association	dataset	threshold value	standardized value
PMC5637904-PATH-243-193-s016.xlsx-human_down_in_fat_SOX11-Table_S5C_Downregulated_genes_in_tumours_from_DCIS-SOX11_cells_compared_to_DCIS-lacZ_cells_injected_into_mammary_fat_pad_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
GA-94-MC54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.3239
GSE182680,GSE182683_5_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF680	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.5338
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.8231
ZD-18-MI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.26658
GSE165548_2_v_4_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8752721-42003_2021_2991_MOESM4_ESM.xlsx-Fig3_E2F2-gene_E2F2	Rummagene Transcription Factor Associations 2026	1.0	null
ZMYM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55002
GSE217162_0_v_2_nivolumab_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-10-HD17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213175
DERL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16048
EB-09-OC36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208363
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.63594
SMAD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06147
SNU620	DepMap CRISPR Gene Dependency	1.0	2.03107
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.713554
AA-46-GL76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.589466
SRF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5069
INTS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45339
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11665559-jciinsight-9-183889-s131.xlsx-Fig2DiffBind_MYB_TR-PLEvsNTC-WT-Gene_Name_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262474
PMC5013636-ncomms12601-s5.xlsx-SP1-Groups_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135352_2_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE186810,GSE186813_2_v_1_furin_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162892_3_v_1_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KPL1_BREAST	CCLE Cell Line Proteomics	1.0	2.49844
POU2AF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30453
IFI27L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13111
GSE137914_0_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AD-31-GO06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218447
BT16	DepMap CRISPR Gene Dependency	1.0	2.37666
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE185139_1_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IM95	DepMap CRISPR Gene Dependency	1.0	2.05432
GSE133683_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BF-94-CQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266231
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.78276
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.654433
BC-54-ON71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345943
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.749496
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
6709_PPY_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.514245
LSM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50034
2954_CIAO2A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.742283
IPO13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07892
Nerve - Tibial	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.72083
GSE137144_5_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0576
KB-77-BA46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237096
TIM22 mitochondrial import inner membrane insertion complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.038
GSE221539_1_v_3_lrrc10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4595011-pgen.1005555.s003.xlsx-BPTF_DOWN-regulated-Ensembl_gene_id_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112761,GSE112767_4_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126463_6_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178340_5_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain - Amygdala	GTEx Tissue Gene Expression Profiles 2023	1.0	1.05183
GSE125011_0_v_2_cd83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158320,GSE183351_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.42492
DE-00-JU18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.553944
SKCO1_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.87663
GA-10-WX15_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.499072
Electrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.524
JF-76-BD96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218981
A549_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128125
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.465916
A549_Azacitidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150302
FF-22-NB12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.31809
GSE210505_0_v_1_sox1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217541,GSE217543_0_v_1_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
DF-00-BX35_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318205
K562_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202094
TC205	DepMap CRISPR Gene Dependency	1.0	2.16487
SLC8A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83403
GSE113106_0_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BC-00-YH62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.682349
GSE171837_3_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
LUDLU1_LUNG	CCLE Cell Line Proteomics	1.0	2.92799
AE-13-CX28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.363453
AC-43-ZC52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.450798
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
TP63-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
GSE159678_6_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE138818_2_v_0_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNG1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2606
CRELD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49323
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.157
IA-27-CK10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.483042
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hinge joint	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.812
Mitosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.957
GSE254517_1_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140607_5_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151782_2_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
X-linked sideroblastic anemia with ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.032
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.459322
Integral component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.829
CIAO2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54935
SAM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.944
LXF289_LUNG	CCLE Cell Line Proteomics	1.0	2.92799
GSE137144_3_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.064
PPARG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44621
GSE209898,GSE209899_0_v_1_flcn_human	RummaGEO Gene Perturbation Signatures	1.0	null
BE-66-UB12_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.544291
GSE230263,GSE230265_0_v_1_runx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199255,GSE199356_4_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Dendritic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.742
NCIH28	DepMap CRISPR Gene Dependency	1.0	2.11899
GSE165682_0_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174362_3_v_0_oridonin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CB-99-OG76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2231
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.507602
PPARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.883
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
9258_TRIAP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.510578
GRIK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10824
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
DB-21-FY25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.719605
GSE155567_3_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.412733
LB-04-KP05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2028
UNCX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.9685
GSE213715_0_v_1_iqgap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nuclear lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
A549_Glesatinib(MGCD265)_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136024
HE-84-RW47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.447657
AC-28-RT00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.653105
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1544
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.43715
GSE171724_4_v_6_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.810483
GSE224969,GSE224971_0_v_7_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE127790_5_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
METTL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3424
PMC9314667-Table_1.xlsx-Regulons-IRF3_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Meprednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138999
GTPBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05019
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JB-75-NC66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.507499
GSE82032_3_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HE-68-XL70_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289189
CITED4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06158
AB-17-WP43_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.350833
HD-26-KX74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.384635
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OUMS23	DepMap CRISPR Gene Dependency	1.0	2.16348
Lymph node	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.671
SCH	DepMap CRISPR Gene Dependency	1.0	2.28291
PC-80-LV29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.443739
CBX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34071
WDHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74242
WC-59-RG09_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.997921
GSE145311_1_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE127790_10_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SOX2-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178255_1_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AD-40-WB93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210159
GSE190186,GSE190188_0_v_10_apoe_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.24673
SD-69-QA40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256623
K562_Alendronate sodium trihydrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0229434
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.48412
2561_EIF4A3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.556706
FE-49-ZJ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.337532
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.590962
BC-20-WA90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.688073
GSE113329,GSE113335_2_v_4_taf6l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Delta DNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.058
GSE181513_0_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FF-54-JC89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.341256
496100315_TCx_no dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.72242
Intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GD-46-OD81_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.367783
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142019,GSE142021_1_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
gene expression	GO Biological Process Annotations 2025	1.0	null
WB-82-EL69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.778917
GSE219195_1_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217541,GSE217543_3_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119345_0_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE139987_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE212848_1_v_0_pum1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TICRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9516
GSE190186,GSE190188_8_v_5_apoe_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.09258
DA-19-JA87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.52197
SD-69-QA40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275836
GSE217156_2_v_3_trpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.18718
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE161295_4_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SREBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.9519
FOSL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2003
A549_Pirarubicin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157961
CE-23-HP88_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.353871
Gfi1b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.4549
PC-80-LV29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268909
EB-09-OC36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263202
GB-90-UG49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200017
GSE171837_0_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ANLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14354
MECR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30218
XPC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.062
GSE248858_4_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AB-17-WP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.396079
Rhox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.198
T-REx 293 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.317
496100602_TCx_dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.0961
AB-84-PK04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.536075
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.349641
CIA complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
LS123	DepMap CRISPR Gene Dependency	1.0	2.29044
BA-77-US35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28053
B-lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.811
A549_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138148
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.515004
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
XYLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50256
GSE240439_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE70499_5_v_1_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11665843-SYB2-18-218-s001.pdf-8-SP110_SP110	Rummagene Transcription Factor Associations 2026	1.0	null
Nucleoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_AA_NP-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
MLLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09663
BC-20-WA90_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233784
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.76917
PMC10928104-41419_2024_6576_MOESM4_ESM.xlsx-S14-E2F1_2_3_targets_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149903_5_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-20-VR86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.50357
GSE149854_1_v_0_batf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227592_6_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GB-94-XG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218205
MAF::NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8275
EE-98-PF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318913
GSE147210_3_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE144231_3_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
C84	DepMap CRISPR Gene Dependency	1.0	2.09811
K562_Azacitidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141324
Xeroderma pigmentosum	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.3
PMC4383005-ncomms7500-s3.xlsx-Supplementary_Table3-Supplementary_Data_2_HES5_vs_HES5-_expression_intensity_ratios_during_NSC_progression_HES5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182680,GSE182683_7_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AE-67-FF84_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241697
CNOT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.25986
Mhs	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.775
HF-00-QG19_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.595541
GSE167224,GSE168147_1_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE70499_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178255_5_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CD-13-QZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276383
GSE258991_5_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_11_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
CME1	DepMap CRISPR Gene Dependency	1.0	2.28204
AC-80-DI95_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287327
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_LF_species_not_found_in_common_genes_of_R_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE188832,GSE188835_0_v_1_irf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NTAQ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26029
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8797
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.2837
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CIA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.771
TIMM50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07307
GSE125157_1_v_0_piceatannol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE218949_0_v_1_cep20_human	RummaGEO Gene Perturbation Signatures	-1.0	null
8061_SLC37A4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.507385
UA-39-TN76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.539209
GSE190235_0_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF704	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27772
STAT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0219
GSE217105_0_v_1_gemcitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151612_4_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-04-NG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.673572
GSE227592_13_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Multiple mitochondrial dysfunctions syndrome 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.433
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
AP1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18458
GSE199538,GSE199539_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8497824-Table_4.xlsx-Stage_4_EOMES_vs_Ctrl-Unnamed_1_EOMES	Rummagene Transcription Factor Associations 2026	1.0	null
HGC27_STOMACH	CCLE Cell Line Proteomics	1.0	4.19233
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5144
GSE117643_1_v_0_irx5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120413,GSE120447_0_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE137914_4_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169334,GSE169336_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100464_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05582
MERO14	DepMap CRISPR Gene Dependency	1.0	2.29812
GSE201042_6_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AF-13-LM61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294797
SOGA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45274
BD-48-ZT65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.348072
PMC6080909-JEM_20171312_TableS1.xlsx-miR-196_predicted-Table_S1_miR-196a_b_predicted_targets_by_PITA_PicTar_TargetScan_and_DIANA_prediction_algorithms_ZFP1	Rummagene Transcription Factor Associations 2026	1.0	null
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.823914
MB-32-LQ97_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236252
GLTP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64493
CE-19-PD79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244054
KE-37-MN32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.613492
GSE70499_3_v_1_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Dmrt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.3365
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.513856
Sideroblastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.275
STOML1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60343
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.920576
AB-32-QZ50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219304
IC-05-AW29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231818
A549_UNC0379_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124549
GSE173810_4_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AU565_BREAST	CCLE Cell Line Proteomics	1.0	2.03384
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.386725
AB-12-IS33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.394865
TOM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.88
MEX3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87064
GSE185944_5_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZSCAN23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28117
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.311657
AB-84-PK04_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.403643
AF-67-LZ82_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208266
GSE188721_2_v_4_mesp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BD-48-ZT65_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227926
CD-16-KY17_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.359559
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174735_4_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EF-52-ML96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277958
PMC9314667-Table_1.xlsx-Regulons-MITF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BHT101	DepMap CRISPR Gene Dependency	1.0	2.11912
GSE107505_3_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AF-16-IB77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.710486
RHPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44107
GSE180641_0_v_1_zfp503_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JHUEM1	DepMap CRISPR Gene Dependency	1.0	2.43496
GSE158834_7_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE145311_0_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.338205
GSE169152_3_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FD-29-MM50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.447334
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nr2e1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.9821
GSE232223_1_v_0_letmd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-17-XI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253366
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE227891_2_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112860_0_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE175787_11_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273907
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220882
BC-13-OQ01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.419346
S0-EE-Y79N_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.410792
HUNS1	DepMap CRISPR Gene Dependency	1.0	2.50229
Stomach	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
DD-30-SX80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258067
GSE209911_0_v_1_ncstn_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242290_1_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
FB-12-UL66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223129
ATP1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0145
GSE146074_6_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.481102
WD-86-NH64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227969
Peripheral blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.742
GSE160373_6_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IC-80-CT90_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.31067
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.19293
MAFG::NFE2L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0775
CA-48-SW47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22817
K562_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162514
VB-89-RG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297714
NOL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29887
MCF7_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149671
Transcription export complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.969
AA-99-HO76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233586
GSE158834_7_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
5910_NXF1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.574603
AB-71-CI37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.3702
GSE178340_5_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE81796_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE227592_5_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
BE-50-RK99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.348691
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FC-20-EQ58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.516744
K562_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143621
PMC2702100-pgen.1000564.s005.xls-DBP_controls_1e-04-closest_gene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
HB-24-GP45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248129
GSE210580_0_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Tail	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.105
KIJK	DepMap CRISPR Gene Dependency	1.0	2.1798
Red Blood Cell Count Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
AC-28-RT00_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.324166
AD-55-EA62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330459
GSE102870_11_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186810,GSE186813_2_v_1_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE207914_5_v_6_nudt7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DLX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7104
SB-89-QK94_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.489988
GSE149943_2_v_3_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.327349
K562_S3I-201_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0316555
protein maturation by iron-sulfur cluster transfer	GO Biological Process Annotations 2023	1.0	null
PMC8160578-JCB_202009147_TableS4.xlsx-E2F1_targets-Genes_n_1867_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.314472
Integral component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.83
PMC9843885-40478_2023_1507_MOESM6_ESM.xlsx-CIC-OE_TS603-Unnamed_1_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE206226_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MRPL41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41677
GSE227592_9_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
NC-01-ET52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235227
OB-06-WW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230594
AA-18-GQ83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.573134
DDX27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22671
SINHCAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06946
chr15_64090212_G_A_b38	GTEx eQTL 2025	1.0	1.65743
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151782_1_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Regorafenib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166635
GSE180200,GSE180201_15_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FA-92-JL46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.328642
AB-12-PP61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255585
OC-10-FB51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284748
3054_FECH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.835132
GBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5025
GSE169356_0_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LC-12-VN85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.401773
SUM149PT	DepMap CRISPR Gene Dependency	1.0	2.43235
BB-74-RX30_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314185
GSE169155_5_v_4_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MT-ND2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54415
GSE141726,GSE141733_1_v_0_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135350_3_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE137325_2_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
protein metabolic process	GO Biological Process Annotations 2025	1.0	null
LD-69-TV81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234191
A549_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139684
GSE241701_2_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
11227_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.675729
9886_XAB2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.20874
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.941771
HT1376	DepMap CRISPR Gene Dependency	1.0	2.24528
PROX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9898
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.635309
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.11523
DA-85-SU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.508369
BE-66-UB12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.40521
PRMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3851
GSE246911,GSE246913_4_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain - Hypothalamus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.58916
MF-81-RJ18_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.304495
DF-45-GA42_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.370203
SMPD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.42702
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AE-64-IK64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.328479
GSE232631_4_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WEHI-231 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.55
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE137144_5_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CF-82-LL11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245306
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212161
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178255_5_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE179036_1_v_0_trim24_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.458632
GSE157555,GSE157556_4_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PB-18-HD85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.820035
CAKI2	DepMap CRISPR Gene Dependency	1.0	2.06369
SNU1544	DepMap CRISPR Gene Dependency	1.0	2.32439
PMC3022822-1471-2164-12-11-S10.XLS-Suppl_7_newLN229_SOX2_KO_MOCK_2-Unnamed_1_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210885_2_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FA-92-JL46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.362771
GSE232631_5_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MA-31-VM30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22803
K562_Cimetidine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178291
4950_MED27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.545519
KKU100	DepMap CRISPR Gene Dependency	1.0	2.46123
laminin-4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.692
GSE172146_2_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LF-94-HB11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.283896
YA-44-LW45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214806
K562_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222729
JOSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18185
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.35986
6851_PSMB3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.521316
DF-00-BX35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.374587
GSE217156_1_v_3_trpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0748
NC-27-AD53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.281908
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.6966
GSE201110_0_v_1_sirt4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_11_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-72-DZ30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.555854
Lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.811
GSE133087_1_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FC-85-OX77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202378
TSPAN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20555
TEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14182
GJC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44423
protein maturation	GO Biological Process Annotations 2025	1.0	null
BB-49-OQ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24733
ADAMTS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73106
TBCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02871
PMC9385264-NIHMS1828071-supplement-8.xlsx-AR-gene_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
LD-37-JE11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.668549
GSE193258,GSE193259_5_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OC314	DepMap CRISPR Gene Dependency	1.0	2.28487
MIXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.9684
GSE112761,GSE112767_2_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11263707-41419_2024_6896_MOESM4_ESM.pdf-17-ZNF367_ZNF367	Rummagene Transcription Factor Associations 2026	1.0	null
CB-31-UO16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300595
GSE87617_1_v_0_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212292
MM1S	DepMap CRISPR Gene Dependency	1.0	2.20729
GSE180200,GSE180201_2_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BC-54-ON71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.24841
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.560664
PMC12019336-41467_2025_58868_MOESM5_ESM.xlsx-Open_peaks_IKAROS_WT-Unnamed_5_IKZF1	Rummagene Transcription Factor Associations 2026	1.0	null
ZD-85-ND87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.608842
GSE149075_6_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CE-00-EK89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228774
VA-48-RJ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.32148
GSE162739_2_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7	DepMap CRISPR Gene Dependency	1.0	2.06269
PMC8410861-41467_2021_25544_MOESM32_ESM.xlsx-MCR-MCR_cells_-_DGE_iGCA_testis_vs_adult_testis_from_GSE112013_and_GSE124263_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6977700-aging-12-102667-s006..xlsx-Sheet1-The_identified_941_dysregulated_LmiRM-CTs_in_MI_using_traditional_method_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GB-73-QS80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259906
DD-30-SX80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.457727
GSE210101,GSE210114_0_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3526425-1471-2164-13-572-S3.xlsx-STAT6-Unnamed_1_STAT6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10769395-media-2.xlsx-S2E_EF_Activated_genes-Ebegboni_et_al_Supplemental_Table_S2E_Decreased_expression_following_depletion_of_EWSR1_FLI1_TC-32_TC-71_and_A673_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.111
GSE178255_2_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hydrogenosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.308
Nuclear replisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.88
NB-58-SA13_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.385551
AB-84-PK04_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265858
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE168797_4_v_6_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_AMG-900_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207902
ISX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7509
GSE102505_6_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.847
GSE182680,GSE182683_5_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.737458
GSE198434_1_v_0_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DB-41-IH69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.43638
496100402_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.38229
PUSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20232
HC-11-RK51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233803
Xeroderma pigmentosum group D	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.443
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.839743
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.675662
WF-96-ME07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.542762
GSE165704_0_v_1_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HC-01-FD24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.329824
EMX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.3891
GSE193258,GSE193259_9_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CD-47-YL43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.488449
GSE68155_1_v_0_gpr3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.497885
OF-37-IT01_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.41774
CA-42-YI34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.433032
GSE227592_8_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.724336
GSE221386_2_v_0_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE110524_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE90710_1_v_0_med13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Nilotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136627
GSE239578_0_v_6_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Alpha DNA polymerase:primase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.905
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE254770_0_v_1_sin3b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RAB11FIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.433
GSE82032_3_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HT144SKINFV1	DepMap CRISPR Gene Dependency	1.0	2.47887
GSE158197_5_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HUPT3_PANCREAS	CCLE Cell Line Proteomics	1.0	4.43746
COLO679_SKIN	CCLE Cell Line Proteomics	1.0	2.66133
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.867507
NARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13017
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5057
PMC4856960-supp_gkv1471_nar-01762-z-2015-File012.xlsx-GO_common_7H-HIF1_chip-Common_elements_in_chip7h_and_chip_hif1_2530_official_gene_symbols_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GA-43-FL03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322292
GSE109913_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE240386,GSE242143_1_v_4_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrial large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.519
QB-42-MC63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244384
TTC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78268
iron-sulfur cluster assembly	GO Biological Process Annotations 2023	1.0	null
HA1E	DepMap CRISPR Gene Dependency	1.0	2.51446
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.55362
2q11 2 copy number variation syndrome	WikiPathways Pathways 2024	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.608372
CASKI	DepMap CRISPR Gene Dependency	1.0	2.15498
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE154767_2_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CE-95-YX02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.461792
N syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.215
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5079
GSE130246_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
C32	DepMap CRISPR Gene Dependency	1.0	2.0887
GSE165647_2_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE207611,GSE207612_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.581202
Photosystem I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.415
DE-34-DT75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.472731
HSC3_UPPER_AERODIGESTIVE_TRACT	CCLE Cell Line Proteomics	1.0	3.09007
NC-01-ET52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.339593
PMC5404927-elife-24463-supp1.xlsx-1b_ERM_proteome-Gene_names_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE229070,GSE229071_0_v_2_sotorasib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Raltitrexed_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137009
Mianserin	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
PPP1R3E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11854
FF-54-JC89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.296281
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151494_1_v_9_nrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FA-65-UA27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22056
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.471454
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.562811
MCF7_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166042
ED-05-KX67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236516
GSE135514_2_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE160001,GSE160670_1_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE159678_6_v_7_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
QE-18-WG07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206878
JC-63-BE61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.508671
FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE179880_10_v_6_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CE-37-XI06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.45129
CCM2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00529
GSE164874_5_v_3_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE118766_2_v_0_ifng_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE215086_3_v_0_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
6024_PABPC1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.58323
GSE162739_8_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140607_1_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE246195,GSE246305_2_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.814131
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE225869_3_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DA-58-LZ09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268842
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.74464
Ikzf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.5824
K562_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186318
GSE196540,GSE196542_4_v_0_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE44157,GSE44163_3_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178255_1_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186223,GSE186224_6_v_3_hmces_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EMX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2416
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.1885
NPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47374
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_14_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Cells - Cultured fibroblasts	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.717172
GSE118077_1_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
EB-09-JJ93_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.596984
K562_SL-327_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018663
PRRX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7342
PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE227592_4_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GC-07-UO80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276895
FB-32-TL51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237007
NE-34-OZ69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.454235
WC-59-RG09_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276989
AC-36-SY22_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201208
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC3419980-leu201249x6.xls-RUNX1-DHS-1000bp-Unnamed_0_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE192771_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FZD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46424
SB-29-ZH97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226634
NCIH82	DepMap CRISPR Gene Dependency	1.0	2.12078
GSE190384,GSE190386_1_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MPPE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46304
Heart - Left Ventricle	GTEx Tissue Gene Expression Profiles 2023	1.0	1.98327
GSE233049_2_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE227634,GSE228381_0_v_7_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ME-54-JY76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.473572
GSE239578_0_v_4_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FB-39-CW59_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245679
GSE220520_3_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE224969,GSE224971_0_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SD-69-QA40_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.372651
BD-18-MM33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.299739
K562_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138191
K562_Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160413
protein maturation	GO Biological Process Annotations 2023	1.0	null
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE42805,GSE42811_1_v_0_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NECAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00243
GSE152699,GSE152723_3_v_2_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ESF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19049
GSE179880_10_v_13_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE115395_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
RA-49-ZB08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336149
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157383_6_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mitochondrial iron-sulfur cluster assembly complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.97
BB-74-RX30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.622476
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE199899_3_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9746818-jciinsight-7-152886-s077.pdf-10-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.00345
NQO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29608
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.83823
PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE116810_5_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
WD-62-UB45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.368717
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_0_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3807112-srep03041-s6.xls-GABPA-Gene_Symbol_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
CDC37L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68259
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205070_2_v_5_mertk_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LNCAPCLONEFGC_PROSTATE	CCLE Cell Line Proteomics	1.0	2.66133
S0-EE-XMXE_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201695
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.03677
GSE76425_0_v_3_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE102505_1_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
QF-71-QI30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.593933
PMC5013636-ncomms12601-s5.xlsx-LEF1-Groups_LEF1	Rummagene Transcription Factor Associations 2026	1.0	null
TD-69-UA90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.522901
RBM14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70435
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.859965
GSE102870_1_v_2_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Erythroid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.371
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10153265-media-3.xlsx-BENPORATH_NANOG_TARGETS_v2023_1-STANDARD_NAME_NANOG	Rummagene Transcription Factor Associations 2026	1.0	null
BA-60-RH02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209426
JF-30-FW92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23615
Hypogonadotropic hypogonadism 14 with or without anosmia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.609
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBTB25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0001
Atransferrinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
Autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.878
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214823,GSE214824_5_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_6_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZMYM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59889
MUTZ8	DepMap CRISPR Gene Dependency	1.0	2.23692
GSE154767_4_v_3_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MTHFD1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69258
Enhanceosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.77
PMC12019345-41598_2025_98989_MOESM10_ESM.xlsx-Sheet_1-CCNE2_related_genes_AND_HNSCC_HNSCC_DDP_NOT_DDR_Genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
PDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9448
FOXA1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
JA-62-XU82_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317073
Apoptosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.268
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.31353
K562_Cyclocytidine HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157707
HF-91-IU60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.283716
GB-73-QS80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.477252
GSE149880_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PD-94-WO47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217463
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MT-ND6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6415
USHBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11788
496100595_PCx_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.11997
SW948	DepMap CRISPR Gene Dependency	1.0	2.11344
Paliperidone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.4
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.423086
GSE144120_3_v_1_plcg2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF584	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49758
GSE201042_6_v_1_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BE-92-TW08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208358
SP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25111
GSE129287_0_v_1_cd200_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178267_2_v_0_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FA-43-XS35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282885
GSE172295_3_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.709192
PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-DMOG_-_HIF1A-gene_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
A549_M344_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132196
SHROOM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31424
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.29663
GSE142210_2_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GC-57-HV87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334216
GSE125862_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12381255-41389_2025_576_MOESM3_ESM.xlsx-Differentiated_SRCAP-1879-Gene_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
BPH1	DepMap CRISPR Gene Dependency	1.0	2.21974
GSE186620_0_v_1_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5744
GSE199204,GSE211619_4_v_2_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RNASE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11615
GSE126463_0_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BF-49-QA17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219938
GSE147662_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DE-99-OT37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.530773
GB-96-WX99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.45264
GSE126621,GSE126920_1_v_3_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE181003_1_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH522_LUNG	CCLE Cell Line Proteomics	1.0	5.38116
GSE182680,GSE182683_7_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.137
HT144SKINFV2	DepMap CRISPR Gene Dependency	1.0	2.37156
GE-25-DQ65_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.438709
PMC12087453-giaf039_giga-d-24-00597_revision_1.pdf-6-HOXC8_HOXC8	Rummagene Transcription Factor Associations 2026	1.0	null
GSE248858_1_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AE-39-DG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.763682
NR6A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0765
CNOT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36114
8109_SLC7A6OS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.559746
GSE182680,GSE182683_10_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.488648
AB-00-IL62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.353853
Photosystem	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.134
PMC12354803-42003_2025_8643_MOESM2_ESM.xlsx-2w_TP63_positive-Gene_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
GSE227592_2_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.975281
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
ZNF423	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00138
WDCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24692
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211215_1_v_0_akr1b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE143994_2_v_3_ythdf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
OA-15-DB28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330244
TBX15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26995
AF-00-QK19_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.34412
6708_PPWD1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.649081
GSE197571_3_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_7_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.999066
XB-75-YN01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.483535
AA-48-XT80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26059
BC-62-RZ55_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284882
PMC4149371-pone.0105180.s010.xls-SOX2-GENE_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
RAB3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03139
WB-82-EL69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265624
HE-80-BQ08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.616986
GSE107505_1_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE218727_0_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.540758
GSE149903_5_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Thylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.05
GSE182680,GSE182683_10_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BB-77-QQ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.91324
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.9192
GSE140607_0_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MYBL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1898
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3807112-srep03041-s6.xls-ELK4-Gene_Symbol_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
GABPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85292
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204939
PMC5637904-PATH-243-193-s016.xlsx-human_down_in_fat_SOX11-Unnamed_6_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
GSE223287,GSE223290_2_v_4_braf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193999,GSE194000_4_v_0_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-28-GJ71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.466084
GSE119978,GSE180930_2_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYOZ3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04448
GSE140936,GSE140938_2_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.312852
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.79424
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242488
ZNF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.5426
Muscular coat	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.919
PMC7617064-EMS151900-supplement-Extended_Data_Figure_7_Source_Data.xlsx-D23_RORC-Logfold_change_threshold_1_0_1_RORC	Rummagene Transcription Factor Associations 2026	1.0	null
VD-76-SO91_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211357
MAP2K1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11689
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.574475
GSE93309_5_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.599667
GSE160817_3_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
1544_CHAF1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.521129
NDUFB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44894
GSE155305_2_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TIPARP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03218
GSE178255_1_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Lenalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140175
GSE127970_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Multiple mitochondrial dysfunctions syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.654
GC-69-JF03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.293963
CD-26-MB82_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263958
GSE119978,GSE180930_3_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5637904-PATH-243-193-s016.xlsx-human_down_in_fat_SOX11-Unnamed_7_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.848688
GSE181513_2_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157904_3_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE137144_4_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205070_2_v_9_mertk_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH1573	DepMap CRISPR Gene Dependency	1.0	2.37071
GSE182680,GSE182683_7_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_10_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE181966_5_v_3_has2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CB-11-GB40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.349962
EFHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62874
EB-09-JJ93_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.42665
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE225647_1_v_3_srsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120612_7_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE113952,GSE113953_1_v_0_chtop_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223691
GSE197948_2_v_0_atp7b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205291,GSE205292_1_v_3_drd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE121866_0_v_3_six4_human	RummaGEO Gene Perturbation Signatures	1.0	null
NC-27-AD53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.791322
Trachea	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC8851354-Table_5.xlsx-Ruxolitinib_reg_FD-bound-Supplementary_Table_5_Genes_regulated_by_ruxolitinib_that_are_FUS-DDIT3_targets_in_MLS_402-91_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
MSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.3626
AA-86-YY62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.327585
GSE214823,GSE214824_0_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9529122-pone.0274785.s002.xlsx-S1_Table-S1A_Table_Differentially_expressed_genes_in_HeyA8_overexpressin_ZNF521_vs_HeyA8_control_cells_ZNF521	Rummagene Transcription Factor Associations 2026	1.0	null
GSE173911,GSE173917_0_v_1_morc3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FF-86-NH56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.408936
GSE114992,GSE114993_0_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EF-99-HJ48_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.329327
BA-19-VU85_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256344
PPP2R2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0007
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Gene_Name_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
HF-00-QG19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219947
Lung epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.774
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.509337
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE62843,GSE64370_0_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE203584_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.9967
GSE174498,GSE174500_0_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bronchial epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
CC-18-YW57_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.576241
SW1990_PANCREAS	CCLE Cell Line Proteomics	1.0	2.19454
Adipose tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.237
GSE169152_3_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CA-42-YI34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.53887
GSE130956_0_v_1_icaritin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SF3A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0863
4926_MEAF6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.589532
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.31988
RAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2915
ZBED1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1985
AC-28-RT00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.290184
B-lymphoblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.862
Lhx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.2533
PMC4060771-170289.f1.pdf-324-TCF21_TCF21	Rummagene Transcription Factor Associations 2026	1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.723514
SOX14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15077
WD-26-EB85_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.386711
GSE225869_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE102870_3_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
7795_SERF2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.530038
GSE193258,GSE193259_5_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NC-52-AG88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.324674
Rarg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	48.3244
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.517968
AC-84-QG99_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259952
TD-69-UA90_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.29764
Hypochromic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.21
GSE224763_1_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CA-68-TC79_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220558
ZKSCAN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21098
GSE195582_0_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6879454-Data_Sheet_1.xlsx-AA_in_vitro-Unnamed_4_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
GA-77-MH38_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.412815
H4C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40948
C99	DepMap CRISPR Gene Dependency	1.0	2.23235
GSE97278,GSE97280_2_v_1_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2257
GSE162739_6_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OC-71-BZ81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265357
BB-55-JH29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204675
BF-00-PE90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.420718
GSE133683_1_v_5_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
LB1047RCC	DepMap CRISPR Gene Dependency	1.0	2.1869
BHLHE40	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3484
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160817_2_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OCIMY5	DepMap CRISPR Gene Dependency	1.0	2.0061
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_5_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238965
GSE206226_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10864182-41588_2023_1596_MOESM4_ESM.xlsx-ST12_Significant_Genes_combine-Unnamed_1_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
RKO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.81
GSE158100,GSE158101_1_v_0_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE221327_5_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE230174_0_v_1_glycerol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE134029_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12375500-41388_2025_3449_MOESM1_ESM.xlsx-DBP_down-gene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.205
Respiratory epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
CELSR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06906
MEGF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71248
K562_Cediranib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140461
GSE172020_0_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EF-80-OD07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207081
BC-26-LE04_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.342621
A549_Prednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169586
PMC8755441-mmc3.xlsx-IRF7-Up-ezh2_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE144838_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3807112-srep03041-s6.xls-E2F1-Gene_Symbol_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PB-40-YB26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.376334
K562_Fluorouracil_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164138
USF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1342
A549_Hesperadin_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161453
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Spleen	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.419
GSE159728,GSE159730_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FD-29-MM50_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314394
JF-84-QZ64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.388159
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GA-04-JM33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277126
GSE232631_0_v_2_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193993_0_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233679_14_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PB-40-YB26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28915
9587_UMPS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.614434
GSE119978,GSE180930_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE107505_0_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CF-97-KZ12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.44754
H3C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01612
GSE182680,GSE182683_7_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC1500_BREAST	CCLE Cell Line Proteomics	1.0	2.15891
OB-17-DQ74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.336028
UMUC13	DepMap CRISPR Gene Dependency	1.0	2.15924
S0-EE-XMWH_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.427124
KCNH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72043
KYSE70_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	3.28506
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228277
FF-86-NH56_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250004
GSE158834_7_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bronchial epithelial cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
2121_DDX42_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.615283
KAT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28315
GSE169697,GSE169725_1_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GC-74-QF56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244882
GSE196407_1_v_0_fluorouracil_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE185944_2_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
P4E6	DepMap CRISPR Gene Dependency	1.0	2.36539
CXCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70988
NUP160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40915
ANKRD24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0869
KIF21A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25343
DNAJB12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05541
GSE89767_2_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OD-96-OP94_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.377032
DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0937
TLX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9094
GPR50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47593
HOMEZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01814
GSE131660_1_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114013,GSE114014_0_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SPTBN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20678
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.0499
metallo-sulfur cluster assembly	GO Biological Process Annotations 2023	1.0	null
CB-11-GB40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.319769
GSE158456_2_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DB-73-BC12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.373981
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.60632
QA-07-KC40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.366341
DUX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3267
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
PMC11908325-media-2.xlsx-Table10_MR-Unnamed_7_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
9469_TYW3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.548679
AE-13-CX28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.277099
HC-63-SV27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236809
MPI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13402
XC-13-LW13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.456444
BC-72-DZ30_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237033
DC-02-OP01_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28559
STAT5A-24692510-EPITHELIUM-MOUSE-MAMMARY	ChEA Transcription Factor Targets 2022	1.0	null
JVE015	DepMap CRISPR Gene Dependency	1.0	2.17692
Multiple mitochondrial dysfunctions syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.338
SOX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5334
GSE171177,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11908325-media-2.xlsx-Table10_MR-Unnamed_6_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11655728-12672_2024_1562_MOESM2_ESM.xlsx-Sheet1-Hs_ESC_NANOG_targets_Boyer_NANOG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE100316_7_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.6234
ZMIZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13216
LBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.9774
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.43278
GSE169697,GSE169725_0_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
LS180_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	5.85817
AA-43-BW50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210943
GLI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00415
GSE185944_2_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE127790_10_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.391704
K562_Ofloxacin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017174
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.79666
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
BD-18-MM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.53559
Ankle joint	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.816
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE147943_2_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CAL33_UPPER_AERODIGESTIVE_TRACT	CCLE Cell Line Proteomics	1.0	3.14261
GSE153836_14_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE225869_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SRY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.6786
GSE211151_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.605692
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CE-24-LQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307116
IE-80-DC24_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226844
GSE225869_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Photosynthetic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.086
GSE112761,GSE112767_2_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YA-34-DT48_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261016
SPATA33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2028
GSE146074_10_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE225901_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE179974_3_v_4_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FC-64-QJ96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.343388
FF-90-JK74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.410415
Microglial cell_Embryonic prefrontal cortex_Human	CellMarker Gene-Cell Type Associations	1.0	null
KYSE450_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	2.50906
GSE149943_1_v_3_cd8a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178255_2_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174735_1_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAPKBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11254
PMC4266008-mmc3.xlsx-iPS-MSC_vs_MSC-Unnamed_1_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193900,GSE193905_1_v_0_pura_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169356_0_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.47928
GSE236486_1_v_2_arnt_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199874_4_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SOX12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.4452
PMC11665559-jciinsight-9-183889-s131.xlsx-Fig2DiffBind_MYB_TR-PLEvsNTC-WT-Nearest_Ensembl_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE75976_3_v_4_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GE-63-WI86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307782
AF-01-FE42_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239057
GSE199255,GSE199356_3_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE90019,GSE90020_5_v_2_phf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CA-68-TC79_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231544
GSE182680,GSE182683_10_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE122101,GSE122103_3_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE262134_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5556
GSE193258,GSE193259_5_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11655728-12672_2024_1562_MOESM2_ESM.xlsx-Sheet1-Hs_ESC_SOX2_targets_Boyer_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE212299_3_v_0_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EDARADD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35174
GSE193177_1_v_0_st266_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE252857_2_v_0_prednisone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE126463_1_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.05713
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.7241
GSE110440_1_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5361605__F4	PFOCR Pathway Figure Associations 2023	1.0	null
A549_Alendronate sodium trihydrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143775
CE-18-CG29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.49076
GSE81803,GSE81912_0_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE240896,GSE240899_2_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE179880_1_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MICOS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.909
GSE137144_3_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.31175
HC-18-NB46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240074
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EE-98-PF86_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.343398
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Nearest_Ensembl_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10244410-41467_2023_39054_MOESM5_ESM.xlsx-PIE-LIN28B-GeneSymbol_LIN28B	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9746818-jciinsight-7-152886-s077.pdf-10-ENSG00000141510_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
PRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10499
ID3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46592
AE-67-FF84_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.72862
CC-18-YW57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292656
GSE129244_3_v_1_lmo2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BA-69-TQ80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297539
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6131
PMC5013636-ncomms12601-s5.xlsx-ETS2-Groups_ETS2	Rummagene Transcription Factor Associations 2026	1.0	null
MED11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38016
GSE73562,GSE73563_1_v_2_preb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0277899
SEMA4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.078
E2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.317
Electric organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.252
PMC10153265-media-3.xlsx-BENPORATH_SOX2_TARGETS_v2023_1-STANDARD_NAME_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
iron-sulfur cluster assembly complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.329
AD-30-OK99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25692
DE-73-JX23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.423215
GSE158715_2_v_4_cyp1b1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182727_1_v_0_busulfan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.460373
GSE240439_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE100316_7_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BF-29-LU75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.306924
HB-24-GP45_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230556
PMC12087453-giaf039_giga-d-24-00597_original_submission.pdf-5-HOXC8_HOXC8	Rummagene Transcription Factor Associations 2026	1.0	null
Torasemide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.27
Multiple mitochondrial dysfunctions syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.307
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE211215_1_v_0_pemetrexed_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nr1h2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.4809
GSE211224_2_v_0_donepezil_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AF-12-IW93_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322347
SYT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14044
Epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
GSE255432_7_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
OE-31-YC41_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.341989
PF-39-DY68_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.751887
PMC12019336-41467_2025_58868_MOESM5_ESM.xlsx-Open_peaks_IKAROS_WT-Unnamed_11_IKZF1	Rummagene Transcription Factor Associations 2026	1.0	null
RORC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8036
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9235
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.94673
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-9.0081
GSE163862_0_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4860404-Table1.XLSX-MR_specific-Table_S1-9_DEGspecific_for_mouse_rat_SCI_at_1_dpi_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178255_1_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYBBP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29082
GSE158456_1_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Metallochaperone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.505
ZNF341	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7309
RASA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33223
JUN::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3883
3-Benzyloxyaniline	DeepCoverMOA Drug Mechanisms of Action	1.0	0.21
Organellar large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.513
3-isopropylmalate dehydratase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.366
Nuclear replication fork	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.858
GSE232558_0_v_1_fbxl12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5339
A549_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150515
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.435742
ND-48-XK57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202713
DGKE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35376
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.31186
BE-27-RQ61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.495491
IA-27-CK10_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.497188
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
iron-sulfur cluster transfer complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.004
CCIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22591
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.407756
GSE210885_2_v_4_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GC-04-UF36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209907
K562_Fasudil_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168458
GSE224294_3_v_2_ngly1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.76269
FC-64-QJ96_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238405
GSE126463_5_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.513407
A375_SKIN	CCLE Cell Line Proteomics	1.0	3.09728
GSE151612_0_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE114013,GSE114014_0_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254596
GSE137653_4_v_0_siglecf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4149371-pone.0105180.s010.xls-NANOG-GENE_NANOG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE228181_3_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.723312
COA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19442
CA-42-YI34_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.588609
ALX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.043
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	1.0	3.13965
GSE147943_7_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BE-38-UW72_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.58173
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.6624
GSE228181_3_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CB-46-FO63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.611351
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-61-BE07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.349865
BCL7C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61943
EF-80-OD07_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238055
GSE184479_3_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JC-63-BE61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216411
PSMB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30665
PMC3226433-1756-8935-4-20-S1.XLS-Table_S5_Miz-1_KD_gene_exp_chan-Genes_up-regulated_in_Miz-1_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE240439_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ANKRD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12006
AA-23-FM46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.637608
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE164874_5_v_0_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE207863_0_v_1_hdac5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10864182-41588_2023_1596_MOESM4_ESM.xlsx-ST12_Significant_Genes_combine-Supplementary_Table_12_Genes_prioritisation_combining_FUMA_MAGMA_Hi-C_MAGMA_and_TWAS_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
Gastrointestinal stromal tumor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.469
DA-17-XI26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307924
BE-82-TS38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.620033
UC-00-QA88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.326545
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.67533
CF-50-QK79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.376496
GSE135352_6_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_5_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE239578_1_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE154767_2_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5474565-onc2016488x2.xlsx-Table_S4_MLL_Target_Genes-MV4-11_MLL-AF4_target_genes_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
HA-42-TE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21921
K562_Ramelteon_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159715
MCF7_PFI-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160263
XE-29-LT20_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250071
TE-15-RO34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.787729
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.119
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.15136
GD-46-OD81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.347836
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.0723
Mecom	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.963
PMC10055234-media-3.xlsx-ZCCHC17_KD_DSGs_637-Unnamed_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE132948,GSE132949_4_v_5_msi2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BF-00-PE90_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274788
AB-97-BI36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.388015
OB-15-UL37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257586
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.744213
BATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7985
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4003
GSE151782_2_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AC-36-SY22_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.708944
Colitis	DisGeNET Gene-Disease Associations	1.0	null
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3148
EBAG9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4459
GSE216538_7_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Endosome lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.555
AF-80-GK24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243895
GSE226259_0_v_1_scd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FA-92-JL46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202855
GB-01-UN23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.293526
HD-62-KE69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.351909
PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-Normal_309_TCF7_rep1_sorted_pea-Gene_Name_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.72212
A549_Momelotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0105636
GCFC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25355
AA-22-UI44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.962979
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE150557_1_v_0_dnmt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
B-lymphoblastoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.811
K562_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168394
PMC8799469-41591_2021_1576_MOESM8_ESM.xlsx-Fig2e_-_E2F4_808g-SCENIC-predicted_targetome_for_E2F4_808g_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
PHAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43437
GSE192771_2_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NB10	DepMap CRISPR Gene Dependency	1.0	2.23013
GSE226285_3_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-71-CI37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.800596
VC-19-YG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263749
GSE193993_1_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.443093
BE-38-UW72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.540482
K562_SRT2104_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177862
BD-96-HO33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259431
K562_Fedratinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153379
AB-70-GR31_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252745
GSE248858_4_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.28367
Nkx3-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2909
GSE202434,GSE202438_15_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PA-15-CP52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246329
FKBP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67997
L-cysteine desulfurase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.262
GSE196962_2_v_1_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE75976_3_v_9_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147283_1_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6977700-aging-12-102667-s004..xlsx-Stage1-The_identified_3126_dysregulated_LmiRM-CTs_in_stage_1_of_MI_1_day_of_MI_using_our_method_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.35259
RBM17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18719
496100620_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.53459
GSE241701_4_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE220520_6_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
OC-71-BZ81_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291144
GSE226285_3_v_1_nr0b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.216
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.17262
GSE252857_2_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BATF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4713
GSE142210_9_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
5165_MPHOSPH8_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.519652
FB-29-KC76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.445047
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE230174_0_v_1_dagla_human	RummaGEO Gene Perturbation Signatures	1.0	null
CE-95-YX02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.830465
AA-58-FJ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301658
ZNF184	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.6096
GMPR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23683
GSE180575_1_v_0_fmo5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205729,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.74754
PDCD2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55887
DC-43-KF54_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258672
SLC27A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07179
GSE205729,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-86-YY62_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.338097
AF-00-QK19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.960579
PDCD6IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36578
BE-81-QL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.488674
PMC11399095-44161_2024_532_MOESM7_ESM.xlsx-Sheet1-Supplementary_Table_6_DEG_of_hyperexpanded_clones_in_EAT_vs_AA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
8040_SLC35A4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.924779
Alveolar macrophage cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.541
GSE126463_4_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE217541,GSE217543_0_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BB-20-UU03_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258969
GB-84-KP45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263606
GSE162739_4_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.06793
CE-18-CG29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236882
K562_MK-0752_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015985
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.929497
Respiratory chain complex I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.819
PMC6357748-aau9223_Table_S1.xlsx-CD4_T_-_LPS-Unnamed_0_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE76771_1_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210885_5_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.630207
4946_MED23_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.562974
106_ACTL6A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.563588
GXYLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22282
GSE126463_1_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.95491
KC-17-YN77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292493
JC-63-DO70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215732
AE-11-VB80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279788
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.715992
RA-49-ZB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.412531
GSE188870,GSE188871_1_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.18737
CHLA266	DepMap CRISPR Gene Dependency	1.0	2.15212
EC-07-AO30_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345937
FAM174C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2481
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.41589
GSE199189_1_v_0_creld2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140092_0_v_1_socs3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.639957
GSE208254_4_v_5_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE183251_4_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-58-LZ09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240391
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149124,GSE149128_3_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232982
GSE120248,GSE120252_1_v_0_macf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149880_2_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE160001,GSE160670_3_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.384327
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.499155
UF-06-JB00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.457726
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.10758
DC-43-KF54_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.547805
PMC4860404-Table1.XLSX-MR_unique-Table_S1-7_DEG_unique_in_mouse_and_rat_SCI_at_1_dpi_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.603693
GSE138938_1_v_4_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_S-Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198206
GSE159446,GSE159449_1_v_0_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE215086_3_v_6_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
UA-39-TN76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278028
GSE127790_9_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TJP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95041
GSE178255_5_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FD-20-OG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.879562
AE-39-DG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.535002
KLHL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04805
PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE140965_2_v_3_mybpc3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110178_1_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE140092_2_v_1_socs3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE215155_0_v_1_golph3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MB-32-LQ97_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262382
GC-46-AX49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297905
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.383727
K562_ENMD-2076 L-Tartaric acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149526
GSE126463_6_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
LD-69-ZV56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.349109
GSE168797_2_v_3_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_7_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HF-00-QG19_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266091
AF-42-MP86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.5413
GSE209898,GSE209899_0_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
WDR13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18347
AC-44-UR36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.333794
PMC7933708-mmc2.xlsx-DNMT-target_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Thiotepa_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174257
RFX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.305
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.72276
GSE221327_4_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.99
GSE218819_2_v_1_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
AB-04-NN16_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269147
PMC8851354-Table_6.xlsx-STAT3-bound_genes_GM12878-Supplementary_Table_6_STAT3-bound_unique_genes_in_GM12878_cells_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
BAZ2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38387
GSE160817_5_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SFR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78699
SNX33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11336
RAD50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16394
COX14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26618
GSE110440_2_v_3_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MIM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.643
Organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE171837_0_v_3_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GB-84-KP45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.511029
RAB31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26442
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.683175
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_4_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12103066-FEBS-292-2688-s001.pdf-89-RUNX1_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4595011-pgen.1005555.s003.xlsx-BPTF_DOWN-regulated-Gene_name_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_7_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nobox	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.0526
GSE201381_0_v_1_bhlhe22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DB-41-IH69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.51436
GSE206226_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5263239-mmc2.xls-MV4_11_-_MLL-AF4-Non-spreading_targets_gene_names_1985_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.317609
K562_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148891
Gastrointestinal stromal tumor	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.517
FF-22-NB12_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287134
A549_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016435
5703_NLK_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.608359
SELENBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2134
GRAMD1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.47543
TFEC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4814
GSE146894_3_v_8_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UA-39-TN76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.446705
PC-87-OG75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212196
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
SLC35A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19878
GSE121198,GSE129779_0_v_1_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
ORC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25739
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BATF::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5832
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.45884
GSE162739_7_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142019,GSE142021_10_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201668_0_v_1_ncor2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Granulocyte-monocyte progenitor_Umbilical cord blood_Human	CellMarker Gene-Cell Type Associations	1.0	null
Mitochondrial outer membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.973
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AE-85-KE62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.673225
BC-84-BQ58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206131
CCNYL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14312