association	dataset	threshold value	standardized value
Brain Lower Grade Glioma_LGG_TCGA-FG-5963-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_852_KO_Igfbp7_SRP081229	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.70676
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC2866657-pone.0010547.s001.xls-ERG-high-GENES_DOWNREGULATED_IN_ERGhigh_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.96308
GTEX-QEL4-0008-SM-447AZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37739
K562_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162754
GSE87862_0_v_1_mov10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09936
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
inner CP in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.830208
GSE166783_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.64306
GSE224311_3_v_0_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
AB-18-YN11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210133
GSE153189_1_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE120370_4_v_1_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Alendronate sodium trihydrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016725
Sarcoma_SARC_TCGA-DX-A3UA-01A-12R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE189609_1_v_2_hax1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JIMT-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.945
hsa-miR-3163	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
PMC5527282-ncomms16041-s3.xlsx-M_LPS_-_gene_signature-Supplementary_Data_2_Full_gene_list_of_M_LPS_-_signatures_as_defined_in_figure_3_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
STAT4-19710469-TH1 cell mouse-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE164483_2_v_0_venetoclax_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K38209615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14755
BC-11-LL59_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222185
imatinib_homo sapiens_gpl96_gds3047	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OB-06-WW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311169
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.045
KDM5B-21448134-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-A84913188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88947
A101D_SKIN	CCLE Cell Line Proteomics	1.0	2.98682
VZ in midcingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.951833
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.858198
PMC3435504-msb201237-s2.xls-Supp_Table_4b-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.841779
BRD-K56022813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87181
PMC10898050-12967_2024_4947_MOESM2_ESM.xlsx-Table_S7-Table_S7_Differentially_expressed_genes_between_the_TCF7_CD8_memory_T_cells_and_the_other_memory_CD8_T_cells_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
888	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.6887
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UC-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Stomach Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
SMDT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15683
SKNMC	CCLE Cell Line Gene Expression Profiles	-1.0	-1.74146
ATXN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00545145
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33198
1180_CAPN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.748416
GSE63048_11_v_5_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75882
Kidney Chromophobe_KICH_TCGA-KN-8421-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CRCGN012_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.022
orbital frontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01232
CTCF_MEL cell line_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.46864
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_Roxadustat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197211
GTEX-UPJH-0526-SM-4IHK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32534
GSE166920_6_v_1_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K21610715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34731
GTEX-OXRN-2426-SM-2I5EQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4318
BRD-K56334280_S1367_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.347061
SARS-CoV_72Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.85556
Specific granule membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Brain - Hippocampus	GTEx Tissue Gene Expression Profiles 2023	1.0	1.81558
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.884
GSE236262_2_v_1_trim28_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4731-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
PML	ENCODE Transcription Factor Targets	1.0	null
BRD-K10540354	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30106
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K78712486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0737
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.268
BRD-K36531580	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36363
BRD-K01705159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10701
BRD-K05248348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02527
NR1I2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1862
ZNF384_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE179880_10_v_13_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BA-60-RH02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.348432
GSE225656_2_v_1_tsc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RUNX3	ENCODE Transcription Factor Targets	1.0	null
GSE88819_11_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-N7MS-0011-R11A-SM-2HMJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64865
cingulate gyrus, retrosplenial part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.37483
BRD-K57080016_-666_A375_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051045
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	1.0	3.63816
VZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.906963
DOK	DepMap CRISPR Gene Dependency	1.0	2.59732
A-CA-04-2009(H1N1)_36Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-3.73694
RCOR1	ChEA Transcription Factor Targets	1.0	null
PC-87-OG75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.283309
GTEX-X261-0011-R6B-SM-4E3J8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38725
BRD-K94521090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78658
4944_MED21_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.593002
GABPA_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4148_INTS3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.519496
CRCGN014_HEPG2_3H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1411
Ovary	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE210101,GSE210114_5_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K70428675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.39848
outer CP in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05865
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K24132293_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Colon adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
posterior (caudal) superior temporal cortex (area 22c)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.898271
BRD-K11652878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22301
EBF1	ENCODE Transcription Factor Targets	1.0	null
TCF4	ChEA Transcription Factor Targets	1.0	null
Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.32015
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K26251149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92672
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE143782_6_v_5_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
TNFRSF1B	MSigDB Cancer Gene Co-expression Modules	1.0	null
Perturb_14042_KD_HDAC1_SRP327853	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.10496
Yersinia enterocolitica food poisoning_Peyer's patch_GSE4764	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.71612
KYSE220	DepMap CRISPR Gene Dependency	1.0	2.02667
GSE237040_4_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXO3-23340844-DLD1-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889897
raphe obscurus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.31253
viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Labial gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.549
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A_48H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0087
GTEX-N7MS-2526-SM-2D7W3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15925
internal male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066212
GTEX-XPT6-2026-SM-4B64V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86853
t69-brown-adipose_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.0892
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Intracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GTEX-WHSE-0011-R1A-SM-3P5ZK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873138
hsa-miR-9	TargetScan Predicted Conserved microRNA Targets	1.0	0.37496
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE88819_7_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4285
GSE214514_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177509
GSE193993_0_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and neck squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.975
ENPP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00641927
GTEX-T5JW-1626-SM-3GADZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05327
CRCGN015_MCF10A.TP53.M_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0502
CRCGN014_HEPG2_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02038
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U4B1-0008-SM-4DXUW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14295
Brain Lower Grade Glioma_LGG_TCGA-HT-7857-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1963	CCLE Cell Line Gene Expression Profiles	-1.0	-2.77272
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE223008_6_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cephaeline-4651	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.284878
BRD-K50389815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68669
SYK_DEPLETION_GDS3609_36_human_MCF10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
HSD17B7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14441
Perturb_6481_KD_SERBP1_ERP118886	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.58489
GTEX-X4XY-0008-SM-46MVL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901913
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14574
GTEX-R55D-0626-SM-3GAD5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3944
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute lymphoblastic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
GSE48812_7_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K23817660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01773
BRD-K28907958_-666_A375_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IGROV1	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.11011
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.803181
A549_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140206
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
17023574-TableS1	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TCF4-18268006-LS174T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
17823238-TableS4b	GeneSigDB Published Gene Signatures	1.0	null
Uterine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.463
Lung squamous cell carcinoma_LUSC_TCGA-21-1072-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TGW	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.6369
Lung adenocarcinoma_LUAD_TCGA-62-8402-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81782
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-EF-5831-01A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRAPP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.64
FOXA1_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LF-35-CP32_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240938
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.39433
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	1.0	2.16915
outer CP in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.129
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.36995
H2BK12ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mental Disorders	CTD Gene-Disease Associations	1.0	1.74842
A375SKINCJ3	DepMap CRISPR Gene Dependency	1.0	3.94865
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.48042
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE142430_3_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
OVCAR4	BioGPS Cell Line Gene Expression Profiles	1.0	1.29205
PMC12729234-10194_2025_2222_MOESM1_ESM.xlsx-Table_S6-Table_S6_MR_results_of_the_significant_genes_from_human_brain_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.839118
H3K27ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HA-10-LJ21_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.29887
extracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7644-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE224131_5_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.835291
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40404
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_FLLL32_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177591
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158458_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OVCAR-3	GDSC Cell Line Gene Expression Profiles	1.0	1.4906
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE58724_1_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054986
GSE155305_3_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pancreatic adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.323
GTEX-XLM4-0008-SM-4AT4W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01477
PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-DMOG_-_HIF1A-gene_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0739
primary auditory cortex (core)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00337
RCOR1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tongue epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.192
GSE231799_2_v_1_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_SGI-1776 free base_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157537
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K82325043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05141
SCLC21H	CCLE Cell Line Gene Expression Profiles	-1.0	-2.14711
BRD-K18637162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21795
GSE242199_6_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.827
HEPA 1-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.735
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.487
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-98-8023-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CSNK1G3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0046358
Cytoplasmic vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CB-87-RB49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.475587
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.2979
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE210101,GSE210114_8_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7B1-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
PL45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.885281
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
USF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K49467822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56421
RPS27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03212
BRD-K49878220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08918
paracentral lobule, anterior part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.35536
FLI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE206729_3_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_JQ1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171321
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SETDB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0057777
RIMS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15514
FOXO3	ChEA Transcription Factor Targets	1.0	null
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.21961
BRD-K52075209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24943
Perturb_7946_KO_MED12_SRP201365	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.36659
IRF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00606171
BRD-K42308740_ST056792_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GFAP_OE_GDS1488_255_mouse_Olfactory bulb of  4 month old	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
cerebellar cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.863771
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.670303
GTEX-NL3H-0011-R3a-SM-2I3GL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26321
GSE226316_3_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Recycling endosome membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
E2A-27217539-CHIP-SEQ-RAMOS-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE207611,GSE207612_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE58724_3_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hodgkin's lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.287
GSE250089_0_v_3_epcam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7289-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XOTO-0526-SM-4B662	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00336
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7594-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CBL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00554557
BT-483 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.593
K562_Ofloxacin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177417
POU2F1::SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2832
MCF7_2-Methoxyestradiol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0119132
PMC3607232-mmc3.xlsx-RUNX1_targets_in_K562_and_SEM-x_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978629
Rectum adenocarcinoma_READ_TCGA-EI-6510-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ME-11-OJ38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209396
vascular disease	GWASdb SNP-Disease Associations	1.0	0.310698
PMC7468443-Data_Sheet_2.xlsx-DEG_6h_LPS-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A19500257_geldanamycin_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
outer CP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05191
extracellular region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K39965317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57825
IQSEC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0048788
Perturb_11663_KD_PPP1CB_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.44861
BRD-K55867695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56184
GTEX-TML8-1826-SM-32QOR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05658
VCaP	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.77123
PDE8A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00484188
K562_XAV-939_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0243875
Capivasertib_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0130613
Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CTCF_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.141
GTEX-TML8-0008-SM-4DXUI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82703
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DUSP10	Pathway Commons Protein-Protein Interactions	1.0	null
4939_MED17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.632986
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7053
DMS53	CCLE Cell Line Gene CNV Profiles	-1.0	-2.1976
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.061
CRCGN016_MCF10A.TP53.M_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.9129
EZH2	ENCODE Transcription Factor Targets	1.0	null
CREB1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE254517_1_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K76318449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0211
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7183-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K15939043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22237
Uveal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.086
H3K9ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC7606598-NIHMS1624889-supplement-1624889_Supp_Tab1-10.xlsx-S8_MR-JTI-geneid_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
amygdaloid complex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.958012
GSE147626_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
ASH2L-23239880-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-TMZS-0008-SM-47JWM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34301
arteriosclerosis	GWASdb SNP-Disease Associations	1.0	1.39396
primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.47331
BRD-K38977317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0975
BRD-K51956957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0072
BRD-K07303502_Arachidonyl trifluoro-methyl ketone_MCF7_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-TSE9-0011-R7A-SM-3DB7P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944321
primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.854209
GSE219195_1_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
BRD-K16062794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48114
MCF7_Luminespib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135194
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Lung squamous cell carcinoma_LUSC_TCGA-33-4589-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUDHL10	DepMap CRISPR Gene Dependency	1.0	2.87114
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
CHD7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K38929751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18274
BRD-K49148914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08793
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K45378289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13941
BRD-K74537058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22441
GSE195559_8_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SACS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06226
GSE142210_9_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UD-07-US73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.275002
PMC7648632__F2	PFOCR Pathway Figure Associations 2024	1.0	null
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01293
BRD-K39449072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60213
RCOR1-19997604-NEURONS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
496100470_HIP_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.36861
NAA10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41667
GSE216043_11_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152050,GSE152052_1_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OHPL-1626-SM-2HMIR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04674
Brain glioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.405
Brain Lower Grade Glioma_LGG_TCGA-DU-7012-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_BRD4770_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161481
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VP-A87J-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K96615474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03321
GSE154197_1_v_0_ints13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-2.06114
Neoplasm Metastasis	CTD Gene-Disease Associations	1.0	1.06952
CRCGN008_HEPG2_24H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1695
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.138
PLD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0069748
GSE84922,GSE84924_0_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K43719900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0032
Bladder	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.26216
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRKAG3_Mutation (R225Q)_GSE4067_390_mouse_Skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Cytoskeleton	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.486
PMC4165364-13059_2014_406_MOESM5_ESM.xls-Supp_Dataset_1-SUPPLEMENTARY_DATASET_1_AML3_AzaC_SigDiff_1147_Note_to_reviewers_-_view_these_files_as_xls_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal emotion/affect behavior	GWASdb SNP-Phenotype Associations	1.0	0.373121
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14285
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4757
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.171
GSE101239_5_v_0_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4694-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
K562_Barasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179243
FOXA1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XL-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE63048_11_v_12_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-335	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
BRD-K60834597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23491
GSE74251_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10T-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
supraoptic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.59962
GSE211983_1_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GABPA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZS-06A-12R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE77108_8_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14006
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
BRD-K71221636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11207
BTNL10P	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00644415
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HC-01-FD24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286456
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.55156
recycling endosome membrane	GO Cellular Component Annotations 2025	1.0	null
RCOR1-19997604-NEURONS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K51779559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60955
GTEX-XOTO-2926-SM-4B65G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01898
BRD-K63887881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4401
Brain cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.354
MCF7_Entacapone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155155
NCI-H82	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.3777
Thymus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.243
GSE155567_2_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE132408_1_v_3_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9061815-41422_2022_635_MOESM8_ESM.pdf-8-ASCL1_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K86593041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78453
Lung adenocarcinoma_LUAD_TCGA-44-2662-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Regulatory T (Treg) cell_Liver_Human	CellMarker Gene-Cell Type Associations	1.0	null
Acute myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.243
eGFP-GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_proteinGroups-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210580_5_v_6_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A-CA-04-2009(H1N1)_36Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.41217
SCH	GDSC Cell Line Gene Expression Profiles	1.0	2.45268
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.33811
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.97044
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE229468,GSE229471_0_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7648632__F1	PFOCR Pathway Figure Associations 2024	1.0	null
VANGL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17944
GSE62843,GSE64371_2_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE110178_5_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Tou	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.855
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.528
hematopoietic cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48975
extracellular space	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14488
Folic Acid	CTD Gene-Chemical Interactions	1.0	null
H3K4me3_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Helper T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.141
5732_NOL10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00926
GSE144115_4_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CEACAM16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00510725
Oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845704
GSE127916_1_v_0_nras_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE125157_1_v_0_piceatannol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.402
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LD-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CF-24-KQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219949
PC-87-OG75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.38103
6323_PIAS4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.505947
GSE209698_2_v_1_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE160304,GSE163392_0_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NPJ7-2826-SM-2I3FU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00141
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE255680_1_v_0_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A89237309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47281
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.407167
Blood plasma	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K60807536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03516
Schmidt-Lanterman incisure	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.861
CRCGN009_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16824
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25745
posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.840961
GTEX-XXEK-0008-SM-4BRW7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863864
17823238-TableS4a	GeneSigDB Published Gene Signatures	1.0	null
MCF7_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194169
K562_Disulfiram_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152514
MET_knockout_256_GSE25583	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.63047
H3K27ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SLC12A6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00494365
Plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-A56592690_PX12_PC3_6.0_h_30.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.53249
NCIH2029	CCLE Cell Line Gene CNV Profiles	1.0	1.3857
CRCGN016_MCF10A.TP53.M_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.19495
NR2F2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE215086_0_v_2_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
STAT5-23275557-MAMMARY-EPITHELIUM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC9069407__F3	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K95710843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10976
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Marvel domain	InterPro Predicted Protein Domain Annotations	1.0	null
lateral habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.91297
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.423353
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.17329
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X88G-0008-SM-47JWN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10359
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-4_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	1.0	3.12966
NCIH1694	CCLE Cell Line Gene CNV Profiles	-1.0	-2.04032
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.83052
PHB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00477888
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SIU7-0426-SM-2XCDX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39708
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
GSE165579_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K09378334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09508
Atazanavir (sulfate)_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0200526
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16484
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE144838_1_v_5_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
STAT3	ChEA Transcription Factor Targets	1.0	null
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.472
t61-colon_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.59067
CHRNA10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0862
Perturb_3217_KO_Stat1_SRP271755	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.51355
doxorubicin_homo sapiens_gpl550_gse1647	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
chr3_32496133_A_G_b38	GTEx eQTL 2025	1.0	3.8573
BRD-K85606544_neratinib_A549_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-5963-02A-12R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDT8-2926-SM-32PKC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01818
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
AC-31-PL89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244576
BRD-K73573019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29283
GTEX-S341-1726-SM-3K2AK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0488
GSE217115_2_v_0_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-14-QD12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.351119
BRD-K64418159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26539
Liver Diseases	CTD Gene-Disease Associations	1.0	1.86991
UF-14-LK87_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22048
NIHOVCAR3	CCLE Cell Line Gene Expression Profiles	1.0	1.48434
BRD-K97721960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.22421
MCF7_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133945
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Selisistat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142888
ChIP_STAT3_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Immune System Diseases	CTD Gene-Disease Associations	1.0	1.01137
hsa-miR-1910	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GSE232558_0_v_2_fbxl12_human	RummaGEO Gene Perturbation Signatures	1.0	null
JUN	JASPAR Predicted Transcription Factor Targets	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.842207
hsa-miR-4685-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0719
FADD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00373527
GSE96641_1_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.09595
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Edinger-Westphal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.833588
lower (caudal) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12535
Renal Insufficiency	CTD Gene-Disease Associations	1.0	1.06552
BRD-K87669982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50786
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bile duct carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
BRD-K01281780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80411
Intrahepatic cholangiocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51J-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_8991_KD_EGR2_SRP407074	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE136622_7_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146982_0_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4458	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
Hepatitis	CTD Gene-Disease Associations	1.0	1.79025
COLO741_SKIN	CCLE Cell Line Proteomics	1.0	6.65415
GTEX-S4UY-0006-SM-3K2A7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75248
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.51776
GATA3	ENCODE Transcription Factor Targets	1.0	null
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU-638	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A4BA-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ENAM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00518067
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Glioblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.584
PMC12956708-DataSheet1.xlsx-Supplementary_Table_7-Supplementary_Table_6_The_DEGs_from_high_altitude_between_AMS_and_non-eAMS_group_of_GSE75665_TWIST2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE122067_3_v_0_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
VSIG4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00620946
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE130676_0_v_2_suds3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K27294633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1074
BRD-K15794956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55566
BRD-K04853698_-666_SW620_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Poisoning	CTD Gene-Disease Associations	1.0	1.55157
SK-OV-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31134
bladder	GTEx Tissue Gene Expression Profiles	1.0	1.09783
BRD-K94580036_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K87657228_MLS-0425618_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Thyroid cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.893
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE246053_1_v_2_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4419b	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.90222
MZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5626
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A3WU-01B-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
IZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06661
SF-32-RC78_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229796
MCF7_Anacardic Acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0235642
STARD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00573601
hsa-miR-3183	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE210101,GSE210114_8_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.671349
GSE149035_2_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE104604_1_v_0_eif5a_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K55742134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8145
GTEX-TSE9-0011-R8A-SM-3DB7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39541
GSE154577_7_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_1_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NOP58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31948
HPAC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08833
Low Density Lipoprotein Cholesterol Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
outer CP in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17336
FLI1_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
LOVO	DepMap CRISPR Gene Dependency	1.0	3.26215
hippocampus (hippocampal formation)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.35671
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG7-2226-SM-3GIKP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03353
A549_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136173
Primary lysosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
8599_SUPT6H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.540348
PMC7617064-EMS151900-supplement-Extended_Data_Figure_7_Source_Data.xlsx-D23_RORC-Logfold_change_threshold_1_0_1_RORC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE218060_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7657020__F3	PFOCR Pathway Figure Associations 2024	1.0	null
KDM2B-26808549-CHIP-SEQ-REH-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.797
VIIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.826068
ZC3H11A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endocytic recycling	GO Biological Process Annotations 2023	1.0	null
GSE201309_4_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE209533_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2833-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K08219814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41815
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ERA-27197147-CHIP-SEQ-ENDOMETRIOID-ADENOCARCINOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K83751422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23516
MCF7_PD173074_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0287016
SETDB1	ENCODE Transcription Factor Targets	1.0	null
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.894656
SNUC1	DepMap CRISPR Gene Dependency	1.0	7.42169
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hippocampus (hippocampal formation)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00595
Perturb_32_OE_ERG/MYC_SRP069177	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.36768
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.457218
COPS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46037
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Pharynx cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.026
CF-50-QK79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.01627
GSE157555,GSE157556_5_v_6_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.15839
taxis	GO Biological Process Annotations 2015	1.0	null
GTEX-T2IS-2626-SM-32QPP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17725
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.524
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.364876
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE147834_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K50300854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17977
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K01976263_Emetine Dihydrochloride Hydrate (74)_LOVO_6.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GATA2-22383799-G1ME-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
POLE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00307026
digestive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
PDPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1459
TFAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1112
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.701197
BRD-K34851865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03388
CRCGN015_MCF10A.TP53.M_24H:O23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0129
Psoas_Muscle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.3068
Perturb_1564_KO_Tnfaip3_SRP056432	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.17797
GSE176008_7_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11627398-pone.0315219.s005.xlsx-MTF1-symbol_MTF1	Rummagene Transcription Factor Associations 2026	1.0	null
fulvestrant-985	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AA-11-RO46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265736
GTEX-RVPU-0011-R9A-SM-3NM8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.2946
BRD-K61431055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0591
hsa-miR-136	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GSE224547_1_v_0_cftr_human	RummaGEO Gene Perturbation Signatures	1.0	null
cytokine activity	GO Molecular Function Annotations 2015	1.0	null
Perturb_11675_KD_SKP1A_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.31896
cyclic-nucleotide phosphodiesterase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.685
GSE159148_0_v_1_sdc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169697,GSE169725_1_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U3ZG-0326-SM-47JXN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07411
JP-4-043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42662
GSE147943_4_v_6_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K53816426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0228
GSE101239_4_v_6_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
mRNA_JARID2_20075857	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
BRD-K54224946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56661
GTEX-P44H-0426-SM-2XCEZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03475
Lung adenocarcinoma_LUAD_TCGA-69-7761-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.906
mRNA_RAD21_21589869	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20046
BRD-K70161581_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
6550_POLR2I_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.697872
BRD-A18725729_2-[(chloroacetyl)(4-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE96641_5_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE139966_4_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3371315-NIHMS350140-supplement-13.xls-MCF7-T47D-SK-453_Up_Common_xls-Supplementary_Table_6_Luminal_Signature_Genes_increased_in_all_four_cell_lines_MCF7_T47D_MB-453_SKBR3_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K65135171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35563
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FLI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE135350_3_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
1840_CPSF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.568128
AE-64-KN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258931
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K81644801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20764
MMAA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.006193
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.04541
SMC3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G292CLONEA141B1	CCLE Cell Line Gene CNV Profiles	1.0	2.01254
DAOY_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	3.83024
icSARS CoV_0Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.20833
Movement Disorders	CTD Gene-Disease Associations	1.0	1.27286
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lung	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Perturb_5893_KD_CBX3_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.22276
BRD-K48912618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25271
PMC9013128-NIHMS1795992-supplement-4.xlsx-SKmel147_ARID2_KO_Upregulated-Gene_name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K16991828	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00446
KAT2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH2106	CCLE Cell Line Gene Expression Profiles	-1.0	-1.63504
3336_GEMIN5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.552397
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZFP281-27345836-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPL39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22443
CTCF	ENCODE Transcription Factor Targets	1.0	null
CRCGN011_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7755
GTEX-XPVG-0826-SM-4B654	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849931
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
16207381-Table1Sa	GeneSigDB Published Gene Signatures	1.0	null
SPI1	ENCODE Transcription Factor Targets	1.0	null
imatinib_homo sapiens_gpl96_gds3046	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A68427178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61488
Perturb_3927_KO_KMT2A_SRP277158	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
RXF393	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.887051
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.930173
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.75
GATA1_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14573_KO_EP300_SRP336466	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.295
FE-06-GR60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.303623
BRD-K06772291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19549
GTEX-PSDG-0426-SM-2S1OF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.995624
8230_SNRPD3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.505905
H4K20me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.837546
GSE236502_2_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XK95-0008-SM-4AT5G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19175
GTEX-RNOR-2226-SM-2TF5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.898779
hsa-miR-133b	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RTL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33251
Micronuclei, Chromosome-Defective	CTD Gene-Disease Associations	1.0	1.50877
GSE110178_1_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5894-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K78126613_MENADIONE_SKM1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A20B-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42475
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K83643280_BG FA 0953_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HW-A5KM-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLHL5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00527132
BRD-K99277076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44159
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUU-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100531_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.17378
BRD-A90289676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10484
Mafg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.2837
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K72713703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2732
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWSA-0126-SM-2XCBB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14135
GSE171401_1_v_0_adnp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Beta blocker survival benefit in heart failure with reduced ejection fraction (time to all cause mortality x beta blocker interaction)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.530103
CF-31-GE67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289158
B-lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.424
UE-90-AA63_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.305056
5427_NAA25_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.653336
BRD-K04928505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01315
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.882387
GSE157555,GSE157556_3_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-548e	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
vitamin c_homo sapiens_gpl570_gds3635	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE110178_4_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S95S-0008-SM-4AT5M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1846
CTCF_fibroblast of skin of abdomen_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
scy	GeneRIF Biological Term Annotations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5761-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LAMTOR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41067
BRD-K43729445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20655
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.8202
members	GeneRIF Biological Term Annotations	1.0	null
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-5631-01A-01R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cyclin D1-CDK4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.576
Lytic vacuole membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.9524
POLR2A_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE247862,GSE247863_0_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HT55	CCLE Cell Line Gene Expression Profiles	1.0	1.94142
SNB19	CCLE Cell Line Gene CNV Profiles	1.0	1.33435
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
WB-82-EL69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.499553
OV7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.55147
BRD-K40112492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04282
NECTIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18968
RSL1D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17219
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.38275
PRKD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00444539
GSE134700_0_v_4_ythdf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH1694	CCLE Cell Line Gene Expression Profiles	-1.0	-2.07162
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-A5G1-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RFX5	ENCODE Transcription Factor Targets	1.0	null
ASH2L	ChEA Transcription Factor Targets	1.0	null
Anorexia	CTD Gene-Disease Associations	1.0	1.04978
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.912875
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE143643,GSE143644_1_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE134375_6_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PL4	DepMap CRISPR Gene Dependency	1.0	2.0251
BRD-K40876208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4947
hippocampus (hippocampal formation)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.16398
BRD-K76487707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32623
A549_G007-LK_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160326
FOXA1	ENCODE Transcription Factor Targets	1.0	null
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.907177
16651409-SuppTable5	GeneSigDB Published Gene Signatures	1.0	null
AB-30-CR11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.329806
GSE172016_2_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K98320707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18303
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LA-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JD-10-HW02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208112
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.919074
GSE144443_10_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K83336168_-666_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K97395479	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30635
FLI1_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.50616
GTEX-S4P3-1626-SM-3K2AZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55376
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QK-01B-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4699-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17376_KD_E2f1_SRP190223	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.01922
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210682_0_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE109530,GSE109531_1_v_3_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MOLT-16	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.99875
GSE80098,GSE80366_0_v_5_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OIZI-0008-SM-2XCFD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7874
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
NCIH2171	CCLE Cell Line Gene Expression Profiles	-1.0	-1.72592
GSE143743_0_v_2_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HL60	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.989602
Fostamatinib (disodium hexahydrate)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0165193
19408105-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
external granular (germinal) layer of upper rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23349
BRD-K76068355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06503
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
decitabine_homo sapiens_gpl570_gse30985	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE226316_0_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TUBA4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00539956
GSE137144_5_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199204,GSE211619_4_v_2_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Intermediate filament cytoskeleton	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.486
PDHK1	Kinase Library Tyrosine Kinome Atlas	1.0	97.26
intermediate filament cytoskeleton	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE207787_1_v_4_pdha1_human	RummaGEO Gene Perturbation Signatures	1.0	null
central gray of the pons, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.33871
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL3G-0008-SM-4E3JX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852052
PMC9746818-jciinsight-7-152886-s077.pdf-22-ZNF615_ZNF615	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.56719
CRCGN015_MCF10A.TP53.M_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2149
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13452
GSE137144_2_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
1699_CMTM6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-1.10964
CAL-85-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.902537
GTEX-RU72-0008-SM-46MV8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.893068
Vdr	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.343
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
F12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00561321
5762_NPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.808108
Lung Injury	CTD Gene-Disease Associations	1.0	1.0204
megakaryoblast	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
JAR	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.89535
BRD-K14645917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23536
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE171292_5_v_2_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
specific granule	GO Cellular Component Annotations 2023	1.0	null
female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.15
8426_SRRT_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.509113
A549_AZ 960_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0114092
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189786
BRD-K39859838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75639
GSE236815_1_v_0_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-R53T-1826-SM-3GIJX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36728
GTEX-PVOW-2726-SM-48TCA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13491
GSE232631_5_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CORL47	CCLE Cell Line Gene Expression Profiles	-1.0	-1.88332
lysosomal membrane	GO Cellular Component Annotations 2023	1.0	null
PKCTHETA-26484144-CHIP-SEQ-BREAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.45943
Perturb_9176_KD_EZH2_SRP061380	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-19.699
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH2452	CCLE Cell Line Gene CNV Profiles	1.0	2.35372
GSE184892_6_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_38_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
6043_PAK1IP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.612686
schizophrenia	GWASdb SNP-Phenotype Associations	1.0	0.749042
recycling endosome	GO Cellular Component Annotations 2023	1.0	null
GSE128844_0_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYBL2-22936984-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0182
MYBL2-22936984-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NCIH446	CCLE Cell Line Gene Expression Profiles	-1.0	-1.85183
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nitrogen compound transport	GO Biological Process Annotations 2023	1.0	null
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.352623
Talc_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0113467
GSE198434_1_v_0_aspirin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE188382_4_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.983956
GSE210476_9_v_4_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WWYW-3126-SM-3NB39	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.884042
GSE217378_2_v_0_lin28b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
6274_PHAX_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.851001
CRCGN015_MCF10A.TP53.M_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36335
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H2BK12ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MD-86-UW46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.345756
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE183251_1_v_5_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.35177
FLI1_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN011_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1167
imatinib_homo sapiens_gpl96_gds3042	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PTPRCAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33445
GTEX-UTHO-0008-SM-4JBID	GTEx Tissue Sample Gene Expression Profiles	1.0	1.006
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE138672_0_v_1_rabgef1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA2_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K88328128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48985
primary somatosensory cortex (area S1, areas 3,1,2)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05449
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1381
GSE139239_3_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-Kasumi-1-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_Kasumi-1_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K48922193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.39111
outer portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1619
GSE225869_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
POU2F2	ENCODE Transcription Factor Targets	1.0	null
HT1080	BioGPS Cell Line Gene Expression Profiles	1.0	0.867707
HCC38	CCLE Cell Line Gene CNV Profiles	1.0	1.4168
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.444792
GSE232631_5_v_2_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IGR-37	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.995681
MXI1	ENCODE Transcription Factor Targets	1.0	null
early endosome	GO Cellular Component Annotations 2025	1.0	null
Perturb_6497_KD_PIEZO1_SRP392492	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02006
Bladder Urothelial Carcinoma_BLCA_TCGA-R3-A69X-01A-22R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
testis	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE241701_2_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PE01	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.994478
CRCGN015_MCF10A_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.8906
GTEX-OHPM-1626-SM-2HMK4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60721
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2A0-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158182_4_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver Failure, Acute	CTD Gene-Disease Associations	1.0	1.23743
RH-18	GDSC Cell Line Gene Expression Profiles	-1.0	-1.58951
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.438914
GSE203308_7_v_5_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2549_EIF3E_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.78484
GSE200352_9_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K60080002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07861
TNNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09518
Perturb_1658_KO_Gpr174_SRP365825	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.58387
GTEX-P4QS-0008-SM-48TDY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.908834
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.31826
A549_PCI-34051_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149715
pontobulbar body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23706
BRD-K28216304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12368
CREB1	ENCODE Transcription Factor Targets	1.0	null
epididymis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.491009
GSE164874_5_v_3_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE192689_0_v_3_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RPMI 2650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.928788
GSE211866_2_v_1_usp11_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC2694838-1471-2164-10-241-S2.xls-Sheet1-Regulated_genes_by_ZNF191_knockdown_ZNF24	Rummagene Transcription Factor Associations 2026	1.0	null
20460173-ImmPortComprehensiveListofImmune-RelatedGenes	GeneSigDB Published Gene Signatures	1.0	null
DC-98-HC94_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208041
hela	HPA Cell Line Gene Expression Profiles	-1.0	-1.47933
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.830157
BRD-K39979888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08186
8653_TAF12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.614845
SG in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.945767
BRD-K73982490_B3063_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE201217_4_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178340_5_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE84148,GSE96938_3_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X261-0326-SM-3NMD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48293
GTEX-RU1J-0008-SM-46MV9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3632
Compact myelin	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.624
STARD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56258
layer IIIu of area 35r	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.31422
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-2053	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
caco2	HPA Cell Line Gene Expression Profiles	-1.0	-0.84406
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.862873
A549_Regorafenib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138215
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67352
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K79932545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29765
Adrenocortical carcinoma_ACC_TCGA-OR-A5J8-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4051
ELF1	ENCODE Transcription Factor Targets	1.0	null
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13695
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fever	CTD Gene-Disease Associations	1.0	1.54281
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SBC-1	GDSC Cell Line Gene Expression Profiles	-1.0	-2.94936
fallopiantube_8e	HPA Tissue Sample Gene Expression Profiles	1.0	2.54489
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.799
BCL3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PDPN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00553975
GSE254517_3_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CDK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00475298
posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09254
TP63	ChEA Transcription Factor Targets	1.0	null
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Secretory vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE84148,GSE96938_0_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HGC27	CCLE Cell Line Gene Expression Profiles	-1.0	-1.51668
3504_GPN3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.542719
SNU-1040	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.696
deep layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03639
lateral ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04448
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
cdna	GeneRIF Biological Term Annotations	1.0	null
BRD-K44193634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16939
BRD-K24681473_S1130_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93477
SOX2-27498859-CHIP-SEQ-STOMACH-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYD88	MSigDB Cancer Gene Co-expression Modules	1.0	null
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FPR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00559067
Infertility, Male	CTD Gene-Disease Associations	1.0	1.15492
CTCF_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
extracellular vesicular exosome	GO Cellular Component Annotations 2015	1.0	null
STAT5A	ENCODE Transcription Factor Targets	1.0	null
GSE200352_4_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152937_6_v_5_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE144115_1_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JC-0626-SM-3NMA6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25547
MCF7_Obatoclax Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125496
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.306418
BRD-A54236247_RACEPHEDRINE HYDROCHLORIDE_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE171175,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_276_KD_USP13_SRP343502	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.4363
Shu complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.674
GTEX-WL46-0011-R11A-SM-3MJFT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870341
D341MED	CCLE Cell Line Gene Expression Profiles	-1.0	-1.66194
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-NEUN_UNIQUE_DYS_GENES-PAX6_TLE_vs_TL_log2FoldChange_1_padj_0_1_PAX6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A54347351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44391
GSE242290_1_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K80348542_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
estradiol_homo sapiens_gpl96_gds2324	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TCF7L2_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBX8	ENCODE Transcription Factor Targets	1.0	null
GTEX-WYJK-1726-SM-3NM9U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.9142
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K14780713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18643
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
7478_RPL7L1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.520644
GSE208350_4_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ECE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00531691
BRD-K82683018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26319
HCC3153	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.06386
WB-82-EL69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.441351
GTEX-SNMC-1426-SM-2XCFM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03266
GSE246335_4_v_5_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE188869,GSE188871_2_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PX3G-0008-SM-48U2L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0996
GSE199899_3_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.668719
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-2_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-W5X1-0008-SM-4LMKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12813
GTEX-RM2N-1926-SM-48FCU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828792
TXN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00573687
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226802
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	1.0	2.18649
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN009_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1404
Perturb_11348_KD_NFAT1_SRP173011	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.60622
BRD-K40958081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21148
PC-87-OG75_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.481043
Nephritis, Interstitial	CTD Gene-Disease Associations	1.0	1.21011
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4945_MED22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.583393
Ovary epithelial cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_4854_KD_ZEB2_SRP059197	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.92465
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.927777
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
2120_DDX41_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.558474
GTEX-QESD-0008-SM-447B2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.936086
GSE152441,GSE152442_0_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.25461
PMAIP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00395849
bewo	HPA Cell Line Gene Expression Profiles	1.0	2.70434
DE-03-NP53_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260781
H3K4me1_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE172490_5_v_3_junb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100585_PCx_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.4978
Glycine cleavage complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.238
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.22256
CTCF_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE203308_14_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140607_0_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8424797__F3	PFOCR Pathway Figure Associations 2024	1.0	null
4972_MEMO1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.676369
MCF7_CUDC-907_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00847036
GSE226091,GSE226092_0_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GE-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9359082__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I6-01A-12R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE249544,GSE249637_6_v_2_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XQ3S-0626-SM-4BOOB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32841
16643655-1300GenesList	GeneSigDB Published Gene Signatures	1.0	null
CTCF_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPN-0011-R1A-SM-2I5GB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69797
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4799-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.44641
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880917
cerebellum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.838485
Interstitial cell of Cajal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.804
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A13J-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.31153
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.971578
Stat2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	100.92
Prostate adenocarcinoma_PRAD_TCGA-CH-5769-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
BRD-K19755525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48369
LY2	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.00664
GSE180200,GSE180201_5_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PK-45P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.962948
BRD-K20470077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8179
NC-52-AG88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.493946
BRD-K97839095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1691
HUP-T3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.908464
GTEX-WFG7-0008-SM-4LMKB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05008
16909099-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
GTEX-S341-0008-SM-4AD6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56805
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09593
BRD-K56653679_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09367
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GRIK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00679364
GSE196117_6_v_11_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K67578145_GDC-0879_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SFPI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
STAT6	MSigDB Cancer Gene Co-expression Modules	1.0	null
GSE160817_5_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11093744-41592_2024_2172_MOESM3_ESM.xlsx-ELP-genes_NR5A1	Rummagene Transcription Factor Associations 2026	1.0	null
Depressive Disorder	CTD Gene-Disease Associations	1.0	1.31536
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_10891_OE_Trim24_SRP355273	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.24008
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4T-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.38602
Pancreatic adenocarcinoma_PAAD_TCGA-F2-6879-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCV JFH1_168Hour-Huh7_None_GSE29889	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.8226
GTEX-W5WG-1926-SM-4KKZK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04707
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31134
GSE218580_1_v_3_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CPC-N	GDSC Cell Line Gene Expression Profiles	-1.0	-2.085
BRD-K21075720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02224
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BORCS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68861
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.50808
Rectum adenocarcinoma_READ_TCGA-G5-6641-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WK11-2526-SM-3NM9Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14721
CL34	CCLE Cell Line Gene Expression Profiles	1.0	1.37438
TC-71	COSMIC Cell Line Gene Mutation Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03491
IL15RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00462501
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054794
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.453281
RVH421_SKIN	CCLE Cell Line Proteomics	1.0	3.26911
Biliary tract cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.278
Renal cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.104
JHOS2	CCLE Cell Line Gene CNV Profiles	1.0	1.76481
GTEX-WYVS-2326-SM-3NMAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37689
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039253
SPI1-26923725-CHIP-SEQ-HPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_12850_KO_Tet2_SRP338315	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.20934
ZNF24_01_353	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.63255
Perturb_12667_OE_MX2_SRP308919	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.4953
GTEX-TKQ1-0008-SM-4DXSO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04754
striatum_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.926223
hsa-miR-4269	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Up_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K70940767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20457
Oral cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.99
GTEX-VJYA-0126-SM-4KL1P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901187
TXNL4B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00412528
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	1.0	null
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.513
Urinary bladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.424
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ETS1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
znf217_22593193_mda_mb_231_gof_human_gpl570_gse35511	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.059225
GATA1_G1E-ER4_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ES-I3 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.937898
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
A549_GSK-LSD1 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154951
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050952
GSE213048_1_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NB6	GDSC Cell Line Gene Expression Profiles	-1.0	-2.45749
Ahr::Arnt	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.5
GTEX-XOTO-0011-R6B-SM-4B65X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03416
cklf2	GeneRIF Biological Term Annotations	1.0	null
A549_Zileuton_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159917
GSE180200,GSE180201_15_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE132369,GSE132371_3_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
DPH7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11387
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.23666
TB-06-VB30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.369111
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67309
BRD-K79090631_CGP-60474_HA1E_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE160246_9_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.682673
Oral cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.79
VZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.943618
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PECAM1	MSigDB Cancer Gene Co-expression Modules	1.0	null
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K06593056_LE 135_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.685592
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RAD21_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215582
K562_UNC0631_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156837
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904881
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.13703
GSE125862_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A67552019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47083
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146982_0_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A41451487_PK-11195_A375_24.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CMTM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73377
RAD21	ENCODE Transcription Factor Targets	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8432-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HUP-T4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.919074
Vacuole	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
H3K79me2_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE120413,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_3010_KD_PAX2_SRP119912	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.15659
BRD-K72694472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66595
GTEX-VUSG-0008-SM-4KL24	GTEx Tissue Sample Gene Expression Profiles	1.0	0.911988
CRCGN013_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.36341
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980274
Nevirapine_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0206797
anterior (rostral) cingulate (medial prefrontal) cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.843593
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.384371
SFPI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CRCGN009_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.06177
BRD-K32595757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43753
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
4951_MED28_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.670743
hsa-miR-4789-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.995927
esr2_15280152_c57bl6_mice_soleus_skeletal_muscle_lof_mouse_gpl81_gds791	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.768114
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Nausea	CTD Gene-Disease Associations	1.0	1.08442
GTEX-TSE9-0011-R9A-SM-3DB7Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16247
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
organelle	GO Cellular Component Annotations 2015	1.0	null
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.056
TRMT13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12321
CRCGN015_MCF10A.TP53.M_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5523
Malignant ovarian surface epithelial-stromal neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
HCC33	CCLE Cell Line Gene Expression Profiles	-1.0	-1.78174
TUBA1C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00761478
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.943848
GSE140092_0_v_1_socs3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
1206_CASP8AP2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.533454
6517_POLD3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.613854
BRD-A95696820_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
17660535-TableS4c	GeneSigDB Published Gene Signatures	1.0	null
DND-41	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.69
D283MED	CCLE Cell Line Gene Expression Profiles	-1.0	-1.71752
GA-23-VF89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214569
Acute Myeloid Leukemia_LAML_TCGA-AB-2867-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R45C-0926-SM-3GAD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.6
MOLM16_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.88363
BE-82-TS38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265689
GSE98898_4_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-N7MS-0011-R1a-SM-2HMJG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03937
GSE101336_1_v_0_decitabine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MHH-NB-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.2719
BRD-K13279882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28002
GTEX-V955-2426-SM-3GAEF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892818
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159143
GTEX-N7MS-0008-SM-4E3JI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17592
BxPC-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.354
BRD-K25540102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28866
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EW-18	GDSC Cell Line Gene Expression Profiles	-1.0	-1.67469
BRD-K92317137_-666_HT115_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
skeletal muscle	HPA Tissue Protein Expression Profiles	-1.0	-0.816233
ARPC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00398058
Fallopian Tube	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.27925
GTEX-O5YV-2026-SM-2D7VS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02745
MCF7_Veliparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184028
Proteinuria	CTD Gene-Disease Associations	1.0	1.35184
Massive Hepatic Necrosis	CTD Gene-Disease Associations	1.0	1.30329
K562_Motesanib Diphosphate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198045
BRD-K78867378_mw-A1-12_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-P4PQ-1626-SM-2HMKK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10048
GSE178113,GSE178116_0_v_1_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
E2F4	ENCODE Transcription Factor Targets	1.0	null
Perturb_15521_OE_proL1_SRP277452	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.4996
GF-32-FY02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201713
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.42635
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	1.0	3.34644
LS513	CCLE Cell Line Gene Expression Profiles	1.0	1.62208
Lung adenocarcinoma_LUAD_TCGA-05-4403-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K93677460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09318
Azurophil granule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Apolipoprotein B levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.75229
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.66671
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.969765
GTEX-RVPU-0011-R1A-SM-2XCAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.56493
GB-45-YG91_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232784
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11261
EGR1-23403033-LIVER-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
ARID3A	ENCODE Transcription Factor Targets	1.0	null
RIPK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00545149
Perturb_7784_KD_BS692_SRP030639	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE138019_3_v_2_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.192
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-10_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.08157
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.3103
PMC7062471-elife-52504-supp6.xlsx-TEAD4_motif_in_OCR_around_DEGs-Gene_ID_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
SIRT6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K14ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K66179451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41148
MYC-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Microglial cell_Embryonic prefrontal cortex_Human	CellMarker Gene-Cell Type Associations	1.0	null
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0884
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.54989
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03344897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.57338
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.84628
GTEX-WWYW-0011-R11A-SM-3NB38	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998876
KLF5-20875108-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
lysosomal membrane	GO Cellular Component Annotations 2025	1.0	null
BRD-K56616847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73985
hsa-miR-133a	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4942_MED1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.699849
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36955
hematopoietic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
K562_Abexinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156395
UBTF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.88662
prostate gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-A93942655_NCGC00188535-01_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GABPA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K99633092_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RHOC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10158
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12736
Irf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	57.6768
blood	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE48812_2_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_13585_KD_Tardbp_SRP314028	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.41952
GSE154350_1_v_0_ascl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K85044233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20667
GTEX-TSE9-0008-SM-4DXT8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15423
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.939
GSE132369,GSE132371_4_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A64374397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82242
GSE135030_3_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-3922-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
BRD-K97339945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69569
K562_Divalproex Sodium_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167262
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.925853
GSE178714_6_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.42
Arnt	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.45
PPBP	Pathway Commons Protein-Protein Interactions	1.0	null
NTRK3_drugactivation_67_GSE20358	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	3.42693
GTEX-XPVG-2526-SM-4B66D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4365
wt1_00000000_mouse_embryonic_fibroblast_mef_lof_mouse_gpl1261_gse15325	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.082736
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4505
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.86497
GTEX-N7MT-0007-SM-3GACQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878993
HEP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.25146
GSE198165,GSE198166_6_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Adrenal cortex cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
Perturb_17562_KD_IRAK2_SRP396814	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.47112
IFNA10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00395744
ACTA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00682877
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A110-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
HE-43-BS90_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240077
Anemia, Hemolytic	CTD Gene-Disease Associations	1.0	1.23993
Ovarian Neoplasms	CTD Gene-Disease Associations	1.0	1.03604
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mania	GWASdb SNP-Phenotype Associations	1.0	0.445424
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K47170544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38422
GSE134375_4_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CW-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.808
early endosome membrane	GO Cellular Component Annotations 2023	1.0	null
STAT3	ENCODE Transcription Factor Targets	1.0	null
megakaryocyte	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Glottis squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
NCI-H2126	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.927822
GSE190555,GSE190557_2_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MS-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.933
GSE105169,GSE105175_0_v_1_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE190177_1_v_0_sgpl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ONECUT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9003
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.636
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.56699
PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-ZBTB7B_mod_ZBTB7B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CAL120	CCLE Cell Line Gene CNV Profiles	-1.0	-1.61557
Oleanolic Acid	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.58
GSE139455_2_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242199_6_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
5430_NAA38_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.839961
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0658
cytoplasmic part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
LCAM1	DepMap CRISPR Gene Dependency	1.0	2.06353
GSE137914_0_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XLM4-2926-SM-4AT59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.846771
WHSC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCFAP2C-20176728-TROPHOBLAST STEM CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
receptor binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.39056
TP53	ChEA Transcription Factor Targets	1.0	null
Pancreatic ductal adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.773
hsa-miR-4476	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YE-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NIHOVCAR3	CCLE Cell Line Gene CNV Profiles	1.0	1.71616
Lung adenocarcinoma_LUAD_TCGA-97-7552-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
orbital frontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.45275
HDAC2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
8233_SNRPG_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.61807
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881939
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239746
GTEX-U3ZM-1226-SM-3DB9G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955332
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00187
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247677
orbital frontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.22097
ITGB2	MSigDB Cancer Gene Co-expression Modules	1.0	null
VANGL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00630804
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.402
hsa-miR-340	TargetScan Predicted Conserved microRNA Targets	1.0	0.336728
A549_Tofacitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129507
GSE203362_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S32W-2126-SM-2XCB1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97361
16489042-SuppTable1b	GeneSigDB Published Gene Signatures	1.0	null
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE129244_0_v_5_lmo2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193282_3_v_1_cd44_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
COP9 signalosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.749
striatum_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.898136
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.38848
UF-14-LK87_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.501283
TCF3	ENCODE Transcription Factor Targets	1.0	null
PANC-08-13	GDSC Cell Line Gene Expression Profiles	1.0	1.42841
BRD-K39639513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49135
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXO3-22982991-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K15380626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93423
Lung squamous cell carcinoma_LUSC_TCGA-60-2703-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE176008_7_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K94489736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.56765
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.06247
17724462-TableS1	GeneSigDB Published Gene Signatures	1.0	null
BRD-K78867378_mw-A1-12_SKM1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE216043_11_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
1206_CASP8AP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.523559
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.32005
primary motor cortex (area M1, area 4)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20066
GSE93309_1_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5J2-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PRKAG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00347394
Sarcoma_SARC_TCGA-SI-A71Q-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE221327_10_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TKQ2-0008-SM-4DM5L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.936254
GTEX-XUW1-0008-SM-4BOQH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46229
KLF4-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Hypertrophy	CTD Gene-Disease Associations	1.0	1.48556
SYNCRIP_OE_GDS1806_82_human_T-lymphocytes from normal donors were activated with anti-CD3 and IL2	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
probucol_mus musculus_gpl9526_gds3619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-SUCS-0008-SM-4DM53	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983971
KAP1-27257070-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
EZH2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE234647_1_v_3_regorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE103068_0_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE192689_0_v_1_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC1395	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.757676
GSE120413,GSE120447_0_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HEP-3B cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.187
GSE152379_0_v_4_bach2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
8651_TAF10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.694589
5762_NPAT_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.695968
Brain Lower Grade Glioma_LGG_TCGA-HT-7882-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_16430_KD_Tead1_SRP327850	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
HT-1080	GDSC Cell Line Gene Expression Profiles	1.0	1.50073
15735024-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.898572
496100340_TCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.56858
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAFK	ENCODE Transcription Factor Targets	1.0	null
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4642-01B-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178340_7_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Talc_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0220786
GSE154197_1_v_2_ints13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MTA3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00459518
3054_FECH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.582284
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4282	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_Myeloid-Unnamed_1_RAG1	Rummagene Transcription Factor Associations 2026	1.0	null
uterus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
HCC1143	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.23239
2918_FAM32A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.50431
CRCGN017_MCF10A.TP53.M_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.05141
Liver Cirrhosis	CTD Gene-Disease Associations	1.0	1.35328
Paranode region of axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.514
myeloid progenitor cell	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.572872
SIX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7836
REST_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EFHD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00483308
anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0551
Perturb_1650_KO_Tnfaip3_SRP056432	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.63287
GSE161771_0_v_1_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7883
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRL-0326-SM-2I3F2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965893
Confusion	CTD Gene-Disease Associations	1.0	1.06225
ZNF148_01_73	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.74924
Kidney cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.68
Endosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	3.25702
BRD-K36168475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89703
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LT-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPB_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73692505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45249
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.43327
GSE154577_13_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K01976263_Emetine Dihydrochloride Hydrate (74)_HCC515_24.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14581
Erythroleukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NFATC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00383978
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.722468
MCF7_Hesperadin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152947
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03015
GSE225647_1_v_3_srsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH209	CCLE Cell Line Gene CNV Profiles	-1.0	-1.76478
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CEBPD_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE87412,GSE92423_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HS 852.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07543
LYPLA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42596
BRD-K88613983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93125
GSE231524,GSE231526_0_v_1_dusp6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN012_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00465
NCIH838_LUNG	CCLE Cell Line Proteomics	1.0	2.85362
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lysosomal membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
8126_SLU7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.717316
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
20081105-ST-2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-U3ZH-1926-SM-4DXTR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.939179
GTEX-PX3G-1626-SM-2S1PT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.962639
BRD-K71755682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11671
GSE84148,GSE96938_0_v_2_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GXYLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12398
CAL33	CCLE Cell Line Gene CNV Profiles	-1.0	-1.93392
WB-82-EL69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.279708
PMC9208818__F3	PFOCR Pathway Figure Associations 2024	1.0	null
AD-52-UZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203276
Esophageal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.293
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200433
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCILY19	DepMap CRISPR Gene Dependency	1.0	2.3253
PMC6606599-41598_2019_45777_MOESM14_ESM.xlsx-SAVA_DE_genes_promoter_DMRs-Unnamed_22_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE166317_2_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
E2F6	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4354-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39793
MAFF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A11702965_230752_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_16429_KD_Tead1_SRP327850	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P44H-0008-SM-48TDW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23489
19204204-SupplementaryTable5	GeneSigDB Published Gene Signatures	1.0	null
Perturb_3420_KO_USP7_SRP330182	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2412
GTEX-SNOS-1526-SM-32PLW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923089
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04269
BRD-K47883435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2155
RER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84827
SRF_KO_GDS3732_148_mouse_HSC	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE189941_1_v_0_kdm4c_human	RummaGEO Gene Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.911897
outer CP in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.85793
GSE140997_4_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.80652
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.586
gata1_15860665_megakaryocytes_lof_mouse_gpl1261_gds1245	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.184832
GSE94011_0_v_3_pias3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q8-01A-31R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CSKMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13046
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.71214
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE242049_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H4K20me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K82685933_BTB06091SC_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cyclophosphamide_mus musculus_gpl13209_gse27440	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
rt4	HPA Cell Line Gene Expression Profiles	1.0	1.01933
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.177
RBBP5	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7432-11A-01R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K82164249_S1140_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NY	GDSC Cell Line Gene Expression Profiles	1.0	1.55972
Perturb_1549_KO_Rpl23a_SRP056432	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.68569
ACKR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00521375
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE89767_2_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WNT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00664442
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.67723
GSE211983_0_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SKMEL24	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34145
GSE102132_2_v_1_irf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Vacuolar membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
DA-17-YW85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.287539
CRCGN015_MCF10A.TP53.M_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0454
BRD-K78873216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33656
BRD-K88573743_A443654_HCC515_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Uterus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-OOBJ-0008-SM-3NB26	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982156
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.26275
Epilepsy, Tonic-Clonic	CTD Gene-Disease Associations	1.0	1.12357
artery disease	GWASdb SNP-Disease Associations	1.0	0.378691
BRD-A09719808_NCGC00188536-01_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE171572_3_v_4_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Recycling endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.234
MHHES1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.61344
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cholesterol, total	GWAS Catalog SNP-Phenotype Associations	1.0	0.405958
Brain Lower Grade Glioma_LGG_TCGA-HT-8563-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE169205_3_v_8_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Huntington's Disease_CNS - Brain - Striatum (MMHCC)_GSE5786	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.55443
BRD-K42716291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81124
CRCGN016_MCF10A.WT.HP_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.2165
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
erg_19359602_huvec_lof_human_gpl570_gds3557	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.117945
496100622_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.58238
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.69231
BRD-K05104363_HY-50295_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Glioma	DisGeNET Gene-Disease Associations	1.0	null
DD-74-PJ26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.443055
VMRCLCD	CCLE Cell Line Gene CNV Profiles	-1.0	-1.66442
USF2	ENCODE Transcription Factor Targets	1.0	null
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	1.0	2.01293
BRD-K81515704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13691
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
outer CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04144
GSE166783_8_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.13269
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.07399
GSE143643,GSE143644_3_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hippocampus (hippocampal formation)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.27218
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.46657
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K39176069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29071
CTCF_GM12873_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K15409150_penfluridol_VCAP_6.0_h_30.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SOX2	ChEA Transcription Factor Targets	1.0	null
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
clusters	GeneRIF Biological Term Annotations	1.0	null
hsa-let-7i	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
MCF7_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014294
GD-07-HO70_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.383012
4957_MED7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.78785
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4146-01B-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZN-2226-SM-3DB88	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934495
BB-62-MS83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274626
Uterine endometrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SNU387	CCLE Cell Line Gene CNV Profiles	1.0	2.43767
GTEX-V1D1-0526-SM-4JBGW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.999998
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K77547509_3-cyclohexyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE200352_1_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1	ENCODE Transcription Factor Targets	1.0	null
GABPA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.987
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70J-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gonad	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.225395
GSE143212_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.840053
inner CP in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.844178
GSE111385_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me1_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	1.0	2.42568
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03457
Ataxia	CTD Gene-Disease Associations	1.0	1.01776
A549_Abexinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0103124
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.07887
GTEX-XMK1-0008-SM-4GICF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901513
intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
JA-95-PQ25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250818
EGR1	ChEA Transcription Factor Targets	1.0	null
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HGC-27	GDSC Cell Line Gene Expression Profiles	-1.0	-1.47335
GSE180200,GSE180201_5_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TC138	DepMap CRISPR Gene Dependency	1.0	3.88071
posteroventral (inferior) parietal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.928827
GSE136622_2_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Atherosclerosis_Hepatic Tissue_GSE363	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.32785
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-0011-R6A-SM-3DB7L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847865
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1143	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.08204
TMBIM4	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3410-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI H322M	BioGPS Cell Line Gene Expression Profiles	1.0	1.76076
CTCF_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE205316,GSE205317_0_v_1_nrip1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CLC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.005714
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.51776
PMC10185556-41467_2023_38439_MOESM3_ESM.xlsx-ST19_MR_results-nearest_gene_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X4EO-0526-SM-3P5Z3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.96677
SVIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87933
BRD-K60531990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9332
BRD-A04706586_Dibutyryl-cAMP, sodium salt_COV644_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE133927_1_v_0_meox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ONCODG1	CCLE Cell Line Gene Expression Profiles	1.0	2.11378
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Heart Diseases	CTD Gene-Disease Associations	1.0	1.74159
Embryo Loss	CTD Gene-Disease Associations	1.0	1.20881
GSE142684_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE188870,GSE188871_4_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSU	CCLE Cell Line Gene CNV Profiles	1.0	2.03842
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MESD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04605
GTEX-PVOW-0008-SM-48TE8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04789
hsa-miR-3147	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Uterine body mixed cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.358
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.14823
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSK3A_knockdown_201_GDS4305	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.44612
primary auditory cortex (core)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14309
Lung adenocarcinoma_LUAD_TCGA-97-7941-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Neutrophil degranulation	Reactome Pathways 2024	1.0	null
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRAPPC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04592
GSE220520_3_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TKQ2-0826-SM-33HB6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35191
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_CYC116_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138916
Kidney Chromophobe_KICH_TCGA-KN-8422-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CSTB_KO_GSE47516_678_mouse_mouse cerebellum at P30	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.919
Nr5a1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.551
POLR2A_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.085
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75275
amygdaloid complex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.73336
CAL51	DepMap CRISPR Gene Dependency	1.0	3.20266
hsa-miR-548z	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
BRD-K19502817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.35301
BRD-A75409952_wortmannin_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.305114
GTEX-R55F-1226-SM-2TF59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859996
JUN_01_164	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	9.54144
BRD-K85441584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.55344
GSE116930,GSE116935_3_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149264,GSE149267_4_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.45876
H3K27ac_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.645859
CRCGN011_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44565
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE130437_2_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ME-11-OJ38_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206413
Nkx2-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.8701
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.885186
Lung adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.691
MCF7_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0226391
GTEX-WL46-0926-SM-3LK7T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.893208
GSE209582_1_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9270251-mmc2.xlsx-2_Filtered_DEGs_Control_vs_KD_2-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-6672-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRKCZ_KO_GDS4310_293_mouse_heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K19507340_megestrol_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3CC-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T2IS-3026-SM-32QPM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897693
RELA_02_39	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61398
BRD-A17043706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22281
DUXA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4347
ONCODG1	CCLE Cell Line Gene CNV Profiles	1.0	1.65131
hippocampus (hippocampal formation)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.43195
MCF7_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167493
fallopiantube_8c	HPA Tissue Sample Gene Expression Profiles	1.0	2.08995
BRD-K09655230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12233
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.47564
superior frontal gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00689
FOXA2	ENCODE Transcription Factor Targets	1.0	null
BRD-K51087734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04247
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
M2 macrophage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.469
GSE225869_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CALU1	CCLE Cell Line Gene CNV Profiles	1.0	1.56072
CAPAN-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.53
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
early endosome	GO Cellular Component Annotations 2023	1.0	null
GSE113106_2_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE77108_5_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.034
locomotion	GO Biological Process Annotations 2015	1.0	null
GSE125219,GSE125221_5_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
amygdaloid complex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.929884
BE-07-XI66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202494
H3K4me3_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K30488928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25879
RSPH9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00463376
HCC1954	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.875035
GTEX-T5JC-0008-SM-4DM6A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08674
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.15763
BRD-K32944375_NCGC00184834-01_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SKNAS	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6184
H4K20me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Weight Gain	CTD Gene-Disease Associations	1.0	1.01966
GSE217873_1_v_0_nusap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:G17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.88755
GTEX-NPJ7-0008-SM-4E3JS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08305
GTEX-N7MS-0011-R2a-SM-2HML6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.96851
GSE217776,GSE217829_4_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K70357895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7081
MYC_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125007,GSE125008_6_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_INO-1001_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130275
K562_Pirarubicin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160753
GSE151612_4_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
TUBA3C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00505404
IRF8-27001747-CHIP-SEQ-BMDM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Hemorrhage	CTD Gene-Disease Associations	1.0	1.30208
NCIH28	CCLE Cell Line Gene CNV Profiles	1.0	1.51435
Lung adenocarcinoma_LUAD_TCGA-49-4510-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
4696_LSM6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.557748
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A119-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.986468
BRD-K78344913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14216
Perturb_6163_KO_Sh3gl1_SRP315284	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.56952
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_11_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.39311
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.32011
Perturb_8842_KD_ESRRA_SRP254908	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
hematopoietic stem cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE237040_6_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
2203_DHX15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.569515
1583_CHMP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.838756
BRD-K90686530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00873
ventrolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.35962
YBX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38378
KMS-28BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.839442
cyclophosphamide_mus musculus_gpl13209_gse27421	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S3XE-0008-SM-3NM8O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18004
GTEX-S4UY-0926-SM-4AD6O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.932885
Azurophil granule membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
CXXC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17286
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.330111
GSE93309_5_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EOL1	DepMap CRISPR Gene Dependency	1.0	3.36283
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.833583
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29263
BRD-K17040651	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27152
GSE115763_3_v_1_klf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE224294_4_v_2_ngly1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7220941-41598_2020_64431_MOESM2_ESM.xlsx-WS1_2019_Affy_IDs_RA-STvsOA-ST-Unnamed_2_PAX3	Rummagene Transcription Factor Associations 2026	1.0	null
FBXO21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04949
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J8-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAOV4	CCLE Cell Line Gene Expression Profiles	1.0	1.54047
Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6WZ-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-8138-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-557	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
BRD-K67689282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19088
Epithelium	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GATA1_G1E-ER4_mm9_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.982987
hsa-miR-378a-3p	MiRTarBase microRNA Targets	1.0	null
Pancreatic adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.536
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3JV-01A-11R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GSE171724_4_v_6_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20392
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4343-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CREB1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8106-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.06196
BRD-K75263760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6075
Rectum adenocarcinoma_READ_TCGA-AG-4021-01A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.294378
POLR2A_GM12891_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUV39H1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00459891
BRD-K88441035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78754
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.04932
GTEX-T6MN-0011-R5A-SM-32QPD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828695
GTEX-X638-0008-SM-47JZ7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26253
Perturb_7516_KO_TFAM_SRP213924	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.45469
A549_Momelotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.010657
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17009876-tableS1a	GeneSigDB Published Gene Signatures	1.0	null
PMC11076560-42003_2024_6230_MOESM5_ESM.pdf-49-NR1H3_NR1H3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K47314501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70802
Lung squamous cell carcinoma_LUSC_TCGA-37-3792-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
plasma membrane	LOCATE Curated Protein Localization Annotations	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16686
BRD-K78195641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.98439
K562_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012436
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVUS-0226-SM-3GIJY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73373
SB-80-CR34_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.315829
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-12_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
blood	GTEx Tissue Gene Expression Profiles	1.0	1.1981
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5259-01A-31R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2939
Liver hepatocellular carcinoma_LIHC_TCGA-ZP-A9CY-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
phagocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.0237
extracellular vesicle	GO Cellular Component Annotations 2015	1.0	null
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.268
GSE158834_1_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
2460_ECD_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.625491
GSE168604,GSE183859_1_v_0_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24006
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the level of lipoprotein cholesterol	GWASdb SNP-Phenotype Associations	1.0	1.24751
PK-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4553
CRCGN014_HEPG2_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37074
GTEX-UTHO-0011-R5A-SM-3GIJD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20687
BRD-K74701308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15266
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.98413
bipolar disorder	GWASdb SNP-Disease Associations	1.0	0.522174
NTRK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00495621
GSE48812_7_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5031867-mmc2.xlsx-RYTTCCTG_V_ETS2_B-GENE_SYMBOL_ETS2	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73479560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10839
Sarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
Renal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.675
GSE220520_3_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
XC-88-ZM66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218618
XRCC6	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K17850764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76691
2658_EP400_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.517424
UF-14-LK87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30398
MDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04107
NEIL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36602
GSE108084_3_v_2_epinephrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TP53-23651856-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CUX1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P78B-1626-SM-2S1O1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57835
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54748
QE-48-NG07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232043
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE227127_1_v_0_diclofenac_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Piperonyl Butoxide	CTD Gene-Chemical Interactions	1.0	null
GSE249098_3_v_2_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BCLAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K64449549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08468
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.60035
PMC10169359-13058_2023_1653_MOESM1_ESM.xlsx-Table_S9-Table_S9_Genes_differentially_expressed_between_TP53_mutant_and_wild-type_pBCs_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST	ENCODE Transcription Factor Targets	1.0	null
recycling endosome	GO Cellular Component Annotations 2025	1.0	null
GSE140997_4_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Calu-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.724
H3K27ac_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE216043_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q8-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K34169251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83752
NCIH69	CCLE Cell Line Gene Expression Profiles	-1.0	-2.72219
5904_NUP98_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.501048
Malignant astrocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.581
NE-00-JZ19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246567
BRD-K86472598_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN011_HEPG2_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4838
H3K9me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AD-51-SS86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.313009
EEF1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26535
Perturb_6862_KO_CDK19_SRP299261	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSK3A_knockdown_203_GDS4305	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.67607
GSE210580_0_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	1.0	2.22333
Cleft Palate	CTD Gene-Disease Associations	1.0	1.38946
BRD-K28907958_-666_SW948_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FA-06-GA39_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250225
GSE224969,GSE224971_0_v_7_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IKZF1	ENCODE Transcription Factor Targets	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.037
Brain Lower Grade Glioma_LGG_TCGA-HT-7478-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAL1	ChEA Transcription Factor Targets	1.0	null
GSE146982_7_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SARS-dORF6_84Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.51218
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4863-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K43834805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05045
Fetal_Brain_Female	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-2.45241
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-8501-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K38190084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05586
GSE183251_1_v_3_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Sarcoma_SARC_TCGA-QQ-A8VG-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZMIZ1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic ductal adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.316
GSE150215_1_v_2_etl4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Inflammation	CTD Gene-Disease Associations	1.0	1.99639
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
8332_SPC25_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.19386
AP1S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04001
hsa-miR-3929	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
POM121C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24513
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE236504,GSE236505_0_v_1_atmin_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-VJWN-0426-SM-3GIJI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2004
BRD-K95839423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08967
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157777_1_v_0_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4770-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1770	GDSC Cell Line Gene Expression Profiles	-1.0	-1.57517
MUM-2B cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.251
AA-67-TF79_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.366591
characterized	GeneRIF Biological Term Annotations	1.0	null
GSE48812_11_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00159
inferolateral temporal cortex (area TEv, area 20)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02595
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EW1	DepMap CRISPR Gene Dependency	1.0	2.98711
Perturb_341_KD_EGFP_SRP076553	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE224969,GSE224971_3_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17676974-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SQ-A6I4-11A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147666
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NFK9-0626-SM-2HMIV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89159
NCI-H2081	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.37428
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851769
CA2 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.2158
LDL cholesterol	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.8
PMC4860404-Table2.XLSX-MR_specific-Table_S2-9_DEG_specific_for_mouse_rat_SCI_at_3_dpi_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1329
BRD-A16760970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06712
CA2 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.63591
hsa-miR-3176	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
4935_MED14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.532085
NCI-H1395	GDSC Cell Line Gene Expression Profiles	-1.0	-1.80475
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.006
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A8BP-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate gland epithelium	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE166783_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
2852_FAM133B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.528788
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136721
GSE164463_2_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
G140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04832
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054876
NRL_Deficiency_GDS2936_629_mouse_Retinas - 2 days	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K69650333_idarubicin hcl_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13369
ZC3H3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73791
YY1	ENCODE Transcription Factor Targets	1.0	null
3246_GAB2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.546854
GSE221327_6_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QMR6-0008-SM-447AV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07951
BRD-K61726189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00401
Acute Myeloid Leukemia_LAML_TCGA-AB-2987-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
4593_LIN52_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.581125
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.92779
GSE203308_1_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179197
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.850473
CBX3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE102505_6_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KMS28BM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33341
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0011-R1A-SM-32QOY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.918159
17616640-TableS1	GeneSigDB Published Gene Signatures	1.0	null
HUH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11634
GSE146687_2_v_0_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X88G-0326-SM-47JZ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18112
Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-7130-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45601
BRD-K18190982_COT-10b_SKM1_6.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE216043_10_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.9267
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_induced_genes-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BT474	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
PMC7648632__F2	PFOCR Pathway Figure Associations 2023	1.0	null
Rectum adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.019
GSE161295_0_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-466	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE143790_0_v_1_bcl9_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.928434
HUP-T3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.840512
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD4	ENCODE Transcription Factor Targets	1.0	null
LYN	MSigDB Cancer Gene Co-expression Modules	1.0	null
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.994478
GSE158834_2_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
COLO849	CCLE Cell Line Gene CNV Profiles	1.0	1.59445
CPCN	CCLE Cell Line Gene CNV Profiles	-1.0	-1.61769
MCF7_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162293
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.58702
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-9_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
4940_MED18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.935586
FZD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56835
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QEG5-0426-SM-2I5GJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41372
Heart Defects, Congenital	CTD Gene-Disease Associations	1.0	1.35763
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.62061
BRD-K22863062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49426
GTEX-T6MN-2526-SM-32PMN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04863
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.66033
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.78751
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00185
Bonemarrow	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.978079
Tumor necrosis factor receptor superfamily complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.845
Micrognathism	CTD Gene-Disease Associations	1.0	1.03827
GSE210101,GSE210114_6_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.1592
CA1 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.26293
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834896
GSE168401_2_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Heart Failure	CTD Gene-Disease Associations	1.0	1.14885
PPID	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12198
orbital frontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.78844
GTEX-UTHO-0726-SM-3GAEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01138
GTEX-T6MO-0008-SM-4DM6T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43804
CTCF_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
marrow cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Spleen-classical monocyte	Tabula Sapiens Gene-Cell Associations	1.0	1.71683
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23175
LMO2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE143643,GSE143644_4_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A-CA-04-2009(H1N1)_48Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.22024
Perturb_13248_OE_Med24_SRP201000	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.28408
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GRIN3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00642406
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5333-01A-01R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE190316,GSE190324_1_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Ovarian carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
Early endosome membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K06792661_Narciclasine_LOVO_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-4261	TargetScan Predicted Conserved microRNA Targets	1.0	0.181316
2658_EP400_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.675891
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7399-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_11215_KO_Gpr151_SRP359303	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.92339
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.996098
GSE62843,GSE64371_4_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Cytoplasmic vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE196117_6_v_8_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_1_TRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE218580_1_v_4_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.376
GSE110178_1_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
VZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.920218
GSE222758_0_v_1_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20637
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15307
GATA1_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC4006	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.97044
BRD-K35304243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14739
ETS1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5282
dorsolateral prefrontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.52249
GSE157555,GSE157556_3_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_14500_KD_RUNX1_SRP265128	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.01912
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
frontal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.965451
Esophageal squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.303
SYK_druginhibition_287_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.82971
GSE171292_6_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
bipolar affective disorder	GWASdb SNP-Phenotype Associations	1.0	0.445424
GSE135030_3_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BE-81-QL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.369269
GTEX-OHPK-0008-SM-4E3JL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10172
ORC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00345085
Perturb_11151_OE_Aeg1/Myc_SRP048459	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.4806
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.915
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I8-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H4K91ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.51345
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.20754
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9216
9473_U2AF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.57084
HDAC6	ENCODE Transcription Factor Targets	1.0	null
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Baboon_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10967149-12903_2024_4167_MOESM3_ESM.xlsx-LPS_VS_LPS_PDLSC-CM_776-Gene_symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Tumor Immunity	DisGeNET Gene-Phenotype Associations	1.0	null
KYSE410	CCLE Cell Line Gene Expression Profiles	1.0	1.47488
BRD-K14436020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48432
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.92095
BRD-K85722200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00582
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
B-cell chronic lymphocytic leukaemia-small lymphocytic lymphoma_Peripheral blood mononuclear cell_GSE8835	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.50837
Rumen epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.757
GABPA_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ8I-0126-SM-4BOPL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44892
PKMYT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44742
GSE164874_5_v_6_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.08764
BRD-K42455150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0227
GSE77108_6_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
STAT3-1855785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.5729
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5EA-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K58299615_Ro 90-7501_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.415011
GTEX-OXRK-0008-SM-3NB28	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07319
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE120216_3_v_0_cbfb_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213242
GTEX-WVLH-2926-SM-3MJG5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.991009
BRD-K61059900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15411
5165_MPHOSPH8_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.574518
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE188870,GSE188871_0_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SCH	COSMIC Cell Line Gene CNV Profiles	1.0	2.15316
BRD-K10707948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12114
Bronchogenic carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.437
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.14488
GP2D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Status Epilepticus	CTD Gene-Disease Associations	1.0	1.15223
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
UBLC1	CCLE Cell Line Gene Expression Profiles	1.0	1.44814
GTEX-QDT8-0526-SM-3NMD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49444
GSE198165,GSE198166_0_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE205291,GSE205292_1_v_3_drd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CHD2	ENCODE Transcription Factor Targets	1.0	null
GSE158815_5_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE188599_1_v_10_resolvin e1_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GT-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A1QS-01A-61R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hypertension	CTD Gene-Disease Associations	1.0	1.23042
BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_T3M10_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE157555,GSE157556_4_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Neutropenia	CTD Gene-Disease Associations	1.0	1.04088
9151_TNPO3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.558692
BRD-K81932943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33618
NELFE	ENCODE Transcription Factor Targets	1.0	null
Hoxa13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.6216
GSE166004_3_v_2_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WOFM-1326-SM-3MJFR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.967193
GSE135030_8_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_MC1568_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137832
FLI1-26923725-CHIP-SEQ-MACROPHAGESS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CHD7	ENCODE Transcription Factor Targets	1.0	null
TAMALIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13615
4941_MED19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.541949
TAS2R60	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00521136
GSE101527_0_v_1_smad4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_G007-LK_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0203373
gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042683
GTEX-SSA3-0008-SM-47JWJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947856
GSE147210_2_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
17910759-TableS5	GeneSigDB Published Gene Signatures	1.0	null
BRD-K66425065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17134
BRD-K01877528_TL_HRAS26_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
LMO2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
AD-89-LX67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301027
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A113-11A-12R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K60623809_SU11652_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE133683_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
primary auditory cortex (core)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.7692
TMEM265	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58542
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BCLAF1	ENCODE Transcription Factor Targets	1.0	null
STAT5B-24692510-EPITHELIUM-MOUSE-MAMMARY	ChEA Transcription Factor Targets 2022	1.0	null
primary motor cortex (area M1, area 4)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.59133
GTEX-XUZC-1626-SM-4BRVP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828404
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE182680,GSE182683_0_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE111385_0_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormality of lipid metabolism	GWASdb SNP-Phenotype Associations	1.0	0.390575
ASPH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00598025
EKVX	CCLE Cell Line Gene CNV Profiles	1.0	1.61717
NFIC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Colon - Sigmoid	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.49684
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.487861
GTEX-PWOO-0008-SM-48TDU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0418
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bioinformatics	GeneRIF Biological Term Annotations	1.0	null
GSE140322_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126402_5_v_3_tal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
non-small cell lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.449
Cholangiocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.266
BRD-K21588993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13548
KLF16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00835
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05295
PMC7220941-41598_2020_64431_MOESM2_ESM.xlsx-WS2_2019_Affy_IDs_SignalsQN-Unnamed_2_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K81139344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02233
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WASHC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08105
hsa-miR-548a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
BRCA1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EW-12	GDSC Cell Line Gene Expression Profiles	-1.0	-1.60004
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.956621
GSE152937_12_v_1_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6801_PRPF4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.537967
ko143	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.78
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-5155-01A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Tacedinaline_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163651
znf148_21828133_erythroblast_lof_human_gpl571_gse31092	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.122688
SPATA33	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00713478
BI-78D3_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0199359
BRD-K50201262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43271
hsa-miR-3126-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210101,GSE210114_5_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_11919_KD_PDPN_SRP071702	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.21017
BRD-K49742819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82991
K562_JQ1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012451
MCF7_Selisistat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157586
secretory granule membrane	GO Cellular Component Annotations 2023	1.0	null
PMC9746818-jciinsight-7-152886-s077.pdf-22-ENSG00000197619_ZNF615	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8011-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE171269_1_v_4_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65213
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
hsa-miR-128-3p	MiRTarBase microRNA Targets	1.0	null
SYK_druginhibition_290_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.55127
Disease Models, Animal	CTD Gene-Disease Associations	1.0	1.41721
ITGB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00660403
TEAD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4345-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE233183,GSE233187_2_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Ray floret	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.581
FLI1	ENCODE Transcription Factor Targets	1.0	null
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21907
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.903805
Tongue cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.772
GTEX-QEL4-0626-SM-3GIJM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12335
SPI1-26923725-CHIP-SEQ-MACROPHAGESS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CBX8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4512-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95076
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.958848
Ovarian Diseases	CTD Gene-Disease Associations	1.0	1.28395
GTEX-QVJO-0126-SM-3GIK4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28455
BRD-K60713831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1295
inner CP in (rostral) midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30299
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6319725-pone.0204197.s006.xlsx-Table_S2-S2_TABLE_-_Operon_Expression_and_SOM_clustering_data_for_Gene_Set_identified_by_ANOVA_p_0_005_1005_genes_FDR_8_8_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
Skeletal Muscle Female	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.29606
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7866-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XUYS-0326-SM-47JX2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25469
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.896757
GB-16-SU72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.44841
Skin Diseases	CTD Gene-Disease Associations	1.0	1.03864
H2BK20ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-5420-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RUNX1-22412390-EML-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE124097_3_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.05424
hsa-miR-635	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
azurophil granule membrane	GO Cellular Component Annotations 2025	1.0	null
16498405-TableS10	GeneSigDB Published Gene Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19L-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
t60-adrenal_female_2w	MoTrPAC Rat Endurance Exercise Training	1.0	1.35479
caudal (posterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.877129
ZNF24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3929
Hyperplasia	CTD Gene-Disease Associations	1.0	1.42535
BRD-K57027644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77391
posteroventral (inferior) parietal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.07286
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4890-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE60837_0_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.581726
hsa-miR-4645-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.29983
BRD-K96076993_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pericardial Effusion	CTD Gene-Disease Associations	1.0	1.03197
SLC5A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0053675
Early endosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Lung adenocarcinoma_LUAD_TCGA-38-4632-11A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
2122_DDX46_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.507541
GSE205316,GSE205317_0_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K06094529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6721
CRCGN013_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.02757
GTEX-PLZ6-1526-SM-2S1OC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34831
SARS-CoV_60Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.35143
primary visual cortex (striate cortex, area V1/17)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25223
Anaplastic large cell lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.519
GTEX-QVJO-1426-SM-2S1QY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836599
BRD-K04853698_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Thrombocytopenia	CTD Gene-Disease Associations	1.0	1.13041
CRCGN013_HEPG2_24H:B07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.62892
A549_Lomustine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164857
Perturb_362_KD_RAC1_SRP387923	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.17368
GATA1_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193258,GSE193259_2_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
amygdaloid complex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.999537
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3453-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.63975
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.62273
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.826
Perturb_12185_KD_LATS1/LATS2/TP53_SRP065500	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.62663
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Up_bins-Up_bins_gaining_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K20525312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24732
GSE137818_5_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
atherosclerosis	GWASdb SNP-Disease Associations	1.0	1.42467
DE-82-SC55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.335153
CAL27	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36021
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
A-375 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.923
GTEX-XQ3S-0008-SM-4GIDZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41415
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WV-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
K562_Sorafenib Tosylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170582
inner CP in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.830856
TA-57-FF07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.253823
CACNG8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50749
STK32A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00569508
BRD-K08408085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.39925
2204_DHX16_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.572097
posterior (caudal) superior temporal cortex (area 22c)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.22056
BRD-A41199690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26591
testis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.245491
hsa-miR-1246	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Peripheral_Blood_Mononuclear_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.04588
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
GSE180147_0_v_1_itga5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K50593511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51083
7157_RBM14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.668068
GTEX-WZTO-1326-SM-3NM8X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04876
GTEX-XMD3-0008-SM-4AT4V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2003
hsa-miR-192-5p	MiRTarBase microRNA Targets	1.0	null
DBTRG05MG	DepMap CRISPR Gene Dependency	1.0	2.67258
DNMT3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89987
GATA1_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-GH-A9DA-01A-21R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-DX-A1L4-01A-12R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Headache	CTD Gene-Disease Associations	1.0	1.12668
GTEX-S4Z8-1826-SM-3K2BH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.992779
CTCF_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6291_PHF5A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.601275
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.31776
BRD-K91018728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74158
GTEX-QVUS-2926-SM-3GIJB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07236
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050952
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.612974
GTEX-UJHI-0008-SM-4IHL1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70786
oculomotor nuclear complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.13532
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Gene_Name_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53953065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11448
BRD-K90697692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05167
GB-73-QS80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.470565
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A822-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE199899_4_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
496100588_TCx_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.28522
Lung adenocarcinoma_LUAD_TCGA-55-8511-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210476_11_v_10_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A36275421_2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MRPS30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1379
BRD-A18411371_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Schwann cell microvillus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.051
GTEX-S4P3-0008-SM-3NM8R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17078
CDK4_knockdown_133_GSE31534	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.38067
LMO2	ChEA Transcription Factor Targets	1.0	null
TF-77-DW08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294155
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.871467
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GTEX-TSE9-0011-R4A-SM-3DB7H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05818
DIFI	DepMap CRISPR Gene Dependency	1.0	4.25273
AB-00-IL62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345909
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF384	ENCODE Transcription Factor Targets	1.0	null
GSE103068_0_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_6503_KD_PIEZO1_SRP140640	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.94762
PMC9376070-41419_2022_5157_MOESM15_ESM.xlsx-Sheet1-Table_S1_Differentially_expressed_genes_of_CYTOR-KD_and_NC_cells_identified_in_the_RNA-seq_analysis_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.886749
RNF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31858
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE242290_1_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.79405
GSE218060_1_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
cisplatin_homo sapiens_gpl570_gse23553	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S33H-0008-SM-4AD6C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54794
inner CP in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0901
16488994-SuppTable1a	GeneSigDB Published Gene Signatures	1.0	null
POLR2A_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CG-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE159937_1_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03609
embryoday10.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.10176
VZ in rostral cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08035
MOTN1	CCLE Cell Line Gene Expression Profiles	1.0	1.68403
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K12107412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2199
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_342_KD_GDF6_SRP076553	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
BRD-K65005311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42858
IGFBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23901
subiculum, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.961904
Long QT Syndrome	CTD Gene-Disease Associations	1.0	1.06008
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE180185_4_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZFX_KO_GDS2718_151_mouse_hematopoietic stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
MYOG	ENCODE Transcription Factor Targets	1.0	null
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XLM4-3026-SM-4AT6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08548
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.88142
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
1583_CHMP3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.814043
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K06426971_Ryuvidine_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.10089
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MON	DepMap CRISPR Gene Dependency	1.0	2.94743
GSE95688_1_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
8184_SMN2_ENST00000380743.4	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.745798
globus pallidus, external segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.858084
GSE221539_1_v_3_lrrc10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.34862
8345_SPEG_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.893695
GSE193993_4_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242049_1_v_0_txndc5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MELTF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00599187
respiratory system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CRCGN012_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7404
Perturb_4701_KD_Srsf3_SRP265820	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
CF-91-JY05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.318537
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.34862
Lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.424
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.926706
GTEX-OIZG-0008-SM-4E3J2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37311
GTEX-PWCY-0008-SM-48TE9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05564
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Monocyte_Fetal kidney_Human	CellMarker Gene-Cell Type Associations	1.0	null
AB-09-EA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203959
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ChIP_SETDB1_19884257	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Total cholesterol levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.739794
NCI-H446	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.48992
Liposarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.802
6791_PRPF18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.51914
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.49739
Thyroid cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
AA-11-RO46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217666
H3K4ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19372
hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7287-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.145703
GTEX-WHSE-2926-SM-3NMBG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922006
GTEX-WZTO-0826-SM-3NM8Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46127
GSE149264,GSE149267_9_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-4468	TargetScan Predicted Conserved microRNA Targets	1.0	0.17031
GSE130383_2_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7774_SENP5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.50931
ATP13A2	Pathway Commons Protein-Protein Interactions	1.0	null
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine corpus endometrial carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.242
BRD-K04853698_-666_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAFF	ENCODE Transcription Factor Targets	1.0	null
BRD-K29338816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29076
GSE193258,GSE193259_9_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K31297909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52932
GSE231891_1_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE224131_2_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	1.0	null
MEWO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.62
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE77108_4_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T6MN-2626-SM-32PMQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899315
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE101537_1_v_3_neurog3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
a549	HPA Cell Line Gene Expression Profiles	-1.0	-0.83656
BRD-K31030467	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89042
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF1	ENCODE Transcription Factor Targets	1.0	null
pituitary	GTEx Tissue Gene Expression Profiles	-1.0	-0.828298
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
BRD-A79097167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.496
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.337009
Esophageal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.181
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE189683_3_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
experimental	GeneRIF Biological Term Annotations	1.0	null
BRD-K63375777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15715
inner CP in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.985339
HOP62	CCLE Cell Line Gene CNV Profiles	1.0	1.39136
bone marrow	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
645_ATP1A1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.632528
BRD-K53198140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14662
epithelium	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN016_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.90161
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50734
BRD-K49075727_nintedanib_A375_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-507	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.96387
HCC70_BREAST	CCLE Cell Line Proteomics	1.0	2.3084
GSE210476_11_v_3_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052151
Perturb_5172_KO|KD_Sirt1|Otx2_SRP075247	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
PMC4860404-Table2.XLSX-MR_unique-Table_S2-7_DEG_unique_in_mouse_and_rat_SCI_at_3_dpi_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RU72-1326-SM-2TF6T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03179
CRCGN016_MCF10A.TP53.M_24H:D20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.82794
PA-TU-8988S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.46956
KYSE450_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	2.15976
extracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
EGR1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE137325_2_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BT474	CCLE Cell Line Gene Expression Profiles	-1.0	-2.1063
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0494
Thymic cortical epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.024
Cervix - Endocervix	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.16224
8680_TANGO6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.643037
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73849129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25074
VZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.896077
Malignant exocrine pancreas neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.544
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SYK_druginhibition_284_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.28022
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Endosome membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
secretory granule membrane	GO Cellular Component Annotations 2025	1.0	null
GSE174701_1_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
cyclosporine_homo sapiens_gpl570_gse15935	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TIAM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00599415
Perturb_6968_KD_Dnmt3a_SRP075146	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.87646
angular gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09419
20081105-Table2	GeneSigDB Published Gene Signatures	1.0	null
BRD-K74148702_curcumin_MCF7_24.0_h_48.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-U8T8-1426-SM-3DB9H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22987
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-0.995387
Hoxd13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.2675
HEC1B	CCLE Cell Line Gene CNV Profiles	1.0	1.88332
EPCAM_OE_GDS4887_343_human_IL-28B	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-7_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XOTO-0011-R5A-SM-4B657	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11866
GSE195568_3_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-N7MT-0011-R8a-SM-2I5GU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839334
6708_PPWD1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.536098
TTA-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.672
BRD-A89681034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47987
MYBL2	ENCODE Transcription Factor Targets	1.0	null
GTEX-WWYW-0011-R1A-SM-3TW8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1919
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-W5X1-0826-SM-3GILN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26111
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE127790_13_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D4-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE225656_0_v_1_tsc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142684_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210580_5_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A79465854_auranofin_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
978_C14ORF178_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.658825
Perturb_17366_KD_SRSF6_SRP309439	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.85411
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K00119817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07948
Rab-protein geranylgeranyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.78
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.92753
GSE210101,GSE210114_8_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7006-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.47865
BRD-K43548664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66728
SNU1544	DepMap CRISPR Gene Dependency	1.0	4.97183
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4433-01A-22R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Clear cell renal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.479
TAL1_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IE-02-TR35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.421189
skeletal system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE136742,GSE136744_0_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6504
BRD-A98888138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44197
PMC8321693-LSA-2021-01139_TableS6.xls-S6-1-Table_S6_Candidates_of_HOTAIR_and_YBX1_co-regulated_genes_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
GABPA_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K29458283_chlorambucil_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE48812_8_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-3118	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE211128_4_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
inferior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.3067
GTEX-QXCU-0008-SM-48FCH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04742
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.37274
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-5_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.22366
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10X-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE137144_3_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07387
CRCGN008_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4775
H4K5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7652-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YJ-A8SW-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE87617_1_v_0_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PACADD188	DepMap CRISPR Gene Dependency	1.0	3.66928
GTEX-UTHO-0011-R6A-SM-3GIJW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.03426
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RM-01A-21R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE137144_5_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TMMY-0008-SM-4DXU3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.99464
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
nasopharynx carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.241895
CRCGN014_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3945
GSE208634_1_v_2_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
wt1_17420277_e11dot5_urogenital_ridge_lof_mouse_gpl1524_gds2747	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.252958
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00135
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.324772
L-428	GDSC Cell Line Gene Expression Profiles	1.0	1.74973
BRD-K24499562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33163
CRCGN015_HEPG2_48H:M12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12418
CREM	ChEA Transcription Factor Targets	1.0	null
cisplatin_mus musculus_gpl339_gse6206	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE203308_4_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE70499_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AKT1_knockout_212_GSE39699	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.06636
DC-13-RZ62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203987
KIT_activemutant_55_GSE17743	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.65019
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A64957606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3382
Endocervical carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.089
Perturb_6606_KD_CMTM6_ERP123354	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
CC-93-RP38_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233722
BRD-K77743611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02453
SK-N-AS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.39599
fallopiantube_8d	HPA Tissue Sample Gene Expression Profiles	1.0	1.46128
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209747
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.843
9837_WDR70_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.533706
GSE57871_11_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
extracellular region part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.9276
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.22749
primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.41016
BRD-K51054674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06077
LDL cholesterol	GWAS Catalog SNP-Phenotype Associations	1.0	0.434785
hsa-miR-92a-3p	MiRTarBase microRNA Targets	1.0	null
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.827317
BRD-K30312557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36437
Large B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.076
striatum_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12
PMC6606599-41598_2019_45777_MOESM14_ESM.xlsx-SAVA_DE_genes_promoter_DMRs-Unnamed_29_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.73033
GSE149075_1_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.336418
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TY-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7691587__F3	PFOCR Pathway Figure Associations 2024	1.0	null
H3K79me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Peripheral blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.852
MCF7_Luminespib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137362
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.986964
Oligospermia	CTD Gene-Disease Associations	1.0	1.27845
GSE188870,GSE188871_0_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K05402890_17757146_HT29_24.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE201217_4_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UJMC-1826-SM-3GADT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880188
GTEX-SN8G-0008-SM-4DM4X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14369
BRD-K23782109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36936
A549_Pelitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137627
Methionine	CTD Gene-Chemical Interactions	1.0	null
MCF7_Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012651
GTEX-XUJ4-2626-SM-4BOQ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.82471
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K56563758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00586
CRCGN014_HEPG2_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73972
hsa-miR-4422	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
STAB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0045317
GSE196259_2_v_0_gcm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6357748-aau9223_Table_S1.xlsx-CD4_T_-_LPS-Unnamed_0_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QDVN-0008-SM-48U2D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24352
A549_S-Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0109832
Lung adenocarcinoma_LUAD_TCGA-44-6146-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7540-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-E2A_Pre-Pro-B-Cells_ChIP-seq_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
GATA1_G1E-ER4_mm9_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE145311_1_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.875378
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.8741
DD-30-SX80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.365042
GSE178340_5_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K92428232_GSK-461364_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BTK_knockout_2_GDS1346	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-0.099186
CAL-27 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.555
H3K18ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NR1H3-23393188-ATHEROSCLEROTIC-FOAM-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE190316,GSE190324_6_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217694_4_v_0_pold1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NELFA-20434984-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GATA1	ENCODE Transcription Factor Targets	1.0	null
CTCF_mammary epithelial cell_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HOXA5	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-XOTO-0008-SM-4GICE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27576
SMIM15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30089
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.135936
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
CDK2_knockdown_132_GSE31534	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.01043
GSE148066,GSE157787_0_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ARID3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RVPU-0011-R7A-SM-2XCAB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.3348
Perturb_15118_KD_DNMT3A_SRP054246	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.4272
GSE213228_4_v_3_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-3770-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JVE127	DepMap CRISPR Gene Dependency	1.0	2.2754
H3K23ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE140651,GSE140653_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TMMY-1126-SM-4DXSX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845931
RKO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.982
GTEX-X585-0008-SM-46MU4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58777
GTEX-SNMC-0826-SM-4DM66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58111
NUGC-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.44336
BRD-K61551681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49686
GSE148200_4_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pancreatic cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.366
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and neck carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.962
GTEX-RNOR-2326-SM-2TF4I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.09054
MDA-MB-436 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.893
Thyroid gland disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
MCF7_Decitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178431
CRCGN015_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3248
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873721
BRD-U60236422_WH-4-025_A549_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64919
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.929097
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JI-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.28467
GSE199606_2_v_7_csf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SM-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_17532_KD_C1QBP_SRP270881	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
ZR75B	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.42168
SYK_knockdown_189_GSE54065	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.56751
P30OHK	DepMap CRISPR Gene Dependency	1.0	2.12951
PMC4521181-oncsis201520x8.pdf-29-TBX18_TBX18	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.946905
PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R3RS-0008-SM-48FF1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843561
Ovarian cystadenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.207
8157_SMC3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.532018
PTK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00355643
PMC10055287-media-6.xlsx-intersection_genes_up-FOXJ1_FOXJ1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE70499_5_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
uterus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056802
C99	DepMap CRISPR Gene Dependency	1.0	4.24521
hsa-let-7b	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
primary motor-sensory cortex (samples)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.995897
BRD-K68495784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70204
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.85874
CADOES1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50208
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08069
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-let-7f	TargetScan Predicted Conserved microRNA Targets	1.0	0.293524
GSE230263,GSE230265_0_v_1_runx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_6624_KD_DDX5_SRP237546	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.22595
BRD-K47150025_Ki 8751_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE228106_0_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K90879242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04066
hsa-miR-548f	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
7186_RBMX2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.724162
BRD-A77292814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49256
GSE221327_8_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FE-64-KC49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.907959
GSE95688_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE217105_0_v_1_gemcitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
cerebellar cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.97582
Lung adenocarcinoma_LUAD_TCGA-50-5066-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Altretamine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149664
K562_Danusertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183233
GSE86507,GSE86509_0_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.518021
REEP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39238
IFFO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15185
DNMT3B	Pathway Commons Protein-Protein Interactions	1.0	null
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051831
GSE149035_1_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1518
GTEX-OHPL-0008-SM-4E3I9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89982
BRD-K82609503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18185
GSE44157,GSE44163_1_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168796
BRD-K08996393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53435
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.90118
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209729
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.761
GSE93309_2_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_Rectal Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
496100330_PCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.01793
20081105-ST-1	GeneSigDB Published Gene Signatures	1.0	null
Bone marrow cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Blood	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN016_MCF10A.TP53.M_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2471
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01056
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
N6AMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63233
Lipidoses	CTD Gene-Disease Associations	1.0	1.18587
MCF7_Navitoclax_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188367
NCIH292	CCLE Cell Line Gene Expression Profiles	1.0	1.67024
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.37334
GSE87144_3_v_1_rorc_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_10_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bronchial epithelial cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.363
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_10_v_6_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_6502_KO_SOCS3_SRP168556	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.86741
GSE255432_7_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A72180425_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TMEM60	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4143
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE207787_3_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7648632__F1	PFOCR Pathway Figure Associations 2023	1.0	null
10029_ZC3H8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.615122
608_ATF5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.646687
GTEX-S4Z8-0008-SM-33HAZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90858
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1432
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0079
RPEL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49042
GSE213611_1_v_0_nuf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K67586245	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13975
OV7	CCLE Cell Line Gene CNV Profiles	1.0	1.67415
GSE95077_1_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.98895
TE-8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Endocrine pancreas	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.21
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.039
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5552-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STAT5A-24692510-EPITHELIUM-MOUSE-MAMMARY	ChEA Transcription Factor Targets 2022	1.0	null
GSE218060_1_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SARS-ddORF6_60Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.60298
KDM5B	ChEA Transcription Factor Targets	1.0	null
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE216043_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	1.0	2.82322
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.19647
HEC-1-A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.69231
GID8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58268
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.15086
GTEX-RU1J-1726-SM-2TF5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03462
Cervical cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.358
DC-22-OP01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.403111
GSE101112_0_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213219_2_v_3_st3gal3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
1588_CHMP6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.704636
VMCUB1	CCLE Cell Line Gene Expression Profiles	1.0	1.86923
GSE191037_0_v_1_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Bosutinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152695
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.527662
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TOLEDO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18503
Perturb_13140_KD_Rb1_SRP158002	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03116
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE160246_9_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mouth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.696
6797_PRPF3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.754491
ATF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
superior colliculus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.30468
AD-65-WK61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263674
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.58329
GSE158853_0_v_1_hmgcs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VF-79-GQ03_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218641
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39V-11A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chemotaxis	GO Biological Process Annotations 2015	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YT-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.575672
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.728
GSE120248,GSE120252_1_v_0_macf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228413_2_v_5_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_8448_KD_ABL1_SRP212071	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3662	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE158197_0_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160304,GSE163392_4_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
extracellular space	GO Cellular Component Annotations 2015	1.0	null
PMC6344081-elife-40364-supp5.xlsx-PLZF_peaks_H3K27Ac_gain-Unnamed_10_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K76263570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59415
BRD-K12513978_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K12750296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35235
primary auditory cortex (core)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.861526
PROZ	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0033241
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.16
inner CP in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03424
Brain Lower Grade Glioma_LGG_TCGA-DU-6404-02A-21R-A36H-07,TCGA-DU-6404-02B-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100629_HIP_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04427
hsa-miR-532-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73A-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39Z-11A-21R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-DX-A1L2-01A-22R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF354A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49854
BRD-K52500055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15889
BRD-K82681356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0156
BRD-K68435627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29272
Esmolol (hydrochloride)_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0188656
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X261-0011-R7A-SM-4E3JJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.867696
GSE131903_0_v_2_abca12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NRBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00680341
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.112483
BRD-K52551495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12225
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.84182
BRD-K83336168_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K64221857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12522
BRD-K68086276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16283
GSE100316_0_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SYK_druginhibition_283_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.0896
BRD-K22674439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25679
BRD-K40241022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04567
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
1219_CBFA2T3_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.533597
BRD-K47887272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69031
Levobupivacaine (hydrochloride)_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0157121
NB4	DepMap CRISPR Gene Dependency	1.0	9.11109
Lysosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.496458
adult stem cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2925_FAM50A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.621233
GNMT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00768405
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052164
combination	GeneRIF Biological Term Annotations	1.0	null
GSE210580_5_v_2_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_3_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09483
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7PM-0008-SM-3NM9Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20733
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.416948
disease	GWASdb SNP-Disease Associations	1.0	0.055124
VIIAf	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.911985
H3K79me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
gata3_21892208_mda_mb_231_gof_human_gpl570_gds4080	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.273591
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_induced_genes-Unnamed_6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GSE195513_2_v_1_cpeb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FC-05-LX47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205338
OCILY18	DepMap CRISPR Gene Dependency	1.0	2.55198
GSE182835,GSE182836_0_v_1_siah2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-O5YW-0326-SM-2I5EI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05077
GSE196259_2_v_3_gcm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	1.0	2.64105
GSE136622_0_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8102188-41375_2021_1231_MOESM4_ESM.xlsx-t_som_AA_healthy-Unnamed_7_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.06083
H3K27ac_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-POYW-0526-SM-2XCEY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.924952
SNGM_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	7.9229
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.06181
GTEX-O5YW-0008-SM-4E3IE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00613
GTEX-QLQ7-0008-SM-447AW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01758
GSE232944_1_v_0_ctnnb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100578_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.21934
BRD-K28360340_TW 37_NCIH596_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MCF7_Nilotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138189
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.980977
monocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
SCC-9	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.25982
8238_SNW1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.715763
EP300_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147876,GSE147877_4_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SNMC-1226-SM-2XCFP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879846
GSE108326_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
B16-F10 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.279
MSC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17296
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q3-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.52803
A549_Panobinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120287
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CHRNA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50064
hsa-let-7c	TargetScan Predicted Conserved microRNA Targets	1.0	0.293524
GSE178714_6_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Celecoxib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139846
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE129186,GSE129223_0_v_1_aicda_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4317_KDM1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.556074
BRD-K22670776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55194
GABPA_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WXYG-2526-SM-3NB3F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.4998
BRD-A02481876_Importazole_A375_24.0_h_60.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
GSE239578_0_v_4_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.64958
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.955975
XRCC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55961
PMC9730246-Table_7.xlsx-LPS_Val_up-Upstream_Regulator_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
HNF4A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Micropinosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.529
Hnf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.7134
GSE223334_1_v_0_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T5JC-2426-SM-3NMDB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44445
GSE197555_0_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7473-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCFC1	ENCODE Transcription Factor Targets	1.0	null
KYSE-150	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.39862
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Symbol_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE218814_1_v_0_suv39h1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1701
GSE200352_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
orbital frontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.92503
GSE158834_11_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K74797618_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-515-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
SLC45A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00454064
Immune System	Reactome Pathways 2024	1.0	null
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XOT4-0008-SM-4B664	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12921
Axolemma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.552
CDK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00329553
Perturb_14905_KD_LIN41_SRP032743	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.20786
GTEX-UPK5-0008-SM-4IHJD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32751
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5888-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210580_5_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FGR	MSigDB Cancer Gene Co-expression Modules	1.0	null
PMC10792109-NIHMS1929238-supplement-Supplemental_Table_6.xlsx-intersection_genes_up-FOXJ1_FOXJ1	Rummagene Transcription Factor Associations 2026	1.0	null
HCC2157	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54028
hsa-miR-3667-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
A549_CEP-33779_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165465
BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_A549_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE215086_5_v_0_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE222758_0_v_3_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
male reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062551
GSE185635_0_v_1_ncor1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FLI1-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159685
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.34926
MYBL2	ChEA Transcription Factor Targets	1.0	null
ventrolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04871
PANC 02.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.84182
BRD-K59847773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27366
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.73336
GTEX-QV44-2026-SM-2S1RD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57738
MCF7_IOX2_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153355
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.903283
A549_Aminoglutethimide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139167
GSE220520_3_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cisplatin_mus musculus_gpl339_gds3099	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Non-Small Cell Lung Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-A25687296_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.74089
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.84628
Vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Prostate adenocarcinoma_PRAD_TCGA-G9-6347-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
HNF4A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMT5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32083
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17
paclitaxel_homo sapiens_gpl570_gse11550	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7726-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE136622_6_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K14567490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13182
18593951-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00487709
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.45342
Perturb_3885_KD_EIF2B5_SRP124930	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.8072
brain_3b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.884925
Squamous cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.014
H4K20me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
craniofacial region	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.346668
Prostate adenocarcinoma_PRAD_TCGA-G9-6369-01A-21R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PSMB8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11044
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
SKM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.93971
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cholesterol, total	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.769897
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.896234
HCC1419	DepMap CRISPR Gene Dependency	1.0	3.03866
EMC-BAC-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.01558
GSE190316,GSE190324_1_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Cediranib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147323
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220863
HUP-T4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.930399
BRD-K74834319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04833
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.495894
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.886
bexarotene_homo sapiens_gpl96_gds2777	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PROX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1944
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7PM-0526-SM-3NM92	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4197
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.768
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-1526-SM-2D7VU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08024
BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_THP1_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IKZF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARS-BatSRBD_84Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.82855
GSE185944_5_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mcf7	HPA Cell Line Gene Expression Profiles	-1.0	-0.930335
MCF7_Tanespimycin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0102208
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KAT2B	ENCODE Transcription Factor Targets	1.0	null
GATA1_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cloned	GeneRIF Biological Term Annotations	1.0	null
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU2F2_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4013678__F2	PFOCR Pathway Figure Associations 2024	1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.06673
BRD-K72379955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03705
BRD-K34106082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06453
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
SAP30	ENCODE Transcription Factor Targets	1.0	null
CRCGN013_HEPG2_24H:I14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05535
Six4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.0541
AC-50-FR41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285718
PMC11058205-42003_2024_6202_MOESM5_ESM.xlsx-Data2c_CEBPA_ChIP-Unnamed_9_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
sclc21h	HPA Cell Line Gene Expression Profiles	-1.0	-2.00556
NFIC_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SARS-dORF6_96Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.75321
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.825
ventrolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34028
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K78500251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09075
NFIC_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN010_HEPG2_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6936
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.2393
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MAP4K5_knockdown_199_GSE61497	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.37491
Perturb_16660_KO_Vhl_SRP350537	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_TG101209_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134062
LRRC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01864
hsa-miR-504	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
BRD-K12502280_TG101348_NCIH508_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.89686
Sarcoma_SARC_TCGA-DX-A1KU-01A-32R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KMT2C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0056623
FOXA1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K17743125_belinostat_HEPG2_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S95S-1426-SM-2XCDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88942
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS 675.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12099
BRD-K84710243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08598
BRD-K07576726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70693
OVCA 420	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08274
hsa-miR-589	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
azurophil granule	GO Cellular Component Annotations 2023	1.0	null
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.11925
protein transport	GO Biological Process Annotations 2025	1.0	null
chr3_32502356_G_C_b38	GTEx eQTL 2025	1.0	1.29082
GTEX-R55E-1026-SM-2TC5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05988
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11398
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XYKS-0008-SM-4BRW6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979802
Prostate adenocarcinoma_PRAD_TCGA-EJ-7788-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
HNF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42458
BRD-K70792160_Akt inhibitor X_SKM1_6.0_h_24.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
telmisartan_rattus norvegicus_gpl4135_gse29445	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11801
GSE246195,GSE246305_1_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184902_3_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7235-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CENPU	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00765591
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00275
GSE190316,GSE190324_6_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.875378
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GATA1_G1E-ER4_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73475697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.065
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	1.0	null
imatinib_homo sapiens_gpl96_gds3043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H4K91ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE119694_1_v_0_lifr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TE14_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	2.1592
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-BI-A0VS-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE178340_1_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cognitive disorder	GWASdb SNP-Disease Associations	1.0	0.855302
GTEX-OHPM-0008-SM-4E3IP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4118
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.072221
GSE168918_1_v_0_tmprss4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE167324_2_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GATA1_G1E-ER4_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A52893269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67167
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.74483
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.755063
GSE57871_8_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CB-31-UO16_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264492
GTEX-N7MT-0011-R10A-SM-2I3E1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926116
496100604_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.15018
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K16057611_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.784072
GTEX-WWYW-3026-SM-3NB36	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824247
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
Ovarian serous cystadenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.173
BICR31	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41199
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_1594_KO_Rpl23a_SRP056432	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.88046
GSE143316_0_v_6_somatostatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BD-96-HO33_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.44474
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MLX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30642
7508_RPS19BP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.528591
BHY	CCLE Cell Line Gene Expression Profiles	1.0	2.16823
GSE232631_5_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TRIM24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00585002
BRD-K04409515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10037
BRD-K80782159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22921
BRD-K37486644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.76149
Seizures	CTD Gene-Disease Associations	1.0	1.26917
recycling endosome membrane	GO Cellular Component Annotations 2023	1.0	null
GSE51684,GSE51741_2_v_4_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ribose phosphate diphosphokinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.731
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.890135
protein binding	GO Molecular Function Annotations 2015	1.0	null
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
SETDB1-19884257-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
heart_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.8769
Nasopharyngeal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.218
BRD-K16802067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12367
GSE207582_4_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217115_2_v_4_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TOP2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00495323
ASH2L-23239880-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE246461,GSE246463_5_v_0_mecp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
DD-17-HS50_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217073
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Baboon_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WL46-0011-R2A-SM-3LK6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22417
CA-96-UO48_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203513
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.492
Prostate adenocarcinoma_PRAD_TCGA-YL-A9WI-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.831128
GTEX-SE5C-0008-SM-4B64J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04606
CAL-120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.6178
INTS4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00631159
LS-513	GDSC Cell Line Gene Expression Profiles	1.0	1.58067
PMC9601604-NIHMS1841143-supplement-SuppTable-3.xlsx-shared_downregulated-Genes_downregulated_in_the_absence_of_FOXO3_in_GSCs_and_aged_NSCs_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
dh82	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.884
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
MCF7_Quercetin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013764
blast cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K51573654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82219
HPBALL	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44255
PSN1	CCLE Cell Line Gene CNV Profiles	1.0	1.39038
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CB-87-RB49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211767
hsa-miR-4789-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
CRCGN016_MCF10A.TP53.M_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.70066
Sarcoma_SARC_TCGA-DX-A2IZ-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.011
BRD-K68202742_trichostatin A_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE135352_2_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Gfi1b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.1181
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1703_LUNG	CCLE Cell Line Proteomics	1.0	2.51037
GSE154464_1_v_2_cdk6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SCH	DepMap CRISPR Gene Dependency	1.0	2.17572
membrane part	GO Cellular Component Annotations 2015	1.0	null
GSE143782_3_v_4_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.956
MD-86-UW46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250532
GSE195582_3_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K60812542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17785
BRD-K30707190_PNU 74654_A375_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_7813_KD_TMEM258_SRP092599	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.97424
GSE111247_14_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
dorsolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.65096
STAT5A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.42
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5681-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-N7MT-0011-R7a-SM-2I3FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.988969
BRD-K80622725_STK397047_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HK-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.41794
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.913
496100448_TCx_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.16528
Lung squamous cell carcinoma_LUSC_TCGA-56-7222-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
KCTD16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00530373
GSE210101,GSE210114_6_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
PMC9884267-41467_2023_36114_MOESM4_ESM.xlsx-dereg_genes_upon_HMG20A_siRNA_p-Unnamed_0_HMG20A	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE145215_2_v_1_krt13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPL13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00844831
GSE85880,GSE85881_0_v_2_tretinoin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_3_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7897682-Table_4.xlsx-S4E_-_CD14_Monocytes_and_THP1-Unnamed_2_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220401
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HAND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09717
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6824-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14628_KO_MSLN_SRP199242	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.74501
hsa-miR-140-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
SNU1196	DepMap CRISPR Gene Dependency	1.0	2.45322
FOXM1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IMR-32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.959854
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM1A	ENCODE Transcription Factor Targets	1.0	null
GSE160817_5_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CA1 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.407
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.12403
layer III of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.55659
SIRT6	ENCODE Transcription Factor Targets	1.0	null
GTEX-N7MT-0011-R3a-SM-2I3GC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.984218
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ND-39-PO34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.501038
CBX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00531496
Uterine Carcinosarcoma_UCS_TCGA-ND-A4WC-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_2156_KO_Tnfaip3_SRP126279	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.49208
BC-13-OQ01_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269249
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNF4G	ENCODE Transcription Factor Targets	1.0	null
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.841745
GSE236003_2_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.91651
GTEX-P4PQ-0008-SM-48TDX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840216
4154_INTS9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.678849
GTEX-QLQ7-1726-SM-2S1QQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24564
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.43057
BRD-K22944782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.09578
GTEX-RNOR-0011-R7A-SM-2TF4V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75298
BRD-A75954196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84165
BRD-K13662825_dinaciclib_HCC515_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN009_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.64795
CD14+_Monocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.17718
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-134	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Coma	CTD Gene-Disease Associations	1.0	1.07022
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.075295
Brain Lower Grade Glioma_LGG_TCGA-DU-7290-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDS - Myelodysplastic syndrome_Bone marrow stem cell_GSE2779	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.6656
SU-DHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.919074
KYSE-410	GDSC Cell Line Gene Expression Profiles	1.0	1.41947
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SIU8-0008-SM-4BRUC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0057
Nuclear cohesin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.601
Central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.664
HES4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50652
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32663
BRD-K70262646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2629
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUW1-0005-SM-4BOQ7	GTEx Tissue Sample Gene Expression Profiles	1.0	2.13781
Oral squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.973
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.405702
GSE234340_9_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11563688-jci-134-173448-s017.xlsx-EC2-gene_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SN8G-0326-SM-32PLG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892063
BRD-K78972225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58954
Perturb_14574_KO_EP300_SRP336466	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.80761
PMC3636213-pgen.1003459.s012.xlsx-Sheet1-KD_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8212786-DataSheet_4.xlsx-CESC-ZBED3_ZBED3	Rummagene Transcription Factor Associations 2026	1.0	null
CHD8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00550059
KCNQ5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00479848
BRD-K32501161_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Rifaximin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.27
PMC3677161__F5	PFOCR Pathway Figure Associations 2024	1.0	null
GF-46-LK68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.424558
4955_MED4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.999451
BRD-K53732802_VU0365118-1_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Respiratory epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.363
Oral squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.251
893_BRD8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.563124
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.854
TAL1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.11785
RFX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TGFBR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0196492
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051493
BRD-K81647747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42687
BRD-K74881104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09629
STX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47006
GTEX-XOT4-0526-SM-4B66O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12417
BRD-K47951859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10099
blood platelet	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.608306
GSE88819_6_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF4-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE99875_2_v_0_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6363-01A-21R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-let-7g	TargetScan Predicted Conserved microRNA Targets	1.0	0.248923
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Whole Blood	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.18755
GTEX-TKQ1-1426-SM-4GICK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870446
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.409732
Perturb_12236_KO_HIF1A/HIF2A_SRP130942	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.35712
BRD-A62995832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15473
GTEX-WZTO-0011-R4A-SM-3NMC7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21164
Lung adenocarcinoma_LUAD_TCGA-44-A4SS-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE185519_4_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WFG8-0008-SM-4LVN6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3459
BRD-K00507184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6504
BRD-K12593465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42334
Perturb_7239_KO_CDK8_SRP271652	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
IC-05-AW29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.326906
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
sequences	GeneRIF Biological Term Annotations	1.0	null
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5WG-0008-SM-4KL25	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14753
CTCF_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE232714_0_v_1_raver1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.821
H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Pancreatic islet	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.21
GSE213228_4_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
olaparib_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0191238
GSE189941_1_v_2_kdm4c_human	RummaGEO Gene Perturbation Signatures	1.0	null
membrane	GO Cellular Component Annotations 2015	1.0	null
GSE228727_2_v_0_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RTLS-0826-SM-2TF5Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21027
Brain Lower Grade Glioma_LGG_TCGA-DU-7007-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-69-8254-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-UB-AA0U-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.516331
endosome membrane	GO Cellular Component Annotations 2023	1.0	null
GSE210580_0_v_12_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X4XX-0008-SM-46MVK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17318
Primary T cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.925169
GSE213588_9_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LS1034	CCLE Cell Line Gene Expression Profiles	1.0	1.46085
BRD-A45889380_QUINACRINE HYDROCHLORIDE_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE184884_7_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
endosomal transport	GO Biological Process Annotations 2023	1.0	null
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.307554
Lung adenocarcinoma_LUAD_TCGA-86-7714-01A-12R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100478_HIP_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.30996
GSE100316_5_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TRIM28	ENCODE Transcription Factor Targets	1.0	null
GTEX-OHPN-2726-SM-2I5H4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952207
Organ system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
GTEX-WH7G-0008-SM-4LVNM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08727
Cytotoxic T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.045
SVEC4-10 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.583
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.496
PMC3507654-1755-8794-5-25-S4.pdf-0-ARID3B_ARID3B	Rummagene Transcription Factor Associations 2026	1.0	null
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2925_FAM50A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.875435
GSE242199_6_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SMMC-7721 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.514
15474998-tableS1b	GeneSigDB Published Gene Signatures	1.0	null
BA-19-VU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200175
BRD-K52130884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53308
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
CTCF_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
496100634_HIP_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.37939
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
18451145-TableS1	GeneSigDB Published Gene Signatures	1.0	null
cd4.Tcell	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.997077
validation	GeneRIF Biological Term Annotations	1.0	null
GSE206226_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.06456
BRD-K58853583_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7915-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-O5YT-0008-SM-4E3IQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884869
paclitaxel_homo sapiens_gpl570_gse39042	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100434_HIP_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.10429
BRD-K08316444_-666_SW620_6.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE108614,GSE108615_3_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Drug-Related Side Effects and Adverse Reactions	CTD Gene-Disease Associations	1.0	2.08681
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TAL1_01_217	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.97482
MET_knockout_252_GSE30651	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.34975
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-CO-1	GDSC Cell Line Gene Expression Profiles	1.0	1.61048
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.524716
NCIN87	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35155
Bile duct adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.266
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K54506283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20743
GSE231891_1_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K79090631_CGP-60474_HCC515_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
10558_ZNF695_ENST00000339986.7	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.560921
BRD-K15108141_gemcitabine_A375_24.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S4Q7-0008-SM-3NM8A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00002
NCI-H520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.841887
GSE202603_3_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCNA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00472291
CAPAN-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.773
6625_PPIE_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.61031
MSTO-211H cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.621
Translation initiation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.826
hematopoietic stem cell	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.572872
8431_SRSF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.755125
GA-47-MH68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.448756
TAL1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
blood plasma	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05096
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.01836
DLD-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
mood disorder	GWASdb SNP-Disease Associations	1.0	0.276501
imatinib_homo sapiens_gpl96_gds3045	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE112762,GSE112767_1_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE198380_0_v_1_phgdh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K38189757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3847
K562_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204749
GTEX-Q2AG-2926-SM-2HMJ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72993
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5462-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226770_1_v_6_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_HEPG2_48H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.26587
CRCGN016_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.54845
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9170821-JCMM-26-3183-s001.xlsx-Macro_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QXCU-0006-SM-2TC5K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56929
superior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0705
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.02262
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.862
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254996
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.844742
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K45612428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09146
azurophil granule	GO Cellular Component Annotations 2025	1.0	null
H3K4me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.91302
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE157777_1_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10543
hsa-miR-4699-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
cisplatin_homo sapiens_gpl570_gse15372	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE237040_2_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary motor-sensory cortex (samples)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.22774
GSE190186,GSE190188_8_v_5_apoe_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and neck cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.593
GSE151412_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Autoimmune disease of cardiovascular system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.032
Lung squamous cell carcinoma_LUSC_TCGA-60-2720-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.56872
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
primary auditory cortex (core)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.980681
GSE111102,GSE111105_4_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K44916315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26474
MCF7_Momelotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209169
GSE231720,GSE231724_2_v_1_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.35543
Cervix disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.356
BRD-K48406740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34601
8897_THTPA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.525543
hsa-miR-4478	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
GTEX-UJMC-0008-SM-4IHKK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03248
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908074
Perturb_15777_KO_Nmnat1_SRP360949	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.60117
GTEX-WYJK-1026-SM-3NM8W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2013
Sarcoma_SARC_TCGA-FX-A48G-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K9ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
18310505-TableS7	GeneSigDB Published Gene Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6793-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4P3-0426-SM-4AD56	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839585
endosome membrane	GO Cellular Component Annotations 2025	1.0	null
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.75937
GTEX-O5YV-0008-SM-4E3HP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990522
CRCGN014_HEPG2_3H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15382
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.08301
CA3 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.871229
GSE48812_8_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
BRD-A49544621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54699
GSE100316_7_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
vesicle	GO Cellular Component Annotations 2015	1.0	null
OF-98-RK57_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248755
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
prednisolone_homo sapiens_gpl570_gse32962	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KCI-MOH1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.29786
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
GTEX-PWN1-1626-SM-2S1OL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49757
Lung adenocarcinoma_LUAD_TCGA-05-5429-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Oral cavity cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.924
cklfsf18	GeneRIF Biological Term Annotations	1.0	null
GSE199543,GSE239447_0_v_4_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HDDC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10478
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WRHK-1626-SM-3MJFH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.064
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS6KA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00470337
K562_JQ1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119283
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
High grade glioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.645
hsa-miR-4727-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
OA-12-SU22_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299302
A549_Lomustine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155598
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7399
BHLHE40_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNF2	ENCODE Transcription Factor Targets	1.0	null
BRD-K53127431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20464
Kidney - Medulla	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.16553
Perturb_6826_KD_SAM68_SRP119826	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.59044
UE-90-AA63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223141
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.00598
Perturb_6381_KD_POU2AF1_SRP336261	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.57745
MYC	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE129725_1_v_5_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PWN1-0008-SM-48TEA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4187
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.2027
GSE123943_4_v_5_sox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K23984367_S1040_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
4941_MED19_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.584364
RYR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00543871
GSE154577_2_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Capecitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153181
K562_Celecoxib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180546
BRD-K39624517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18076
RT4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.874024
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
arteriosclerotic cardiovascular disease	GWASdb SNP-Disease Associations	1.0	0.668836
GSE84678,GSE93902_1_v_2_bcl11b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T6MN-0008-SM-4DM7H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48617
BRD-K25662647_FU_JMBII105B_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ROPN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00515233
IKBKG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00574997
GTEX-XUYS-0005-SM-47JZ2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28548
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
Stage, Non-Small Cell Lung Cancer	DisGeNET Gene-Disease Associations	1.0	null
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.376
EGR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Regorafenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143205
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.55004
PA-TU-8988S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13357
GSE149903_0_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K68548958_-666_A375_24.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventrolateral prefrontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03807
GTEX-N7MS-0011-R10A-SM-2HMJK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.972334
BRD-K82381502_miochol_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
8232_SNRPF_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.52607
GTEX-O5YT-1626-SM-32PK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1531
Mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WNT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540706
GTEX-V1D1-0008-SM-4JBIJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848648
Malignant Glioma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K64531971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14112
GSE190186,GSE190188_8_v_10_apoe_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CSTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36541
brain_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12377
2548_EIF3D_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.528157
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K45928581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08977
ABL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00341223
GTEX-RM2N-1626-SM-2TF5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07728
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-6_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.829627
GSE158834_10_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
JAK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67622
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-46-3766-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE241108_1_v_0_sulfasalazine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Antiphospholipid syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.079
GTEX-POMQ-0008-SM-48TE7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871457
hippocampus (hippocampal formation)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04269
GATA1_G1E-ER4_mm9_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE180200,GSE180201_2_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213228_2_v_3_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.039
GSE95688_7_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4776-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE180200,GSE180201_3_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Neural Tube Defects	CTD Gene-Disease Associations	1.0	1.47787
CCNT2	ENCODE Transcription Factor Targets	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LD-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Lenalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166839
BRD-K70771662_11K-629S_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC202	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-2.30252
AP3B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00684559
hsa-miR-4308	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
APH1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00502909
16488994-SuppTable1b	GeneSigDB Published Gene Signatures	1.0	null
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92356128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7738
ARID3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08719
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H1_Derived_Mesenchymal_Stem_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.13703
Nr2e1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.9387
Muscular Diseases	CTD Gene-Disease Associations	1.0	1.27193
FOXC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9733
Perturb_1332_KD_OGT_SRP370878	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.4506
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Gastric adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.348
GSE210101,GSE210114_6_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE137144_4_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SW1271	CCLE Cell Line Gene CNV Profiles	1.0	1.39871
GSE107956,GSE107957_0_v_1_ythdf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239688_4_v_0_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lymphoid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.097
SLC25A15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19891
BRD-K93884191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21794
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETV4_ETV4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Memory Disorders	CTD Gene-Disease Associations	1.0	1.34926
GSE57871_6_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242096,GSE242098_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OHPN-0008-SM-4E3HW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900607
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SN-01A-12R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE110178_2_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AU565	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.966911
Dendritic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.852
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.13211
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.42878
ROS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00565876
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X8HC-2726-SM-46MUA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19455
ETS1	ENCODE Transcription Factor Targets	1.0	null
PMC5031867-mmc2.xlsx-RYTTCCTG_V_ETS2_B-PROBE_ETS2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE140651,GSE140653_2_v_7_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.90818
mononuclear phagocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE160817_5_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Rh	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.504
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BMF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00829425
SYK_KD_GDS3609_441_human_MCF10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
VMRCLCD	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54532
GSE241701_4_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37392901_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NBPF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76244
Liver Failure	CTD Gene-Disease Associations	1.0	1.05423
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE200352_5_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K42455540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23575
A549_Mocetinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122959
GTEX-RM2N-0008-SM-48FF3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98929
Lung adenocarcinoma_LUAD_TCGA-55-7815-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.051
10400_ZNF497_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.864164
GTEX-PLZ6-0008-SM-48TD5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20153
MUTZ8	DepMap CRISPR Gene Dependency	1.0	2.76756
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MHHES1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54768
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.549339
HNF1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00559829
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05226
Perturb_12308_KD_CDK12_SRP073459	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.0485
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_4316_KO_Ror2_SRP292420	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.99499
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.926996
MAX	ENCODE Transcription Factor Targets	1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.045088
GSE130383_1_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X4XX-0011-R3B-SM-46MWK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989535
GSE230573_1_v_0_dcaf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039007
colo679	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.253
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U8T8-0008-SM-4DXSP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40702
male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K51454545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07576
GSE226770_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
Trunk	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.83399
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A56592690_PX12_PL21_6.0_h_30.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Specific granule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K62459624_T5212475_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
P2RY10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00726496
GSE244518,GSE244520_1_v_0_dnmt3b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H2722	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.841745
globus pallidus, internal segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07467
CRCGN015_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.1732
GSE196117_1_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4477b	TargetScan Predicted Conserved microRNA Targets	1.0	0.181316
CHL1DM	DepMap CRISPR Gene Dependency	1.0	2.95128
FOXA1-25552417-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Uterine disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.437
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.58665
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.337754
A549_Aurora A Inhibitor I_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172986
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.97044
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNOS-0526-SM-4DM54	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22293
PPIB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00407874
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
semen	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.2723
Uveal melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.29317
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1A5-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AA-54-WG39_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288871
BRD-A86415025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12787
GSE199606_2_v_7_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K56196992_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HRH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00625386
GSE130081,GSE130082_5_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RORC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00506168
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
supraoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17387
CCR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00679361
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63625
hsa-miR-1280	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GSE171724_4_v_5_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TCFAP2C-20176728-TROPHOBLAST-STEM-CELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE210101,GSE210114_2_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140322_3_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HEK 293 T-rex    	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.08881
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.994478
JHESOAD1	CCLE Cell Line Gene Expression Profiles	1.0	1.36337
GTEX-RU72-0011-R2A-SM-2TF6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.0894
VZ in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.928531
CL-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.33874
GTEX-U412-0326-SM-3DB9L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7711
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.949117
KEAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00783548
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.648985
PMC8851354-Table_6.xlsx-STAT3-bound_genes_GM12878-Supplementary_Table_6_STAT3-bound_unique_genes_in_GM12878_cells_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
Substance Withdrawal Syndrome	CTD Gene-Disease Associations	1.0	1.13655
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.99216
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A95207036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36539
PMC9564215-pnas.2203480119.sd02.xlsx-OVCAR-5_SCD_KD_cultured_in_low-hgnc_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K56ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K11022796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05475
Myelin membrane	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.613
ANKRD50	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00586609
HS 578T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.902537
GSE148252_1_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119603_1_v_0_oxaliplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.76218
BRD-K84761515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23123
GTEX-XOTO-3026-SM-4B65M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09016
GABPB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00585108
STAT3-1855785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE157555,GSE157556_4_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941938
estradiol_homo sapiens_gpl570_gds3217	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_MCF10A_48H:A08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29202
Head and neck cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.925
GTEX-WEY5-0008-SM-4LMKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37035
CRCGN010_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.34202
PMC12685885-Table1.xlsx-Table_S9-Du_PanCancer_SOX6_TrsFib_SOX6	Rummagene Transcription Factor Associations 2026	1.0	null
CA3 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04983
GTEX-R3RS-0526-SM-3GADG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980906
GTEX-OHPN-0011-R11A-SM-2I5FM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832097
GTEX-RVPV-0008-SM-47JYW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28125
BRD-K77677632_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-U4B1-1626-SM-3DB8N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28012
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.711303
SARS-CoV_72Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.63458
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-QB-A6FS-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE224311_3_v_1_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
KAT2A	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN014_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.31912
GSE117042_1_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Secretory granule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Blood platelet	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
rosiglitazone_homo sapiens_gpl570_gds2453	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952791
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.01548
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K32787834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45716
COR-L311	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.79514
PMC9145061__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE140322_3_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE237040_0_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.06768
Type 2 diabetes mellitus_Renal Tissue_GSE642	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.0298
Perturb_13664_KD_WIPI1_SRP299893	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Bile duct disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE180200,GSE180201_5_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CBX3	ENCODE Transcription Factor Targets	1.0	null
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49146
PDE9A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00666978
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PC-87-OG75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236634
MEG01	CCLE Cell Line Gene Expression Profiles	-1.0	-2.37108
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.15157
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.79126
Brain - Anterior cingulate cortex (BA24)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.74443
SARS-BatSRBD_48Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.3299
EGR1-23403033-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE166920_6_v_2_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.33938
GTEX-T8EM-1026-SM-3DB7M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03006
GSE200352_1_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE196117_6_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ovarian mucinous adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.076
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Tachycardia, Ventricular	CTD Gene-Disease Associations	1.0	1.17134
BRD-K15444511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9404
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
ZNF423	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02657
Conventional (Clear Cell) Renal Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE180200,GSE180201_3_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE154767_1_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23907
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.81035
Calu-3	GDSC Cell Line Gene Expression Profiles	1.0	1.45294
GSE88819_0_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K21662756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75326
GTEX-PLZ5-0626-SM-2I5F8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02574
MEF2A	ENCODE Transcription Factor Targets	1.0	null
BRD-K20284960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22899
Recycling endosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
HSF1_KD_GDS1733_751_human_HeLa cells - 0.5 Hour by siHSF1_1	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
A549_SRT3025 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222259
2784_EXOC7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.578367
based	GeneRIF Biological Term Annotations	1.0	null
STAT5A	ChEA Transcription Factor Targets	1.0	null
GTEX-PLZ4-0008-SM-48TE6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846946
Brain Diseases	CTD Gene-Disease Associations	1.0	1.43293
VI	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.982468
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8514
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFON-2326-SM-3LK7M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46031
CRCGN015_MCF10A.WT.HP_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10475
5748_NOP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.554954
CRCGN017_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9022
Lung squamous cell carcinoma_LUSC_TCGA-56-A5DR-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K97086564	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55354
Mesothelioma_MESO_TCGA-LK-A4O0-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-DX-A1L1-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE218580_1_v_2_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
deep layers of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05342
HNF4A	ENCODE Transcription Factor Targets	1.0	null
depression	GWASdb SNP-Phenotype Associations	1.0	0.749042
GSE180200,GSE180201_3_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE122378_0_v_1_carmil3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S341-1826-SM-3K2AB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09864
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.875378
GSE69869_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Ramelteon_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160122
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE214514_1_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE180200,GSE180201_12_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_11338_KD_Ankrd35_SRP214047	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
DLD-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12484
GSE171837_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-489	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GSE144838_7_v_5_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5848610-supp_gr.228809.117_Supplemental_Table_S3.xlsx-Table_S3F-Supplemental_Table_S3F_ZFX_binding_pattern_clustering_information_for_genes_with_promoters_bound_by_ZFX_related_to_Figure_2I_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4777381-pone.0150624.s007.xlsx-dif_exp_AD-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.615
SKCO1	CCLE Cell Line Gene Expression Profiles	1.0	1.38182
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.86255
GSE178714_5_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TX-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11634
PMC7397849-supp_gad.338681.120_Supplemental_Table_S2.xlsx-S2B_in_vivo_shared-Suppl_Table_S2B_shared_genes_between_RCAS-YAP1-MAMLD1-dR3R1_RCAS-YAP1-FAM118B_RCAS-YAP1-TFE3_in_vivo_tumors_RCAS_mouse_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K43282617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1954
Perturb_3473_KO_Cox6a2_ERP114839	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.41314
posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.924186
pparb_23093780_pancreas_lof_mouse_gpl1261_gds4320	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.038396
GSE199899_4_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE180200,GSE180201_5_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-58-FJ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.383056
GSE179880_10_v_3_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RTLS-0008-SM-48FET	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28824
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895764
Perturb_9117_KD_EZH2_SRP061380	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.0746
BRD-K58944125	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15296
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GRHL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00761504
Foxj3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	44.8182
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.344037
FOXA2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
GSE210101,GSE210114_1_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.0507
PMC8318642__F3	PFOCR Pathway Figure Associations 2024	1.0	null
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE216273,GSE216292_14_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BT-474	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.24687
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.29354
Perturb_8040_KO_SHMT2_SRP390421	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.9833
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35788
GSE149139_1_v_0_carm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE136742,GSE136744_2_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-8_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
SK-N-DZ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.40049
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.26337
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263875
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ED-43-XF39_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.427583
BRD-K57472585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07054
GSE228894_0_v_1_rnmt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XUYS-0008-SM-47JYZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2147
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.41014
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC6683136-41598_2019_47363_MOESM4_ESM.xlsx-GENE_SET-Positive_correlation_of_ZEB1_and_other_genes_ZEB1	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-8165-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_8838_OE_MLLAF4_SRP293797	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.61929
BRD-K20906316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14138
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSB-1826-SM-3TW8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65454
GTEX-U3ZN-0008-SM-4DXTL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56898
GSE142684_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SLC25A23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23327
SNU1214	CCLE Cell Line Gene CNV Profiles	-1.0	-1.5211
Perturb_238_KO_ARID2_SRP315504	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.51471
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.349925
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-QV31-1426-SM-2S1QD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.982143
CUX1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HMGN3	ENCODE Transcription Factor Targets	1.0	null
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K46171140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15371
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.856
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SYK_druginhibition_288_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.15738
GSE158182_5_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
6801_PRPF4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.541547
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
endocytic recycling	GO Biological Process Annotations 2025	1.0	null
RBM6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0041724
sirolimus_homo sapiens_gpl2895_gse16944	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04029
behavioral abnormality	GWASdb SNP-Phenotype Associations	1.0	0.234822
GTEX-QVUS-0008-SM-447AY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884729
PMC11474056-pnas.2404841121.sd01.xlsx-Supplemental_Table_8_Fig1G-H-Supplemental_Table_8_Transcriptomic_overlap_between_LPS_and_Sepsis_and_or_Tuberculosis_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Cleft Lip	CTD Gene-Disease Associations	1.0	1.01852
GSE158834_10_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
orbital frontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.981282
MCL1	MSigDB Cancer Gene Co-expression Modules	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2M1-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05876
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-OXRN-1326-SM-3LK5V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22601
BRD-K94025757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03624
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.23226
Lung adenocarcinoma_LUAD_TCGA-44-3398-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HUPT4	CCLE Cell Line Gene CNV Profiles	1.0	1.8809
BRD-K74148702_curcumin_MCF7_6.0_h_48.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Brain Lower Grade Glioma_LGG_TCGA-HT-8110-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K03370561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00972
hsa-miR-26b-5p	MiRTarBase microRNA Targets	1.0	null
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZM-0008-SM-4DXTQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38573
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99094
CTCF_fibroblast of mammary gland_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
appendices_4b	HPA Tissue Sample Gene Expression Profiles	1.0	0.87277
BRD-K60216304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18303
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.57121
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.057896
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.56441
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44223
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K36me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE139348,GSE139349_1_v_0_dicer1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CL14	CCLE Cell Line Gene Expression Profiles	1.0	1.44551
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TFAP2C	ChEA Transcription Factor Targets	1.0	null
BRD-A93942655_NCGC00188535-01_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC9886955-41420_2023_1325_MOESM12_ESM.xlsx-H6_14AvsH6_NC-Unnamed_2_HMX1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AD-43-XJ59_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235056
Caov-4	GDSC Cell Line Gene Expression Profiles	1.0	1.64418
GSE103068_5_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A45889380_QUINACRINE HYDROCHLORIDE_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE211262,GSE211263_2_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH810	CCLE Cell Line Gene CNV Profiles	-1.0	-2.31749
4956_MED6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.588396
internal female genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
BRD-K85606544_HKI-272_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NFIC_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00632987
GTEX-OHPK-0326-SM-2HMJO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952512
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.61213
AA-67-TF79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.329615
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7250-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K31801624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19312
Perturb_1159_KD_CELSR2_SRP149837	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.57036
GSE158197_0_v_11_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K23064726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18313
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Unnamed_13_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5517-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE208254_3_v_1_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE254649_2_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
frontal pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.917131
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-11A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
dorsalstriatum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.91898
GSE114013,GSE114014_0_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2916-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
20418243-SuppTable1a	GeneSigDB Published Gene Signatures	1.0	null
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828018
BRD-K14875480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.62993
4940_MED18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.0842
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7068-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XBEW-0008-SM-4AT3Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52758
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A3IE-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ethanol_homo sapiens_gpl96_gds2767	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2709-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12437
POU3F1-26484290-ESCSS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0719
GTEX-NL4W-0008-SM-4E3I2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07378
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.97889
Integumentary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
GSE224096_1_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GE-77-FY84_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20208
PMC3677161__F5	PFOCR Pathway Figure Associations 2023	1.0	null
hsa-miR-944	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050838
CRCGN017_MCF10A.WT.HP_24H:D02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15999
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K57732605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25502
CTSE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00445556
H3K4me1_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
5900_NUP62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.732776
NCI-H2373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16914
GSE185519_4_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
icSARS CoV_72Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.72855
BT474	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.54186
GSE243491_1_v_2_oxaliplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K34737616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08129
inherited metabolic disorder	GWASdb SNP-Disease Associations	1.0	0.29144
ATF4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00728538
STAT4	ChEA Transcription Factor Targets	1.0	null
GTEX-XBED-0008-SM-47JWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28791
BRD-A77216878_manumycin A_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XUYS-0126-SM-47JWZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01309
TCF4-18268006-LS174T-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Kidney Tubular Necrosis, Acute	CTD Gene-Disease Associations	1.0	1.12668
GTEX-OOBJ-0326-SM-33HBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11816
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.837872
RCOR1	ENCODE Transcription Factor Targets	1.0	null
GTEX-WYJK-0005-SM-3NMA1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07565
GSE122711_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PML_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.869146
SH4	DepMap CRISPR Gene Dependency	1.0	3.8262
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.323043
anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23504
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.01787
BRD-K31748787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1426
GSE178340_1_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE248045,GSE248046_0_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE149442_1_v_0_gdpd3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
9831_WDR5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.505058
GSE229973_4_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE224969,GSE224971_0_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
B-lymphoblastoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.424
Dizziness	CTD Gene-Disease Associations	1.0	1.25183
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUO-01A-12R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and neck squamous cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.605
CEBPB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cytotoxic T-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.768
BRD-A09164687_1495-0136_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE95685_2_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE166914_1_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
L428	CCLE Cell Line Gene Expression Profiles	1.0	1.72142
BRD-K34363290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28194
GSE135514_2_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NTRK2_drugactivation_66_GSE20358	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	3.42693
SNU-387	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.86864
GTEX-NFK9-0008-SM-4E3JE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24322
TTLL8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71929
NCI-H2405	GDSC Cell Line Gene Expression Profiles	1.0	1.43527
BRD-K57688676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11351
RA-49-ZB08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202463
ERF::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.7106
adult stem cell	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.572872
GTEX-V1D1-2426-SM-3GAER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45013
GSE213228_2_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF451	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28641
RPS20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51368
GSE165334_3_v_0_dabrafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QCQG-2126-SM-2S1P8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32995
Integument	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Pancreatic carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.544
BRD-K45272675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06172
BRD-A67788537_Salermide_A375_24.0_h_120.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Bladder disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.411
BRD-K53752646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6844
homeostasis/metabolism phenotype	MPO Gene-Phenotype Associations	1.0	null
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EPRS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00639461
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE154767_4_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3827940-2045-3329-3-12-S1.docx-1-Supplementary_Table_2_Minor_allele_frequencies_MAF_and_p-values_for_comparison_of_genotype_frequencies_Z9001_genotyped_whites_n_273_versus_non-whites_n_58_1_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCIH1385	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54656
Type 1 diabetes mellitus_Thymic epithelial cell_GSE11	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.24226
Serum Total Cholesterol Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
6927_PTPN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.734658
CRCGN008_HEPG2_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12145
mRNA_POU5F1_16767105	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-PSDG-0008-SM-48TE5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11533
GSE225684_0_v_2_tfap4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Edema	CTD Gene-Disease Associations	1.0	1.6538
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.93971
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE173232_1_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cervix carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
VB-48-KG22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203475
GSE110178_5_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-98	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
GSE144500_8_v_2_ventx_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K19662956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50105
GSE57871_11_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
MS (Multiple Sclerosis)_CNS - Spinal Cord (MMHCC)_GSE842	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.73485
PMC11061611-cd-23-0857_table_s4_suppst4.xlsx-Myeloid_F2-pM2_FU2_unique_LEF1_LEF1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:C12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21155
sevoflurane_homo sapiens_gpl570_gds2772	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_14783_KO_Mof_SRP225948	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.81693
CKAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04979
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05651
496100374_HIP_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00565
GSE219103,GSE219104_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
XE-18-BC97_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.748295
Perturb_11611_KD_BRD8_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.75576
SUDHL5	DepMap CRISPR Gene Dependency	1.0	13.4633
GSE221327_10_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.53982
GSE207914_3_v_6_nudt7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135030_11_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GTEX-RWS6-0326-SM-2XCAP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.994046
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ppard_23093780_pancreatic_beta_cells_lof_mouse_gpl1261_gds4320	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.038396
Perturb_11662_KD_PPP1CB_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.23303
GTEX-QVUS-0011-R4A-SM-3GAE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848986
BRD-K60623809_SU11652_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-4263	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.0765
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.975928
Lhx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	67.95
Perturb_12186_KD_TP53_SRP065500	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.48497
Mucosal melanoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.553
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01994
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21671
GSE166004_7_v_0_pld1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K95385525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44932
anterior (rostral) cingulate (medial prefrontal) cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06605
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXM1	ENCODE Transcription Factor Targets	1.0	null
GSE221327_1_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE185519_3_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
amygdaloid complex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.980014
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4395-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K53889798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.30092
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34493
GSE155972_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A79465854_auranofin_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
OBSCN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00525658
GTEX-N7MS-1626-SM-3LK5F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16332
GTEX-N7MT-0011-R6a-SM-2I3G3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24226
SCRT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8008
GTEX-OXRL-1626-SM-2YUMU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15897
HCC33	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.51284
Cervical squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K01717817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23588
GSE206784_3_v_4_ninl_human	RummaGEO Gene Perturbation Signatures	1.0	null
CFPAC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.634
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CREB1	ChEA Transcription Factor Targets	1.0	null
GSE44157,GSE44163_3_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.9745
BRD-K76674262_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11947
TP53-23651856-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q734-0008-SM-48U2I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00658
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE166317_3_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A85860691_chaetocin_MDST8_6.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Serum Ldl Cholesterol Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K72745710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.6289
Bronchial epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.363
Adrenal gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.035
GSE196117_1_v_11_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-PVOW-2526-SM-2XCF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49368
Perturb_1321_KD_VIRF3_SRP201368	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.94977
7842_SFPQ_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.554078
GSE203181_0_v_1_phosphoramidon_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prenatal Injuries	CTD Gene-Disease Associations	1.0	1.32756
FOXM1-26100407-CHIP-SEQ-HEK293-FLP-IN-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GNGT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00581499
outer CP in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23534
GSE192860_0_v_1_trifluoperazine_human	RummaGEO Drug Perturbation Signatures	1.0	null
DC-43-KF54_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248513
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2409
Anemia	CTD Gene-Disease Associations	1.0	1.22948
CHRNA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00499154
GSE167886_2_v_1_chd7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE172490_0_v_1_junb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.61051
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847936
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE216043_10_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K70237115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27774
GSE217115_2_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02898
Epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.363
HSFY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47263
PMC7657020__F3	PFOCR Pathway Figure Associations 2023	1.0	null
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:B15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00092
GTEX-RTLS-0526-SM-2TF64	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45784
ETS1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE134191_3_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Brain_Germinal_Matrix	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.4778
UF-14-LK87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260422
1976_CWF19L2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.641323
skin	GTEx Tissue Gene Expression Profiles	1.0	1.17887
GRANTA-519	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31134
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AB-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4677-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.91301
BRD-K42899345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02969
A549_Cerdulatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0108744
CRCGN017_MCF10A.WT.HP_24H:K22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.36745
CTCF_retinal pigment epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredPeptides-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.615354
BRD-K69349031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10314
esrra_19901197_kidney_lof_mouse_gpl1261_gse16623	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.09487
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.47332
hsa-miR-4801	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE208634_1_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.176
GSE201270,GSE201272_0_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-VUSH-0008-SM-47JWK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3919
extracellular vesicular exosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K25573760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72875
GSE98898_7_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.312
7827_SET_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.688619
U2904	DepMap CRISPR Gene Dependency	1.0	2.04239
NCIH1436	CCLE Cell Line Gene CNV Profiles	-1.0	-1.56901
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.931131
azurophil granule membrane	GO Cellular Component Annotations 2023	1.0	null
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.6296
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.344633
BRD-K84052780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21167
GTEX-XUZC-2126-SM-4BRW8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43064
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.97044
BRD-K57365604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50953
GSE182680,GSE182683_10_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	1.0	2.18724
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9354
marrow cell	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE145249_1_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H2171	GDSC Cell Line Gene Expression Profiles	-1.0	-1.88729
GTEX-WY7C-2526-SM-3NB2N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24683
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.777917
GTEX-X5EB-0008-SM-46MU3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04081
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.88836
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.527547
ChIP_ASH2L_23239880	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
sulfanitran	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35111
LU-135	GDSC Cell Line Gene Expression Profiles	-1.0	-1.9888
decreased circulating bilirubin level	MPO Gene-Phenotype Associations	1.0	null
MCF7_PFI-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017707
SUMO2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K05804044_HY-11004_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Diethylnitrosamine	CTD Gene-Chemical Interactions	1.0	null
GTEX-R55F-0011-R6A-SM-2TF4L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.35516
Lung adenocarcinoma_LUAD_TCGA-49-4488-01A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.62736
CDH3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00416939
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE165334_3_v_1_dabrafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-5234-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Resveratrol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153677
BRD-K47582411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09866
integument	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
MCF7_JNJ-26854165_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150409
2707_ERH_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.775941
GTEX-T5JW-1826-SM-3GAE1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60439
GTEX-OXRN-0126-SM-48TDM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863918
HT55	GDSC Cell Line Gene Expression Profiles	1.0	2.05253
Brain - Cerebellar Hemisphere	GTEx Tissue Gene Expression Profiles 2023	1.0	1.92273
GSE218356_1_v_0_cited1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Uterine carcinosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.837
MOCS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37151
FOXO3-22982991-MACROPHAGES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K54687541_3-isobutyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO 206F	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.964359
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.625136
FTC-133 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.531
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.89002
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.039
MTA3	ENCODE Transcription Factor Targets	1.0	null
GSE151090_2_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Renal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.663
GSE120595_0_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125782_0_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149977
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19504
SOX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8757
GSE146982_0_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11531655-MCO2-5-e754-s001.docx-0-IRF7_Regulon_2_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14147
DMS454	CCLE Cell Line Gene CNV Profiles	-1.0	-2.59343
PMC11551467-pnas.2414963121.sapp.pdf-10-ZNF76_ZNF76	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_CH12.LX_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QV44-0008-SM-447AX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.984139
BRD-K02190643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57539
GTEX-N7MS-0426-SM-2YUN6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50309
KYO1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.07839
K562_Linifanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162234
STAT5A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.26585
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17660535-TableS4a	GeneSigDB Published Gene Signatures	1.0	null
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5377
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.779
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.03936
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5989-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
18818702-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
A549_Rucaparib_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.011404
MCF7_Ivosidenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191583
OCIAML2	DepMap CRISPR Gene Dependency	1.0	3.28739
H3K27ac_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16237
GSE172295_1_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RU72-0011-R6A-SM-2TF71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836367
GATA1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_KLF4_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
clone15c4	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.582
FOXA1_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hmc1	HPA Cell Line Gene Expression Profiles	1.0	1.01663
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_2287_KD_XPO6_SRP245599	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.04163
FLI1	ChEA Transcription Factor Targets	1.0	null
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9RL-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6792
BRD-A90462498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36534
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23152
1716_CNOT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.83973
19204204-SupplementaryTable1	GeneSigDB Published Gene Signatures	1.0	null
BRD-K39185798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.636
frontal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.23879
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
BRD-K14216332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27015
PMC3669416-pone.0064838.s001.xls-mHTT-AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAL1_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K13566078_BMS-345541_HME1_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CBX3_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCT-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE199899_1_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K61912055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08351
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.41794
JMSU1_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	4.05128
pontine nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.27154
GSE200352_4_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SKNO1	DepMap CRISPR Gene Dependency	1.0	2.55898
GSE237040_0_v_5_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
NFIC	ENCODE Transcription Factor Targets	1.0	null
TEK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00622766
BDH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00406027
GSE219195_1_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U3ZN-1726-SM-4DXUQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927771
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RCOR1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217452_3_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013639
8651_TAF10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.593752
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.1263
IA-27-CK10_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290723
SARS-CoV_84Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.6982
NCI-H2228	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12585
Prostate adenocarcinoma_PRAD_TCGA-EJ-5522-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84635
UBTF	ENCODE Transcription Factor Targets	1.0	null
BRD-A60513937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20516
CTCF_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18149487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95598
BRD-K75985122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00678
GABPA_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A00420644_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-NPJ8-2226-SM-3TW8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56572
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.395754
RUNX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00604663
A549_AZ 960_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127464
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.37728
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PELI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564163
GSE86507,GSE86509_0_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	2.30123
GSE146982_7_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.82442
GSE135514_8_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K83336168_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NR2F2	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-4279	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Secretory granule membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
cytosol	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Lung adenocarcinoma_LUAD_TCGA-05-5428-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4777381-pone.0150624.s006.xlsx-dif_exp_AD-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
GSE145445,GSE145454_0_v_1_cop1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	1.0	2.26076
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.50363
primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02816
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.89324
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4795-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Pain	CTD Gene-Disease Associations	1.0	1.10838
HT-55	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.11241
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2858_FAM136A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.564378
GSE133087_5_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSTO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0059034
GSE120370_0_v_6_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A-498 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.62
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.414152
abnormal blood homeostasis	MPO Gene-Phenotype Associations	1.0	null
lipid metabolism disorder	GWASdb SNP-Disease Associations	1.0	1.39396
GSE146982_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
bone marrow cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QV31-0008-SM-447AT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09192
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.10033
JUN	ENCODE Transcription Factor Targets	1.0	null
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C80	DepMap CRISPR Gene Dependency	1.0	4.68186
GTEX-SJXC-0008-SM-4DM7G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08178
PMC11976269-41375_2025_2519_MOESM3_ESM.xlsx-ChIP_GATA2_Cluster_B-GeneName_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_UNC1999_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177288
H3K27ac_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.513
Cardiovascular Diseases	CTD Gene-Disease Associations	1.0	1.63631
hsa-miR-4795-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
BRD-K19310540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44996
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.35748
GSE217776,GSE217829_2_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K20655524_MEFEXAMIDE_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
outer CP in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28674
BMS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27019
Perturb_16792_KD_SPIB_SRP124308	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.05532
Prostate adenocarcinoma_PRAD_TCGA-CH-5788-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FUOV1	CCLE Cell Line Gene CNV Profiles	1.0	2.2843
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PU.1-20513432-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KML1	DepMap CRISPR Gene Dependency	1.0	3.11732
hsa-miR-451	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SBDS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00660857
GSE125219,GSE125221_4_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
vesicle-mediated transport to the plasma membrane	GO Biological Process Annotations 2023	1.0	null
SETDB1	ChEA Transcription Factor Targets	1.0	null
GSE236003_0_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
chr3_32480896_G_A_b38	GTEx eQTL 2025	1.0	1.14944
4598_LIN9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.59029
Biliary tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
BRD-K69241192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04812
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80055
Brain Lower Grade Glioma_LGG_TCGA-DU-8158-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6022-01A-21R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_epithelial cell of esophagus_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.65841
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.28353
hsa-miR-3065-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.082179
Prostate adenocarcinoma_PRAD_TCGA-EJ-5514-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE220520_3_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.388
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.316884
amygdaloid complex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.27186
MCF7_Resminostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00975124
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5557-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZH-0008-SM-4DXT2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14263
GTEX-RU72-0011-R7A-SM-2TF5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.878791
XC-65-XN91_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251304
GSE227891_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Uterine corpus cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.325
GSE214442_0_v_1_pak4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H4K8ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.467
imatinib_homo sapiens_gpl571_gds3518	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE215086_8_v_7_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
extracellular region part	GO Cellular Component Annotations 2015	1.0	null
GSE211177,GSE211178_9_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10266
GSE148263_6_v_0_trim3_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3111
uterine cervix	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.219264
PMC12375500-41388_2025_3449_MOESM1_ESM.xlsx-DBP_up-gene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
families	GeneRIF Biological Term Annotations	1.0	null
GTEX-WL46-0011-R10A-SM-3MJFQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04245
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.30746
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-PAX6_UNIQUE_DYS_GENES-PAX6_TLE_vs_TL_log2FoldChange_1_padj_0_1_PAX6	Rummagene Transcription Factor Associations 2026	1.0	null
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K60759770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2971
Leukemia, Chronic T-Cell_T lymphocyte_GSE5788	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.8001
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.67811
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.890668
hsa-miR-4483	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
PMC4580625-pone.0138726.s006.xlsx-Immune_molecular_modules-ZBTB7B_mod_ZBTB7B	Rummagene Transcription Factor Associations 2026	1.0	null
specific granule	GO Cellular Component Annotations 2025	1.0	null
GSE88819_3_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4688-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN011_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0205
GTEX-U412-0008-SM-4DXTE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69917
ARPC5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00546342
REPIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07657
CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16016
uterus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE216043_10_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K18978916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61826
GC-86-TD91_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225569
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.573
RPP38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17737
GSE180200,GSE180201_15_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-1260	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
inferior frontal gyrus, triangular part, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.873396
GTEX-S7SF-0008-SM-3NM8T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26371
FOXA1_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Oligodendroglioma_CNS - Brain (MMHCC)_GSE2223	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.27282
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
9747_VPS28_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01702
5163_MPHOSPH10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.556901
8820_TERF2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.777031
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Combined-MYB_Combined_sgRNA_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.872077
SW 780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.908464
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
7833_SF3A2_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.747334
GSE157383_3_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UTHO-3026-SM-3GAFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47665
5016_MFAP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.803963
Caudatenucleus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.911495
Perturb_701_KO_TET2_SRP200817	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.94818
hsa-miR-4513	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81061
PMC7606598-NIHMS1624889-supplement-1624889_Supp_Tab1-10.xlsx-S8_MR-JTI-genename_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K41133627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16179
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
S0-EE-WJKI_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.424239
BRD-K46739745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02993
CEBPD_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	-1.0	null
pharynx cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.120659
HPAF-II	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.902537
GSE76771_2_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.919984
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K78009480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38028
Liver	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.06726
GSE158834_11_v_5_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	1.0	2.3792
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	98.7315
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3MV-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterine Cervical Neoplasms	CTD Gene-Disease Associations	1.0	1.13929
BRD-K82521339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08627
CL-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.3721
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7406-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE48812_7_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210580_4_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7375
BRD-A86748098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31176
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-1_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_4_FDC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
4271_KANSL2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.662628
BRD-K08799216_pelitinib_A549_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
WholeBlood	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.10839
PANC0213	CCLE Cell Line Gene Expression Profiles	1.0	1.96764
BRD-K57786075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63187
Left_Ventricle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.931936
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CEBPB_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1606_KO_Tnfaip3_SRP056432	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.68245
TAL1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.01645
BRD-K12864860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20395
Parenchyma	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.045
MAZ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	83.4761
Perturb_1160_KD_CELSR2_SRP149837	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
NCIH524	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55284
BRD-K28120222_Prestw-550_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.541
GSE207611,GSE207612_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TCF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4232
SYK_knockdown_191_GSE54065	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.51128
A549_UNC0379_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174208
SETDB1-19884257-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K55286508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54861
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5151-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-SI-A71P-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE224294_3_v_2_ngly1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FD-20-OG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.362006
BRD-K24132293_piperlongumine (HPLC)_NCIH1694_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Innate Immune System	Reactome Pathways 2024	1.0	null
Oral squamous cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.169
membrane-bounded vesicle	GO Cellular Component Annotations 2015	1.0	null
TAL1	ENCODE Transcription Factor Targets	1.0	null
SW 837	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05062
E2F1	ChEA Transcription Factor Targets	1.0	null
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.34847
BRD-K17659275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00026
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.16159
CHAGOK1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50212
6460_PLRG1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.643497
BRD-K27476975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11806
BRD-K33752391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43316
SKNBE2	CCLE Cell Line Gene Expression Profiles	-1.0	-2.06188
GSE92589_0_v_1_sirolimus_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K78599730_manumycin A_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K16276539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09884
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
BRD-K58112932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06062
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039416
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15158
4220_ITFG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.885567
Barrett Esophagus_Esophageal Tissue_GSE1420	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.41176
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXO3-23340844-DLD1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.78954
VZ in subgenual cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.932342
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A551-01A-21R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
trovafloxacin_homo sapiens_gpl96_gse9166	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.420235
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K05432466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16764
GTEX-XUJ4-0008-SM-4BOQI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14491
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6938-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7382-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin - Not Sun Exposed (Suprapubic)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.21089
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7496
gracile nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01741
Down Syndrome_CNS - Brain - Cerebellum (MMHCC)_GSE1611	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.62462
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RAD21_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
CD56+_NKCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.870665
blood	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-Q2AG-0426-SM-2S1PU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.03487
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL4W-0011-R11A-SM-2I3DW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.33876
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114013,GSE114014_0_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC70	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.754836
Neoplasms	CTD Gene-Disease Associations	1.0	1.49558
HS746T	CCLE Cell Line Gene CNV Profiles	1.0	3.24479
NCI-H2228	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.899382
extracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
LEF1-29337183-MESC-MOUSE-STEM	ChEA Transcription Factor Targets 2022	1.0	null
t66-lung_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.8892
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SP5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.6825
GSE120413,GSE120447_0_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_9702_KO_Mef2a_ERP122655	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-18.0969
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251284
Perturb_12000_KD_SPI1_SRP090090	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE208254_3_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HDLM-2	GDSC Cell Line Gene Expression Profiles	1.0	2.93258
496100453_HIP_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.24716
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K53308623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17463
Perturb_643_KD_FASTKD1_SRP299834	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.063
Ebolavirus(EBOV)_5day_PBMCs_17725815_GSE8317	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.12067
fallopiantube_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.52496
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.159
GSE112763,GSE112767_0_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE207282_1_v_0_polydatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE110178_4_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.67042
PAX5	ENCODE Transcription Factor Targets	1.0	null
GSE182727_1_v_0_busulfan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
6549_POLR2H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.53119
Learning Disorders	CTD Gene-Disease Associations	1.0	1.55035
GSE155305_3_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_3_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_SRT3025 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172877
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2203_DHX15_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.697871
HDLM2	CCLE Cell Line Gene Expression Profiles	1.0	2.89562
GSE101239_4_v_2_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CEBPB_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_10_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_12702_OE_ERG/FLI1_SRP397680	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-14.9297
NCIH211	DepMap CRISPR Gene Dependency	1.0	8.97143
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.427671
BRD-A57536034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56099
GSE215086_1_v_6_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
cyclophosphamide_mus musculus_gpl13209_gds4003	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S3XE-1226-SM-4AD4L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919652
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE215086_0_v_1_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K06792661_Narciclasine_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
CRCGN016_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5424
GSE146840,GSE146842_3_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.265
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
8431_SRSF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.792297
hsa-miR-3913-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GTEX-RWS6-0008-SM-47JYV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61095
BRD-K50081142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14418
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PK-59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.840512
GSE184902_3_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.209
HNF4G_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WB-54-WD35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280441
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.900474
HB-92-XE24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.481475
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228191
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KLF4-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ZR-75-30 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.616
amygdaloid complex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09867
hsa-miR-548d-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
GSE158431_2_v_0_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
coronary artery disease	GWASdb SNP-Disease Associations	1.0	1.42467
SKP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00623005
GSE203362_0_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_AZD1480_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154725
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVUS-0011-R9A-SM-3GIJA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1177
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE111660_1_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CA-75-HA22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.396634
VZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.944432
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5832-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K57724551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63292
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AT 406	DeepCoverMOA Drug Mechanisms of Action	1.0	0.31
BRD-K82509605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61467
BRD-K19103580	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02644
GSE116894_1_v_0_tle3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K40175214_torin-1_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pruritus	CTD Gene-Disease Associations	1.0	1.05864
GSE193177_1_v_0_st266_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TSE9-3026-SM-3DB76	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838698
GTEX-T5JW-0008-SM-4DM5X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.116
HT144SKINFV1	DepMap CRISPR Gene Dependency	1.0	2.91356
specific granule membrane	GO Cellular Component Annotations 2023	1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.332454
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939731
GSE135439_0_v_1_pax5_human	RummaGEO Gene Perturbation Signatures	1.0	null
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
U87MG	DepMap CRISPR Gene Dependency	1.0	2.51902
HCK	MSigDB Cancer Gene Co-expression Modules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5324-01A-01R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123265
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.486
vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-RVPU-0011-R10A-SM-2XCAH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.52338
Eca-109 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.654
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ARL5C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00642735
GSE157555,GSE157556_5_v_1_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TSE9-0526-SM-3DB7Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872577
H3K4ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ELAVL1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_12661_KD_RAB7_SRP017435	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.90911
DOK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00721
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.612479
PMC7021759-41467_2020_14682_MOESM10_ESM.xlsx-downregulated_genes-Table_S7_Dowregulated_genes_in_SKNMM_and_U2OS_cells_with_MYCN_induction_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
STAT1-17558387-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
membrane	LOCATE Curated Protein Localization Annotations	1.0	null
GSE128240_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PUF60	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75053
PIR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00591357
BRD-A80968824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09411
Perturb_9139_OE_MIR146A_SRP136059	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.4157
PMC4013678__F2	PFOCR Pathway Figure Associations 2023	1.0	null
GSE140651,GSE140653_2_v_4_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_3_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RWS6-2126-SM-2XCAV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33249
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_PCI-34051_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143212
GSE147943_2_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2502_EFTUD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.932821
appendices_4a	HPA Tissue Sample Gene Expression Profiles	1.0	0.862449
KDM5B-21448134-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K48519079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03063
GTEX-T6MN-0011-R8A-SM-32QP3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832569
BRD-K53241408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44767
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A35588707_TENIPOSIDE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PHF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07633
3050_FDPS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.53796
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE139975_3_v_0_rnf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228162_2_v_5_nr2f6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE161295_0_v_5_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8652
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU601	DepMap CRISPR Gene Dependency	1.0	2.11197
PMC8027210-41423_2020_615_MOESM5_ESM.xlsx-CT4-_CCR6_RORC-gene_RORC	Rummagene Transcription Factor Associations 2026	1.0	null
17616640-TableS3	GeneSigDB Published Gene Signatures	1.0	null
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00704
mammarygland.lact.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.98969
KLF4-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
9453_TXNDC9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.579359
PMC12623973-41467_2025_64981_MOESM3_ESM.xlsx-downregulated-c0_ACKR4_SCS_ceiling_LEC_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
SOX2-21211035-LN229-GBM	ChEA Transcription Factor Targets 2022	1.0	null
BL70	DepMap CRISPR Gene Dependency	1.0	5.01166
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7395714__F1	PFOCR Pathway Figure Associations 2024	1.0	null
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3163	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
SCLC-22H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09704
Colon carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
enzalutamide_homo sapiens_gpl570_gse44905	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968601
KLF4	ChEA Transcription Factor Targets	1.0	null
JUN_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K90594901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29997
BRD-K56214240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24347
tm4sf	GeneRIF Biological Term Annotations	1.0	null
ventrolateral prefrontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.49325
hsa-let-7d	TargetScan Predicted Conserved microRNA Targets	1.0	0.248923
hsa-miR-194	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
VZ in caudal cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.892332
hsa-miR-3689d	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.36389
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.924672
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.474099
Fatty Liver	CTD Gene-Disease Associations	1.0	1.98857
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.761185
OC-71-BZ81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.483757
BRD-K42308740_ST056792_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
imatinib_homo sapiens_gpl96_gds3049	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Urinary bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
IRF1	ENCODE Transcription Factor Targets	1.0	null
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Unnamed_13_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K01152687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07339
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36194
GSE171269_1_v_3_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AsPC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.745
MCF7_Alvespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148396
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.9805
Plasmacytoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.673
CREB1-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
4908_MCOLN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.514751
organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
blast cell	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.572872
chr3_32401667_G_C_b38	GTEx eQTL 2025	1.0	1.16279
GSE216043_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K45589340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44851
GTEX-SSA3-0005-SM-32QOT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979739
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054382
Caki-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.771
Bladder Urothelial Carcinoma_BLCA_TCGA-FT-A3EE-01A-11R-A206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2828-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OOBK-0008-SM-3NB27	GTEx Tissue Sample Gene Expression Profiles	1.0	0.924835
GSE226091,GSE226092_3_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Atrophy	CTD Gene-Disease Associations	1.0	1.34518
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK1	ENCODE Transcription Factor Targets	1.0	null
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.77979
GSE200687,GSE200688_1_v_0_sox15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K85965830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85903
posteroventral (inferior) parietal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.843864
Choline	CTD Gene-Chemical Interactions	1.0	null
SELL	MSigDB Cancer Gene Co-expression Modules	1.0	null
Blood Coagulation Disorders	CTD Gene-Disease Associations	1.0	1.53159
GTEX-XQ8I-0626-SM-4BOPT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07385
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
QF-00-CY91_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25203
BCL3	ENCODE Transcription Factor Targets	1.0	null
hematopoietic system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-QCQG-0008-SM-48U2G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852887
GSE220693_1_v_0_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01985
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fostamatinib (disodium hexahydrate)_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0203239
GTEX-NL3H-0008-SM-4E3HU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886797
GTEX-SNOS-0008-SM-4DM6I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20886
FD-35-PQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263562
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung-dendritic cell	Tabula Sapiens Gene-Cell Associations	1.0	0.104238
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.845745
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDAMB134VI	CCLE Cell Line Gene CNV Profiles	-1.0	-1.65487
CSTB_KO_GDS5090_398_mouse_cerebella	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A631-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH510	DepMap CRISPR Gene Dependency	1.0	2.35212
cytoskeleton	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
2747_ESYT1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.22778
METTL8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30343
DC-51-WE27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.279133
CRCGN015_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5233
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0914
OVCAR5	BioGPS Cell Line Gene Expression Profiles	1.0	1.75366
VZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02501
CALU	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00406814
MEF2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE195568_3_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
early endosome membrane	GO Cellular Component Annotations 2025	1.0	null
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5505-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCT-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.972
FZD9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00460667
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07228
10202_ZNF207_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.662774
KD-50-WP70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.329623
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE228413_4_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
gracile nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.17655
Fetal Death	CTD Gene-Disease Associations	1.0	1.61874
TCF12	ENCODE Transcription Factor Targets	1.0	null
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE238005_0_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	1.0	null
RAB26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58325
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Supplementary_Table_2B_Contrast_ATF4-def_DMSO_2h_vs_HCT116_DMSO_2h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
Myelinating Schwann cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.933
GSE71491_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K78431006_crizotinib_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-SIU8-0526-SM-2XCDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37791
KDM5B	ENCODE Transcription Factor Targets	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
hsa-miR-4725-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
CASP1	MSigDB Cancer Gene Co-expression Modules	1.0	null
Lytic vacuole	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE135030_8_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE188382_2_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.51067
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE195582_0_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE157555,GSE157556_0_v_6_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
C170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K55402144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1253
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8341-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
14767473-Table3	GeneSigDB Published Gene Signatures	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.57455
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
MCF7_G007-LK_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157384
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.13478
GSE120612_7_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UTHO-2926-SM-3P5Z9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880367
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.828
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.30392
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11A-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE180200,GSE180201_12_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SERPINA6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00423393
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.33006
GSE148252_7_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K42032479	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15456
BRD-K07303502_Arachidonyl trifluoro-methyl ketone_A375_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K44950949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.85966
BRD-K98109987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60428
GSE225218_2_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
2122_DDX46_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.513222
GSE77795_2_v_1_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-4693-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.864
family	GeneRIF Biological Term Annotations	1.0	null
CAL-85-1	GDSC Cell Line Gene Expression Profiles	1.0	1.63925
STAT5-23275557-MAMMARY-EPITHELIUM-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K61742182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45726
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN008_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.79705
GSE103068_0_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
BRD-K79090631_CGP-60474_HCC515_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K52123365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40151
outer CP in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.825693
GSE144231_2_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1155	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00024
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271437
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.96917
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal homeostasis	MPO Gene-Phenotype Associations	1.0	null
prostate gland epithelium	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN017_MCF10A.WT.HP_24H:E04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.80966
BRD-K74150320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41158
Cell Transformation, Neoplastic	CTD Gene-Disease Associations	1.0	1.16434
Lysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.201
2376_DROSHA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.09747
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A45889380_QUINACRINE HYDROCHLORIDE_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57245
hsa-miR-215-5p	MiRTarBase microRNA Targets	1.0	null
CHD4-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	1.0	null
EP300_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213219_0_v_1_st3gal3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MPC-11 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.789
H3K27ac_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE158834_10_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WQUQ-1426-SM-3MJFD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52066
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.07715
Adenoma, Liver Cell	CTD Gene-Disease Associations	1.0	1.10246
Esophageal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.093
LDL cholesterol levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.71549
GSE183271_4_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE249098_3_v_0_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE220520_1_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K54079231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23367
hsa-miR-4723-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
CTCF_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.26866
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12514
GSE57871_5_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAL1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8065135-41467_2021_22068_MOESM6_ESM.xlsx-E_MYOG_binding_in_downreg-Unnamed_1_MYOG	Rummagene Transcription Factor Associations 2026	1.0	null
Squamous Cell Carcinoma Of The Head And Neck	DisGeNET Gene-Disease Associations	1.0	null
GSE84922,GSE84924_0_v_3_sall4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K35413741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13892
ventrolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20367
eltanolone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6173
FKBP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0407
Disc floret	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.764
GSE205976,GSE205978_1_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125219,GSE125221_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cetuximab_homo sapiens_gpl570_gse21483	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RVPU-0011-R3A-SM-2XCAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889918
7332_RNASEK_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.572751
FE-59-BC81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232493
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K27121064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17142
GSE138938_1_v_3_foxp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AE-07-IZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.322621
SALE	CCLE Cell Line Gene Expression Profiles	1.0	1.91226
CSTB_KO_GDS5090_200_mouse_Cerebellar granule cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE77108_6_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A58937872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23205
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A6C5-11A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_AG-490_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143076
GSE198165,GSE198166_9_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GRHL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9744
CW-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.865551
GATA1_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
U20S	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.14599
GTEX-OXRO-0011-R10A-SM-2I5EH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881126
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03994
BRD-K34277236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15728
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K63909265	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04502
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0079
H3K79me2_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2888-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cranium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.348148
BRD-K63892351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56326
SRD5A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25577
Adrenocortical carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
OS252	DepMap CRISPR Gene Dependency	1.0	2.22752
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HAVCR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00507343
GSE210476_9_v_8_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7691587__F3	PFOCR Pathway Figure Associations 2023	1.0	null
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K60484506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28258
GSE139987_1_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE166920_6_v_3_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LB-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1588	CCLE Cell Line Gene Expression Profiles	1.0	1.39921
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04621
MCF7_PFI-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122677
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3148	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE100316_0_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835372
SPI1	ChEA Transcription Factor Targets	1.0	null
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE148263_6_v_9_trim3_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
Perturb_13039_KD_Tardbp_SRP314028	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	18.3468
Prdm15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.6486
external granular (germinal) layer of lower rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16118
GTEX-RUSQ-0526-SM-2TF72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.97314
GTEX-POYW-0008-SM-48TE4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839033
GSE70935_3_v_5_cyfip1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TMZS-0326-SM-3DB9P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.73829
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A46778020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.3509
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H847	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01528
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE172020_0_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Fibrosis	CTD Gene-Disease Associations	1.0	1.97508
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE181003_3_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K13566078_BMS-345541_SKBR3_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-548ac	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
GSE151090_2_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
membrane-bounded vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Bile duct cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.253
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-3_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
SKNBE2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38393
PPM1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30659
BRD-K88758204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12454
20460173-ImmPortCytokines	GeneSigDB Published Gene Signatures	1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.704
Low density lipoprotein cholesterol levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.8699
Tremor	CTD Gene-Disease Associations	1.0	1.05237
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.80186
BRD-K19106745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42944
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09877
Rectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Ensembl_ID_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.870569
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.52171
GSE205976,GSE205978_1_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
OC-10-FB51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.44411
A549_Disulfiram_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137098
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Skeletal Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K17549032	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94098
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	1.0	2.69757
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.16633
GTEX-P4QR-0726-SM-2I5GO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33288
CRCGN015_MCF10A.WT.HP_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.08113
PMC12211054-spectrum.00100-25-s0002.pdf-57-CIC_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredProteinGroups-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
primary motor cortex (area M1, area 4)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17382
BRD-K57019930_1288-0508_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE76771_1_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hodgkin's lymphoma, nodular sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135058
18160665-TableS5	GeneSigDB Published Gene Signatures	1.0	null
capan2	HPA Cell Line Gene Expression Profiles	1.0	1.33929
abnormality of cholesterol metabolism	GWASdb SNP-Phenotype Associations	1.0	1.21853
MUTZ5	CCLE Cell Line Gene CNV Profiles	-1.0	-1.74844
FOXA2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51497
UB-41-DY23_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204799
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Trichostatin A_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00889593
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244604
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.57693
CSTB_KO_GDS5090_199_mouse_Cerebellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Lytic vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.201
amygdaloid complex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.28726
HCC202	CCLE Cell Line Gene Expression Profiles	-1.0	-3.29783
GSE167324_1_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31134
8216_SNRNP200_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.695179
Bipolar Disorder_Cerebral cortex_GSE12649	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.5388
MCF7_MK-0752_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013877
SP in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08161
GSE155162,GSE155169_1_v_2_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.842483
PMC11629966-btae696_supplementary_data.docx-18-FOSL2_FOSL2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE210476_11_v_7_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SK-MEL-24	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12585
GSE135312_1_v_2_bmpr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K85843964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44423
ES-WA7 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.28288
CRCGN008_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3423
ALDH18A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00417856
SG in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16455
GSE158197_2_v_11_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12269
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4698-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QMRM-0008-SM-447B1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949972
brain	GTEx Tissue Gene Expression Profiles	-1.0	-1.08296
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	1.0	2.02997
JARID1B-DAIN-22020125-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-577	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
SP110	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00520123
Lung squamous cell carcinoma_LUSC_TCGA-39-5029-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
leukocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
abnormal circulating bilirubin level	MPO Gene-Phenotype Associations	1.0	null
upper (rostral) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.837047
hsa-miR-1260b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GSE140607_5_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Ovary adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
POLR2A_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
globus pallidus, internal segment, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.911755
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.71039
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-2.10021
AHR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00402506
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A45889380_QUINACRINE HYDROCHLORIDE_NCIH2073_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_CUDC-101_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0219683
4540_LDB1_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.941242
Arnt::Hif1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.2212
BRD-K59130783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0032
GATA2	ENCODE Transcription Factor Targets	1.0	null
TAF1	ENCODE Transcription Factor Targets	1.0	null
GSE158834_1_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.46368
17533364-TableS3	GeneSigDB Published Gene Signatures	1.0	null
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907977
A-CA-04-2009(H1N1)_12Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.39391
GTEX-TSE9-0011-R5A-SM-3DB7J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43778
GTEX-XBEC-0008-SM-4AT3X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949805
GSE167886_3_v_1_chd7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.386917
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20286
CD19+_BCells(neg._sel.)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.969903
DB	DepMap CRISPR Gene Dependency	1.0	2.31759
ChIP_KLF4_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-T8EM-1326-SM-3DB7G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34352
C75	DepMap CRISPR Gene Dependency	1.0	2.15531
BRD-K79090631_CGP-60474_HA1E_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_17560_KD_EFB1_SRP357509	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE171175,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-PW2O-0008-SM-48TEB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2225
GSE151829,GSE151831_1_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2789-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4495	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
4271_KANSL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.592449
2548_EIF3D_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.525131
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-U31801276_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RSC1A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00540884
E2F1-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE212760_0_v_1_fxr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
KMS-28BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09344
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.854815
fallopiantube_8b	HPA Tissue Sample Gene Expression Profiles	1.0	1.23118
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.48843
PMC11040904__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JM-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMC3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DGKQ	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0064924
MCF7_Aurora A Inhibitor I_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151995
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.662703
CEBPD	ENCODE Transcription Factor Targets	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LH-01A-21R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE174406_2_v_1_lin28b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K18519621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06149
GSE135030_8_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE92364_0_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-L1-A7W4-01A-12R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BA-19-VU85_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.311591
CRCGN010_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65809
GTEX-X4XX-0011-R10B-SM-46MWO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.845546
Stomach carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.303
caki2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.658
GSE213228_4_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PCIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0438
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9RC-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
CRCGN016_MCF10A.TP53.M_24H:D21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2153
TE1	CCLE Cell Line Gene CNV Profiles	1.0	1.71616
CTCF_fibroblast of pulmonary artery_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE180200,GSE180201_2_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GATA3_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nitrogen compound transport	GO Biological Process Annotations 2025	1.0	null
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.979797
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.870569
Cholestasis	CTD Gene-Disease Associations	1.0	1.21141
BRD-K88924787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37338
MCF7_Danusertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202999
primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.870569
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07265
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PANC 03.27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.824774
EE-98-PF86_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237557
Weight Loss	CTD Gene-Disease Associations	1.0	1.83984
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80264
GSE220806_1_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Zileuton_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149649
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BF-59-OR93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.300138
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10722
GTEX-WFJO-0008-SM-4LVN7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22846
GSE169205_0_v_8_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
19841744-TableS5	GeneSigDB Published Gene Signatures	1.0	null
BRD-K61439332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13207
GSE128844_0_v_1_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203041
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.976988
biological_process	GO Biological Process Annotations 2015	1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K95864593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2387
2893_TAFA2_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.602093
Perturb_8707_KD_SIRT1_SRP267968	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.33172
NR1H3	ChEA Transcription Factor Targets	1.0	null
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K43820045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12113
BRD-K46085646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24319
CRCGN014_HEPG2_3H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.125
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CM-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO 800	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.923143
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5443-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE254848_4_v_3_ptges_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12514
GSE148692,GSE148695_2_v_6_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-let-7e	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.090078
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.994478
GSE73562,GSE73563_1_v_2_preb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6087-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12061
hsa-miR-1293	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GSE102505_1_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223334_3_v_2_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.803
BRD-K77820762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04934
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QDVN-2426-SM-2S1Q4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944722
GTEX-RN64-0008-SM-48FEZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38943
GM12878	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	2.10611
GSE144115_2_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL-85-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.20207
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81741
uterine cervix	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Hepatic Encephalopathy	CTD Gene-Disease Associations	1.0	1.22306
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4074-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
extracellular organelle	GO Cellular Component Annotations 2015	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2981-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17145
MBNL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00489611
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
1408_CDC5L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.702615
Prostate adenocarcinoma_PRAD_TCGA-EJ-5532-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE179880_10_v_6_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.515
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01876
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29982
GTEX-PLZ4-0926-SM-2S1OI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37028
PMC5524348-pone.0181667.s005.xlsx-Inflammation-MINT_SPEN	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WCDI-0008-SM-47JYE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23937
PMC9399107-41467_2022_32627_MOESM6_ESM.xlsx-7_B-cell_subsets-gene_name_Bcell_C5_NR4A1_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO205	BioGPS Cell Line Gene Expression Profiles	1.0	0.96687
myeloid progenitor cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NPLOC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34506
WHSC1	ENCODE Transcription Factor Targets	1.0	null
NR1H3-23393188-ATHEROSCLEROTIC-FOAM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.478
GSE152441,GSE152442_6_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CDS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11085
GTEX-RWSA-0008-SM-47JYX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04013
GSE86507,GSE86509_7_v_2_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WM2664_SKIN	CCLE Cell Line Proteomics	1.0	5.33243
hsa-miR-526b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881098
Ikzf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.3483
GSE166920_6_v_8_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199541_2_v_4_mbd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.974936
GSE125219,GSE125221_3_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QVJO-0008-SM-447AU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07167
UE-90-AA63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218143
Cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE60367_2_v_1_cxcr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KYSE150	CCLE Cell Line Gene Expression Profiles	1.0	1.83194
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3348545-NIHMS263168-supplement-3.pdf-73-SATB1_SATB1	Rummagene Transcription Factor Associations 2026	1.0	null
MYO5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02537
protein transport	GO Biological Process Annotations 2023	1.0	null
PMC11076560-42003_2024_6230_MOESM5_ESM.pdf-49-ENSG00000025434_NR1H3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE176008_8_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-3943	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
SCC-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.964
CRCGN009_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31508
inner CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.62883
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LB771HNC	DepMap CRISPR Gene Dependency	1.0	2.4176
LN18	BioGPS Cell Line Gene Expression Profiles	1.0	0.935221
mRNA_NANOG_16767105	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
MCF7_PF-573228_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177134
COPS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17393
BRD-K81465091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04709
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
extracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33641
SF268	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.903805
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	2.26355
cyclosporine_homo sapiens_gpl4133_gse25200	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
16909099-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26134
496100438_PCx_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.52225
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.578
GSE192513,GSE192515_2_v_0_atg16l1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Rix1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.787
GTEX-XUZC-0008-SM-4BOQG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16483
HUPT4	CCLE Cell Line Gene Expression Profiles	1.0	2.755
GSE210101,GSE210114_2_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH1963	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37548
GTEX-N7MT-0011-R2a-SM-2I3GI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01602
CRCGN008_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2106
CASP4	MSigDB Cancer Gene Co-expression Modules	1.0	null
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-8264-01B-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE132386_2_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A-CA-04-2009(H1N1)_48Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.80629
GSE234340_1_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
1779_COPS3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.517098
BRD-A70649075_SULCONAZOLE NITRATE_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM12864_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210101,GSE210114_2_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
brain_3c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.944069
GSE190950_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRCA1	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27785
binding	GO Molecular Function Annotations 2015	1.0	null
ARTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01491
nicotine_mus musculus_gpl1261_gse31004	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE84678,GSE93902_3_v_2_bcl11b_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K61733751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20435
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K25203350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17776
SRC_overexpression_276_GSE37428	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-3.29919
4691_LSM2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.664835
GTEX-U3ZN-1226-SM-4DXUD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16048
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2744-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE102269_1_v_2_clpp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE139455_2_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XBED-2626-SM-4E3J5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1538
CUX1	ENCODE Transcription Factor Targets	1.0	null
GOSR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05725
WF-96-ME07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.527653
RUNX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.754
primary motor cortex (area M1, area 4)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.873729
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.03507
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7838-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0008-SM-33HB1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43378
GSE166920_6_v_4_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC2866657-pone.0010547.s003.xls-ESE3_corr-Genes_correlated_anticorrelated_to_ESE3_EHF	Rummagene Transcription Factor Associations 2026	1.0	null
ovary	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K64860662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16069
PCCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41658
GTEX-RVPU-0008-SM-3NM8B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846624
LIVF001-021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.87542
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.27164
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
VF-79-GQ03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266494
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.861775
5535_NDUFA2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.555628
BRD-K11641139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08366
IA-13-FI66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.363051
EXTL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00635001
BRD-K53291208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18971
ZNF274	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.805
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organic substance transport	GO Biological Process Annotations 2023	1.0	null
BRD-K23905877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8498
GSE88819_6_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mecom	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.0
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
7393_RNF4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.580233
hsa-miR-548c-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.17031
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.75364
internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Uterine carcinosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.358
JD-10-HW02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261007
Perturb_1490_KO_Rpl23a_SRP056432	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.76018
hsa-miR-568	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
GSE132759_4_v_2_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE113106_0_v_5_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A673_BONE	CCLE Cell Line Proteomics	1.0	2.98682
CRCGN016_MCF10A.TP53.M_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.3199
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.73295
GTEX-OIZG-1126-SM-2HMIU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11292
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.829167
GTEX-S7SE-0011-R7A-SM-2XCDI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13957
GSE152937_12_v_7_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UJHI-1726-SM-3DB9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20029
hippocampus (hippocampal formation)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.853211
4958_MED8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.538161
P300-27058665-CHIP-SEQ-ZR-75-30CELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
A549_PF-3845_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144349
HOP92	BioGPS Cell Line Gene Expression Profiles	1.0	1.39904
GSE158834_11_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41R-01A-21R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Endocervical adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.093
GSE112761,GSE112767_2_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.851824
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1395	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45452
Lewis lung carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.934
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7512_RPS23_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.525574
primary motor cortex (area M1, area 4)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.12852
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
16397240-SuppTable9	GeneSigDB Published Gene Signatures	1.0	null
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24242
Esophageal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.349
CRCGN010_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36152
GSE165579_0_v_1_opa1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10577
GSE209698_0_v_1_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
specific granule membrane	GO Cellular Component Annotations 2025	1.0	null
BRD-K37764012_PF-3758309_HCC515_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
E2F1-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
ATP6V1F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26217
CRCGN008_HEPG2_24H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0393
OVCAR-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.82447
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.163495
Exanthema	CTD Gene-Disease Associations	1.0	1.33791
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.28804
Perturb_7485_OE_Mir489_SRP155560	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.9546
CPCN	CCLE Cell Line Gene Expression Profiles	-1.0	-2.17202
Lung adenocarcinoma_LUAD_TCGA-38-4631-01A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052156
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5C0-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA6-25053715-YYC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94259
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.428765
NCI-H1793	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.995681
A-498	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.84182
GTEX-SUCS-1626-SM-32PLS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.919572
RUNX1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K40816903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13309
PMC3435504-msb201237-s2.xls-Supp_Table_4a-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K56241426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03813
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.8152
MCF7_Ki8751_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0112543
mononuclear cell	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.387
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.509
GSE154577_7_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.79917
brain	HPA Tissue Gene Expression Profiles	-1.0	-1.03657
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SHSYSY+RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.862678
STRADA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0068365
A549_CEP-33779_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122306
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
FXYD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17327
MCF7_TGX-221_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139257
GABPA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
IL2RG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00692289
812_BCR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.507236
A549_UNC0379_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125546
Sarcoma_SARC_TCGA-DX-A3U8-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29G-06A-12R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7839_SF3B5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.580148
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
fallopian tube	HPA Tissue Gene Expression Profiles	1.0	2.24723
769-P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32663
hsa-miR-150	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
NR3C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5983
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mafb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.0178
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4985-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_PFI-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215007
GSE131588,GSE131690_1_v_0_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ADK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00509806
BRD-K45628030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02899
urinarybladder_5c	HPA Tissue Sample Gene Expression Profiles	1.0	1.02174
hippocampus	HPA Tissue Protein Expression Profiles	-1.0	-0.816233
CEBPB_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
16166195-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
FZD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00632841
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.179
DNASE1L3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00582189
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE174586_0_v_1_slc4a11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
outer CP in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.921576
B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.086
GSE220520_6_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-548u	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT1	ENCODE Transcription Factor Targets	1.0	null
SARS-dORF6_48Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.17655
Head and neck squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.91
posteroventral (inferior) parietal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16657
GTEX-O5YU-0008-SM-4E3I7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09598
BRD-A68065211_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
MC-38 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.819
Pax7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.7022
Perturb_11108_KO_Cpt2/Ppara_SRP303636	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.2777
GTEX-NPJ8-0426-SM-2HMK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998374
DE-03-NP53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248442
H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE152699,GSE152723_3_v_2_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111247_2_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SARS-dORF6_36Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.1271
ventrolateral prefrontal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30259
PGR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0051172
hsa-miR-4500	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
hsa-let-7a	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34493
CRCGN009_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3318
GSE231799_3_v_1_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Maraviroc_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141319
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871705
GSE196117_1_v_8_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
8155_SMC1A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.564232