association dataset threshold value standardized value GTEX-QLQW-0426-SM-447A7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.95466 STAT4 MotifMap Predicted Transcription Factor Targets 1.0 null cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-1012-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ECH1 Pathway Commons Protein-Protein Interactions 1.0 null Inner nuclear layer TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.08 Adenocarcinoma DisGeNET Gene-Disease Associations 1.0 null GSE57871_6_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null internal segment of globus pallidus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23452 myofibril COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.541117 including GeneRIF Biological Term Annotations 1.0 null GSE131649_6_v_8_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WFJO-0826-SM-4LVM5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02057 GTEX-TSE9-2926-SM-3DB77 GTEx Tissue Sample Gene Expression Profiles 1.0 0.984412 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5117-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Alimentary canal TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 proton-transporting two-sector ATPase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.965 ARPC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60528 GSE207514,GSE207515_2_v_3_acetylcysteine_human RummaGEO Drug Perturbation Signatures -1.0 null liver_d HPA Tissue Sample Gene Expression Profiles -1.0 -1.16949 CRCGN010_HEPG2_24H:P05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.4434 SIN3A_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE210101,GSE210114_2_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null VIIAt Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.993304 GSE182680,GSE182683_7_v_2_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GSE147876,GSE147877_4_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN016_MCF10A.TP53.M_24H:K06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.81717 cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.34632 REST_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M9-01A-23R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TMEM250 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06455 NAA15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07755 CRCGN017_MCF10A.WT.HP_24H:L22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.05015 496100611_FWM_no dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.29344 myxedema DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.795002 PMC10140619-mmc5.xlsx-Beta3_ConVsBSL-Gene_BHLHE22 Rummagene Transcription Factor Associations 2026 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A6S6-01A-21R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A-CA-04-2009(H1N1)_24Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.31863 PEBP1 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN011_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.7136 GTEX-RN64-1026-SM-48FDX GTEx Tissue Sample Gene Expression Profiles 1.0 0.856689 GSE134375_0_v_5_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null V, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.854559 20436685-ST6-1 GeneSigDB Published Gene Signatures 1.0 null GTEX-XUZC-1426-SM-4BRV3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.93982 GBA Pathway Commons Protein-Protein Interactions 1.0 null AIFM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06076 ETV2::HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.3061 blast cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.069996 Lymphocyte TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.033 FOXL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.4423 CKB Pathway Commons Protein-Protein Interactions 1.0 null phosphagen biosynthetic process GO Biological Process Annotations 2023 1.0 null GSE114284_4_v_3_irf1_human RummaGEO Gene Perturbation Signatures -1.0 null OVMIU COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE114284_1_v_5_irf1_human RummaGEO Gene Perturbation Signatures -1.0 null PMC10140619-mmc5.xlsx-Rank_Beta1-Beta3-Gene_BHLHE22 Rummagene Transcription Factor Associations 2026 1.0 null Slow twitch muscle fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.899 anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.918534 CRCGN015_MCF10A_48H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.73057 U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.09687 VZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.947166 Large intestine TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02215 PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-Fay_Heat_LPStoThermoneutral_LPS-Gene_Symbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null KP4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1565 18667080-TableS9 GeneSigDB Published Gene Signatures 1.0 null STAT3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.6608 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 MDM2 Pathway Commons Protein-Protein Interactions 1.0 null embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.411631 GSE126463_1_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null Central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE168587,GSE168752_3_v_1_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-97-8176-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A.TP53.M_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.30515 CRCGN014_HEPG2_3H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.44965 X Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.13437 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7263-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RARA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 49.6399 IV, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.35119 CPC-N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.81005 GSE235587_2_v_0_mitoxantrone_human RummaGEO Drug Perturbation Signatures 1.0 null intracellular non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.24424 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7060-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Midbrain TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.598 body of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.05439 Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-7018-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.60456 anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.963506 Limbic system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 atrophic muscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.878605 CTCF_GM13976_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE126463_5_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null letrozole_homo sapiens_gpl3921_gse33366 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-QVUS-0011-R3A-SM-3GAFD GTEx Tissue Sample Gene Expression Profiles 1.0 1.00757 PSMA5 Pathway Commons Protein-Protein Interactions 1.0 null AA-22-UI44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.351626 MDA-MB-231 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.859092 APOD Pathway Commons Protein-Protein Interactions 1.0 null GSE147876,GSE147877_2_v_9_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null 18667080-TableS2 GeneSigDB Published Gene Signatures 1.0 null organelle LOCATE Curated Protein Localization Annotations 1.0 null EMD Pathway Commons Protein-Protein Interactions 1.0 null GTEX-S4UY-0826-SM-4AD4Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.878087 rh30 HPA Cell Line Gene Expression Profiles -1.0 -1.28527 bc3h1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.437205 DNTTIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27811 GTEX-TKQ2-1326-SM-4DXT9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.983987 CAL-120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11497 Preadipocyte cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.733 GSE203060_0_v_2_kdm4c_human RummaGEO Gene Perturbation Signatures -1.0 null SLC25A3 Pathway Commons Protein-Protein Interactions 1.0 null GSE175787_4_v_6_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null GSE238005_5_v_3_c9orf72_human RummaGEO Gene Perturbation Signatures 1.0 null MYC ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2771-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ASB9 Pathway Commons Protein-Protein Interactions 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-77-8148-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.14393 brain cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063192 CMBL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.50505 496100330_PCx_possible Alzheimer's disease_no TBI_100+_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.48874 nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041329 substantia nigra, compact part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.943273 H3255 COSMIC Cell Line Gene CNV Profiles -1.0 -3.83684 Internal female genital organ TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.017 Null cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.033 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OZ-01A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Fast twitch muscle fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.536 GSE210101,GSE210114_1_v_10_urod_human RummaGEO Gene Perturbation Signatures -1.0 null IV, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.08981 stomach smooth muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.345188 AA-23-FM46_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.342798 GSE158969_1_v_2_trastuzumab_human RummaGEO Drug Perturbation Signatures -1.0 null VDR ChEA Transcription Factor Targets 1.0 null SLC5A3 Pathway Commons Protein-Protein Interactions 1.0 null Cerebral creatine deficiency syndrome 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.29 mediodorsal nucleus of thalamus_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.09408 decitabine_homo sapiens_gpl570_gse30985 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FOXP1 ChEA Transcription Factor Targets 1.0 null UBE2V1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-R55G-1226-SM-48FDC GTEx Tissue Sample Gene Expression Profiles 1.0 0.986762 Reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.1 SQRDL Pathway Commons Protein-Protein Interactions 1.0 null ANKLE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00825 GTEX-XUJ4-2026-SM-4BOOW GTEx Tissue Sample Gene Expression Profiles 1.0 1.1464 GNAI1 Pathway Commons Protein-Protein Interactions 1.0 null PMC4498179-srep11671-s1.pdf-234-POU6F2_POU6F2 Rummagene Transcription Factor Associations 2026 1.0 null NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.3253 Colorectal Carcinoma DisGeNET Gene-Disease Associations 1.0 null HIF1A_01_224 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 0.97213 501A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.837369 GSE210101,GSE210114_8_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null extracellular region COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Colon - Transverse GTEx Tissue Gene Expression Profiles 2023 1.0 2.17117 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7416-11A-01R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QEL4-1426-SM-447AC GTEx Tissue Sample Gene Expression Profiles 1.0 0.876783 FOXA2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.8387 non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.24424 prostate GeneRIF Biological Term Annotations 1.0 null system GeneRIF Biological Term Annotations 1.0 null GSE216273,GSE216292_14_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE201309_5_v_7_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null HOXA5_01_305 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.58593 GSE125862_2_v_0_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GA-94-MC54_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.235709 ZNF382 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.5955 GSE163240_2_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null ACTB Pathway Commons Protein-Protein Interactions 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6956-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTSG Pathway Commons Protein-Protein Interactions 1.0 null CRCGN016_MCF10A.WT.HP_24H:K06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.82166 Brain stem TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 DCD Pathway Commons Protein-Protein Interactions 1.0 null GSE202434,GSE202438_12_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7688-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAB3GAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32999 GSE123861_1_v_0_sin3a_human RummaGEO Gene Perturbation Signatures -1.0 null CAMK2N2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76913 Mitochondrial respiratory chain complex I COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.675 classical GeneRIF Biological Term Annotations 1.0 null GTEX-XOTO-0011-R11B-SM-4B64O GTEx Tissue Sample Gene Expression Profiles 1.0 1.0039 Cerebral creatine deficiency syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.079 electrocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.05721 red nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.992761 PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1c-List_of_1682_genes_differentially_regulated_by_GLI1_FDR_0_1_GLI1 Rummagene Transcription Factor Associations 2026 1.0 null HNRNPA2B1 Pathway Commons Protein-Protein Interactions 1.0 null cardiovascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.22158 HS 936.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17066 thigh TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.179278 496100474_FWM_possible Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.16116 PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_2_MITF Rummagene Transcription Factor Associations 2026 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A6C6-01A-21R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08948 Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.378 muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.69251 GSE210101,GSE210114_1_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null colorectum TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null male reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.243294 KYSE-140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08948 abnormal startle reflex MPO Gene-Phenotype Associations 1.0 null cytosol COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.676803 abnormal learning/memory/conditioning MPO Gene-Phenotype Associations 1.0 null CRCGN015_MCF10A.TP53.M_24H:H19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3332 mitochondrion COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.799728 Lung adenocarcinoma_LUAD_TCGA-78-7153-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EE-03-SG02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.333642 GSE192860_0_v_1_trifluoperazine_human RummaGEO Drug Perturbation Signatures -1.0 null carbohydrate metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.064449 SLC30A7 Pathway Commons Protein-Protein Interactions 1.0 null SH3BGRL2 Pathway Commons Protein-Protein Interactions 1.0 null inner portion of lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00409 HUH-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.73748 organelle inner membrane GO Cellular Component Annotations 2023 1.0 null seminal vesicle HPA Tissue Protein Expression Profiles -1.0 -1.3208 Lung adenocarcinoma_LUAD_TCGA-64-1680-01A-02R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC6932815-ppat.1007634.s014.xlsx-ST4_DGE_ELF1-R8AvIFN6-mock_lfc2-ensembl_gene_id_ELF1 Rummagene Transcription Factor Associations 2026 1.0 null PMC11392782-Table1.xlsx-Table_S6-Supplementary_Table_6_MR_and_colocalization_results_of_mitochondrial-related_plasma_protein_on_T2DM_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QMR6-1326-SM-32PLB GTEx Tissue Sample Gene Expression Profiles 1.0 0.983249 CRCGN015_MCF10A.TP53.M_24H:I18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1176 cerebellum_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.827403 LOX Pathway Commons Protein-Protein Interactions 1.0 null metencephalon TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null LHX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.7699 mitochondrial membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.383895 Uterine Carcinosarcoma_UCS_TCGA-N6-A4VD-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8015-01B-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H920 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11497 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IF-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HESX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.6822 NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17742 GSE133516_5_v_3_kat7_human RummaGEO Gene Perturbation Signatures -1.0 null RXRA ENCODE Transcription Factor Targets 1.0 null Photosystem II oxygen evolving complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.577 CRCGN015_MCF10A.TP53.M_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.7895 intestine TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null central nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.943075 corpus callosum Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -3.30987 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5365-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null viscus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null amygdaloid complex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.5606 FH Pathway Commons Protein-Protein Interactions 1.0 null brain cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.078586 organelle membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 MYO1C Pathway Commons Protein-Protein Interactions 1.0 null GTEX-T5JC-0011-R8A-SM-32PLM GTEx Tissue Sample Gene Expression Profiles 1.0 0.906811 permeability GeneRIF Biological Term Annotations 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MF-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2822-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QMR6-0011-R11A-SM-32PKK GTEx Tissue Sample Gene Expression Profiles 1.0 0.929739 JUND_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsf1_19179333_rko_colon_carcinoma_lof_human_gpl6244_gse12762 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.980379 LGALS3BP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13855 endometrial disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.298731 TWF2 Pathway Commons Protein-Protein Interactions 1.0 null u266 HPA Cell Line Gene Expression Profiles -1.0 -1.28527 Small intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.18 medial geniculate complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.939567 MDA-MB-453 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.869916 CPLX1 Pathway Commons Protein-Protein Interactions 1.0 null central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.05447 sin3a_22783022_mcf7_lof_human_gpl570_gds4388 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 1.45206 Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OL-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SDE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27928 organelle outer membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.343421 pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07103 FOXS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.4278 fastigial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.07492 GSE175787_13_v_9_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XOTO-0011-R3A-SM-4B64W GTEx Tissue Sample Gene Expression Profiles 1.0 0.957476 Mitochondrial membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 abnormal digestive system physiology MPO Gene-Phenotype Associations 1.0 null PMC4029819-pone.0098069.s006.xlsx-Sheet1-Table_S5_FSS_analysis_of_FOXA1_high_versus_FOXA1_low_cases_in_metastases_p-value_0_01_FOXA1 Rummagene Transcription Factor Associations 2026 1.0 null WM88 CCLE Cell Line Gene CNV Profiles -1.0 -1.88612 Heart - Atrial Appendage GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.641933 hacat HPA Cell Line Gene Expression Profiles 1.0 1.0569 GSE140936,GSE140938_0_v_1_slfn11_human RummaGEO Gene Perturbation Signatures 1.0 null PMC12822963-pone.0339296.s005.xlsx-Sheet1-HIF1A_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null FOSL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null adult TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.492963 M band COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.608 Prostate adenocarcinoma_PRAD_TCGA-EJ-A65B-01A-12R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-103a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 PMC7247521__F6 PFOCR Pathway Figure Associations 2024 1.0 null GSE216043_7_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null COLO741 CCLE Cell Line Gene CNV Profiles 1.0 1.4394 COLO320 CCLE Cell Line Gene CNV Profiles -1.0 -1.42505 NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.48114 SLC46A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37738 Pancreatic adenocarcinoma_PAAD_TCGA-F2-A8YN-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EB2 CCLE Cell Line Gene CNV Profiles -1.0 -1.48416 GTEX-T5JW-1126-SM-4DM5V GTEx Tissue Sample Gene Expression Profiles 1.0 1.38017 MDAMB435S CCLE Cell Line Gene CNV Profiles -1.0 -2.09288 negatively GeneRIF Biological Term Annotations 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-8181-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A8P1-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Phosphocreatine MW Enzyme Metabolite Associations 1.0 null Prostate rhabdomyosarcoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.872 hsa-miR-4529-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 hsa-miR-1909 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 HECW2 Pathway Commons Protein-Protein Interactions 1.0 null hindlimb TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.278251 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.55 organelle LOCATE Predicted Protein Localization Annotations 1.0 null GSE233647_4_v_5_docetaxel_human RummaGEO Drug Perturbation Signatures -1.0 null alone GeneRIF Biological Term Annotations 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-A5NF-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal hearing physiology MPO Gene-Phenotype Associations 1.0 null hippocampus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09961 cochlear nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05586 Male reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.0 GTEX-XUZC-1326-SM-4BRV2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20497 IRS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20613 HS939T CCLE Cell Line Gene CNV Profiles -1.0 -1.36907 organelle envelope lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.11518 GTEX-T8EM-0526-SM-4DM64 GTEx Tissue Sample Gene Expression Profiles 1.0 0.898141 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4334-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null reticular nucleus of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.989763 Perturb_10154_KD_ZRSR2_SRP265290 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.04094 GSE239844_6_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null tamoxifen_homo sapiens_gpl96_gds2367 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-R55E-2526-SM-2TC6H GTEx Tissue Sample Gene Expression Profiles 1.0 1.1134 GSE253943_1_v_2_bhlhe40_human RummaGEO Gene Perturbation Signatures 1.0 null MAX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.7678 ASPM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35986 Lung adenocarcinoma_LUAD_TCGA-49-4486-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE165636_0_v_4_tofacitinib_human RummaGEO Drug Perturbation Signatures -1.0 null Rectum adenocarcinoma_READ_TCGA-DC-6160-01A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.33406 GTEX-N7MS-2526-SM-2D7W3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.897521 paraventricular nuclei, left of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.88626 abducens nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.8192 independence GeneRIF Biological Term Annotations 1.0 null 15492233-TableS1 GeneSigDB Published Gene Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A7AY-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE202434,GSE202438_7_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null NOL10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24245 CRCGN017_MCF10A.WT.HP_24H:J01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.46111 primary auditory cortex (core)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.968677 KSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47907 heart muscle HPA Tissue Protein Expression Profiles -1.0 -1.3208 GSE142430_3_v_1_prmt5_human RummaGEO Gene Perturbation Signatures -1.0 null HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.54252 respiratory system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EM-01A-21R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-NL4W-0011-R11A-SM-2I3DW GTEx Tissue Sample Gene Expression Profiles 1.0 1.13569 TRIM28 ENCODE Transcription Factor Targets 1.0 null C32TG Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01414 UNC45A Pathway Commons Protein-Protein Interactions 1.0 null caudal ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.56734 nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.940066 GSE168401_1_v_0_harmine_human RummaGEO Drug Perturbation Signatures -1.0 null IKZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.6138 GSE142210_11_v_0_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-05A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6960-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PSMB1 Pathway Commons Protein-Protein Interactions 1.0 null CALCOCO2 Pathway Commons Protein-Protein Interactions 1.0 null HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.60864 Brain Lower Grade Glioma_LGG_TCGA-DB-A64L-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsal lateral geniculate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.58364 thyroid gland disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.101049 Forebrain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC9646482-mmc13.xlsx-ST13B_AA-specific-regions-Unnamed_13_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null SOX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.9382 TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EKVX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.54252 NCI-H647 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.288 mediodorsal nucleus of thalamus_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.52601 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CO-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mediodorsal nucleus of thalamus_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.30647 GSE154337_0_v_1_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney Chromophobe_KICH_TCGA-KM-8477-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE134375_0_v_2_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XE-01A-12R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE205976,GSE205978_1_v_0_cep83_human RummaGEO Gene Perturbation Signatures 1.0 null GSE223241_2_v_0_cdkn2a_human RummaGEO Gene Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.923175 CRCGN014_HEPG2_24H:F21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9004 mRNA_POU5F1_20526341 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null VI, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06697 Perturb_2494_Mut_ESR1_SRP254635 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE143499_0_v_1_gata6_human RummaGEO Gene Perturbation Signatures 1.0 null ZBTB7C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.6367 Lung squamous cell carcinoma_LUSC_TCGA-63-A5MP-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE154350_1_v_0_ascl2_human RummaGEO Gene Perturbation Signatures 1.0 null CAMP_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null CRX_DN.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null TPP1 Pathway Commons Protein-Protein Interactions 1.0 null Rectum adenocarcinoma_READ_TCGA-EI-6509-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null other source TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.265381 NR3C1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.5716 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KH-01A-21R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null oculomotor nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14535 Telencephalon TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.033 GSX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27108 female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.419242 CRCGN009_HEPG2_24H:G16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.10066 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A3PH-01A-11R-A220-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_12_in_RNA-seq_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null HADHB Pathway Commons Protein-Protein Interactions 1.0 null GSE193258,GSE193259_5_v_1_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.30777 POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATP5B Pathway Commons Protein-Protein Interactions 1.0 null spinal trigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05652 Nerve - Tibial GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.636837 ZNF600 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59648 Intestinal disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.779 MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08948 GSE146612_2_v_0_amiodarone_human RummaGEO Drug Perturbation Signatures -1.0 null SF1 MotifMap Predicted Transcription Factor Targets 1.0 null FASTKD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60316 FLNA Pathway Commons Protein-Protein Interactions 1.0 null PMC12826982-mmc5.xlsx-Table_S4-Supplementary_Table_S4_Differentially_Bound_Down-regulated_Peak-Related_Genes_in_Flag-SOX3-HSV-1_vs_Flag-SOX3-Mock_SOX3 Rummagene Transcription Factor Associations 2026 1.0 null RNF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2871 SU-DHL-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.54596 Cerebellum TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 WIDR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09961 RNH1 Pathway Commons Protein-Protein Interactions 1.0 null tail TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.941785 496100484_FWM_no dementia_no TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.39781 Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7UY-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-0944-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210101,GSE210114_8_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null Fibre tract TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.598 heart disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.47901 ATP6V1G2 Pathway Commons Protein-Protein Interactions 1.0 null progressive muscular atrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.645375 CHAF1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04846 HOP-92 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.83443 Brain stem TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.598 hsa-miR-526b TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 GTEX-X4XX-2926-SM-3NMB1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.966328 brain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CRCGN011_HEPG2_24H:H06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.3894 PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_EC_CSc_vs_NB_2D_MSC Rummagene Transcription Factor Associations 2026 1.0 null CCKBR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14759 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A5W7-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S4P3-0426-SM-4AD56 GTEx Tissue Sample Gene Expression Profiles 1.0 0.952511 CRCGN015_HEPG2_48H:I07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.14924 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3465-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null QDPR Pathway Commons Protein-Protein Interactions 1.0 null TAL1::TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.5227 Diastolic blood pressure GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.0 GSE128730_7_v_2_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null globus pallidus, external segment, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.42338 heart TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.32461 CRCGN015_MCF10A_48H:F06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.6177 Genetic disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.584 Lung adenocarcinoma_LUAD_TCGA-55-8094-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null extracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 TAF1 ENCODE Transcription Factor Targets 1.0 null MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09961 Mitochondrial envelope COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 HSPD1 Pathway Commons Protein-Protein Interactions 1.0 null NUCKS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26627 MAPRE1 Pathway Commons Protein-Protein Interactions 1.0 null GSE128730_4_v_6_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE147876,GSE147877_2_v_10_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN015_HEPG2_48H:L20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.33103 dorsolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.03809 GTEX-R55F-1226-SM-2TF59 GTEx Tissue Sample Gene Expression Profiles 1.0 0.975624 Stomach GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.585875 TUBB6 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-R3RS-1326-SM-48FE7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.894128 Lung GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.619001 organelle envelope COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 male reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.108743 hematopoietic stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.070434 MKN-74 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.44232 PSMB2 Pathway Commons Protein-Protein Interactions 1.0 null disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041872 Mesothelioma_MESO_TCGA-MQ-A6BQ-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ANGPT2 Pathway Commons Protein-Protein Interactions 1.0 null HSPA5 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN012_HEPG2_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5381 motor nucleus of trigeminal nerve Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.06696 Lung squamous cell carcinoma_LUSC_TCGA-18-5595-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null limbic system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Lung oat cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.362 PMC4595011-pgen.1005555.s003.xlsx-BPTF_UP-regulated-Ensembl_gene_id_BPTF Rummagene Transcription Factor Associations 2026 1.0 null 496100409_FWM_no dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.14194 LCN10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92749 GSE142430_3_v_0_prmt5_human RummaGEO Gene Perturbation Signatures -1.0 null GSE142210_11_v_10_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null ID4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.427 myocardium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.4394 Lung squamous cell carcinoma_LUSC_TCGA-33-4547-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J9-A8CP-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null phenotypes GeneRIF Biological Term Annotations 1.0 null Electric organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.473 ventrolateral prefrontal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.23665 central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03679 SIN3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIX5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hindbrain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN015_MCF10A_48H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5299 Rectum adenocarcinoma_READ_TCGA-DC-5337-01A-01R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE148262,GSE150691_1_v_2_hdlbp_human RummaGEO Gene Perturbation Signatures -1.0 null CRISPLD2 Pathway Commons Protein-Protein Interactions 1.0 null NR2F2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.10818 inner SZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.01313 Prostate adenocarcinoma_PRAD_TCGA-CH-5741-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AA-39-BD24_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.240788 mitochondrion COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 HNRNPF Pathway Commons Protein-Protein Interactions 1.0 null 19204204-SupplementaryTable5 GeneSigDB Published Gene Signatures 1.0 null Female reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.017 ERR2 (ESRRB) MotifMap Predicted Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6496-01A-11R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JHOS2_OVARY CCLE Cell Line Proteomics 1.0 2.16943 PPARD JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.1577 HS706T CCLE Cell Line Gene CNV Profiles -1.0 -2.00401 CEP290 Pathway Commons Protein-Protein Interactions 1.0 null EIF6 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN010_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.09297 RELA JASPAR Predicted Transcription Factor Targets 1.0 null HUH6_LIVER CCLE Cell Line Proteomics 1.0 7.28635 TUBA4A Pathway Commons Protein-Protein Interactions 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-E5-A4U1-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-NJ-A55R-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MFE319 CCLE Cell Line Gene CNV Profiles -1.0 -1.81114 GSE195559_6_v_4_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null primary motor cortex (area M1, area 4)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.934383 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4699-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE120200,GSE127269_1_v_2_asxl1_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF354C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.625 GSE48812_9_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null Chorionic epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.535 GSE176008_7_v_2_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null Obesity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.434 GDI2 Pathway Commons Protein-Protein Interactions 1.0 null Adrenocortical carcinoma_ACC_TCGA-PK-A5HA-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NR4A2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.4849 GSE189609_1_v_0_hax1_human RummaGEO Gene Perturbation Signatures 1.0 null 496100608_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.33302 MYNN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09974 VZ in septal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.918939 GTEX-UPK5-1226-SM-4IHL8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.844461 GSE143944_1_v_0_ribociclib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PWCY-1026-SM-48TD4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.916818 Muscle tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.229 HEL9217 CCLE Cell Line Gene CNV Profiles 1.0 1.94349 VIIIA, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.22169 ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null USF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATP6V1A Pathway Commons Protein-Protein Interactions 1.0 null AA-23-FM46_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.221104 hypothyroidism DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.264431 OXCT1 Pathway Commons Protein-Protein Interactions 1.0 null SPDEF_01_189 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.67371 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XD-01A-22R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.21052 Acquired metabolic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.416 FNBP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10136 GSE223609,GSE223610_0_v_1_kdm6a_human RummaGEO Gene Perturbation Signatures -1.0 null 16728581-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null GSE128730_7_v_6_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null glycogen metabolism disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.102061 GSE175787_8_v_7_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null VZ in midcingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.954785 CRX_NRL_DN.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null GSE133516_0_v_3_kat7_human RummaGEO Gene Perturbation Signatures -1.0 null occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.844214 GSE175787_11_v_9_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null GSE230744,GSE237803_5_v_3_hira_human RummaGEO Gene Perturbation Signatures -1.0 null cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 abnormal synaptic transmission MPO Gene-Phenotype Associations 1.0 null MYRFL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38935 ATP6V1B2 Pathway Commons Protein-Protein Interactions 1.0 null HH CCLE Cell Line Gene CNV Profiles -1.0 -1.41867 Lung squamous cell carcinoma_LUSC_TCGA-22-5482-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE215849_2_v_1_muc1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE48812_7_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN014_HEPG2_3H:A14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.02468 GSE158834_10_v_9_palm_human RummaGEO Gene Perturbation Signatures -1.0 null KB-77-BA46_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.214054 PSMA7 Pathway Commons Protein-Protein Interactions 1.0 null colonrectum_d HPA Tissue Sample Gene Expression Profiles 1.0 0.883324 MPO Pathway Commons Protein-Protein Interactions 1.0 null FBH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15936 FOXP1-21924763-HESC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null EWSR1-FLI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 132.59 spinal cord TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.258917 PMC11257892-Table_1.xlsx-S2-Supplementary_Table_S2_All_results_of_the_preliminary_MR_analysis_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null Small_Intestine Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.837854 Liver hepatocellular carcinoma_LIHC_TCGA-ED-A97K-01A-21R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mitochondrial inner membrane GO Cellular Component Annotations 2023 1.0 null amygdaloid complex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.964324 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8046-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.98491 NCI-H2452 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.85884 Artery - Coronary GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.641933 GSE249098_1_v_0_mthfd1l_human RummaGEO Gene Perturbation Signatures -1.0 null pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.624361 Autosomal genetic disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.584 mitochondrial inner membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE210101,GSE210114_5_v_10_urod_human RummaGEO Gene Perturbation Signatures -1.0 null intracellular organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.579669 Brain Lower Grade Glioma_LGG_TCGA-HT-7603-01A-21R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PWO3-1026-SM-2I5F2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09308 creatine GeneRIF Biological Term Annotations 1.0 null GTEX-Q2AG-2826-SM-2HMJQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.985947 YBX1 Pathway Commons Protein-Protein Interactions 1.0 null CNTNAP2 Pathway Commons Protein-Protein Interactions 1.0 null paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.82843 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 Disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.453 CRCGN012_HEPG2_24H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.34818 PSMB3 Pathway Commons Protein-Protein Interactions 1.0 null animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null HCC2935 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.871179 Prostate adenocarcinoma_PRAD_TCGA-KK-A7B0-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 18504433-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null Lung adenocarcinoma_LUAD_TCGA-97-A4M3-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ADP HMDB Metabolites of Enzymes 1.0 null 697 CCLE Cell Line Gene CNV Profiles 1.0 1.42663 ST486 COSMIC Cell Line Gene Mutation Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A6I9-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-R55D-1826-SM-48FEF GTEx Tissue Sample Gene Expression Profiles 1.0 1.06733 16542501-SuppTable3 GeneSigDB Published Gene Signatures 1.0 null VZ in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.6666 TEAD4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 17297478-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null 15492233-TableS3 GeneSigDB Published Gene Signatures 1.0 null GTEX-T5JC-2426-SM-3NMDB GTEx Tissue Sample Gene Expression Profiles 1.0 0.920114 abnormal sensory capabilities/reflexes/nociception MPO Gene-Phenotype Associations 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-8629-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7S9-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YD-49-HM53_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.322745 ZNF274 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.2927 TRPS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.2181 GSE140997_4_v_7_nsun6_human RummaGEO Gene Perturbation Signatures -1.0 null Hippocampus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE195503_3_v_2_progesterone_human RummaGEO Drug Perturbation Signatures -1.0 null Lung carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.023 DCBLD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14853 VIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.02167 parataenial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.925076 proton-transporting ATP synthase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.97 496100362_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.70379 Acute Myeloid Leukemia_LAML_TCGA-AB-2847-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null female reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.057468 GSE230263,GSE230265_5_v_1_runx1_human RummaGEO Gene Perturbation Signatures 1.0 null UBE2K Pathway Commons Protein-Protein Interactions 1.0 null GSE95077_5_v_3_amiloride_human RummaGEO Drug Perturbation Signatures -1.0 null HT-29 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09847 Lung squamous cell carcinoma_LUSC_TCGA-22-5491-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE166783_4_v_2_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null PMPCA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.50217 extracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GTEX-S4P3-1226-SM-4AD4Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.09763 DDOST Pathway Commons Protein-Protein Interactions 1.0 null LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD Rummagene Transcription Factor Associations 2026 1.0 null Kidney Chromophobe_KICH_TCGA-KO-8408-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gluteal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.368624 GSE193993_4_v_3_sstr2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WWYW-3126-SM-3NB39 GTEx Tissue Sample Gene Expression Profiles 1.0 0.839499 longissimus thoracis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.257572 Lung adenocarcinoma_LUAD_TCGA-NJ-A4YF-01A-12R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-77-7139-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BARHL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.4456 mitochondrial envelope COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.375434 Adenosine triphosphate HMDB Metabolites of Enzymes 1.0 null Rectum adenocarcinoma_READ_TCGA-AF-5654-11A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EIF1B Pathway Commons Protein-Protein Interactions 1.0 null PRKRIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0569 DDX51 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13459 hsa-miR-4468 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 intracellular organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.459203 GTEX-WZTO-0011-R3B-SM-3NMC6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.845041 VZ in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.0058 GTEX-PLZ4-1626-SM-3P618 GTEx Tissue Sample Gene Expression Profiles 1.0 0.95711 PMC12436147-41380_2025_3032_MOESM1_ESM.xlsx-ST5-Supplementary_Table5_Brain_cortex_eQTLs_that_were_selected_as_instruments_for_the_MR_analyses_METABRAIN_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null EPCAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33772 TUBA1B Pathway Commons Protein-Protein Interactions 1.0 null Colorectum TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-U4B1-1126-SM-4DXV3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.30751 endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.427254 SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1565 abnormal locomotor activation MPO Gene-Phenotype Associations 1.0 null GTEX-WVLH-0011-R11A-SM-3MJFO GTEx Tissue Sample Gene Expression Profiles 1.0 0.889121 Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7318-01B-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5794-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100391_FWM_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.47791 myotube TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.562441 X, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.24505 spinal cord disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.142725 rna GeneRIF Biological Term Annotations 1.0 null COLO 794 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.61049 PMC6932815-ppat.1007634.s015.xlsx-ST5_DGE_ELF1-R8AvIFN48-mock_lfc-external_gene_name_ELF1 Rummagene Transcription Factor Associations 2026 1.0 null smooth muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.06386 CRCGN013_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.56599 FANCM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87475 SLC35A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09619 NUP160 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38622 DSP Pathway Commons Protein-Protein Interactions 1.0 null EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.21781 GSE146982_7_v_6_gpd1_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN014_HEPG2_24H:J18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8595 Prostate adenocarcinoma_PRAD_TCGA-Y6-A8TL-01A-21R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null masseter TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.242672 hippocampus (hippocampal formation)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.39336 midbrain reticular formation Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.989845 USF1 ENCODE Transcription Factor Targets 1.0 null MC116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.80771 CLIP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2985 Brain Lower Grade Glioma_LGG_TCGA-FG-A4MT-02A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIIIA, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.975045 erythrocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.471151 DETROIT 562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.43791 Acute Myeloid Leukemia_LAML_TCGA-AB-2966-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 18310505-TableS1 GeneSigDB Published Gene Signatures 1.0 null gigantocellular reticular nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.25716 PPP3R1 Pathway Commons Protein-Protein Interactions 1.0 null mifepristone_homo sapiens_gpl6947_gse39654 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null abnormal motor capabilities/coordination/movement MPO Gene-Phenotype Associations 1.0 null GSE216043_7_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null vascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053247 PMC6932815-ppat.1007634.s015.xlsx-ST5_DGE_ELF1-R8AvIFN48-mock_lfc-ensembl_gene_id_ELF1 Rummagene Transcription Factor Associations 2026 1.0 null GSE139455_7_v_6_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-OXRK-1326-SM-3NB1A GTEx Tissue Sample Gene Expression Profiles 1.0 0.854107 TUBA1C Pathway Commons Protein-Protein Interactions 1.0 null ME-31-RM40_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.238053 TAF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null alimentary canal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.779 Cardiovascular system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.017 CRCGN011_HEPG2_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.0421 NUP188 Pathway Commons Protein-Protein Interactions 1.0 null cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null GSE239844_8_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null choroid plexus of the fourth ventricle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19695 19658189-TableS4 GeneSigDB Published Gene Signatures 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y0-01A-12R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null prednisolone_homo sapiens_gpl570_gse32962 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YL-A8SL-01B-21R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN009_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.85536 REST_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-8276-01A-11R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.973 IRF4 ENCODE Transcription Factor Targets 1.0 null NUP153 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7736 Liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.063 subthalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04423 primary motor-sensory cortex (samples)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.06696 GTEX-RU72-0011-R2A-SM-2TF6O GTEx Tissue Sample Gene Expression Profiles 1.0 0.867196 PSMB7 Pathway Commons Protein-Protein Interactions 1.0 null GSE128730_4_v_2_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null phosphagen biosynthetic process GO Biological Process Annotations 2025 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6348-01A-11R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YY-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5744-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null acute myocardial infarction DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.71636 GTEX-R45C-1226-SM-48FEE GTEx Tissue Sample Gene Expression Profiles 1.0 0.824105 coronary artery TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.248683 mediodorsal nucleus of thalamus_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.2546 GSE181513_2_v_1_usp7_human RummaGEO Gene Perturbation Signatures 1.0 null abnormal voluntary movement MPO Gene-Phenotype Associations 1.0 null GEMIN4 Pathway Commons Protein-Protein Interactions 1.0 null inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.04476 GTEX-T6MN-0011-R10A-SM-32QP7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.93609 dorsal lateral geniculate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.974125 cytoplasmic part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 DDAH1 Pathway Commons Protein-Protein Interactions 1.0 null PLOD2 Pathway Commons Protein-Protein Interactions 1.0 null PMC4773428-ncomms10751-s5.xlsx-S_Table_4-Supplementary_Data_4_RUNX1_responsive_genes_in_the_presence_and_absence_of_estradiol_E2_in_MCF7_cells_FC_1_5_p_0_05_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null HCA-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.91389 Lung squamous cell carcinoma_LUSC_TCGA-66-2792-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null precommissural nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.872645 Acute Myeloid Leukemia_LAML_TCGA-AB-2935-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Organelle envelope COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 NCI-H2170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.859092 head of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.04622 GSE220058,GSE220059_0_v_1_prrc2b_human RummaGEO Gene Perturbation Signatures -1.0 null digestive/alimentary phenotype MPO Gene-Phenotype Associations 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-94-8490-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lung TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null 59M CCLE Cell Line Gene CNV Profiles -1.0 -1.36146 bj HPA Cell Line Gene Expression Profiles -1.0 -1.28527 cell culture TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.266413 EMX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.1525 GSE205163,GSE205164_2_v_0_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null GUSB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42976 L8 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.386 inner ear disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.229716 GSE213650_0_v_2_everolimus_human RummaGEO Drug Perturbation Signatures -1.0 null key GeneRIF Biological Term Annotations 1.0 null lncap GeneRIF Biological Term Annotations 1.0 null pore GeneRIF Biological Term Annotations 1.0 null internal female genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.377996 GSE240386,GSE242143_1_v_6_morc2_human RummaGEO Gene Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-YL-A9WH-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE139455_0_v_3_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8516-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null peripheral nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null KYSE-270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1565 POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in rostral cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.37454 Retinal cone TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.785 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7437-11A-01R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE128730_3_v_1_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null hippocampus (hippocampal formation)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.47024 GTEX-QMRM-1226-SM-447C6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.993168 UBE3B Pathway Commons Protein-Protein Interactions 1.0 null phosphocreatine metabolic process GO Biological Process Annotations 2023 1.0 null CC-68-YZ44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.265616 CRCGN016_MCF10A.WT.HP_24H:G16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.13391 GTEX-UJHI-1126-SM-4IHLN GTEx Tissue Sample Gene Expression Profiles 1.0 0.880204 IKBKE Pathway Commons Protein-Protein Interactions 1.0 null cerebellum TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE210662_3_v_0_znf165_human RummaGEO Gene Perturbation Signatures 1.0 null TM2D3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20448 COLO 205 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.937081 496100494_HIP_no dementia_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.26594 GTEX-WWYW-3026-SM-3NB36 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06887 PMC10111863-supp_gad.350269.122_Supplemental_Paun350269_FileS3.xlsx-A_ASCL1-regulated_DGE-geneID_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null MRPL16 Pathway Commons Protein-Protein Interactions 1.0 null PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Down_bins-Down_bins_loosing_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null abnormal cns synaptic transmission MPO Gene-Phenotype Associations 1.0 null PMC12436147-41380_2025_3032_MOESM1_ESM.xlsx-ST2-Supplementary_Table2_Blood_pQTLs_that_were_selected_as_genetic_instruments_for_MR_analyses_UKB_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.43385 GSE146982_0_v_1_gpd1_human RummaGEO Gene Perturbation Signatures 1.0 null Cerebral hemisphere TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29G-06A-12R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE164529_0_v_3_tamoxifen_human RummaGEO Drug Perturbation Signatures 1.0 null WNT5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31899 KARPAS-1106P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.0369 18338247-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null III Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.30521 20713713-TableS1a GeneSigDB Published Gene Signatures 1.0 null GEMIN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7697 GSE142210_4_v_0_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null DNM1 Pathway Commons Protein-Protein Interactions 1.0 null PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_x_CENPX Rummagene Transcription Factor Associations 2026 1.0 null GSE130401_4_v_3_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null abnormal prepulse inhibition MPO Gene-Phenotype Associations 1.0 null CTBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09275 REST_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TMA16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31861 RD_SOFT_TISSUE CCLE Cell Line Proteomics 1.0 2.48234 GTEX-P4QT-1426-SM-3NMCX GTEx Tissue Sample Gene Expression Profiles 1.0 1.13776 GTEX-XV7Q-2126-SM-4BRVX GTEx Tissue Sample Gene Expression Profiles 1.0 0.98537 inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.27344 Esophagus - Mucosa GTEx Tissue Gene Expression Profiles 2023 1.0 1.31246 cytoplasmic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.824959 GSE174701_1_v_0_maml3_human RummaGEO Gene Perturbation Signatures -1.0 null C3A CCLE Cell Line Gene CNV Profiles -1.0 -1.37558 SP1 ENCODE Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A299-01A-21R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -3.21951 myocarditis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.490835 RANBP6 Pathway Commons Protein-Protein Interactions 1.0 null MCM6 Pathway Commons Protein-Protein Interactions 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-5643-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.863 VIIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.839959 anterior (rostral) cingulate (medial prefrontal) cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.897696 GSE210682_0_v_3_methadone_human RummaGEO Drug Perturbation Signatures 1.0 null COLO829_SKIN CCLE Cell Line Proteomics 1.0 7.31312 NCIH596 CCLE Cell Line Gene CNV Profiles 1.0 1.8523 UBA1 Pathway Commons Protein-Protein Interactions 1.0 null REST_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null more GeneRIF Biological Term Annotations 1.0 null 19204204-SupplementaryTable1 GeneSigDB Published Gene Signatures 1.0 null GTEX-R55D-1126-SM-48FEB GTEx Tissue Sample Gene Expression Profiles 1.0 0.848383 vertebrate muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.49161 cell part LOCATE Predicted Protein Localization Annotations 1.0 null Cyclin D1-CDK4 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.537 PMC9692040-mmc1.xlsx-3_SAFB1_IP_significance-T_Gene_names_SAFB Rummagene Transcription Factor Associations 2026 1.0 null neuron part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.045354 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.18565 PAX5 ENCODE Transcription Factor Targets 1.0 null 16288205-GeneTable3 GeneSigDB Published Gene Signatures 1.0 null stomach TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064125 GSE146982_4_v_2_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null specificity GeneRIF Biological Term Annotations 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A69L-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A2M Pathway Commons Protein-Protein Interactions 1.0 null erythroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.180822 GTEX-XQ3S-1126-SM-4BOPK GTEx Tissue Sample Gene Expression Profiles 1.0 0.953995 NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08948 RAB35 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-RNOR-2226-SM-2TF5O GTEx Tissue Sample Gene Expression Profiles 1.0 1.0266 estradiol_homo sapiens_gpl570_gds3217 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-NK-A5CR-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VDR-33458620-PRIMARYEPITHELIAL-HUMAN-PROSTATE ChEA Transcription Factor Targets 2022 1.0 null VZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.33976 MM-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.72 Cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.787 20220088-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null GATA2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.9177 HCC1263 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.937081 nervous system phenotype MPO Gene-Phenotype Associations 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A560-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null aggressive GeneRIF Biological Term Annotations 1.0 null PTPN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46264 rhabdomyosarcoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.510344 PSMA3 Pathway Commons Protein-Protein Interactions 1.0 null regulator GeneRIF Biological Term Annotations 1.0 null SUM 229PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.49324 HSPA6 Pathway Commons Protein-Protein Interactions 1.0 null cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.185612 EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.19301 PLOD1 Pathway Commons Protein-Protein Interactions 1.0 null GATA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.2554 ZNF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18234 HOXB8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.5148 GSE161846,GSE161849_4_v_0_smarca4_human RummaGEO Gene Perturbation Signatures -1.0 null TCF12 ENCODE Transcription Factor Targets 1.0 null Metabolism Reactome Pathways 2024 1.0 null MCCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14603 Respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.023 centromedian nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.931042 PMC10709142-41556_2023_1281_MOESM2_ESM.xlsx-Supplementary_Table_1-CLUSTER_2_MAF_downregulated_MAF Rummagene Transcription Factor Associations 2026 1.0 null Vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.777 kinase GeneRIF Biological Term Annotations 1.0 null GTEX-XMK1-1326-SM-4B65Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.9163 GSE175787_13_v_2_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null GSE190316,GSE190324_1_v_9_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null PD-70-VS77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.20712 primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.973728 neurofibroma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.161523 CRCGN015_HEPG2_48H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.23811 TRIM21 Pathway Commons Protein-Protein Interactions 1.0 null ZSCAN4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.353 GTEX-WHSE-3026-SM-3P5ZH GTEx Tissue Sample Gene Expression Profiles 1.0 0.842304 V, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01221 PMC12041165-401_2025_2886_MOESM1_ESM.xlsx-Meta_CAA_vs_AD-Genes_TSHZ1 Rummagene Transcription Factor Associations 2026 1.0 null GSE206729_3_v_0_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null lateral reticular nucleus (principal part) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0225 VZ in subcallosal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.845094 NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.27467 OVCA 420 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.859092 PDIA4 Pathway Commons Protein-Protein Interactions 1.0 null CKS1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11075 PMC10290283-biol-2022-0622-sm3.pdf-402-FOXB1_FOXB1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE182680,GSE182683_0_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null III, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.23338 ALX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.7078 myocardial infarction DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.66195 Head And Neck Carcinoma DisGeNET Gene-Disease Associations 1.0 null endocrine system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.060826 KPL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null IV, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04351 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6956-01A-21R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.22174 gracile nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.968134 septal nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.17837 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-Row_names_CENPX Rummagene Transcription Factor Associations 2026 1.0 null intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.749546 species GeneRIF Biological Term Annotations 1.0 null MTF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.1221 GSE169356_2_v_3_ivermectin_human RummaGEO Drug Perturbation Signatures -1.0 null WC-16-IR43_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.35157 Vaginal epithelial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.201 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null NCI-H23 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.013 RPRD1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32109 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3453-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebral cortex TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Claw muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.895 intercalated nucleus of medulla Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.46282 vastus lateralis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.347408 organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.573411 ndpkd GeneRIF Biological Term Annotations 1.0 null membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Lung squamous cell carcinoma_LUSC_TCGA-60-2696-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal ear physiology MPO Gene-Phenotype Associations 1.0 null CRCGN012_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.68969 CRCGN009_HEPG2_24H:F19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.1863 nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.325187 abnormal vertical activity MPO Gene-Phenotype Associations 1.0 null CIAO1 Pathway Commons Protein-Protein Interactions 1.0 null YWHAG Pathway Commons Protein-Protein Interactions 1.0 null GSE163240_2_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null PMC4595011-pgen.1005555.s003.xlsx-BPTF_UP-regulated-Gene_name_BPTF Rummagene Transcription Factor Associations 2026 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7423-11A-01R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A550-01A-61R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE135439_0_v_1_pax5_human RummaGEO Gene Perturbation Signatures -1.0 null EE-03-SG02_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.565755 inner SZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.0355 creatine kinase activity GO Molecular Function Annotations 2025 1.0 null membrane GeneRIF Biological Term Annotations 1.0 null BCL11A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.5272 CRCGN012_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.2408 REST_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mitochondrial proton-transporting ATP synthase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.097 abnormal nervous system physiology MPO Gene-Phenotype Associations 1.0 null GSTM1 Pathway Commons Protein-Protein Interactions 1.0 null Natural killer cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.033 QF-71-QI30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.458278 PMC10742386-pnas.2311372120.sd05.xlsx-DLX3_ST-Gene_Symbol_DLX3 Rummagene Transcription Factor Associations 2026 1.0 null PMC12695649-41588_2025_2389_MOESM2_ESM.xlsx-GATA6_RIME-_AsPC-1-Gene_Symbol_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-A4JC-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.022 NCIH2066 CCLE Cell Line Gene CNV Profiles 1.0 1.43708 muscle fibre TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.520829 ST486 CCLE Cell Line Gene CNV Profiles 1.0 2.32794 JJN-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.923386 GSE158834_10_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN017_MCF10A.WT.HP_24H:E13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.24955 longissimus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.174651 Nutrition disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.443 PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR Rummagene Transcription Factor Associations 2026 1.0 null inferolateral temporal cortex (area TEv, area 20)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.841326 GTEX-RVPU-0011-R10A-SM-2XCAH GTEx Tissue Sample Gene Expression Profiles 1.0 0.866666 Cerebral lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.004 HCC827 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.859092 III, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.14444 Kidney Chromophobe_KICH_TCGA-KM-8476-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M6-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cerebral cortex TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.004 Twitch muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.029 PMC11961801-12672_2025_2262_MOESM2_ESM.xlsx-Sheet_1-WGCNA_AND_DEGs_NOT_CSGs_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null bone marrow cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.073885 FLI1::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.688 PRKDC Pathway Commons Protein-Protein Interactions 1.0 null GTEX-WZTO-0011-R4A-SM-3NMC7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.828824 endometritis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.319363 skeletal muscle HPA Tissue Protein Expression Profiles -1.0 -1.3208 PMC8384902-mmc3.xlsx-MS_from_ASCL1_co-IP-GENE_Symbol_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null skeletalmuscle_e HPA Tissue Sample Gene Expression Profiles -1.0 -1.16949 lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.9229 POU2F2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null principal sensory nucleus of trigeminal nerve Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.863888 bone marrow HPA Tissue Gene Expression Profiles -1.0 -1.08894 FOXP4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.8668 16288205-GeneTable4 GeneSigDB Published Gene Signatures 1.0 null GSE118490_1_v_0_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null 496100278_FWM_no dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.47472 PSMB6 Pathway Commons Protein-Protein Interactions 1.0 null OVISE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08948 muscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.917611 ZNF410 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.9259 GSE176008_0_v_2_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null decreased startle reflex MPO Gene-Phenotype Associations 1.0 null PROSER2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29372 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A7XN-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null bone marrow cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.094697 PMC6172843-13059_2018_1523_MOESM6_ESM.xls-Sheet1-Table_S5_mRNAs_variation_abundance_1_5-fold_in_YBX1-knockdown_BGC-823_cells_YBX1 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-4294 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 CD-13-QZ32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.314462 HIRIP3 Pathway Commons Protein-Protein Interactions 1.0 null Spleen Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.886207 neuromuscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.770435 Creatine metabolism Reactome Pathways 2014 1.0 null GSE188382_4_v_0_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null PMC3960207-oncotarget-05-0264-s002.xls-rank_down_foxp3_symb-Supplementary_Table_2_Genes_significantly_differentially_expressed_between_the_SK-MEL-28-FOXP3_and_SK-MEL-28-EV_clones_FOXP3 Rummagene Transcription Factor Associations 2026 1.0 null CALB1 Pathway Commons Protein-Protein Interactions 1.0 null BPNT1 Pathway Commons Protein-Protein Interactions 1.0 null YWHAE Pathway Commons Protein-Protein Interactions 1.0 null GSE175787_4_v_0_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null GSE129153_0_v_1_forskolin_human RummaGEO Drug Perturbation Signatures 1.0 null MSR1 Pathway Commons Protein-Protein Interactions 1.0 null Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 12829800-IntrinsicList GeneSigDB Published Gene Signatures 1.0 null reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.061526 Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.288 Placenta TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.017 gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.50275 gizzard TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.426872 organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.746689 GSE261563_9_v_1_atrx_human RummaGEO Gene Perturbation Signatures 1.0 null GSE211262,GSE211263_0_v_1_pbrm1_human RummaGEO Gene Perturbation Signatures -1.0 null APOBEC3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15413 GTEX-P44H-2426-SM-2XCEJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.953732 GTEX-QDVN-1326-SM-48TZ3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04117 ZNF589 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04688 GSE175787_5_v_6_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null Muscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.316 AP1M1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18684 GSE120612_6_v_5_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.60141 DAUDI CCLE Cell Line Gene CNV Profiles -1.0 -1.52721 akt GeneRIF Biological Term Annotations 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A7IQ-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A46F-01A-31R-A250-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UO31 CCLE Cell Line Gene CNV Profiles -1.0 -1.56611 liver_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.16949 VEZF1_02_179 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59082 KASUMI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.9439 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BE-01A-21R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE147366_1_v_4_med13_human RummaGEO Gene Perturbation Signatures -1.0 null PRDX1 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.916069 FOXP3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.8085 PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-upregulated_in_ATF4OE_txt-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null SNN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0967 GSE147876,GSE147877_2_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GTEX-PWN1-1426-SM-48TDF GTEx Tissue Sample Gene Expression Profiles 1.0 0.899606 EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.987729 NEUROG2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.7815 intracellular membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.495395 spine apparatus COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.185469 TTI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23491 Mesothelioma_MESO_TCGA-NQ-A638-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TPI1 Pathway Commons Protein-Protein Interactions 1.0 null GSE123958,GSE123959_0_v_1_mta1_human RummaGEO Gene Perturbation Signatures 1.0 null Salivary duct cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.178 GSE147876,GSE147877_4_v_10_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null PMC8174725-ppat.1009603.s006.xlsx-neg_nsp3-ZSGvs_Untr-nsp3-ZSG_PATZ1 Rummagene Transcription Factor Associations 2026 1.0 null GSE175787_4_v_10_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_MCF10A.TP53.M_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1095 FBXO2 Pathway Commons Protein-Protein Interactions 1.0 null GSE48812_9_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE228106_0_v_5_paclitaxel_human RummaGEO Drug Perturbation Signatures 1.0 null Conceptus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.97 ATOH7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.3206 GTPBP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02688 organelle inner membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 HINFP JASPAR Predicted Transcription Factor Targets 1.0 null GEMIN2 Pathway Commons Protein-Protein Interactions 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I7-01A-21R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-MP-A4T7-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MORC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69652 nature GeneRIF Biological Term Annotations 1.0 null extrinsic cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.55601 ADP MW Enzyme Metabolite Associations 1.0 null KHM-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.916947 Blood serum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.966 CKM complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.337 GSE158182_3_v_0_pnpla3_human RummaGEO Gene Perturbation Signatures 1.0 null GSE142210_11_v_7_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null overproduction GeneRIF Biological Term Annotations 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-BI-A20A-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE239844_8_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2A ENCODE Transcription Factor Targets 1.0 null Temporal lobe TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Metabolism of amino acids and derivatives Reactome Pathways 2014 1.0 null CLOCK JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.8427 GTEX-WVLH-0011-R10A-SM-3MJFM GTEx Tissue Sample Gene Expression Profiles 1.0 0.830281 HDDC2 Pathway Commons Protein-Protein Interactions 1.0 null HSP90AA1 Pathway Commons Protein-Protein Interactions 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-Q2AI-0926-SM-48U1F GTEx Tissue Sample Gene Expression Profiles 1.0 0.987422 GSE210101,GSE210114_6_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null YTHDF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65326 CREB1 JASPAR Predicted Transcription Factor Targets 1.0 null DCAF16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00106 membrane-bounded vesicle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 20368555-TS-2 GeneSigDB Published Gene Signatures 1.0 null SEC14L5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35154 HIV-1_LAI_12Hour-UV_treatment_None_GSE56484 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.26975 nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Coronary artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.948 PMC12702048-ijmsv23p0133s1.xlsx-Table_S1-Table_S1_Instrumental_variables_of_plasma_proteins_used_in_MR_analysis_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-Q2AG-0011-R11A-SM-2HMKZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.889413 GSE206729_4_v_0_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null HCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.937081 FXR MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-V955-1126-SM-4JBH3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.909619 NCI-H1869 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.83369 envelope COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.318579 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A6MF-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE245418_0_v_2_cd109_human RummaGEO Gene Perturbation Signatures -1.0 null PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST18-Supplementary_Data_18_Gene_burden_for_deletions_by_subtype_ST18 Rummagene Transcription Factor Associations 2026 1.0 null cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.18841 leg TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.33965 MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CLC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.15441 QA-07-KC40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.242413 Arginine and proline metabolism KEGG Pathways 2026 1.0 null extracellular region part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 PRTN3 Pathway Commons Protein-Protein Interactions 1.0 null skeletal system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.09739 SP2/0-AG14 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.091 496100543_FWM_probable Alzheimer's disease_TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.76598 VZ in caudal cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.01934 central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null QB-42-MC63_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.214043 VZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.26022 GSE224096_1_v_0_cocaine_human RummaGEO Drug Perturbation Signatures 1.0 null HB611 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.264 CRCGN015_MCF10A.TP53.M_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.0345 GSE123734_1_v_0_mien1_human RummaGEO Gene Perturbation Signatures -1.0 null DYNLL1 Pathway Commons Protein-Protein Interactions 1.0 null GSE142210_2_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null kinase1 GeneRIF Biological Term Annotations 1.0 null JHUEM3 CCLE Cell Line Gene CNV Profiles 1.0 1.55965 RFX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.3048 CAKI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.36622 GBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.9557 marrow cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.074103 PMC12749580-42003_2025_9274_MOESM5_ESM.xls-Supplementary_Data_2A-Supplementary_Table2A_Full_results_of_the_proteome-wide_MR_in_deCODE_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null 15220918-TableS1a GeneSigDB Published Gene Signatures 1.0 null spleen HPA Tissue Gene Expression Profiles -1.0 -0.987808 TUBB8 Pathway Commons Protein-Protein Interactions 1.0 null Creatine HMDB Metabolites of Enzymes 1.0 null A549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.922364 skin HPA Tissue Protein Expression Profiles 1.0 0.891551 REST_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE120756_2_v_9_tet2_human RummaGEO Gene Perturbation Signatures -1.0 null contractile fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.53413 CRCGN017_MCF10A.WT.HP_24H:G12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.17735 CALU Pathway Commons Protein-Protein Interactions 1.0 null VI, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.873196 GSE175787_8_v_2_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-T2IS-0011-R11A-SM-32QPC GTEx Tissue Sample Gene Expression Profiles 1.0 1.052 NUDT3 Pathway Commons Protein-Protein Interactions 1.0 null T24_URINARY_TRACT CCLE Cell Line Proteomics 1.0 2.51391 GSE210662_2_v_1_znf165_human RummaGEO Gene Perturbation Signatures -1.0 null medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.15824 PFDN2 Pathway Commons Protein-Protein Interactions 1.0 null GPC4 Pathway Commons Protein-Protein Interactions 1.0 null Lung adenocarcinoma_LUAD_TCGA-NJ-A4YP-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XQ3S-1426-SM-4BOPR GTEx Tissue Sample Gene Expression Profiles 1.0 0.870135 GSE202434,GSE202438_13_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null brain stem TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CRCGN017_MCF10A.WT.HP_24H:A13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.03665 NFE2L2_02_174 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.61569 GTEX-UJMC-1326-SM-4IHLS GTEx Tissue Sample Gene Expression Profiles 1.0 0.824682 PSMA2 Pathway Commons Protein-Protein Interactions 1.0 null Esophagus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.022 GSE114013,GSE114014_1_v_3_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null flexor TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.43146 GTEX-T6MN-0011-R11A-SM-32QOX GTEx Tissue Sample Gene Expression Profiles 1.0 1.02153 GSE48812_8_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null VIIB, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.27393 GDI1 Pathway Commons Protein-Protein Interactions 1.0 null TMCO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13856 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TA-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE217552_3_v_0_fisetin_human RummaGEO Drug Perturbation Signatures -1.0 null Creatine kinase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 3.13 GSE147876,GSE147877_2_v_11_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null SREBF2 JASPAR Predicted Transcription Factor Targets 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J1-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SOX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.2257 VZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.24381 RRBP1 Pathway Commons Protein-Protein Interactions 1.0 null CTCF ENCODE Transcription Factor Targets 1.0 null PMC3022822-1471-2164-12-11-S6.XLS-ES_enriched_list-Additional_File_6_Human_embryonic_stem_cells_genes_that_are_SOX2_targets_in_GBM_cells_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null TUBB Pathway Commons Protein-Protein Interactions 1.0 null RABIF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12262 LPCAT2 Pathway Commons Protein-Protein Interactions 1.0 null Squamous Cell Carcinoma DisGeNET Gene-Disease Associations 1.0 null Perturb_7412_KD_Nsun2_SRP018786 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -18.2757 GTEX-QCQG-0526-SM-48U2A GTEx Tissue Sample Gene Expression Profiles 1.0 1.01901 GSE233647_4_v_0_docetaxel_human RummaGEO Drug Perturbation Signatures -1.0 null RAB1A Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A6WI-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null catalytic complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.069799 Lung squamous cell carcinoma_LUSC_TCGA-18-5592-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A1207 CCLE Cell Line Gene CNV Profiles 1.0 1.63179 JUND ENCODE Transcription Factor Targets 1.0 null GSE130246_2_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null orbital frontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.919237 MAP1B Pathway Commons Protein-Protein Interactions 1.0 null REST_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE130437_2_v_1_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null ATP1A1 Pathway Commons Protein-Protein Interactions 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ED-A459-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WZTO-2826-SM-3NM8P GTEx Tissue Sample Gene Expression Profiles 1.0 1.09171 GSE202825_2_v_1_ano1_human RummaGEO Gene Perturbation Signatures 1.0 null SW1116 CCLE Cell Line Gene CNV Profiles -1.0 -1.7348 striatum_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.864101 GTEX-WHSE-0011-R11A-SM-3P5YY GTEx Tissue Sample Gene Expression Profiles 1.0 0.903953 537 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.75505 Brain Lower Grade Glioma_LGG_TCGA-DU-A7TC-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_3H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.2139 ZNF24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53155 GLIS3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.3416 muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.878605 REST_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inner SZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.853185 K029AX CCLE Cell Line Gene CNV Profiles 1.0 1.47343 Lung squamous cell carcinoma_LUSC_TCGA-66-2795-01A-02R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null uterine disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.088896 IMR-32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.44531 TUBB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24252 PMC3636213-pgen.1003459.s012.xlsx-Sheet1-KD_2_AR Rummagene Transcription Factor Associations 2026 1.0 null 18667080-TableS4 GeneSigDB Published Gene Signatures 1.0 null GTEX-RNOR-2326-SM-2TF4I GTEx Tissue Sample Gene Expression Profiles 1.0 0.929019 RUNX2 JASPAR Predicted Transcription Factor Targets 1.0 null GSE188570,GSE188571_3_v_1_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null intracellular COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.772732 GSE239688_2_v_1_canagliflozin_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_2604_OE_SEPTIN9_SRP159553 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.62899 PMC10679662-mmc2.xlsx-NC-D5-ZEB2-siRNA-Upregulated-Gene_Symbol_ZEB2 Rummagene Transcription Factor Associations 2026 1.0 null amygdaloid complex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.06948 Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.452 solitary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05467 glycogen storage disease ii DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.400826 shows GeneRIF Biological Term Annotations 1.0 null GSE242083,GSE242098_3_v_4_med1_human RummaGEO Gene Perturbation Signatures -1.0 null trunk TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.269867 AB-97-BI36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.267174 Lung adenocarcinoma_LUAD_TCGA-86-8673-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE184892_4_v_2_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null PMC10654515-41467_2023_43245_MOESM4_ESM.xlsx-Putative_ERG_binding_proteins-Unnamed_1_ERG Rummagene Transcription Factor Associations 2026 1.0 null skeletalmuscle_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.16949 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_y_CENPX Rummagene Transcription Factor Associations 2026 1.0 null ENO3 Pathway Commons Protein-Protein Interactions 1.0 null Cerebral cortex TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 USF1_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_10155_KD_ZRSR2_SRP265290 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.25795 GSE150895,GSE150896_0_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null decreased grooming behavior MPO Gene-Phenotype Associations 1.0 null CRCGN009_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.20355 ckmt1 GeneRIF Biological Term Annotations 1.0 null TK-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2133 Gizzard TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.131 GTEX-WL46-0011-R11A-SM-3MJFT GTEx Tissue Sample Gene Expression Profiles 1.0 1.06483 hematopoietic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052267 GTEX-QVUS-2926-SM-3GIJB GTEx Tissue Sample Gene Expression Profiles 1.0 1.22893 globus pallidus, internal segment, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.31378 GTEX-X4XX-0011-R11A-SM-46MWQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.891115 GSE185744,GSE185747_2_v_3_sox9_human RummaGEO Gene Perturbation Signatures -1.0 null SREBF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.292 blood plasma TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.749992 brain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.954271 Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-R55E-0011-R11A-SM-2TC6I GTEx Tissue Sample Gene Expression Profiles 1.0 1.00414 GTEX-P78B-1026-SM-3NMC4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0546 dorsal lateral geniculate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.848849 GTEX-XGQ4-1526-SM-4AT6H GTEx Tissue Sample Gene Expression Profiles 1.0 0.924914 GSE139455_0_v_6_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null NCI-H1792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.881151 Prostate adenocarcinoma_PRAD_TCGA-YJ-A8SW-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:D17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.19865 VIIIA, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1939 GSE48812_8_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.857591 RCBTB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33828 GSE233647_2_v_3_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null inner SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.854629 GSE57871_5_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null MYH9 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-QVUS-0011-R10A-SM-3GIK3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.843531 HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.02818 GSE231524,GSE231526_0_v_1_dusp6_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_HEPG2_48H:P13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.83377 PANC-04-03 COSMIC Cell Line Gene CNV Profiles -1.0 -3.83684 YWHAZ Pathway Commons Protein-Protein Interactions 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7220-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FZD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15901 HUTU80 CCLE Cell Line Gene CNV Profiles 1.0 1.43631 Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A40U-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE152734,GSE152735_2_v_0_pbrm1_human RummaGEO Gene Perturbation Signatures -1.0 null DTD1 Pathway Commons Protein-Protein Interactions 1.0 null Golgi cis cisterna COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.56 globus pallidus, external segment, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.46099 knockdown GeneRIF Biological Term Annotations 1.0 null PMC6145927-41467_2018_5729_MOESM6_ESM.xlsx-TF_Activity_Genesets-SNAIL_DN_SNAI1 Rummagene Transcription Factor Associations 2026 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 mitochondrial part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.675499 FBF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49281 Perturb_2488_Mut_ESR1_SRP254635 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE175787_13_v_10_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null UNCX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.6262 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.43385 ASAH1 Pathway Commons Protein-Protein Interactions 1.0 null EXOC1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-T2IS-3026-SM-32QPM GTEx Tissue Sample Gene Expression Profiles 1.0 0.904347 Adrenocortical carcinoma_ACC_TCGA-OR-A5LA-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WFG8-1326-SM-4LVN3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01483 Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE216540_1_v_6_fulvestrant_human RummaGEO Drug Perturbation Signatures -1.0 null FOSL2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE125219,GSE125221_4_v_2_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null PSMA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29583 Male reproductive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.0 PAX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.8204 Left atrium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.017 GTEX-N7MS-0011-R1a-SM-2HMJG GTEx Tissue Sample Gene Expression Profiles 1.0 0.83847 X, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.8085 Schwannomatosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.02 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AZ-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GUK1 Pathway Commons Protein-Protein Interactions 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7537-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hippocampus (hippocampal formation)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.02575 GTEX-PVOW-2526-SM-2XCF7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.882649 bonemarrow_6c HPA Tissue Sample Gene Expression Profiles -1.0 -1.16949 GSE164874_5_v_10_prednisolone_human RummaGEO Drug Perturbation Signatures 1.0 null PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim29_KD-Gene_names_AR Rummagene Transcription Factor Associations 2026 1.0 null colon TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null EIF5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93552 GTEX-QCQG-1626-SM-48U26 GTEx Tissue Sample Gene Expression Profiles 1.0 1.13238 GSE239688_2_v_5_canagliflozin_human RummaGEO Drug Perturbation Signatures 1.0 null OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.859092 GSE178292_0_v_3_melphalan_human RummaGEO Drug Perturbation Signatures 1.0 null medial superior olive Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.924719 GTEX-WZTO-0011-R11A-SM-4E3K9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.14208 GSE147876,GSE147877_4_v_8_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE217552_3_v_2_fisetin_human RummaGEO Drug Perturbation Signatures -1.0 null FOXP2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.2206 CYP19A1 Pathway Commons Protein-Protein Interactions 1.0 null muscle cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.419142 Respiratory system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.05 GSE56235_1_v_0_prdm11_human RummaGEO Gene Perturbation Signatures -1.0 null GSE147876,GSE147877_4_v_11_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Ischemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.115 dorsolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.848051 sensorineural hearing loss DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.277227 CRCGN015_HEPG2_48H:J23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.73945 PMC3296722-pone.0032481.s009.xlsx-Sheet_1_MSC_vs_references-Gene_Symbol_MSC Rummagene Transcription Factor Associations 2026 1.0 null MDH1 Pathway Commons Protein-Protein Interactions 1.0 null gastrointestinal tract TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.895 Prostate adenocarcinoma_PRAD_TCGA-EJ-5509-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null REST_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null mitochondrial GeneRIF Biological Term Annotations 1.0 null LS1034 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17066 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51E-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXO4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.9783 VZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.3448 GSE114284_4_v_0_irf1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE190316,GSE190324_1_v_11_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A6AP-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cardiac muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.42876 Adipose - Subcutaneous GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.644482 GSE195559_6_v_5_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null adipose-derived stromal cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.023 NGLY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31545 bone marrow TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.073004 YAE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 6.20024 CRCGN014_HEPG2_24H:I11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.86856 GSE216043_10_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE193258,GSE193259_2_v_12_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE175787_13_v_7_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null Heart TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.017 TRIM28_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebral hemisphere TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null central portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.50256 fetus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.276495 SK-OV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.35419 FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.1917 GTEX-S7SE-0011-R11A-SM-2XCDD GTEx Tissue Sample Gene Expression Profiles 1.0 0.919187 abnormal emotion/affect behavior MPO Gene-Phenotype Associations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7819-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0148 CAPN6 Pathway Commons Protein-Protein Interactions 1.0 null dorsolateral prefrontal cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.988303 RFX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.7636 SYN2 Pathway Commons Protein-Protein Interactions 1.0 null ATP5A1 Pathway Commons Protein-Protein Interactions 1.0 null Uterine luminal fluid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.007 CENPN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27972 Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9RE-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abdomen TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.107635 KARPAS-45 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE214382,GSE214383_0_v_2_ascl1_human RummaGEO Gene Perturbation Signatures -1.0 null PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1 Rummagene Transcription Factor Associations 2026 1.0 null IRF4_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN013_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.81001 raphe magnus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.50142 ZNF35 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.1231 PMC5524348-pone.0181667.s005.xlsx-Inflammation-MINT_SPEN Rummagene Transcription Factor Associations 2026 1.0 null PMC11110418-12864_2024_10412_MOESM1_ESM.xlsx-S_Table_3-Supplementary_Table_3_Detailes_of_the_instrumental_variables_of_plasma_proteins_used_in_replication_MR_analysis_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GDF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19989 creatine kinase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 2.09983 A498_KIDNEY CCLE Cell Line Proteomics 1.0 5.51702 GSE116930,GSE116935_3_v_0_hes7_human RummaGEO Gene Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-A4CN-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-P44H-0011-R11A-SM-2XCER GTEx Tissue Sample Gene Expression Profiles 1.0 0.910344 GTEX-SNOS-1226-SM-4DM5H GTEx Tissue Sample Gene Expression Profiles 1.0 1.28708 16670265-TableS1 GeneSigDB Published Gene Signatures 1.0 null CHD1-26751641-CHIP-SEQ-LNCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Tail TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.326 GTEX-WFG7-1526-SM-4LVMG GTEx Tissue Sample Gene Expression Profiles 1.0 1.0537 MDA-MB-468 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.922364 quadriceps TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.234016 GTEX-N7MS-0011-R10A-SM-2HMJK GTEx Tissue Sample Gene Expression Profiles 1.0 0.851611 posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.20746 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.918962 ANO6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27222 CRCGN009_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.06328 HDAC5 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN015_MCF10A.TP53.M_24H:P14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.03085 FOXO1::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.1198 496100554_FWM_no dementia_no TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.00878 NDUFB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41665 PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC Rummagene Transcription Factor Associations 2026 1.0 null FOSL2 ENCODE Transcription Factor Targets 1.0 null GTEX-RWS6-0826-SM-47JXF GTEx Tissue Sample Gene Expression Profiles 1.0 0.835798 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22726 skeletalmuscle_c HPA Tissue Sample Gene Expression Profiles -1.0 -1.16949 internal male genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.235457 decreased exploration in new environment MPO Gene-Phenotype Associations 1.0 null CRCGN015_MCF10A.WT.HP_24H:C18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.39815 temporal lobe TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null skeletal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.37636 GSE175787_8_v_9_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null PMC8582123-13073_2021_996_MOESM4_ESM.xlsx-SATB1-HIT_SATB1 Rummagene Transcription Factor Associations 2026 1.0 null spleen_3d HPA Tissue Sample Gene Expression Profiles -1.0 -1.16949 neurodegenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.098153 RAB3C Pathway Commons Protein-Protein Interactions 1.0 null CRCGN014_HEPG2_3H:M21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.46145 HEATR1 Pathway Commons Protein-Protein Interactions 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5740-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100277_FWM_no dementia_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.60371 decreased vertical activity MPO Gene-Phenotype Associations 1.0 null normoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.180822 abnormal defecation MPO Gene-Phenotype Associations 1.0 null Mitochondrial inner membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 HEPG2 CCLE Cell Line Gene CNV Profiles -1.0 -1.58084 UBC Pathway Commons Protein-Protein Interactions 1.0 null parafascicular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.975314 PXMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74074 GTEX-PWOO-1326-SM-48TCJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.983052 PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_down-regulated_in_Myc_KD_hESC_AR Rummagene Transcription Factor Associations 2026 1.0 null liver TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.293151 HSPA9 Pathway Commons Protein-Protein Interactions 1.0 null GSE183101_0_v_1_hvcn1_human RummaGEO Gene Perturbation Signatures -1.0 null EIF1B Hub Proteins Protein-Protein Interactions 1.0 null dorsal cochlear nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.882431 Slow muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.148 PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WZTO-2926-SM-3NM9I GTEx Tissue Sample Gene Expression Profiles 1.0 0.828779 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QJ-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10993587-12967_2024_4919_MOESM2_ESM.xlsx-Supplementary_Table_1-Supplementary_Table_1_Genetic_instruments_of_plasma_proteins_for_MR_analysis_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null Perturb_2055_KD_NR2F2_ERP124128 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GTEX-T6MN-0011-R1A-SM-32QOY GTEx Tissue Sample Gene Expression Profiles 1.0 0.895574 HAND2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7468 CALM1 Pathway Commons Protein-Protein Interactions 1.0 null Sigmoid_Colon Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.928301 GSE244518,GSE244520_1_v_0_dnmt3b_human RummaGEO Gene Perturbation Signatures 1.0 null GSE202434,GSE202438_2_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null PMC11820137-elife-98152-supp9.xlsx-Summary-SERBP1_interactors_NOT_in_any_membraneless_organelles_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null mitochondrial part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 contact site COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.26385 CRCGN012_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.28519 REST_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Unnamed_12_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null HUH6 CCLE Cell Line Gene CNV Profiles -1.0 -1.44215 asb9 GeneRIF Biological Term Annotations 1.0 null AE-39-DG66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.375989 MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ALB Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3328-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Tumor Cell Invasion DisGeNET Gene-Phenotype Associations 1.0 null GSE147876,GSE147877_4_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null 15897907-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null abnormal response to novelty MPO Gene-Phenotype Associations 1.0 null SGPL1 Pathway Commons Protein-Protein Interactions 1.0 null Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.425 Sarcoma_SARC_TCGA-IS-A3KA-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null hearing/vestibular/ear phenotype MPO Gene-Phenotype Associations 1.0 null mtck GeneRIF Biological Term Annotations 1.0 null muscle tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.918024 GSE210101,GSE210114_4_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null GSE191037_0_v_1_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.742769 urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.576415 MIXL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.6323 LTO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65354 GSE205163,GSE205164_3_v_0_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null Diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.232 GSE164505,GSE164506_3_v_2_indisulam_human RummaGEO Drug Perturbation Signatures -1.0 null body of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.826867 hippocampus (hippocampal formation)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.53223 Lung cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.024 Artery - Tibial GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.644482 TFAP4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 49.7607 CHCHD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02801 cerebral lobe TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MYC_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Photoreceptor inner segment COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.222 CRCGN017_MCF10A.TP53.M_24H:J04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.41275 MED31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12086 Crus II, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.09157 Nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN014_HEPG2_3H:I24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.37513 central glial substance Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.08849 spleen GTEx Tissue Gene Expression Profiles -1.0 -0.836752 GTEX-T5JW-1326-SM-4DM5G GTEx Tissue Sample Gene Expression Profiles 1.0 0.980005 FOXH1-21741376-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE95302_1_v_4_tamoxifen_human RummaGEO Drug Perturbation Signatures 1.0 null PSMG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.38853 GTEX-VJYA-2026-SM-4KL1K GTEx Tissue Sample Gene Expression Profiles 1.0 0.828885 SPN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1149 Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IJ-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null telencephalon TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE210101,GSE210114_5_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null organelle membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.289938 Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYB-26560356-CHIP-SEQ-TH1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null WEE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18832 SNU761 CCLE Cell Line Gene CNV Profiles 1.0 1.59476 PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_1_MITF Rummagene Transcription Factor Associations 2026 1.0 null Gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.21 PMC9692040-mmc1.xlsx-2_CRAPOME_FILTERED_SAFB-T_Gene_names_SAFB Rummagene Transcription Factor Associations 2026 1.0 null GSE147876,GSE147877_4_v_5_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.104285 CRCGN011_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.57085 GTEX-Q2AH-1226-SM-48TZL GTEx Tissue Sample Gene Expression Profiles 1.0 1.21269 sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042244 Lung squamous cell carcinoma_LUSC_TCGA-79-5596-01A-31R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE146982_4_v_2_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-NL3H-0011-R10A-SM-2I3E9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.917024 HSPA8 Pathway Commons Protein-Protein Interactions 1.0 null GSE169205_3_v_6_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null mitochondrial membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 SP1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LIG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13353 RKN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14951 POU6F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.7312 bounding membrane of organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.050736 FAM96B Pathway Commons Protein-Protein Interactions 1.0 null RAB14 Pathway Commons Protein-Protein Interactions 1.0 null Mesothelioma_MESO_TCGA-LK-A4O7-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SOX10 MotifMap Predicted Transcription Factor Targets 1.0 null GSE128730_0_v_1_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null DOK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Testis GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.638111 GSE157894_1_v_3_cystine_human RummaGEO Drug Perturbation Signatures 1.0 null OSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53919 Myocardial infarction DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.008 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null Colon TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 VZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.5358 mitochondrial intermembrane space COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.170114 Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUU-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null extracellular vesicle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 Ovary GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.619001 MAP1LC3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07006 GTEX-TSE9-0011-R11A-SM-3DB7N GTEx Tissue Sample Gene Expression Profiles 1.0 0.881901 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3443-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE232218_1_v_0_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-SOX2-Unnamed_4_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null hippocampus (hippocampal formation)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.66064 HOXB7_01_169 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.58506 NKX2-2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.9276 mitochondrial membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.063609 CUL3 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XLM4-2926-SM-4AT59 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0198 UT-7 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.766 GSE147876,GSE147877_2_v_6_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null t47d HPA Cell Line Gene Expression Profiles 1.0 0.908586 kinase activity GO Molecular Function Annotations 2023 1.0 null bulbourethral gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.536625 medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.963862 cytosolic creatine kinase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.48871 abnormal exploration in a new environment MPO Gene-Phenotype Associations 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-4396-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.77018 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70K-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null bed nucleus of stria terminalis, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.932053 GSE119978,GSE180930_0_v_7_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Bladder TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.067 YMB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.85884 ALPP Pathway Commons Protein-Protein Interactions 1.0 null Metencephalon TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.158 ARX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81878 HSPB1 Pathway Commons Protein-Protein Interactions 1.0 null GSE190316,GSE190324_10_v_9_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null SLC25A5 Pathway Commons Protein-Protein Interactions 1.0 null Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 oxygen GeneRIF Biological Term Annotations 1.0 null inner SZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.58706 GSE139455_2_v_3_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null anterior amygdaloid area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.834967 COLO 829 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15545 globus pallidus, internal segment, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.05965 HEL CCLE Cell Line Gene CNV Profiles 1.0 1.67035 phosphocreatine biosynthetic process GO Biological Process Annotations 2025 1.0 null PMC11459707-12890_2024_3289_MOESM1_ESM.xlsx-TableS3_MR_results-Supplementary_Table3_The_causal_effect_of_proteins_on_IPF_risk_from_Finngen_study_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QDT8-0011-R11A-SM-32PKD GTEx Tissue Sample Gene Expression Profiles 1.0 0.961015 GSE196962_4_v_3_parg_human RummaGEO Gene Perturbation Signatures -1.0 null phosphotransferase activity, nitrogenous group as acceptor GO Molecular Function Annotations 2025 1.0 null Lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.002 GSE156923_2_v_3_rbmx_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-X585-0011-R3B-SM-46MVG GTEx Tissue Sample Gene Expression Profiles 1.0 0.84888 amygdaloid complex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.41478 TUBB4B Pathway Commons Protein-Protein Interactions 1.0 null Hepatobiliary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.0 PMC11820137-elife-98152-supp9.xlsx-Summary-SERBP1_interactors_NOT_in_membraneless_organelles_not_tau_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null ZNF547 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.222 adult stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063529 Bronchoalveolar system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.306 Hematopoietic cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.033 496100616_FWM_no dementia_TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.49917 IKBKE Hub Proteins Protein-Protein Interactions 1.0 null AZU1 Pathway Commons Protein-Protein Interactions 1.0 null MYC_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hepatobiliary disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.061 GSE48812_4_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null GSE135352_0_v_4_napabucasin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE151612_4_v_8_pracinostat_human RummaGEO Drug Perturbation Signatures 1.0 null BACH1_02_188 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.63018 ZNF317 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.89 GSE240386,GSE242143_1_v_5_morc2_human RummaGEO Gene Perturbation Signatures -1.0 null HSPA14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53991 STAT6 MotifMap Predicted Transcription Factor Targets 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2862-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WHSE-2926-SM-3NMBG GTEx Tissue Sample Gene Expression Profiles 1.0 0.972103 BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.837369 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null PSMA6 Pathway Commons Protein-Protein Interactions 1.0 null EIF5A Pathway Commons Protein-Protein Interactions 1.0 null GSE182680,GSE182683_7_v_9_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RVH421_SKIN CCLE Cell Line Proteomics 1.0 2.06614 NR1H2::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 64.32 HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null GSE147876,GSE147877_2_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Dressler's syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.512 SCARB2 Pathway Commons Protein-Protein Interactions 1.0 null GSE205730,GSE205731_2_v_1_tazemetostat_human RummaGEO Drug Perturbation Signatures 1.0 null PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-fromNode_SOX4 Rummagene Transcription Factor Associations 2026 1.0 null MYH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06225 hsa-miR-650 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 JUND_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN008_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.60445 OSBPL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.68622 CEBPZ_02_05 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.65087 GTEX-QDT8-3026-SM-32PKB GTEx Tissue Sample Gene Expression Profiles 1.0 1.07286 VIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04847 GTEX-T2IS-2926-SM-32QPO GTEx Tissue Sample Gene Expression Profiles 1.0 1.09209 GSE158834_1_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null THBS1 Pathway Commons Protein-Protein Interactions 1.0 null cytoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.823123 Kidney Chromophobe_KICH_TCGA-KN-8419-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null KYSE-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.48114 Musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.127 GSE175787_11_v_6_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.575616 rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.42073 NEFM Pathway Commons Protein-Protein Interactions 1.0 null HOXA6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.2179 Metabolism Reactome Pathways 2014 1.0 null HLA-B Pathway Commons Protein-Protein Interactions 1.0 null HCC366 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.3033 GSE234289_5_v_0_rfx6_human RummaGEO Gene Perturbation Signatures -1.0 null GSE175787_8_v_6_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null Bronchial epithelium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.306 GATA3-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null PMC9601604-NIHMS1841143-supplement-SuppTable-3.xlsx-shared_upregulated-Genes_upregulated_in_the_absence_of_FOXO3_in_GSCs_and_aged_NSCs_FOXO3 Rummagene Transcription Factor Associations 2026 1.0 null PMC3226433-1756-8935-4-20-S1.XLS-Table_S5_Miz-1_KD_gene_exp_chan-Miz_KD_up_Myc_KD_down_AR Rummagene Transcription Factor Associations 2026 1.0 null SUDHL8 CCLE Cell Line Gene CNV Profiles -1.0 -2.20312 GTEX-RM2N-0926-SM-48FD1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.933419 mitochondrion LOCATE Predicted Protein Localization Annotations 1.0 null Reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.153 SNU668 CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.531 GSE80098,GSE80366_0_v_8_progesterone_human RummaGEO Drug Perturbation Signatures -1.0 null inner SZ in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.843922 KMH2 CCLE Cell Line Gene CNV Profiles 1.0 1.347 EEF1A1 Pathway Commons Protein-Protein Interactions 1.0 null GSE262134_0_v_1_dnajc12_human RummaGEO Gene Perturbation Signatures -1.0 null MSX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.9173 496100562_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.93953 LATS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08354 mitochondrial inner membrane GO Cellular Component Annotations 2025 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.02816 liver_c HPA Tissue Sample Gene Expression Profiles -1.0 -1.16949 CRCGN008_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.7119 CALU-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.52077 ALDOA Pathway Commons Protein-Protein Interactions 1.0 null GSE213650_3_v_1_everolimus_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN013_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.8416 Acute myocardial infarction DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.068 Lymphoid cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.033 amygdaloid complex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.932604 smoothmuscle_8b HPA Tissue Sample Gene Expression Profiles -1.0 -1.16949 SK-N-FI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.54596 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SHOX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.8266 Creatine MW Enzyme Metabolite Associations 1.0 null GUSB Pathway Commons Protein-Protein Interactions 1.0 null phosphocreatine biosynthetic process GO Biological Process Annotations 2023 1.0 null SMN2 Pathway Commons Protein-Protein Interactions 1.0 null BC-54-ON71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.306434 PIP4K2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04744 REST_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WZTO-0011-R10B-SM-4E3KB GTEx Tissue Sample Gene Expression Profiles 1.0 0.876559 NEUROG1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.8331 CRCGN017_MCF10A.WT.HP_24H:N03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.12134 FF-86-NH56_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.225533 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QC-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventriculus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.42191 FOXP2 ENCODE Transcription Factor Targets 1.0 null BXPC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.837369 Lung squamous cell carcinoma_LUSC_TCGA-85-A512-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VAMP2 Pathway Commons Protein-Protein Interactions 1.0 null GSE202434,GSE202438_7_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null cytosolic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.330966 RAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.5895 Perirenal adipose tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.034 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4114-01A-01R-1193-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WDR61 Pathway Commons Protein-Protein Interactions 1.0 null membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.410259 BMI1 Pathway Commons Protein-Protein Interactions 1.0 null intracellular part LOCATE Curated Protein Localization Annotations 1.0 null CRCGN015_MCF10A.TP53.M_24H:F21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4845 USP9X CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82863 sp2/0-ag14 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.695763 GSE210101,GSE210114_7_v_10_urod_human RummaGEO Gene Perturbation Signatures 1.0 null PMC4332150-msb0011-0775-sd13.xlsx-JUN-Prey_Gene_Symbol_JUN Rummagene Transcription Factor Associations 2026 1.0 null CBX3 ENCODE Transcription Factor Targets 1.0 null PEA15 Pathway Commons Protein-Protein Interactions 1.0 null HEYA8_OVARY CCLE Cell Line Proteomics 1.0 4.81133 SIX5 ENCODE Transcription Factor Targets 1.0 null membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE239688_2_v_3_canagliflozin_human RummaGEO Drug Perturbation Signatures 1.0 null juvenile spinal muscular atrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.716021 phosphocreatine metabolic process GO Biological Process Annotations 2025 1.0 null TUBB3 Pathway Commons Protein-Protein Interactions 1.0 null mitochondrial membrane GO Cellular Component Annotations 2025 1.0 null GSE200388_0_v_1_gemin5_human RummaGEO Gene Perturbation Signatures 1.0 null PMC11820137-elife-98152-supp9.xlsx-Summary-SERBP1_interactors_NOT_in_tau_aggregates_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN016_MCF10A.TP53.M_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.27081 VDR-23401126-LCL-AND-THP1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null striatum_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.38266 myeloid progenitor cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.073503 GSE146982_0_v_1_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XUZC-0426-SM-4BOPE GTEx Tissue Sample Gene Expression Profiles 1.0 0.825576 increased defecation amount MPO Gene-Phenotype Associations 1.0 null GSE205729,GSE205731_2_v_1_tazemetostat_human RummaGEO Drug Perturbation Signatures -1.0 null SNU-175 COSMIC Cell Line Gene Mutation Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SUM 149PT Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.61641 GSE120612_4_v_5_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE212848_1_v_0_pum1_human RummaGEO Gene Perturbation Signatures -1.0 null PMC7576810-41419_2020_3099_MOESM9_ESM.xlsx-MS_analysis_EVI1-WT_vs_EVI1-S43-Unnamed_0_MECOM Rummagene Transcription Factor Associations 2026 1.0 null KLHL36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45431 envelope COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 prostate sarcoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.986849 inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.93417 CTCF_kidney_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.316 GTEX-U3ZN-1726-SM-4DXUQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.896265 RFC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.3513 inner portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.832659 HCC366 CCLE Cell Line Gene CNV Profiles -1.0 -1.68319 umtck GeneRIF Biological Term Annotations 1.0 null cell part LOCATE Curated Protein Localization Annotations 1.0 null GTEX-WZTO-0011-R8A-SM-4E3II GTEx Tissue Sample Gene Expression Profiles 1.0 0.868526 organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.044724 GSE213650_0_v_1_everolimus_human RummaGEO Drug Perturbation Signatures -1.0 null PTBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14978 SNU-C1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.937081 REST_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SEC16A Pathway Commons Protein-Protein Interactions 1.0 null GSE227698_5_v_4_g0s2_human RummaGEO Gene Perturbation Signatures -1.0 null Mitochondrial intermembrane space COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.442 AE-39-DG66_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.212627 ETV1_01_36 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 0.98306 Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A67A-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FBXO10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10603 CRCGN015_MCF10A.WT.HP_24H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.31723 EML2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17259 PRRX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.369 496100514_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.7674 androgen GeneRIF Biological Term Annotations 1.0 null some GeneRIF Biological Term Annotations 1.0 null GSE224096_2_v_0_cocaine_human RummaGEO Drug Perturbation Signatures 1.0 null abnormal response to new environment MPO Gene-Phenotype Associations 1.0 null tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 Cerebral gyrus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.033 GSE205163,GSE205164_9_v_4_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null GSE236437_2_v_3_aldosterone_human RummaGEO Drug Perturbation Signatures -1.0 null 17823660-TableS2 GeneSigDB Published Gene Signatures 1.0 null GSE233647_4_v_6_docetaxel_human RummaGEO Drug Perturbation Signatures -1.0 null PMC5195898-NIHMS825571-supplement-3.xlsx-Sheet1-H1975_M1_vs_H1975_M1_CIC_reconstitution_Differential_gene_expression_CIC Rummagene Transcription Factor Associations 2026 1.0 null DLST Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11474168-ccr-23-1242_supplementary_table_s4_suppst4.xlsx-AR_tumors_genes-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null TE6 CCLE Cell Line Gene CNV Profiles 1.0 2.04104 GSE178907_0_v_3_fkrp_human RummaGEO Gene Perturbation Signatures -1.0 null lateral parabrachial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.05589 FAR1 Pathway Commons Protein-Protein Interactions 1.0 null Cerebral lobe TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE158834_0_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null primary motor-sensory cortex (samples)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.35692 GTEX-R55E-1326-SM-48FCR GTEx Tissue Sample Gene Expression Profiles 1.0 0.932532 GTEX-OXRL-0626-SM-3NM9C GTEx Tissue Sample Gene Expression Profiles 1.0 0.897692 Pancreatic adenocarcinoma_PAAD_TCGA-US-A77G-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Crus II, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19889 GSE130246_1_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null SVOPL Pathway Commons Protein-Protein Interactions 1.0 null VZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.14026 abnormal behavior MPO Gene-Phenotype Associations 1.0 null Uterine fluid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.626 mediodorsal nucleus of thalamus_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.37326 19808870-ST1 GeneSigDB Published Gene Signatures 1.0 null Carcinogenesis DisGeNET Gene-Phenotype Associations 1.0 null u138mg HPA Cell Line Gene Expression Profiles -1.0 -1.28527 nucleus coeruleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.53904 colon_8b HPA Tissue Sample Gene Expression Profiles 1.0 0.835098 GTEX-OXRK-1726-SM-3NB16 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08005 GTEX-X261-0011-R11A-SM-4E3JY GTEx Tissue Sample Gene Expression Profiles 1.0 1.06589 GSE174701_1_v_7_maml3_human RummaGEO Gene Perturbation Signatures -1.0 null putamen, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.0098 mitochondrial outer membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.365095 BICR 31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null HBA2 Pathway Commons Protein-Protein Interactions 1.0 null USF1_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CYP11A1 Pathway Commons Protein-Protein Interactions 1.0 null GSE192870_2_v_0_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null Electrocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.731 Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6II-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRDM1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.2946 disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.06858 ASPH Pathway Commons Protein-Protein Interactions 1.0 null Hindbrain TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.158 YWHAB Pathway Commons Protein-Protein Interactions 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-21-1076-01A-01R-0692-07,TCGA-21-1076-01A-02R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.43755 SLC52A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40051 behavior/neurological phenotype MPO Gene-Phenotype Associations 1.0 null Large granular lymphocyte TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.033 VIIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2725 MAP7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47878 NFATC4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.8198 TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null RT4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25637 dissipation GeneRIF Biological Term Annotations 1.0 null intracellular organelle LOCATE Curated Protein Localization Annotations 1.0 null HCC-366 COSMIC Cell Line Gene Mutation Profiles 1.0 null lipids GeneRIF Biological Term Annotations 1.0 null dorsolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.35037 MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Intestine TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BHLHE23 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.1763 GTEX-XMK1-1726-SM-4B64Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.09607 membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null USF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34897 contributes GeneRIF Biological Term Annotations 1.0 null PTDSS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01086 CRCGN013_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.61113 CDIPT Pathway Commons Protein-Protein Interactions 1.0 null GSE133087_1_v_0_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null hippocampus (hippocampal formation)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.12288 POLR2D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74357 POMGNT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11674 K-562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17066 M14 COSMIC Cell Line Gene Mutation Profiles 1.0 null rara_21299862_mcf7_lof_human__gds4065 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.432787 mediodorsal nucleus of thalamus_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.3649 viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.49844 HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02323 male infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.36704 18223198-TableS3 GeneSigDB Published Gene Signatures 1.0 null smooth muscle HPA Tissue Protein Expression Profiles -1.0 -1.3208 ANXA2 Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8107-01A-13R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 1.13401 Trophoblast stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.619 NCI-H345 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE206729_5_v_0_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE146840,GSE146842_3_v_2_qrich1_human RummaGEO Gene Perturbation Signatures -1.0 null Gastrointestinal system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.779 CRCGN011_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.4803 GTEX-WVLH-2926-SM-3MJG5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05256 small intestine HPA Tissue Protein Expression Profiles 1.0 1.40979 FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null ITGA11 Pathway Commons Protein-Protein Interactions 1.0 null pectoral muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.530693 RCM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09961 creatine kinase activity GO Molecular Function Annotations 2023 1.0 null SENP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25993 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null CKM Pathway Commons Protein-Protein Interactions 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7152-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXO6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.1882 STXBP1 Pathway Commons Protein-Protein Interactions 1.0 null Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.584 HADHA Pathway Commons Protein-Protein Interactions 1.0 null GSE184892_7_v_2_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null UCHL1 Pathway Commons Protein-Protein Interactions 1.0 null GSE175787_11_v_2_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null EN1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.6165 intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.306 NEUROD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.8685 GSE146982_7_v_1_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.49499 Peripheral nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PSMD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93498 cytoplasmic part LOCATE Curated Protein Localization Annotations 1.0 null GSE223241_1_v_3_cdkn2a_human RummaGEO Gene Perturbation Signatures -1.0 null TBC1D2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46785 anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.917045 organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.488115 Fast muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.73 MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_HEPG2_48H:A14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.01868 CRCGN008_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1185 CRCGN013_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7991 Integument TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.306 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JUN JASPAR Predicted Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5432-01A-02R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PLAA Pathway Commons Protein-Protein Interactions 1.0 null GTEX-T5JC-0011-R11A-SM-32PMB GTEx Tissue Sample Gene Expression Profiles 1.0 0.92894 skbr3 HPA Cell Line Gene Expression Profiles 1.0 0.987276 RBM28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13269 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6ES-01A-12R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE242290_3_v_10_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null hippocampus (hippocampal formation)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.859474 U937_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 8.92863 Hematologic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.042 PMC6932815-ppat.1007634.s011.xlsx-ST1_DGE_ELF1_lfc2_fdr05_interse-geneID_ELF1 Rummagene Transcription Factor Associations 2026 1.0 null PCP4 Pathway Commons Protein-Protein Interactions 1.0 null erythroid cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.180822 GSE240030,GSE252532_0_v_2_atrx_human RummaGEO Gene Perturbation Signatures -1.0 null XRCC5_02_159 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.65603 duchenne muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.631991 Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A620-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.WT.HP_24H:P23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.56906 PMC11186850-CNS-30-e14817-s001.xlsx-STable5-Supplementary_Table_5_MR_Analysis_results_for_suggestive_associations_along_with_the_results_of_sensitivity_analyses_and_co-localization_analyses_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null leg muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.639619 Kidney renal clear cell carcinoma_KIRC_TCGA-B2-3923-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Myxedema DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.465 Perturb_2824_KD_KMT9A_SRP154908 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.0946 bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.585386 Myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.218 PSMD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02258 CGTHW1 CCLE Cell Line Gene CNV Profiles -1.0 -1.6655 Prefrontal cortex TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.004 GSE182680,GSE182683_0_v_9_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PSDG-1326-SM-48TD2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.931018 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-UC-A7PD-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null prostate cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.138488 PCP4L1 Pathway Commons Protein-Protein Interactions 1.0 null GSE175787_13_v_0_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null NCIH854 CCLE Cell Line Gene CNV Profiles 1.0 1.89792 Lung squamous cell carcinoma_LUSC_TCGA-34-5240-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PBDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7747 JHUEM2_ENDOMETRIUM CCLE Cell Line Proteomics 1.0 3.15298 Cerebral peduncle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.598 mitochondrial creatine kinase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.90979 Acute Myeloid Leukemia_LAML_TCGA-AB-2916-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KLF4_01_339 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.61072 Mitochondrial creatine kinase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 3.141 extracellular vesicular exosome COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Tongue-epithelial cell Tabula Sapiens Gene-Cell Associations 1.0 9.35303 Nuclear cyclin-dependent protein kinase holoenzyme complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.965 TUBB2A Pathway Commons Protein-Protein Interactions 1.0 null FLNC Pathway Commons Protein-Protein Interactions 1.0 null outer portion of lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.845416 auditory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.064132 head of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.29519 GSE175787_11_v_7_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null abdominal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.326067 GSE125014_1_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null Cerebral hemisphere TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.033 Uterine Carcinosarcoma_UCS_TCGA-NG-A4VW-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null reticular nucleus of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.956921 motor neuron disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.137751 BICDL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40513 GSE203017_0_v_1_irs2_human RummaGEO Gene Perturbation Signatures -1.0 null FOXA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.0649 REST_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX::MYC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.0476 outer membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.383509 TEAD4 ENCODE Transcription Factor Targets 1.0 null duodenum HPA Tissue Protein Expression Profiles 1.0 1.40979 PSMA4 Pathway Commons Protein-Protein Interactions 1.0 null rectum HPA Tissue Protein Expression Profiles 1.0 1.40979 esophagus HPA Tissue Protein Expression Profiles 1.0 1.40979 DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.8073 central gray of the pons, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.891636 head muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.124034 GSE147876,GSE147877_2_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null TUBA1A Pathway Commons Protein-Protein Interactions 1.0 null Perturb_979_OE_NANOGP8_SRP065951 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.60239 PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim22_KD-Gene_names_AR Rummagene Transcription Factor Associations 2026 1.0 null mediodorsal nucleus of thalamus_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.1134 EA-40-KQ08_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.223184 lateral ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.40523 Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.207 striatum_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.09022 Overnutrition DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.44 MYC_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IX Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.10913 FOXP2_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.61187 GTEX-S4Q7-0826-SM-4AD5E GTEx Tissue Sample Gene Expression Profiles 1.0 0.909735 GSE216540_10_v_6_fulvestrant_human RummaGEO Drug Perturbation Signatures -1.0 null GSE213650_3_v_2_everolimus_human RummaGEO Drug Perturbation Signatures -1.0 null GSE113817_0_v_1_bach1_human RummaGEO Gene Perturbation Signatures -1.0 null PMC11459707-12890_2024_3289_MOESM1_ESM.xlsx-Table_S8_MR_results-Supplementary_Table8_The_causal_effect_of_proteins_on_IPF_risk_from_UK_Biobank_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null VZ in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.42158 SIN3A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE118548_1_v_0_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null NCIH660 CCLE Cell Line Gene CNV Profiles -1.0 -1.33239 abnormal defecation amount MPO Gene-Phenotype Associations 1.0 null Pectoral muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.349 MAF-26560356-CHIP-SEQ-TH1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2941-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE178907_4_v_3_fkrp_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null LC-12-VN85_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.272556 membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041537 Abdominal obesity-metabolic syndrome DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.584 Respiratory epithelium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.306 MSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.6802 head TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null FOXP1-21924763-HESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null FC-20-EQ58_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.283769 CRCGN014_HEPG2_24H:I12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.7144 Lung adenocarcinoma_LUAD_TCGA-55-8204-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null THRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.7363 KCNMB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4668 PMC5806898-pbio.2004411.s003.xlsx-MR_plot_data-Gene_names_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null large intestine TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null abnormal locomotor behavior MPO Gene-Phenotype Associations 1.0 null SOX10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28227 causes GeneRIF Biological Term Annotations 1.0 null Artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.79 organelle envelope COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.328708 CRCGN011_HEPG2_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.2452 496100396_HIP_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.25438 GSE205729,GSE205731_2_v_3_tazemetostat_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN010_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.7191 ARL8B Pathway Commons Protein-Protein Interactions 1.0 null GSE48812_3_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null DNTTIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.16287 bexarotene_homo sapiens_gpl96_gds2777 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SERPINH1 Pathway Commons Protein-Protein Interactions 1.0 null GSE147876,GSE147877_4_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Cytosolic creatine kinase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.972 mitochondrial membrane GO Cellular Component Annotations 2023 1.0 null outer portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.38331 GSE110268_1_v_3_foxd1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE151612_0_v_8_pracinostat_human RummaGEO Drug Perturbation Signatures 1.0 null cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.328469 GTEX-WVLH-3026-SM-3MJG9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.85241 GSE244710_1_v_0_srsf1_human RummaGEO Gene Perturbation Signatures -1.0 null REST_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null musculoskeletal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.059737 GSE126463_1_v_3_pomalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE140937,GSE140938_0_v_2_slfn11_human RummaGEO Gene Perturbation Signatures 1.0 null Phosphocreatine HMDB Metabolites of Enzymes 1.0 null imatinib_homo sapiens_gpl96_gds3045 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GRB10 Pathway Commons Protein-Protein Interactions 1.0 null Disease Progression HuGE Navigator Gene-Phenotype Associations 1.0 null Kidney - Medulla GTEx Tissue Gene Expression Profiles 2023 1.0 3.71278 SKP1 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN012_HEPG2_24H:D08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.2501 phosphatidylcholine GeneRIF Biological Term Annotations 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2765-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver Carcinoma DisGeNET Gene-Disease Associations 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BC-4072-01B-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WFG8-1626-SM-4LVMB GTEx Tissue Sample Gene Expression Profiles 1.0 0.858819 GAS2L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.81719 brain cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.072236 electric organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.00022 substantia nigra, pars reticulata, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.29204 EBC1 CCLE Cell Line Gene CNV Profiles 1.0 2.23472 abnormal reflex MPO Gene-Phenotype Associations 1.0 null CORL23 CCLE Cell Line Gene CNV Profiles -1.0 -1.80191 SPATA24 Pathway Commons Protein-Protein Interactions 1.0 null coronary artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.62023 Lung squamous cell carcinoma_LUSC_TCGA-33-4583-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ARF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25163 Prostate adenocarcinoma_PRAD_TCGA-G9-6338-01A-12R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.99467 membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null Leaf disc TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.91 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F1-01A-11R-A034-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null distinct GeneRIF Biological Term Annotations 1.0 null PMC12729234-10194_2025_2222_MOESM1_ESM.xlsx-Table_S3-Table_S3_MR_results_of_the_586_significant_genes_from_TG_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null Type 2 diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.156 MOLM-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.85884 Brain Lower Grade Glioma_LGG_TCGA-HT-7607-01A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF189 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.2117 ZNF701 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 65.8329 RPMI 8226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.923386 ATP MW Enzyme Metabolite Associations 1.0 null Autosomal dominant disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.584 rectum_8d HPA Tissue Sample Gene Expression Profiles 1.0 0.829193 GSE196962_2_v_6_parg_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WL46-2826-SM-3LK81 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0587 GSE125014_6_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null substantia nigra, pars reticulata, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.16717 ANKAR Pathway Commons Protein-Protein Interactions 1.0 null SNU475 CCLE Cell Line Gene CNV Profiles 1.0 2.89919 neuropathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.616703 SUZ12 Pathway Commons Protein-Protein Interactions 1.0 null hindbrain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-WFON-1426-SM-4LVMT GTEx Tissue Sample Gene Expression Profiles 1.0 1.01289 GTEX-T6MN-2526-SM-32PMN GTEx Tissue Sample Gene Expression Profiles 1.0 1.08187 Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3TU-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN008_HEPG2_24H:L21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0129 hematopoietic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.809386 Atrium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.017 Outer nuclear layer TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.049 TGFBR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26283 MCF10DCIS.COM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.23145 AA-22-UI44_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.591859 spinal muscular atrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.142878 NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.859092 Lung adenocarcinoma_LUAD_TCGA-78-7540-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MBTPS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4892 Acute Myeloid Leukemia_LAML_TCGA-AB-2848-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LDHAL6A Pathway Commons Protein-Protein Interactions 1.0 null colon GTEx Tissue Gene Expression Profiles 1.0 0.873765 GR-ST COSMIC Cell Line Gene Mutation Profiles 1.0 null ATP6V0D1 Pathway Commons Protein-Protein Interactions 1.0 null BC-54-ON71_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.288382 GSE172016_2_v_5_paclitaxel_human RummaGEO Drug Perturbation Signatures 1.0 null VIIIA Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.13995 V Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.991838 myositis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.401199 blood TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.801459 artery TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05736 Lung adenocarcinoma_LUAD_TCGA-73-4670-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.20455 GTEX-X585-0011-R10A-SM-46MUY GTEx Tissue Sample Gene Expression Profiles 1.0 0.840169 SRF JASPAR Predicted Transcription Factor Targets 1.0 null CRCGN011_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.65985 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.775471 Creatine metabolism Reactome Pathways 2024 1.0 null RSL1D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43208 IPO4 Pathway Commons Protein-Protein Interactions 1.0 null JAR cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.712 PMC8185471-mmc4.xlsx-D2-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_2_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15 Rummagene Transcription Factor Associations 2026 1.0 null HOXB7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.0499 FZD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56619 GSE205730,GSE205731_2_v_3_tazemetostat_human RummaGEO Drug Perturbation Signatures 1.0 null SP1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_EVT-Gene_Symbol_GCM1 Rummagene Transcription Factor Associations 2026 1.0 null UM-UC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.922364 TYSND1 Pathway Commons Protein-Protein Interactions 1.0 null Telencephalon TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ISX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.2672 vesicle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 POU5F1_01_42 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.66385 Nasopharyngeal Carcinoma DisGeNET Gene-Disease Associations 1.0 null GSE163240_3_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null prostate rhabdomyosarcoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.27955 placenta TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.262986 GSE110248_1_v_6_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null medial ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.974465 intracellular membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null VIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.930564 CRCGN015_HEPG2_48H:L02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.0231 CLOCK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31116 blood vessel TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053943 caudal ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.2739 INO80C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71408 Acquired Immunodeficiency Syndrome HuGE Navigator Gene-Phenotype Associations 1.0 null COLO679 CCLE Cell Line Gene CNV Profiles -1.0 -1.51417 SP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:B23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4054 Lung squamous cell carcinoma_LUSC_TCGA-68-7755-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H2804 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.937081 Lung squamous cell carcinoma_LUSC_TCGA-22-5474-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.57626 GSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.7234 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3433-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FYCO1 Pathway Commons Protein-Protein Interactions 1.0 null skeletalmuscle_b HPA Tissue Sample Gene Expression Profiles -1.0 -1.16949 PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_17_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null GSE202434,GSE202438_7_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null transferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.084875 PANC 02.03 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.85884 Lung squamous cell carcinoma_LUSC_TCGA-22-4604-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gastrointestinal tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053277 PMC11110418-12864_2024_10412_MOESM1_ESM.xlsx-S_Table_2-Supplementary_Table_2_Detailes_of_the_instrumental_variables_of_plasma_proteins_used_in_discovery_MR_analysis_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null REST_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.64532 extensor TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.33413 STK33_NOMO MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null arginine and proline metabolism KEGG Pathways 1.0 null GSE216540_0_v_6_fulvestrant_human RummaGEO Drug Perturbation Signatures -1.0 null GSE147876,GSE147877_2_v_5_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null VDR-23401126-LCL-AND-THP1-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null sacrospinalis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.153837 OLIG1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.247 GSE208171_0_v_1_zc4h2_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN009_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.15286 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4725-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.30777 musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.611229 REST_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-6984-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TG-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Activating signal cointegrator 1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.596 EMB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21926 Adrenocortical carcinoma_ACC_TCGA-OR-A5L9-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210101,GSE210114_6_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null thigh muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.458373 FOXK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.9498 myeloma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.129708 EBF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ventriculus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.104 GTEX-PVOW-2626-SM-32PL8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.16282 Metencephalon TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE120612_7_v_5_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null PMC12289921-41467_2025_62099_MOESM5_ESM.xlsx-MI-2-80-Gene_Symbol_MITF Rummagene Transcription Factor Associations 2026 1.0 null HOXD8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.4518 CRCGN012_HEPG2_24H:G05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.71307 HMY-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.922364 PC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35084 Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y8-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COLO 206F Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19465 BOLA2 Pathway Commons Protein-Protein Interactions 1.0 null GSE142210_4_v_5_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null LAMA84 CCLE Cell Line Gene CNV Profiles 1.0 1.70586 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7870-01A-11R-2232-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.294 ERC2 Pathway Commons Protein-Protein Interactions 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-4506-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null glycerol-3-phosphate dehydrogenase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.793 occipital neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.03725 MAG Pathway Commons Protein-Protein Interactions 1.0 null GSE147876,GSE147877_4_v_9_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-S32W-0926-SM-4AD5X GTEx Tissue Sample Gene Expression Profiles 1.0 0.896238 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-VB-A8QN-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Prostate sarcoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.519 mammalian phenotype MPO Gene-Phenotype Associations 1.0 null SNU16 CCLE Cell Line Gene CNV Profiles 1.0 1.45464 Lung adenocarcinoma_LUAD_TCGA-62-A471-01A-12R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DSG1 Pathway Commons Protein-Protein Interactions 1.0 null cell projection part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.044615 GTEX-TKQ1-0326-SM-4DXSM GTEx Tissue Sample Gene Expression Profiles 1.0 0.954447 GSE161846,GSE161849_3_v_0_smarca4_human RummaGEO Gene Perturbation Signatures -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-34-5236-01A-21R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 19505326-SuppTable3 GeneSigDB Published Gene Signatures 1.0 null GTEX-UTHO-2926-SM-3P5Z9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.932332 mucinoses DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.788852 SOX13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.8583 Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210101,GSE210114_6_v_10_urod_human RummaGEO Gene Perturbation Signatures -1.0 null vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.081208 SNU-668 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -3.64322 PGAM1 Pathway Commons Protein-Protein Interactions 1.0 null SKP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72408 GTEX-Q734-1126-SM-48TZY GTEx Tissue Sample Gene Expression Profiles 1.0 0.976248 GSE247084,GSE247087_0_v_1_cdyl_human RummaGEO Gene Perturbation Signatures -1.0 null STS Pathway Commons Protein-Protein Interactions 1.0 null BC-54-ON71_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.463021 Trophoblast cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.627 active GeneRIF Biological Term Annotations 1.0 null myeloma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.118994 GSE210101,GSE210114_1_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null 496100436_FWM_no dementia_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -4.13471 male reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.231795 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DR-A0ZM-01A-12R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OTX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4249 RREB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 119.545 TEAD4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZN-2126-SM-4DXU1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06258 HRNR Pathway Commons Protein-Protein Interactions 1.0 null 20860821-TableS5 GeneSigDB Published Gene Signatures 1.0 null Brain - Hypothalamus GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.611356 lymphnode_5b HPA Tissue Sample Gene Expression Profiles -1.0 -1.16949 Pancreatic adenocarcinoma_PAAD_TCGA-OE-A75W-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE195559_8_v_4_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.45193 LC-12-VN85_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.453193 PMC4387713-supp_gad.255984.114_Table_S4.xlsx-S4A-Down_Nanog_KD-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-7671-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01172 MIA PACA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.923386 GSE233049_1_v_3_atf3_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN008_HEPG2_24H:J03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.9239 CCT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91454 abnormal involuntary movement MPO Gene-Phenotype Associations 1.0 null hsa-miR-2392 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 Syndrome DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.584 AQP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30356 KNS-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.838605 XPOT Pathway Commons Protein-Protein Interactions 1.0 null GSE114013,GSE114014_0_v_3_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null PMC12827430-41467_2025_67591_MOESM6_ESM.xlsx-Supplementary_Figure_15l-FOSL2_ChIP_WT-exclusive_genes_FOSL2 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN010_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.009 TLX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.548 SOX10 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.4891 Perturb_2662_KD_CBX2_SRP363588 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 12618198-Table1 GeneSigDB Published Gene Signatures 1.0 null abnormal grooming behavior MPO Gene-Phenotype Associations 1.0 null CRCGN014_HEPG2_24H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.1881 GTEX-XGQ4-1326-SM-4GIDU GTEx Tissue Sample Gene Expression Profiles 1.0 1.02244 QGY-7703 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.721 SLVL COSMIC Cell Line Gene Mutation Profiles 1.0 null BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.261201 Epithelium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.306 Bladder Urothelial Carcinoma_BLCA_TCGA-E5-A4TZ-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cingulate gyrus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.033 CRCGN008_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.83935 carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.180652 IV Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.12797 PMC4387713-supp_gad.255984.114_Table_S3.xlsx-S3A-Down_Dpy30_KD-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S7SE-0011-R7A-SM-2XCDI GTEx Tissue Sample Gene Expression Profiles 1.0 0.824323 Lung adenocarcinoma_LUAD_TCGA-78-7166-01A-12R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-W5WG-2426-SM-4LMI6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.984085 thorax TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068605 GSE128730_3_v_2_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE239844_4_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null HL60 CCLE Cell Line Gene CNV Profiles 1.0 1.76723 GTEX-S7SE-2526-SM-2XCDL GTEx Tissue Sample Gene Expression Profiles 1.0 0.915879 PMC5640240-ppat.1006668.s013.xlsx-MAX_ChIP_shEP400-1-Unnamed_6_MAX Rummagene Transcription Factor Associations 2026 1.0 null Creatine DrugBank Drug Targets 1.0 null VZ in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.24898 GTEX-UTHO-3026-SM-3GAFB GTEx Tissue Sample Gene Expression Profiles 1.0 0.863897 mitochondrion LOCATE Curated Protein Localization Annotations 1.0 null GSE135352_2_v_4_napabucasin_human RummaGEO Drug Perturbation Signatures 1.0 null SF539 CCLE Cell Line Gene CNV Profiles 1.0 1.57312 REST_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_1_v_9_palm_human RummaGEO Gene Perturbation Signatures -1.0 null PMC6932815-ppat.1007634.s011.xlsx-ST1_DGE_ELF1_lfc2_fdr05_interse-external_gene_name_ELF1 Rummagene Transcription Factor Associations 2026 1.0 null BL2264 (DOCK9) NURSA Protein Complexes 1.0 null GSE135352_6_v_4_napabucasin_human RummaGEO Drug Perturbation Signatures 1.0 null REST_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8566473-41467_2021_26653_MOESM3_ESM.xlsx-SOX2_interacting_proteins-Gene_symbol_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null GSE176008_8_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7242-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MHHCALL3 CCLE Cell Line Gene CNV Profiles -1.0 -1.78136 Noonan syndrome 5 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.044 IGHG1 Pathway Commons Protein-Protein Interactions 1.0 null ZNF675 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.128 PMC6932815-ppat.1007634.s014.xlsx-ST4_DGE_ELF1-R8AvIFN6-mock_lfc2-external_gene_name_ELF1 Rummagene Transcription Factor Associations 2026 1.0 null Cecal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.005 V, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.09736 IGBP1 Pathway Commons Protein-Protein Interactions 1.0 null TGBC11TKB CCLE Cell Line Gene CNV Profiles 1.0 1.56875 GSE118548_1_v_2_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null GATA6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.0716 Adrenal Gland GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.641933 Adrenocortical carcinoma_ACC_TCGA-OR-A5JV-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null psoas major TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.646505 UTP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6307 EYA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28402 posterior group of nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.835053 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09961 adult retina HPM Cell Type and Tissue Protein Expression Profiles 1.0 1.14787 hsa-miR-3612 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 17297478-SuppTable6 GeneSigDB Published Gene Signatures 1.0 null USF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Abdominal obesity-metabolic syndrome 1 DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.584 MYC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFK_02_183 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.64096 PGD Pathway Commons Protein-Protein Interactions 1.0 null TTC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35869 GSE142210_4_v_7_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE139455_4_v_6_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null PTPN14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13592 Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A5RJ-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IPO13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41605 Viscus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-XPVG-1826-SM-4B64X GTEx Tissue Sample Gene Expression Profiles 1.0 1.08811 EC-62-OE64_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.50262 facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.06045 hsa-miR-107 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 MOLP8 CCLE Cell Line Gene CNV Profiles -1.0 -1.40586 15897907-SuppTable5 GeneSigDB Published Gene Signatures 1.0 null central nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.825955 cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.742769 Monogenic disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.584 Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4U-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null skeletal muscle cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.495793 GSE239688_4_v_0_canagliflozin_human RummaGEO Drug Perturbation Signatures -1.0 null Leukocyte TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.033 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A3MC-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PGK1 Pathway Commons Protein-Protein Interactions 1.0 null Heart disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.055 PMC12749580-42003_2025_9274_MOESM5_ESM.xls-Supplementary_Data_2B-Supplementary_Table2B_Full_results_of_the_proteome-wide_MR_in_Ukb_ppp_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null limb TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.124151 Preadipocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.305 neoplasm GeneRIF Biological Term Annotations 1.0 null EBNA1-20929547-CHIP-SEQ-RAJI-CELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE131649_6_v_5_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null arsenic trioxide_homo sapiens_gpl201_gse48441 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC11003700-pbio.3002240.s013.xlsx-siMYCN_RNA_IMR32_48h_q_0_05_1_5-Table_S6_Genes_commonly_and_differentially_regulated_by_MYCN_and_WDR5_in_IMR32_cells_MYCN Rummagene Transcription Factor Associations 2026 1.0 null intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null DLX6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.2107 GTEX-SNOS-0626-SM-4DM5F GTEx Tissue Sample Gene Expression Profiles 1.0 0.847222 FLG2 Pathway Commons Protein-Protein Interactions 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3HV-01A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE236486_1_v_0_arnt_human RummaGEO Gene Perturbation Signatures 1.0 null SLC25A6 Pathway Commons Protein-Protein Interactions 1.0 null tardbp_19910924_hek293e_lof_human_gpl570_gds3730 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.505873 NCAPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38134 myoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.512564 GSE109140_2_v_3_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null cingulum bundle, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.73916 GTEX-N7MS-0011-R11A-SM-2HMJS GTEx Tissue Sample Gene Expression Profiles 1.0 1.22147 Acute Myeloid Leukemia_LAML_TCGA-AB-2959-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bronchus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.306 JUND CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59694 GTEX-RVPV-0011-R11A-SM-2TF6F GTEx Tissue Sample Gene Expression Profiles 1.0 1.02305 GTEX-NPJ7-0011-R11A-SM-2I3E8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.885661 GSE194396,GSE194429_1_v_0_atrx_human RummaGEO Gene Perturbation Signatures -1.0 null GSE202434,GSE202438_12_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null macromolecular complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.471208 disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.323002 connective tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.052669 PMC10746608-427_2023_709_MOESM5_ESM.xlsx-SOX2_partners-SOX2_known_protein_partners_according_to_BioGrid_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null digestive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.256902 Lung TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 HOXB6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.193 TP63 ChEA Transcription Factor Targets 1.0 null PTBP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31274 mediodorsal nucleus of thalamus_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.948755 lateral nucleus of pulvinar Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0551 PAX5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null interference GeneRIF Biological Term Annotations 1.0 null CRCGN014_HEPG2_24H:J10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.62515 AB-85-JR73_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.218471 P53-21459846-SAOS-2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE128333_2_v_1_tcf4_human RummaGEO Gene Perturbation Signatures -1.0 null CAB39 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN017_MCF10A.WT.HP_24H:I19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2035 CRCGN009_HEPG2_24H:M19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.91685 GSE139455_2_v_5_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null NFYC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.3762 PMC8384902-mmc6.xlsx-DEG_3TF_KD_unique-GeneSymbol_AR Rummagene Transcription Factor Associations 2026 1.0 null interacts GeneRIF Biological Term Annotations 1.0 null SUCLA2 Pathway Commons Protein-Protein Interactions 1.0 null GSE167474_2_v_3_naa40_human RummaGEO Gene Perturbation Signatures -1.0 null VZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.62723 CRCGN011_HEPG2_24H:M01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.02615 peripheral portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1311 GTEX-T5JC-2326-SM-32PMR GTEx Tissue Sample Gene Expression Profiles 1.0 1.0684 Lung adenocarcinoma_LUAD_TCGA-05-5429-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GLB1 Pathway Commons Protein-Protein Interactions 1.0 null kinase activity GO Molecular Function Annotations 2025 1.0 null GSE146982_7_v_1_gpd1_human RummaGEO Gene Perturbation Signatures 1.0 null membrane-enclosed lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.05534 GSE171837_0_v_2_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null transition GeneRIF Biological Term Annotations 1.0 null intracellular organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.512862 FOXF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.9377 contractile fiber part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.074941 18245496-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null thorax muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.425726 Organelle inner membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 GTEX-UPK5-0426-SM-3GAEK GTEx Tissue Sample Gene Expression Profiles 1.0 0.900412 PTPN11 Pathway Commons Protein-Protein Interactions 1.0 null MAOA Pathway Commons Protein-Protein Interactions 1.0 null cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.53216 biceps TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.528323 Head and Neck squamous cell carcinoma_HNSC_TCGA-CX-7082-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ME-31-RM40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.293102 orbital frontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.878452 ZR-75-30 COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN011_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.1307 GSE196259_2_v_3_gcm1_human RummaGEO Gene Perturbation Signatures 1.0 null disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.01174 GSE235066_4_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Lung small cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.078 Brain Lower Grade Glioma_LGG_TCGA-P5-A5F6-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6369-01A-21R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Internal male genital organ TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.0 reticulotegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.947375 CRCGN012_HEPG2_24H:G02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.38973 GSE125014_6_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null BRCA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24036 Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FS-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-A492-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1A5-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null parietal neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.10611 CFPAC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01414 ZNF24 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.546 cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 LIPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03524 SH-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null Cerebellum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.158 Organelle envelope lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.371 DPYSL2 Pathway Commons Protein-Protein Interactions 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-4507-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5891-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Lung adenocarcinoma_LUAD_TCGA-55-8619-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null l8 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.908387 PSMA1 Pathway Commons Protein-Protein Interactions 1.0 null Reticular dysgenesis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.814 Frontal lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.004 PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_CSc_vs_NB_2D_MSC Rummagene Transcription Factor Associations 2026 1.0 null Glucose metabolism disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.255 496100322_FWM_possible Alzheimer's disease_no TBI_100+_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.39212 496100367_FWM_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.07621 phosphotransferase activity, nitrogenous group as acceptor GO Molecular Function Annotations 2023 1.0 null YMB-1-E Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.85884 EBF1 ENCODE Transcription Factor Targets 1.0 null Head TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 451LU COSMIC Cell Line Gene Mutation Profiles 1.0 null TCF12_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_6_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null DNAJA1 Pathway Commons Protein-Protein Interactions 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44R-06A-41R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9692040-mmc1.xlsx-4_SAFB2_IP_significance-T_T_Gene_names_SAFB2 Rummagene Transcription Factor Associations 2026 1.0 null LGE-VZ border region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.33396 GSE216273,GSE216292_0_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null LTN1 Pathway Commons Protein-Protein Interactions 1.0 null DMS153 CCLE Cell Line Gene CNV Profiles -1.0 -2.3514 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8ZZ-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN011_HEPG2_24H:I11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.84645 496100317_FWM_no dementia_no TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.33483 PSMB5 Pathway Commons Protein-Protein Interactions 1.0 null Carbohydrate metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.272 CatSper complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.72 CRCGN014_HEPG2_3H:D06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.26925 496100496_FWM_possible Alzheimer's disease_no TBI_88_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.21151 GSE163240_3_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Autosomal recessive nonsyndromic deafness 16 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.495 parasolitary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.90146 VZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.73956 GSE210870_0_v_1_snai1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-T2IS-0011-R3A-SM-32QPB GTEx Tissue Sample Gene Expression Profiles 1.0 0.934997 Lung squamous cell carcinoma_LUSC_TCGA-21-1077-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null glycogen storage disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.106346 myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.918848 HT1080_SOFT_TISSUE CCLE Cell Line Proteomics 1.0 3.40437 vagina HPA Tissue Protein Expression Profiles 1.0 1.40979 Thalamus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.088 abnormal spatial learning MPO Gene-Phenotype Associations 1.0 null cellular_component LOCATE Curated Protein Localization Annotations 1.0 null GBX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.9272 PAFAH1B1 Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8558-01A-21R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 PANC 08.13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.837369 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70H-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN010_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.35877 GSE178714_5_v_0_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null NR4A1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.4256 20436685-ST4-2 GeneSigDB Published Gene Signatures 1.0 null YWHAZ Hub Proteins Protein-Protein Interactions 1.0 null peripheral nervous system neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.057418 Bladder GTEx Tissue Gene Expression Profiles 2023 1.0 3.13181 Prostate gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.0 Squamous Cell Carcinoma Of The Head And Neck DisGeNET Gene-Disease Associations 1.0 null ventrolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.04828 HOXD13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.82436 GSE213715_0_v_1_iqgap2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-TSE9-1226-SM-4DXTM GTEx Tissue Sample Gene Expression Profiles 1.0 0.925277 17880687-TableS3 GeneSigDB Published Gene Signatures 1.0 null esr1_21713035_mcf7_lof_human_gpl570_gds4061 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -2.62422 arcuate nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.9592 HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02323 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3X1-01A-12R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Trophoblast stem cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.163 GTEX-T6MN-2626-SM-32PMQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.861426 GSE217526_0_v_1_parthenolide_human RummaGEO Drug Perturbation Signatures -1.0 null caudal ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.14549 GAPDH Pathway Commons Protein-Protein Interactions 1.0 null Gastrointestinal tract TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 REST_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null retroparafascicular area of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.24977 GSE125014_1_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RC-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-P4PP-1526-SM-3P61M GTEx Tissue Sample Gene Expression Profiles 1.0 0.859366 GSE211262,GSE211263_2_v_1_pbrm1_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN014_HEPG2_24H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.03676 m band COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.183025 Lung squamous cell carcinoma_LUSC_TCGA-21-5784-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4994-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TLCD3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13608 HCC4011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.923386 embryonic structure TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.530298 gracile nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.27338 RCC10RGB CCLE Cell Line Gene CNV Profiles 1.0 1.95294 TUBA4B Pathway Commons Protein-Protein Interactions 1.0 null GSE147876,GSE147877_2_v_8_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PLZ6-0926-SM-3P5ZQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.84965 adrenal gland HPA Tissue Protein Expression Profiles -1.0 -1.3208 RXRA_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hamstring muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.399871 YY1 MotifMap Predicted Transcription Factor Targets 1.0 null IQCB1 Pathway Commons Protein-Protein Interactions 1.0 null GSE169356_2_v_4_ivermectin_human RummaGEO Drug Perturbation Signatures -1.0 null Gall bladder TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.067 GSE169617_1_v_2_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null WDR5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24509 dorsal motor nucleus of the vagus (vagal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.21668 bone marrow HPA Tissue Protein Expression Profiles -1.0 -1.3208 Oviductal fluid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.724 EXOC4 Pathway Commons Protein-Protein Interactions 1.0 null GSE210870_0_v_2_snai1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE102467_3_v_2_pazopanib_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney Chromophobe_KICH_TCGA-KL-8328-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN013_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.0749 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QF-01A-12R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE224096_3_v_0_cocaine_human RummaGEO Drug Perturbation Signatures 1.0 null VZ in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.24467 ZNF680 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.6143 CRCGN017_MCF10A.WT.HP_24H:M05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.32003 FGD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39675 SW780 CCLE Cell Line Gene CNV Profiles 1.0 2.6483 GTEX-UTHO-0011-R11A-SM-3GIJE GTEx Tissue Sample Gene Expression Profiles 1.0 1.30595 male reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.357058 SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.951981 GTEX-N7MS-0011-R3a-SM-33HC6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.905713 GAS8 Pathway Commons Protein-Protein Interactions 1.0 null 496100577_FWM_probable Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.30052 POU2F2 ENCODE Transcription Factor Targets 1.0 null USF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-4403-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bronchial epithelial cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.306 LB996-RCC COSMIC Cell Line Gene Mutation Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GW-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GLI2_01_143 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 0.68432 VCP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66247 EBF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.7731 Perturb_2815_KD_LSD1_SRP310243 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 forebrain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Perturb_811_KO_NRIP1_SRP327958 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.40609 anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.834973 mediodorsal nucleus of thalamus_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.08915 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5083-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3374-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mitochondrial envelope COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34954 CAND2 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN011_HEPG2_24H:D14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2291 SIN3A ENCODE Transcription Factor Targets 1.0 null LSM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40564 NR2F2 ENCODE Transcription Factor Targets 1.0 null Reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.017 Adipocyte cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.949 CDC25A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3536 LOVO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39489 PMC7247521__F6 PFOCR Pathway Figure Associations 2023 1.0 null BMS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70986 LBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.5099 rectum_8c HPA Tissue Sample Gene Expression Profiles 1.0 0.83513 POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042998 Prostate adenocarcinoma_PRAD_TCGA-HC-A6AS-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null transferred GeneRIF Biological Term Annotations 1.0 null mediodorsal nucleus of thalamus_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.32402 PDCL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1571 PMC12582692-medi-104-e45093-s001.xlsx-Table_S1-Table_S1_Genetic_instruments_of_plasma_proteins_for_MR_analysis_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null NCIH3255 CCLE Cell Line Gene CNV Profiles -1.0 -2.59447 alimentary canal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.276846 GSE103309_2_v_0_ube3a_human RummaGEO Gene Perturbation Signatures -1.0 null GSE227698_2_v_4_g0s2_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WWYW-0011-R11A-SM-3NB38 GTEx Tissue Sample Gene Expression Profiles 1.0 1.18721 PMC11354204-JCB_202308099_TableS1.xlsx-TFEB-Flag_IP-Protein_name_TFEB Rummagene Transcription Factor Associations 2026 1.0 null VZ in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10115 FSCN1 Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A71R-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210101,GSE210114_5_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null Blood TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.033 organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Sarcoma_SARC_TCGA-DX-A2IZ-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8905236-mmc2.xlsx-Table_S10-Table_S10_Differentially_regulated_genes_in_SPI1_high_vs_low_group_in_CGGA_GBM_dataset_SPI1 Rummagene Transcription Factor Associations 2026 1.0 null RCN2 Pathway Commons Protein-Protein Interactions 1.0 null loin TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.199463 putamen, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.32469 POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-SE5C-1526-SM-4BRWU GTEx Tissue Sample Gene Expression Profiles 1.0 0.853141 psoas TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.288158 peripheral nerve sheath neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.06658 GTEX-TML8-1326-SM-4DXTO GTEx Tissue Sample Gene Expression Profiles 1.0 1.09768 reactive GeneRIF Biological Term Annotations 1.0 null PMC3226433-1756-8935-4-20-S1.XLS-Table_S5_Miz-1_KD_gene_exp_chan-Genes_up-regulated_in_Miz-1_KD_hESC_AR Rummagene Transcription Factor Associations 2026 1.0 null survival motor neuron spinal muscular atrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.608885 PAX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RBM25_02_119 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.5979 cheek TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.182845 IQGAP3 Pathway Commons Protein-Protein Interactions 1.0 null myoblast cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.188453 Brain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC12827430-41467_2025_67591_MOESM6_ESM.xlsx-Figure_4f-FOSL2_ChIP_WT-exclusive_genes_FOSL2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XOTO-2926-SM-4B65G GTEx Tissue Sample Gene Expression Profiles 1.0 0.959715 BD-18-MM33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.213204 OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.956285 SW756 COSMIC Cell Line Gene Mutation Profiles 1.0 null Cingulate cortex TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.033 Adrenocortical carcinoma_ACC_TCGA-OR-A5LH-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 NAP1L1 Pathway Commons Protein-Protein Interactions 1.0 null REST ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A5R7-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE157383_6_v_1_abemaciclib_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3440-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dlx4_00000000_mcfdash7_gof_human_gpl201_gse21657 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.311505 lateral habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.30055 ERG_01_316 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.60519 reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.05864 PMC5195898-NIHMS825571-supplement-6.xlsx-Sheet1-267_CIC_response_genes_CIC Rummagene Transcription Factor Associations 2026 1.0 null GSE146982_7_v_6_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-OHPN-0011-R11A-SM-2I5FM GTEx Tissue Sample Gene Expression Profiles 1.0 0.92662 PD-70-VS77_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.270797 CW-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null VDAC1 Pathway Commons Protein-Protein Interactions 1.0 null forelimb TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.24486 GSE82032_3_v_2_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null Allantoic fluid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.071 Leukemia DisGeNET Gene-Disease Associations 1.0 null Metabolism of amino acids and derivatives Reactome Pathways 2024 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4337-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN012_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.74417 Respiratory system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE183041_1_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE156454_0_v_1_tamoxifen_human RummaGEO Drug Perturbation Signatures -1.0 null