association	dataset	threshold value	standardized value
K562_Gandotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0280777
Liver disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.093
K562_Andarine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143198
K562_BMS-754807_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0258826
THUMPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67177
GSE111247_11_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Primary immunodeficiency disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.093
K562_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175903
MCF7_JNJ-26854165_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0263832
Yolk	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.824
GSE126345_4_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Roscovitine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149564
K562_Tucidinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176732
STAT1::STAT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.521
K562_UNC0379_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0254352
VAMP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52857
MCF7_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159776
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.551
K562_Dasatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166784
K562_WHI-P154_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0275795
MCF7_Avagacestat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0115124
SLMAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4385
GSE128634,GSE128636_1_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_SGI-1776 free base_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213077
PMC9038526-mmc1.xlsx-healthy_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PRRX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.932
K562_Avagacestat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156309
MCF7_Filgotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175148
GSE148269,GSE148273_0_v_1_arid4b_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176951
K562_PF-573228_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0235187
K562_Hesperadin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013142
Yolk granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.865
K562_Clevudine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182
MCF7_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0342363
Cauda epididymis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.069
GSE131161_3_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Nilotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196241
K562_AT9283_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173951
GSE140322_3_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111102,GSE111105_1_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Toremifene Citrate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0083627
MCF7_Bisindolylmaleimide IX_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0267864
K562_Belinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0718167
K562_AT9283_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176318
GSE166920_6_v_8_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Divalproex Sodium_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0492481
non-motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.172
K562_Streptozotocin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0364769
K562_PD98059_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0275024
Microtubule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
K562_Alendronate sodium trihydrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156938
PMC3419980-leu201249x2.xls-RUNX1-ETO_siRE_ChIPSeq_peaks_ge-gene_name_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Motile cilium	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Plasma membrane bounded cell projection cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Rootlet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.405
EBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30727
Axoneme	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
SLC26A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43106
NR2C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69322
PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-HIF1_HIF2_miRNA_targets_CoCl2-Unnamed_16_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
DMRTC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3072
K562_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0267676
GSE247764_5_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LMX1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.7042
K562_Ellagic acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165208
MCF7_WP1066_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018313
GSE129389_0_v_7_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLDIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64553
MCF7_SGI-1776 free base_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023343
K562_Roxadustat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0333941
a2780cis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.398
Myocardial infarction	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.61549
MCF7_TGX-221_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173663
K562_MK-5108_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0242262
Clopidogrel_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00650629
K562_BMS-911543_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019149
Cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Inner ear vestibulum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.874
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Toremifene Citrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130401
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Vinblastine (sulfate)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0182587
Pup	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.073
RRP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39063
MCF7_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0310167
DCUN1D4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55825
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNRPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28187
KRI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15389
Ataluren_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0135812
K562_Tofacitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154696
S-Adenosyl-L-methionine (disulfate tosylate)_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00933742
ETV2::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1287
K562_Ki8751_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195958
K562_EED226_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197517
MCF7_Filgotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0223224
HK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06838
K562_Cimetidine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179698
K562_Triamcinolone Acetonide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0243469
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-BrtoFay_Thermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Tofacitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0303495
K562_Disulfiram_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0369937
Plasma membrane bounded cell projection cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.76
GSE191105_2_v_4_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Lapatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0351346
SHOX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6253
Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.2623
GSE132759_4_v_5_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Dasatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125083
CLSPN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45041
Torkinib_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.012532
ZNF423	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23451
GSE160304,GSE163392_2_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
Triclosan_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0177042
Paclitaxel_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0123411
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_LF_species_not_found_in_common_genes_of_R_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166920_6_v_3_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
DBP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8658
K562_Alvespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194268
K562_Capecitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.026067
TIGD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01599
MPHOSPH9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79149
496100458_FWM_no dementia_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.57543
GNPTG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89288
POU1F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6244
MCF7_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0261543
TPBG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1887
FAM171A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69833
K562_ENMD-2076_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219443
Temuterkib_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0112861
GSE233679_5_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Primary biliary cholangitis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.093
PEO-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.082
SKIDA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40975
LSM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40564
K562_Raltitrexed_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0303813
cilium assembly	GO Biological Process Annotations 2025	1.0	null
Simotinib_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00731663
MFSD13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68452
cilium organization	GO Biological Process Annotations 2025	1.0	null
K562_SGI-1776 free base_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0343235
Celecoxib_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0159656
K562_Tacedinaline_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199217
TBXT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.606
GSE145323,GSE145324_1_v_0_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174522_1_v_0_spp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ELK3_ELK3	Rummagene Transcription Factor Associations 2026	1.0	null
Lumateperone (tosylate)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.010284
Hepatobiliary disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.093
K562_Abexinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0292014
COQ8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55423
K562_GSK J1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0228544
496100392_HIP_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.25982
ZER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18871
CRELD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25127
GSE171177,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE128634,GSE128636_2_v_5_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Katanin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.241
K562_KW-2449_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.035304
Axoneme	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.814
Axonemal outer doublet	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.557
Cilium	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
MCF7_Momelotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156059
K562_Raltitrexed_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0271845
PMC9038526-mmc1.xlsx-postCOVID_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
C1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1182
Ependymocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.146
K562_Danusertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0291273
GSE226091,GSE226092_3_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE143212_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6786946-NIHMS1535503-supplement-3.xlsx-SAT1_2_0x-FOXM1_genes_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154074_2_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_WHI-P154_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155131
GSE178255_3_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_WP1066_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0345143
RPP25L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31173
K562_Cediranib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0256434
abnormal mammary gland morphology	IMPC Knockout Mouse Phenotypes	1.0	null
K562_PD173074_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0379812
K562_PCI-34051_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0244261
K562_ZM 447439_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.029717
PDLIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27429
K562_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216726
MCF7_Pelitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0102383
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5608
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.998
K562_AG-14361_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0287706
K562_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0382405
MCF7_INO-1001_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143456
Gemfibrozil_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0131096
Stat5a::Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.359
SLK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65367
Intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Elf5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.8405
K562_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0236865
MCF7_Rigosertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0107202
MCF7_Ofloxacin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172772
K562_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019126
K562_Navitoclax_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193026
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.116
K562_Carmofur_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018456
GSE198971_0_v_2_ncor2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Tozasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191388
SNW1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24165
K562_Daphnetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0306853
K562_ABT-737_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0315074
K562_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0347733
K562_Azacitidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0567004
GSE155567_1_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TAK-901_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0399688
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6572
MCF7_Azacitidine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138666
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCF7_Ofloxacin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0280397
Cytoplasmic microtubule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
K562_A-366_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0532535
GSE154074_1_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.30738
Stomach	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE171724_4_v_5_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Inner nuclear layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.925
MCF7_Mercaptopurine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0366932
K562_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0291853
K562_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0460041
PMC10082806-42003_2023_4756_MOESM4_ESM.xlsx-AML2_RelvsTum_DMRs_anno-annot_symbol_RUNX3	Rummagene Transcription Factor Associations 2026	1.0	null
PRDX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36951
MCF7_Carmofur_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177922
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
VSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9141
MCF7_Momelotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0295356
496100480_HIP_no dementia_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.5147
MCF7_ZM 447439_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178706
MCF7_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147742
GSE240027,GSE240030_1_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188766
PCNP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45199
K562_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163264
K562_SRT2104_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0321853
MCF7_AC480_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181507
K562_Tranylcypromine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0315889
Zona pellucida	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.963
K562_Ki16425_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0336829
NEU3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72813
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
K562_MLN8054_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138467
GSE228181_3_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152441,GSE152442_1_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240022
abnormal thyroid gland morphology	IMPC Knockout Mouse Phenotypes	1.0	null
GSE88819_0_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_CEP-33779_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0282299
K562_Navitoclax_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0301412
PTPRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58244
GSE242333_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE155031_5_v_0_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_induced_genes-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Neonatal period electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.030452
GTSE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07071
K562_S3I-201_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0267187
PMC8851354-Table_6.xlsx-STAT3-bound_genes_GM12878-Supplementary_Table_6_STAT3-bound_unique_genes_in_GM12878_cells_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
PERP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50493
GSE178255_5_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Ki8751_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0292386
K562_Celecoxib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0452592
K562_S3I-201_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0234072
DCLRE1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21381
CD59	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54475
K562_BRD4770_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0253192
K562_MC1568_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0219925
K562_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200725
Filgotinib_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0350315
Floor plate	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.89
K562_BRD4770_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204367
K562_Trametinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0245947
PMC5787244-13229_2018_191_MOESM1_ESM.xlsx-FOXO1_GSEA_txt-PROBE_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6438015-13148_2019_651_MOESM7_ESM.xlsx-Sheet1-Table_S2_Genes_exhibiting_both_significantly_increased_promoter_methylation_and_significantly_lowered_expression_in_CRISPR_TET2-KO_cells_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210476_2_v_8_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Tranilast_LS 180	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00420255
K562_Curcumin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017749
ZNF136	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.338
Rarg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	78.4987
9+0 motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.102
MCF7_Ki16425_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148685
GSE207978_1_v_0_rai1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Unnamed_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_2_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
HAE cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.56
SMIM20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95923
K562_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0405539
PMC12518476-10067_2025_7574_MOESM9_ESM.xlsx-Sheet2-RNAseq_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202434,GSE202438_6_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_AC480_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198964
Inner medullary collecting duct cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.715
GSE95077_1_v_0_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nr5a1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.9102
MCF7_INO-1001_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170857
RPS17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60842
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0490483
K562_Fluorouracil_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157223
K562_Streptozotocin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194213
CCNA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.018
ALG10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6588
GSE121824,GSE121826_0_v_3_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7041704-JEM_20180649_TableS1.xlsx-IL10_rescued_LPS_downregulated-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
N6AMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23051
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE240645_1_v_0_u90926_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156544
K562_Luminespib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193664
K562_Resminostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.024336
GSE166920_6_v_1_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
TJP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01622
GSE140322_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Subcommissural organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.649
GSE208254_3_v_1_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Polymeric cytoskeletal fiber	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
496100519_HIP_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.96647
PMC8278601-13287_2021_2431_MOESM1_ESM.xls-Chrond-exos_vs_MSC-Exos-Unnamed_5_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Ileocecum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.309
K562_AR-42_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137092
GSE236072,GSE236075_2_v_0_ccr6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239844_8_v_12_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136129
abnormal spleen morphology	IMPC Knockout Mouse Phenotypes	1.0	null
K562_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208587
GSE152432_5_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Y-shaped link	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.756
MCF7_AT9283_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0107817
GSE184892_7_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sperm flagellum	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
K562_Selisistat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0334803
POU3F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.1535
GSE131649_6_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187637
Hydrocephalus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
MAP1S	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19975
K562_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162149
K562_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0331195
K562_S3I-201_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209047
GSE132759_4_v_2_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Animal cap	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.525
Ciliary shaft	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.894
Neratinib_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00662409
MCF7_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135406
(R)-Verapamil (hydrochloride)_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0101992
K562_Mercaptopurine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0489783
Cytoplasmic microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.072
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lonafarnib_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0181042
FXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68721
K562_Tucidinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147159
GSE224131_2_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Meprednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154058
MCF7_AMG-900_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.028749
GSE209698_0_v_1_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9533694-MOL2-16-3410-s013.xlsx-FIR20vsREST_DEMs-FIR20_vs_REST_DEMs_Down_REST	Rummagene Transcription Factor Associations 2026	1.0	null
Joubert syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.236
K562_Pracinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126618
Axonemal dynein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.709
RSBN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77214
Gastrointestinal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.093
GSE211931_1_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_PF-3845_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0301893
Prdm14	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.8706
K562_Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0237907
496100539_HIP_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06909
K562_EED226_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0304366
K562_Alendronate sodium trihydrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0237985
GSE166920_6_v_2_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Enzastaurin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160471
GSE231799_3_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Jun	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.522
K562_Trichostatin A_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152792
INCENP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57197
K562_Gandotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0360234
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_HA-SYMBOL_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
GOLPH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36529
MCF7_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210224
Ciliary rootlet	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.841
K562_Droxinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169033
K562_Nilotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0439342
Orofaciodigital syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.157
K562_Sodium Phenylbutyrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171077
K562_Selisistat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150993
BACH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.2937
GSE155031_5_v_3_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_SRT2104_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137129
MCF7_SGI-1776 free base_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016421
ARFIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15872
Ciliary necklace	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.925
K562_Andarine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0264954
GSE128634,GSE128636_2_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_HA-GENE_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
RAB25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23832
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCF7_TAK-901_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156084
K562_Cerdulatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0249186
Axonemal microtubule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PMC3470785-NIHMS377161-supplement-14.pdf-526-ZNF114_ZNF114	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
Radial spoke	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.903
MCF7_UNC0631_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0217648
K562_AMG-900_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174289
CGN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0739
K562_Resminostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141777
BICRAL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.27205
PMC3573965-1471-2407-12-422-S1.pdf-16-MYCL1_MYCL	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Tacedinaline_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.036938
K562_Maraviroc_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0237622
GSE209698_2_v_1_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Momelotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202392
K562_Ofloxacin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215362
chr15_81135816_G_A_b38	GTEx eQTL 2025	1.0	1.0245
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
K562_Lapatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178665
cilium	GO Cellular Component Annotations 2025	1.0	null
RBMX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.45078
PMC12410147-NIHMS2099518-supplement-3.xlsx-z-scores_DEGs_DGATi_LPS_vs_LPS-Z-scores_for_genes_differentially_expressed_when_comparing_DGATi_LPS_treatment_to_LPS_alone_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0241892
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.33
GSE240645_3_v_2_u90926_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ciliary tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.146
GSE132759_4_v_0_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201217_3_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cerebral degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.011
Photoreceptor inner segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.531
K562_Tie2 kinase inhibitor_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0287788
GSE149123,GSE149128_1_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE234289_4_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE176008_0_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_ITSA-1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021147
NAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22726
MED14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.73641
Tucidinostat_LS 180	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00794696
RPS12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50004
K562_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0394071
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4556
MCF7_Sorafenib Tosylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0303299
GSE180185_7_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Msgn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.7011
PPM1F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04352
ARL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0425
K562_GSK-LSD1 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0560039
PXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55372
K562_Entacapone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241753
GSE237984_1_v_0_magi1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_ENMD-2076 L-Tartaric acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0244093
TACC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31252
GSE202434,GSE202438_8_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Celecoxib_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0208431
NFATC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6655
GSE147943_2_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_AZ 960_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238024
CDC23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33626
ANLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58428
K562_Aurora A Inhibitor I_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165422
Ritonavir_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00691587
K562_Bisindolylmaleimide IX_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0287105
THOC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17667
GSE156708_1_v_2_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199513
GSE188382_4_v_0_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Utricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.144
K562_JQ1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.012591
Supramolecular fiber	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Synaptic ribbon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.539
K562_Givinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0335328
MCF7_Sorafenib Tosylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188658
RAB11FIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18282
MCF7_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144798
COPS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12195
OLFML2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37606
GSE154074_2_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE130437_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Gut microbiota (bacterial taxa, hurdle binary method)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.522185
Kartagener syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.987
MCF7_Ellagic acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186795
GSE229580_2_v_1_creb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Danusertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196453
MAD2L1BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09837
Ciliopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.172
Motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.869
GSE131377_1_v_3_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_GSK1070916_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0260856
GSE96641_3_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Sorafenib Tosylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0410094
GSE202603_1_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_BMS-911543_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191419
TMEM68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35359
K562_Crizotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125235
GSE149903_0_v_1_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DCAKD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0975
9+2 motile cilium	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Zic1::Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.7551
AKIRIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1955
K562_Bosutinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138233
Sperm principal piece	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.2
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7262
MCF7_Motesanib Diphosphate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0106997
GSE173232_2_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Givinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0443455
Acrosomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.625
K562_AZD1480_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0330771
Nkx3-2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.9406
K562_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0226441
K562_Cimetidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0214872
Tracheal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.099
TUBA1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	6.15339
PRXL2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85486
K562_AICAR_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160692
MCF7_Enzastaurin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150858
GSE147876,GSE147877_2_v_9_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Roscovitine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149194
HBQ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09713
K562_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0204377
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	71.7593
GSE88819_1_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A4GALT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03116
Prdm5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.3676
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0313869
K562_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0266662
GSE147876,GSE147877_4_v_9_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Tubastatin A HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0258573
GSE210655_3_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_WP1066_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189072
ZC3H13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78506
NLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3625
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5712
MAVS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60143
organelle assembly	GO Biological Process Annotations 2025	1.0	null
Ciliated cell_Trachea_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
Paclitaxel_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0209815
K562_Avagacestat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158144
K562_Barasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0323258
SEPTIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40649
SNRNP200	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29674
Inner dynein arm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.682
K562_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0318964
PSMD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45586
K562_Ramelteon_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205618
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE175787_11_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-Kasumi-1-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_Kasumi-1_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE198165,GSE198166_6_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PSMA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66043
CCDC137	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22071
K562_INO-1001_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0270087
TAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84805
K562_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0405004
Joubert syndrome 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.282
K562_PJ34_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154313
decreased total body fat amount	IMPC Knockout Mouse Phenotypes	1.0	null
K562_CUDC-101_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0682367
496100426_PCx_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.08295
K562_GSK-LSD1 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0978422
K562_Nilotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186746
K562_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169715
NRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66717
GSE239844_7_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TMEM249	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14239
MAP3K20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34614
GSE154074_5_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30515
GSE236502_1_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Tacedinaline_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140196
K562_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0475512
GSE131161_5_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PURB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30323
GSE234289_5_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184725
Niclosamide (olamine)_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.014099
MRPL36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06984
GSE226249_2_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MTRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6867
K562_Amisulpride_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0359941
ETV5::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.912
GSE160304,GSE163392_4_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
RIMS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36246
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4174
ATP5MJ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.289
ERBB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14511
GSE140576_0_v_2_plag1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Maraviroc_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176271
K562_Resveratrol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0356559
MCF7_SRT2104_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185529
PMC6080909-JEM_20171312_TableS1.xlsx-miR-196_predicted-Table_S1_miR-196a_b_predicted_targets_by_PITA_PicTar_TargetScan_and_DIANA_prediction_algorithms_ZFP1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_WP1066_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157088
K562_Resminostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0570463
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE162688_1_v_2_pink1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9170821-JCMM-26-3183-s001.xlsx-Endo_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
Male infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.381
Cecum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-HIF1_HIF2_miRNA_targets_CoCl2-Unnamed_12_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
USH2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.517
8-Hydroxyquinoline_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0143668
K562_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138511
TEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4212
K562_Aurora A Inhibitor I_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158555
MCF7_PJ34_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188068
K562_Enzastaurin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178063
K562_Baricitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0344169
496100305_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.11246
non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Kinocilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.58
K562_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179853
K562_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0452314
PPP4R2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38972
POLR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17547
CCDC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01053
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Ligustrazine_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0197694
K562_Daphnetin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195079
K562_Trametinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142082
Ciliated cell_Lung_Human	CellMarker Gene-Cell Type Associations	1.0	null
Zic3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.8026
K562_AC480_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0249881
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
9+2 non-motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.58
LIAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59108
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Decitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0343259
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.6552
496100355_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.47358
TRIML2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63116
K562_SRT2104_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0278694
GSE158458_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178267_2_v_0_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_CUDC-101_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0312324
Other source	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.167
GSE247764_0_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SMC1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42709
GSE201309_1_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Secretory granule lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.503
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_Azacitidine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0243496
UBE2W	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9113
Lonafarnib_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00415829
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.086
COG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63687
K562_GSK-LSD1 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0621268
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE108614,GSE108615_0_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161532
GSE231799_3_v_5_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Tadpole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.916
GSE188814,GSE188854_0_v_1_wtap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Fluorouracil_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118003
Neratinib (maleate)_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0164495
Econazole_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0182262
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.116
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_induced_genes-Unnamed_6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
sperm flagellum	GO Cellular Component Annotations 2025	1.0	null
FTSJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15552
ZBTB12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.026
SQLE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02354
K562_CYC116_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184757
K562_Bisindolylmaleimide IX_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166541
K562_JNJ-26854165_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0379154
GSE203308_7_v_5_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ciliary plasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.813
abnormal mouth morphology	IMPC Knockout Mouse Phenotypes	1.0	null
GSE145639_1_v_2_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cytoplasmic region	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_AA_NP-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6834
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_CEP-33779_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0319793
INSR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39571
Sperm flagellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.017
K562_Vandetanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0264653
K562_ENMD-2076 L-Tartaric acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152863
MCF7_SL-327_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0105184
Outer dynein arm docking complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.799
K562_Valproic acid sodium salt_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0256773
K562_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0459127
PARL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54024
Capmatinib_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.023898
K562_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0352715
Plantlet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.182
GSE208226,GSE208227_2_v_1_ell3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80095
Raltitrexed_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0114906
K562_Costunolide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157976
K562_Rigosertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171996
DAZAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03388
Spastic ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.39
K562_Pracinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0433041
GSE207282_1_v_0_polydatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27774
GSE206870,GSE206872_1_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Benproperine (phosphate)_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0077879
K562_Mesna_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0256376
K562_SB431542_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018813
K562_Alendronate sodium trihydrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137731
GSE96641_1_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ikzf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	44.6805
DNTTIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70118
FOXC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19493
K562_Clevudine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0229404
CDC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03532
K562_M344_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0280901
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
L-Eflornithine (monohydrochloride)_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00673241
K562_Cerdulatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169458
Sperm plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.541
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
GSE126345_9_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1358
K562_Momelotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167104
K562_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0384944
EIF3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34279
POU2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5415
K562_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0214597
Intracellular non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
K562_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0230637
PTGES3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54711
METTL27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32924
S-Adenosyl-L-methionine (disulfate tosylate)_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0149951
MCF7_Cerdulatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153552
POLDIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27765
GSE158431_2_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Navitoclax_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215723
GSE131649_6_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_UNC0631_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148816
ZMYND8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10923
R3HDM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54425
K562_CUDC-101_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182453
Outer dynein arm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.511
GSE152441,GSE152442_6_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
C2orf81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81668
MCF7_Glesatinib(MGCD265)_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127457
DNMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19814
K562_Carmofur_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0233074
LHX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7984
162 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.979
MCM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46929
K562_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0371529
K562_SRT2104_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163136
K562_Mocetinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133103
GSE219103,GSE219104_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Lenalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0289741
MED17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17638
K562_TG101209_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176238
PMC10247733-41408_2023_863_MOESM4_ESM.pdf-574-ZSCAN1_ZSCAN1	Rummagene Transcription Factor Associations 2026	1.0	null
K562_PF-573228_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0302744
SMG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27057
POTEI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15834
GSE223008_9_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0351
APIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06396
K562_Trichostatin A_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.028148
INSM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45023
K562_TG101209_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0291675
MCF7_AG-14361_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146996
K562_Enzastaurin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.033537
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCF7_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151273
Darinaparsin_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0204569
MCF7_2-Methoxyestradiol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121247
PMC5390115-mmc3.xlsx-DE_Lists_Exp_2-H1-EC2_3-fold_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Enzastaurin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0086577
PMC9170821-JCMM-26-3183-s001.xlsx-Endo_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
Acrosomal matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.984
AT7519_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0124821
GSE100863,GSE100864_2_v_1_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0277023
K562_Pelitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193477
K562_Valproic acid sodium salt_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172127
PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_PCI-34051_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135385
Esrrg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.9125
496100413_FWM_probable Alzheimer's disease_no TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.14052
K562_Divalproex Sodium_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146284
GSE247764_4_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perlman syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.034
Mucin granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.677
CELF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76518
GSE126345_2_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234289_4_v_1_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Aminoglutethimide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0301954
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
SRPK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50008
GSE162892_4_v_5_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
Dopaminergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.011
NOL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2754
MCF7_Mercaptopurine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120987
K562_Busulfan_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0361654
9+2 motile cilium	GO Cellular Component Annotations 2025	1.0	null
GSE152441,GSE152442_7_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Occipital pole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.829
K562_Ivosidenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151534
MCF7_MK-0752_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173938
MCF7_BMS-536924_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143015
K562_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167644
RPP40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03051
PMC3607232-mmc3.xlsx-RUNX1_targets_in_K562_and_SEM-x_1_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
NUDT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68763
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
EX229_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0188661
HOXC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17586
Autoimmune disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.093
CEP152	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09932
GSE131649_6_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176819
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
CCT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05457
GCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24834
SUPT16H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19328
MCF7_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171262
K562_Entinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0279202
CDX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.134
MCF7_Gandotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199786
K562_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145247
K562_Tozasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0263728
Axonemal microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.557
MDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07672
GSE185163_5_v_2_clic4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023269
MCF7_Entacapone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149193
K562_Resveratrol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0265205
PPP1R13L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27468
TXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79591
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.4383
POU3F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3654
SLC35A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00674
Uterine cervix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PPIP5K1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02587
GSE185163_3_v_1_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNRPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11476
GSE211474,GSE212779_0_v_1_phf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
plasma membrane bounded cell projection assembly	GO Biological Process Annotations 2025	1.0	null
MCF7_JNJ-7706621_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0282495
MCF7_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0242691
K562_Tucidinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.02573
GSE202434,GSE202438_15_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TBL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12233
K562_Tofacitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203934
TAF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01535
OSBPL8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37495
WDHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81064
K562_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159119
PMC11801220-NIHMS2038999-supplement-16.xlsx-Exc-MAF-gene_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE188458_2_v_1_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38889
H2BC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59098
ETV5::HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8206
Vermiform appendix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Immune system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.093
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8748
motile cilium	GO Cellular Component Annotations 2025	1.0	null
RARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7391
K562_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0251141
SACM1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15189
K562_S-Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197527
LCMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76647
ZIM3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.8943
K562_MK-5108_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0273379
MCF7_Tofacitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151697
Pronephric duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.759
Yy1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.4464
TLCD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41366
GSE88819_6_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DUX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3213
K562_Alvespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.02344
Mouth	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
K562_Givinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0356126
MCF7_Tanespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129424
K562_AG-490_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126716
ZNF789	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91925
K562_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0376254
MCF7_AG-490_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152362
K562_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0442706
Autoimmune disease of gastrointestinal tract	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.093
ING3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80407
EX229_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.014006
CLBA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54422
ARGFX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0527
MCF7_Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153748
GSE131377_1_v_0_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FGF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02616
PMC11067031-pnas.2317690121.sd05.xlsx-Sheet1-Differentially_expressed_genes_between_PML_RARA_GFP_vs_Empty_vector_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Resveratrol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0491012
MCF7_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185529
K562_TAK-901_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181301
Body mass index	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.769897
K562_CYC116_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0290217
K562_Alisertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0265596
Coronary artery disease	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.939794
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.387
GSE77108_4_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PROX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1674
K562_Nintedanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0259147
K562_Mercaptopurine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.039484
K562_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200746
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.5117
K562_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212751
RASIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10377
Cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
K562_Tanespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138208
ZBTB34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08294
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.568
Mozavaptan_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0229636
K562_PD173074_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0223815
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ERG_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Thiotepa_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149164
K562_Resminostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157514
GSE143994_2_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190534,GSE190536_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
LSG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06308
PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Supplementary_Table_9A_The_effects_of_whole_blood_transcripts_on_COVID-19_severity_with_suggestive_Mendelian_randomization_evidence_P_0_05_using_Genomicc_data_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
K562_JQ1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.012908
GSE162276_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_CUDC-101_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0114956
GSE140322_3_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ATP5MC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07498
MCF7_Amisulpride_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125522
GSE175787_8_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182936
TKFC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03855
MCF7_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0251075
K562_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178944
ATP5F1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32948
GSE131649_2_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GAPVD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25669
GSE96641_5_v_0_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Triamcinolone Acetonide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232324
GSE130437_2_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32253
K562_Azacitidine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164391
GSE109913_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE131161_1_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FAHD2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50471
496100431_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.13928
K562_UNC0631_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0261539
K562_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212128
K562_Avagacestat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0255229
MAN1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49794
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Ritonavir_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00825964
Heart	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TOMM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00186
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Vdr	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.0151
PMC8494348-pone.0257161.s002.xlsx-only_OXT_NOT_ext-OXT_ext-Gene_Name_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.4721
GSE247764_1_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE88819_7_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Busulfan_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.02112
K562_Ofloxacin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160119
GSE220600_1_v_2_clpp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Toremifene Citrate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0430392
Colorectal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.008
K562_Ki8751_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0201034
PAPOLB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56884
Liver cirrhosis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.093
Intracellular anatomical structure	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CHMP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14279
K562_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189723
PMC3644282-1471-2164-14-110-S3.xls-Contextual_Gene_Set_TCGA-GBM-IRF6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
K562_AZD1480_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178763
SIX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0289
ATP1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71311
GSE226249_2_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bruck syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
K562_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0234807
HOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.782
K562_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0231211
Supramolecular polymer	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE226091,GSE226092_0_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_ITSA-1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161864
Uterus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
K562_EED226_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018324
GSE95077_1_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8390401-12094_2021_2621_MOESM2_ESM.xls-S5-Supplemental_Table_S5_Differentially_expressed_genes_between_cases_with_CM-induced_pY-STAT3_DMFI_1_76_STAT3_Low_v_DMFI_1_76_STAT3_High_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_AG-14361_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0324415
GSE118765_1_v_5_rreb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NELFCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89416
B3GNT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53925
BI-78D3_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0117954
K562_Temsirolimus_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155695
K562_Abexinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0652966
GSE186151_1_v_0_methotrexate_human	RummaGEO Drug Perturbation Signatures	1.0	null
TMED9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08295
MSH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01674
K562_Tacedinaline_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0211708
RRN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88206
K562_Baricitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019892
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	52.4811
POU3F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9943
SUPT4H1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06208
GSE152441,GSE152442_1_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205436
K562_Entinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0626962
HDL cholesterol levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.752288
K562_Tozasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207409
AASS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06035
GSE228181_4_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178255_1_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_GSK-LSD1 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0859317
MCF7_Linifanib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.011552
MCF7_PF-3845_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143557
MCF7_Tazemetostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180092
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GATA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0476
MCF7_JNJ-26854165_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145617
K562_MC1568_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166269
LMX1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.8007
Heart disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.116
496100576_HIP_dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.84
ERK5-IN-2_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0265643
K562_Mocetinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0257043
K562_Cerdulatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180231
K562_Trametinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0217006
K562_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.02657
RPP38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47311
GSE156454_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196348
MCF7_UNC0631_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00941516
Outer acrosomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.84
K562_Danusertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0406376
MCF7_PCI-34051_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194055
K562_AZ 960_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216251
496100381_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.12865
K562_YM155_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0229857
Infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.276
Flagellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.943
MCF7_Rucaparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013049
MCTS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49044
496100542_PCx_no dementia_no TBI_82_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.1773
MCF7_Curcumin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150071
K562_GSK1070916_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015267
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5F-Up_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7041704-JEM_20180649_TableS1.xlsx-IL10_rescued_LPS_downregulated-Unnamed_6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Mucopolysaccharidosis type IVB	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.168
K562_SNS-314 Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0332772
PMC8191339-mmc1.xlsx-Table_S3_DE_genes-LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
enlarged spleen	IMPC Knockout Mouse Phenotypes	1.0	null
enlarged thyroid gland	IMPC Knockout Mouse Phenotypes	1.0	null
K562_AR-42_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0342495
GSE96641_5_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0241413
K562_Hesperadin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0438966
PCGF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18918
RANGRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1737
MCF7_Mesna_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178994
ARCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59341
Hydrolethalus syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.262
K562_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210129
MCF7_KW-2449_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151922
K562_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193964
GSE147876,GSE147877_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Rucaparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189364
K562_Entacapone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0263102
EIF2S3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35991
ZSWIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10992
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131161_2_v_6_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE240027,GSE240030_5_v_0_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
F-actin capping protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.352
GSE162276_5_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TMEM87A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15288
GOLT1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24781
SPC25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41366
K562_CUDC-907_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0521557
K562_Linifanib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0453345
GSE116354,GSE117379_2_v_4_cox2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SELENOW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54757
Thymol_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0213377
CMIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12558
GSE152441,GSE152442_6_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_JQ1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179744
TACSTD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18919
FAM98B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63766
MCF7_S-Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137675
Abiraterone acetate_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00466279
K562_G007-LK_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187042
K562_BRD4770_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172795
NEXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08168
GSE182921_0_v_1_slit2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCF7_CYC116_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012754
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE100528_1_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
pi1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.159
K562_Lapatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0613311
RNF113A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01227
Type I spiral ganglion neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
PFDN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13158
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.165
IGFLR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09815
Cardiovascular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ALG11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52788
Uterine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.539
GSE108675_3_v_0_slc1a4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Metanephron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.56
K562_Mocetinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210178
K562_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135578
K562_Capecitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153638
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1663
NECAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14512
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8664
MCF7_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126883
K562_Alisertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0317117
EP400	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20772
Microtubule cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
HNRNPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52579
PSMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70029
Type IB spiral ganglion neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LY2090314_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00858769
Almonertinib (mesylate)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0307621
PMC11801220-NIHMS2038999-supplement-15.xlsx-Exc-MAF-gene_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
LY2090314_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0173241
RFC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19114
Primary ciliary dyskinesia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.317
MCM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3264
K562_Trametinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0269777
MCF7_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0220157
MCF7_Cimetidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142785
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7208
K562_Vandetanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0276472
K562_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0267576
K562_Belinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0269772
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.022368
K562_TAK-901_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0328256
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Carmofur_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0116783
PLCD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27113
K562_BMS-265246_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182861
STIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30027
GSE162623_0_v_1_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE196701_1_v_0_atorvastatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_AZ 960_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173704
K562_Crizotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0273443
MCF7_Curcumin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201342
K562_Triamcinolone Acetonide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0268632
Early myoclonic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
K562_Trichostatin A_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181121
PMC11214527-mmc5.xlsx-ADNP-gene_ADNP	Rummagene Transcription Factor Associations 2026	1.0	null
Tailbud stage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.201
K562_Triamcinolone Acetonide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0253615
GSE149903_0_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SULT1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11071
MCF7_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154987
Mitoxantrone (dihydrochloride)_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0131439
K562_Tie2 kinase inhibitor_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0262946
GSE180200,GSE180201_15_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Tanespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160581
K562_Droxinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0269854
GSE182181_1_v_0_ricolinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Nintedanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.029976
CEBPD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5788
MCF7_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018843
K562_A-366_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0478233
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.33892
Tazarotene_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0222888
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.488
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3622
PLEKHF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22324
K562_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0226862
Cardiovascular system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.116
K562_Lomustine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014794
GSE140651,GSE140653_2_v_4_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NOP53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5078
MCF7_Disulfiram_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142017
Ciliary plasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
ZBTB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33751
TEX45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52587
Supramolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0