association dataset threshold value standardized value GSE202603_3_v_2_bhlhe40_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-UJMC-1826-SM-3GADT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.952965 POLR2A_cerebellum_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pheniramine-1992 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null naphazoline-1966 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RM-A68W-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null testosterone-2649 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MB-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.059 VZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.859312 Spinal cord TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.195 GTEX-T2IS-2626-SM-32QPP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70605 endometrium HPA Tissue Protein Expression Profiles -1.0 -0.726527 GSE206270_2_v_0_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_16563_KO_Atf4_SRP320716 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A9DE-11A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100391_FWM_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.64352 Thalamus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.201 GTEX-QVJO-1826-SM-447C9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.934621 CCRT CEM BioGPS Cell Line Gene Expression Profiles -1.0 -1.78019 eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FM-8000-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K74015591 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4939 piromidic acid-4575 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K25844701 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09497 CMT-93 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.788 Kidney Chromophobe_KICH_TCGA-KN-8429-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RBPJL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17164 cloxacillin-1443 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MDAMB231 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.13128 GSE148692,GSE148695_5_v_3_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K75815721 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53839 H3K36me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CAPAN1 DepMap CRISPR Gene Dependency 1.0 2.72311 59M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.34855 Jejunum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.219 JJ012 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.936159 OC-10-FB51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.325987 FF-28-ES17_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.34266 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6V1-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null picotamide-1387 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null DB-54-GQ68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.684352 H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PRDM5-23873026-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null NPIPB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1775 Skin epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.738 BRD-K95323025 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06377 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YL-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K63107801 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0968 GTEx Esophagus 20-29 vs 70-79 GTEx Tissue-Specific Aging Signatures 1.0 6.02273 hsa-miR-4693-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 Lateral plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.331 dorsolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.17133 Prestwick-682-4984 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K16695519 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11571 cell adhesion molecules KEGG Pathways 1.0 null BRD-K06743908 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36475 Urinary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.267 Small_Intestine-intestinal crypt stem cell of small intestine Tabula Sapiens Gene-Cell Associations 1.0 2.8147 Bicellular tight junction COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 GSE198036,GSE198041_0_v_3_sox9_mouse RummaGEO Gene Perturbation Signatures -1.0 null inner portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03278 PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-D-Enh_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-PLZ5-1726-SM-2I5F6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5229 largeintestine BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.46784 BRD-K19958830 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.93653 PROSER2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09763 TFEC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39602 seneciphylline-4822 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null primary auditory cortex (core)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.993791 Mesothelioma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.686 Prestwick-972-7266 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Chronic lymphocytic leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 sodium phenylbutyrate-502 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CLP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34448 Muscle-mesothelial cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0317432 BRD-K01639528 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21735 Epithelial to mesenchymal transition in colorectal cancer WikiPathways Pathways 2024 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6012-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K34907403 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.78219 H3K4me1_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K16754572 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56576 GTEX-S4UY-0526-SM-3K2AN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.313 ticlopidine-1975 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cell junction organization GO Biological Process Annotations 2015 1.0 null imatinib-366 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EFO-27 COSMIC Cell Line Gene Mutation Profiles 1.0 null MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.951906 Pathogenic Escherichia coli infection KEGG Pathways 2026 1.0 null inferolateral temporal cortex (area TEv, area 20)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.00674 methyldopa-1619 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6960-01A-41R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K36me3_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K28079391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22402 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H6-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medial superior olive Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.45597 clotrimazole-1549 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 17611561-SuppTable3 GeneSigDB Published Gene Signatures 1.0 null PGM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0405 MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.891325 BRD-K95338817 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07622 primary motor-sensory cortex (samples)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.70815 Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.279 GTEX-WFON-1426-SM-4LVMT GTEx Tissue Sample Gene Expression Profiles 1.0 1.29195 Zonula adherens COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.126 fludrocortisone-3785 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-REY6-0826-SM-2TF4S GTEx Tissue Sample Gene Expression Profiles -1.0 -2.17021 BRD-K75048204 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65125 SU-DHL-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17861 496100507_FWM_dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.26346 FYCO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25057 primary auditory cortex (core)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.17208 chr7_101227165_C_A_b38 GTEx eQTL 2025 1.0 2.10596 BRD-K68608492 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06587 GTEX-W5X1-0826-SM-3GILN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15412 GTEX-N7MS-0426-SM-2YUN6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.997872 Large intestine cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.606 fastigial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.21904 apical junction assembly GO Biological Process Annotations 2023 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZF-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lymphnode BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.840669 desipramine-1596 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Neoplasms CTD Gene-Disease Associations 1.0 1.23137 BRD-A15330900 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22147 CA2 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.838096 GSE213588_8_v_13_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null G44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38476 BRD-K79494396 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17507 BRD-K96779993 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.50506 Prostate adenocarcinoma_PRAD_TCGA-KK-A8IF-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cell property TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.127666 BRD-K07697589 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.45543 BRD-K87670244 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.66481 H3K27ac_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null chr7_101221253_T_C_b38 GTEx eQTL 2025 1.0 1.07666 BRD-K31616862 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18675 OE21 CCLE Cell Line Gene CNV Profiles 1.0 3.2803 SK-MEL-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.923334 bisoprolol-5348 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null FF-28-ES17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.712718 Specific developmental disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 BRD-K44427106 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50065 GSE120612_7_v_0_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null Cortical actin cytoskeleton COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.345 intercalated nucleus of medulla Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14899 small intestine GTEx Tissue Gene Expression Profiles 1.0 2.18944 cortico-medial group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.78659 Villus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.208 POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-63-A5MU-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN008_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.08615 8231_SNRPE_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.534985 NCIH2228 CCLE Cell Line Gene CNV Profiles -1.0 -1.53766 pancreas_6b HPA Tissue Sample Gene Expression Profiles -1.0 -1.21434 HEPG2 BioGPS Cell Line Gene Expression Profiles 1.0 1.07335 CRCGN008_HEPG2_24H:B07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0615 alfaxalone-3135 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null oxybuprocaine-3996 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.637594 6541_POLR2B_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.509231 CA1 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.0734 Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6088-11A-01R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.13023 7836_SF3B2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.78697 GTEX-TSE9-0011-R6A-SM-3DB7L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05521 TAL1-20566737-PRIMARY FETAL LIVER ERYTHROID CELLS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-VUSG-2226-SM-4KKZO GTEx Tissue Sample Gene Expression Profiles 1.0 0.865513 diprophylline-1853 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-PWCY-0526-SM-2I3ER GTEx Tissue Sample Gene Expression Profiles -1.0 -0.990801 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7061-11A-01R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE70935_2_v_4_cyfip1_human RummaGEO Gene Perturbation Signatures 1.0 null 6652_PPP1R10_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.18307 COV318 CCLE Cell Line Gene Expression Profiles 1.0 2.00942 2561_EIF4A3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.22917 Ileocecum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.085 ventrolateral prefrontal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.77729 corticosterone-1307 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GABP-19822575-HepG2-human ChEA Transcription Factor Binding Site Profiles 1.0 null etofylline-1409 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Cholangitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.201 ABCG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21915 KA-81-AG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.30902 nephron TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.066542 khellin-6641 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null nimodipine-5421 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE209582_1_v_0_chloroquine_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K23857235 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19883 BRD-K84688359 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16796 betahistine-4956 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null DNASE1L3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00494982 apical junction assembly GO Biological Process Annotations 2025 1.0 null alimemazine-7235 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null famotidine-2029 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 17616640-TableS3 GeneSigDB Published Gene Signatures 1.0 null GTEX-W5X1-2626-SM-4LMI8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.892263 H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PLZ5-1126-SM-3P613 GTEx Tissue Sample Gene Expression Profiles 1.0 1.6279 Sarcoma_SARC_TCGA-DX-A48R-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K92011556 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55358 GTEX-RM2N-1726-SM-2TF55 GTEx Tissue Sample Gene Expression Profiles 1.0 0.899693 Myosin II complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.424 BICR 78 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.12091 TAF1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24694 NAMALWA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17396 A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_1day-MOI-10^3_None_GSE43302 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.87553 GTEX-S7SE-0011-R10A-SM-2XCDF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.87703 primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.05857 U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.970472 Perinatal necrotizing enterocolitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.231 mdck-2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.808551 endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.06075 SBC-5 GDSC Cell Line Gene Expression Profiles -1.0 -2.28212 Gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.606 medial geniculate nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.80485 GTEX-RU72-2626-SM-4GIE1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.39856 GTEX-QLQW-1326-SM-2S1QS GTEx Tissue Sample Gene Expression Profiles -1.0 -2.23339 GSE182680,GSE182683_5_v_6_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 primary motor cortex (area M1, area 4)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.857466 AA-11-RO46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.290524 SF295 BioGPS Cell Line Gene Expression Profiles 1.0 0.915373 CRCGN016_MCF10A.TP53.M_24H:K12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.52493 NCIH1993 DepMap CRISPR Gene Dependency 1.0 6.26553 GSE226397_0_v_1_cystine_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K36me3_CH12.LX_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 6847_PSMA7_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.581694 GTEX-S7SF-1926-SM-4AT5B GTEx Tissue Sample Gene Expression Profiles 1.0 1.07833 clozapine-5226 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NF-1 MotifMap Predicted Transcription Factor Targets 1.0 null Fetal Growth Retardation CTD Gene-Disease Associations 1.0 1.31089 BRD-K11504463 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45643 MLMA COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 BRD-K08107521 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08703 scoulerine-5536 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null UF-27-HS98_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.491777 mRNA_NANOG_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null abnormal jeujunal goblet cell morphology MGI Mouse Phenotype Associations 2023 1.0 null MET_knockout_251_GDS3148 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.81957 BRD-K73556828 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42159 GSE110178_1_v_0_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-OXRP-2326-SM-2S1NL GTEx Tissue Sample Gene Expression Profiles -1.0 -2.84263 TNNT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.13726 small_intestine BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 2.2603 imatinib_homo sapiens_gpl96_gds3044 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null LY-294002-318 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Gill TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.454 Basolateral plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.314 DOT1L_DELETION_GDS4295_428_mouse_AF9 - Mixed Lineage Leukemia (MLL) cells - 7 days GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Malignant pleural mesothelioma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.695 GSE169152_3_v_7_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null cSARS Bat SRBD_12Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.57764 Rectum adenocarcinoma_READ_TCGA-EI-6514-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U3ZN-2226-SM-3DB88 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24005 GTEX-S3XE-0426-SM-3K2AC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.75134 H3K27ac_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Ovarian surface epithelial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.532 sulfadiazine-1852 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null superior frontal gyrus, right, medial bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.85958 GTEX-OXRO-1726-SM-3LK6C GTEx Tissue Sample Gene Expression Profiles 1.0 1.03314 SAP30 ENCODE Transcription Factor Targets 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5467-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.8967 nifurtimox-7328 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-XUW1-0626-SM-4BOP4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.857871 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NV-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K05640282 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32935 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.504318 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null RIPK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56617 liver HPA Tissue Protein Expression Profiles -1.0 -0.726527 GTEX-OIZI-0626-SM-2XCEH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6583 GSE144231_6_v_5_cxcr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null blebbistatin-837 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HDAC2 ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YM-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE206226_2_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null 496100611_FWM_no dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.70029 GTEX-WEY5-1326-SM-3GILS GTEx Tissue Sample Gene Expression Profiles 1.0 1.51178 Urinary tract TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 WE-48-PP43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.535952 primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.22485 oxymetazoline-2114 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null sirolimus-5602 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE146894_3_v_8_hira_mouse RummaGEO Gene Perturbation Signatures 1.0 null benzydamine-1552 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 5211181-950 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null VZ in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.861912 LY-294002-1180 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE168602,GSE168604_2_v_6_selumetinib_human RummaGEO Drug Perturbation Signatures 1.0 null enoxacin-5251 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A42H-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K19672435 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.88774 Prostate adenocarcinoma_PRAD_TCGA-KK-A8IK-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE154464_1_v_2_cdk6_mouse RummaGEO Gene Perturbation Signatures 1.0 null heart conduction disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.197766 H3K27ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K36me3_GM06990_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SIU7-0426-SM-2XCDX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.931902 lobelanidine-5080 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Adenoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.108 organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.178126 KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.90213 NCI-H2052 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18915 SK-N-SH Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.857547 heart disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.197766 BRD-K23556321 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18213 breast HPA Tissue Protein Expression Profiles -1.0 -0.876417 OCI-M1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.74498 MCF10F Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.952429 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F5-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-7660-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6871-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tight junction assembly GO Biological Process Annotations 2023 1.0 null Henles loop TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.107 Septate junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.082 cellular_component LOCATE Curated Protein Localization Annotations 1.0 null GSE206270_1_v_0_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K88613983 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12842 GTEX-TML8-0926-SM-4DXSJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.857748 GTEX-XGQ4-0126-SM-4AT4H GTEx Tissue Sample Gene Expression Profiles 1.0 1.24497 BRD-K85720719 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09862 BRD-K04546974 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34341 posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.892659 BRD-K43798660 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18054 GTEX-OHPL-1626-SM-2HMIR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16856 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4113-01A-01R-1193-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K36me3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE236502_1_v_3_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null ovary epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.36526 perhexiline-5081 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CCDC174 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.35117 TMEM221 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07632 female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.069248 periodontium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.390044 GSE166308_1_v_0_pim1_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RM2N-0926-SM-48FD1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.10743 GTEX-S32W-2026-SM-4AD6E GTEx Tissue Sample Gene Expression Profiles 1.0 0.926049 dorsolateral prefrontal cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.19999 59M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.855029 GSE110178_5_v_6_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures 1.0 null Cognition Disorders CTD Gene-Disease Associations 1.0 1.1908 UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M5-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null vancomycin-2858 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2908-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_13186_Mut_Cry2_SRP303502 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -18.1135 mRNA_SFPI1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null 496100352_FWM_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.96135 GSE159148_0_v_1_sdc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NN-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null oxolinic acid-1419 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.90944 GSE175787_13_v_7_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null dorsolateral prefrontal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.5573 integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.873172 Head kidney TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.824 Perturb_14143_KO_Cblif_ERP002279 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.56845 MYOD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.2684 fluticasone-2928 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN016_MCF10A.WT.HP_24H:G02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.38645 IPC-298 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.872158 SC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04125 ELF1 ENCODE Transcription Factor Targets 1.0 null trichostatin A-1400 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K27ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WHPG-0826-SM-3NMBF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07134 mediodorsal nucleus of thalamus_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.21881 GBP4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00545633 Liver Neoplasms CTD Gene-Disease Associations 1.0 1.61389 CRCGN015_HEPG2_48H:F01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.9858 Inner mucus layer COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.742 SF268 BioGPS Cell Line Gene Expression Profiles -1.0 -0.994336 idazoxan-6747 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null dihydrostreptomycin-2074 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Anchoring junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.8 outer CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.9942 BRD-K59523233 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12901 valproic acid-1634 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_10151_KO_SCR_SRP251223 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 13.6708 dorsolateral prefrontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.97468 POLR2A_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_10149_KO_FOXK1_SRP251223 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 Brain stem TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.049 SP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39979 GSE132948,GSE132949_0_v_5_msi2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null BRD-K67183010 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49687 GSE133691_1_v_3_lgr5_mouse RummaGEO Gene Perturbation Signatures 1.0 null colon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.502357 GSE231648_1_v_5_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null LLGL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60644 Adrenocortical carcinoma_ACC_TCGA-OR-A5JJ-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null localization GO Biological Process Annotations 2015 1.0 null QA-34-PH05_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.232315 ARHGEF17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62796 SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.08365 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-CREB3L1_CREB3L1 Rummagene Transcription Factor Associations 2026 1.0 null KE-73-XV62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.614226 androsterone-2650 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CHST4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29349 HT1080 BioGPS Cell Line Gene Expression Profiles 1.0 0.857169 GTEX-NPJ8-0326-SM-2D7VV GTEx Tissue Sample Gene Expression Profiles 1.0 1.64712 GTEX-XGQ4-1026-SM-4AT4L GTEx Tissue Sample Gene Expression Profiles 1.0 1.80435 abnormal digestive system morphology MGI Mouse Phenotype Associations 2023 1.0 null amygdaloid complex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.29961 male reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.108999 posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.60034 MPP89 CCLE Cell Line Gene Expression Profiles -1.0 -2.36139 abnormal crypts of lieberkuhn morphology MPO Gene-Phenotype Associations 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5456-11A-02R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN008_HEPG2_24H:N02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.04875 nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051968 SYS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42194 BRD-K93819193 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19545 SNU-398 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.0005 Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.91911 GTEX-Q2AI-0008-SM-48U2H GTEx Tissue Sample Gene Expression Profiles 1.0 1.07624 MAF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.057 GATA2 ChEA Transcription Factor Targets 1.0 null POLR2AphosphoS2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RFC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72842 BRD-K72835476 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48675 sirolimus_mus musculus_gpl1261_gse21755 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Catenin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.003 GTEX-TKQ1-1426-SM-4GICK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.39708 POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUYS-0326-SM-47JX2 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.75387 GTEX-NPJ8-0226-SM-48TBN GTEx Tissue Sample Gene Expression Profiles 1.0 0.90805 Pellicular membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.725 PMC11067031-pnas.2317690121.sd03.xlsx-gene_list_-_2022-04-13T081711_1-Differentially_expressed_genes_between_PML_RARA_GFP_vs_Empty_vector_GFP_mouse_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WXYG-0926-SM-3NB2O GTEx Tissue Sample Gene Expression Profiles 1.0 1.16268 GTEX-WHPG-0626-SM-3NMBD GTEx Tissue Sample Gene Expression Profiles 1.0 1.59222 NCI-H446 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.56516 GSE60217_1_v_2_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null apical complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.505537 BRD-K76008396 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0259 GSE136894_1_v_3_psen1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE229973_3_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-A20182314 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15353 superior rostral gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.62601 BRD-K70543679 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.8798 BRD-K24108193 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70859 nicergoline-2058 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null chr7_101250062_G_C_b38 GTEx eQTL 2025 1.0 1.11315 smallintestine_4d HPA Tissue Sample Gene Expression Profiles 1.0 1.38216 Edema CTD Gene-Disease Associations 1.0 1.18587 GATA1 ENCODE Transcription Factor Targets 1.0 null cerebellar cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.91548 midbrain raphe nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.981052 Ileum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.132 doxorubicin_homo sapiens_gpl570_gse46493 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Myelinating Schwann cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.737 BRD-K41355839 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03062 ATF1 ENCODE Transcription Factor Targets 1.0 null 4687_LSM12_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.533718 clemizole-4695 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null all GWASdb SNP-Phenotype Associations 1.0 0.032187 GSE190534,GSE190536_0_v_1_cyclophosphamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null red nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.875197 Lung adenocarcinoma_LUAD_TCGA-86-A4P7-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AR-20517297-VCAP-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GSE180200,GSE180201_5_v_11_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null minocycline-5496 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A4ZT-11A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KHM-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.16568 hippocampus (hippocampal formation)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.949765 KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.28722 20436685-ST4-2 GeneSigDB Published Gene Signatures 1.0 null ZFY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38066 GTEX-QESD-1626-SM-2S1RB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.72051 PRDM5 ChEA Transcription Factor Targets 1.0 null RELA_DN.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null primary auditory cortex (core)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.62637 BRD-K03188480 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42778 Mobilized_CD34_Primary_Cells_Female Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.04347 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE226114,GSE226116_1_v_0_doxorubicin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WK11-0526-SM-3NB3O GTEx Tissue Sample Gene Expression Profiles 1.0 0.905333 EP300_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LIVF001-007 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37342 Claudin InterPro Predicted Protein Domain Annotations 1.0 null Perturb_3528_KD_FTO_SRP212621 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.76354 Glucosidase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.18 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A553-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BICR31 CCLE Cell Line Gene Expression Profiles -1.0 -1.49457 adipiodone-5510 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NOTO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7661 GTEX-U3ZM-1226-SM-3DB9G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48393 GTEX-RU72-1326-SM-2TF6T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63574 19555670-Table3a GeneSigDB Published Gene Signatures 1.0 null KMS-28BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01517 Paneth cell_Intestinal crypt_Mouse CellMarker Gene-Cell Type Associations 1.0 null Cell-cell junction organization Reactome Pathways 2014 1.0 null GSE95077_1_v_3_amiloride_human RummaGEO Drug Perturbation Signatures 1.0 null locus ceruleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.05143 SNU719 CCLE Cell Line Gene Expression Profiles 1.0 1.54077 H3K36me3_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4PQ-0326-SM-2HMJ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27709 Lung adenocarcinoma_LUAD_TCGA-78-8640-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GPN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07985 hippocampus (hippocampal formation)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.52345 Common Variable Immunodeficiency DisGeNET Gene-Disease Associations 1.0 null Lung adenocarcinoma_LUAD_TCGA-91-6835-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF263_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE202434,GSE202438_9_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null sevoflurane_homo sapiens_gpl570_gds2772 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC7310421-12885_2020_7088_MOESM3_ESM.xlsx-HOXA10_methylation_DMR_exonic-exonic_DMRs_HOXA10 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-R55F-0011-R6A-SM-2TF4L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.863062 HCC1419 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.26169 Duodenum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 KDR_knockdown_119_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.91984 PMC3445581-pone.0043239.s005.xlsx-CTCF-HIFF-Gene_Symbol_CTCF Rummagene Transcription Factor Associations 2026 1.0 null BRD-K19652287 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4505 CRCGN011_HEPG2_24H:A12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.13985 Sertoli cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.894 Gastric epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.421 Perturb_3820_KO_Satb2_SRP307573 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-Normal_309_TCF7_rep1_sorted_pea-Gene_Name_TCF7 Rummagene Transcription Factor Associations 2026 1.0 null PMC12634441-41375_2025_2771_MOESM8_ESM.xlsx-ATACseq-Table_S3_Bulk_ATAC-seq_GATA2_vs_control_Only_p-adj_0_05_GATA2 Rummagene Transcription Factor Associations 2026 1.0 null primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.06798 copper sulfate-575 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-WEY5-0426-SM-3GIKT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0919 pargyline-2102 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ventrolateral prefrontal cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.3544 small intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.982386 H3K27ac_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE143743_0_v_2_c9orf72_human RummaGEO Gene Perturbation Signatures 1.0 null fluoxetine-6757 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ME-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.56894 GTEX-S4Q7-1126-SM-4AD6R GTEx Tissue Sample Gene Expression Profiles 1.0 1.03048 GSE169356_2_v_3_ivermectin_human RummaGEO Drug Perturbation Signatures -1.0 null Hepatomegaly CTD Gene-Disease Associations 1.0 1.39507 TREML1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00516773 spleen HPA Tissue Protein Expression Profiles -1.0 -2.23192 Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.516 BRD-K93846199 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52344 ANKRD46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52542 primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.02109 AP-2rep MotifMap Predicted Transcription Factor Targets 1.0 null chr7_101251416_T_G_b38 GTEx eQTL 2025 1.0 2.01026 outer portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10237 PMC8173714-NIHMS1678410-supplement-Supplementary_Table_2.xls-OfficialIPEXsig-Supplementary_Table_2_-_IPEX_signature_genes_with_their_average_IPEX_HD_fold_change_in_Tregs_and_Tconvs_FOXP3 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-4729 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 GSE168602,GSE168604_2_v_1_selumetinib_human RummaGEO Drug Perturbation Signatures 1.0 null HE-80-BQ08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.202242 GSE182680,GSE182683_5_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null plasma membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 H3K36me3_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE182680,GSE182683_5_v_11_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GSE173394_1_v_0_nfatc2_human RummaGEO Gene Perturbation Signatures 1.0 null central gray substance of midbrain, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1103 GSE48812_7_v_1_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null PPARA::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.8765 inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.07587 GTEX-XBED-0526-SM-47JY3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22134 Perturb_2950_KD_Myog_DRP004738 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.68809 PIKFYVE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31473 pralidoxime-3066 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GNLY LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00531436 GSE242290_3_v_2_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null JHH2 CCLE Cell Line Gene CNV Profiles 1.0 1.40465 HCC1833 CCLE Cell Line Gene Expression Profiles -1.0 -2.11138 smallintestine_4a HPA Tissue Sample Gene Expression Profiles 1.0 1.64491 iohexol-5704 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC4960540-srep30217-s5.xls-VD_metabolism-V_VDR_Q3_VDR Rummagene Transcription Factor Associations 2026 1.0 null GSE138019_1_v_5_nudt12_mouse RummaGEO Gene Perturbation Signatures -1.0 null GF-35-IT27_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.216027 GTEX-W5X1-2826-SM-3GILM GTEx Tissue Sample Gene Expression Profiles 1.0 1.0796 Liver hepatocellular carcinoma_LIHC_TCGA-ZP-A9D0-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.14743 Breast Neoplasms CTD Gene-Disease Associations 1.0 1.40705 BRD-K33912919 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12878 GSE148321,GSE169423_2_v_1_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-U3ZN-2126-SM-4DXU1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20593 Basal part of cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.284 rectum_8d HPA Tissue Sample Gene Expression Profiles 1.0 0.864432 BRD-K02473319 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02448 ventral posterior lateral nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.87495 RELA JASPAR Predicted Transcription Factor Targets 1.0 null Left colon TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.637 GTEX-SE5C-0626-SM-2XCDV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71316 PNU-0251126-7388 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.51639 MYH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27202 tight junction GO Cellular Component Annotations 2015 1.0 null GTEX-Q2AH-0226-SM-48U1I GTEx Tissue Sample Gene Expression Profiles 1.0 1.2733 EP300 ENCODE Transcription Factor Targets 1.0 null BICR16 CCLE Cell Line Gene CNV Profiles 1.0 1.48957 ovary HPA Tissue Protein Expression Profiles -1.0 -2.23192 u87 HPA Cell Line Gene Expression Profiles -1.0 -0.905436 Sarcoma_SARC_TCGA-DX-A6Z2-01A-12R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MS751 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.847862 DB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.05499 H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.124 9751_VPS35_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.500423 H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TMEM243 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73084 Perturb_1990_KD_Diaph2_SRP169116 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.197766 AR-20517297-VCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null benzonatate-1843 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null naftidrofuryl-1267 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null AE-42-HT01_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.247442 Lung squamous cell carcinoma_LUSC_TCGA-90-A59Q-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-1915 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 sirolimus-6967 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCIH684 CCLE Cell Line Gene Expression Profiles 1.0 2.19825 GSE184399_0_v_3_cnot1_human RummaGEO Gene Perturbation Signatures -1.0 null structural molecule activity GO Molecular Function Annotations 2015 1.0 null Goblet cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.973 NUGC-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.832699 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K36me3_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5457-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mediodorsal nucleus of thalamus_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.845044 BAG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51212 Crohn's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.879 ZNF740 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 113.257 oxetacaine-1484 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H2BK5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-U3ZN-0826-SM-4DXSZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00263 MZ in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.42952 amygdaloid complex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.14878 COLO800 DepMap CRISPR Gene Dependency 1.0 3.28463 outer SZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05151 harmine-2750 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K45717258 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.12453 DC-51-WE27_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.392326 BRD-K27354087 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30038 GSE223241_1_v_3_cdkn2a_human RummaGEO Gene Perturbation Signatures -1.0 null GSE182179_2_v_3_kdsr_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-T5JC-0626-SM-3NMA6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0251 GSE171175,GSE171181_1_v_0_e7107_human RummaGEO Drug Perturbation Signatures 1.0 null CA4 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.12586 sirolimus-6958 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MKN7 CCLE Cell Line Gene CNV Profiles -1.0 -1.33447 orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.1401 HCC2998 BioGPS Cell Line Gene Expression Profiles 1.0 2.41625 HDAC1 ENCODE Transcription Factor Targets 1.0 null GSE113106_3_v_4_dnm2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Pancreatic juice TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.52 HS 695T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.96981 VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.83085 GTEX-V955-0726-SM-3GAFG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00809 MZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04509 pridinol-3456 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null WHSC1 ENCODE Transcription Factor Targets 1.0 null 938_BUD31_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.566527 SLC41A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66496 BRD-K19266588 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03992 SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T2YK-0326-SM-4DM7D GTEx Tissue Sample Gene Expression Profiles 1.0 1.88241 PMC6879454-Data_Sheet_1.xlsx-AA_disease-Unnamed_4_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OXRP-0526-SM-2I3EW GTEx Tissue Sample Gene Expression Profiles 1.0 1.11384 enlarged ileum MPO Gene-Phenotype Associations 1.0 null Skin disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.128 Slit diaphragm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.713 supramammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.32967 epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.486326 GSE89729_0_v_1_ppard_human RummaGEO Gene Perturbation Signatures -1.0 null MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R3RS-0526-SM-3GADG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07054 PMC4387713-supp_gad.255984.114_Table_S4.xlsx-S4B-Up_Nanog_KD-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null altretamine-5688 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null VZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16107 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 CRCGN010_HEPG2_24H:H08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.93598 MYC-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-SNOS-1526-SM-32PLW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29975 ELF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59324 SA-32-CC58_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.835602 cingulum bundle, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.06616 BRD-K05699155 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57154 Breast disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.238 Mucus layer COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.756 NCI-H596 GDSC Cell Line Gene Expression Profiles -1.0 -1.5455 amygdaloid complex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.48994 adrenal gland GTEx Tissue Gene Expression Profiles -1.0 -0.848486 GTEX-XQ8I-1726-SM-4BOQB GTEx Tissue Sample Gene Expression Profiles 1.0 1.80522 Perturb_3222_KO_Nhe1_SRP366933 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.12897 BRD-K08828851 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17235 GSE107854_2_v_0_prmt5_mouse RummaGEO Gene Perturbation Signatures -1.0 null 6455_PLK4_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.554608 cell junction LOCATE Curated Protein Localization Annotations 1.0 null PRC_DEPLETION_GDS3532_96_human_U2OS cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null T-47D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18995 viscus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Colon TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.113 CDCA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39502 GTEX-S4P3-1626-SM-3K2AZ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.57922 TAL1 ChEA Transcription Factor Targets 1.0 null 7-aminocephalosporanic acid-4826 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null identical protein binding GO Molecular Function Annotations 2015 1.0 null GSE111035,GSE111040_8_v_9_plag1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BC-10-SB73_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.627354 RC-K8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04125 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null cell-cell junction LOCATE Curated Protein Localization Annotations 1.0 null GTEX-VUSG-2326-SM-4KL1U GTEx Tissue Sample Gene Expression Profiles 1.0 0.835968 Lateral ventricle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-A5NI-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE158834_0_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null GSE159893_2_v_1_genistein_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN014_HEPG2_3H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.6387 heart conduction disease GWASdb SNP-Disease Associations 1.0 1.14463 Autoimmune disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.723 BRD-K90408478 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07742 Bile canaliculus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.514 inferolateral temporal cortex (area TEv, area 20)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.11237 Prostate adenocarcinoma_PRAD_TCGA-VP-A878-01A-31R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EEF1G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 9.0061 BRD-K24047785 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06911 GSE144231_3_v_5_cxcr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null cinchonine-2789 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Brain ventricle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GSE110178_2_v_0_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures 1.0 null BRD-K01077691 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21982 ZNF496 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32661 piretanide-6828 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null sertoli cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.590839 GSE233647_2_v_3_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null GSE174498,GSE174500_0_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null oxybuprocaine-1476 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MRK-NU-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K48592348 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58202 Lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.176 RBM27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00282 3986_HSPE1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.650144 BRD-K38197770 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46765 suramin sodium-7524 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CAPAN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.91945 H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7469-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ovarian cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.093103 bicellular tight junction assembly GO Biological Process Annotations 2025 1.0 null BRD-K76329122 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46617 BRD-K84518331 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31454 amitriptyline-1865 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A ENCODE Transcription Factor Targets 1.0 null PD-05-HV36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.212519 GTEX-T6MN-0011-R10A-SM-32QP7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.846171 GTEX-QESD-0526-SM-2I5G5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30578 TestisIntersitial BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.10946 H3K27ac_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Insect tracheal system TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.786 GSE111247_2_v_6_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE241622_1_v_0_ythdc2_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN008_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.6266 MRPL30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55379 niflumic acid-5490 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null hippocampus (hippocampal formation)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.944174 CRCGN015_HEPG2_48H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.56867 GTEX-OOBJ-1026-SM-3NB2L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.848884 ventrolateral prefrontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.0478 urinary system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Apical junction complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 hippocampus (hippocampal formation)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.35796 H3K36me3_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO Biological Process Annotations 2025 1.0 null bicellular tight junction GO Cellular Component Annotations 2025 1.0 null GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null LS-411N COSMIC Cell Line Gene Mutation Profiles 1.0 null tight junction KEGG Pathways 1.0 null GTEX-Q2AG-0426-SM-2S1PU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00887 COLO 680N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08783 Fetal_Intestine_Large Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.52449 hsa-miR-4749-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 Connecting tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.645 viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.70886 BRD-K51323894 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.97394 8190_SMU1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.742962 Ovarian disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.123 pyrithyldione-2740 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060569 H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HEY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.936159 BRD-K60454848 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07306 PRDM8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32539 GSE182680,GSE182683_5_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null MCAS COSMIC Cell Line Gene Mutation Profiles 1.0 null RBPMS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91366 RPL27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02867 dorsal motor nucleus of the vagus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.28119 H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.18151 4950_MED27_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.797836 amygdalohippocampal transition zone, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.845207 gastrointestinal tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.949962 PANK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19398 BRD-K61533770 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58275 GSE216043_3_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K71817857 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16331 tooth disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.386679 NCI-H23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.854292 nimesulide-2275 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MAZ_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4XX-0011-R2A-SM-3P623 GTEx Tissue Sample Gene Expression Profiles 1.0 0.90709 Lung squamous cell carcinoma_LUSC_TCGA-56-7580-11A-01R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null crypt TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.05237 planum temporale, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.24367 Mesothelioma_MESO_TCGA-MQ-A6BQ-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K03015524 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34106 PMC7606598-NIHMS1624889-supplement-1624889_Supp_Tab1-10.xlsx-S8_MR-JTI-geneid_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null HL60 BioGPS Cell Line Gene Expression Profiles 1.0 1.34341 GTEX-Q2AI-1526-SM-3GIJ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06712 Diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.254 Lamina propria TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.718 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4857-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE111247_2_v_8_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE68156_3_v_4_dextran_mouse RummaGEO Drug Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A74Q-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE114992,GSE114993_0_v_5_irf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null Colonic mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.546 GSE133213_10_v_3_znrf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null OVCAR4 CCLE Cell Line Gene CNV Profiles 1.0 1.6604 FB-67-PL18_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.20451 FA-88-II68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.676694 GABPB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8996 testis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.177638 BRD-K04147413 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0675 EB2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.19326 risperidone-7449 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE68156_0_v_1_dextran_mouse RummaGEO Drug Perturbation Signatures 1.0 null MZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.64002 Foxn1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 14.9028 NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.36852 GSE110038,GSE133995_3_v_0_hic1_mouse RummaGEO Gene Perturbation Signatures -1.0 null HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.832699 BRD-K49872883 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03079 lung cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.058776 cerebellar cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.08834 GSE244710_1_v_2_srsf1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-P78B-0426-SM-2I5F5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.842158 BRD-K94657740 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7173 DENND11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91305 USF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletalmuscle_d HPA Tissue Sample Gene Expression Profiles -1.0 -1.42991 GTEX-XOT4-0826-SM-4B66Y GTEx Tissue Sample Gene Expression Profiles 1.0 2.73508 colon sigmoideum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.628293 Oral mucosa TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 H3K27ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K57879743 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13632 inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.89639 CL11 CCLE Cell Line Gene CNV Profiles 1.0 1.39837 CTCF MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-U3ZH-1626-SM-3DB74 GTEx Tissue Sample Gene Expression Profiles 1.0 1.14763 Cell-Cell communication Reactome Pathways 2024 1.0 null ceftazidime-1721 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Urothelial carcinoma_Urothelium_GSE3167 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.56746 SCC4 CCLE Cell Line Gene CNV Profiles 1.0 2.59496 H3K36me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 17555561-Table1 GeneSigDB Published Gene Signatures 1.0 null small intestine epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.192444 enlarged ileum MGI Mouse Phenotype Associations 2023 1.0 null alpha-estradiol-1151 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45W-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Gastrointestinal endocrine cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.454 K562_Disulfiram_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0158984 GTEX-QMRM-0526-SM-2I5GA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4003 GTEX-S33H-0326-SM-4AD6N GTEx Tissue Sample Gene Expression Profiles 1.0 1.17222 GSE203308_15_v_3_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PPP1R1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5576 Stratum granulosum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.123 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.58524 Rectal cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.81 GTEX-O5YT-1326-SM-3MJGR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.893373 DPY-21335234-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K54660148 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56849 primary visual cortex (striate cortex, area V1/17)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.49708 GSE132948,GSE132949_0_v_3_msi2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CCNH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13164 mRNA_KLF4_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GSE164529_0_v_3_tamoxifen_human RummaGEO Drug Perturbation Signatures 1.0 null SU-DHL-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30925 GTEX-WH7G-0426-SM-3NMBJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.970196 H4K20me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Gut mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.331 GSE111247_2_v_7_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null wortmannin-506 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A619-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Urinary system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 long qt syndrome GWASdb SNP-Disease Associations 1.0 1.14463 Subapical complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.331 GSE128730_0_v_2_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE111247_2_v_1_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null YY1 ENCODE Transcription Factor Targets 1.0 null integral component of membrane GO Cellular Component Annotations 2015 1.0 null UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08783 Carcinoma, Hepatocellular CTD Gene-Disease Associations 1.0 1.35012 GSE213588_9_v_4_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XUJ4-0526-SM-4BOON GTEx Tissue Sample Gene Expression Profiles -1.0 -0.91666 K562_Altretamine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0157591 BRD-K16976282 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.90948 GTEX-T8EM-1326-SM-3DB7G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22185 HARS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25295 GTEX-WRHK-1626-SM-3MJFH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24402 HCMEC/D3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.915 POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ovary adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.613965 GSE147662_0_v_1_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null cinchonidine-2772 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BABAM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23655 GSE216273,GSE216292_14_v_2_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null betulin-3513 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null III, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.81949 anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.03131 AF-10-QK79_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.208263 T3M3 DepMap CRISPR Gene Dependency 1.0 4.09615 hippocampus (hippocampal formation)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -3.16625 Seminal vesicle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Vagina TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 6460_PLRG1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.785377 GTEX-XPVG-2526-SM-4B66D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15226 BRD-K24525269 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8559 PDK1_knockout_80_GSE26290 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 0.343742 GSE241701_4_v_3_daxx_mouse RummaGEO Gene Perturbation Signatures 1.0 null abnormal small intestine morphology MPO Gene-Phenotype Associations 1.0 null gibberellic acid-4818 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null leukocyte transendothelial migration KEGG Pathways 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J9-A8CL-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_4354_KD_ERK3_SRP238353 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 GTEX-VJYA-0926-SM-4KL1N GTEx Tissue Sample Gene Expression Profiles 1.0 2.69249 alpha-estradiol-122 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me1_Adult Kidney Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EB2 CCLE Cell Line Gene Expression Profiles 1.0 1.45041 GTEX-POMQ-0326-SM-2I5FO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19254 BT-549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.03345 RD-90-OY66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.281348 UTP14A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90313 4153_INTS8_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.929698 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN017_MCF10A.WT.HP_24H:K18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.34225 cycloserine-6139 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RAD21-21589869-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE228017_0_v_1_parthenolide_human RummaGEO Drug Perturbation Signatures 1.0 null ADGRL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69737 tranylcypromine-1417 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null mRNA_NIPBL_20720539 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null XB-53-OZ95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.4548 ISTMEL1 DepMap CRISPR Gene Dependency 1.0 2.95473 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5431-01A-01R-1514-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CETN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00945 GTEX-QV31-1426-SM-2S1QD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.67674 Lung adenocarcinoma_LUAD_TCGA-69-A59K-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IgA immunoglobulin complex, circulating COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.78 YA-78-MS95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.321645 JHOS2 CCLE Cell Line Gene Expression Profiles -1.0 -1.96927 chr7_101248821_C_T_b38 GTEx eQTL 2025 1.0 2.96853 TestisGermCell BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.986617 EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.937089 VZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05637 occluding junction GO Cellular Component Annotations 2015 1.0 null GTEX-PLZ6-0926-SM-3P5ZQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.834198 NUGC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.961934 GTEX-OIZH-0226-SM-2YUMH GTEx Tissue Sample Gene Expression Profiles 1.0 1.74671 GSE196962_2_v_6_parg_human RummaGEO Gene Perturbation Signatures 1.0 null 496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.50286 GTEX-N7MS-0526-SM-4E3JP GTEx Tissue Sample Gene Expression Profiles 1.0 0.887694 PMC6684323-NIHMS1532201-supplement-Table_S6.xlsx-LPS-Sup_Table_6C_Delta_PVE_among_PopDE_genes_LPS_PopDE_FDR_0_2_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null H3K36me3_CH12.LX_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHTF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31601 PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-BrtoFay_Thermoneutral_LPS-Gene_Symbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null NEURL1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66833 internal female genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057648 GTEX-P4QS-1626-SM-2S1NH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00521 PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null Liver BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.55362 tolnaftate-1919 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null sucrase-isomaltase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.304 H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U8XE-0426-SM-3DB91 GTEx Tissue Sample Gene Expression Profiles 1.0 1.54832 Brain Lower Grade Glioma_LGG_TCGA-DU-A5TW-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5469-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GLO1_OE_GDS4991_546_mouse_anxiety disorders GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K32511780 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37522 Gut TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.867 primary auditory cortex (core)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.43122 GTEX-WY7C-0526-SM-3NB3D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22462 Sarcoma_SARC_TCGA-WK-A8XY-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-NPJ8-2526-SM-2HML8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02394 BRD-K15928912 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.96394 LGR5+ stem cell_Large intestine_Human CellMarker Gene-Cell Type Associations 1.0 null POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 4147_INTS2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.01891 chlorhexidine-6302 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cerebellar cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.995534 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-8224-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_5605_KD|OE_METTL1|RPTOR_SRP312040 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 amygdaloid complex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.939447 GTEX-PLZ4-2726-SM-3P61A GTEx Tissue Sample Gene Expression Profiles 1.0 1.12062 Peyer's gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.606 GTEX-TMZS-0326-SM-3DB9P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07687 IZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.5188 BRD-K78961368 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00297 methazolamide-6268 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K94409042 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55103 quipazine-1789 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K32403186 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0338 7837_SF3B3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.803055 HT144 DepMap CRISPR Gene Dependency 1.0 2.45846 GTEX-OHPM-1626-SM-2HMK4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60764 kanamycin-1609 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-PWN1-1426-SM-48TDF GTEx Tissue Sample Gene Expression Profiles 1.0 1.3819 BRD-K44512951 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05399 BRD-K43896262 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72017 ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RN64-0326-SM-2TC5J GTEx Tissue Sample Gene Expression Profiles -1.0 -2.35108 COLO 201 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.8734 membrane LOCATE Predicted Protein Localization Annotations 1.0 null posterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.07092 fluphenazine-5597 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K17753780 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62979 METAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95071 GTEX-QMR6-0011-R2A-SM-32PKV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12026 GSE214596,GSE214598_1_v_4_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null Nephrocalcinosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.729 dorsolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.18056 BRD-K12909905 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13235 PMC3728595-srep02327-s1.pdf-1624-ARID3A_ARID3A Rummagene Transcription Factor Associations 2026 1.0 null 496100416_FWM_dementia_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.32377 gliquidone-7301 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null lateral plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 BRD-K23670243 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30295 PMC10769314-NIHMS1954782-supplement-9.xlsx-Table_S7B-Table_S7B_Frontal_cortex_relative_gene_expression_from_post-KD_and_pre-KD_recipient_mice_AR Rummagene Transcription Factor Associations 2026 1.0 null primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.20271 GSE152432_6_v_0_zrsr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null trachea BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.873504 Apical complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.311 central nuclear group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16975 CHEK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00622784 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 propranolol-5358 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null sodium phenylbutyrate-411 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null laminin-3 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.338 KMS-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.910136 Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GU-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null diflunisal-4210 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.856412 A204 BioGPS Cell Line Gene Expression Profiles 1.0 0.982008 OVCA 429 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.878273 JHOS2 CCLE Cell Line Gene CNV Profiles -1.0 -1.5755 BRD-K49507197 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53269 PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-down-Gene_ID_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null benzthiazide-6607 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A5TR-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PB-09-OE00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.526102 PMC8143797-elife-62857-fig3-data2.xlsx-DEgenes_SW872_TAZ-CAMTA1_vs_EV-Gene_CAMTA1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-Q734-0726-SM-48TZP GTEx Tissue Sample Gene Expression Profiles 1.0 1.74398 GSE217694_4_v_0_pold1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE93309_1_v_4_prmt1_mouse RummaGEO Gene Perturbation Signatures 1.0 null NR2C2 JASPAR Predicted Transcription Factor Targets 1.0 null 496100407_FWM_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.08102 H3K36me3_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null UACC-257 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Female reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.179 dapsone-1827 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Prostate adenocarcinoma_PRAD_TCGA-YL-A8HO-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JUND ENCODE Transcription Factor Targets 1.0 null GTEX-T2IS-2026-SM-4DM6W GTEx Tissue Sample Gene Expression Profiles 1.0 1.08002 BRD-K25193509 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25535 diphemanil metilsulfate-1994 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HU-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S7SF-2026-SM-3K2AS GTEx Tissue Sample Gene Expression Profiles -1.0 -2.11574 Peritoneal mesothelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.013 TA-34-CK62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.523019 NCVADR RES BioGPS Cell Line Gene Expression Profiles -1.0 -0.952723 BRD-K35429561 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11116 BRD-K81606899 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.60979 BRD-K70518736 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30409 Lymphocytic leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 VZ in midcingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.31584 H3K36me3_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5890-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OVISE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.31973 KF-18-RY71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.334964 Oral epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.154 PSMB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11661 globus pallidus, internal segment, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.10035 BRD-K75688032 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15322 GSE151090_2_v_4_verteporfin_human RummaGEO Drug Perturbation Signatures 1.0 null COLO 205 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.56492 H3K4me1_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T2YK-2226-SM-32QPT GTEx Tissue Sample Gene Expression Profiles 1.0 1.42965 BRD-K02688026 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16342 prednisolone-5526 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE162688_1_v_2_pink1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Gastrointestinal tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.374 lactobionic acid-4950 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.839708 amygdaloid complex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.898654 striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.904126 Celiac disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.872 H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WFG8-0626-SM-3GILJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34063 RMUGS CCLE Cell Line Gene CNV Profiles -1.0 -1.38386 GSE186647,GSE217287_1_v_3_hnrnpc_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100514_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.49732 H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FB-49-NW04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.254822 buspirone-5343 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GK-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XMD3-2326-SM-4AT5H GTEx Tissue Sample Gene Expression Profiles 1.0 1.39454 CRCGN015_MCF10A.WT.HP_24H:K18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.53933 GTEX-OXRO-0226-SM-3LK6F GTEx Tissue Sample Gene Expression Profiles 1.0 1.19609 NEC8 GDSC Cell Line Gene Expression Profiles -1.0 -1.77107 FBXO10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05062 NCIH2066 CCLE Cell Line Gene Expression Profiles 1.0 1.53236 GTEX-O5YT-0926-SM-48TDG GTEx Tissue Sample Gene Expression Profiles 1.0 1.03131 genetic disease GWASdb SNP-Disease Associations 1.0 0.256658 KELLY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.99861 mammillary body, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.938407 primary motor cortex (area M1, area 4)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.874068 VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.58584 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-05A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dextromethorphan-2636 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TM-4 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.904 BD-49-MD69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.357701 principal sensory nucleus of trigeminal nerve, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.983532 BRD-K34977825 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.73865 ALL-PO GDSC Cell Line Gene Expression Profiles 1.0 1.84797 RCOR1 ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-V1-A8MM-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pavement epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.60893 nimesulide-1428 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null JC-06-ED36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.257379 RD-90-OY66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.36195 hippocampus (hippocampal formation)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.37641 Small_Intestine-transit amplifying cell of small intestine Tabula Sapiens Gene-Cell Associations 1.0 2.13412 CRCGN012_HEPG2_24H:G19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.19793 colecalciferol-5002 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-R55D-0626-SM-3GAD5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.841954 ZNF284 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47661 Excretory gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.24059 CALU-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18915 Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7H7-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN008_HEPG2_24H:D09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4383 KMRC20 CCLE Cell Line Gene CNV Profiles 1.0 1.47343 POLR2A_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XOTO-0526-SM-4B662 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.74746 Perturb_17446_KD_NOX4_SRP290143 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.48096 GSE234637_1_v_0_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE237053_1_v_0_comt_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-TSE9-0011-R5A-SM-3DB7J GTEx Tissue Sample Gene Expression Profiles -1.0 -0.944555 CRCGN014_HEPG2_24H:H18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.26413 Endocrine system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.307 TEAD4_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.673 ZKSCAN5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.8984 SAS GDSC Cell Line Gene Expression Profiles -1.0 -1.77563 TAF1D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53853 SK-MM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.2527 cystadenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.467306 BRD-K95422706 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06729 BRD-K01240438 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00824 EFHD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64036 K562_Curcumin_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0174955 plasma membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042874 NB7 DepMap CRISPR Gene Dependency 1.0 2.61917 emboliform nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.13495 dorsolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.83174 GSE242555_1_v_0_fn3k_human RummaGEO Gene Perturbation Signatures -1.0 null WM-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.3048 inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.02387 KLHDC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45064 Perturb_11549_KD_hNRNPK_SRP362515 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 Acute Myeloid Leukemia_LAML_TCGA-AB-2995-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE148321,GSE169423_0_v_1_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Disease of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.095 CAL-12T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.855029 OCIM1 CCLE Cell Line Gene CNV Profiles 1.0 1.79389 BRD-K26321439 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1777 UFD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4363 GSE144231_3_v_1_cxcr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE216043_3_v_6_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.113 GSE110178_1_v_7_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures 1.0 null flumequine-5104 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null abnormal intestine physiology MGI Mouse Phenotype Associations 2023 1.0 null CISD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18858 PSN1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.921774 Lung adenocarcinoma_LUAD_TCGA-44-A4SU-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S4Q7-1526-SM-3K2AG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08156 artemisinin-1714 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Carbohydrate metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.422 HEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00137 H4K20me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RAMOS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17396 Osmotic diarrhea DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.155 GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-TKQ2-0826-SM-33HB6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.81413 Hematopoietic cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.398 BRD-K31330911 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12133 BRD-K78477132 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5288 dorsolateral prefrontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.12721 SNU81 CCLE Cell Line Gene Expression Profiles 1.0 1.54106 biological adhesion GO Biological Process Annotations 2015 1.0 null IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.44242 GTEX-RTLS-2326-SM-46MUH GTEx Tissue Sample Gene Expression Profiles 1.0 0.905741 GSE139540_4_v_1_menadione_human RummaGEO Drug Perturbation Signatures 1.0 null NR4A2::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.2707 periodontitis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.507273 GSE181959_3_v_2_dextran_mouse RummaGEO Drug Perturbation Signatures 1.0 null genistein-638 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null dizocilpine-2069 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cell-cell junction COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H3K4me1_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4969-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AD-15-VR38_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.207387 LDOC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.15001 TAL1 ENCODE Transcription Factor Targets 1.0 null GRM CCLE Cell Line Gene Expression Profiles -1.0 -1.55016 REC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.861889 oral mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.51453 amprolium-4825 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-Q2AG-0011-R10A-SM-2HMLA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.826143 H3K36me3_CH12.LX_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal cell physiology MPO Gene-Phenotype Associations 1.0 null Terminal web COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.889 BRD-K78596805 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71523 cinnarizine-3175 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null primary motor cortex (area M1, area 4)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.8179 CAL-148 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04323 demecarium bromide-6269 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UPJH-0526-SM-4IHK8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.86374 GTEX-SSA3-0326-SM-32QPS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16897 gracile nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.929247 mestranol-4792 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K53624506 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00101 GTEX-RWS6-2126-SM-2XCAV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20933 BRD-K17412949 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00205 gibberellic acid-7330 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null penbutolol-3534 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CCZ1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68438 cell-cell adhesion via plasma-membrane adhesion molecules GO Biological Process Annotations 2015 1.0 null PPARG-19300518-CHIP-PET-3T3-L1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CALU-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.26964 PMC8016886-41419_2021_3630_MOESM6_ESM.xlsx-Sheet1-Table_S5_Differentially_expressed_genes_identified_between_HOXC6-low_and_HOXC6-high_expression_CRCs_using_TCGA_cohort_HOXC6 Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4983-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RET_druginhibition_184_GSE49414 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.49517 SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tardbp_19910924_hek293e_lof_human_gpl570_gds3730 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.208619 GSE206502_2_v_1_igf2bp1_human RummaGEO Gene Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-96-A4JL-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K08442552 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4404 SNU-601 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.832699 quipazine-7240 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-X261-0326-SM-3NMD4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37318 inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.879472 single-organism process GO Biological Process Annotations 2015 1.0 null plasma membrane LOCATE Curated Protein Localization Annotations 1.0 null Hic1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.2116 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5455-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null peritoneum cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.04756 abnormal small intestine crypts of lieberkuhn morphology MPO Gene-Phenotype Associations 1.0 null GSE128730_7_v_2_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null cell periphery COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE182680,GSE182683_5_v_8_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-RU1J-0826-SM-46MUU GTEx Tissue Sample Gene Expression Profiles 1.0 1.086 hsa-miR-4706 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 BRD-K82217056 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1721 nucleus of Darkschewitsch, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.093 PMC6996923-elife-46981-supp4.xlsx-KO_Up_Only_Vs_OCT4-Column_ID_POU5F1 Rummagene Transcription Factor Associations 2026 1.0 null CYLD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71427 GSE237040_6_v_3_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null ARRDC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80866 Secretory diarrhea DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.448 H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S3XE-0626-SM-4AD6B GTEx Tissue Sample Gene Expression Profiles 1.0 1.16548 GTEX-WH7G-0826-SM-4LVMR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11065 GSE213588_10_v_1_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null tranexamic acid-2085 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PBX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 48.5293 BRD-K03383196 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00117 GTEX-NPJ8-1726-SM-2YUNB GTEx Tissue Sample Gene Expression Profiles 1.0 1.48882 ramifenazone LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43255 ZNF692 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.8235 MZ in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.2569 GTEX-QLQW-0426-SM-447A7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.881576 intestinal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.869794 abnormal duodenal goblet cell morphology MGI Mouse Phenotype Associations 2023 1.0 null GTEX-PLZ4-2826-SM-3P617 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2901 BXPC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.881887 fusidic acid-2647 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-U4B1-1626-SM-3DB8N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11229 temporal pole, right, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.16475 BRD-K95927760 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30115 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO Biological Process Annotations 2015 1.0 null binding GO Molecular Function Annotations 2015 1.0 null DIXDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55205 PL-21 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.92753 GSE211128_3_v_6_angptl4_human RummaGEO Gene Perturbation Signatures 1.0 null EPLC272H CCLE Cell Line Gene CNV Profiles 1.0 2.13975 raubasine-1748 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ovarian carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.197742 intrinsic component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.101657 CEBPB ENCODE Transcription Factor Targets 1.0 null paracentral lobule, posterior part, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.69224 GTEX-QCQG-1626-SM-48U26 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07509 Skin Cutaneous Melanoma_SKCM_TCGA-GN-A262-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE209601_0_v_1_mef2a_human RummaGEO Gene Perturbation Signatures -1.0 null lymecycline-3514 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XV7Q-0126-SM-4BRVK GTEx Tissue Sample Gene Expression Profiles 1.0 1.0882 Perturb_14227_KO_Lsd1_SRP064569 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 GTEX-P4QT-1426-SM-3NMCX GTEx Tissue Sample Gene Expression Profiles 1.0 1.89023 GSE147056_0_v_1_actl6b_mouse RummaGEO Gene Perturbation Signatures -1.0 null CA1 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.0796 mRNA_DNMT3B_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null GTEX-XMK1-1726-SM-4B64Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.27443 BRD-K90736603 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3789 H3K36me3_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-A2J0-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Autosomal recessive nonsyndromic deafness 29 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.656 Intestinal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.851 BRD-K91470977 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27511 BRD-K47417426 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09766 cerebellar cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.07191 H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:D18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.83386 amygdaloid complex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.88405 sulpiride-1967 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null membrane part GO Cellular Component Annotations 2015 1.0 null BRD-K48764596 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07422 BRD-K13196166 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27442 POLR2AphosphoS5_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mRNA_MYCN_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null KLM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.11118 BRD-K11979048 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20199 Perineurium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.58 H3K36me3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZF-1526-SM-3MJGY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00694 ZNF416 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.4377 GTEX-TML8-1826-SM-32QOR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.77246 GSE140936,GSE140938_0_v_1_slfn11_human RummaGEO Gene Perturbation Signatures -1.0 null metamizole sodium-6030 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE110178_5_v_7_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures 1.0 null OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.899165 BRD-K08241590 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13708 BRD-K10058823 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5048 ZNF189 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.3722 GTEX-X88G-0226-SM-4GIE4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.981594 k562 HPA Cell Line Gene Expression Profiles 1.0 1.0313 BRD-K49849398 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09648 Glomerular endothelium fenestra COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.655 GTEX-XAJ8-0226-SM-4GIB2 GTEx Tissue Sample Gene Expression Profiles 1.0 2.09999 H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K54212583 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05771 RAJI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.31613 PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2 Rummagene Transcription Factor Associations 2026 1.0 null GSE198165,GSE198166_6_v_2_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null prednicarbate-5119 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.12403 orbital frontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.09686 BRD-K93357133 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39461 GSE201217_4_v_6_usf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null naproxen-1869 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung adenocarcinoma_LUAD_TCGA-95-7944-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4696 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.89817 clebopride-5412 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN014_HEPG2_3H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.06084 abnormal gland morphology MPO Gene-Phenotype Associations 1.0 null Brush border membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.497 primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.841354 DYNLRB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03039 GTEX-X4XX-1126-SM-3NMBY GTEx Tissue Sample Gene Expression Profiles 1.0 1.29605 inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.18238 PPARGC1A_KO_GDS2391_299_mouse_brain striatum GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null thioperamide-5270 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null XC-81-LR46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.355798 GTEX-WEY5-0226-SM-3GIKN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.903901 TMEM201 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67941 CEBPB_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100337_HIP_possible Alzheimer's disease_no TBI_100+_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.10619 Pleural disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.539 inferior nucleus of pulvinar Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.866 GSE110178_2_v_7_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures -1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A700-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.88572 clozapine-2644 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BB-93-VT73_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.356205 rosiglitazone-5593 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K27me3_CD14-positive monocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Connexin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.83 nitrofural-5321 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HR-01A-21R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-UJHI-1126-SM-4IHLN GTEx Tissue Sample Gene Expression Profiles 1.0 1.62536 PA-TU-8902 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.911555 GSE213588_8_v_12_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-UTHO-2726-SM-4JBH9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04268 BRD-K58607444 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51919 cinoxacin-3463 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_130_KD_Tcf7l2_SRP100171 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.46102 benfluorex-6727 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cellular component organization or biogenesis GO Biological Process Annotations 2015 1.0 null ventrolateral prefrontal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.92736 H3K79me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE247862,GSE247863_2_v_3_eomes_mouse RummaGEO Gene Perturbation Signatures -1.0 null (-)-atenolol-6725 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null IX, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.908352 GTEX-XQ8I-0726-SM-4BOPU GTEx Tissue Sample Gene Expression Profiles 1.0 1.26226 BRD-K07035171 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02516 COLO205 BioGPS Cell Line Gene Expression Profiles 1.0 1.13739 GTEX-QLQ7-0526-SM-2I5G3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38144 GSE120756_2_v_9_tet2_human RummaGEO Gene Perturbation Signatures 1.0 null PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA Rummagene Transcription Factor Associations 2026 1.0 null Sarcoma_SARC_TCGA-PC-A5DO-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver Diseases CTD Gene-Disease Associations 1.0 1.31059 CRCGN015_MCF10A.WT.HP_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.08106 GTEX-S33H-0626-SM-2XCBJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.13706 INPP4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.84442 GTEX-RUSQ-1026-SM-2TF6V GTEx Tissue Sample Gene Expression Profiles 1.0 0.945516 tetrahydroalstonine-6209 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE157960_0_v_3_progesterone_mouse RummaGEO Drug Perturbation Signatures 1.0 null MDAMB453 CCLE Cell Line Gene Expression Profiles -1.0 -1.53004 oxolamine-4969 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_14224_KO_Tcf12_SRP392331 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -9.83278 GSE198165,GSE198166_9_v_2_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE145476_2_v_0_hopx_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HT-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K25791914 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22923 BRD-K85546819 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22485 GSE169205_3_v_2_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null autosomal genetic disease GWASdb SNP-Disease Associations 1.0 0.31104 Rectum adenocarcinoma_READ_TCGA-DY-A1DF-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MRPS21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23602 primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.0845 OE33 CCLE Cell Line Gene CNV Profiles 1.0 1.92736 monogenic disease GWASdb SNP-Disease Associations 1.0 0.282366 azapropazone-6522 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-WYJK-1026-SM-3NM8W GTEx Tissue Sample Gene Expression Profiles -1.0 -0.886829 GTEX-O5YT-1626-SM-32PK6 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.43207 Lung adenocarcinoma_LUAD_TCGA-93-A4JQ-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9882185-media-4.xlsx-Neuron_KD-ID_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null 496100396_HIP_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.14984 CHD2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K63242692 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27769 POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K30611309 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12888 TF-77-DW08_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.244723 PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF-_SURVIVAL-hugo_id_MITF Rummagene Transcription Factor Associations 2026 1.0 null Colorectal cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.802 Rectum adenocarcinoma_READ_TCGA-EI-6509-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K85532500 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33766 perphenazine-2040 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_HEPG2_48H:J24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.34082 abnormal enterocyte cell number MGI Mouse Phenotype Associations 2023 1.0 null Duodenum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.041 Small intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.427 H3K36me3_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K40418847 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7209 GTEX-WFON-0126-SM-4LVM9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.31699 HNF4A ChEA Transcription Factor Targets 1.0 null APOBEC3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51363 A-Vietnam-1203-2004(H5N1)_7Hour_None_GSE43204 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.48679 GSE144231_4_v_1_cxcr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null SOX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18567 PMC9533694-MOL2-16-3410-s013.xlsx-FIR20vsREST_DEMs-FIR20_vs_REST_DEMs_Up_REST Rummagene Transcription Factor Associations 2026 1.0 null kawain-7369 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null male reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.092157 Reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.051 Neurobehavioral Manifestations CTD Gene-Disease Associations 1.0 1.26638 DG-75 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE148692,GSE148695_7_v_0_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.332794 GSE219195_4_v_2_rbm12_human RummaGEO Gene Perturbation Signatures 1.0 null Perturb_11866_OE_Il13_ERP005901 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -9.55718 CRCGN011_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.4677 GSE148695,GSE167281_0_v_1_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3R5-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FSCN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82383 Perturb_10390_KD_TP63_SRP273737 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.06566 GTEX-XUJ4-0226-SM-4BOP8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.909417 MKN-28 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.708 GTEX-X585-1226-SM-46MW7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04592 GTEX-XYKS-2526-SM-4BOPX GTEx Tissue Sample Gene Expression Profiles 1.0 1.12801 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NO-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.06445 SNU-484 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.921774 biperiden-4684 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HB-06-WU12_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.339581 GTEX-TSE9-0011-R10A-SM-3DB7O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08888 MZ in posteroventral (inferior) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.981635 Fibre tract TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.049 protein binding GO Molecular Function Annotations 2015 1.0 null DB-21-FY75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.600358 pioglitazone-7506 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K51160592 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46813 trimetazidine-1727 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K20053005 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40711 sirolimus-5239 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null renal proximal tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.320227 skeletal muscle HPA Tissue Gene Expression Profiles -1.0 -1.99351 Intestinal infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.057 Eye TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.074 BB-87-SF89_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.213163 PRKAG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64943 soft tissue HPA Tissue Protein Expression Profiles -1.0 -1.5797 salsolidin-2824 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null UBTF ENCODE Transcription Factor Targets 1.0 null GSE110178_4_v_3_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-RWSA-0526-SM-2XCBC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09044 ZNF454 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 147.7 GSE245134_2_v_3_atg5_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE151612_4_v_8_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null TLCD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10974 KMS-12-BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09362 Gastrointestinal system benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.015 paraventricular nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.34645 SRC_activemutant_51_GSE15815 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.61006 EIF3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53004 CiliaryGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.62447 cell-cell junction GO Cellular Component Annotations 2025 1.0 null Columnar cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.092 20436685-ST5-2 GeneSigDB Published Gene Signatures 1.0 null Cell Transformation, Neoplastic CTD Gene-Disease Associations 1.0 1.09576 intrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null GSE128730_4_v_5_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H378 GDSC Cell Line Gene Expression Profiles -1.0 -1.44849 laudanosine-7270 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K11671824 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39879 TSG101 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98289 etiocholanolone-6060 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE136894_2_v_3_psen1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OHPM-1426-SM-3TW8Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.872436 GSE214685_0_v_1_nsun2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE95771_0_v_2_ruxolitinib_mouse RummaGEO Drug Perturbation Signatures 1.0 null metolazone-1932 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null R3HDM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37196 TP53INP2_KO_GSE54917_384_mouse_Quadriceps muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null DD-75-HY40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.210591 GSE63857_3_v_1_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null Intestinal epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.131 Weight Loss CTD Gene-Disease Associations 1.0 1.73618 reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064022 SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.38169 LOX IMVI BioGPS Cell Line Gene Expression Profiles -1.0 -0.906856 DMAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0347 GSE245134_0_v_1_atg5_mouse RummaGEO Gene Perturbation Signatures -1.0 null MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Colorectal adenocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.812 BRD-K23342427 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.90291 4695_LSM5_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.666834 GSE48812_8_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null TJP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17133 posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.864681 Lung adenocarcinoma_LUAD_TCGA-J2-A4AD-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null rolipram-3072 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null lung adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.205585 HMGN3 ENCODE Transcription Factor Targets 1.0 null GSE242290_1_v_0_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null dorsal thalamus_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.22133 pseudopelletierine-7184 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE114883_1_v_2_romidepsin_human RummaGEO Drug Perturbation Signatures -1.0 null N-acetyl-L-leucine-4622 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cellular process GO Biological Process Annotations 2015 1.0 null HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Colon cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.529 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EO-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Colitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.202 GTEX-PLZ5-0626-SM-2I5F8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.899516 BRD-K08300592 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10254 SKCO1 CCLE Cell Line Gene CNV Profiles 1.0 1.78151 GANC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0052147 H3K36me3_erythroblast_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null dextromethorphan-6300 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN016_MCF10A.TP53.M_24H:H10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.0691 EP300_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S3XE-0526-SM-4AD4G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.968037 NCI-H650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.14502 GSE213588_9_v_13_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null FD-91-OK66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.412485 GSE168697_0_v_1_wdr6_mouse RummaGEO Gene Perturbation Signatures 1.0 null flunisolide-6023 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MAZ_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNF4A ENCODE Transcription Factor Targets 1.0 null C32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.74551 gastrointestinal tract TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.382966 GTEX-T5JW-1126-SM-4DM5V GTEx Tissue Sample Gene Expression Profiles 1.0 1.60234 Anus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.848 KDM1A ENCODE Transcription Factor Targets 1.0 null FOXF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47277 tanespimycin-505 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MNAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46833 GTEX-U3ZG-0326-SM-47JXN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01456 BRD-K86039224 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12906 GIMEN DepMap CRISPR Gene Dependency 1.0 2.06052 proxyphylline-7290 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE180200,GSE180201_12_v_9_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null KMS-12-PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.42571 saquinavir-6246 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ramipril-7144 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null apical junction complex GO Cellular Component Annotations 2025 1.0 null SW1463 CCLE Cell Line Gene Expression Profiles 1.0 1.90775 Lung adenocarcinoma_LUAD_TCGA-97-7937-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cell-cell junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.852 Large intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.12 NCIH226 CCLE Cell Line Gene Expression Profiles 1.0 1.5875 OVCAR433 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.31529 BRD-K08618283 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19656 posteroventral (inferior) parietal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07587 BRD-K94514173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0515 squamous epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064884 BC-40-TU13_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.221495 AF-99-HA02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.804978 biological_process GO Biological Process Annotations 2015 1.0 null HEYA8 CCLE Cell Line Gene CNV Profiles -1.0 -1.4419 N6-methyladenosine-5332 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 600MPE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.544301 GSE148252_2_v_6_npas4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE57871_1_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H3-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Glucose metabolism disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.415 alprostadil-4179 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K32577562 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01323 GTEX-U3ZN-1926-SM-4DXSG GTEx Tissue Sample Gene Expression Profiles 1.0 1.00829 GTEX-U3ZN-0226-SM-3DB8D GTEx Tissue Sample Gene Expression Profiles -1.0 -0.834599 Oviduct TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.442 posteroventral (inferior) parietal cortex_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.838327 organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054281 GTEX-R55C-0326-SM-3GAF1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49389 GSE113106_3_v_5_dnm2_mouse RummaGEO Gene Perturbation Signatures 1.0 null plasma membrane part GO Cellular Component Annotations 2015 1.0 null GSE212299_3_v_0_abi3_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC5668942-supp_gr.216721.116_Supplemental_Data_S2.xlsx-Artery_Tibial_IR-TE-SRCAP_SRCAP Rummagene Transcription Factor Associations 2026 1.0 null solasodine-6025 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ME1 CCLE Cell Line Gene Expression Profiles 1.0 1.60763 naftopidil-7331 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-P44H-0011-R8A-SM-2XCEL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.895948 corbadrine-3450 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-TSE9-0011-R4A-SM-3DB7H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04399 Oxyntic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.75 YY1 JASPAR Predicted Transcription Factor Targets 1.0 null hippocampus (hippocampal formation)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.839315 tobramycin-2841 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-WFG7-0726-SM-3GIKO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46615 UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.825458 KB-46-EJ60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.208518 GTEX-RWSA-0726-SM-2XCBE GTEx Tissue Sample Gene Expression Profiles -1.0 -3.62094 abnormality of cardiovascular system physiology GWASdb SNP-Phenotype Associations 1.0 0.187027 Perturb_11915_KO_Rankl_SRP190820 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.66206 MALME3M CCLE Cell Line Gene CNV Profiles 1.0 1.40622 LP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.38626 NB6 DepMap CRISPR Gene Dependency 1.0 2.18554 Vasculature-epithelial cell Tabula Sapiens Gene-Cell Associations 1.0 0.558947 GTEX-WZTO-0011-R10B-SM-4E3KB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.975726 RCHY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01622 PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-geneSymbol_AR Rummagene Transcription Factor Associations 2026 1.0 null IM-95M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.923334 pancreas BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.864671 GSE211286_7_v_6_tcf12_mouse RummaGEO Gene Perturbation Signatures -1.0 null delsoline-6075 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GATA1_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TMMY-0126-SM-4DXTP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.975791 GSE96641_1_v_2_esrp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Rectal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.81 cinchonidine-1780 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE150349_0_v_1_msx1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QLQ7-1726-SM-2S1QQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55846 sitosterol-7332 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XMK1-2426-SM-4B66I GTEx Tissue Sample Gene Expression Profiles 1.0 1.14738 PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_up-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null tomelukast-222 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null primary visual cortex (striate cortex, area V1/17)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.17455 Daudi GDSC Cell Line Gene Expression Profiles 1.0 1.50594 H3K9ac_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NB-80-IM48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.352688 BRD-K79159743 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.93426 Prospore contractile ring COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.537 albendazole-oxide LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67291 Prestwick-642-2815 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Nutrition disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.14 KDM1A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IOSE80 BioGPS Cell Line Gene Expression Profiles -1.0 -0.89133 PRKACA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23567 ELF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.7122 cell adhesion GO Biological Process Annotations 2015 1.0 null colonrectum_d HPA Tissue Sample Gene Expression Profiles 1.0 0.920761 myelinating schwann cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.74174 triamterene-7307 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Anchoring junction COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 abnormal enterocyte morphology MGI Mouse Phenotype Associations 2023 1.0 null GTEX-OHPL-0326-SM-33HC8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.81588 nitrofurantoin-7373 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4700-01A-02R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE216043_3_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN014_HEPG2_3H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0155 Cochlear hair cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.987 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6948-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ARPC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1226 GSE71385_1_v_0_cdk8_mouse RummaGEO Gene Perturbation Signatures 1.0 null SARS-dORF6_24Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 0.901886 SW403 CCLE Cell Line Gene Expression Profiles 1.0 1.46452 regulation of intestinal absorption GO Biological Process Annotations 2025 1.0 null tight junction LOCATE Curated Protein Localization Annotations 1.0 null BRD-K59870481 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15545 SK-CO15 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.517 SIG-M5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.943305 BRD-K06619604 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.10167 Necrosis CTD Gene-Disease Associations 1.0 1.91217 H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.12017 GSE180525,GSE180528_1_v_0_tbx3_human RummaGEO Gene Perturbation Signatures 1.0 null RGM-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.614 Brain Lower Grade Glioma_LGG_TCGA-HT-8011-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SW900 GDSC Cell Line Gene Expression Profiles -1.0 -2.17396 BALL-1 GDSC Cell Line Gene Expression Profiles 1.0 1.47626 GTEX-PWOO-0526-SM-2S1Q3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.886595 GSE245390_2_v_1_acss2_mouse RummaGEO Gene Perturbation Signatures 1.0 null etiocholanolone-4764 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null sertoli cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.22348 BD-96-HO33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.407019 DOHH-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17396 HCC366 CCLE Cell Line Gene Expression Profiles -1.0 -2.21283 BRD-K11428617 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16538 MDA-MB-453 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11182 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GT-01A-12R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Squamous cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.267 PMC7603494-41467_2020_19353_MOESM6_ESM.xlsx-Ch_TCF3_up_and_binding_Overlapp-Unnamed_1_TCF3 Rummagene Transcription Factor Associations 2026 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.839315 antazoline-7128 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 17297478-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null CAOV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.50231 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HL-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-11A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K69659917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65401 central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.4145 NC-52-HX69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.225713 ZR751 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.878645 posteroventral (inferior) parietal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.55744 H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22726 GTEX-P78B-1626-SM-2S1O1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35936 GTEX-WWYW-0826-SM-3NB2X GTEx Tissue Sample Gene Expression Profiles 1.0 1.12651 Brain Lower Grade Glioma_LGG_TCGA-HW-8322-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gfi1b_OE_GDS4302_425_mouse_AMuLV (pro-B Abelson leukemia virus transformed) cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null NCI-H1048 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.849792 BRD-K07482874 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18916 CHD1 ENCODE Transcription Factor Targets 1.0 null H3K36me3_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE180200,GSE180201_3_v_9_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null HUP-T3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.921986 GTEX-U8XE-1926-SM-3DB98 GTEx Tissue Sample Gene Expression Profiles 1.0 1.73453 cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 erythromycin-6729 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.22695 PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-RELA_DN_V1_UP-Ensemble_gene_ID_RELA Rummagene Transcription Factor Associations 2026 1.0 null Wholebrain BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.8882 AHDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73785 esophagus_5b HPA Tissue Sample Gene Expression Profiles -1.0 -0.864153 GSE110178_5_v_0_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures 1.0 null Ovarian cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.12 small intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Perturb_1745_KO_Tet2/Tet3_SRP063091 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 10.4326 methacholine chloride-6248 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null OUMS27 CCLE Cell Line Gene CNV Profiles 1.0 1.4266 CAV1_KO_GDS3551_366_mouse_mouse heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null chlorpromazine-5214 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Desmosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.967 amygdaloid complex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.04315 inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.08563 GSE195713_0_v_1_lapatinib_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_793_KO_Nrip1_SRP327958 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.82611 496100484_FWM_no dementia_no TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.52855 BRD-K21897482 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.10231 rostral (anterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.46444 Bone disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.074 GSE149123,GSE149128_3_v_0_cdk7_mouse RummaGEO Gene Perturbation Signatures -1.0 null T-cell chronic lymphocytic leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 YY1 MotifMap Predicted Transcription Factor Targets 1.0 null GSE242290_1_v_10_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null LIVF001-011 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02124 GSE96641_3_v_4_esrp2_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K84388444 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.77798 BRD-K07361992 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1237 TRPV4_DEPLETION_GDS4851_89_mouse_3T3-F442A adipocytes GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4860-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null F-9 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.779 GTEX-N7MT-0726-SM-3TW8S GTEx Tissue Sample Gene Expression Profiles 1.0 1.47736 BRD-K84710243 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04627 CSNK1D LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00483972 TM-3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.458 GTEX-UPK5-1626-SM-4JBHI GTEx Tissue Sample Gene Expression Profiles 1.0 1.2288 H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-586 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 GSE158834_10_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WZTO-0826-SM-3NM8Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71607 GSE142210_2_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null MTX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5489 Filtration diaphragm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.712 Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CE-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:M17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.93584 NASH_Liver_GSE24807 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.92545 MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 431_AQR_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.60605 primary somatosensory cortex (area S1, areas 3,1,2)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.01946 todralazine-1841 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Skin-endothelial cell Tabula Sapiens Gene-Cell Associations 1.0 3.43963 BRD-K58277621 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08169 GTEX-XAJ8-0526-SM-47JYK GTEx Tissue Sample Gene Expression Profiles 1.0 2.55227 CAL29 CCLE Cell Line Gene CNV Profiles 1.0 1.98005 HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superior occipital gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.11741 POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE239578_2_v_3_cxadr_mouse RummaGEO Gene Perturbation Signatures 1.0 null AHCTF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46084 H3K4me1_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 6291_PHF5A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.60043 BRD-K56120807 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65054 GTEX-XQ3S-0426-SM-4BOOA GTEx Tissue Sample Gene Expression Profiles -1.0 -2.42548 Sarcoma_SARC_TCGA-DX-A7EM-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_13920_KD_HNRNPK_SRP312616 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 NZM42 DepMap CRISPR Gene Dependency 1.0 12.8149 SMC3-22415368-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null ISTMES2 CCLE Cell Line Gene Expression Profiles 1.0 1.81856 H3K36me3_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null enlarged duodenum MGI Mouse Phenotype Associations 2023 1.0 null inner SZ in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.86076 YD-49-HM53_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.215666 LENG8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4806 Lung squamous cell carcinoma_LUSC_TCGA-77-7142-11A-01R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF-26484167-CHIP-SEQ-BCELLS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-8673-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8791933-41598_2022_4817_MOESM4_ESM.xlsx-PAX7_down-Unnamed_1_PAX7 Rummagene Transcription Factor Associations 2026 1.0 null triamcinolone-5835 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null COV318 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.44778 BRD-K62976536 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.02274 GTEX-QMR6-0011-R8A-SM-32PKJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.886194 MOLM-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.34725 Skeletal Muscle Male Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 2.31486 SC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.878883 Brain Lower Grade Glioma_LGG_TCGA-DU-A7TA-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cerebral peduncle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.049 Duodenum Mucosa Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.44513 PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K76672835 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3824 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4714-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RNF103 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00155 Compact myelin COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.572 PMC11003700-pbio.3002240.s013.xlsx-siMYCN_RNA_IMR32_48h_q_0_05_1_5-Table_S6_Genes_commonly_and_differentially_regulated_by_MYCN_and_WDR5_in_IMR32_cells_MYCN Rummagene Transcription Factor Associations 2026 1.0 null GTEX-VJWN-0426-SM-3GIJI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.899835 CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.1879 Intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.392 cell junction COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 neuropathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.043971 GTEX-WFG8-0126-SM-4LVMH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.904634 BRD-K39548949 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.86313 Reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.153 PMC11462941-CAS-115-2947-s001.pdf-147-THAP9_THAP9 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XAJ8-0126-SM-47JYG GTEx Tissue Sample Gene Expression Profiles 1.0 1.31479 Excretory canal TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.829 ER-23166858-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K66960754 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.73213 membrane LOCATE Curated Protein Localization Annotations 1.0 null BRD-K10847374 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0107 BB-86-BE19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.416888 PMC5550424-41467_2017_212_MOESM4_ESM.xlsx-Hematlas-Genesets-ZNF257_ZNF257 Rummagene Transcription Factor Associations 2026 1.0 null inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.25281 TCF7L1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.424 Tricellular tight junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.09 inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13673 PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-RELA_DN_V1_UP-Gene_name_RELA Rummagene Transcription Factor Associations 2026 1.0 null KMS-28PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.36293 BRD-K13782363 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12878 CRCGN011_HEPG2_24H:N05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1326 PSMC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2556 female reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.061312 SW1463 GDSC Cell Line Gene Expression Profiles 1.0 3.59928 GTEX-QEL4-0626-SM-3GIJM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05828 single-organism transport GO Biological Process Annotations 2015 1.0 null UQCC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.94407 NCI-H1993 COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 CTCF ENCODE Transcription Factor Targets 1.0 null FOXA1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0055692 HEC59 CCLE Cell Line Gene Expression Profiles -1.0 -1.8432 viomycin-7278 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A430-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SJXC-0526-SM-2XCFG GTEx Tissue Sample Gene Expression Profiles -1.0 -2.29146 PB-09-OE00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.221192 deferoxamine-mesylate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38624 11229_NON-TARGETING_NON-TARGETING Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.520434 urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.332294 Renal tubular transport disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.002 MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null peripheral neuropathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.239101 Sclerosing cholangitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.298 GSE111247_2_v_13_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null hydrocortisone-6684 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cell-cell junction COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 memantine-7354 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-UPK5-2026-SM-4JBIM GTEx Tissue Sample Gene Expression Profiles 1.0 1.50158 GTEX-R55D-1826-SM-48FEF GTEx Tissue Sample Gene Expression Profiles 1.0 1.2418 Perturb_6519_KD_S100A4_SRP105051 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 8.24888 GTEX-PLZ5-1626-SM-3NB21 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04854 valproic acid-410 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.986823 GTEX-N7MS-0011-R10A-SM-2HMJK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.852131 pronetalol-7322 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null chr7_101226844_T_C_b38 GTEx eQTL 2025 1.0 1.13935 netilmicin-3524 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.852248 GTEX-R55F-0226-SM-48FCI GTEx Tissue Sample Gene Expression Profiles 1.0 1.63604 H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null mouth disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.350084 KYSE-270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.36929 PMC11933697-41467_2025_58216_MOESM8_ESM.xlsx-SD6_ATF3_EV_NS1-SYMBOL_ATF3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QEG5-0426-SM-2I5GJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71868 GSE185163_3_v_1_clic4_mouse RummaGEO Gene Perturbation Signatures -1.0 null OACP4C COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 cellular phenotype MPO Gene-Phenotype Associations 1.0 null SUM44PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -2.02712 CRCGN016_MCF10A.TP53.M_24H:I09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0163 TEAD4 ENCODE Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CX-A4AQ-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE191105_0_v_4_nat1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ae2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.971 MZ in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.834294 GSE60217_1_v_7_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 ANLN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58428 YPEL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13349 GTEX-QDVN-2226-SM-2S1PM GTEx Tissue Sample Gene Expression Profiles 1.0 0.834998 POLR1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11528 BRD-K50685439 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05686 CRCGN014_HEPG2_3H:P02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.28835 renal tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.074403 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AZ-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K79887735 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03629 GSE185519_4_v_2_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K68939871 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57227 phenazone-1989 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE148695,GSE167281_2_v_1_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null cefalotin-6079 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-OXRO-1226-SM-48TDL GTEx Tissue Sample Gene Expression Profiles 1.0 2.02943 Attention deficit hyperactivity disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 CRCGN017_MCF10A.WT.HP_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3889 NTERA2CLD1 DepMap CRISPR Gene Dependency 1.0 4.4411 Henles loop cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.567 GTEX-OXRK-1726-SM-3NB16 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07731 KM12 BioGPS Cell Line Gene Expression Profiles -1.0 -0.833885 ND-39-PO34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.262732 GSE95077_1_v_2_amiloride_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-NPJ8-2426-SM-3MJHL GTEx Tissue Sample Gene Expression Profiles 1.0 1.29524 GTEX-PVOW-0626-SM-2XCF6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.832649 POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal small intestinal villus morphology MGI Mouse Phenotype Associations 2023 1.0 null GSE48812_2_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null HNF4A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.2018 ventral posterior inferior nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.34408 2291_DNAJC17_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.76861 Nonsyndromic deafness DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.168 GSE229973_4_v_7_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE207433_0_v_1_crtc2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Jejunal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.341 ellipticine-1765 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE248634_1_v_0_gnas_human RummaGEO Gene Perturbation Signatures 1.0 null T-84 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.721 Adrenocortical carcinoma_ACC_TCGA-OR-A5JG-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ulcerative colitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.987 GSE219195_0_v_2_rbm12_human RummaGEO Gene Perturbation Signatures 1.0 null Colonic cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.812 carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.292257 Foregut TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.033 ZGLP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02258 Perturb_1729_KO_Spi1_SRP301763 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 16424041-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null Liver bud TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.545 buflomedil-4840 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4992-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K77235585 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.95548 GSE138741,GSE138743_0_v_1_lin28b_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN008_HEPG2_24H:I06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.67465 6549_POLR2H_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.604807 Gastric epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.154 anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.54274 H3K27ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EGR1 ENCODE Transcription Factor Targets 1.0 null GSE122101,GSE122103_3_v_1_ssu72_mouse RummaGEO Gene Perturbation Signatures 1.0 null isoniazid-2083 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13894 BRD-K64804596 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50246 Liver hepatocellular carcinoma_LIHC_TCGA-FV-A3R3-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 5016_MFAP1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.573064 urinary system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.345928 K562_BMS-911543_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0159615 GSE130217_5_v_3_sesn2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WHWD-0826-SM-3LK6R GTEx Tissue Sample Gene Expression Profiles 1.0 2.39726 BRD-K89515752 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.88899 GTEX-X5EB-1626-SM-4E3IV GTEx Tissue Sample Gene Expression Profiles 1.0 3.52008 skimmianine-6242 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MM.1S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.837809 Spz1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.0833 triprolidine-7248 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null mRNA_DPPA5A_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null semustine-7540 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Rapamycin vs Ctrl Exp2 MEFs (Mouse) [21659605] SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs -1.0 null BRD-K95147720 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19212 BRD-K30111752 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09873 heptaminol-6015 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ventral posterior medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.76866 CEBPD_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZFHX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.97921 GSE203308_7_v_0_brf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Small intestine epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.126 GTEX-RUSQ-2026-SM-4GIAK GTEx Tissue Sample Gene Expression Profiles 1.0 1.22789 ATF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pellagra DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.282 Kidney Chromophobe_KICH_TCGA-KN-8436-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posteroventral (inferior) parietal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.54456 Tight junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.99 Mucous cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.96 dobutamine-3206 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE158834_2_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null tretinoin-5208 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung adenocarcinoma_LUAD_TCGA-97-8179-01A-11R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferior rostral gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.40182 CD4+_Tcells BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.987511 hsa-miR-4789-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 flunixin-2552 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE181959_1_v_2_dextran_mouse RummaGEO Drug Perturbation Signatures -1.0 null chr7_101252653_A_G_b38 GTEx eQTL 2025 1.0 2.99721 D502MG DepMap CRISPR Gene Dependency 1.0 2.46288 tm-3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.621024 GTEX-X638-0426-SM-47JY2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.14741 TUBA1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.52636 RFC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71087 TMEM41B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04275 GSE114883_1_v_4_romidepsin_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K90311252 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11021 Microvillus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.556 Crus I, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.47216 GSE248501_1_v_0_mst1_mouse RummaGEO Gene Perturbation Signatures 1.0 null azaperone-5877 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Cell adhesion molecule (CAM) interaction KEGG Pathways 2026 1.0 null BRD-K53931904 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.40619 DCAF12L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05593 GTEX-POMQ-0126-SM-48TD6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.924678 mRNA_NR5A2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null BRD-K87126326 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06726 TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Blood TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.398 piriform cortex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.58149 Leydig cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.449 BRD-K48717228 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13823 GSE149359_2_v_0_asap2_human RummaGEO Gene Perturbation Signatures 1.0 null BHLHE40 ENCODE Transcription Factor Targets 1.0 null Cervical adenosquamous carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.325 PRKAB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25544 RUNX2-24764292-MC3T3-MOUSE ChEA Transcription Factor Targets 2022 1.0 null u26684 HPA Cell Line Gene Expression Profiles 1.0 1.22597 GSE131161_3_v_4_rarres1_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZZEF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18702 scoulerine-2891 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XUJ4-2626-SM-4BOQ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08983 GSE242290_1_v_2_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null MZ in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.16273 kidney cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.221989 BCPAP GDSC Cell Line Gene Expression Profiles -1.0 -2.09334 GSE122067_3_v_0_mtch2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_3794_KO_Rnf20_ERP123195 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 GTEX-SNMC-0126-SM-2XCFO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20766 BRD-K97452545 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76259 POLR1H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22536 respiratory system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.047116 GTEX-S32W-2326-SM-2XCAW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15647 GTEX-XLM4-1026-SM-4AT51 GTEx Tissue Sample Gene Expression Profiles 1.0 3.17755 olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.11086 TE8 CCLE Cell Line Gene Expression Profiles -1.0 -1.9839 PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF_D1_vs_D10-hugo_id_MITF Rummagene Transcription Factor Associations 2026 1.0 null GSE200430_1_v_0_sema3d_human RummaGEO Gene Perturbation Signatures -1.0 null PMC12126244-jci-135-184115-s239.xlsx-Table_3_Suppl_Fig_16-Genes_down-regulated_in_SOX9_low_tumors_744_genes_SOX9 Rummagene Transcription Factor Associations 2026 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.854103 intrinsic component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.127373 bone BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.956477 skeletalmuscle_c HPA Tissue Sample Gene Expression Profiles -1.0 -0.940609 calcium pantothenate-4775 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CAL 54 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.10824 GTEX-QCQG-0226-SM-48U28 GTEx Tissue Sample Gene Expression Profiles 1.0 1.15198 1408_CDC5L_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.0249 GSE135030_11_v_0_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_erythroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.08171 SARS-CoV_24Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.24339 sulfabenzamide-4979 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K01759041 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44579 nobox_18509161_newborn_ovary_lof_mouse_gpl1261_gds3254 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.066685 nifedipine-1814 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-OHPK-1326-SM-3MJGN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.846284 SNU-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.52842 GSE233566_1_v_2_braf_mouse RummaGEO Gene Perturbation Signatures -1.0 null 15902281-TableS1d GeneSigDB Published Gene Signatures 1.0 null abnormal intestinal epithelium morphology MPO Gene-Phenotype Associations 1.0 null BE-81-QL64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.254171 BRD-K92479346 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66359 BRD-K17749779 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20907 MEGF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62059 OVCAR8 CCLE Cell Line Gene Expression Profiles -1.0 -1.45562 BRD-K14210122 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23591 HSPD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28655 cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.04112 abnormal small intestinal villus morphology MPO Gene-Phenotype Associations 1.0 null proxymetacaine-5433 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K04441230 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10391 Leukocyte transendothelial migration KEGG Pathways 2026 1.0 null H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RNF125 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00258 GTEX-R55G-2326-SM-2TC61 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23372 isometheptene-5502 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.14815 GSE126463_5_v_3_pomalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null H3K36me3_H7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW 1463 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.30522 Perturb_14241_KO_Tet1_SRP237910 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.84517 GSE48812_4_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null DD-74-PJ26_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.269942 GTEX-S32W-1226-SM-4AD67 GTEx Tissue Sample Gene Expression Profiles 1.0 0.957554 CREB1-26743006-CHIP-SEQ-LNCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K50287215 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57092 Retina TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.074 spanning component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.246407 tiaprofenic acid-4091 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-POYW-0008-SM-48TE4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.985269 GSE158834_2_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null SC-58125-507 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEx Esophagus 20-29 vs 40-49 GTEx Tissue-Specific Aging Signatures 1.0 3.54536 GSE132948,GSE132949_2_v_5_msi2_mouse RummaGEO Gene Perturbation Signatures 1.0 null choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.852595 CCDC86 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22626 GSE256181_1_v_3_etv2_human RummaGEO Gene Perturbation Signatures 1.0 null GSE137144_4_v_0_nlrp3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRD-K18930370 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01287 FD-91-OK66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.741599 Bicellular tight junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.488 7455_RPL27_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.548887 CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AH-0526-SM-2I3ED GTEx Tissue Sample Gene Expression Profiles -1.0 -0.962634 GSE60837_0_v_3_bcl9_mouse RummaGEO Gene Perturbation Signatures 1.0 null 8109_SLC7A6OS_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.05492 GSE89767_7_v_5_cebpa_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE48812_4_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XUJ4-2026-SM-4BOOW GTEx Tissue Sample Gene Expression Profiles 1.0 1.47238 GTEX-SN8G-0326-SM-32PLG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59355 BRD-K66189308 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04644 PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-down-Symbol_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null ATOH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60143 SKOV3 BioGPS Cell Line Gene Expression Profiles -1.0 -0.963009 Glandular epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.916 GTEX-OHPK-1626-SM-2YUN3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.86989 abnormal intestine morphology MPO Gene-Phenotype Associations 1.0 null GSE216273,GSE216292_0_v_2_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null ASCC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40659 alpha-estradiol-5207 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Cell projection membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.278 H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.37924 gentamicin-7237 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GATA3 JASPAR Predicted Transcription Factor Targets 1.0 null IEC-18 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.479 posteroventral (inferior) parietal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.915919 LPS141 DepMap CRISPR Gene Dependency 1.0 4.21266 Tight junction interactions Reactome Pathways 2014 1.0 null GTEX-P4PP-1026-SM-3NM9O GTEx Tissue Sample Gene Expression Profiles -1.0 -0.876296 MYC ENCODE Transcription Factor Targets 1.0 null GTEX-XQ8I-1426-SM-4BOPW GTEx Tissue Sample Gene Expression Profiles 1.0 2.22599 BRD-K36923996 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18669 cerebellar cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.19511 RAD21-21589869-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE79291_1_v_2_streptozotocin_mouse RummaGEO Drug Perturbation Signatures -1.0 null smallintestine BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 caudal portion of VFC (area 44) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15991 alvespimycin-5573 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE157894_1_v_3_cystine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE157894_2_v_0_cystine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE133505_5_v_4_myf6_mouse RummaGEO Gene Perturbation Signatures -1.0 null ileocecum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.234878 PMC7618435-EMS211310-supplement-Table_S1.xlsx-C2-HSC_ELP_NR5A1 Rummagene Transcription Factor Associations 2026 1.0 null Microscopic colitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.525 HNF4A-19761587-CACO-2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE153443_1_v_2_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PLZ5-0006-SM-2S1NZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.24067 BRD-K61161989 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08018 GTEX-XQ8I-0626-SM-4BOPT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.831512 GTEX-WFG7-2226-SM-3GIKP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28135 clorgiline-5005 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC7608835-aba3058_Table_S5.xlsx-RING1B_EWS-FLI1_REPRESSED-RING1B_EWSR1-FLI1_repressed_genes_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null Colorectal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.607 GSE205976,GSE205978_1_v_4_cep83_human RummaGEO Gene Perturbation Signatures -1.0 null dihydroergotamine-mesylate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.18881 GSE228181_4_v_1_idh1_mouse RummaGEO Gene Perturbation Signatures 1.0 null orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.14396 Hepatobiliary disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.142 ODAD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56692 H3K36me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A59R-11A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 hippocampus (hippocampal formation)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.868929 H3K36me3_erythroblast_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null benign mesothelioma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.358551 NH12 DepMap CRISPR Gene Dependency 1.0 2.94646 smallintestine_4b HPA Tissue Sample Gene Expression Profiles 1.0 1.42134 OXNAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36573 GTEX-R55G-1226-SM-48FDC GTEx Tissue Sample Gene Expression Profiles 1.0 0.905799 Kidney Chromophobe_KICH_TCGA-KN-8425-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null thioridazine-1171 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TOP2B-26459242-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-MECP2-fromNode_MECP2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OXRK-0326-SM-3NB3R GTEx Tissue Sample Gene Expression Profiles 1.0 0.906046 GTEX-NPJ8-2126-SM-3MJGK GTEx Tissue Sample Gene Expression Profiles 1.0 0.839585 Malignant mesothelioma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.437 GMEB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92552 GSE110440_2_v_3_rad21_mouse RummaGEO Gene Perturbation Signatures 1.0 null mediodorsal nucleus of thalamus_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.42385 GTEX-WFG8-1626-SM-4LVMB GTEx Tissue Sample Gene Expression Profiles 1.0 2.14056 BRD-K03662481 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68334 Thoracic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.244 LRP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08781 CEP170B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.04892 hippocampus (hippocampal formation)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.28059 GTEX-X4EP-0726-SM-3P5YJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.24291 HCC2218 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.977618 subparafascicular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03486 C-33-A COSMIC Cell Line Gene Mutation Profiles 1.0 null propidium iodide-6277 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null tight junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.59083 GGTLC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73116 BRD-K16739515 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40599 Poisoning CTD Gene-Disease Associations 1.0 1.28364 NHLF Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.858906 Zic2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.363 H3K36me3_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X5EB-2326-SM-46MW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.20096 duodenum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.663149 ELF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.6808 female reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.082291 GSE253795_1_v_0_alkbh5_human RummaGEO Gene Perturbation Signatures 1.0 null Duodenal mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.032 H3K27ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.922307 lymphnode_4b HPA Tissue Sample Gene Expression Profiles 1.0 0.960621 mediodorsal nucleus of thalamus_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.01152 VZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05704 SOX9 ChEA Transcription Factor Targets 1.0 null GTEX-RTLS-2426-SM-46MUO GTEx Tissue Sample Gene Expression Profiles 1.0 1.85731 Rectum adenocarcinoma_READ_TCGA-AG-3902-01A-01R-A32Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 978_C14ORF178_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.596806 H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SC-58125-254 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.104 GSE186647,GSE217288_11_v_7_hnrnpc_human RummaGEO Gene Perturbation Signatures 1.0 null intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 GTEX-OOBK-1626-SM-2HMKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56817 estradiol-1021 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cdx2_21074721_jejunum_epithelium_lof_mouse_gpl10773_gse23436 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.97492 adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.51611 GTEX-PX3G-1626-SM-2S1PT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.974093 HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08783 BRD-K48299239 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32645 MET_knockdown_254_GSE38343 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -0.946946 HCC1806 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.35982 PMC6293073-LSA-2018-00153_TableS1.xlsx-A_KD_Tr_1_3_DNAm-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null Adenocarcinoma DisGeNET Gene-Disease Associations 1.0 null orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.45796 Brain Lower Grade Glioma_LGG_TCGA-HT-8013-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Mucin granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.659 lung carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.071013 OVCAR-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.82909 GSE106170_1_v_0_nap1l3_human RummaGEO Gene Perturbation Signatures 1.0 null mdck-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.26844 abnormal digestive system physiology MPO Gene-Phenotype Associations 1.0 null RAC3-21632823-H3396-HUMAN ChEA Transcription Factor Targets 2022 1.0 null budesonide-5431 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Gut cavity TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.326 BRD-K50129495 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.80052 nomifensine-7217 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-SE5C-0926-SM-4BRUF GTEx Tissue Sample Gene Expression Profiles 1.0 1.18333 Rad17 RFC-like complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.551 GSE216043_3_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GMPR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.03189 leflunomide-6102 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PK-45P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11457 BRD-K10911459 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50779 GTEX-S32W-0626-SM-2XCBG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.917224 SCC4 DepMap CRISPR Gene Dependency 1.0 2.57473 malignant mesothelioma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.143693 GSE246195,GSE246305_2_v_5_sin3a_mouse RummaGEO Gene Perturbation Signatures -1.0 null KA-75-LP02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.241973 GSE169205_3_v_8_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null Germinal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.122 GSE162688_3_v_4_pink1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-X4EO-0526-SM-3P5Z3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56042 Plagl1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.545 PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_1_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 GSE110178_1_v_6_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures 1.0 null Mouth disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.009 smallintestine_4c HPA Tissue Sample Gene Expression Profiles 1.0 1.26969 Congenital diarrhea 5 with tufting enteropathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.365 premotor cortex (area 6) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 3.34509 NUDHL1 CCLE Cell Line Gene Expression Profiles 1.0 1.36646 H3K27ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Olfactory lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.059 Apical junction complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.517 posterior (caudal) superior temporal cortex (area 22c)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.19424 HDAC6 ENCODE Transcription Factor Targets 1.0 null GSE239578_1_v_3_cxadr_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K47445962 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29906 TMEM218 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82939 H3K36me3_H7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GEMIN8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39549 BRD-K90769476 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48769 cellular component organization GO Biological Process Annotations 2015 1.0 null GTEX-XMD3-0006-SM-4AT5X GTEx Tissue Sample Gene Expression Profiles 1.0 0.922642 BRD-K44803159 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3334 ZR75B Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.918362 Perturb_3822_OE_Hras_SRP342740 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 GSE140651,GSE140653_2_v_1_med1_human RummaGEO Gene Perturbation Signatures -1.0 null Cerebral lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.059 GSE133213_6_v_1_znrf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null SARS-BatSRBD_96Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.18144 chlorphenesin-1432 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null haloperidol-5200 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 9790_WBP11_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.517429 POLR2AphosphoS5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K74095559 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31799 GSE160817_5_v_6_slamf6_human RummaGEO Gene Perturbation Signatures -1.0 null NCI H226 BioGPS Cell Line Gene Expression Profiles -1.0 -1.14571 MCF7 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.47192 GRHL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15685 TRIM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.85592 carbinoxamine-3466 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K9ac_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-R55C-1126-SM-48FCJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.957704 KD DepMap CRISPR Gene Dependency 1.0 3.43421 alverine-1426 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null prolonged qt interval GWASdb SNP-Phenotype Associations 1.0 1.00059 20460173-ImmPortComprehensiveListofImmune-RelatedGenes GeneSigDB Published Gene Signatures 1.0 null BRD-K68667113 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32025 GSE172494_3_v_1_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null YD-49-HM53_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.222565 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5454-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Colonic adenocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.813 BA-19-VU85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.231281 pentamidine-2834 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6VC-01A-23R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null periodontal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.433772 CRCGN015_HEPG2_48H:I06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.05648 hydralazine-4746 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.17586 Acquired metabolic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.314 fertilizedegg BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.23083 GSE236497,GSE236500_1_v_0_pemrametostat_human RummaGEO Drug Perturbation Signatures 1.0 null inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04355 BRD-K92700781 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28075 786 BioGPS Cell Line Gene Expression Profiles -1.0 -0.868031 TE-11 GDSC Cell Line Gene Expression Profiles -1.0 -1.80835 muscle GTEx Tissue Gene Expression Profiles -1.0 -1.70792 RBBP5 ENCODE Transcription Factor Targets 1.0 null BRD-K14868348 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.84442 SK-MES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18995 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4988-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XQ8I-0526-SM-4BOPS GTEx Tissue Sample Gene Expression Profiles 1.0 1.05025 PKBalpha_KO_GDS1784_196_mouse_Embryonic fibroblasts (MEFs) - 24h GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null PPARG-20176806-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K29850806 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06797 GSE171837_0_v_3_bortezomib_human RummaGEO Drug Perturbation Signatures -1.0 null aminoglutethimide-7421 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLR2A_lung_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE203308_9_v_3_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K88000297 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.05234 colorectum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.514136 primary auditory cortex (core)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.48102 PPARG-19300518-3T3-L1 preadipocyte cells-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-X15G-1626-SM-3NMB3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.978068 excretory gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.34334 indapamide-3859 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung adenocarcinoma_LUAD_TCGA-55-7728-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE120612_6_v_0_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null Mesothelioma_MESO_TCGA-SC-A6LR-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE71674,GSE71676_0_v_2_cbfa2t2_mouse RummaGEO Gene Perturbation Signatures 1.0 null NENF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93238 inferolateral temporal cortex (area TEv, area 20)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.896398 FOS JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.3132 naftifine-7273 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-WFG8-2426-SM-3GILL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54795 GTEX-OHPM-0326-SM-33HCA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.964893 Sarcoma_SARC_TCGA-DX-A48O-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K00717406 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25599 CRCGN017_MCF10A.WT.HP_24H:P11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.6642 dentate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2321 Respiratory system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.238 Kidney Chromophobe_KICH_TCGA-KN-8431-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE157594_6_v_2_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null BRD-K15373812 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08989 carcinine-4225 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-UPIC-0726-SM-3GADW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.830061 OCI-AML3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.873865 supraoptic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.860108 H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FGFR1_knockdown_94_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.91704 GSE165682_2_v_5_ptbp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN012_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.31055 fluticasone-4011 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null troglitazone-5229 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MAFA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.0994 Adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.445 PMC12585103-pbio.3003444.s013.xlsx-List_of_genes_for_GO_analysis-List_of_genes_undergoing_significant_MXE_upon_PRMT5_KD_under_hypoxia_AR Rummagene Transcription Factor Associations 2026 1.0 null OV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.68162 FAM111B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.0549 GTEX-S4Z8-0226-SM-4AD5K GTEx Tissue Sample Gene Expression Profiles 1.0 0.826703 GSE185519_3_v_2_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE217132_0_v_1_pfkfb4_human RummaGEO Gene Perturbation Signatures -1.0 null valproic acid-5237 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ovary epithelial cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.195183 NR4A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22476 AGL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.9536 Rectum adenocarcinoma_READ_TCGA-DY-A1DD-01A-21R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RUSQ-0126-SM-47JWV GTEx Tissue Sample Gene Expression Profiles 1.0 1.62276 H4 neuroglioma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.633 RPL37A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13134 atractyloside-3435 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null urapidil-6455 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null enoxacin-4655 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PE/CA-PJ15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.37384 CRTC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16148 miconazole-1896 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Gingival epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.882 GSE179031_0_v_2_foxp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PXMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05473 GTEX-S7SF-0526-SM-3K2BC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1299 928 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.981653 Pseudopodium membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.363 496100543_FWM_probable Alzheimer's disease_TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.59271 OCI-M2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.912605 GTEX-V955-2526-SM-4JBJG GTEx Tissue Sample Gene Expression Profiles 1.0 1.43026 Abnormalities, Drug-Induced CTD Gene-Disease Associations 1.0 1.13758 Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F7-01A-11R-A084-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QDVN-0326-SM-2I3FS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.871976 articaine-7272 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HCC1143 CCLE Cell Line Gene CNV Profiles -1.0 -1.47564 VIIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04919 RBBP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58804 GTEX-T5JW-1826-SM-3GAE1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1354 BRD-K23591737 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08879 PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-3_E2F2-Gene_E2F2 Rummagene Transcription Factor Associations 2026 1.0 null H3K36me3_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZH-0926-SM-48TBR GTEx Tissue Sample Gene Expression Profiles 1.0 1.63614 PMC12224929-ADVS-12-2416784-s006.xlsx-DEG_circGLIS3_KD-Unnamed_6_AR Rummagene Transcription Factor Associations 2026 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A7TD-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE165122_2_v_1_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null PMC11932929-41388_2024_3264_MOESM4_ESM.xlsx-p_0_05_FC_0_5_n_675-Differentially_expressed_genes_in_MCF7_AR-isolated_BCSCs_after_4_days_GSK591_500nM_AR Rummagene Transcription Factor Associations 2026 1.0 null CHD2 ENCODE Transcription Factor Targets 1.0 null GTEX-R53T-1326-SM-48FCQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.51785 trimethobenzamide-2002 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K77638937 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13283 H3K36me3_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TSE9-0226-SM-3DB84 GTEx Tissue Sample Gene Expression Profiles 1.0 1.03326 Junctional zone TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.449 CRCGN014_HEPG2_3H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.3721 Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.577 posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.07427 Gonadal Disorders CTD Gene-Disease Associations 1.0 1.09822 BRD-K03221986 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24814 leydig cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.592845 brain_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.02717 hsa-miR-3127-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 ISG20L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33181 GSE213588_8_v_1_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null EXOSC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15662 AR-27623747-22RV1-MOUSE-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null abnormal enterocyte proliferation MPO Gene-Phenotype Associations 1.0 null BRD-K51275565 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58391 Obesity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.056 GTEX-WFON-2326-SM-3LK7M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.885639 primary visual cortex (striate cortex, area V1/17)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.871805 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RM-A68T-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE185744,GSE185747_2_v_3_sox9_human RummaGEO Gene Perturbation Signatures -1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-CEBPB_CEBPB Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WHSE-0926-SM-3NMBS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.971333 submucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.53346 BRD-K89767945 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64869 isoniazid-7197 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE216043_3_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Lung adenocarcinoma_LUAD_TCGA-MP-A4TD-01A-32R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE236454,GSE236456_0_v_1_angiotensin ii_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WHWD-0426-SM-3LK83 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.882757 salsolinol-2791 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE231648_4_v_3_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S4Q7-0226-SM-4AD5O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00986 GSE96641_5_v_2_esrp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null pirenzepine-7226 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Mucosa TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 diloxanide-5025 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GR-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.10303 NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.28192 Visceral mass TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.054 corbadrine-7208 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-POYW-0426-SM-2XCEV GTEx Tissue Sample Gene Expression Profiles 1.0 1.0193 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adherens junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.02 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7924-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 3.164 Perturb_13185_Mut_Cry2_SRP303502 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -9.33199 TK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.43209 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ELF4_ELF4 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.0324 GSS CCLE Cell Line Gene Expression Profiles -1.0 -1.4634 POLR2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TSE9-0011-R8A-SM-3DB7R GTEx Tissue Sample Gene Expression Profiles -1.0 -0.839167 GTEX-WH7G-0326-SM-3NMBH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.874146 PMP-22/EMP/MP20/Claudin superfamily InterPro Predicted Protein Domain Annotations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JA-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 6795_PRPF38B_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.707184 BRD-K27638907 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52003 GSE236228_0_v_1_penfluridol_human RummaGEO Drug Perturbation Signatures 1.0 null H3K36me3_megakaryocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Malignant Pleural Mesothelioma DisGeNET Gene-Disease Associations 1.0 null RMG-I Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.23682 GSE68156_3_v_5_dextran_mouse RummaGEO Drug Perturbation Signatures -1.0 null ZNF839 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22495 tooth TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.23604 cell part LOCATE Curated Protein Localization Annotations 1.0 null BRD-K66889220 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36753 testicular cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.238406 GSE179031_3_v_2_foxp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null trimethylcolchicinic acid-2802 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K36me3_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AMO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.04947 PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-4_E2F8-Gene_E2F8 Rummagene Transcription Factor Associations 2026 1.0 null MAZ ENCODE Transcription Factor Targets 1.0 null Frontal lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.059 GTEX-X261-0226-SM-3NMD2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.997482 Midbrain TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.049 GSE95077_5_v_3_amiloride_human RummaGEO Drug Perturbation Signatures 1.0 null integral component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.13961 BRD-K52354895 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16614 tanespimycin-1147 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-U3ZN-1426-SM-3DB87 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.997601 posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.01028 NR1H2::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.16 GTEX-O5YV-1826-SM-2YUNI GTEx Tissue Sample Gene Expression Profiles 1.0 1.12814 Brain Lower Grade Glioma_LGG_TCGA-HT-A74J-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GDM1 CCLE Cell Line Gene Expression Profiles 1.0 2.1702 BRD-K12524104 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.61221 abnormal ileum morphology MPO Gene-Phenotype Associations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A49A-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP in entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.66869 MT-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04125 GTEX-PX3G-1426-SM-48U1J GTEx Tissue Sample Gene Expression Profiles 1.0 0.844441 BRD-K81471597 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07625 BRD-K96627018 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22245 SNU466 CCLE Cell Line Gene CNV Profiles 1.0 1.64946 4149_INTS4_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.67732 Lung adenocarcinoma_LUAD_TCGA-MP-A4T6-01A-32R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null oxytetracycline-1553 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Ovarian Diseases CTD Gene-Disease Associations 1.0 1.13724 MZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.958755 H3K36me3_megakaryocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX ENCODE Transcription Factor Targets 1.0 null BRD-K16626032 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62082 regulation of intestinal lipid absorption GO Biological Process Annotations 2025 1.0 null GTEX-NPJ8-1326-SM-3LK6B GTEx Tissue Sample Gene Expression Profiles 1.0 1.55825 PMC10082806-42003_2023_4756_MOESM4_ESM.xlsx-AML2_RelvsTum_DMRs_anno-annot_symbol_RUNX3 Rummagene Transcription Factor Associations 2026 1.0 null ATP5MG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83505 Pancreas BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.02061 GTEX-QDVN-0526-SM-48TZ4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.13577 BRD-K19523037 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72465 GTEX-U412-0326-SM-3DB9L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0631 CF-50-QK79_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.225916 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5706-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 4696_LSM6_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.573329 H3K36me3_cardiac mesoderm_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Micronuclei, Chromosome-Defective CTD Gene-Disease Associations 1.0 1.44111 NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.40417 GTEX-WFJO-0926-SM-4LVM2 GTEx Tissue Sample Gene Expression Profiles 1.0 2.49628 serous cystadenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.502675 EMC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57485 mediodorsal nucleus of thalamus_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.62021 posteroventral (inferior) parietal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.862721 AD-51-SS86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.971687 HCC2279 CCLE Cell Line Gene CNV Profiles -1.0 -1.85959 outer SZ in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.880171 18451145-TableS1 GeneSigDB Published Gene Signatures 1.0 null PMC10282096-41467_2023_39038_MOESM4_ESM.xlsx-All_genes_Upregulated-ENSG00000177426_TGIF1 Rummagene Transcription Factor Associations 2026 1.0 null PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6795-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Squamous epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.645 GTEX-XQ8I-2126-SM-4BOOM GTEx Tissue Sample Gene Expression Profiles 1.0 1.0376 GTEX-PLZ6-1526-SM-2S1OC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.960609 GSE179031_3_v_1_foxp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XGQ4-1326-SM-4GIDU GTEx Tissue Sample Gene Expression Profiles 1.0 2.40633 HAUS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77891 GSE95771_0_v_1_ruxolitinib_mouse RummaGEO Drug Perturbation Signatures 1.0 null POLR2AphosphoS2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WOFM-1326-SM-3MJFR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.66113 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J4-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HERC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34277 single-organism localization GO Biological Process Annotations 2015 1.0 null PMC7606598-NIHMS1624889-supplement-1624889_Supp_Tab1-10.xlsx-S8_MR-JTI-genename_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null HCC1937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.24755 GTEX-QMRM-1226-SM-447C6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.957974 EE-98-PF86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.416365 SLR25 CCLE Cell Line Gene Expression Profiles 1.0 1.74287 cellular component assembly GO Biological Process Annotations 2015 1.0 null GTEX-OHPK-0326-SM-2HMJO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23562 SC-560-6865 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null skeletalmuscle_e HPA Tissue Sample Gene Expression Profiles -1.0 -1.44879 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4821-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Colonic cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.812 Small_Intestine Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 2.78413 Anemia DisGeNET Gene-Disease Associations 1.0 null OCI-AML3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.923334 subthalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.912791 COV644 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.24388 EB-66-IH06_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.386771 AtrioventricularNode BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.43595 colchicine-644 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null leydig cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.221291 H3K27ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null diethylstilbestrol_mus musculus_gpl6887_gse37969 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Cell-Cell communication Reactome Pathways 2014 1.0 null GSE140200_1_v_0_trim59_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE147662_0_v_4_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null LF-35-CP32_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.364309 BRD-K82785545 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26662 KRI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15389 GTEX-XUJ4-2726-SM-4BOQ1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.03554 trifluoperazine-5221 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null CD71+_EarlyErythroid BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.31354 HT115 CCLE Cell Line Gene Expression Profiles 1.0 2.9526 GSE173232_2_v_3_sf3b1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE158738_0_v_1_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.00862 GTEX-TSE9-0526-SM-3DB7Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05048 nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039717 urinary tract TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-R53T-1826-SM-3GIJX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.75932 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTNNB_Activation (deltaNB-cateninER transgenics)_GDS1560_767_mouse_Skin - 1 Day GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-UJHI-1226-SM-4IHLR GTEx Tissue Sample Gene Expression Profiles 1.0 0.903172 PMC9098426-41540_2022_225_MOESM4_ESM.xls-HCT116_NR1D1_KO-Gene_NR1D1 Rummagene Transcription Factor Associations 2026 1.0 null GSE218580_1_v_0_fentanyl_mouse RummaGEO Drug Perturbation Signatures -1.0 null PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Supplementary_Table_2D_Contrast_ATF4-def_Tg_2h_vs_HCT116Tg_2h_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null SG in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.29847 15-delta prostaglandin J2-201 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Inflammation CTD Gene-Disease Associations 1.0 1.49457 BRD-K76829357 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08446 17616640-TableS1 GeneSigDB Published Gene Signatures 1.0 null Claudin-15 InterPro Predicted Protein Domain Annotations 1.0 null Caco-2/BBe cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.72 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4718-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.1252 GTEX-RWSA-0626-SM-2XCBD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.962183 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A3Y1-01A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cell type benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.046917 abnormal ekg GWASdb SNP-Phenotype Associations 1.0 0.353554 Perturb_6999_KO_Acadl_SRP323582 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 15.4392 GTEX-S341-1826-SM-3K2AB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42089 HS255T CCLE Cell Line Gene Expression Profiles -1.0 -1.72645 interstitial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.193156 BRD-K95822658 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.06848 A549_Resveratrol_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0178118 abnormal cell proliferation MPO Gene-Phenotype Associations 1.0 null JHUEM1 DepMap CRISPR Gene Dependency 1.0 2.16575 H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EP-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24488 HS 766T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.09838 Nervous System Malformations CTD Gene-Disease Associations 1.0 1.07269 Perturb_122_KD_Ywhaz_SRP045772 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 thioridazine-4164 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Prestwick-1082-7267 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-PSDG-0326-SM-48TCP GTEx Tissue Sample Gene Expression Profiles 1.0 1.13607 lm7 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.708 riluzole-7365 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE229973_3_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null tranylcypromine-5996 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K74881104 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13129 Periplasmic flagellum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.507 NCSTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04049 GSE206226_2_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-P78B-2526-SM-3P5ZY GTEx Tissue Sample Gene Expression Profiles 1.0 0.939476 Inflammatory bowel disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.248 GTEX-SNMC-1626-SM-4DM52 GTEx Tissue Sample Gene Expression Profiles 1.0 1.23617 CRCGN017_MCF10A.WT.HP_24H:P09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.08995 abnormality of the cardiovascular system GWASdb SNP-Phenotype Associations 1.0 0.093664 CD-05-PU90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.345208 Erythroid cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.398 abnormal enterocyte morphology MPO Gene-Phenotype Associations 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11D-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ECEL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28687 SG in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.865369 JIMT-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.841325 S0-EE-X7LX_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.222181 GTEX-X3Y1-0926-SM-3P5YT GTEx Tissue Sample Gene Expression Profiles 1.0 1.94414 GSE193402_0_v_1_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.869765 HS 69ST Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.79481 Testicular cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.362 outer SZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.01054 OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18995 Small_Intestine-intestinal crypt stem cell Tabula Sapiens Gene-Cell Associations 1.0 1.50063 3-hydroxy-DL-kynurenine-2654 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HC-01-FD24_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.569577 MTRES1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06417 meclozine-4646 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4771-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K36me3_megakaryocyte_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUJ4-0126-SM-4BOP7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20415 GTEX-Q734-1126-SM-48TZY GTEx Tissue Sample Gene Expression Profiles 1.0 1.5606 PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Unnamed_2_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null tight junction GO Cellular Component Annotations 2025 1.0 null BRD-K44492160 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09559 GTEX-XAJ8-1126-SM-47JYA GTEx Tissue Sample Gene Expression Profiles 1.0 1.22072 Rootlet TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.779 HCFC1 ENCODE Transcription Factor Targets 1.0 null BNC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.0406 OVCAR-4 GDSC Cell Line Gene Expression Profiles 1.0 1.62736 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null cortisone-2385 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-QXCU-1926-SM-48FE4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05258 zuclopenthixol-4261 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN015_MCF10A_48H:F02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.7404 BRD-K91297952 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16293 BRD-K02811477 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19357 methyldopa-5272 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null transport GO Biological Process Annotations 2015 1.0 null 2204_DHX16_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.519189 PPARG-20887899-3T3-L1 PREADIPOCYTE CELLS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPN-0011-R3A-SM-2I5FC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.962694 COV644 CCLE Cell Line Gene Expression Profiles 1.0 2.73745 BRD-K89863047 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18723 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5UM-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.991527 Mucous gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.946 HCC2218 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.838395 HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.75131 ZBTB7A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null occluding junction COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 occluding junction LOCATE Curated Protein Localization Annotations 1.0 null NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.09398 apical junction complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 TALH cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.567 GSE77108_0_v_1_saha_human RummaGEO Drug Perturbation Signatures -1.0 null Gastric gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.995 Acute Myeloid Leukemia_LAML_TCGA-AB-2937-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Collecting duct TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.245 H3K36me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null tight junction COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 nb4 HPA Cell Line Gene Expression Profiles 1.0 1.32296 hsa-miR-486-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 Thymus-medullary thymic epithelial cell Tabula Sapiens Gene-Cell Associations 1.0 2.37382 RAD21 ChEA Transcription Factor Targets 1.0 null H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE232558_0_v_2_fbxl12_human RummaGEO Gene Perturbation Signatures -1.0 null Cell junction organization Reactome Pathways 2014 1.0 null U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.931594 Overnutrition DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.055 Lung adenocarcinoma_LUAD_TCGA-55-A494-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Apical plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.953 8230_SNRPD3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.547247 tonzonium bromide-5678 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null chaperonin-containing T-complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.007 BRD-K60635455 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20785 SNU840 CCLE Cell Line Gene Expression Profiles -1.0 -1.9938 BRD-K35404627 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80294 Vascular endothelial cell_Kidney_Mouse CellMarker Gene-Cell Type Associations 1.0 null GSE137954_4_v_2_smyd3_mouse RummaGEO Gene Perturbation Signatures -1.0 null lynestrenol-5355 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE60217_1_v_8_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null T3M5 DepMap CRISPR Gene Dependency 1.0 2.1377 Pancreas GTEx Tissue Gene Expression Profiles 2023 1.0 2.73968 SARS-BatSRBD_60Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.08355 PA-TU-8902 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.832699 primary auditory cortex (core)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.4439 metronidazole-4023 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Caco-2/15 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.525 MZ in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.52275 cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.91227 schwann cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.175984 BRD-K04544693 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01875 Limbic system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_7Hour_None_GSE43203 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.19505 GTEX-N7MS-0011-R3a-SM-33HC6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27103 Perturb_6944_KO_Xirp2_SRP259323 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 10.927 CENPM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29808 TP63 ChEA Transcription Factor Targets 1.0 null PALB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62687 Outer mucus layer COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.873 BB-87-SF89_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.206542 MTA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32907 DPH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94262 GTEX-TSE9-0011-R1A-SM-3DB7E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.87171 GSE169356_0_v_4_ivermectin_human RummaGEO Drug Perturbation Signatures 1.0 null sulpiride-1467 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE152432_5_v_2_zrsr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XV7Q-0005-SM-4BRWI GTEx Tissue Sample Gene Expression Profiles 1.0 1.27983 496100577_FWM_probable Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.82852 GTEX-QEG4-0626-SM-2S1OY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.75329 NCIH322 CCLE Cell Line Gene Expression Profiles -1.0 -1.57314 496100497_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.79989 GTEX-VUSG-2726-SM-4KKZJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.989215 hippocampus (hippocampal formation)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.933092 8228_SNRPD1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.736256 layer VI of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.32627 JEKO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09157 GSE180200,GSE180201_5_v_0_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K88179544 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55569 MZ in dorsomedial parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.16429 Lung squamous cell carcinoma_LUSC_TCGA-90-A4ED-01A-31R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB7A ENCODE Transcription Factor Targets 1.0 null Disease of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 Acute Myeloid Leukemia_LAML_TCGA-AB-2920-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU520 CCLE Cell Line Gene Expression Profiles 1.0 2.37477 GTEX-Q2AG-0011-R3A-SM-2HMJ9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.861649 BRD-K79604175 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34499 GSE102870_1_v_2_nr1h4_human RummaGEO Gene Perturbation Signatures -1.0 null PMC10896338-media-3.xlsx-GSEQ_TF_AP1_UP_DOWN-Unnamed_1_JUN Rummagene Transcription Factor Associations 2026 1.0 null disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.029503 GTEX-NPJ8-1626-SM-2HMIY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.882228 ZBTB12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.4418 PA-TU-8988T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.36929 apical part of cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.499042 Musculoskeletal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.176 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5458-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K23666684 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.8493 theobromine-4958 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null JAR COSMIC Cell Line Gene Mutation Profiles 1.0 null stratum pyramidale of rostral CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00951 H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE229973_3_v_6_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null NCI-H209 GDSC Cell Line Gene Expression Profiles -1.0 -1.53337 GSE180200,GSE180201_2_v_9_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null furosemide-3197 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Cervix - Ectocervix GTEx Tissue Gene Expression Profiles 2023 1.0 5.69786 Chloride channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.284 posteroventral (inferior) parietal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.13529 Malignant Mesothelioma Of Peritoneum DisGeNET Gene-Disease Associations 1.0 null cefalonium-7341 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null VI, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.00375 BRD-K77609086 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35087 ZNF549 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47057 PLC/PRF/5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.44552 BRD-K30812092 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.31938 Apicolateral plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.506 GSE155830_1_v_0_fkbp5_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE213588_10_v_5_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70N-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE157233_2_v_4_a1cf_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF701 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 79.2142 endocrine/exocrine gland phenotype MPO Gene-Phenotype Associations 1.0 null Autoimmune disease of gastrointestinal tract DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.041 GSE95077_5_v_0_amiloride_human RummaGEO Drug Perturbation Signatures 1.0 null HTR3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23443 spanning component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.246407 doxorubicin_homo sapiens_gpl550_gds846 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cellular_component GO Cellular Component Annotations 2015 1.0 null GTEX-XOT4-0526-SM-4B66O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53498 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AP-01A-12R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cell-cell junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.35978 Brush border COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.877 GSE211128_4_v_0_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null HSD11B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51083 Immune system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.673 BRD-K02979518 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17928 CBX3 ENCODE Transcription Factor Targets 1.0 null GSE216043_10_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null 8184_SMN2_ENST00000380743.4 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.530779 KYSE-410 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K16331797 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56774 GSE48812_8_v_1_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null Brush cell (Tuft cell)_Intestinal crypt_Mouse CellMarker Gene-Cell Type Associations 1.0 null GB-57-XV52_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.231052 kidney TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.35334 myclobutanil LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01561 GSE216273,GSE216292_14_v_7_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null mRNA_MSC_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null GSE207122_1_v_0_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null azacyclonol-2020 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SUM 52PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.824037 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AQ-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ichthyosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.55 novobiocin-499 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE203308_6_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-X585-0005-SM-46MV3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.975213 CRCGN015_HEPG2_48H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.51957 nitrofurantoin-2303 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.381 dirithromycin-1712 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null clozapine-1654 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE120595_0_v_4_arid2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Runx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.663 primary auditory cortex (core)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.4291 kidney TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K19387722 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7402 POLR2AphosphoS2_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null benperidol-2836 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Enterocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.113 GTEX-X4XY-0626-SM-4E3IN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24995 GTEX-OIZI-0526-SM-2XCEG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.979845 H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WZTO-0011-R3B-SM-3NMC6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.829733 outer SZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00822 H3K36me3_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KYSE-270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.903803 isometheptene-5082 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null tolazamide-4003 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Renal hypomagnesemia 5 with ocular involvement DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.13 CA3 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.943446 RMUG-S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.29435 OV56 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.956899 ZMAT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22578 GSE234637_1_v_0_ikzf1_human RummaGEO Gene Perturbation Signatures -1.0 null paracellular transport GO Biological Process Annotations 2025 1.0 null basal ventral medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01728 GTEX-QEL4-0426-SM-3GACZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.26229 thiamphenicol-7033 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CREB1 JASPAR Predicted Transcription Factor Targets 1.0 null cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Wnt2+ cell_Lung_Mouse CellMarker Gene-Cell Type Associations 1.0 null GTEX-QXCU-1726-SM-2TC6L GTEx Tissue Sample Gene Expression Profiles -1.0 -2.27428 DL-thiorphan-6249 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HT-1376 GDSC Cell Line Gene Expression Profiles -1.0 -1.54212 tolnaftate-2001 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null malignant pleural mesothelioma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.547419 H3K27ac_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K36763492 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.445 CRCGN017_MCF10A.WT.HP_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.43425 gonad TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.172855 CA2 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.92052 NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.902923 posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.00298 Learning Disorders CTD Gene-Disease Associations 1.0 1.0894 salivarygland_6b HPA Tissue Sample Gene Expression Profiles -1.0 -1.01078 GTEX-XUZC-2126-SM-4BRW8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20149 cell-cell adhesion via plasma-membrane adhesion molecules GO Biological Process Annotations 2025 1.0 null Cell junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.675 Infertility, Male CTD Gene-Disease Associations 1.0 1.23042 IM-95M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.27759 BRD-K18488784 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.0508 GTEX-SIU8-0526-SM-2XCDP GTEx Tissue Sample Gene Expression Profiles -1.0 -2.35016 BRD-K25039453 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24094 GTEX-U3ZN-1026-SM-4DXTC GTEx Tissue Sample Gene Expression Profiles 1.0 1.16664 spiramycin-3844 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-UJMC-1326-SM-4IHLS GTEx Tissue Sample Gene Expression Profiles 1.0 1.3249 PMC12198892-pi-2025-0101-Supplementary-Material.pdf-46-PREB_PREB Rummagene Transcription Factor Associations 2026 1.0 null BRD-K18865369 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58768 Short bowel syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.704 GTEX-XBED-1426-SM-4AT4G GTEx Tissue Sample Gene Expression Profiles 1.0 3.37096 primary auditory cortex (core)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.15584 Sox7 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.1316 tyloxapol-4611 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 8505C CCLE Cell Line Gene Expression Profiles -1.0 -1.77742 rilmenidine-5107 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null musculoskeletal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.053912 dipivefrine-7124 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XMD1-0826-SM-4AT52 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09439 496100554_FWM_no dementia_no TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.6119 GTEX-WL46-0626-SM-3LK7R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14716 QT interval GWAS Catalog SNP-Phenotype Associations 1.0 0.165905 NCI-H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.945096 gliquidone-6004 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K06486611 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04833 cyclopentolate-5734 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCI H322M BioGPS Cell Line Gene Expression Profiles -1.0 -2.8634 TFAP2A JASPAR Predicted Transcription Factor Targets 1.0 null Perturb_10150_KO_FOXK2_SRP251223 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GSE158834_10_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null CW-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K56916066 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69139 GSE216273,GSE216292_0_v_8_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null bj HPA Cell Line Gene Expression Profiles -1.0 -1.09691 GSE104508_0_v_1_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null UACC-257 COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_123_KD_Fto_SRP314220 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.87455 S0-EE-YEKU_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.33381 GSE96641_3_v_0_esrp2_mouse RummaGEO Gene Perturbation Signatures -1.0 null fulvestrant-523 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null trichostatin A-3566 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null USF1 ENCODE Transcription Factor Targets 1.0 null GTEX-PW2O-0126-SM-48TC8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.943504 Sarcoma_SARC_TCGA-WP-A9GB-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null bicellular tight junction assembly GO Biological Process Annotations 2023 1.0 null BRD-K70093308 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09925 NUGC-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.73409 BRD-K83726109 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12869 GSE152432_6_v_2_zrsr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null reticular nucleus of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.02698 7834_SF3A3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.12931 PMC11221067-JCMM-28-e18520-s002.xlsx-Supplementary_Table_2-NFKB1_NFKB1 Rummagene Transcription Factor Associations 2026 1.0 null inflammatory bowel disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.272241 OVCA420 DepMap CRISPR Gene Dependency 1.0 4.97348 USF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5360-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WYVS-2326-SM-3NMAI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70491 GSE258991_1_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null Hepatitis C KEGG Pathways 2026 1.0 null NCIH1339 CCLE Cell Line Gene CNV Profiles -1.0 -1.39926 ZNF263 ENCODE Transcription Factor Targets 1.0 null heptaminol-7313 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null orbital frontal cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.857259 GTEX-XV7Q-1426-SM-4BRWA GTEx Tissue Sample Gene Expression Profiles 1.0 1.09731 Small_Intestine-mature enterocyte Tabula Sapiens Gene-Cell Associations 1.0 1.51347 khellin-1504 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 6552_POLR2K_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.57192 hippocampus (hippocampal formation)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 3.411 BRD-K16496880 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12243 Auditory vesicle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.884 anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.17133 Hemidesmosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.891 Ileitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.168 SK-MES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.81188 GTEX-VUSG-1726-SM-4KKZL GTEx Tissue Sample Gene Expression Profiles 1.0 2.09162 GSE242290_3_v_0_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4352-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pheniramine-1492 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Congenital diarrhea DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.352 METTL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.84647 GTEX-TKQ2-1326-SM-4DXT9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.14114 GSE235550_1_v_0_hspa9_human RummaGEO Gene Perturbation Signatures 1.0 null Cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.029 NB6 COSMIC Cell Line Gene Mutation Profiles 1.0 null SDHAF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7005 BRD-K76508844 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.60845 Developmental disorder of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 GTEX-P4QS-1326-SM-3NMCD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13681 KASUMI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.24603 H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cochlear nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08001 KLM1 CCLE Cell Line Gene Expression Profiles -1.0 -2.76769 bendroflumethiazide-3758 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-SSA3-0226-SM-32QPN GTEx Tissue Sample Gene Expression Profiles 1.0 1.0526 CRCGN016_MCF10A.TP53.M_24H:C10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.23523 fendiline-1573 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K36me3_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZH-1626-SM-2HMKI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32599 POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Fibrochondrogenesis 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.002 GTEX-U8T8-1426-SM-3DB9H GTEx Tissue Sample Gene Expression Profiles -1.0 -0.990671 rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.885836 diclofenac-2756 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null amygdaloid complex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.18309 H3K36me3_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFG::NFE2L1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.3072 BRD-K02060635 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45793 BRD-K75410936 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28276 BRD-K36204977 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.99567 H3K27me3_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null establishment of localization GO Biological Process Annotations 2015 1.0 null BRD-K18958510 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.96726 HCC1419 CCLE Cell Line Gene Expression Profiles -1.0 -1.55949 NCI-H1930 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.97441 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-US-A77E-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OXRK-0426-SM-3NB2E GTEx Tissue Sample Gene Expression Profiles 1.0 1.22181 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.032249 SW 837 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.835924 Bronchial epithelial cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.039 GSE120415,GSE120447_0_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null duodenum_4c HPA Tissue Sample Gene Expression Profiles 1.0 1.85066 SET2 CCLE Cell Line Gene CNV Profiles -1.0 -1.53365 PMC5291205-srep41905-s3.xlsx-LPS_datasets_gmx-Unnamed_2_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null III, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.908527 GTEX-O5YW-0326-SM-2I5EI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34415 connective tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063166 kidney HPA Tissue Protein Expression Profiles -1.0 -0.726527 BRD-K93457574 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20667 Brain Lower Grade Glioma_LGG_TCGA-TM-A84H-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mRNA_TCEA3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null SNU-C1 GDSC Cell Line Gene Expression Profiles 1.0 2.3122 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QH-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ATF3_02_54 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59064 GTEX-NPJ7-1726-SM-2YUNA GTEx Tissue Sample Gene Expression Profiles 1.0 1.4254 octopamine-3112 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08701 GSE216043_7_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Apical part of cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.311 H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H82 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00137 SNU626 DepMap CRISPR Gene Dependency 1.0 3.17863 laterorostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.876481 MDCK cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.938 SARS-BatSRBD_36Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.08207 H3K36me3_Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null C32 CCLE Cell Line Gene CNV Profiles 1.0 1.97815 hnf4a_16714383_e18dot5_liver_lof_mouse_gpl1261_gds1916 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.250941 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-06A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K39499927 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00205 GTF3C3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38136 BRD-K84939696 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72409 Acute Myeloid Leukemia_LAML_TCGA-AB-2841-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ZC3H11C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03654 GTEX-QMR6-0011-R6A-SM-32PKP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.907759 Lung adenocarcinoma_LUAD_TCGA-L4-A4E5-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Unnamed_1_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null HCC1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.92587 Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.649 7463_RPL35_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.592693 H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OOBJ-1626-SM-2I3F7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.80701 Pleural cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.681 miconazole-6615 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE246195,GSE246305_4_v_5_sin3a_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QEG4-1126-SM-2S1P7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.83737 HNF4G ENCODE Transcription Factor Targets 1.0 null PPARG-20887899-3T3-L1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE213588_8_v_4_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null TA-34-CK62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.613392 GSE202434,GSE202438_7_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null ileum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.302118 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.630314 BC-1 GDSC Cell Line Gene Expression Profiles 1.0 1.64914 JK1 CCLE Cell Line Gene Expression Profiles 1.0 1.44305 Lung squamous cell carcinoma_LUSC_TCGA-85-A4PA-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100592_FWM_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.31871 metabolic acidosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.357446 CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletalmuscle_b HPA Tissue Sample Gene Expression Profiles -1.0 -1.58702 hydrocortisone-3284 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney Chromophobe_KICH_TCGA-KN-8423-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D6-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D9-A4Z5-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null salivary gland HPA Tissue Gene Expression Profiles -1.0 -0.853883 disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.296211 ciprofibrate-5740 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null bromocriptine-5665 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XPT6-2026-SM-4B64V GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17671 Lung squamous cell carcinoma_LUSC_TCGA-43-6143-11A-01R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GINS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39617 tetryzoline-6069 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE211286_7_v_3_tcf12_mouse RummaGEO Gene Perturbation Signatures -1.0 null Corpora quadrigemina TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.619 Colonic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.547 MFM-223 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.832699 GSE203308_6_v_3_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K84478344 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04493 Primary immunodeficiency disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.72 GTEX-PX3G-0008-SM-48U2L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.831374 GTEX-WK11-2526-SM-3NM9Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.89616 MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03697 ethaverine-6737 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null abnormal intestinal mucosa morphology MPO Gene-Phenotype Associations 1.0 null Primary hematopoietic stem cells G-CSF-mobilized Female RO_01536 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.27166 JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE169571_0_v_2_dexamethasone_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE199204,GSE211619_4_v_1_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H2052 GDSC Cell Line Gene Expression Profiles -1.0 -2.93202 glycopyrronium bromide-7386 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null phenindione-2868 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE154081_1_v_0_sildenafil_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XAJ8-0926-SM-47JXZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.38893 MAF::NFE2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.9661 SEC31B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.19901 dinoprost-6308 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Prefrontal cortex TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.002 GTEX-XYKS-1326-SM-4BRUN GTEx Tissue Sample Gene Expression Profiles 1.0 0.969436 BRD-K38403252 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.88977 meclofenamic acid-7280 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XPT6-0126-SM-4B65S GTEx Tissue Sample Gene Expression Profiles -1.0 -0.997806 GSE152432_6_v_4_zrsr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-X8HC-0526-SM-4E3JA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.932614 dl-alpha tocopherol-6616 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-RUSQ-1826-SM-2TF6E GTEx Tissue Sample Gene Expression Profiles 1.0 1.19033 Peritoneum cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.263 GSE217552_3_v_4_fisetin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE150669_2_v_3_roxadustat_mouse RummaGEO Drug Perturbation Signatures -1.0 null fluorouracil_homo sapiens_gpl550_gds846 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K36me3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XXEK-0326-SM-4BRVV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.925725 abnormal duodenum morphology MPO Gene-Phenotype Associations 1.0 null pivmecillinam-7312 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 5140203-908 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SNU-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.872158 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1 Rummagene Transcription Factor Associations 2026 1.0 null DB GDSC Cell Line Gene Expression Profiles 1.0 1.68041 HNF4A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Paneth cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.71 alprenolol-1571 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.919177 IC-28-HS37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.22235 SNU-216 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.214 clioquinol-3084 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC11994596-DataSheet1.pdf-46-ELF3_ELF3 Rummagene Transcription Factor Associations 2026 1.0 null etodolac-2091 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Fatty Liver CTD Gene-Disease Associations 1.0 1.60734 SREBF2 JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-SNOS-1226-SM-4DM5H GTEx Tissue Sample Gene Expression Profiles 1.0 0.868715 Hippocampus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4822-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AGO1_02_162 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.62563 GTEX-SE5C-2126-SM-4BRUJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.46875 GTEX-WRHU-0826-SM-3MJFN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62306 GSE193993_5_v_6_sstr2_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-QDVJ-0426-SM-2I5FW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.859798 CRCGN011_HEPG2_24H:J18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.7429 GTEX-U3ZH-0926-SM-4DXU4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.966876 GSE146687_2_v_5_eribulin_human RummaGEO Drug Perturbation Signatures 1.0 null FB-32-TL51_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.242334 Prostate adenocarcinoma_PRAD_TCGA-EJ-A46G-01A-31R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K94962273 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30334 GTEX-UPK5-0326-SM-3GAF3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.951949 GSE165682_0_v_3_ptbp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XGQ4-0326-SM-4GIEE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37261 intestinal mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.11278 SKOV3 CCLE Cell Line Gene CNV Profiles -1.0 -1.50364 GTEX-QCQG-2126-SM-2S1P8 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.23263 clofazimine-5277 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RS11846 BioGPS Cell Line Gene Expression Profiles 1.0 1.67882 pioglitazone-7523 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Prostate adenocarcinoma_PRAD_TCGA-J4-A67M-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null phthalylsulfathiazole-4653 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Thoracic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.241 prazosin-5416 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CEBPD ENCODE Transcription Factor Targets 1.0 null CA46 GDSC Cell Line Gene Expression Profiles 1.0 1.89989 HNF4A-19761587-HUMAN INTESTINAL CELL LINE CACO-2-human ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K14756138 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06425 SF539 GDSC Cell Line Gene Expression Profiles -1.0 -2.54929 LY-294002-501 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TACO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06321 KDM5B ENCODE Transcription Factor Targets 1.0 null BRD-K29794647 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43688 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HF-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DPPA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04735 9473_U2AF1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.540031 Colonocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.745 Lung adenocarcinoma_LUAD_TCGA-O1-A52J-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE102132_2_v_1_irf3_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null single-organism cellular process GO Biological Process Annotations 2015 1.0 null H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K21466747 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.43586 SPEG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00351 moroxydine-5304 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.64778 BRD-K16933266 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14053 PMC12867126-NIHMS2139346-supplement-Supplementary_Table_S1.pdf-21-EMX2_EMX2 Rummagene Transcription Factor Associations 2026 1.0 null outer CP in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.901649 BRD-K63420290 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36264 H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CHL-1 GDSC Cell Line Gene Expression Profiles 1.0 1.77502 Charcot-Marie-Tooth disease type 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.081 CRCGN017_MCF10A.WT.HP_24H:J12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0169 ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null Perturb_15889_KO_Dnajb6_SRP357786 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.68419 IA-76-ZU47_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.381491 GTEX-S4Z8-1826-SM-3K2BH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.944018 Polymeric IgA immunoglobulin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.801 PKBalpha_KO_GDS1784_193_mouse_Embryonic fibroblasts (MEFs) - 0 hour GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-Q2AI-1426-SM-2S1P5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.948109 BRD-K40923781 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33891 7830_SF3A1_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.844677 BRD-K10011427 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20484 WHSC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null KG1 CCLE Cell Line Gene CNV Profiles -1.0 -2.18755 pancreas HPA Tissue Gene Expression Profiles -1.0 -1.06497 GTEX-OHPN-0011-R7A-SM-2I5FI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.865469 BRD-K18621941 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21639 BRD-K44797874 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32606 BRD-K90697693 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14405 primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.843202 GSE216273,GSE216292_14_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-POMQ-1926-SM-3NB1Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46101 BRD-K80239721 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2913 CRCGN008_HEPG2_24H:D01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.211 NCI-H226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.06532 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5468-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K65315551 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01144 GTEX-P4QT-1626-SM-2S1NP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16497 anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.89843 monorden-493 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null posteroventral (inferior) parietal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.62259 GTEX-PX3G-0326-SM-2I3EO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12508 GTEX-QV44-2026-SM-2S1RD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3751 BRD-K43468685 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04661 loracarbef-5073 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K73442516 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.95687 COLO 699 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.71717 GSE132948,GSE132949_0_v_1_msi2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XV7Q-1726-SM-4BRUU GTEx Tissue Sample Gene Expression Profiles 1.0 1.27122 Inflammatory breast carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.054 RABGEF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.90801 MDAMB453 CCLE Cell Line Gene CNV Profiles -1.0 -2.15918 primary auditory cortex (core)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.47979 Tcf12 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.4607 CSAD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86409 SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01453 CRCGN009_HEPG2_24H:E13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0423 Brain Lower Grade Glioma_LGG_TCGA-DH-A7UV-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null vitexin-2810 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Diarrhea DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.947 GTEX-XMD1-0526-SM-4AT4Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.1118 SU-DHL-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.969529 THAP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.882 PMC10756545-pone.0296454.s002.xlsx-8_Normal_premalignant_modules-N10_NR4A1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S4Q7-0826-SM-4AD5E GTEx Tissue Sample Gene Expression Profiles 1.0 1.20705 todralazine-5087 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Cell-cell junction organization Reactome Pathways 2024 1.0 null POLG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62919 etidronic acid-3325 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null pleural cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.544705 cell-cell adhesion via plasma-membrane adhesion molecules GO Biological Process Annotations 2023 1.0 null thioperamide-4675 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney Diseases CTD Gene-Disease Associations 1.0 1.33731 naftidrofuryl-6687 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE111035,GSE111040_8_v_12_plag1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Glucose intolerance DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.291 molsidomine-5426 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-OOBJ-0326-SM-33HBO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25566 abnormal jejunum morphology MGI Mouse Phenotype Associations 2023 1.0 null GSE237040_0_v_3_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Acute Kidney Injury CTD Gene-Disease Associations 1.0 1.15022 GSE144115_1_v_3_stag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE132948,GSE132949_2_v_3_msi2_mouse RummaGEO Gene Perturbation Signatures 1.0 null KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.86757 tetraethylenepentamine-574 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K36me3_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 15208663-Table2 GeneSigDB Published Gene Signatures 1.0 null HS 683 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.3048 GTEX-WL46-2026-SM-3LK7U GTEx Tissue Sample Gene Expression Profiles 1.0 0.857347 GSE135514_8_v_3_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE97278,GSE97280_2_v_3_nsd2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Edinger-Westphal nucleus (accessory oculomotor nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05844 AB-33-EM56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.227775 H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A623-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMIM26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75032 primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.923967 BRD-K90325960 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42409 Hypothalamus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.225 GTEX-XXEK-0126-SM-4BRVU GTEx Tissue Sample Gene Expression Profiles 1.0 1.32203 PPARG-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null DD-74-PJ26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.224585 H3K9ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null stratum lacunosum-moleculare of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.28454 Adrenocortical carcinoma_ACC_TCGA-P6-A5OF-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-UPK5-2326-SM-3P5Z8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.87589 G402 DepMap CRISPR Gene Dependency 1.0 5.63799 GTEX-WFON-0326-SM-3GIKX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40977 UKE-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.99861 PLK3_knockdown_121_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.01324 troxerutin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05792 VIIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.943428 pirinixic acid-481 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IL-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K08458391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03586 RERFLCSQ1 CCLE Cell Line Gene CNV Profiles 1.0 1.38864 non-small cell lung carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.084237 GSE132948,GSE132949_4_v_1_msi2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WFG7-1726-SM-4LVME GTEx Tissue Sample Gene Expression Profiles 1.0 2.25783 hek293 HPA Cell Line Gene Expression Profiles 1.0 0.862496 Uterine Carcinosarcoma_UCS_TCGA-N5-A59F-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J3-01A-12R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tight junction GO Cellular Component Annotations 2023 1.0 null FE-64-KC49_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.354036 Integumentary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.12 LM-1685-207 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null oocyte BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.07371 MYF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.1775 HCC1576 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.90213 abnormal intestinal goblet cell morphology MPO Gene-Phenotype Associations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7080-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE48812_11_v_1_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null Colonic epithelium cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.024 GTEX-NFK9-0626-SM-2HMIV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30912 RH28 DepMap CRISPR Gene Dependency 1.0 2.89833 GSE122425_1_v_0_nsun2_human RummaGEO Gene Perturbation Signatures 1.0 null CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mRNA_TCF3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Right colon TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.188 BRD-K09395335 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51007 lysergol-6621 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE162688_1_v_4_pink1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Colorectal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.8 Epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.162 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4811-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAL1-20566737-PRIMARY-FETAL-LIVER-ERYTHROID-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC5195898-NIHMS825571-supplement-3.xlsx-Sheet1-H1975_M1_vs_H1975_M1_CIC_reconstitution_Differential_gene_expression_CIC Rummagene Transcription Factor Associations 2026 1.0 null 17430594-tableS3 GeneSigDB Published Gene Signatures 1.0 null ventrolateral prefrontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.16831 BRD-K91648652 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.07093 NSD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0086 GSE210655_3_v_7_cisplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRL-1626-SM-2YUMU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54306 CPSF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39563 MDA-MB-134-VI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.879211 7607_RUVBL1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.708937 Lung cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.084 VZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.51222 GSE149124,GSE149128_3_v_0_cdk7_mouse RummaGEO Gene Perturbation Signatures 1.0 null TXNDC17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24396 cefoperazone-1627 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE154577_7_v_10_plagl1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE112860_5_v_7_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE48812_3_v_1_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WVLH-0011-R10A-SM-3MJFM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.829044 IGLON5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44853 nordihydroguaiaretic acid-524 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Submucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.666 FF-28-ES17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.445331 Perturb_7769_KD_Y14_DRP003223 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 8.72235 GTEX-XPVG-2826-SM-4B66J GTEx Tissue Sample Gene Expression Profiles 1.0 1.11304 GTEX-RM2N-1626-SM-2TF5N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45084 AK6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90195 GTEX-U8XE-0726-SM-3DB8O GTEx Tissue Sample Gene Expression Profiles -1.0 -2.71497 UF-27-HS98_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.211801 diphenhydramine-6020 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Viscus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 glibenclamide-1546 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7388-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7SF-2226-SM-3K2BG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.903467 GSE110178_2_v_3_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures -1.0 null LY-294002-6995 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-OXRK-1826-SM-2HMJE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29821 enilconazole-5113 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.635976 metrifonate-1675 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null zidovudine-1595 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A4-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null diclofenac-5861 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-TMMY-0426-SM-33HBB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24287 H3K27ac_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K16955082 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0686 GTEX-WH7G-1326-SM-4LVMS GTEx Tissue Sample Gene Expression Profiles 1.0 1.12613 sotalol-7338 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RXRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.1817 ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.314683 HEL DepMap CRISPR Gene Dependency 1.0 4.97048 GTEX-P44H-0426-SM-2XCEZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.92643 DD-65-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.38195 idoxuridine-1980 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN008_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5074 Perturb_144_KD_Tmbim1_SRP319088 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 GTEX-X3Y1-2426-SM-3P5Z7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.40518 SK-OV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.26824 H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE167004_0_v_3_thpo_mouse RummaGEO Gene Perturbation Signatures -1.0 null Neoplasms, Experimental CTD Gene-Disease Associations 1.0 1.22112 CRCGN015_HEPG2_48H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.03297 eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A2780 GDSC Cell Line Gene Expression Profiles -1.0 -1.8092 BRD-K62650632 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04415 BRD-K90901488 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56918 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A69B-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC3023804-pone.0016344.s008.xls-S3_High_Confidence_PPAR_Peaks-Primary_Gene_Name_PPARA Rummagene Transcription Factor Associations 2026 1.0 null Cornified envelope formation KEGG Pathways 2026 1.0 null GSE151090_0_v_4_verteporfin_human RummaGEO Drug Perturbation Signatures 1.0 null 496100494_HIP_no dementia_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.62795 GTEX-WFG7-1526-SM-4LVMG GTEx Tissue Sample Gene Expression Profiles 1.0 0.973282 Tight junction interactions Reactome Pathways 2024 1.0 null GTEX-XBED-2626-SM-4E3J5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.73855 BRD-K42943023 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09732 mediodorsal nucleus of thalamus_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.01626 sulfanilamide-3449 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Sarcomatoid mesothelioma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.782 PMC8175556-42003_2021_2140_MOESM6_ESM.txt--NFKB1_NFKB1 Rummagene Transcription Factor Associations 2026 1.0 null duodenum_4b HPA Tissue Sample Gene Expression Profiles 1.0 1.80495 H3K4me1_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SCC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.923334 JL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17861 GABP-19822575-HEPG2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null FAM110A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01582 PKBalpha_KO_GDS1784_195_mouse_Embryonic fibroblasts (MEFs) - 6h GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Rectum adenocarcinoma_READ_TCGA-AG-3732-01A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OCI-M1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.00705 BRD-K53720386 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46258 MB-46-BT89_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.450884 JE-55-OJ53_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.245233 resveratrol-5084 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC7481169-277_2020_4194_MOESM7_ESM.xlsx-RUNX1_R139G-Unnamed_1_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null TRIM16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2162 PPARG ChEA Transcription Factor Targets 1.0 null CKAP2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28762 H3K36me3_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E8-11A-12R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE68156_0_v_5_dextran_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE232631_5_v_1_brca2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K59542165 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3228 MDAMB436 CCLE Cell Line Gene CNV Profiles 1.0 1.46906 peritoneal mesothelioma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.04882 Hyperplasia CTD Gene-Disease Associations 1.0 1.63899 HNF4G_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mebhydrolin-4211 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Exocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.861 GSE48812_8_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null metanephrine-1515 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K87418410 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43456 membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042953 FA-63-WI26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.715963 ERA-21632823-H3396-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Small_Intestine-immature enterocyte Tabula Sapiens Gene-Cell Associations 1.0 11.0801 IFT80 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53331 gingiva TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.484766 GSE110178_4_v_7_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures -1.0 null R-atenolol-4841 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PFSK1 DepMap CRISPR Gene Dependency 1.0 4.0102 GOT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12699 GSE122067_3_v_1_mtch2_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-296-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 Perturb_1427_OE_Mir335_ERP106848 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.71666 POLR3K CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29345 CA-75-HA22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.435018 primary auditory cortex (core)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.67225 diperodon-1575 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.08685 tylosin-tartrate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.07758 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.671 Gap junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.558 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5UL-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.36969 H3K36me3_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ARNT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.11138 medial geniculate complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.966495 SOX9-25088423-EMBRYONIC GONADS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-S95S-1426-SM-2XCDM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27242 H3K36me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Intestinal benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.109 BRD-K15358569 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44839 GSE239578_0_v_3_cxadr_mouse RummaGEO Gene Perturbation Signatures 1.0 null jejunum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.630314 MDCK-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.106 Ptf1a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 53.8659 small intestine HPA Tissue Gene Expression Profiles 1.0 1.30663 Secretory IgA immunoglobulin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.836 GTEX-W5WG-1126-SM-4LMK4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.893853 central gray of the pons, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.930266 Lung squamous cell carcinoma_LUSC_TCGA-63-A5MW-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DOK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.906571 posteroventral (inferior) parietal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.904476 H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Piperonyl Butoxide CTD Gene-Chemical Interactions 1.0 null POLR2AphosphoS5_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNF4A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null norethisterone-7414 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null LF-35-CP32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.212361 BRD-K38904629 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0447 PPP2R3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.68084 OE33 COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 Prostate adenocarcinoma_PRAD_TCGA-XQ-A8TA-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STAC3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00467423 cardiovascular system disease GWASdb SNP-Disease Associations 1.0 0.074276 Prestwick-860-5679 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE228727_2_v_0_dapagliflozin_mouse RummaGEO Drug Perturbation Signatures 1.0 null 8621_SYMPK_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.534745 MM253 DepMap CRISPR Gene Dependency 1.0 2.10042 HS 940.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.928979 primary auditory cortex (core)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01571 SYK_druginhibition_285_GSE43510 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.11409 GTEX-P4PP-0326-SM-33HC4 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.03507 MDCK-2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.796 6-benzylaminopurine-2351 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null EGR-1_KO_GDS3607_525_mouse_Retina - 30 Days (POST-NATAL) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-WY7C-0926-SM-3NB34 GTEx Tissue Sample Gene Expression Profiles 1.0 1.59108 SUM52PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.772302 outer SZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.880246 BRD-K37283718 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53173 H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Precancerous Conditions CTD Gene-Disease Associations 1.0 1.24496 oral epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.992379 CACO-2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.974 PKIA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35144 GSE60217_1_v_10_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null Jun JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.4825 BRD-K51515697 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4668 19139136-TableS3 GeneSigDB Published Gene Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4863-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE135514_8_v_0_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null acebutolol-1911 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Stomach cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.11 MESSA CCLE Cell Line Gene CNV Profiles -1.0 -1.82458 COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.981653 YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WH7G-1626-SM-4LVMY GTEx Tissue Sample Gene Expression Profiles 1.0 2.46023 16540645-Table3 GeneSigDB Published Gene Signatures 1.0 null GTEX-S3XE-2026-SM-3K2B5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61962 tight junction assembly GO Biological Process Annotations 2025 1.0 null GTEX-S4Z8-1726-SM-3K2AX GTEx Tissue Sample Gene Expression Profiles 1.0 0.954605 BRD-K96505704 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2376 CRCGN008_HEPG2_24H:J06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.339 alimentary canal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PAR polarity complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.214 niridazole-4621 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null harman-4408 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-QVUS-0011-R3A-SM-3GAFD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.865672 Lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.337 QA-50-YO37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.727073 clorsulon-1735 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cell-cell junction assembly GO Biological Process Annotations 2015 1.0 null TRMT6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27532 ZL-34 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.884 Tight junction COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 NDUFB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32975 E2F6 JASPAR Predicted Transcription Factor Targets 1.0 null PMC12714181-pone.0337892.s004.xlsx-Supplementary_Table2-S4_Table_Differential_expressed_genes_between_si-CEBPB_and_si-NC_HCT116_cells_CEBPB Rummagene Transcription Factor Associations 2026 1.0 null COLO 792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.10554 PKNOX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.1564 skeletalmuscle_a HPA Tissue Sample Gene Expression Profiles -1.0 -2.7691 GTEX-WI4N-1126-SM-3LK7Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.839437 OVMANA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.855817 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7421-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE242555_1_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null YD-49-HM53_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.970349 GSE213588_9_v_1_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null ventrolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.31008 phentolamine-2362 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null lysergol-4966 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN017_MCF10A.WT.HP_24H:P08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5153 methocarbamol-2274 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null KIF17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.239 H3K9ac_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 8223_SNRPA1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.00501 Prostate adenocarcinoma_PRAD_TCGA-HC-8265-01A-11R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null G61 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.90213 Kidney renal clear cell carcinoma_KIRC_TCGA-B2-5641-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null seminiferous tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.193311 CRCGN008_HEPG2_24H:N03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.09775 amorolfine LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.16107 Ovarian surface epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.717 H3K36me3_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Epithelioid Mesothelioma, Malignant DisGeNET Gene-Disease Associations 1.0 null vestibular nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.929369 H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null SNRPB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11584 HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08701 GSE48812_2_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null duodenal mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.442194 Bronchial epithelium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.039 H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 16109776-TableS1 GeneSigDB Published Gene Signatures 1.0 null NE-20-WM78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.400079 caudal division of IPC (area 39) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.828139 LN428 CCLE Cell Line Gene Expression Profiles 1.0 1.70196 AA-58-FJ71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.210394 nicotinic acid-5301 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XAJ8-1026-SM-47JY9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0776 Acute Myeloid Leukemia_LAML_TCGA-AB-2872-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE133213_6_v_13_znrf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null duodenum HPA Tissue Gene Expression Profiles 1.0 1.72644 azathioprine-1945 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KP-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18915 GSE120595_5_v_1_arid2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Sarcoma_SARC_TCGA-DX-A3UE-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TEN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30133 VZ in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.29696 GTEX-XXEK-0926-SM-4BRWH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16238 gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.519961 BRD-K00300115 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42728 BRD-K68558540 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4884 primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.91548 NCI-H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.37924 GTEX-RM2N-0008-SM-48FF3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1702 Small_Intestine-enterocyte of epithelium of small intestine Tabula Sapiens Gene-Cell Associations 1.0 11.1871 ovary TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068042 HA-22-CY42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.354954 chlorpromazine-5577 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-D-Enh_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null Hypertrophy CTD Gene-Disease Associations 1.0 1.6934 Dysentery DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.009 nifedipine-1692 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null clidinium bromide-3476 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null emboliform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.11839 dorsal lateral geniculate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.3497 Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.285 CRCGN014_HEPG2_3H:F03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.44381 mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.619814 Perturb_12891_KD_Setd2_SRP035252 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 11.7295 Graft-Vs-Host Disease DisGeNET Gene-Disease Associations 1.0 null TCERG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98092 anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.870744 BRD-K88195243 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17137 GTEX-U8XE-1126-SM-3DB8W GTEx Tissue Sample Gene Expression Profiles -1.0 -0.92128 ornidazole-2109 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HT-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.90777 BRD-A94366206 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16174 BRD-K59831227 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.63969 BA-95-YU85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.374087 DA-66-OE69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.21648 zardaverine-4209 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RMG-I Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.04112 GTEX-Q734-0226-SM-48U1A GTEx Tissue Sample Gene Expression Profiles 1.0 1.60791 Small intestine cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.465 VIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.17745 ZNF341 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.826 BRD-K20183527 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05847 trifluoperazine-5584 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung adenocarcinoma_LUAD_TCGA-55-7903-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AGPAT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90559 GSE242290_1_v_11_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null PMC8724844-bt-30-1-98-supple2.xlsx-Hallmark_pathways-NFKB1_NFKB1 Rummagene Transcription Factor Associations 2026 1.0 null NCCSTCK140 CCLE Cell Line Gene Expression Profiles -1.0 -1.80856 GTEX-WYJK-1726-SM-3NM9U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.72505 intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.395235 GTEX-OHPN-0011-R2A-SM-2I5FB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.828442 apical junction complex GO Cellular Component Annotations 2023 1.0 null Cell division site COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.246 BRD-K95877349 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41739 whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 GSE239373_0_v_1_mettl3_mouse RummaGEO Gene Perturbation Signatures -1.0 null ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null viscus TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 phenacetin-2832 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE179036_1_v_0_trim24_mouse RummaGEO Gene Perturbation Signatures -1.0 null 4718_LURAP1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.550842 Apical cytoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.792 CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.923334 SLITRK5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57631 GSE239578_5_v_7_cxadr_mouse RummaGEO Gene Perturbation Signatures -1.0 null Connective tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.337 disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.044181 Cell junction COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 gingival epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.548517 lobeline-1770 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null plicamycin_homo sapiens_gpl570_gse25127 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null regulation of intestinal D-glucose absorption GO Biological Process Annotations 2025 1.0 null mepyramine-7223 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null aztreonam-1435 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null anterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.987693 t67-small-intestine_consensus MoTrPAC Rat Endurance Exercise Training 1.0 1.49735 GTEX-RVPU-0011-R1A-SM-2XCAI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.87552 GSE133691_2_v_0_lgr5_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K47272214 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12449 GSE219195_0_v_5_rbm12_human RummaGEO Gene Perturbation Signatures 1.0 null GSE149123,GSE149128_2_v_0_cdk7_mouse RummaGEO Gene Perturbation Signatures -1.0 null BL-41 GDSC Cell Line Gene Expression Profiles 1.0 1.4434 mediodorsal nucleus of thalamus_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.74871 lateral orbital gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.60756 GTEX-TSE9-2626-SM-4DXV2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.956298 tanespimycin-521 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CTDP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15524 Renal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.313 A-CA-04-2009(H1N1)MA_Day1_22532695_GSE36328 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.34669 GTEX-PWOO-2326-SM-2S1PQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2172 GTEX-S33H-1826-SM-4AD65 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02981 disease GWASdb SNP-Disease Associations 1.0 0.030654 GATA3-21878914-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K39159284 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53408 TUBGCP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12771 H3K4me1_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE231648_0_v_5_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7477-01B-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K51228600 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06609 abnormal small intestine crypts of Lieberkuhn morphology MGI Mouse Phenotype Associations 2023 1.0 null Autosomal recessive nonsyndromic deafness DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.026 noretynodrel-1696 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE148692,GSE148695_1_v_0_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PSN1 CCLE Cell Line Gene Expression Profiles -1.0 -1.72025 H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K44521151 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.11055 Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.87858 Amputation Stumps DisGeNET Gene-Disease Associations 1.0 null TP53I13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23842 orbital frontal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.14657 ranitidine-5425 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GATA3-22897851-JUKARTE6-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SET-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.92806 BRD-K47370004 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23181 actin-based cell projection COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.475 PMC10684125-cm9-136-2712-s001.xlsx-Sheet1-NFKB1_NFKB1 Rummagene Transcription Factor Associations 2026 1.0 null HNF4A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLC39A10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09271 ATF2_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.081 GTEX-OXRN-0011-R10A-SM-2I5GC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02182 BRD-K42679620 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58057 GTEX-PWN1-1626-SM-2S1OL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71904 Lung squamous cell carcinoma_LUSC_TCGA-77-8150-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_3415_KO_Cdx2_SRP093647 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -15.4471 MEDNIK syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.192 GTEX-R55G-0226-SM-48FEI GTEx Tissue Sample Gene Expression Profiles 1.0 0.945305 APUD cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.457 connective tissue cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.056541 short bowel syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.671925 PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-GeneID_AR Rummagene Transcription Factor Associations 2026 1.0 null tight junction assembly GO Biological Process Annotations 2015 1.0 null H513 COSMIC Cell Line Gene Mutation Profiles 1.0 null PIK3CA_mutant_27_GDS4053 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.77106 GTEX-RVPU-2326-SM-2TF6R GTEx Tissue Sample Gene Expression Profiles 1.0 0.943052 POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.523 Pavement epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.016 GSE128730_7_v_5_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null TRMT13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32253 HCC1187 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.893853 FOXA2 ChEA Transcription Factor Targets 1.0 null Disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.043 RMGI CCLE Cell Line Gene CNV Profiles -1.0 -1.8133 JD-81-YX02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.265081 ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.880113 Cluster of actin-based cell projections COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.837 BRD-K57356416 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04966 M-1 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.965974 PDCL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42721 GSE169152_5_v_7_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K66248685 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65334 GSE113817_0_v_1_bach1_human RummaGEO Gene Perturbation Signatures 1.0 null CDC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57379 SERINC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17317 ZNF182 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3657 NCIH322 CCLE Cell Line Gene CNV Profiles -1.0 -2.30595 MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.51981 TIMM23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35715 amiodarone-4657 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 5832_NSRP1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.594745 Musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.332 cell-cell junction organization GO Biological Process Annotations 2015 1.0 null ivermectin-7206 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-W5WG-1926-SM-4KKZK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29673 epirizole-1681 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K09227140 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.37738 SDHD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.13964 GTEX-O5YV-2026-SM-2D7VS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.94603 H3K4me1_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null wortmannin-5603 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_6_KO_Rnf114_SRP301146 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.86167 TTK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58584 globus pallidus, internal segment, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.41253 GSE189789_0_v_1_oridonin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_HEPG2_48H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.59653 medial vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.937821 KLF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19077 Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7593-01A-11R-2232-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE205976,GSE205978_2_v_5_cep83_human RummaGEO Gene Perturbation Signatures 1.0 null isoxsuprine-1485 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null meclofenoxate-2546 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null OVCAR-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.853527 BRD-K18519876 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11221 Actomyosin contractile ring COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.349 GSE198794_2_v_1_usp18_human RummaGEO Gene Perturbation Signatures 1.0 null SH2D5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04521 neomycin-2066 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A44B-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 7839_SF3B5_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.03773 Connective tissue cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.212 GTEX-RVPU-2426-SM-2XCAR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7211 supporting cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.198864 GTEX-XOT4-0326-SM-4B66S GTEx Tissue Sample Gene Expression Profiles 1.0 1.61803 Prostate adenocarcinoma_PRAD_TCGA-YL-A8S8-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null allantoin-1678 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SNU398 DepMap CRISPR Gene Dependency 1.0 2.66518 JB-75-NC66_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.85536 integral component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.194371 GA-61-GX82_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.211218 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4116-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KELLY CCLE Cell Line Gene CNV Profiles -1.0 -1.6965 WM88 DepMap CRISPR Gene Dependency 1.0 3.89767 Pleural cavity TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.852 GSE205316,GSE205317_0_v_1_nrip1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Arrhythmogenic Right Ventricular Cardiomyopathy_Myocardial tissue_GSE4120 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.87978 GSE174498,GSE174500_0_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS Rummagene Transcription Factor Associations 2026 1.0 null abamectin-7218 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 9656_USP39_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.785609 H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE244072_10_v_8_tfeb_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-Q734-1626-SM-48U1B GTEx Tissue Sample Gene Expression Profiles 1.0 1.80745 GTEX-U4B1-0326-SM-3DB8K GTEx Tissue Sample Gene Expression Profiles -1.0 -0.989823 cerebellar cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.962063 B800-850 antenna complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.592 GSE81193_3_v_5_irf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null orbital frontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.34182 mephenytoin-6275 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE258991_5_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null posteroventral (inferior) parietal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.891723 Colon sigmoideum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.892 KMS-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.947404 Brain Lower Grade Glioma_LGG_TCGA-DU-6407-02B-11R-A36H-07,TCGA-DU-6407-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PWCY-1026-SM-48TD4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.832866 Perturb_16527_KO_Eed_SRP075353 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.09867 H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null pilocarpine-6741 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 7186_RBMX2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.585847 H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE95077_1_v_0_amiloride_human RummaGEO Drug Perturbation Signatures 1.0 null GSE158834_0_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GATA2-19941826-K562-human ChEA Transcription Factor Binding Site Profiles 1.0 null ramipril-6792 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null layer IIIu of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.64387 BRD-K20024170 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09653 GSE203308_15_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K74486924 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76155 SNU1544 DepMap CRISPR Gene Dependency 1.0 3.20488 GTEX-XPVG-1826-SM-4B64X GTEx Tissue Sample Gene Expression Profiles 1.0 1.71562 EBC1 DepMap CRISPR Gene Dependency 1.0 15.7716 Lung squamous cell carcinoma_LUSC_TCGA-60-2726-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Enteroendocrine cell_Intestinal crypt_Mouse CellMarker Gene-Cell Type Associations 1.0 null CDC27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72591 Peritoneal mesothelioma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.404 GTEX-T6MN-0526-SM-32PMS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40587 BRD-K86155080 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15206 BRD-K05950670 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03559 Gonadal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.106 SNU5 CCLE Cell Line Gene CNV Profiles 1.0 2.07465 DD-36-YH76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.14126 GSE202434,GSE202438_4_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K41451401 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40381 A4/FUK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.850723 Intestinal mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.976 medial ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.886544 striatum_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.845362 BRD-K56520530 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35295 VB-48-KG22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.266654 GTEX-O5YT-0326-SM-32PKA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16702 TBL1XR1 ENCODE Transcription Factor Targets 1.0 null BRD-K46458719 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03707 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HI-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXO1-25302145-T-LYMPHOCYTE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null RAD51B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.50477 Perturb_1728_KO_Mdmx/Spi1_SRP301763 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 corl23 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.708 abnormal enterocyte physiology MPO Gene-Phenotype Associations 1.0 null ZNF263_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAL1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UJMC-1926-SM-3GADS GTEx Tissue Sample Gene Expression Profiles 1.0 0.925958 PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3 Rummagene Transcription Factor Associations 2026 1.0 null abnormal digestive system morphology MPO Gene-Phenotype Associations 1.0 null HES3_KO_GSE64449_186_mouse_Min6 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null JAK1_knockdown_160_GSE37012 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.83181 Diencephalon TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.225 IEC-6 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.182 isoniazid-1399 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN015_HEPG2_48H:G19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.34465 GSE48812_0_v_1_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K28135985 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14315 pindolol-1392 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K91564773 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42172 EBF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.4378 G96 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.43209 MZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.27327 BRD-K59984972 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2243 Blood cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SETDB1 ENCODE Transcription Factor Targets 1.0 null NCOR-22424771-293T-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K69393995 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35482 diclofenac-7215 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null amitriptyline-167 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K97255584 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10331 Calcium HMDB Metabolites of Enzymes 1.0 null lactic acidosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.289027 GTEX-SN8G-0226-SM-4DM6B GTEx Tissue Sample Gene Expression Profiles 1.0 1.17038 L-363 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.48386 OC-314 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K84601599 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02263 posterior (caudal) superior temporal cortex (area 22c)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.10467 8820_TERF2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.781705 LYNX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02601 rolitetracycline-5331 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ZNF232 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06139 Jejunal mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.09 H3K4me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null lateral plasma membrane GO Cellular Component Annotations 2015 1.0 null GSE206270_1_v_3_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null PPP1R26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11854 bisacodyl-5677 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cefaclor-4967 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HS 578T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.18426 urinary tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.338545 GSE162688_3_v_2_pink1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K65361030 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23857 BRD-K99127896 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09416 BRD-K20026212 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40758 Muscularis mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.673 mdck cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.55607 BRD-K65250438 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31882 ST6GAL1_Deficiency_GDS3151_608_mouse_Mammary tumors GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K16136457 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55585 DorsalRootGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.73893 H3K36me3_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_14934_KO_Ythdf2_SRP254797 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.20982 BRD-A61014366 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19892 ascorbic acid-1610 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null lung HPA Tissue Protein Expression Profiles -1.0 -0.726527 Small_Intestine-paneth cell of epithelium of small intestine Tabula Sapiens Gene-Cell Associations 1.0 1.50919 Esophageal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.885 GSE201270,GSE201272_5_v_1_mybl2_human RummaGEO Gene Perturbation Signatures 1.0 null cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-Q734-1426-SM-48TZQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.19553 GTEX-P4QS-0926-SM-48TBS GTEx Tissue Sample Gene Expression Profiles 1.0 1.12999 H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XPVG-2726-SM-4B66W GTEx Tissue Sample Gene Expression Profiles 1.0 1.14022 Intestinal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.616 GTEX-UJHI-1726-SM-3DB9B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28651 reticular nucleus of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.55433 Bladder Urothelial Carcinoma_BLCA_TCGA-HQ-A2OF-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null chr7_101248115_C_G_b38 GTEx eQTL 2025 1.0 2.00183 GTEX-WI4N-1426-SM-3LK7H GTEx Tissue Sample Gene Expression Profiles 1.0 1.12173 hsa-miR-3189-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 Diethylnitrosamine CTD Gene-Chemical Interactions 1.0 null benfluorex-2621 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Autosomal recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.203 GSE120595_0_v_1_arid2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE110178_1_v_3_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures 1.0 null T24 BioGPS Cell Line Gene Expression Profiles -1.0 -0.835056 KPL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09362 bicellular tight junction GO Cellular Component Annotations 2023 1.0 null GTEX-WHPG-2226-SM-3NMBO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44646 KO52 CCLE Cell Line Gene CNV Profiles -1.0 -2.14232 intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 clomipramine-1566 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K31589685 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12541 myc_20940306_e13dot5_erythroblast_purified_from_liver_gof_mouse_gpl6885_gse18558 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.289608 H3K27ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.87383 2120_DDX41_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.58436 GTEX-T8EM-0826-SM-4DM76 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.898139 7833_SF3A2_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.00779 Irritable bowel syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.555 TECPR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.15944 cell-cell junction GO Cellular Component Annotations 2015 1.0 null Tight junction KEGG Pathways 2026 1.0 null MXI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PFKM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24288 guanethidine-5731 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Coelom TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.629 Biliary tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.112 FEZF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 52.7698 Acute Myeloid Leukemia_LAML_TCGA-AB-2886-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.585 lymph node HPA Tissue Protein Expression Profiles -1.0 -1.15749 BRD-K20091931 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.29532 GSE180200,GSE180201_5_v_1_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE213588_10_v_4_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K80296876 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25943 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A7DU-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11976269-41375_2025_2519_MOESM3_ESM.xlsx-ChIP_GATA2_Cluster_A-GeneName_GATA2 Rummagene Transcription Factor Associations 2026 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-A4BX-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null plagl2_17983586_small_intestine_lof_mouse_gpl1261_gds3010 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.94112 BRD-K40143134 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51087 GSE101239_5_v_1_valproic acid_mouse RummaGEO Drug Perturbation Signatures -1.0 null NR2F2 ENCODE Transcription Factor Targets 1.0 null Intestinal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.395 ES-I3 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 0.908443 cell junction assembly GO Biological Process Annotations 2015 1.0 null Perturb_13306_KO_Hnf4a/Cdx2_SRP049189 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -13.2632 Prestwick-689-2514 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-QMR6-0011-R7A-SM-32PKL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.913164 caudal ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.993993 GTEX-XXEK-1026-SM-4BRUW GTEx Tissue Sample Gene Expression Profiles 1.0 2.36177 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7413-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC7300082-41598_2020_66556_MOESM11_ESM.xlsx-Supplementary_Table_10-NFKB1_NFKB1 Rummagene Transcription Factor Associations 2026 1.0 null cotinine-2011 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 496100532_FWM_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.03901 mRNA_ZSCAN4C_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null LRP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12418 GSE199204,GSE211619_4_v_3_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null occluding junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.58852 cell-cell adhesion GO Biological Process Annotations 2015 1.0 null Bipolar Disorder_frontal cortex_GSE5389 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.6193 RERFLCSQ1 DepMap CRISPR Gene Dependency 1.0 4.86356 Hyperglycemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.23 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7410-01A-21R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null betamethasone-5328 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SNUC1 CCLE Cell Line Gene Expression Profiles 1.0 1.87878 MC-IXC GDSC Cell Line Gene Expression Profiles -1.0 -1.45924 Mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.207 ONS76 DepMap CRISPR Gene Dependency 1.0 5.69642 SNAI2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.4247 Adenoma, Liver Cell CTD Gene-Disease Associations 1.0 1.16833 ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.618627 H3K36me3_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null orbital frontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.0055 GSE159049_1_v_0_sox2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE149442_1_v_0_gdpd3_mouse RummaGEO Gene Perturbation Signatures -1.0 null chloramphenicol-1837 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TRAF3IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.79478 Pancreas disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.01 STAT6_01_50 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.60148 GSE133213_6_v_5_znrf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K44224150 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09886 amylocaine-1909 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null tm-4 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.637999 benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040992 Kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.278 PMC9882185-media-4.xlsx-Neuron_KD-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null WDR43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20528 milrinone-7210 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE171837_0_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures -1.0 null BA-84-WN26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.238191 cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.301254 CF-65-GU65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.468543 8126_SLU7_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.796607 IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.2058 Lung adenocarcinoma_LUAD_TCGA-MP-A4T9-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE133213_11_v_3_znrf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null TE6 CCLE Cell Line Gene CNV Profiles -1.0 -1.86073 prilocaine-2352 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null primary auditory cortex (core)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.13374 duodenum TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO Biological Process Annotations 2023 1.0 null Uterine cervix TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 corpus callosum Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.32234 Liver Neoplasms, Experimental CTD Gene-Disease Associations 1.0 1.65467 PMC4904359-12915_2016_267_MOESM12_ESM.xlsx-LEUTX_DOWN-All_significantly_up_regulated_genes_determined_by_DESeq2_fold_change_greater_than_1_25_going_down_from_an_FPKM_of_at_least_2_LEUTX Rummagene Transcription Factor Associations 2026 1.0 null valproic acid-5574 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null peripheral nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.098549 piracetam-5043 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-T2IS-0011-R3A-SM-32QPB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03238 GEM Pathway Commons Protein-Protein Interactions 1.0 null SOX9-25088423-EMBRYONIC-GONADS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null cardiovascular system disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.197766 BRD-K68470956 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47665 heart GTEx Tissue Gene Expression Profiles -1.0 -0.969766 EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.233423 valproic acid-5600 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null JUN JASPAR Predicted Transcription Factor Targets 1.0 null abnormal jejunum morphology MPO Gene-Phenotype Associations 1.0 null ANAPC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33777 tolazoline-4262 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_6252_KO_Pcgf1/Pcgf6_SRP269225 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -15.5679 yohimbine-6777 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-QV31-1626-SM-2S1QC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.868783 EBF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.2356 EWSR1-FLI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 118.752 levonorgestrel-2547 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE136894_1_v_0_psen1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BA-84-WN26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.269887 ciprofloxacin-5299 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HCC1419 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.49411 Prostate adenocarcinoma_PRAD_TCGA-KC-A7F5-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K94777797 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11785 AR ChEA Transcription Factor Targets 1.0 null caudal ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.832548 LU99 CCLE Cell Line Gene CNV Profiles -1.0 -2.86737 Perturb_728_OE_QKI5_SRP293637 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 POLR2A_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K42575648 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45483 amprolium-1979 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CB-31-UO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.55626 BRD-K16305571 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24238 VZ in subcallosal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.86979 MXI1 ENCODE Transcription Factor Targets 1.0 null GTEX-XUZC-1426-SM-4BRV3 GTEx Tissue Sample Gene Expression Profiles 1.0 3.14822 TMEM139 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03004 SKM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.937643 GSE119564_2_v_3_zfp217_mouse RummaGEO Gene Perturbation Signatures 1.0 null PKBalpha_KO_GDS1784_194_mouse_Embryonic fibroblasts (MEFs) - 2h GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE131565_1_v_0_cannabidiol_human RummaGEO Drug Perturbation Signatures 1.0 null EKC/KEOPS complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.538 HSC-4 GDSC Cell Line Gene Expression Profiles -1.0 -1.72535 GTEX-RVPU-0011-R3A-SM-2XCAE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37893 Kidney Chromophobe_KICH_TCGA-KN-8424-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GNPNAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01743 GSE140651,GSE140653_2_v_6_med1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE48812_11_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null H3K36me3_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4078-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Enteroendocrine precursor cell_Intestinal crypt_Mouse CellMarker Gene-Cell Type Associations 1.0 null cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.180367 Perturb_12844_KO_Ehmt2_SRP269502 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 15-delta prostaglandin J2-1172 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DX-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A6HP-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Parathyroid gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 dexamethasone-374 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null C-33 A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Perturb_158_KD_Prmt1_SRP360688 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -15.9209 BLTP3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41953 GTEX-RVPU-0008-SM-3NM8B GTEx Tissue Sample Gene Expression Profiles -1.0 -0.891741 Basal plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.285 RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LLC-PK1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.147 Rectum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 POLR2A_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.84506 PPARG-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-TSE9-0011-R7A-SM-3DB7P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00505 Sense organ TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.074 PRDM5-23873026-MEF-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-U8XE-0826-SM-4E3J1 GTEx Tissue Sample Gene Expression Profiles 1.0 2.08856 GSE240386,GSE242143_8_v_3_morc2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE199921_1_v_0_romidepsin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-OOBJ-0926-SM-48TDO GTEx Tissue Sample Gene Expression Profiles 1.0 0.935428 CRCGN010_HEPG2_24H:A04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1411 NCI-H2596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.84453 GSE199204,GSE211619_4_v_7_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null Leukemia_chronicMyelogenousK-562 BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.16237 prednicarbate-5544 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K10638173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54016 LP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.984357 thalidomide-5990 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE147662_3_v_5_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null mediodorsal nucleus of thalamus_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.831637 H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K22246901 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.9831 ventrolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.41045 Crypt TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.227 H3K36me3_NT2-D1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55E-0526-SM-2TC6B GTEx Tissue Sample Gene Expression Profiles -1.0 -2.81158 BRD-K72591075 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01313 H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YTHDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42542 primary auditory cortex (core)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.0832 GTEX-OXRL-0326-SM-2I3F2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04475 Kidney Chromophobe_KICH_TCGA-KO-8403-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-P44H-0011-R10A-SM-2XCEK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15972 TEKT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92586 NCI-H1792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.47364 GTEX-XPVG-0826-SM-4B654 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02569 enterocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.461465 Perturb_814_KD_Dnmt3a_SRP119259 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 11.19 nomifensine-2062 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Oral epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.131 GTEX-XV7Q-2126-SM-4BRVX GTEx Tissue Sample Gene Expression Profiles 1.0 1.28715 GSE157960_0_v_1_progesterone_mouse RummaGEO Drug Perturbation Signatures 1.0 null Stomach disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.16 BRD-K94145457 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40796 NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.0814 GTEX-RU1J-1726-SM-2TF5S GTEx Tissue Sample Gene Expression Profiles -1.0 -0.996875 GTEX-XK95-0426-SM-4AT4R GTEx Tissue Sample Gene Expression Profiles 1.0 1.30336 6550_POLR2I_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.716329 lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.41828 BRD-K48699175 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62989 H3K4me1_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE95386_0_v_1_trim24_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF528 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.224 wortmannin-5240 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Atrophy CTD Gene-Disease Associations 1.0 1.26267 preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.903437 BRD-K76885311 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11856 PANC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.19836 GSE89767_6_v_5_cebpa_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE157594_6_v_4_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-VW-A8FI-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE144231_2_v_1_cxcr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K83115435 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44373 BRD-K73202406 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57688 GTEX-OXRO-0011-R9A-SM-3NB1X GTEx Tissue Sample Gene Expression Profiles 1.0 1.14917 GSE225656_2_v_3_tsc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE229914_1_v_3_keap1_human RummaGEO Gene Perturbation Signatures 1.0 null SNU283 CCLE Cell Line Gene Expression Profiles 1.0 1.57692 cyclopenthiazide-7325 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-WWYW-0526-SM-3NB2W GTEx Tissue Sample Gene Expression Profiles -1.0 -0.968754 496100322_FWM_possible Alzheimer's disease_no TBI_100+_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.16773 globus pallidus, external segment, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.20794 Colorectal adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.001 GTEX-WY7C-2526-SM-3NB2N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46519 amoxapine-2013 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.144 KLF15_Deficiency_GDS2687_648_mouse_Liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null U-698-M GDSC Cell Line Gene Expression Profiles 1.0 2.03866 ventrolateral prefrontal cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.22056 PF-59-CY33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.202854 GSE164087_0_v_1_jmjd8_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung endothelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.807 Olfactory bulb TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.059 GSE139540_3_v_1_menadione_human RummaGEO Drug Perturbation Signatures 1.0 null GSE48812_4_v_1_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null PMC8185471-mmc4.xlsx-D4-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_4_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15 Rummagene Transcription Factor Associations 2026 1.0 null Virion - Hepatitis viruses KEGG Pathways 2026 1.0 null Collagenous colitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.748 Microglial cell_Brain_Human CellMarker Gene-Cell Type Associations 1.0 null hsa-miR-887 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 ventrolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.04683 globus pallidus, external segment, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.09274 59M CCLE Cell Line Gene CNV Profiles -1.0 -1.45682 cefadroxil-4080 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Thymus-mesothelial cell Tabula Sapiens Gene-Cell Associations 1.0 0.088107 GTEX-OIZG-1326-SM-2HMIQ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.16532 GSE152432_3_v_2_zrsr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE48812_4_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null NR2F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 65.1486 FOXA2-19822575-HEPG2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Breast cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.235 inferolateral temporal cortex (area TEv, area 20)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.896844 9843_WDR77_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.531628 PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS Rummagene Transcription Factor Associations 2026 1.0 null EVSAT CCLE Cell Line Gene CNV Profiles 1.0 1.73009 FA-88-II68_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.968112 Perturb_5526_KO_Crtc1_SRP279598 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 14.5452 GTEX-OHPL-1326-SM-3MJGG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.857903 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A5W4-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11237033-41419_2024_6873_MOESM3_ESM.xls-Supplementary_Appendix_2-NFKB1_NFKB1 Rummagene Transcription Factor Associations 2026 1.0 null CAV1_Deficiency_GDS3551_559_mouse_Hearts GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null SFRP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12094 GSE131649_2_v_11_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-S4Z8-0126-SM-4GICC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.859134 Perturb_12846_KO_Setd1b_SRP081141 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -9.29187 cell junction GO Cellular Component Annotations 2015 1.0 null dipivefrine-6766 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null primary motor cortex (area M1, area 4)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.06275 SNU175 CCLE Cell Line Gene Expression Profiles 1.0 1.72807 BRD-K19046167 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02447 MPDU1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58786 GB-57-XV52_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.206134 ovarian surface epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.479702 HCC2998 DepMap CRISPR Gene Dependency 1.0 2.0949 Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.282 POLR2A_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P78B-1926-SM-3P616 GTEx Tissue Sample Gene Expression Profiles 1.0 1.23532 BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.33366 alimentary canal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.930621 iproniazid-2125 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Enteroendocrine cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.458 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HQ-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-W5WG-1326-SM-4LMI9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.837903 GSE145323,GSE145324_3_v_2_rfx3_mouse RummaGEO Gene Perturbation Signatures -1.0 null Leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 wt1_17420277_e11dot5_urogenital_ridge_lof_mouse_gpl1524_gds2747 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.431091 LPXN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29691 GATA2-19941826-K562-HUMAN ChEA Transcription Factor Targets 2022 1.0 null large intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.442578 Female reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.123 chitin-based extracellular matrix COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.029 PSMG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60783 BRD-K10416099 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.9456 Sarcoma_SARC_TCGA-DX-A6YZ-01A-12R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nordihydroguaiaretic acid-5220 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K36me3_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null naftidrofuryl-2622 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null domperidone-1301 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null acquired metabolic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.059793 bone marrow HPA Tissue Protein Expression Profiles -1.0 -1.15749 GSE171837_1_v_2_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WXYG-2526-SM-3NB3F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17695 molecular_function GO Molecular Function Annotations 2015 1.0 null NUGC4 CCLE Cell Line Gene Expression Profiles 1.0 1.90252 BRD-K56837922 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7412 Sarcoma_SARC_TCGA-SI-AA8C-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE181966_5_v_3_has2_mouse RummaGEO Gene Perturbation Signatures -1.0 null HUES64_Cell_Line Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.0296 Acute Myeloid Leukemia_LAML_TCGA-AB-2840-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE140576_0_v_2_plag1_mouse RummaGEO Gene Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.959697 D283MED CCLE Cell Line Gene CNV Profiles -1.0 -1.87601 OUMS-23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13894 H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null STAT2_02_18 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.58659 LY-294002-1177 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 7838_SF3B4_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.613659 SNX8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35925 NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.54757 GTEX-SUCS-1726-SM-32PM8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00657 Perturb_16676_KO_Cst3_SRP281188 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.96896 GTEX-XXEK-1426-SM-4BRW1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.51803 PMC6962646-mmc2.xlsx-StemCell_Genesets_2018-ZNF257_ZNF257 Rummagene Transcription Factor Associations 2026 1.0 null GSE179531_1_v_0_metformin_mouse RummaGEO Drug Perturbation Signatures 1.0 null PPP1R11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64414 GTEX-X4XX-0926-SM-46MV7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.237 CRCGN009_HEPG2_24H:G06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.14231 GTEX-Q2AH-1826-SM-2S1Q2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51966 FLI1-26923725-CHIP-SEQ-MACROPHAGESS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PHACTR1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00485272 DC-70-EK34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.46368 GSE152432_1_v_2_zrsr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OHPN-0011-R4A-SM-2I5FD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17113 FOXA2-19822575-HepG2-human ChEA Transcription Factor Binding Site Profiles 1.0 null ranitidine-2251 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mesothelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.623 GTEX-PW2O-1726-SM-2S1OO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21969 primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.9509 Thymus BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.850874 NCIH1930 CCLE Cell Line Gene Expression Profiles -1.0 -2.51762 BHY GDSC Cell Line Gene Expression Profiles -1.0 -1.42838 BRD-K25596713 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09939 metacycline-7321 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2AphosphoS2_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE213588_9_v_12_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null Alveolar mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.543 phenacetin-3992 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE158715_2_v_4_cyp1b1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ventricular (matrix) zone of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.992008 GSE104508_2_v_1_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null dilazep-2333 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null spleen GTEx Tissue Gene Expression Profiles 1.0 0.833959 GSE114690_2_v_3_tnfsf14_mouse RummaGEO Gene Perturbation Signatures 1.0 null EKVX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.856214 GSE147876,GSE147877_2_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null cerebellar cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.83806 tremorine-1579 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE60217_1_v_0_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null Colonic epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.717 NCIH1563 CCLE Cell Line Gene CNV Profiles -1.0 -1.57966 primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.6658 cis-Golgi network COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.7 ion transport GO Biological Process Annotations 2015 1.0 null Pyloric cecum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.403 GSE213588_10_v_0_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN015_MCF10A.WT.HP_24H:J23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.03398 GTEX-QV44-1825-SM-447CF GTEx Tissue Sample Gene Expression Profiles 1.0 1.39771 Bile duct disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.115 NCI-SNU-5 COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 GTEX-OXRN-1426-SM-3LK5U GTEx Tissue Sample Gene Expression Profiles 1.0 0.887387 Claudin, conserved site InterPro Predicted Protein Domain Annotations 1.0 null H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE193402_0_v_3_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YN-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal enterocyte cell number MPO Gene-Phenotype Associations 1.0 null SLC30A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.46472 NCI-H1623 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.10303 Diarrhea DisGeNET Gene-Phenotype Associations 1.0 null Pleura TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.315 GTEx Esophagus 20-29 vs 50-59 GTEx Tissue-Specific Aging Signatures 1.0 12.9196 fluphenazine-7234 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.14214 HCC2998 GDSC Cell Line Gene Expression Profiles 1.0 2.541 mouth TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.107068 Colon descendens TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.538 TD-29-IN36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.73988 H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null abnormal intestine physiology MPO Gene-Phenotype Associations 1.0 null GTEX-S7PM-0526-SM-3NM92 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90122 GTEX-Q734-0626-SM-2I3EF GTEx Tissue Sample Gene Expression Profiles 1.0 0.836903 GTEX-WFON-0226-SM-3GIKR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14124 MCCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31522 ondansetron-6270 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 8-MG-BA COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-RVPU-0011-R9A-SM-3NM8E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.938639 LY-294002-6956 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GF-35-IT27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.254344 frontal pole, right, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.55897 Feather bud TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.762 EB-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17396 tubocurarine chloride-1738 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.12752 G111 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.43283 intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.999344 EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K48406740 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09998 GSE95077_1_v_4_amiloride_human RummaGEO Drug Perturbation Signatures 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5J5-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT6 MotifMap Predicted Transcription Factor Targets 1.0 null Syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.012 GSE180200,GSE180201_15_v_9_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.17133 GSE150669_2_v_1_roxadustat_mouse RummaGEO Drug Perturbation Signatures -1.0 null Small intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 0175029-0000-7392 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Erythrokeratodermia variabilis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.141 FOS::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.7357 miconazole-4960 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMS-12-BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.32652 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7418-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K82362034 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05854 PKBalpha_KO_GDS1784_197_mouse_Embryonic fibroblasts (MEFs) - 48h GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null t61-colon_consensus MoTrPAC Rat Endurance Exercise Training 1.0 10.0427 BRD-K37684893 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.20291 BRD-K28535931 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27555 LY-294002-5236 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_down-regulated_in_Myc_KD_hESC_AR Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5098-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null excretory gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-A4BW-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Colonic epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.909 POLR2A_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null shortened qt interval GWASdb SNP-Phenotype Associations 1.0 1.00059 GTEX-SNMC-1426-SM-2XCFM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6748 PMC9270251-mmc2.xlsx-2_Filtered_DEGs_Control_vs_KD_2-Gene_ID_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-RWS6-0326-SM-2XCAP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.985335 econazole-7305 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null mediodorsal nucleus of thalamus_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.959973 496100651_FWM_probable Alzheimer's disease_TBI_83_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.77114 GSE216043_10_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null primary motor cortex (area M1, area 4)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.08993 Calprotectin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.975 GTEX-R55C-1726-SM-3GADJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55132 mammalian phenotype MPO Gene-Phenotype Associations 1.0 null Sarcoma_SARC_TCGA-K1-A3PN-02A-11R-A22K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Epithelium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.039 Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H3-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null fasudil-343 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 8216_SNRNP200_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.819171 GTEX-WFON-1226-SM-3TW8F GTEx Tissue Sample Gene Expression Profiles 1.0 2.29253 hyoscyamine-1424 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BCB000038-7547 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Oligospermia CTD Gene-Disease Associations 1.0 1.17101 H3K27ac_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE193402_0_v_2_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null Hindgut TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.333 cefazolin-3426 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SMC1-22415368-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null pentamidine-639 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.054744 POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-C1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 3.23565 NCI-H2170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.10303 GSE137144_2_v_1_nlrp3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE221633_3_v_1_trim24_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RNOR-0526-SM-2TF4O GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05644 MZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.44179 Perturb_9503_KO_Crif1_SRP259100 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 12.3002 H3K4me1_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null dorsolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.973153 laudanosine-7030 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-U4B1-0126-SM-4DXSN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.857059 NCI-H2452 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.838707 GTEX-UJHI-0426-SM-3DB8Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01198 Perturb_13293_KO_Hdac3_SRP361157 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 GTEX-PLZ6-0126-SM-48TC6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.927791 GSE112860_3_v_6_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K06367273 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14281 GTEX-U412-2026-SM-4DXSI GTEx Tissue Sample Gene Expression Profiles 1.0 1.13502 fulvestrant-1146 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_120_KD_Ywhaz_SRP045772 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -13.958 H3K27ac_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00553534 BB-87-SF89_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.391519 SON CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22759 GTEX-X585-0426-SM-4E3JZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.07486 GSE206226_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null NPPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02714 Perturb_6584_KO_Clpp_SRP114840 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.30344 17297478-SuppTable6 GeneSigDB Published Gene Signatures 1.0 null apical junction complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.57016 H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE104508_2_v_3_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null Respiratory epithelium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.039 plasma membrane LOCATE Predicted Protein Localization Annotations 1.0 null internal male genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.106139 BRD-K10775155 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85446 SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.85294 LY2 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.20626 Ileal mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.835 imatinib_homo sapiens_gpl96_gds3048 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_5789_KO_Tnfrsf11a_SRP103818 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.82686 GSE114690_1_v_0_tnfsf14_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE147662_2_v_5_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-QDVJ-1926-SM-2S1PJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38642 GTEX-RN64-1626-SM-48FD7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.88622 CAMA-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.907674 Sarcoma_SARC_TCGA-DX-A48U-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE57871_1_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null Immune System Diseases CTD Gene-Disease Associations 1.0 1.06952 VZ in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.909587 PMC3023804-pone.0016344.s008.xls-S3_High_Confidence_PPAR_Peaks-Primary_Gene_ID_PPARA Rummagene Transcription Factor Associations 2026 1.0 null digestive/alimentary phenotype MPO Gene-Phenotype Associations 1.0 null H3K36me3_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-MF-A522-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cell part GO Cellular Component Annotations 2015 1.0 null ventrolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.15671 desoxycortone-6758 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NFKB1 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K93488589 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18167 EBC1 CCLE Cell Line Gene CNV Profiles 1.0 2.25413 Celiac Disease DisGeNET Gene-Disease Associations 1.0 null inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.40023 GTEX-WHSB-1826-SM-3TW8M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.66496 OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.921774 4152_INTS7_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.687827 GSE228413_2_v_3_mavs_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K36me3_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null procainamide-2618 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN015_HEPG2_48H:J23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.49958 Contractile ring COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.235 KCNIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01216 496100412_FWM_possible Alzheimer's disease_TBI_87_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.42152 Cell junction organization Reactome Pathways 2024 1.0 null BRD-K18101782 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12013 cell junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.23505 Perturb_9554_KO_Atg16l1_SRP159288 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -11.4726 cell part LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-P4QS-2026-SM-3NMCG GTEx Tissue Sample Gene Expression Profiles 1.0 0.832475 GSE110178_5_v_3_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures 1.0 null Cecum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.402 Gut epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.842 Junctional membrane complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.216 outer SZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.25499 gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.266413 oral epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.776079 CC-48-OM48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.261966 Acute Myeloid Leukemia_LAML_TCGA-AB-2898-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal enterocyte proliferation MGI Mouse Phenotype Associations 2023 1.0 null ketotifen-5842 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HCC33 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.831886 BRD-K20895937 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11414 CCNT2 ENCODE Transcription Factor Targets 1.0 null VD-88-MW70_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.415504 GTEX-T2IS-0011-R5A-SM-32QP4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26158 GTEX-XUZC-0226-SM-4BOO7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.919307 NCIH3255 CCLE Cell Line Gene CNV Profiles 1.0 1.33925 malignant ovarian surface epithelial-stromal neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.196459 IGF1_OE_GDS3484_538_human_MCF-7 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null calcium folinate-7401 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN014_HEPG2_3H:D21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.48514 PMC12703266-gutjnl-75-1-s002.pdf-32-CDX1_CDX1 Rummagene Transcription Factor Associations 2026 1.0 null GSE77108_8_v_2_saha_human RummaGEO Drug Perturbation Signatures 1.0 null Brain capillary endothelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.024 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I7-01A-21R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE226316_6_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null dyclonine-7423 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null irf8_00000000_splenic_cd11bplusgrdash1_hdash2b_gen_background_lof_mouse_gpl6887_gse39228 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.200271 Diarrhea DisGeNET Gene-Disease Associations 1.0 null MCM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46929 disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.197766 GTEX-S341-1926-SM-3K2BA GTEx Tissue Sample Gene Expression Profiles 1.0 0.889982 ME-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03697 H3K27ac_Duodenum Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null tomatidine-1754 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Intestinal gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.594