDS4472_136_human_D425 medulloblastoma (MB) cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null RIC8B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88613 anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.26708 Barrett's epithelial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.366 MEPCE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44463 PMC4269325-NIHMS634665-supplement-supp_table4.xls-H3K27me3_TRIM37_KD-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null zfpm2_19411579_heart_lof_mouse_gpl1261_gds3659 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -1.06827 VIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.860151 IRS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32762 FOS::JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.0699 GTEX-XUYS-0002-SM-47JXL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.924936 GTEX-U8XE-0326-SM-3DB8P GTEx Tissue Sample Gene Expression Profiles 1.0 1.09774 disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040489 SCC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34969 Brain Lower Grade Glioma_LGG_TCGA-HW-A5KK-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.016 HM7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null IF-45-JC86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.257187 anterior part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14288 PMC7914369-thnov11p3676s2.xls-BPTF-KOvsCtrl-AccID_BPTF Rummagene Transcription Factor Associations 2026 1.0 null GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2046 OVISE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09829 GSE147876,GSE147877_2_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null PMC9882185-media-2.xlsx-All_B2-AR_targets-gene_id_AR Rummagene Transcription Factor Associations 2026 1.0 null LMNB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25907 EP300_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RIC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18347 NCIH1563 CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 TCF21-26020271-HCASMC-HUMAN-CORONARYARTERY ChEA Transcription Factor Targets 2022 1.0 null skeletal muscle HPA Tissue Gene Expression Profiles -1.0 -2.06088 GSE96649_1_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GSE215086_5_v_0_batf_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XQ3S-0426-SM-4BOOA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27184 primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.56421 GTEX-PVOW-0011-R3A-SM-32PKX GTEx Tissue Sample Gene Expression Profiles 1.0 0.859824 Cholinergic synapse COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.644 GTEX-WHSE-3126-SM-3P5ZI GTEx Tissue Sample Gene Expression Profiles 1.0 1.01576 GTEX-TSE9-3126-SM-4DXSY GTEx Tissue Sample Gene Expression Profiles 1.0 3.32134 MM253 DepMap CRISPR Gene Dependency 1.0 3.57177 LACTB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99515 Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3466-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42073 ZFYVE19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75053 thalamus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-T6MN-0005-SM-32PLJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.93412 GTEX-PLZ5-2026-SM-2S1O4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07321 GTEX-P4PP-1626-SM-2HMJF GTEx Tissue Sample Gene Expression Profiles 1.0 1.65104 primary auditory cortex (core)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.996182 liver HPA Tissue Protein Expression Profiles -1.0 -0.880199 Secondary cell wall COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.816 Perturb_1230_KD_HNRNPL_SRP033393 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.64199 ZNF678 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.27478 COV413A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.61401 YY1 MotifMap Predicted Transcription Factor Targets 1.0 null Supramammillary nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.68957 intermediate stratum of m2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03622 NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.892117 MDA-MB-468 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.949256 GSE95077_1_v_4_amiloride_human RummaGEO Drug Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YH-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5L5-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of r9Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05437 MTHFS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15163 shell part of the anterobasal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25333 ZBTB14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.59567 GTEX-T2IS-2626-SM-32QPP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58342 GSE142210_4_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VUSH-0005-SM-3NB2H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18842 GTEX-WZTO-0011-R11A-SM-4E3K9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.42817 H3K4me1_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-XMD1-0011-R9A-SM-4AT49 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02499 primary motor cortex (area M1, area 4)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.836207 TBX2-33478486-IMR90-HUMAN-LUNG ChEA Transcription Factor Targets 2022 1.0 null amygdaloid complex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.06696 KMS20 CCLE Cell Line Gene CNV Profiles -1.0 -1.40397 E2F4 ENCODE Transcription Factor Targets 1.0 null GTEX-R55G-0008-SM-48FEX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07967 GTEX-T2IS-1026-SM-32QP1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00261 EZH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21987 ATP13A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72391 GTEX-XQ3S-1526-SM-4BOOC GTEx Tissue Sample Gene Expression Profiles 1.0 0.895898 Lung adenocarcinoma_LUAD_TCGA-NJ-A55R-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RWDD2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45785 Lingula (I), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2936 medial mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.06121 GTEX-Q2AG-0011-R11A-SM-2HMKZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.924786 HYAL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83573 SETD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75208 nih 3T3 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.95013 Uterus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE147876,GSE147877_2_v_5_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null striatum_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.923377 CTCF_GM06990_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EEF1AKMT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.88869 NCIH2030 CCLE Cell Line Gene CNV Profiles 1.0 1.81706 uterus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CORL24 CCLE Cell Line Gene CNV Profiles 1.0 2.14147 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6324-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null endoplasmic reticulum LOCATE Predicted Protein Localization Annotations 1.0 null SIHA CCLE Cell Line Gene CNV Profiles 1.0 2.59922 NCIH1341 CCLE Cell Line Gene CNV Profiles -1.0 -1.36299 PFDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29278 frontal pole, left, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.25379 HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41N-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null M059K Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.959863 STAT3-18555785-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-WVLH-0011-R10A-SM-3MJFM GTEx Tissue Sample Gene Expression Profiles 1.0 0.862246 superficial stratum of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1825 ZNF124 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75582 ATXN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94863 PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_and_sensitivity_analysis_for_IPF_susceptibility_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null MAX_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE210885_5_v_6_klf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null Bcl11b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.9893 PRRT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.13279 Hoxd13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.0104 VZ in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.28267 GTEX-XAJ8-0006-SM-46MVM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.885 TWIST1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6757 TBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17947 GTEX-VUSG-2526-SM-4KL1V GTEx Tissue Sample Gene Expression Profiles 1.0 1.02855 FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_fibroblast of skin of abdomen_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-4133-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4531 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.41146 Endopiriform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23004 nucleus subceruleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.919461 ESO51 COSMIC Cell Line Gene Mutation Profiles 1.0 null UNC5D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02985 ZNF770 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.5029 GTEX-XPVG-2126-SM-4B667 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0684 WAC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10158 NKX6-2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76716 Obesity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.049 MCF7 CCLE Cell Line Gene CNV Profiles -1.0 -1.54183 Lung adenocarcinoma_LUAD_TCGA-78-7156-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7620-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TEX19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19889 Stomach Smooth Muscle Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.43823 GSE197850_4_v_0_glucagon_human RummaGEO Drug Perturbation Signatures 1.0 null 496100362_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.21542 GTEX-XAJ8-0826-SM-47JY6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.25712 WDR90 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54736 GTEX-T6MN-0011-R1A-SM-32QOY GTEx Tissue Sample Gene Expression Profiles 1.0 0.832625 NEK6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43562 nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055923 GSE157777_1_v_3_foxa3_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF440 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33234 GTEX-QXCU-1726-SM-2TC6L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36794 BCL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49914 SLC49A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20887 LPAR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12184 NT5DC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22296 TRAM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7268 GTEX-SNOS-0003-SM-3NMAO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05331 Kidney Chromophobe_KICH_TCGA-KM-8476-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T5JC-2426-SM-3NMDB GTEx Tissue Sample Gene Expression Profiles 1.0 1.35599 OCI-AML3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE182680,GSE182683_0_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-4726-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 GSE109565_12_v_4_glyphosate_human RummaGEO Drug Perturbation Signatures 1.0 null primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.839113 EZH2 ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-VP-A876-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.037 anterior (rostral) cingulate (medial prefrontal) cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.845533 striatum_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.85535 TMEM168 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.966 r7 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.93386 Anterior olfactory nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5258 Lung squamous cell carcinoma_LUSC_TCGA-43-5670-11A-01R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Endopiriform nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25785 GTEX-OXRK-0006-SM-2HML1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50913 A4GALT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55816 periventricular stratum of r2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11315 GTEX-S341-0326-SM-2XCAU GTEx Tissue Sample Gene Expression Profiles 1.0 1.00931 PAX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF707 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.8773 MYC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97165 PRDX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4375 Perturb_5510_KO_Vdr/Med1_SRP282245 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 GTEX-T2IS-3126-SM-32QPK GTEx Tissue Sample Gene Expression Profiles 1.0 1.57604 caudal (posterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.13641 CTCF_GM12875_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T5JC-0011-R10A-SM-32PM2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.871821 CCDC24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4798 UPK3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89632 SP in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.93562 stomach BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.07371 Liver hepatocellular carcinoma_LIHC_TCGA-4R-AA8I-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cochlear nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.907713 SETDB1 ENCODE Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JA-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.134 SW-1353 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.861 CSRNP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99177 GSE210885_2_v_4_klf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC7403583-41598_2020_69884_MOESM2_ESM.xlsx-Sheet1-Supplementary_Table_1_Differentially_Expressed_Genes_FDR_q_0_05_in_U2932_ROCK2_KD_vs_Scrambled_shRNA_Constrols_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S4Q7-0008-SM-3NM8A GTEx Tissue Sample Gene Expression Profiles -1.0 -0.8722 inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.16373 SP in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.4232 GA-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.58501 ANKRD40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74027 retinol biosynthesis HumanCyc Pathways 1.0 null insular cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03374 NR4A2::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.2281 CTCF_fibroblast of the aortic adventitia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPVG-2626-SM-4B669 GTEx Tissue Sample Gene Expression Profiles 1.0 1.188 CTCF_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.895838 GSE227592_6_v_1_adar_human RummaGEO Gene Perturbation Signatures -1.0 null OELE CCLE Cell Line Gene Expression Profiles 1.0 2.2001 CTCF_cardiac fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin - Sun Exposed (Lower leg) GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.651042 FGF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61369 OCI-AML3 COSMIC Cell Line Gene Mutation Profiles 1.0 null GNB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99301 GSE182179_0_v_3_kdsr_human RummaGEO Gene Perturbation Signatures -1.0 null UBE2W CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9113 TMEM191B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16763 HCA-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.89097 GTEX-NPJ8-1426-SM-3MJHR GTEx Tissue Sample Gene Expression Profiles 1.0 1.66695 estradiol_homo sapiens_gpl14550_gse35034 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HQ-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Primary somatosensory area, lower limb, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37525 rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.42638 STX1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34673 CTCF_WI38_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.927305 anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.32934 intestinal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.318999 HS940-T COSMIC Cell Line Gene Mutation Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.82297 Abnormalities, Drug-Induced CTD Gene-Disease Associations 1.0 1.03009 PAX5_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UJMC-0005-SM-3GACU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.894562 GTEX-NPJ7-0011-R11A-SM-2I3E8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05022 GTEX-P78B-0008-SM-48TE1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49854 496100562_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.66187 NEUROD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4669 Lung squamous cell carcinoma_LUSC_TCGA-56-8628-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU-C5 COSMIC Cell Line Gene Mutation Profiles 1.0 null POMGNT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21545 GSE77108_4_v_7_saha_human RummaGEO Drug Perturbation Signatures 1.0 null extracellular space GO Cellular Component Annotations 2015 1.0 null PAX5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null fallopian tube GTEx Tissue Gene Expression Profiles 1.0 1.02309 GTEX-XYKS-0008-SM-4BRW6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54593 r7 part of spinal trigeminal nucleus, interpolar part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22019 GTEX-P4PQ-2626-SM-33HC9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.981089 MAPK7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4306 GSE240896,GSE240899_5_v_4_ccnt1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE182834,GSE182836_2_v_1_siah2_mouse RummaGEO Gene Perturbation Signatures 1.0 null r8 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.12714 TR146 DepMap CRISPR Gene Dependency 1.0 2.26245 ARSA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4173 CTCF_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XGQ4-0008-SM-4AT3Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31696 GTEX-V955-2426-SM-3GAEF GTEx Tissue Sample Gene Expression Profiles 1.0 1.50903 Yy1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.7226 SLC25A24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78319 ANKRD63 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.87733 GTEX-PLZ6-1526-SM-2S1OC GTEx Tissue Sample Gene Expression Profiles 1.0 1.03956 GTEX-S32W-1326-SM-4AD5Q GTEx Tissue Sample Gene Expression Profiles 1.0 2.84272 GTEX-WHSE-1126-SM-3NMBU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21995 superficial stratum of JcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27507 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XD-01A-22R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.46032 MYBL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ovary HPA Tissue Protein Expression Profiles -1.0 -1.61372 OCIMY5 CCLE Cell Line Gene CNV Profiles -1.0 -1.47364 Perturb_10941_KO_Fto_SRP094101 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 7.23265 Perturb_10876_KD_Glis2_SRP297106 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.86223 CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null heart_5a HPA Tissue Sample Gene Expression Profiles -1.0 -0.946314 NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09829 posteroventral (inferior) parietal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05085 MDAMB361 CCLE Cell Line Gene CNV Profiles 1.0 1.53856 extracellular region COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 GTEX-R55E-0011-R11A-SM-2TC6I GTEx Tissue Sample Gene Expression Profiles 1.0 1.32288 inner SZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.834538 GTEX-POYW-0726-SM-2XCEO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.897236 ARMCX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7084 RMC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48836 BRD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.38577 SDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2366 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.030942 TGOLN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.59612 parvocellular part of the r9LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17395 organelle LOCATE Predicted Protein Localization Annotations 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YY-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE193402_0_v_1_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null SNAI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.4326 TIGD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75784 nucleus of the inferior collicular brachium, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61394 Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A6C5-11A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32789 SLC17A9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45532 STRADA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02117 superficial stratum of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.361 PCI30 DepMap CRISPR Gene Dependency 1.0 2.27143 CTCF_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCRS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99814 C1R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1182 GTEX-S7SE-2526-SM-2XCDL GTEx Tissue Sample Gene Expression Profiles 1.0 1.51979 POLR2A ENCODE Transcription Factor Targets 1.0 null Intermediate reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43024 KYSE520 CCLE Cell Line Gene CNV Profiles 1.0 1.90173 GSE242199_9_v_11_ntrk2_human RummaGEO Gene Perturbation Signatures -1.0 null dorsal cochlear nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33946 Lung squamous cell carcinoma_LUSC_TCGA-98-A53J-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral IC periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10282 PUR1 MotifMap Predicted Transcription Factor Targets 1.0 null hsa-miR-4723-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 APH1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.46543 KNS42 CCLE Cell Line Gene Expression Profiles -1.0 -2.87151 dorsal thalamus_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.958714 GSE183994_1_v_0_scml2_mouse RummaGEO Gene Perturbation Signatures -1.0 null SFPQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89495 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 BMF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90655 ventrolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.827105 skeletalmuscle_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.27029 SIRT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.1998 posterior (caudal) superior temporal cortex (area 22c)_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.89015 MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of pedal digit skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RNOR-0008-SM-48FEY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00532 GSE202434,GSE202438_7_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null Perturb_3280_KD_RORC_SRP117629 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GTEX-WEY5-0006-SM-3GIKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13427 CTCF_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WQUQ-0426-SM-3MJFU GTEx Tissue Sample Gene Expression Profiles 1.0 1.04979 GTEX-XXEK-0926-SM-4BRWH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.9467 LRFN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51812 GTEX-SN8G-0001-SM-3NM8L GTEx Tissue Sample Gene Expression Profiles -1.0 -3.93172 Sox3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 15.9792 superior frontal gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.968081 UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.83479 Limbic system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC11063202-41420_2024_1940_MOESM2_ESM.xlsx-THP1-EP300_KOvsNontarget-gene_name_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRIM41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.89181 MM1S COSMIC Cell Line Gene Mutation Profiles 1.0 null NCIH1048 CCLE Cell Line Gene CNV Profiles -1.0 -1.80364 CPNE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.786 skeletalmuscle_c HPA Tissue Sample Gene Expression Profiles -1.0 -1.83201 GTEX-XMD1-0011-R10A-SM-4AT4A GTEx Tissue Sample Gene Expression Profiles 1.0 1.24326 Pith TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.551 GTEX-QLQ7-1726-SM-2S1QQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.868768 Lung adenocarcinoma_LUAD_TCGA-55-1592-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RTLS-0008-SM-48FET GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45654 Agranular insular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09535 mediodorsal nucleus of thalamus_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.21595 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3445-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S95S-1226-SM-4GICG GTEx Tissue Sample Gene Expression Profiles 1.0 1.21614 PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Nearest_Ensembl_HNF4A Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S4UY-0526-SM-3K2AN GTEx Tissue Sample Gene Expression Profiles 1.0 2.55685 Steatotic liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.093 Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GADD45GIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35177 NCI-H1838 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.950173 layer 1 of LOT Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19498 KLHDC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39301 occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.05325 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IK-01A-32R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JcP contribution to LTL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27507 HPAC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.950173 PFKFB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43935 membrane LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-Q2AH-0008-SM-48U2J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3145 Wolman disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.271 MAPK6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35964 Hyperplasia CTD Gene-Disease Associations 1.0 1.39254 inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.927467 GTEX-XLM4-2926-SM-4AT59 GTEx Tissue Sample Gene Expression Profiles 1.0 1.98644 PMC11385078-jciinsight-9-172336-s272.xlsx-1DEseq2_Report_AA_BL_vs_EA_BL-Unnamed_1_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A50G-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-UJMC-0008-SM-4IHKK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92049 WSU-NHL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.58057 GK5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71186 KARPAS-45 COSMIC Cell Line Gene Mutation Profiles 1.0 null SCOC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.30805 PAN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23592 TBC1D14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8319 GTEX-OHPK-2026-SM-3MJH7 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.11057 PLPPR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02208 FOSL2::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.0502 GTEX-PVOW-2526-SM-2XCF7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.8587 inner CP in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.995658 CTCF_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07274 GSE229468,GSE229471_2_v_3_znf587_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-RU1J-0008-SM-46MV9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35021 Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47V-01A-11R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAF::NFE2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.8578 GSE233548_2_v_0_plscr1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-P44H-2426-SM-2XCEJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.43096 ventropallial prepiriform area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08091 HDLM2 CCLE Cell Line Gene Expression Profiles 1.0 2.24078 Crus II, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.924932 FAHD2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41127 NCI-H820 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K27me3_megakaryocyte_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCNE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04909 TBX4-33478486-IMR90-HUMAN-LUNG ChEA Transcription Factor Targets 2022 1.0 null r5 part of posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49036 r7 portion of ambiguous motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.54219 GSE62843,GSE64370_0_v_1_furan_mouse RummaGEO Drug Perturbation Signatures -1.0 null inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.880149 lateral intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00356 HCC2279 CCLE Cell Line Gene Expression Profiles -1.0 -2.30771 Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MB-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Parasubiculum, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56965 BACH2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.3943 POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.058 TCF19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42684 PMC6344081-elife-40364-supp8.xlsx-PLZF-Si-diff-expressed-genes-Up-Symbol_ZBTB16 Rummagene Transcription Factor Associations 2026 1.0 null r6 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27919 GTEX-UJHI-0008-SM-4IHL1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31457 FD-15-HD09_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.08775 GSE233679_12_v_10_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-YL-A9WI-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WL46-2926-SM-3LK82 GTEx Tissue Sample Gene Expression Profiles 1.0 1.17779 head and face region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.17047 Perturb_11108_KO_Cpt2/Ppara_SRP303636 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.81095 RHOXF2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10149 NR2F2 ENCODE Transcription Factor Targets 1.0 null Procambium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.751 hsa-miR-423-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 MPG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9112 Primary cell wall COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.859 PAXBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29127 CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VI, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.910324 amygdaloid complex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.876872 GSE193351_4_v_0_ruxolitinib_human RummaGEO Drug Perturbation Signatures -1.0 null COQ7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.96846 mantle zone of Mam Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03895 dorsolateral prefrontal cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.06723 fastigial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.00329 Foxj2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.0596 Sarcoma_SARC_TCGA-MJ-A850-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null amygdaloid complex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.87609 CENPX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29852 Foxl2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.502 GTEX-XOTO-3026-SM-4B65M GTEx Tissue Sample Gene Expression Profiles 1.0 1.08479 ventrolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.867978 Orbital area, lateral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12415 CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NEO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07556 OV7 CCLE Cell Line Gene CNV Profiles -1.0 -1.37937 GTEX-OXRK-0826-SM-2HMK7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11029 Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WU-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Uvula (IX), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53191 ROS50 DepMap CRISPR Gene Dependency 1.0 2.19454 tonsil HPA Tissue Protein Expression Profiles -1.0 -0.7062 central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7881-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_CH12.LX_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Linear nucleus of the medulla Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.51048 FBXO6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39741 GTEX-UTHO-2926-SM-3P5Z9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.45887 GSE112365_0_v_1_sirt1_human RummaGEO Gene Perturbation Signatures -1.0 null Retrochiasmatic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.95105 dorsolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.64766 KHM-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null medial ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.43636 NCIH929 CCLE Cell Line Gene Expression Profiles 1.0 2.00613 STAR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16331 GTEX-Y8E5-0006-SM-47JWQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7657 SETX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53163 GTEX-OXRN-2626-SM-48TBX GTEx Tissue Sample Gene Expression Profiles 1.0 1.83952 GTEX-PWOO-0926-SM-2I3EC GTEx Tissue Sample Gene Expression Profiles 1.0 0.832564 KYSE-270 COSMIC Cell Line Gene Mutation Profiles 1.0 null basolateral amygdaloid nucleus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03182 CP in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.89225 ABL1_druginhibition_77_GSE24493 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.63148 GTEX-XUW1-0426-SM-4BOOT GTEx Tissue Sample Gene Expression Profiles 1.0 0.910867 Acute Myeloid Leukemia_LAML_TCGA-AB-3005-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S4UY-0008-SM-3NM8H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51583 GTEX-WWYW-0011-R1A-SM-3TW8G GTEx Tissue Sample Gene Expression Profiles 1.0 0.887652 GTEX-OXRN-0126-SM-48TDM GTEx Tissue Sample Gene Expression Profiles 1.0 0.829219 CIART CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7545 H1-4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61882 ECC10 CCLE Cell Line Gene CNV Profiles -1.0 -1.38617 Brain Lower Grade Glioma_LGG_TCGA-HT-8107-01A-13R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CAPS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29796 Gustatory areas, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24646 GTEX-P4QR-0008-SM-48TE2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21842 GSE248887_0_v_1_dkk1_human RummaGEO Gene Perturbation Signatures 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2910-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null diencephalon TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CA12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9781 Perturb_11288_KO_Dicer_SRP041679 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -13.974 posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.30279 metencephalon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.318407 RGMA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10718 RBM10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94831 496100317_FWM_no dementia_no TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.77488 largeintestine BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.23083 GTEX-P78B-0005-SM-2I5GM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.979767 LMO4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84804 GTEX-X585-0011-R1B-SM-46MVE GTEx Tissue Sample Gene Expression Profiles 1.0 0.83425 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YK-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GOPC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7943 SUPT7L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65541 FAM229A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64328 SH10TC DepMap CRISPR Gene Dependency 1.0 3.01485 MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.533065 hsa-miR-3667-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 JHUEM3 CCLE Cell Line Gene Expression Profiles -1.0 -1.54041 MAFG::NFE2L1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.4785 ZFP37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52837 GTEX-W5WG-1826-SM-4KL2Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.963363 RNF14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49322 Keratohyalin granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.539 central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.28409 DKC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59476 SLC35E1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11099 GTEX-S95S-0002-SM-3NM8K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61258 MET_knockout_259_GSE25583 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.32857 Nanog JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.2987 Nr5a2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.1533 ADRA2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07334 ut1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.558 hsa-miR-3132 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 GTEX-REY6-0005-SM-2TF54 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.972562 SHISAL2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.47973 GTEX-X5EB-0008-SM-46MU3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.924984 D283MED CCLE Cell Line Gene CNV Profiles -1.0 -2.13462 Perturb_9240_KD|OD_ENL|ENL_SRP074134 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.70305 PAX5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_11198_KD_Pten/Scap_SRP311091 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 Brain Lower Grade Glioma_LGG_TCGA-HT-8015-01B-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ECC4 DepMap CRISPR Gene Dependency 1.0 4.1238 GSE197630_1_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_choroid plexus epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of RMa Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.70171 carboxylic ester hydrolase activity GO Molecular Function Annotations 2015 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CF-02A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WWYW-0526-SM-3NB2W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30201 Pyramus (VIII) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.27136 ZNG1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60283 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5679-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OXRP-2326-SM-2S1NL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18703 Lipid storage disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.145 CTCF_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Folium-tuber vermis (VII), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14723 lateral periretromammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29166 dorsolateral prefrontal cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.38773 CTCF_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sepsis_Splenocyte_GSE4479 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.85182 MYC ENCODE Transcription Factor Targets 1.0 null ZNF417 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.94846 r7 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.90693 RPMI7951 CCLE Cell Line Gene Expression Profiles -1.0 -2.12095 SNAPC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55154 H3C12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29521 SPG11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73123 dorsal lateral geniculate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.40316 GSE81193_3_v_2_irf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null HMGN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.08615 TOMM34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7393 GSE164874_5_v_3_prednisolone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WY7C-2126-SM-3NB2R GTEx Tissue Sample Gene Expression Profiles 1.0 0.939596 NLRP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.97114 smooth muscle HPA Tissue Protein Expression Profiles -1.0 -1.61372 GTEX-RWSA-0008-SM-47JYX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.96971 GSE163240_2_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null ECE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62606 HCC202 CCLE Cell Line Gene Expression Profiles 1.0 1.4025 r7 part of trigeminal transition zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.96155 PRX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65048 GSE205540_2_v_1_phloridzin_mouse RummaGEO Drug Perturbation Signatures -1.0 null lateral ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.970288 Hand1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 30.6412 Agranular insular area, ventral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19039 Spinal Muscular Atrophy, Infantile_CNS - Spinal Cord (MMHCC)_GSE3075 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.2857 GSE94768_5_v_4_pofut1_mouse RummaGEO Gene Perturbation Signatures 1.0 null frontal pole, right, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.36759 TAF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50078 DAOY CCLE Cell Line Gene Expression Profiles -1.0 -1.84233 GTEX-O5YV-0008-SM-4E3HP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0726 NETO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82402 NCI-H2030 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.17626 GTEX-QEG4-0626-SM-2S1OY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2689 GSE227592_10_v_1_adar_human RummaGEO Gene Perturbation Signatures -1.0 null WAOSEL DepMap CRISPR Gene Dependency 1.0 2.52738 MATCAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5208 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5456-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.034207 cerebral hemisphere TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-QDT8-2926-SM-32PKC GTEx Tissue Sample Gene Expression Profiles 1.0 1.66173 TE-10 COSMIC Cell Line Gene Mutation Profiles 1.0 null FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ENTPD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72628 KCTD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22125 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RT-A6Y9-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2873-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FEZF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52078 Alpha/Beta hydrolase fold InterPro Predicted Protein Domain Annotations 1.0 null GTEX-OHPM-0126-SM-2YUN9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05254 r6 part of spinal trigeminal nucleus, pars oralis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04154 DMRTC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 5.10364 Lung adenocarcinoma_LUAD_TCGA-55-A4DG-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NT5C3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.32989 Cerebral cortex TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 hsa-miR-4709-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 CTCF_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SNMC-1226-SM-2XCFP GTEx Tissue Sample Gene Expression Profiles 1.0 0.954739 Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3Z7-01A-12R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Telencephalon TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 FXR MotifMap Predicted Transcription Factor Targets 1.0 null inner CP in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00252 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PROCR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16111 THRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 58.1978 GSE126621,GSE126920_1_v_3_dppa4_mouse RummaGEO Gene Perturbation Signatures -1.0 null SMIM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67912 placenta_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.17778 ZCCHC12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99069 trochlear nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.34461 Brain Lower Grade Glioma_LGG_TCGA-CS-6669-01A-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of gingiva_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NFK9-0008-SM-4E3JE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22536 Lung squamous cell carcinoma_LUSC_TCGA-37-A5EN-01A-21R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU1272 CCLE Cell Line Gene CNV Profiles -1.0 -1.45018 large intestine cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.321909 Perturb_11206_KO_Mapk3/Mapk1_SRP331927 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 ZGPAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37265 496100483_FWM_possible Alzheimer's disease_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.02383 GTEX-PWOO-0006-SM-2I3E3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.911848 ACHN CCLE Cell Line Gene CNV Profiles 1.0 1.43016 GTEX-RM2N-0006-SM-2TF5H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07053 CAR-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.83479 GTEX-WWYW-1326-SM-3NB2S GTEx Tissue Sample Gene Expression Profiles -1.0 -0.880832 forebrain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-XPT6-0008-SM-4B64Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2206 BT20 CCLE Cell Line Gene CNV Profiles 1.0 1.62253 GTEX-OXRO-0006-SM-2I5EM GTEx Tissue Sample Gene Expression Profiles -1.0 -2.04088 amygdaloid complex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.31059 HOP-62 COSMIC Cell Line Gene Mutation Profiles 1.0 null RRP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32243 inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.0928 hsa-miR-1291 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 GSE182680,GSE182683_5_v_13_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UGP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39588 superficial stratum of PcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.10095 GTEX-TKQ1-1426-SM-4GICK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09035 Brain Lower Grade Glioma_LGG_TCGA-FG-8181-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DACT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15857 496100342_PCx_no dementia_no TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.14714 GTEX-T2IS-2926-SM-32QPO GTEx Tissue Sample Gene Expression Profiles 1.0 1.27129 CTCF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NRF2 pathway WikiPathways Pathways 2024 1.0 null Nr2e3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.087 Sperm plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.114 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040063 GSE219274,GSE219276_2_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null Arsenic CTD Gene-Chemical Interactions 1.0 null PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null KMH2 CCLE Cell Line Gene CNV Profiles 1.0 2.04624 small intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.082832 superficial stratum of CoPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.8493 PMC8481886-Table_1.xlsx-A_subsets-fetal_MSC_UC_MSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null FEZF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 59.0792 FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPA ChEA Transcription Factor Targets 1.0 null GSE129241_4_v_2_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-S4P3-0008-SM-3NM8R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51017 Rectum adenocarcinoma_READ_TCGA-EI-6513-01A-21R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null c-MYC_KD_GDS2526_112_human_MCF-7 BREAST CANCER cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Medullary reticular nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.11261 superficial stratum of r7Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22139 PAX5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2832-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SUCS-1926-SM-32PM3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06093 ARFGEF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87184 NCIH1648 CCLE Cell Line Gene Expression Profiles -1.0 -1.76058 SLC31A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70004 GSE235550_1_v_0_hspa9_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XUJ4-2126-SM-4BOOX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.898821 SPOP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61849 temporal pole, right, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.27388 hsa-miR-484 TargetScan Predicted Conserved microRNA Targets 1.0 0.131849 Primary visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13484 Head TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-XXEK-0526-SM-4BRWD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.827192 RPA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75851 outer CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.47263 dorsolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.15534 CTCF_A549_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WCDI-0008-SM-47JYE GTEx Tissue Sample Gene Expression Profiles -1.0 -2.23793 GSE171269_1_v_3_pioglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73F-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63687 GTEX-T5JC-0001-SM-3NMAK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.889224 Nutrition disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.043 TFB2M CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82784 SSBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71114 IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.21355 Spinal stenosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.032 OTX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53974 HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.962204 GTEX-SNMC-0008-SM-4DM5A GTEx Tissue Sample Gene Expression Profiles -1.0 -2.25982 SERINC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36153 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45O-01A-21R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Foxo1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.2645 RASL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26214 nucleus of the stria terminalis, medial division, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30098 GRINA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37062 Bed nuclei of the stria terminalis, posterior division, transverse nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.16764 NCI-H920 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12083 Lung adenocarcinoma_LUAD_TCGA-97-A4M1-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WY7C-2326-SM-3NB2U GTEx Tissue Sample Gene Expression Profiles 1.0 0.920571 cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.948419 plasma membrane LOCATE Predicted Protein Localization Annotations 1.0 null MERO14 DepMap CRISPR Gene Dependency 1.0 3.50339 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A299-01A-21R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZR7530 CCLE Cell Line Gene CNV Profiles -1.0 -1.36949 SMARCA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88841 TENM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.724 H3K27me3_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.21638 alimentary canal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.471151 SORBS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.82275 Lingula (I) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0845 ZBTB18 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.5958 H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054658 A4-FUK COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE169334,GSE169336_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Folium-tuber vermis (VII) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18447 GTEX-WZTO-2926-SM-3NM9I GTEx Tissue Sample Gene Expression Profiles 1.0 0.83202 PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN2_n_EN2 Rummagene Transcription Factor Associations 2026 1.0 null Cellulose synthase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.363 Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FN-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GIT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20674 LZTS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86197 SLC12A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32761 Lung squamous cell carcinoma_LUSC_TCGA-43-A56U-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE175787_4_v_6_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null GSE193258,GSE193259_9_v_12_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.965349 ATP6V0A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07681 H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YKG1 CCLE Cell Line Gene Expression Profiles -1.0 -2.13654 GTEX-WHWD-0005-SM-3LK7D GTEx Tissue Sample Gene Expression Profiles -1.0 -0.93139 anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.37609 retromammillary area, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.57614 GSE217363_4_v_1_nlrp3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-VUSG-0003-SM-3NMDK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.873567 ATG9A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35346 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YQ-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null caudal ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.58218 GSE195568_3_v_10_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE132369,GSE132371_2_v_0_cccp_human RummaGEO Drug Perturbation Signatures -1.0 null Gustatory areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00322 intermediate stratum of RMa Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.15433 paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.47227 Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A67A-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null APOBEC3G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89653 dorsolateral part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.70191 ITLN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.363 lateral hypothalamic area, anterior region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.27335 intermediate stratum of r7Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33529 layer 4 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.74144 GTEX-XLM4-3126-SM-4AT6M GTEx Tissue Sample Gene Expression Profiles 1.0 1.98766 CYYR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.18977 GTEX-QVUS-0011-R3A-SM-3GAFD GTEx Tissue Sample Gene Expression Profiles 1.0 0.997358 ZNF135 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 64.7268 HCC1428 CCLE Cell Line Gene Expression Profiles 1.0 1.56556 Overnutrition DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.048 Lung adenocarcinoma_LUAD_TCGA-97-A4LX-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AFF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30355 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.27 OTX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6387 VZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.987212 TFAP4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.7544 PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_fibroblast of lung_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null colon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.375368 Perturb_11255_KO_Nr5a2_SRP131036 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.43768 NOL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52558 SK-HEP-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null ChIP_SOX17_20123909 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null REH COSMIC Cell Line Gene Mutation Profiles 1.0 null ARHGEF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45699 icSARS CoV_24Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.98038 GTEX-PVOW-2626-SM-32PL8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.30244 NEK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85331 intermediate part of r10B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.71929 CTCF_fibroblast of skin of abdomen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7969 ACTG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23436 PCM6 CCLE Cell Line Gene CNV Profiles -1.0 -1.71124 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null external granular (germinal) layer of lower rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.895602 H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4822-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Stat6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.101 fallopiantube_8c HPA Tissue Sample Gene Expression Profiles 1.0 2.18778 GTEX-Q2AG-2826-SM-2HMJQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.4999 ARL2BP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67186 GTEX-S4UY-0726-SM-4AD6X GTEx Tissue Sample Gene Expression Profiles 1.0 0.832582 HCC1419 DepMap CRISPR Gene Dependency 1.0 3.18332 H3K27me3_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tooth disease GWASdb SNP-Disease Associations 1.0 1.13689 FAM171B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38803 NOP16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40077 GTEX-QESD-0006-SM-2I5G6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57482 mantle zone of r7Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.90008 choroid plexus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.194764 CFL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35467 HDAC6 ENCODE Transcription Factor Targets 1.0 null HDAC2 ENCODE Transcription Factor Targets 1.0 null CP67-MEL COSMIC Cell Line Gene Mutation Profiles 1.0 null Retrosplenial area, dorsal part, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06074 OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.979755 GSE215086_5_v_6_batf_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-X88G-0004-SM-47JZ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06119 TSC22D3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69558 CTCF_GM12864_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ISHIKAWAHERAKLIO02ER DepMap CRISPR Gene Dependency 1.0 2.47352 GSE95077_5_v_4_amiloride_human RummaGEO Drug Perturbation Signatures 1.0 null Nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Chondrosarcoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.797 TCP11L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63562 mediodorsal nucleus of thalamus_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.11324 CCNDBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42455 MDH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10535 SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02876 Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.035 Fatty Liver CTD Gene-Disease Associations 1.0 1.17497 GSE152734,GSE152735_2_v_0_pbrm1_human RummaGEO Gene Perturbation Signatures -1.0 null Perturb_407_OE_DPP4_SRP353826 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GTEX-T5JC-0226-SM-32PMA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.925563 orbital frontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.837536 PEA15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67979 Diencephalon TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 abnormality of cardiovascular system physiology GWASdb SNP-Phenotype Associations 1.0 0.444937 TBX21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.5259 GSE148096_1_v_0_erlotinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE114013,GSE114014_1_v_4_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null IFI30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17322 SPDEF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.4619 OCUB-M COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE149359_3_v_0_asap2_human RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4960-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE126621,GSE126920_1_v_0_dppa4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-NPJ7-2826-SM-2I3FU GTEx Tissue Sample Gene Expression Profiles 1.0 1.0003 GSE214212_2_v_0_chd6_human RummaGEO Gene Perturbation Signatures -1.0 null EEF1B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47438 Rectum adenocarcinoma_READ_TCGA-DY-A1DD-01A-21R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LIMA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24428 PRKAR1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.80875 PPAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45924 GTEX-X88G-0008-SM-47JWN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.972944 C3A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.885372 Thymus-fast muscle cell Tabula Sapiens Gene-Cell Associations 1.0 1.88847 anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.41994 Brain Lower Grade Glioma_LGG_TCGA-TM-A7CF-02A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null brain_3c HPA Tissue Sample Gene Expression Profiles 1.0 1.03131 SHD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22173 Sarcoma_SARC_TCGA-X6-A8C5-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null HUT102 CCLE Cell Line Gene Expression Profiles 1.0 1.55273 GSE193351_1_v_0_ruxolitinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSTO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87494 CDKN1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73634 COX5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47355 nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Perturb_4526_KO_Chaf1b_ERP006640 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.59861 POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF132 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99372 mantle zone of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03572 GTEX-TMMY-0005-SM-33HBN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.910973 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DI-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RNF187 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70543 PMC6962646-mmc2.xlsx-StemCell_Genesets_2018-ZNF43_ZNF43 Rummagene Transcription Factor Associations 2026 1.0 null ventrolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.64757 Nerve - Tibial GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.692304 Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9R7-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WI4N-1026-SM-3LK7N GTEx Tissue Sample Gene Expression Profiles 1.0 0.91591 posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.921833 TCF4-23295773-U87-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Primary somatosensory area, lower limb, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.63964 Adipose - Subcutaneous GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.730509 Primary somatosensory area, lower limb, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.2791 MELHO DepMap CRISPR Gene Dependency 1.0 2.75065 ACO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.00126 HEC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.945876 Lung adenocarcinoma_LUAD_TCGA-86-8669-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE185519_3_v_2_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null superficial stratum of r5Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21177 PMC8016886-41419_2021_3630_MOESM6_ESM.xlsx-Sheet1-Table_S5_Differentially_expressed_genes_identified_between_HOXC6-low_and_HOXC6-high_expression_CRCs_using_TCGA_cohort_HOXC6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QVJO-0006-SM-2S1RC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46862 GTEX-R45C-0008-SM-48FF2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.944652 RABL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74282 THOC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49087 METTL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.162 GSE176008_7_v_2_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-O1-A52J-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE138019_3_v_6_nudt12_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE175787_11_v_6_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.854359 GTEX-P44H-0006-SM-2XCFB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.841683 C1orf56 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67029 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5888-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cuneiform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.837873 HNF4A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.0914 VAX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70696 ALKBH7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31607 CDK2AP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48942 GSE157594_6_v_2_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K27me3_erythroblast_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFG7-0001-SM-3P61S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28546 frontal pole, right, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.11791 TE-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null THBS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21487 HCC1897 CCLE Cell Line Gene Expression Profiles 1.0 1.75839 ABAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.84232 GTEX-PX3G-0008-SM-48U2L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.9734 STPG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.29764 GTEX-T2IS-0126-SM-4DM6O GTEx Tissue Sample Gene Expression Profiles 1.0 1.0494 UBL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48348 ZNF804A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90888 1321N1 CCLE Cell Line Gene Expression Profiles -1.0 -1.67664 PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD Rummagene Transcription Factor Associations 2026 1.0 null NSD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19707 KYSE520 DepMap CRISPR Gene Dependency 1.0 2.2905 ZNF791 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77529 GTEX-WOFM-1326-SM-3MJFR GTEx Tissue Sample Gene Expression Profiles 1.0 2.52503 GTEX-R55G-1626-SM-48FF4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06135 KLF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.27464 L1236 CCLE Cell Line Gene Expression Profiles 1.0 3.40794 TFEC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.6779 SCNN1D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63805 salivarygland_6a HPA Tissue Sample Gene Expression Profiles 1.0 0.898319 TASK1 DepMap CRISPR Gene Dependency 1.0 2.09804 MACIR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.32669 ABHD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90799 Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A47O-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r10 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.75799 GTEX-S341-1726-SM-3K2AK GTEx Tissue Sample Gene Expression Profiles 1.0 2.0071 GSE235390_4_v_2_lurbinectedin_human RummaGEO Drug Perturbation Signatures 1.0 null VZ in caudal cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16359 GTEX-QMR6-0011-R11A-SM-32PKK GTEx Tissue Sample Gene Expression Profiles 1.0 1.13713 retromammillary area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.06723 GSE235516_0_v_1_zdhhc2_human RummaGEO Gene Perturbation Signatures 1.0 null JURKAT DepMap CRISPR Gene Dependency 1.0 2.50022 HSD11B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.2762 hsa-miR-4688 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 GSE102870_1_v_2_nr1h4_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WWYW-0005-SM-3NB3K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14398 ZNF432 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53659 Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PE-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null M07E DepMap CRISPR Gene Dependency 1.0 2.0663 ventrolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.58211 Uterine Carcinosarcoma_UCS_TCGA-N5-A4RS-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-SG-A6Z7-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TMEM98 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24459 GTEX-RM2N-0008-SM-48FF3 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.18122 BNC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.7184 ventrolateral prefrontal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.5473 GTEX-NPJ8-0011-R3a-SM-2HMIW GTEx Tissue Sample Gene Expression Profiles 1.0 1.26416 RCOR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29771 GTEX-TKQ2-0826-SM-33HB6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.882012 Internal female genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 KLHDC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66589 posteroventral (inferior) parietal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.21276 Acute Myeloid Leukemia_LAML_TCGA-AB-2981-03B-01T-0748-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE191015_0_v_2_gsdmb_human RummaGEO Gene Perturbation Signatures 1.0 null MONOMAC1 DepMap CRISPR Gene Dependency 1.0 4.56805 Presubiculum, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21281 S117 CCLE Cell Line Gene CNV Profiles 1.0 1.4358 L540 CCLE Cell Line Gene Expression Profiles 1.0 1.64481 TE10 CCLE Cell Line Gene CNV Profiles 1.0 1.5974 gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051049 TMEM25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28275 Carboxylesterase type B, conserved site InterPro Predicted Protein Domain Annotations 1.0 null CELSR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58066 hippocampus (hippocampal formation)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.13031 VZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.75229 Sarcoma_SARC_TCGA-FX-A8OO-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r2 liminal central gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11221 abnormality of the head GWASdb SNP-Phenotype Associations 1.0 0.122289 PNKP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59046 Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NN-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cerebral hemisphere TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-R53T-0008-SM-48FEW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.920621 PLEKHG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35389 mediodorsal nucleus of thalamus_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.0789 GSE104508_2_v_1_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null VEGFA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47288 H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.946808 Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WRHU-1226-SM-4E3IJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.73563 EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S3XE-0006-SM-3K2AA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01966 superficial layers of caudal presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.895919 H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intermediate stratum of r10BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56683 SNU16 CCLE Cell Line Gene CNV Profiles 1.0 1.50671 GTEX-OHPM-0006-SM-2HMKU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07673 Brain Lower Grade Glioma_LGG_TCGA-HT-7902-01A-12R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26004 ELAC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13599 spinal column TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.160224 VZ in subgenual cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.35967 COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.949256 G-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.28896 GPR162 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.96946 Prostate adenocarcinoma_PRAD_TCGA-YL-A8SC-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T5JW-1626-SM-3GADZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.59039 CTCF_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.867655 GTEX-U8T8-0008-SM-4DXSP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.956177 primary auditory cortex (core)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.856667 r6 part of the cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00628 GSE221742,GSE221743_1_v_0_sipa1_human RummaGEO Gene Perturbation Signatures 1.0 null PHF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69601 Perturb_11332_KO_Dicer_SRP041679 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -14.5917 layer 2 of VPrP cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37722 amygdaloid complex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.998007 GTEX-WFON-2126-SM-3LK7O GTEx Tissue Sample Gene Expression Profiles 1.0 0.878244 HCC1493 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.951009 LMO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06828 GTEX-OOBJ-2626-SM-2I3F6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.830909 inner CP in (rostral) midinferior temporal cortex (area 36) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.834017 Agranular insular area, dorsal part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28451 intermediate stratum of r9Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.71668 GSE77108_0_v_2_saha_human RummaGEO Drug Perturbation Signatures 1.0 null ATP5MGL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33349 GTEX-PVOW-2726-SM-48TCA GTEx Tissue Sample Gene Expression Profiles 1.0 1.33644 PTBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34031 H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_erythroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMAD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.25153 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YR-01A-12R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAVS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43109 SUM 229PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.2991 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null CDX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29339 GTEX-RVPU-0011-R7A-SM-2XCAB GTEx Tissue Sample Gene Expression Profiles 1.0 1.07051 GSE162276_2_v_3_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XAJ8-1426-SM-47JYM GTEx Tissue Sample Gene Expression Profiles 1.0 1.5496 GSE135439_0_v_1_pax5_human RummaGEO Gene Perturbation Signatures 1.0 null HLA-E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.50257 Perturb_10712_KO_Nrf2_SRP336215 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -10.8159 GSE248045,GSE248046_6_v_1_runx1_mouse RummaGEO Gene Perturbation Signatures -1.0 null hippocampus (hippocampal formation)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.38459 Perturb_11086_KO_Atf6_SRP332137 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.54072 PMC8684775-CTM2-11-e640-s002.xlsx-Sheet1-Table_S3_MAF_file_of_the_CCS_samples_MAF Rummagene Transcription Factor Associations 2026 1.0 null BORCS8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25803 skeletalmuscle_b HPA Tissue Sample Gene Expression Profiles -1.0 -1.53707 SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11543 GSE198380_0_v_1_phgdh_human RummaGEO Gene Perturbation Signatures 1.0 null SALL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82052 SNUC2A CCLE Cell Line Gene Expression Profiles 1.0 1.79922 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5178-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15117 GTEX-RWS6-2026-SM-2XCB5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04895 POLRMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84835 Inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.068 UACC812 CCLE Cell Line Gene Expression Profiles 1.0 2.20896 S117 DepMap CRISPR Gene Dependency 1.0 4.26582 CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Folium-tuber vermis (VII), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30121 anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.21038 abnormality of primary teeth GWASdb SNP-Phenotype Associations 1.0 0.412794 H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRSF7_02_133 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.80735 GTEX-N7MT-0011-R3a-SM-2I3GC GTEx Tissue Sample Gene Expression Profiles 1.0 1.02362 H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_BE2C_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPHK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92048 GTEX-WL46-3026-SM-3LK7Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.85177 GTEX-WYVS-1626-SM-3NM9R GTEx Tissue Sample Gene Expression Profiles 1.0 1.1533 IGSF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.37193 CXCL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68224 GSE178907_0_v_3_fkrp_human RummaGEO Gene Perturbation Signatures 1.0 null r9 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05437 GTEX-TKQ1-0008-SM-4DXSO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15974 B3GNT9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79999 GSE162276_2_v_0_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null ZMPSTE24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0245 Nr2e1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.049 HOP-92 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.869702 mantle zone of r10BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.71929 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09829 TGDS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04026 midbrain reticular formation, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.908213 Lung adenocarcinoma_LUAD_TCGA-55-1596-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T2IS-0426-SM-32QPE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.964644 BLOC1S2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3038 GSE224004,GSE224005_0_v_8_chd4_human RummaGEO Gene Perturbation Signatures 1.0 null striatum_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00358 WHSC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4FD-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2756-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormality of the oral cavity GWASdb SNP-Phenotype Associations 1.0 0.196662 PTTG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30054 HCC1171 CCLE Cell Line Gene Expression Profiles -1.0 -1.53364 brain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE149903_3_v_1_myd88_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-60-2714-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null delayed eruption of primary teeth GWASdb SNP-Phenotype Associations 1.0 0.993537 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70A-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FADU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11647 GTEX-R55C-0005-SM-3GAE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52105 PTK7_KD_GSE50138_674_human_H1299 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null FAM124B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49374 hippocampus (hippocampal formation)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.87531 PEX11A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57445 SW620 DepMap CRISPR Gene Dependency 1.0 3.67746 Primary somatosensory area, nose, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.16783 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE129241_1_v_2_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null MKN45 DepMap CRISPR Gene Dependency 1.0 4.34343 TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.8517 GTEX-PX3G-0126-SM-2I3EN GTEx Tissue Sample Gene Expression Profiles 1.0 1.09269 MDAMB134VI CCLE Cell Line Gene CNV Profiles -1.0 -1.76745 Perturb_18149_KO_Ikbkb/Shp2_SRP285005 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -8.97807 CW-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.04122 Duodenum Mucosa Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.01005 GTEX-WWYW-0011-R11A-SM-3NB38 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12755 PROX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56769 GTEX-SSA3-0008-SM-47JWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0817 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4813-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE171179,GSE171181_0_v_1_e7107_human RummaGEO Drug Perturbation Signatures 1.0 null RELA JASPAR Predicted Transcription Factor Targets 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4351-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_11310_KO_Dicer_SRP041679 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -16.8351 OSR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.0863 MME CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75507 SLC25A44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10241 GTEX-SUCS-0006-SM-4DM59 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28586 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE193258,GSE193259_9_v_13_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null Spinal nucleus of the trigeminal, oral part, ventrolateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27245 GSE81193_3_v_5_irf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-86-8280-01A-11R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DH-A7UT-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T6MO-0003-SM-3NMAG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01404 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44N-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XMD1-0008-SM-4AT41 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.958488 GTEX-NPJ8-0007-SM-2D7VX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63537 skin_6a HPA Tissue Sample Gene Expression Profiles 1.0 2.30573 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A430-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CKAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45398 Glucose Intolerance CTD Gene-Disease Associations 1.0 1.17794 GTEX-S4Q7-0003-SM-3NM8M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47985 GTEX-OXRL-0008-SM-3NB29 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.831082 PDP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00675 amygdaloid complex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.97334 GTEX-WVLH-2926-SM-3MJG5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.56243 Lung squamous cell carcinoma_LUSC_TCGA-63-A5MV-01A-21R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null caudal prosubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.50001 GTEX-XLM4-0008-SM-4AT4W GTEx Tissue Sample Gene Expression Profiles -1.0 -0.857636 TOX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28657 FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Slow twitch muscle fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.696 amygdaloid complex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.84563 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A6B5-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COV362 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.55204 ZBTB38 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83218 SCRT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.068 FLI1 ChEA Transcription Factor Targets 1.0 null Declive (VI) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10599 NCI-H630 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-XBEC-1526-SM-4AT68 GTEx Tissue Sample Gene Expression Profiles 1.0 0.896849 Cauda equina syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.436 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.126 lung BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.43325 496100344_HIP_probable Alzheimer's disease_TBI_100+_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.13259 LRWD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58624 CTCF_retinal pigment epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STRIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60049 EZH2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A69L-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF750 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91298 S100A13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76555 external part of AOV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40401 MSTO211H CCLE Cell Line Gene CNV Profiles 1.0 2.14112 CTCF_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null layer 3 of VPrP cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33529 H3K27me3_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAP7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9373 DUSP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95905 C4II DepMap CRISPR Gene Dependency 1.0 2.39793 abducens nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.89066 Dentate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25382 molecular_function GO Molecular Function Annotations 2015 1.0 null GTEX-P44H-0011-R11A-SM-2XCER GTEx Tissue Sample Gene Expression Profiles 1.0 1.18028 UCMA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89114 KCI-MOH1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.833868 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3EV-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary motor cortex (area M1, area 4)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.867655 WIPI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67623 GTEX-WZTO-0826-SM-3NM8Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45972 GGA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10859 STAT3 ENCODE Transcription Factor Targets 1.0 null e2f1_21245101_mmtv-myc_lof_mouse_gpl8321_gds4094 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.247557 mediodorsal nucleus of thalamus_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.837888 UTF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67743 GTEX-S4UY-0126-SM-3K2BB GTEx Tissue Sample Gene Expression Profiles 1.0 1.11997 ZFAND2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.36448 PIP4K2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.555 GTEX-T2IS-3026-SM-32QPM GTEx Tissue Sample Gene Expression Profiles 1.0 0.971907 TEAD1 JASPAR Predicted Transcription Factor Targets 1.0 null GSE154350_1_v_0_ascl2_human RummaGEO Gene Perturbation Signatures 1.0 null KIRREL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98426 hsa-miR-3652 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 STRADB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.19951 cerebellar cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.00165 GSE184892_4_v_2_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null abnormality of dental eruption GWASdb SNP-Phenotype Associations 1.0 0.369726 Perturb_10891_OE_Trim24_SRP355273 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.51164 FFAR4_KO_GDS4811_507_mouse_adipose GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-TML8-1926-SM-32QOS GTEx Tissue Sample Gene Expression Profiles 1.0 1.13212 GTEX-QEG5-0006-SM-2I5FZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.983541 GSE100863,GSE100864_2_v_1_tet2_mouse RummaGEO Gene Perturbation Signatures 1.0 null FOXP2-21765815-NEURO2A-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null orbital frontal cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.27281 GTEX-NFK9-0226-SM-2HMKQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.957477 adrenal gland HPA Tissue Protein Expression Profiles 1.0 1.61219 GSE93156_1_v_0_idelalisib_human RummaGEO Drug Perturbation Signatures 1.0 null BRF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01771 MONOMAC6 CCLE Cell Line Gene CNV Profiles -1.0 -1.432 EXOSC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78429 primary auditory cortex (core)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.17709 SLC25A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76046 VZ in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.833501 Perturb_11215_KO_Gpr151_SRP359303 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.31782 RHBDF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58372 SNU81 CCLE Cell Line Gene Expression Profiles -1.0 -1.56588 cerebral cortex TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CENPK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09777 Myosin XI complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.977 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4836-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CAL-39 COSMIC Cell Line Gene Mutation Profiles 1.0 null SLC48A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17293 GSE248858_6_v_3_tcpobop_mouse RummaGEO Drug Perturbation Signatures -1.0 null Perturb_11205_KO_Mapk1_SRP331927 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 9.51716 GSE119978,GSE180930_6_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Hippocampus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-W5WG-0008-SM-4KL25 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0135 GTEX-T6MO-1626-SM-32QOM GTEx Tissue Sample Gene Expression Profiles 1.0 1.10733 GTEX-T6MN-0126-SM-32PLP GTEx Tissue Sample Gene Expression Profiles 1.0 1.12579 Lung squamous cell carcinoma_LUSC_TCGA-63-5131-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DHX30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98672 Ejaculatory duct TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.539 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.152 GTEX-POMQ-0008-SM-48TE7 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.09508 CTCF_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary somatosensory area, nose, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.76641 Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M4-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XLM4-3026-SM-4AT6L GTEx Tissue Sample Gene Expression Profiles 1.0 1.29123 CDX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3395 GSE193351_1_v_2_ruxolitinib_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3316-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE224556,GSE224557_8_v_1_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KR-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nucleus of the lateral lemniscus, horizontal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30973 GTEX-PWO3-1526-SM-48TCM GTEx Tissue Sample Gene Expression Profiles 1.0 0.882818 Lung squamous cell carcinoma_LUSC_TCGA-85-8070-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HMOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95412 superficial stratum of r1BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.48442 inferolateral temporal cortex (area TEv, area 20)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.20335 Kidney Chromophobe_KICH_TCGA-KO-8413-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S7SE-0126-SM-2XCD5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.03409 NRF1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XOTO-0011-R11B-SM-4B64O GTEx Tissue Sample Gene Expression Profiles 1.0 1.1525 Jun JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.5351 lateral pallium Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15992 DRAM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63368 BCL2L13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17591 GSE60217_1_v_7_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null PRMT9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.01492 NCI-H1734 COSMIC Cell Line Gene Mutation Profiles 1.0 null RAD54L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58983 Lung adenocarcinoma_LUAD_TCGA-97-8552-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null deep layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.666 PSS008 DepMap CRISPR Gene Dependency 1.0 2.76564 GTEX-QXCU-0226-SM-2TC5W GTEx Tissue Sample Gene Expression Profiles -1.0 -0.905252 TMEM106C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00661 COLO 320DM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.866772 GTEX-XMK1-0008-SM-4GICF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.897163 Carboxylesterase, type B InterPro Predicted Protein Domain Annotations 1.0 null E2F transcription factor network PID Pathways 1.0 null IGFLR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7619 MIF4GD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29219 KLE DepMap CRISPR Gene Dependency 1.0 2.1498 GDM1 CCLE Cell Line Gene CNV Profiles -1.0 -2.50969 GTEX-XXEK-0008-SM-4BRW7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.969333 Basolateral amygdalar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03572 B4GALT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12086 Liver Neoplasms CTD Gene-Disease Associations 1.0 1.09226 TBPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46002 GSE214382,GSE214383_4_v_2_ascl1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE162276_2_v_3_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-3154 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 OXSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83604 CTCF_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PSDG-0726-SM-2I5FN GTEx Tissue Sample Gene Expression Profiles 1.0 0.826331 GSE193258,GSE193259_9_v_15_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-SUCS-0008-SM-4DM53 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.930954 TOMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55319 LS1034 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.962204 HDAC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86667 r5 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13075 C170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null LNCAP-CLONE-FGC COSMIC Cell Line Gene Mutation Profiles 1.0 null globose nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13398 GTEX-RNOR-2426-SM-48FDY GTEx Tissue Sample Gene Expression Profiles 1.0 1.46388 Central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Scd1_DELETION_GDS4910_309_mouse_Skin GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null TBPL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94226 mantle zone of LPrP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00705 18818702-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null GSE248858_1_v_3_tcpobop_mouse RummaGEO Drug Perturbation Signatures -1.0 null superficial stratum of Mam Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23212 BICR56 CCLE Cell Line Gene Expression Profiles 1.0 1.47254 GTEX-RWSA-0126-SM-2XCBB GTEx Tissue Sample Gene Expression Profiles 1.0 1.0932 GTEX-TSE9-0008-SM-4DXT8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.840111 GTEX-RU72-3126-SM-46MUB GTEx Tissue Sample Gene Expression Profiles 1.0 1.81546 HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CDS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40205 BAG6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45307 GSE162892_4_v_5_isox_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-SN8G-0008-SM-4DM4X GTEx Tissue Sample Gene Expression Profiles -1.0 -2.22007 hippocampus (hippocampal formation)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.44145 CTCF_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE156708_1_v_2_fbxo11_human RummaGEO Gene Perturbation Signatures 1.0 null head TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null hmc1 HPA Cell Line Gene Expression Profiles 1.0 0.926941 GSE165308_1_v_0_gfi1_human RummaGEO Gene Perturbation Signatures 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8XJ-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NAGA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98583 GSE182680,GSE182683_5_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WHSE-0006-SM-3NMBW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38675 H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09829 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6955-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE163240_3_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null NCIH1581 CCLE Cell Line Gene Expression Profiles 1.0 1.41107 GTEX-XBED-0006-SM-47JXO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08171 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6934-11A-01R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_10397_KD_LOXL2_SRP217697 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 PMC9130782-Table_3.xlsx-downregulated-ZNF366_ZNF366 Rummagene Transcription Factor Associations 2026 1.0 null MRPS24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63853 DYRK1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67181 STAT3 MotifMap Predicted Transcription Factor Targets 1.0 null Perturb_4525_KO_Chaf1a_ERP006640 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 8.28232 MAPRE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.38456 SMC3 ENCODE Transcription Factor Targets 1.0 null Plantlet TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.789 Brain Lower Grade Glioma_LGG_TCGA-HT-7856-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TOB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11769 FLI1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null F36P CCLE Cell Line Gene CNV Profiles -1.0 -1.66982 CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.28882 GTEX-WZTO-0126-SM-3NM95 GTEx Tissue Sample Gene Expression Profiles 1.0 0.966348 AKT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73399 Perturb_12039_OE_ADHFE1_SRP073667 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 PMC11063202-41420_2024_1940_MOESM2_ESM.xlsx-THP1-EP300_KOvsNontarget-gene_id_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null GSE70499_3_v_7_bmal1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-O5YW-0006-SM-3LK6E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.907107 Blood TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 mantle zone of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00491 CTCF_fibroblast of mammary gland_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null paraventricular nuclei, left of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08292 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXD4L5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53311 B-lymphoblastoid cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.765 spinal cord TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056019 SNG-M COSMIC Cell Line Gene Mutation Profiles 1.0 null ESRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83424 GTEX-WHSE-2926-SM-3NMBG GTEx Tissue Sample Gene Expression Profiles 1.0 1.17378 PMC9019027-42003_2022_3332_MOESM3_ESM.xls-Table_S1_HUVEC_MED23-KD_DEGs-gene_id_AR Rummagene Transcription Factor Associations 2026 1.0 null orbital frontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.48881 Brain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 RFX7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.3379 EXOC7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05015 SKNMC CCLE Cell Line Gene CNV Profiles -1.0 -1.59267 KLF13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.1594 FOXA2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DNAJB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16232 hsa-miR-1193 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 TPD52L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17606 HDGFL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45667 CIAO2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45926 skeletal system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054278 GTEX-WHSB-1326-SM-3LK6W GTEx Tissue Sample Gene Expression Profiles 1.0 0.898379 Prostate adenocarcinoma_PRAD_TCGA-WW-A8ZI-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.97468 Hic1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.0408 496100390_PCx_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.9242 SIHA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.10317 GTEX-RN64-1826-SM-48FDV GTEx Tissue Sample Gene Expression Profiles 1.0 0.932685 GTEX-XLM4-0011-R3B-SM-4AT6E GTEx Tissue Sample Gene Expression Profiles 1.0 0.830672 DENND5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0771 Pancreatic adenocarcinoma_PAAD_TCGA-LB-A7SX-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TRIT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48413 C19orf73 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67323 H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FOXH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.958 Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E8-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Neuroepithelioma cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-WZTO-3026-SM-3NMA2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08671 HGS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71978 GTEX-XXEK-0004-SM-4BRWO GTEx Tissue Sample Gene Expression Profiles -1.0 -3.20112 Perturb_10945_KO_Asgr1_SRP324468 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 7.53553 GSE242199_2_v_0_ntrk2_human RummaGEO Gene Perturbation Signatures -1.0 null whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052852 VPS26A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44943 PDSS2_KO_GDS3454_120_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-OXRP-0006-SM-2I3FN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32957 RTL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49487 TNIK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15701 Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HG-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pyramus (VIII), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.96892 anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.53004 Lung adenocarcinoma_LUAD_TCGA-97-A4M2-01A-12R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZSCAN4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.3178 NF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.86499 CTCF_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UJHI-1526-SM-3DB99 GTEx Tissue Sample Gene Expression Profiles 1.0 1.14741 HLF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21211 primary motor cortex (area M1, area 4)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.81687 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A97Q-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DFCI024 CCLE Cell Line Gene Expression Profiles 1.0 1.81289 GTEX-Q2AG-2926-SM-2HMJ3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.10195 GTEX-W5X1-0001-SM-3P61V GTEx Tissue Sample Gene Expression Profiles -1.0 -2.07105 GSE175787_11_v_2_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null H4C11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85171 Perturb_10720_KO_Setd2_SRP220107 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.40325 FOSL2::JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.1989 GTEX-RU72-0008-SM-46MV8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26048 hematopoietic system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null digestive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.221989 MPPE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59246 PLXNA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41489 HMY-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.949256 GSE133213_11_v_3_znrf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null ALS2CL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.50826 parietal neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.978868 H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null oculomotor nuclear complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.29584 GSE76425_0_v_7_lenalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE77108_3_v_1_saha_human RummaGEO Drug Perturbation Signatures 1.0 null GSE195514_0_v_1_stk25_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-PVOW-0008-SM-48TE8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50613 Prostate adenocarcinoma_PRAD_TCGA-VP-A878-01A-31R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of r6Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57953 HDLM2 CCLE Cell Line Gene CNV Profiles -1.0 -1.52194 Prostate adenocarcinoma_PRAD_TCGA-CH-5790-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEBPZ_02_118 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 4.45943 Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A4JJ-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pollen tube COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.573 GTEX-WL46-0626-SM-3LK7R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23067 GSE145249_0_v_3_ppm1g_human RummaGEO Gene Perturbation Signatures 1.0 null primary auditory cortex (core)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.831338 GTEX-T5JC-2526-SM-4DM6G GTEx Tissue Sample Gene Expression Profiles 1.0 2.10523 Liver hepatocellular carcinoma_LIHC_TCGA-NI-A4U2-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null fallopiantube_8e HPA Tissue Sample Gene Expression Profiles 1.0 1.18291 Prostate adenocarcinoma_PRAD_TCGA-G9-6354-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ischemic neuropathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.048 cardiovascular system disease GWASdb SNP-Disease Associations 1.0 0.048179 GTEX-XV7Q-1826-SM-4BRUV GTEx Tissue Sample Gene Expression Profiles 1.0 0.89402 NUDT21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80526 artery disease GWASdb SNP-Disease Associations 1.0 0.089672 ASRGL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01882 Arcuate hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50703 GTEX-N7MT-1226-SM-2D7W4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.38257 anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.2243 GTEX-S7PM-0526-SM-3NM92 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07751 GTEX-SNOS-0008-SM-4DM6I GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09647 ESR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68699 GSE210655_3_v_2_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null PMC12276197-18_2025_5784_MOESM1_ESM.xlsx-Sup_Table_10-Supplementary_Table_10_ERK_targets_from_Unal_et_al_2017_mapped_to_human_orthologous_genes_from_KD_and_SC_hypernetworks_AR Rummagene Transcription Factor Associations 2026 1.0 null MXD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98131 GATA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.082 lateral superior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.81991 catalytic activity GO Molecular Function Annotations 2015 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TMEM123 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73636 GTEX-NL4W-0011-R11A-SM-2I3DW GTEx Tissue Sample Gene Expression Profiles 1.0 0.830667 GTEX-SJXC-0526-SM-2XCFG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11753 GTEX-WCDI-0426-SM-4GIAL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.824211 hsa-miR-3155b TargetScan Predicted Conserved microRNA Targets 1.0 0.181316 DST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.36703 RFX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.2353 intermediate stratum of r5Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16224 inner CP in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.972733 SLC18A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45393 SW620 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_retinal pigment epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4821-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Hematopoietic system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MAC2A DepMap CRISPR Gene Dependency 1.0 2.76828 GSE220806_1_v_3_progesterone_human RummaGEO Drug Perturbation Signatures -1.0 null NBN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06686 parabigeminal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.62855 GTEX-R45C-0006-SM-3GAD6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.93176 GSE131903_0_v_2_abca12_human RummaGEO Gene Perturbation Signatures 1.0 null PMC5732738-oncotarget-08-103415-s002.xlsx-CAMA1_DEGs-Genes_differentially_expressed_by_1_25_fold_between_parental_CAMA1_cells_and_GATA3_mutant_knock-in_clone_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null RASA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.33124 GTEX-XUW1-0926-SM-4BONX GTEx Tissue Sample Gene Expression Profiles 1.0 0.997459 pontobulbar body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.00989 Bladder GTEx Tissue Gene Expression Profiles 2023 1.0 3.2092 HSPA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86257 GTEX-TSE9-3026-SM-3DB76 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01089 GATA3_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TC205 DepMap CRISPR Gene Dependency 1.0 2.19661 TBC1D25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76973 cochlear nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.42302 cerebellum HPA Tissue Protein Expression Profiles -1.0 -1.61372 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4787-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KYSE-30 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer 3 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23504 Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DQ-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IL-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Immune System Diseases CTD Gene-Disease Associations 1.0 1.02559 ATM_knockout_75_GSE23116 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.06627 Lung GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.732037 GTEX-X4XY-0008-SM-46MVL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.99061 GTEX-OIZG-0008-SM-4E3J2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35378 RFX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.3213 SF767 CCLE Cell Line Gene Expression Profiles 1.0 1.4224 Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.22 RNF215 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90538 hippocampus (hippocampal formation)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.07139 hsa-miR-4430 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GSE248858_5_v_3_tcpobop_mouse RummaGEO Drug Perturbation Signatures -1.0 null ZNF589 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51569 GSE210885_0_v_4_klf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZNF331 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86301 ARHGAP45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42261 GTEX-WHPG-2626-SM-3NMBR GTEx Tissue Sample Gene Expression Profiles 1.0 1.30754 ventrolateral prefrontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.03752 NCIH322 CCLE Cell Line Gene CNV Profiles 1.0 1.50627 Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U5-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE217526_0_v_1_parthenolide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-P4QT-1826-SM-2S1NJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.905958 HPN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.49934 liminal part of the r7 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42856 E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE202434,GSE202438_6_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null Brain - Cerebellar Hemisphere GTEx Tissue Gene Expression Profiles 2023 1.0 2.29686 CBX3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-A8I2-01A-12R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RFX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.4698 PGLS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55631 GSE214442_0_v_1_pak4_mouse RummaGEO Gene Perturbation Signatures -1.0 null PARP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68379 central nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058185 GTEX-XOTO-0008-SM-4GICE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.967772 anterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.870095 Liver Diseases CTD Gene-Disease Associations 1.0 1.1437 ZNF416 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.0841 GTEX-X4XX-0011-R2A-SM-3P623 GTEx Tissue Sample Gene Expression Profiles 1.0 0.851799 metabolic process GO Biological Process Annotations 2015 1.0 null GSE104508_0_v_1_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null Myelomonocytic leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.724 amygdaloid complex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.02821 H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null STAT3 ChEA Transcription Factor Targets 1.0 null GTEX-XQ8I-0926-SM-4BOOF GTEx Tissue Sample Gene Expression Profiles 1.0 1.13686 Fetal Growth Retardation CTD Gene-Disease Associations 1.0 1.16533 Zfp809 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 31.6348 occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.16446 IL17RA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39338 SYT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.83302 CTCF_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TSE9-2926-SM-3DB77 GTEx Tissue Sample Gene Expression Profiles 1.0 0.994042 GTEX-QLQ7-0005-SM-2S1QP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.926214 GTEX-U3ZN-0006-SM-3DB7Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.923039 Skeletal Muscle Female Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -0.885797 GTEX-T6MN-2526-SM-32PMN GTEx Tissue Sample Gene Expression Profiles 1.0 1.77542 MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF653 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31701 intermediate stratum of r7Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.28972 MTFP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46966 Perturb_10715_KO_Ogt_SRP216750 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 outer CP in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.846347 Lung squamous cell carcinoma_LUSC_TCGA-37-4141-01A-02R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dentate gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.24028 posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.899096 SW626 COSMIC Cell Line Gene Mutation Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.932476 TRIM28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38454 primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.834127 hippocampus (hippocampal formation)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.44853 SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WDR82 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56877 Cerebral lobe TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-PWN1-0126-SM-2I3FK GTEx Tissue Sample Gene Expression Profiles 1.0 0.938259 mammillary area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03986 r7 part of parapyramidal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.89071 GTEX-WOFM-0726-SM-3MJF8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.28127 CIBAR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49202 FOXI3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52635 GTEX-UPJH-0326-SM-3GADU GTEx Tissue Sample Gene Expression Profiles 1.0 0.88949 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DA-01A-31R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-P4QT-0126-SM-2I3FL GTEx Tissue Sample Gene Expression Profiles 1.0 1.06131 CASP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34559 pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5085-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2IP-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9882185-media-4.xlsx-Neuron_KD-ID_AR Rummagene Transcription Factor Associations 2026 1.0 null SCD_KO_GSE24243_46_mouse_Skin (8-9 wk) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-XPVG-0006-SM-4B65Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29576 FAM3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23348 VZ in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.19178 SREBF2 ChEA Transcription Factor Targets 1.0 null Bed nucleus of the anterior commissure Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12354 PAQR7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32347 Perturb_11056_KD_Eif4ebp3_SRP251186 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 GTEX-OHPK-0006-SM-2HMKH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.989993 COLO679 DepMap CRISPR Gene Dependency 1.0 2.21609