association	dataset	threshold value	standardized value
A549_AG-14361_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0333459
SARC9371	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_A-366_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.045948
GTEX-WFON-1326-SM-4LVMN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46735
chlorcyclizine-4546	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KYO1	DepMap CRISPR Gene Dependency	1.0	3.43697
GTEX-X4XY-0926-SM-4E3JD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1315
RT112	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44257
A549_TGX-221_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.035459
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SKN3	DepMap CRISPR Gene Dependency	1.0	2.21658
A549_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0468387
CRCGN015_MCF10A.WT.HP_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.39175
YKG-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-OIZI-1326-SM-3NB1B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9444
A549_JQ1_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0560115
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
SW780	GDSC Cell Line Gene Expression Profiles	-1.0	-1.55528
GSE238116_1_v_0_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XGQ4-1226-SM-4AT67	GTEx Tissue Sample Gene Expression Profiles	1.0	0.936246
PMC7862469-13238_2020_779_MOESM4_ESM.xlsx-FOXO3-GE_VS_WT-GeneID_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
A549_Decitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0665023
GSE99687_2_v_1_smad5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.987394
GTEX-QMR6-0008-SM-447AV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15629
pirenzepine-5872	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0645322
HEC-1	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.13327
u698	HPA Cell Line Gene Expression Profiles	-1.0	-1.05471
hsa-miR-4540	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organism form	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE242199_6_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MDA-MB-415	GDSC Cell Line Gene Expression Profiles	-1.0	-1.47395
A549_SRT3025 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0670924
A549_AG-490_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0771962
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-O5YT-0226-SM-32PK5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97128
GTEX-PLZ4-0226-SM-2S1NW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27646
A549_PCI-34051_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0477549
A549_Flavopiridol HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0486972
GTEX-XXEK-0008-SM-4BRW7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
A549_Roxadustat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0681959
TT2609C02	DepMap CRISPR Gene Dependency	1.0	2.8692
GTEX-S3XE-0826-SM-4AD4U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60269
496100340_TCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.72612
A549_Tozasertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020838
A549_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0570646
CRCGN017_MCF10A.WT.HP_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0089
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EFO-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.53332
GSE238018_3_v_0_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_BRD4770_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.074051
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-R53T-1626-SM-3GAEW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01779
GSE225901_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
HCC202	CCLE Cell Line Gene CNV Profiles	1.0	1.63637
HCC202	DepMap CRISPR Gene Dependency	1.0	4.82611
A549_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020231
EFEMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01053
GSE216238,GSE216241_0_v_1_tonsl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.56626
GTEX-PLZ6-0626-SM-3P61B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93195
A549_Iniparib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0271602
RPL21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73186
LXF-289	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.987394
A388	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.50158
lymphnode_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.53197
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19793
GTEX-O5YT-0726-SM-3MJHA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9422
CHLA10	DepMap CRISPR Gene Dependency	1.0	2.08861
hsa-miR-509-3-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
A549_Avagacestat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0317102
naltrexone-5765	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TTL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13842
GTEX-SE5C-0008-SM-4B64J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07033
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876233
GTEX-R53T-1026-SM-48FCO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02768
Clopidogrel_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00784026
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.234
GTEX-P4PQ-0008-SM-48TDX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12935
Left ventricular noncompaction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.164
A549_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0295924
CRCGN014_HEPG2_24H:J15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9112
A549_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0324521
hsa-miR-214	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18659
D-247MG	GDSC Cell Line Gene Expression Profiles	1.0	1.95754
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN012_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77361
GTEX-QLQW-0626-SM-447A6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85517
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Tie2 kinase inhibitor_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.057539
A549_Daphnetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0445222
A549_S3I-201_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0297497
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28433
microbody	LOCATE Predicted Protein Localization Annotations	1.0	null
IC-21 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.947
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
beta-escin-4544	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Danusertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0404429
GTEX-XYKS-1026-SM-4BRVH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824942
ZNF568	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0889
A549_Aurora A Inhibitor I_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0321051
hsa-miR-3666	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
A549_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0517652
GTEX-NFK9-0008-SM-4E3JE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06168
A549_Anacardic Acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0446014
Amebiasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.032
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PX3G-0726-SM-48TZT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5302
17880687-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GR-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48038
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17024
GTEX-OHPK-2426-SM-3MJGH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26974
NMUR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88834
UACC62	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47474
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.987394
GSE85880,GSE85881_0_v_2_tretinoin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-UJHI-1426-SM-3DB9C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17444
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.918546
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.885287
GTEX-V1D1-0008-SM-4JBIJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
nitrendipine-6304	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
M6PR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46568
NCI-H2171	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.082
A549_MLN8054_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0279556
PMC9618568-41467_2022_34255_MOESM4_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
astroblast	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_JNJ-26854165_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0346358
LDHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.66742
GSE178714_5_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.89287
19505326-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
hsa-miR-301a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
COLO800	DepMap CRISPR Gene Dependency	1.0	2.2051
CRCGN013_HEPG2_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27722
Perturb_15594_KD_PPARG_SRP049523	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
SCABER	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN015_HEPG2_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.79083
17880687-TableS1	GeneSigDB Published Gene Signatures	1.0	null
hsa-miR-1288	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
A549_IOX2_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0331033
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1759
H3K27me3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
hsa-miR-4692	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GSE175787_4_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH460	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34739
GSE158182_5_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.923364
GTEX-RWS6-0008-SM-47JYV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
hsa-miR-3671	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
GSE202434,GSE202438_9_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Curcumin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0677569
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Tozasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.065109
interleukin-15 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.691
JVE253	DepMap CRISPR Gene Dependency	1.0	2.20825
A549	DepMap CRISPR Gene Dependency	1.0	2.45763
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PX3G-0008-SM-48U2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
A549_Linifanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0519079
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-C_ATF4-def_vs_HCT116_DMSO8-Supplementary_Table_2C_Contrast_ATF4-def_DMSO_8h_vs_HCT116_DMSO_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QMR6-1926-SM-32PL9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10362
GTEX-R55D-0008-SM-48FEV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01382
GSE236486_1_v_2_arnt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3622
CRCGN016_MCF10A.WT.HP_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.59825
Perturb_14100_KO_ARID1A_SRP355686	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE150072,GSE169209_4_v_11_qser1_human	RummaGEO Gene Perturbation Signatures	1.0	null
chr9_42032082_C_T_b38	GTEx eQTL 2025	1.0	1.82154
A549_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0486884
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE229973_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Selisistat_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0685766
CRCGN017_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.17335
hsa-miR-4418	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GSE242521,GSE242522_0_v_1_mettl3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0316143
felbinac-5700	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.884255
DBF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71122
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Vasculature-endothelial cell	Tabula Sapiens Gene-Cell Associations	1.0	2.38131
hsa-miR-876-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GSE184087_2_v_3_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE221327_4_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Filgotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0538678
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RRP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.59665
ZNF234	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.478
Uterus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.22409
A549_G007-LK_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0644885
A549_Ruxolitinib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0294189
HD-MY-Z	GDSC Cell Line Gene Expression Profiles	1.0	2.49385
A549_Flavopiridol HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0225783
hsa-miR-3187-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
A549_CUDC-907_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0701997
GSE206984_1_v_0_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE168797_4_v_3_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PWOO-2226-SM-2S1P1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87611
Testicular cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RT-112	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
A549_Resveratrol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0213452
A549_MK-0752_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.057179
gabexate-4220	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
carbenoxolone-4093	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0624375
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Colorectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.082
FAM110C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06811
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0337
IKZF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22132
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.2159
H3K27me3_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A549_BMS-911543_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0225445
GTEX-OXRL-0008-SM-3NB29	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31697
GSE147876,GSE147877_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4572
RPL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46137
CRCGN014_HEPG2_3H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.34705
GTEX-P4PP-0008-SM-48TDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2137
GTEX-U3ZN-2626-SM-3DB7T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21729
ivermectin-5853	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Dacinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0490921
GTEX-R55E-0326-SM-48FD2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965968
ZNF841	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09653
KARPAS422	DepMap CRISPR Gene Dependency	1.0	2.57863
A549_Ofloxacin_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0660741
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A549_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0228641
GTEX-T2YK-0008-SM-4DM6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05167
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0425
A549_Dacinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0585767
POMGNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39963
A549_XAV-939_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158259
GSE229070,GSE229071_0_v_2_sotorasib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WH7G-1026-SM-4LVML	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30555
A549_PF-573228_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0747986
CRCGN014_HEPG2_24H:H13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08984
A549_UNC1999_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0277529
A549_Clevudine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.056995
G122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11884
GTEX-REY6-2426-SM-48FF5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922251
496100337_HIP_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.31572
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36541
A549_ITSA-1_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0458531
A549_PJ34_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0495912
A549_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0541332
GTEX-S7SE-0226-SM-2XCD4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979756
GTEX-XBEW-0008-SM-4AT3Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33533
GSE140997_10_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5441
JUND_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.11053
SPIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.6502
A549_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0505965
vacuole	LOCATE Predicted Protein Localization Annotations	1.0	null
hsa-miR-4804-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
A549_CYC116_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145383
ovary	HPA Tissue Gene Expression Profiles	-1.0	-1.20418
GTEX-XBED-1126-SM-48TCF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877043
A549_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0393955
A549_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0761427
A549_TMP195_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0346501
CRCGN012_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8863
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27073
H2731	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XUJ4-0926-SM-4BOPA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07661
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
TT1TKB	DepMap CRISPR Gene Dependency	1.0	4.24372
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Ensembl_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CCT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2434
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4465	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
A549_Costunolide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0350558
CRCGN008_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61295
GSE202434,GSE202438_6_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3642
GTEX-R55G-0008-SM-48FEX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.906452
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Streptozotocin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.069836
JIYOYE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.53676
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.67371
PMC10082806-42003_2023_4756_MOESM4_ESM.xlsx-AML2_RelvsTum_DMRs_anno-annot_symbol_RUNX3	Rummagene Transcription Factor Associations 2026	1.0	null
Chromatoid body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.792
HES3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64922
BV-173	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
GTEX-Q734-0008-SM-48U2I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21098
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942813
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30201
hsa-miR-4725-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.44101
GSE76425_1_v_7_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Danusertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169429
A549_Tranylcypromine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0706337
SW780	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
A549_Trametinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0843083
A549_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0263244
184A1N4	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.764817
A549_Vandetanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0332131
A549_Rucaparib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227737
GTEX-XPT6-0226-SM-4B65L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04489
A549_PFI-1_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0341131
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-N-AS	GDSC Cell Line Gene Expression Profiles	-1.0	-1.45696
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SK-CO-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
YSCCC	DepMap CRISPR Gene Dependency	1.0	4.50915
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUJ4-1726-SM-4BONW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883231
A549_AZD1480_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0273319
A549_Selisistat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0723245
GTEX-UPK5-1826-SM-3GAEB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.946604
GSE211128_2_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_BMS-754807_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143641
PMC9564215-pnas.2203480119.sd02.xlsx-OVCAR-5_SCD_KD_cultured_in_low-hgnc_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PSMD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45586
GSE188570,GSE188571_5_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.50589
GTEX-XUW1-0008-SM-4BOQH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887628
NMC-G1	GDSC Cell Line Gene Expression Profiles	1.0	1.43746
A549_Pirarubicin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0910511
Pancreas	GTEx Tissue Gene Expression Profiles 2023	1.0	1.6743
A549_MK-5108_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0463512
GTEX-SJXC-0426-SM-2XCFH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824815
ATF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5308
A549_AZ 960_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.058669
GTEX-QCQG-0008-SM-48U2G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
H3K27me3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.950164
kaempferol-5839	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_A-366_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175747
GTEX-T6MN-1526-SM-4DM5P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23126
A549_Fulvestrant_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.075275
hsa-miR-1587	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GTEX-PWN1-0008-SM-48TEA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849196
A549_Tofacitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212641
GTEX-SSA3-0008-SM-47JWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
A549_Fulvestrant_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0439076
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
A549_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0239339
TUBA1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	6.15339
A549_Entinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0414132
GTEX-QMRM-0008-SM-447B1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965393
GTEX-POMQ-2126-SM-2S1OJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.845784
CRCGN008_HEPG2_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4846
THOC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59575
Perturb_11920_OE_IRF3_SRP114539	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BICR31	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
HEC-1-A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.18434
hsa-miR-579	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
A549_UNC1999_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.014514
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17499
A549_Tanespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0658073
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29442
A549_Tazemetostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0568293
GTEX-S7SF-1826-SM-3K2AD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17077
GTEX-S7PM-0008-SM-3NM9Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11482
GTEX-T5JC-1826-SM-4DM6E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10994
Stomach	GTEx Tissue Gene Expression Profiles 2023	1.0	2.21364
A549_PHA-680632_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120922
Brain - Hypothalamus	GTEx Tissue Gene Expression Profiles 2023	1.0	1.2911
A549_JQ1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0323249
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900431
GSE221327_6_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF524	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93779
GTEX-X5EB-1726-SM-4E3J7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25566
A549_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0420793
GTEX-VJWN-0726-SM-3GIJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847799
SK-MEL-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.74066
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NMC-G1	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
A549_Sorafenib Tosylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0263553
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Roxadustat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0386961
carbamazepine-5093	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
496100465_HIP_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06985
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE210093_3_v_2_taf15_human	RummaGEO Gene Perturbation Signatures	1.0	null
tretinoin_homo sapiens_gpl6244_gds4180	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.79908
CRCGN009_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.48422
A549_Mocetinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0257682
A549_TG101209_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0402076
Polycystin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.567
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S341-0426-SM-4AD5L	GTEx Tissue Sample Gene Expression Profiles	1.0	2.06909
GTEX-XOTO-0726-SM-4B659	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824391
A549_AT9283_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.010387
BACH1	ENCODE Transcription Factor Targets	1.0	null
GTEX-T8EM-1126-SM-3DB7D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22345
A549_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0296748
A549_Divalproex Sodium_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0426843
GSE235066_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.25351
Fat-endothelial cell	Tabula Sapiens Gene-Cell Associations	1.0	11.3464
GTEX-WFG7-1626-SM-4LVMF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988332
NUP214	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64064
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OACP4C	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
hsa-miR-4282	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GTEX-VJYA-1026-SM-4KL21	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.948896
A549_Bisindolylmaleimide IX_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0467434
GTEX-S341-0008-SM-4AD6D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23246
A549_Hesperadin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0546208
GSE249098_1_v_2_mthfd1l_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Luminespib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0507652
A549_Ellagic acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0461138
GSE85880,GSE85881_0_v_1_tretinoin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MHH-PREB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MAPKAPK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0737
C2BBe1	GDSC Cell Line Gene Expression Profiles	-1.0	-2.04267
CRCGN010_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.90076
A549_UNC0379_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0428798
RO82-W-1	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
KNS-42	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_UNC1999_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0463762
RPMI7951	DepMap CRISPR Gene Dependency	1.0	3.39677
GSE146982_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1383
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
CRCGN010_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.96985
hsa-miR-4691-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE249404_0_v_1_oxytocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_PCI-34051_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0595656
KP-N-YN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Thymus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.947415
MKN1	GDSC Cell Line Gene Expression Profiles	1.0	1.84866
GTEX-Q2AH-0008-SM-48U2J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
Calu-6	GDSC Cell Line Gene Expression Profiles	1.0	1.64735
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_IOX2_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.04994
CRCGN015_MCF10A_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08631
JVM3	DepMap CRISPR Gene Dependency	1.0	2.77736
A549_Fasudil_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0737192
A549_Bisindolylmaleimide IX_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0323396
NCIH2004RT	DepMap CRISPR Gene Dependency	1.0	4.0699
NR3C1_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TNPO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56582
CTCF_LNCaP clone FGC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Divalproex Sodium_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0567026
CRCGN015_MCF10A.TP53.M_24H:L09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60725
GTEX-TMMY-1226-SM-4DXT6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40306
salivary gland	GTEx Tissue Gene Expression Profiles	1.0	0.976247
GSE70935_3_v_4_cyfip1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
EXOSC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05591
A549_EED226_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0289721
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15767
A549_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0606996
CRCGN014_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.0067
NCI-SNU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Serous cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.63
TOV21G	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7018
SARS-BatSRBD_12Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.88569
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H69	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H513	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236974
GTEX-T2IS-0008-SM-4DM75	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16658
A549_Barasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0327477
A549_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0243839
CRCGN015_HEPG2_48H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.08067
PTPN23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83314
GTEX-OXRL-0726-SM-3NM9A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40446
Vasculature-lymphatic endothelial cell	Tabula Sapiens Gene-Cell Associations	1.0	0.0987265
H3K36me3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_TGX-221_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0735021
CRCGN008_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32665
GSE85880,GSE85881_4_v_1_tretinoin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE163240_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_AZ 960_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0551351
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE140997_4_v_6_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
chlorpropamide-6291	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RWS6-1126-SM-47JXC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835755
A549_EED226_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0359528
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
A549_Baricitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0558359
GTEX-UJMC-1026-SM-4IHKN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97758
HMC18	DepMap CRISPR Gene Dependency	1.0	4.20071
GTEX-Q2AH-1726-SM-3NB2B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05056
GSE146982_3_v_2_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.884255
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TGFBR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17078
GSE221327_10_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
SCC-9	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.912681
GSE184356_1_v_2_tfam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CACO-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.14929
CEBPB	ENCODE Transcription Factor Targets	1.0	null
A549_Glesatinib(MGCD265)_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0800162
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843764
embryo	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CiliaryGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.877177
CRCGN016_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.04335
GTEX-QEL4-0326-SM-3GAE5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837341
A549_RG108_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0303516
GSE193351_1_v_0_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.40126
nb4	HPA Cell Line Gene Expression Profiles	-1.0	-1.05471
CRCGN016_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.18189
GTEX-PLZ5-0826-SM-3P5ZW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904241
A549_Tucidinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0364183
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Abexinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0519896
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
RERFLCSQ1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49708
GTEX-WEY5-1026-SM-4LMK9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.984902
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Tucidinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0651788
GTEX-PLZ5-1826-SM-3NB22	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22114
GSE147876,GSE147877_2_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Enzastaurin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.029075
trifluoperazine-4448	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-Q2AG-0326-SM-48U1O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52227
A549_BMS-536924_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0347884
GTEX-REY6-1426-SM-48FDK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13841
A549_PFI-1_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0344691
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC9170821-JCMM-26-3183-s001.xlsx-Endo_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
CAL27	DepMap CRISPR Gene Dependency	1.0	2.02656
A549_Streptozotocin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150675
A549_Crizotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0422148
NCI-N87	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
NOL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39986
GSE244518,GSE244520_1_v_0_dnmt3b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.15214
BICR78	DepMap CRISPR Gene Dependency	1.0	2.68569
A549_CYC116_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0442534
HOXD11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2943
SPTSSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93001
A549_Crizotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0796736
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12512
A549_Enzastaurin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.055992
GTEX-RTLS-0008-SM-48FET	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.992981
GTEX-PSDG-0526-SM-2S1OH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05643
kidney	HPA Tissue Gene Expression Profiles	1.0	0.878419
JHU-029	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ERVK3-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23131
GSE249098_1_v_0_mthfd1l_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_14101_KO_ARID1A_SRP355686	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.946398
EIF2S2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17373
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
A549_Fedratinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0607282
YY1	ENCODE Transcription Factor Targets	1.0	null
A549_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0353293
A549_Cyclocytidine HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199843
A549_Hesperadin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0264788
GSE96649_1_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.884255
A549_Ruxolitinib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0362782
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Anacardic Acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0522287
LS-513	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
A549_Rucaparib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0503358
A549_Prednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.049642
GI-ME-N	GDSC Cell Line Gene Expression Profiles	1.0	1.58082
A549_AMG-900_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017417
GSE146982_0_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
A549_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.070578
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
496100377_PCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.55631
A549_ZM 447439_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128131
GTEX-XMK1-1126-SM-4IHJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22833
SW1573	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
KLHL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42128
GTEX-PWCY-0826-SM-48TCR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86332
CRCGN013_HEPG2_24H:B07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.50544
A549_Thalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017798
SHSYSY+RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.33957
terconazole-4583	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Psoriasis 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.608
A549_PF-573228_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0539744
CRCGN016_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.7592
A549_GSK1070916_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.043132
A549_Costunolide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0347288
A549_Momelotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0395091
hsa-miR-4717-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
CRCGN016_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03291
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33386
hsa-miR-3171	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
A549_SNS-314 Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0261112
Skeletal Muscle Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-2.08759
hsa-miR-4751	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
MEWO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.90389
A549_AC480_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0445318
CRCGN011_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.20565
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857858
Glioma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN017_MCF10A.TP53.M_24H:K03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18889
hsa-miR-632	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
A549_SB431542_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0315929
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:O24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.23826
CRCGN016_MCF10A.TP53.M_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60491
NB7	DepMap CRISPR Gene Dependency	1.0	3.71496
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975101
hsa-miR-4699-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE229344_2_v_0_cyb5r3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242290_1_v_8_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MFSD14B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13709
GSE221327_1_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
cinnarizine-3175	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_Danusertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0231871
hsa-miR-1245	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
A549_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.040162
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29563
Alevin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.976
A549_Obatoclax Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.043667
GSE213228_4_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MDAMB415	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.855363
A549_EED226_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195849
GTEX-XOT4-0008-SM-4B664	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835391
CRCGN009_HEPG2_24H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.9625
GSE229580_2_v_1_creb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
LU134A	DepMap CRISPR Gene Dependency	1.0	2.63575
tanespimycin-5958	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_MC1568_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0407323
GSE149035_1_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Mercaptopurine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0377867
Salivary_Gland-endothelial cell of lymphatic vessel	Tabula Sapiens Gene-Cell Associations	1.0	0.557692
GSE111247_11_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
H3K79me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE221327_1_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
TCF12	ENCODE Transcription Factor Targets	1.0	null
A549_Panobinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0837455
Lymphnode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.937624
CRCGN016_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3106
GTEX-P4QS-0008-SM-48TDY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12245
A549_Curcumin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0640909
17389037-Tab2	GeneSigDB Published Gene Signatures	1.0	null
GSE213588_9_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GNB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15667
11-deoxy-16,16-dimethylprostaglandin E2-7538	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879194
GSE210101,GSE210114_2_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hsa-miR-3148	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
A549_AC480_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0480352
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.898332
NDUFS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26507
HSQ89	DepMap CRISPR Gene Dependency	1.0	4.4659
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K79me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN012_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3896
A549_Toremifene Citrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0606758
GTEX-XGQ4-1626-SM-4AT6J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36875
A549_ITSA-1_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0622266
A549_Dasatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195297
U251	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
A549_Abexinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0538543
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-300	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
fulvestrant-6867	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-UPK5-0008-SM-4IHJD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10593
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_WP1066_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0511096
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE227592_5_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Temsirolimus_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0253312
GSE140997_10_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.5386
GSE147626_2_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Tacedinaline_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0614246
PMC9950457-mmc3.xlsx-AP2A_binding_sites_GRHL2_KO-LRRC32_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0451733
pancreas	GTEx Tissue Gene Expression Profiles	-1.0	-0.870565
A549_JQ1_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0504156
CRCGN014_HEPG2_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48584
hsa-miR-106a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.895962
A549_Bisindolylmaleimide IX_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185444
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
KP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42289
A549_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0718806
A549_SRT3025 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0490038
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20393
A549_Rucaparib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.024507
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28418
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.24643
A549_Ruxolitinib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0791928
A549_Fasudil_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0632905
A549_Glesatinib(MGCD265)_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181741
WM88	CCLE Cell Line Gene CNV Profiles	1.0	3.02068
A549_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0353575
A549_PCI-34051_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0449336
hsa-miR-874	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
A549_Ivosidenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0388646
NCIH1648	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39185
A549_A-366_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0269061
SAOS2	DepMap CRISPR Gene Dependency	1.0	3.20567
CRCGN014_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.48114
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12681
HCC3153	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.1615
GTEX-P4PP-0426-SM-3NM9H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.957504
GSE207611,GSE207612_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC70	COSMIC Cell Line Gene Mutation Profiles	1.0	null
COX7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51053
A549_BRD4770_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0555267
Pasireotide (acetate)_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00859069
HUS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06186
GTEX-WRHU-0326-SM-3MJFY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32942
GTEX-WFG8-0008-SM-4LVN6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.977601
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_6471_KD_PER3_SRP371905	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.46156
CTCF_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_PD98059_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0714415
GTEX-T5JW-0008-SM-4DM5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06542
GSE233647_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE221327_1_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-OIZI-0226-SM-2XCEE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4697
hsa-miR-106b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
CRCGN015_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0276
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.976448
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240419
DNTTIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37829
A549_AG-490_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0538576
POLR2A	ENCODE Transcription Factor Targets	1.0	null
SUDS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37048
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GRPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.48296
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.74392
GTEX-XBEC-0326-SM-4AT4M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955282
A549_Selisistat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0706787
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
clozapine-1229	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Large intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.082
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-W5X1-2326-SM-3GIL6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89868
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-0.867181
GTEX-UPIC-0626-SM-4IHK2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5366
Perturb_16950_OE_GATA6_SRP235000	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.34259
KMRC1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.70469
GTEX-Q2AG-1226-SM-4GICA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52878
EB-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE221327_5_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Ofloxacin_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192211
hsa-miR-485-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
CRCGN008_HEPG2_24H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17155
A549_MLN8054_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165153
A549_Bosutinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0475239
CRCGN010_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.38125
A549_Tacedinaline_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0436572
GSE214931_1_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XQ3S-1426-SM-4BOPR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.014
GTEX-NL3G-0008-SM-4E3JX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.999645
esophagus_5c	HPA Tissue Sample Gene Expression Profiles	1.0	1.21018
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908134
DBTRG-05MG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Aurora A Inhibitor I_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171905
CYFIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19366
A549_Selisistat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0464289
A549_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0763236
u26684	HPA Cell Line Gene Expression Profiles	-1.0	-1.05471
GSE146982_0_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2392
GSE156923_0_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	1.0	null
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CSTF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19146
GSE193993_1_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TKQ2-1226-SM-4DXSV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69023
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3496
GTEX-RTLS-0226-SM-2TF5E	GTEx Tissue Sample Gene Expression Profiles	1.0	2.18532
CRCGN017_MCF10A.WT.HP_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7534
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27073
A549_Pracinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0393199
GSE178714_1_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851253
Perturb_6704_KD_LPA2_SRP057199	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.16332
Thymus-endothelial cell of lymphatic vessel	Tabula Sapiens Gene-Cell Associations	1.0	0.349628
A549_PCI-34051_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141339
A549_Ofloxacin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0434818
A549_AR-42_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0734736
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_SRT1720 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0420263
CRCGN016_MCF10A.TP53.M_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7889
KLF5	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE164874_5_v_8_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ethionamide-4593	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN012_HEPG2_24H:J20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1727
Esophagus - Muscularis	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.788167
A549_Divalproex Sodium_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0314572
fulvestrant-1205	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE173307,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.884255
VCAP	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FAM133B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09884
A549_Roxadustat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0469121
A549_ZM 447439_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188581
gonad	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
USF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
A549_Resminostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0229493
RAD21_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1428	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.817635
GM1600	BioGPS Cell Line Gene Expression Profiles	1.0	0.857093
hsa-miR-548c-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
CRCGN010_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.74003
GSE246660_1_v_0_glycerol_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0495948
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09551
hsa-miR-4308	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Seminal vesicle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.082
khos312h	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.651
496100494_HIP_no dementia_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.50184
H3K27me3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
23132-87	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_SNS-314 Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0269695
TCF7L2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7333
A549_Ki16425_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0362813
A549_Bisindolylmaleimide IX_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0482992
A549_AMG-900_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0379544
A549_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0732461
peroxisome	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nicolaides-Baraitser syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.534
A549_Tazemetostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0490975
GTEX-XUW1-1526-SM-4BOOY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54338
A549_Resminostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0461866
CRCGN015_MCF10A_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.1022
A549_Fasudil_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0371401
nicotinic acid-6702	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SNU-175	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
RXRA	ENCODE Transcription Factor Targets	1.0	null
GTEX-T6MN-0008-SM-4DM7H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
CRCGN012_HEPG2_24H:J19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20519
GTEX-PWOO-0008-SM-48TDU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30037
GSE160442,GSE160444_4_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0525054
esophagus_5b	HPA Tissue Sample Gene Expression Profiles	1.0	1.79185
CRCGN015_HEPG2_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.17272
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02301
A549_Hesperadin_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0308799
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A549_WP1066_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.041756
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.29195
GTEX-S3XE-1126-SM-4AD4N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853995
ONS76	CCLE Cell Line Gene CNV Profiles	1.0	1.54462
CRCGN015_HEPG2_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.77657
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-P4QR-0008-SM-48TE2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.964947
GSE184087_2_v_5_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PHETA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16258
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_Iniparib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150534
A549_Fedratinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.08251
A549_FLLL32_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0380471
GTEX-QDVJ-0826-SM-48U1S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01699
CLDN34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0251
A549_Lapatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0568884
GTEX-WXYG-0926-SM-3NB2O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23625
CRCGN008_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8721
A549_CYC116_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0426064
EB2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4P3-0008-SM-3NM8R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
SNU738	CCLE Cell Line Gene CNV Profiles	-1.0	-1.74413
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMD3-2326-SM-4AT5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.971063
hsa-miR-132	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GTEX-W5X1-2626-SM-4LMI8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90059
A549_AICAR_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0628528
chr9_42068051_C_G_b38	GTEx eQTL 2025	1.0	1.33578
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ABCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52679
domperidone-4640	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TrigeminalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.44367
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02583
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_Cerdulatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194515
TIMM22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29528
A549_MK-0752_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232363
H3K79me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
breast	GTEx Tissue Gene Expression Profiles	1.0	1.04844
chr9_42080196_C_T_b38	GTEx eQTL 2025	1.0	2.50657
A549_Trichostatin A_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0656027
A549_CUDC-101_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0723592
GTEX-XOTO-0226-SM-4B66H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11339
GTEX-OIZG-0008-SM-4E3J2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38442
A549_Pirarubicin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0473502
CRCGN011_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.4402
FDPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57522
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39554
OVCAR-4	GDSC Cell Line Gene Expression Profiles	-1.0	-1.77868
A549_Abexinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0611906
A549_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0800562
MEWO	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
SW1417	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN008_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.29475
TUBG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39878
A549_Alendronate sodium trihydrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0589131
CRCGN015_HEPG2_48H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.28251
A549_Pirarubicin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0548973
A549_Quercetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0767553
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.13958
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
496100472_PCx_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00154
HT-144	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-TKQ2-0008-SM-4DM5L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02603
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.05993
A549_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0472118
PMC5578490-pgen.1006879.s017.xlsx-Top_ETV1_downregulated_genes-Gene_Symbol_ETV1	Rummagene Transcription Factor Associations 2026	1.0	null
NR3C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1833
A549_Abexinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0610199
GSE142210_3_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33167
Perturb_3734_OE_CDO1_SRP119438	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE162892_3_v_2_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
MDA-MB-175-VII	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Toremifene Citrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0396205
PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_2-1769_genes_are_more_than_four-fold_upregulated_in_PRDM8-_-_compared_to_control_PRDM8	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OHPN-0008-SM-4E3HW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00476
GTEX-S95S-0008-SM-4AT5M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20188
PMC11749115-loae020_suppl_Supplementary_Table_S2.xlsx-CHOP-high-gene_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWSA-1326-SM-47JX9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17467
FOSL2	ENCODE Transcription Factor Targets	1.0	null
TFB2M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66235
A549_Barasertib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171014
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
20220088-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
hsa-miR-626	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
A549_Danusertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.042561
A549_Mocetinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0375393
CRCGN009_HEPG2_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.1528
GSE213228_4_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
testis	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE96777,GSE96778_3_v_2_zbtb4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3961
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBEW-1426-SM-4AT4J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17142
Liver-endothelial cell of hepatic sinusoid	Tabula Sapiens Gene-Cell Associations	1.0	0.276193
GSE206729_2_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE164874_5_v_10_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OHPM-0726-SM-3LK7A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14358
A549_Pelitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0431391
A549_SRT2104_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020407
CRCGN015_MCF10A.TP53.M_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.63495
A549_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0441448
GSE102505_1_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Avagacestat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195953
GTEX-POMQ-0008-SM-48TE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22341
GSE197555_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH1876	CCLE Cell Line Gene CNV Profiles	1.0	1.4077
GSE242199_6_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OR2A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12766
A549_Panobinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0394955
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE233679_6_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.2479
cefazolin-7385	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
D-245MG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Pelitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0886934
A549_Trichostatin A_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0531844
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5B-Up_H3K4me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SIU7-1326-SM-4BRWW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34306
A549_Linifanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184169
A549_Alendronate sodium trihydrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0515606
a549	HPA Cell Line Gene Expression Profiles	1.0	1.2074
GTEX-R55D-1526-SM-48FEJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856821
GSE152699,GSE152723_3_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_AG-14361_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0431885
A549_Triamcinolone Acetonide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0502859
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL2-Unnamed_0_TAL2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OC316	DepMap CRISPR Gene Dependency	1.0	3.76328
A549_Capecitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0379923
CEBPG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.664
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE129241_3_v_6_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE155972_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Tucidinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0481589
A549_PJ34_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0336533
GSE143994_2_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE108084_3_v_2_epinephrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Sodium Phenylbutyrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0321744
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
citalopram-4555	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE147893,GSE147897_2_v_1_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_MC1568_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0405326
GSE175787_11_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Aurora A Inhibitor I_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0242706
DNMT3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2842
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.97531
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.974732
CRCGN008_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.23195
GSE96649_1_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_Tie2 kinase inhibitor_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138424
A549_Linifanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0493032
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37398
GSE168587,GSE168752_3_v_1_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
(+)-isoprenaline-6663	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0314938
A549_Trametinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0744884
CRCGN009_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.20651
H3K27me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-OOBK-0008-SM-3NB27	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00108
A549_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0505456
SMC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10205
HCC1143	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.819838
A549_Resveratrol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0419463
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GSE216043_7_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE233679_14_v_9_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-NFK9-1226-SM-3LK79	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38721
GTEX-XQ3S-0008-SM-4GIDZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.289
(-)-MK-801-6657	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-4271	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GTEX-XMK1-2226-SM-4B673	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41484
PMC8185471-mmc4.xlsx-D2-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_2_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE94849_1_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Sodium Phenylbutyrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0776099
A549_M344_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0502806
A549_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0244301
GSE162892_3_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152734,GSE152735_2_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T2YK-2226-SM-32QPT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986306
A549_TMP195_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216885
A549_Maraviroc_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0347067
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MFE319	DepMap CRISPR Gene Dependency	1.0	2.39676
hsa-miR-1305	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
A549_Tofacitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.028736
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
QGP-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
UPCISCC029A	DepMap CRISPR Gene Dependency	1.0	2.50638
GTEX-WFON-1826-SM-3GILG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45349
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0510329
GSE148263_6_v_9_trim3_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SCC9	DepMap CRISPR Gene Dependency	1.0	2.57443
A549_Celecoxib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0680602
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4724-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GSE146982_0_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-335-5p	MiRTarBase microRNA Targets	1.0	null
GSE165307_2_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_ENMD-2076_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0279262
GSE160442,GSE160444_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-212	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
CRCGN014_HEPG2_3H:C06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03644
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17332
CRCGN012_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41377
GSE77108_6_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-450b-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.140752
A549_UNC0631_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178345
A549_GSK J1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0326724
SPIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.136
GTEX-RM2N-0626-SM-48FD6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67638
A549_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0291582
A549_Sodium Phenylbutyrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0362087
A549_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0488792
E2F7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1486
GSE146982_4_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.98039
A549_JQ1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0222147
A549_Mocetinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0459157
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
RMGI	DepMap CRISPR Gene Dependency	1.0	2.7246
cas1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.607
A549_TAK-901_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219992
Prostate-endothelial cell	Tabula Sapiens Gene-Cell Associations	1.0	0.569931
GSE229580_2_v_3_creb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
A549_Gandotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.025674
A549_Pracinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0734644
A549_MK-5108_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0492877
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880486
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.846615
proxymetacaine-5433	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN008_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3763
hsa-miR-543	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.70393
GTEX-RN64-0008-SM-48FEZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
hsa-miR-3682-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
A549_WP1066_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0297625
A549_Valproic acid sodium salt_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0596784
ampyrone-4507	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S7SF-0008-SM-3NM8T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
BL2266 (TDP1)	NURSA Protein Complexes	1.0	null
Gastrointestinal tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.082
A549_Amisulpride_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0450761
IGR-37	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Momelotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0381798
GTEX-TMZS-0226-SM-3DB9N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01209
A549_MC1568_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0632838
GSE207611,GSE207612_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_JQ1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0424343
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00373
JUND	ENCODE Transcription Factor Targets	1.0	null
GTEX-QCQG-0726-SM-48U1Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15641
SUPT5H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.1279
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.885287
hsa-miR-520g	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
A549_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0649215
A549_Tucidinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0303608
EEF1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03864
GSE138741,GSE138743_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE133087_5_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0563094
KARPAS-45	GDSC Cell Line Gene Expression Profiles	-1.0	-1.59869
hsa-miR-1253	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
A549_JNJ-26854165_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0455807
A549_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0512841
GSE178714_5_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OXRK-1426-SM-3NB19	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894744
GSE213588_9_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF616	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2875
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941161
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Busulfan_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0420081
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48038
FOXA2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPP1R11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04971
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NB1	CCLE Cell Line Gene CNV Profiles	1.0	1.44439
A549_Iniparib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.050042
CRCGN009_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.98395
GSE224742_0_v_1_slc1a5_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Raltitrexed_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0242309
A549_Navitoclax_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0546032
A549_Roxadustat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0394114
A549_Pelitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0505107
NCI-SNU-1	GDSC Cell Line Gene Expression Profiles	1.0	1.61692
A549_Triamcinolone Acetonide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0453809
A549_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151725
RIC8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19179
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04975
GSE211128_3_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U3ZH-1426-SM-4DXSR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04816
GSE169590_6_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_ABT-737_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.049502
GSE125011_0_v_2_cd83_human	RummaGEO Gene Perturbation Signatures	1.0	null
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-PWOO-1026-SM-48TCN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27706
GTEX-VUSG-0008-SM-4KL24	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
hsa-miR-520h	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
A549_Alisertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0577596
PANC-08-13	GDSC Cell Line Gene Expression Profiles	-1.0	-2.59975
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4309
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05269
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
T47D	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.867887
GSE153867_6_v_3_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0224
GSE149000_2_v_0_cyp3a5_human	RummaGEO Gene Perturbation Signatures	1.0	null
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC9509360-41419_2022_5262_MOESM6_ESM.xlsx-Fig_2D_MSC_targeted_RNF4-Down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Rucaparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0347003
CRCGN014_HEPG2_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.28429
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
hsa-miR-4282	TargetScan Predicted Conserved microRNA Targets	1.0	0.053794
Cervical adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.768
A549_Entinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0630822
A549_KW-2449_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0717001
GSE214248_0_v_1_cxcl8_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_PHA-680632_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172237
ZNF708	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0766
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
A549_Lapatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0338488
A549_SNS-314 Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0382246
GSE120612_6_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
TMEM229A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75062
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25616
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27733
CRCGN014_HEPG2_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48773
PMC10181932-41588_2023_1366_MOESM4_ESM.xlsx-Supplementary_Table_2-Supplementary_Table_2_Additional_information_for_all_SOX9-dependent_genes_SOX9	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Tozasertib_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163673
A549_Ramelteon_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0851041
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE207787_1_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K79me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S32W-1226-SM-4AD67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965625
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE235828_3_v_2_igf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PPP1R2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08745
A549_Selisistat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018754
GTEX-XQ3S-1226-SM-4BOPP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20728
PC-14	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
nes	HPA Cell Line Gene Expression Profiles	1.0	1.04755
EPLC-272H	GDSC Cell Line Gene Expression Profiles	1.0	1.69614
496100330_PCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.19327
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.885287
LIMK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12595
CL-34	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SYNCRIP_OE_GDS1886_83_human_THP-1 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-O5YV-0008-SM-4E3HP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825762
GTEX-WCDI-0008-SM-47JYE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
WM-115	GDSC Cell Line Gene Expression Profiles	1.0	2.01106
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0340918
NZM42	DepMap CRISPR Gene Dependency	1.0	2.33304
A549_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0343504
GSE206342_1_v_0_kpna2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_MK-0752_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0383979
A549_2-Methoxyestradiol_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132516
GTEX-U8XE-1826-SM-4E3HV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0912
A549_JNJ-26854165_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0262921
A549_FLLL32_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.030138
GTEX-X5EB-0008-SM-46MU3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.94893
A549_Givinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.024324
GTEX-O5YV-0226-SM-48TBY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.8616
A549_Obatoclax Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0504227
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Alisertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0566303
GSE233679_5_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178218
A549_Tozasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212063
A549_Crizotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0569717
GTEX-U3ZN-1926-SM-4DXSG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.885928
H3K9ac_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-T2IS-0226-SM-32QPH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95914
A549_Cerdulatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194293
GSE214931_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Aurora A Inhibitor I_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0593402
A549_Thiotepa_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0854245
GTEX-WEY5-0008-SM-4LMKC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.854511
GTEX-QDT8-0326-SM-32PL1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962539
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE232714_0_v_1_raver1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE219274,GSE219276_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-NPJ8-0226-SM-48TBN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834085
TMD8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.75667
A549_Capecitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185294
quipazine-5887	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BICR78	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_8477_KO_FMR1_SRP154204	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE128730_4_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.06338
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.985877
astrocytoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MYBL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9814
A549_Azacitidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0592082
GTEX-U8XE-0005-SM-3DB8I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4693-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
A549_PFI-1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0535922
hsa-miR-4251	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
L363	DepMap CRISPR Gene Dependency	1.0	3.69506
GTEX-WXYG-2226-SM-4E3IM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13162
CRCGN015_MCF10A_48H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09769
GSE205163,GSE205164_9_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0316854
MONO-MAC-6	GDSC Cell Line Gene Expression Profiles	-1.0	-1.60384
A549_Resveratrol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0611494
CTCF_epithelial cell of proximal tubule_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46573
PMC9170821-JCMM-26-3183-s001.xlsx-Neu_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
496100357_TCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.92362
HEK 293 T-rex    	BioGPS Cell Line Gene Expression Profiles	1.0	0.947481
GSE229973_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.414
NCIH196	CCLE Cell Line Gene CNV Profiles	-1.0	-1.62735
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE121043_0_v_1_aldh1a1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NZOV9	DepMap CRISPR Gene Dependency	1.0	4.02567
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
Cells - Cultured fibroblasts	GTEx Tissue Gene Expression Profiles 2023	1.0	3.6968
CRCGN013_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31915
phenelzine-4538	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RU72-2226-SM-46MUE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05904
A549_Abexinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159241
18338247-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
CRCGN015_HEPG2_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.31503
A549_Trichostatin A_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0252945
CRCGN014_HEPG2_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.63015
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
GSE158182_5_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE106661,GSE106665_0_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0401809
A549_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0706556
KMBC2	CCLE Cell Line Gene CNV Profiles	1.0	1.34725
GTEX-POYW-0008-SM-48TE4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03103
SARS-BatSRBD_0Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.21163
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33167
PCI30	DepMap CRISPR Gene Dependency	1.0	3.27878
GTEX-XXEK-0426-SM-4BRVW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38096
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.67391
GTEX-S3XE-1626-SM-3K2AJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1749
A549_FLLL32_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0402349
S-117	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
GTEX-W5WG-1526-SM-4LMIG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869247
A549_ZM 447439_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196654
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.911489
ganciclovir-3368	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4422	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
PMC12518476-10067_2025_7574_MOESM9_ESM.xlsx-Sheet4-RNAseq_SJIA_KD_up_inter_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
chr9_42002955_T_C_b38	GTEx eQTL 2025	1.0	1.5583
GTEX-XOT4-0226-SM-4B66Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877355
A549_Vandetanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0634189
RPP38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75424
GTEX-WH7G-0008-SM-4LVNM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18658
GTEX-XPVG-2726-SM-4B66W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06898
A549_Bosutinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0510915
BOP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0279
(-)-atenolol-6725	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
A549_Carmofur_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185531
SUM1315MO2	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.825904
ethaverine-6737	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE264010_0_v_1_parp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T6MO-0626-SM-4DM6P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828006
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF214	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0922
A549_G007-LK_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0710554
H3K27me3_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOS	ENCODE Transcription Factor Targets	1.0	null
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2565
CRCGN015_MCF10A_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.5678
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
A549_ABT-737_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175527
A549_Capecitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0507258
adult retina	HPM Cell Type and Tissue Protein Expression Profiles	1.0	1.14787
A549_Tranylcypromine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170741
GTEX-NPJ8-0011-R6a-SM-2HMKB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845576
A549_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197535
GSE137702_2_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
TR146	DepMap CRISPR Gene Dependency	1.0	3.26526
PMC7455079-jciinsight-5-140380-s227.xlsx-Supp_Table_9-Supplemental_Table_9_Limma_DE_Analysis_of_HC_AA_to_EA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R55C-0726-SM-48FCN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51841
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_SRT3025 HCl_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141979
KINGS1	DepMap CRISPR Gene Dependency	1.0	2.88247
H9 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.868286
H-7-5941	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XUZC-0526-SM-4BOPF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17271
hsa-miR-2467-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.884255
GTEX-WFG7-0008-SM-4LMKB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
SARS-dORF6_36Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.1861
PORCN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54394
PANC1	BioGPS Cell Line Gene Expression Profiles	1.0	1.0603
A549_Daphnetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0342865
CRCGN016_MCF10A.TP53.M_24H:F11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12619
NKM-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_2-Methoxyestradiol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0570973
A549_SRT2104_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0449771
CRCGN010_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23813
A549_Daphnetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0567748
CRCGN009_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.1374
NUP88	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4519
CRCGN013_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.56695
CRCGN013_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48611
bromopride-3719	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE178907_4_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NUDHL1	CCLE Cell Line Gene CNV Profiles	1.0	1.35442
sulfanilamide-4474	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE87617_1_v_0_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_PCI-34051_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0428611
GTEX-Q2AG-0226-SM-2S1P4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944055
H3K4me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
astroglial cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_CUDC-907_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0684286
GTEX-R55E-0006-SM-2TC5G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
HCC1937	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.702635
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SIU8-0226-SM-2XCDS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.862517
A549_ZM 447439_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0695032
COLO-684	GDSC Cell Line Gene Expression Profiles	1.0	1.42844
GSE218727_2_v_1_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
19139136-TableS3	GeneSigDB Published Gene Signatures	1.0	null
A549_Epothilone A_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0296426
A549_Danusertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0272713
A549_Vandetanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0526859
valproic acid_homo sapiens_gpl6244_gse23909	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
GSE235701,GSE261434_2_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.93625
CRCGN015_HEPG2_48H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.52051
CTCF_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prestwick-1100-4534	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-519a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
A549_CEP-33779_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0530079
A549_Cimetidine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0340674
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17152
CRCGN012_HEPG2_24H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12885
A549_Rigosertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0612338
496100518_HIP_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.14678
GTEX-SNOS-0008-SM-4DM6I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.910871
lytic vacuole	LOCATE Predicted Protein Localization Annotations	1.0	null
TIMM23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02401
CRCGN014_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7248
stomach_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.988519
A549_SGI-1776 free base_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223943
GTEX-SNMC-0626-SM-4DM6H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841402
A549_Tacedinaline_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.066895
CD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47662
RFX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75216
esophagus	GTEx Tissue Gene Expression Profiles	1.0	1.28238
GSE147366_3_v_5_med13_human	RummaGEO Gene Perturbation Signatures	1.0	null
gentamicin-5883	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-UJMC-0008-SM-4IHKK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08345
GSE77108_0_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.84255
A549_UNC0379_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0418281
H3255	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
laminin-10 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.559
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RM2N-1726-SM-2TF55	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903851
A549_Patupilone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0524813
A549_RG108_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0296088
sulfamonomethoxine-5843	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
COLO 794	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.948116
hsa-miR-922	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10028
hsa-miR-557	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
colon_8a	HPA Tissue Sample Gene Expression Profiles	1.0	1.0932
testicular cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H2BC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13258
A-Vietnam-1203-2004(H5N1)_24Hour_None_GSE43204	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.57205
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BT20	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.9433
A549_Azacitidine_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0478065
Perturb_8305_KO_GALNT1_ERP012063	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.31169
GSE171572_3_v_4_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U3ZN-1826-SM-4DXUY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53499
GTEX-W5X1-2826-SM-3GILM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02883
GSE229671,GSE229673_2_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.82836
GTEX-QDVN-1126-SM-48TZ7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31551
hsa-miR-20b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GSE210476_9_v_4_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Filgotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.07501
A549_Mesna_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0624577
A549_Aminoglutethimide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0285316
R-atenolol-4259	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN008_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7546
GTEX-VUSG-0626-SM-4KL1Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830201
LOVO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE221327_1_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
FADU	CCLE Cell Line Gene CNV Profiles	-1.0	-2.48894
chlorhexidine-6302	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_FLLL32_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0360702
TOV112D	CCLE Cell Line Gene CNV Profiles	-1.0	-1.81948
A549_CUDC-907_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0551767
GSE201877_1_v_0_yap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T2YK-0005-SM-32QOV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83903
A549_G007-LK_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.054815
SW1573	CCLE Cell Line Gene CNV Profiles	-1.0	-2.36133
GSE258991_5_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NFKB1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
CHAGOK1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39051
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-130b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
A549_Luminespib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0481574
CRCGN015_HEPG2_48H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.24561
GSE146982_3_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SKNFI	CCLE Cell Line Gene CNV Profiles	1.0	2.26626
GSE175787_4_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Lapatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193758
benserazide-6482	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_Amisulpride_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0455774
CRCGN015_MCF10A_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1056
GSE223241_1_v_3_cdkn2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
GSE206226_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WCDI-0002-SM-3P61U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
GTEX-TKQ1-1126-SM-4GIAZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31581
GSE211128_4_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RXRA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_ENMD-2076_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0275567
A549_Alisertib_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0390163
496100612_HIP_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04279
GTEX-TML8-1426-SM-4DXUT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15138
C16orf87	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49702
A549_Selisistat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0651109
A549_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0654939
CRCGN009_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10428
PMC7260947-pnas.1912355117.sd02.xlsx-Sheet1-1185_common_genes_in_D_E_genes_KD_and_AcAPE1_ACOGG1_G4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Fasudil_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0568533
PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Unnamed_4_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
496100452_HIP_possible Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.49549
GTEX-WFJO-0008-SM-4LVN7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963444
GTEX-U3ZN-0526-SM-4DXTH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03008
A549_Nintedanib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0429003
A549_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0374329
A549_JQ1_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0279576
OVCAR-4	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
GSE211128_4_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Breast hyperplasia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.982
glia	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SNU1066	DepMap CRISPR Gene Dependency	1.0	2.49787
A549_AC480_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0818929
CYP26A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34735
CRCGN014_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0428
A549_Cimetidine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0383419
ZNF260	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09985
CRCGN017_MCF10A.TP53.M_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.22225
MCRS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47497
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE165636_0_v_4_tofacitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH82	CCLE Cell Line Gene CNV Profiles	-1.0	-2.07628
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36428
GSE147366_3_v_2_med13_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PSDG-0326-SM-48TCP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14624
A549_Pracinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.048527
NCI-H23	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Decitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.049165
A549_Avagacestat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0601002
A549_SRT1720 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0415427
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE233679_5_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE165307_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SW13	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
A549_SGI-1776 free base_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0657303
GTEX-XK95-0426-SM-4AT4R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01812
NCIH441	DepMap CRISPR Gene Dependency	1.0	2.08135
A549_Gandotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0500611
A549_PFI-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0503678
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14689
KP-N-YS	GDSC Cell Line Gene Expression Profiles	-1.0	-1.72899
TIMM23B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74973
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
glial cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-V1D1-1226-SM-4JBI5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935335
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE206226_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Leukemialymphoblastic(MOLT-4)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.12253
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
A549_BMS-265246_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0357294
GSE118816_2_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_JNJ-7706621_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207684
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-1296	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
A549_2-Methoxyestradiol_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0235412
A549_Meprednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0499522
A549_SRT3025 HCl_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188998
GTEX-PSDG-1626-SM-48TCQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938602
A549_Hesperadin_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0562249
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1435	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Dacinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0729224
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_BMS-911543_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.038369
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0622149
KAT2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58563
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XXEK-0526-SM-4BRWD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1941
GTEX-UPJH-0926-SM-4IHKA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909482
CRCGN009_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1812
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
VA-ES-BJ	GDSC Cell Line Gene Expression Profiles	1.0	1.65095
A549_Costunolide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0368757
A549_G007-LK_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.048819
RNF113A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35984
hsa-miR-381	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
A549_SRT2104_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0310838
GPR50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41605
A549_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0226383
CFPAC1	DepMap CRISPR Gene Dependency	1.0	2.76227
A549_Curcumin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0436665
A549_MLN8054_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0694595
GTEX-PWN1-0726-SM-48TDR	GTEx Tissue Sample Gene Expression Profiles	1.0	2.53488
GSE125014_6_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.885287
PMC9899501-NIHMS1869252-supplement-Table_S4.xlsx-REACTOME_DOWN_2_5-PAX3_PAX3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.871011
KD	DepMap CRISPR Gene Dependency	1.0	3.24209
GTEX-RU1J-0008-SM-46MV9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16031
A549_Droxinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0225949
FOXA2	ENCODE Transcription Factor Targets	1.0	null
A549_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.079141
valproic acid-1214	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PAX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3573
INCENP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39651
NCIH1930	CCLE Cell Line Gene CNV Profiles	1.0	1.49883
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G70994MS	GlyGen Glycosylated Proteins	1.0	null
NR3C1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
A549_Belinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.053463
A549_Resveratrol_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167545
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981881
GSE221327_4_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_GSK1070916_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0383727
CRCGN017_MCF10A.WT.HP_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.51827
A549_Tranylcypromine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0524051
hsa-miR-520d-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.37496
CRCGN010_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7057
CRCGN017_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47255
A549_Abexinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0611563
GTEX-UPJH-0326-SM-3GADU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987479
OUMS23	DepMap CRISPR Gene Dependency	1.0	2.44083
DCPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50074
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.011
GTEX-TKQ2-1826-SM-33HB2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.960668
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09551
GSE238005_5_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
GTEX-OIZI-1126-SM-3NB1F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967154
SW1088	GDSC Cell Line Gene Expression Profiles	1.0	1.47811
GSE134029_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4295	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
A549_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0620352
A549_PJ34_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0237871
GSE147876,GSE147877_2_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE221327_8_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Luminespib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0595566
GTEX-XMD1-0008-SM-4AT41	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
A549_TMP195_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0221546
A549_Cediranib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0299125
GTEX-U8XE-0008-SM-4E3K4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05734
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
GSE93124_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SKG-IIIA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-548f	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
PMC8507136-12935_2021_2224_MOESM5_ESM.xlsx-CREB1_upregulated_RRHO_list-Unnamed_35_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7452
SF3A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12454
astrocyte	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN009_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.38125
GTEX-X5EB-2426-SM-4E3HX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83249
GSE193351_1_v_2_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
fluphenazine-5880	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QVJO-1826-SM-447C9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9329
GTEX-QMRM-0926-SM-447BR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15853
A549_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0317917
A549_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0695437
A549_Ellagic acid_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131424
A549_PD173074_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0549371
CRCGN009_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4491
TGFB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5204
GSE122425_1_v_0_nsun2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-26b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GSE175787_13_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
NO-10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-152	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
496100350_FWM_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.42517
A549_Rucaparib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0352962
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
aminophenazone-4481	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE147876,GSE147877_4_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177763
A549_INO-1001_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165794
CRCGN008_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.98965
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
A549_JNJ-7706621_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0496047
hsa-miR-4446-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE131649_6_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_MC1568_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0539692
VEZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54708
TT2609-C02	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Fasudil_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.05645
A549_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0710441
GTEX-R55G-0926-SM-48FDN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21756
GSE193541_0_v_3_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Panobinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200861
SNAI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6686
A549_AZ 960_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0499461
A549_Sorafenib Tosylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0637161
A549_Azacitidine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0535921
GSE211262,GSE211263_2_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWS6-2326-SM-2XCB4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899845
embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_ITSA-1_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0461417
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83953
CTCF_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Tanespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0363248
GTEX-QDT8-0008-SM-48U2F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21232
AP1S2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09593
A549_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.100455
A549_SRT2104_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0486925
GTEX-T6MO-0008-SM-4DM6T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932961
A549_Belinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0596632
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EFO27	DepMap CRISPR Gene Dependency	1.0	4.2418
GSE192870_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Tofacitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0492182
hsa-miR-4288	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
A549_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0290069
A549_Disulfiram_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0594501
GTEX-UPJH-0626-SM-4IHJN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941978
A549_PF-3845_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0282038
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14701
A549_SNS-314 Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0747756
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14004
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214931_4_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DBTRG-05MG	GDSC Cell Line Gene Expression Profiles	1.0	2.33041
CRCGN015_HEPG2_48H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4588
A549_Veliparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0244296
A549_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0326143
SK-N-FI	COSMIC Cell Line Gene CNV Profiles	1.0	2.15892
A549_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0326806
SARS-CoV_12Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.80774
HS-445	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NUGC2	CCLE Cell Line Gene CNV Profiles	1.0	2.18004
A549_BMS-911543_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0654884
GTEX-SJXC-0008-SM-4DM7G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15621
fluoxetine-6757	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0748463
SDHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43451
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.31575
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Supplementary_Table_2F_Contrast_ATF4-def_IGG_8h_vs_HCT116_IGG_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QMR6-0011-R6A-SM-32PKP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0344
sisomicin-2853	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XV7Q-1226-SM-4BRVT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57496
Progressive familial heart block	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
GTEX-WYVS-1726-SM-3NMAY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919076
GTEX-W5WG-0008-SM-4KL25	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.878973
GSE106661,GSE106665_2_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Ruxolitinib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0993983
SU-DHL-1	GDSC Cell Line Gene Expression Profiles	-1.0	-2.08455
EOGT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15714
A549_ABT-737_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167588
TP63-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
ME-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NY	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
A549_CEP-33779_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0719417
HCC1937	CCLE Cell Line Gene CNV Profiles	1.0	2.02692
CTCF_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBM41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50207
A549_Flavopiridol HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232099
GSE146982_4_v_2_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_CUDC-101_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0283558
A549_Maraviroc_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0559811
Intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.082
SNUC1	DepMap CRISPR Gene Dependency	1.0	2.0274
NCIH1915	DepMap CRISPR Gene Dependency	1.0	2.20527
GTEX-UJHI-0926-SM-4IHKF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63836
A549_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0257688
GTEX-V1D1-0726-SM-4JBH7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01847
MN-60	GDSC Cell Line Gene Expression Profiles	-1.0	-1.74348
GTEX-U3ZH-1126-SM-4DXUG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.98088
GSE240030,GSE252532_0_v_2_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.034
GSE118490_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Fetallung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.951197
A549_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0368966
A549_S-Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0226198
icSARS CoV_12Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-0.78872
COLO680N	CCLE Cell Line Gene CNV Profiles	1.0	2.58539
EC-GI-10	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
JIYOYEP-2003	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XYKS-0008-SM-4BRW6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17023
hsa-miR-3157-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
hsa-miR-26a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.162461
A549_SGI-1776 free base_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.011552
TAF1	ENCODE Transcription Factor Targets	1.0	null
TE-441-T	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
GTEX-XOTO-0126-SM-4B66N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18995
CTCF_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Dasatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.025599
SIHA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.918546
GTEX-VUSG-2626-SM-4KKZI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05036
NCVADR RES	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.990556
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05269
A549_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0239208
GSE140997_2_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-4446-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
A549_Valproic acid sodium salt_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0323156
CRCGN017_MCF10A.WT.HP_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2078
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
GTEX-PLZ4-0008-SM-48TE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.993973
A549_WHI-P154_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0487519
GTEX-RWS6-0426-SM-47JXH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
A549_PFI-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0291001
SMYD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58775
GSE48812_9_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE207471_2_v_3_btla_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Cimetidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0439491
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892983
hsa-miR-22	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
FADU	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
GTEX-S4P3-1326-SM-4AD6V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02866
PMC12518476-10067_2025_7574_MOESM9_ESM.xlsx-Sheet3-RNAseq_SJIA_KD_inter_AR	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-323b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE146982_4_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XUW1-2326-SM-4BOO5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83905
Perturb_6847_KO_PHGDH_SRP261092	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.8526
CRCGN015_HEPG2_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.71699
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Supplementary_Table_2B_Contrast_ATF4-def_DMSO_2h_vs_HCT116_DMSO_2h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
ATG14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51414
A549_Belinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0752286
A549_EED226_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0383228
CRCGN011_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.82355
CHD1	ENCODE Transcription Factor Targets	1.0	null
TFAP2C	JASPAR Predicted Transcription Factor Targets	1.0	null
hsa-miR-519d	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1339	CCLE Cell Line Gene CNV Profiles	-1.0	-1.76873
hsa-miR-1269	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
SIN3A	ENCODE Transcription Factor Targets	1.0	null
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G-401	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.997501
A549_Tazemetostat_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0622167
A549_Patupilone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.029331
ZNF428	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9057
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO680N	DepMap CRISPR Gene Dependency	1.0	5.74572
PMC12518476-10067_2025_7574_MOESM9_ESM.xlsx-Sheet2-RNAseq_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QEG5-0426-SM-2I5GJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17463
GTEX-XUW1-1326-SM-4BOO1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47148
A549_PD98059_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.050041
GSE155800_1_v_0_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17572
A549_M344_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0554197
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.58449
PL45	CCLE Cell Line Gene CNV Profiles	1.0	1.43635
GSE213588_9_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9392
male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE142210_3_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_SRT2104_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0277792
A549_SRT2104_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187458
GTEX-X5EB-1426-SM-46MVW	GTEx Tissue Sample Gene Expression Profiles	1.0	2.25279
A549_Aminoglutethimide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0345989
A549_Decitabine_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196487
CRCGN016_MCF10A.TP53.M_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62735
adipose tissue	GTEx Tissue Gene Expression Profiles	1.0	0.925037
GSE228106_3_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
A549_M344_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0421399
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE191015_0_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147626_2_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH647	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32635
GTEX-SNMC-0126-SM-2XCFO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03566
A549_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0369726
FOXA2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PNO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11234
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.943429
A549_EED226_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0515143
glioma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
dicoumarol-3941	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE205976,GSE205978_1_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Givinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0603283
RRN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.88206
A549_Roscovitine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0334281
hsa-miR-548a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
PMC9068765-41467_2022_29960_MOESM14_ESM.xlsx-TP53-Annotation_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
PA-TU-8988T	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HCC2998	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_GM13977_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148657_2_v_1_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8499
A549_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0259025
A549_CYC116_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0442525
A549_ITSA-1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.044502
PMC4595011-pgen.1005555.s003.xlsx-MITF_DOWN-regulated-Gene_name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE211128_3_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0413099
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE209582_1_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Glesatinib(MGCD265)_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135101
SCN4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18705
A549_Raltitrexed_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0361911
A549_Entinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0451646
hsa-miR-4793-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
A549_Thiotepa_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0370319
GTEX-NL3H-0008-SM-4E3HU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
PMEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59072
MM253	DepMap CRISPR Gene Dependency	1.0	2.76957
HCC2998	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.18839
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Meprednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0462061
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_MK-5108_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0625084
Chronic closed-angle glaucoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
GTEX-V1D1-2626-SM-4JBJH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865994
Nonspecific interstitial pneumonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
A549_CUDC-101_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0598457
CRCGN016_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.27975
hsa-miR-93	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
CRCGN017_MCF10A.WT.HP_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.8236
GTEX-OIZH-0726-SM-3NB1I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853553
TOV-112D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HCC70	CCLE Cell Line Gene CNV Profiles	1.0	1.90237
GTEX-UTHO-0008-SM-4JBID	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.992862
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN013_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.10303
monorden-4443	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
kidney_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.80586
GSE175787_5_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ECC10	CCLE Cell Line Gene CNV Profiles	1.0	1.5701
GTEX-TML8-0008-SM-4DXUI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00335
A549_BMS-536924_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210003
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.848332
CRCGN017_MCF10A.WT.HP_24H:E04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.94119
A549_PJ34_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0470432
CRCGN017_MCF10A.WT.HP_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1432
hsa-miR-3065-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
USF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_ITSA-1_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0482065
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_AR-42_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0432899
thyroid_5c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.40844
ACHN	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.26515
TCF12_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
chr9_42143655_C_T_b38	GTEx eQTL 2025	1.0	1.73003
A549_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0798903
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.884255
GSE218949_0_v_1_cep20_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Givinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0247867
GTEX-RUSQ-0926-SM-47JWU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07614
NCI-H1688	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_JQ1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0515881
GTEX-TML8-1226-SM-32QON	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881803
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
AICD_Induced  expression / Over-expression_GDS1979_288_human_SHEP-SF neuroblastoma	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
17880687-TableS3	GeneSigDB Published Gene Signatures	1.0	null
A549_Tazemetostat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0862426
CRCGN011_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0062
GTEX-QDT8-0226-SM-32PL4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09683
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S3XE-0626-SM-4AD6B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844255
HCC1419	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.70593
A549_S3I-201_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0600885
A549_PFI-1_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0579864
GTEX-S4P3-0526-SM-4AD58	GTEx Tissue Sample Gene Expression Profiles	1.0	2.13369
CRCGN008_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7989
GTEX-WFG8-2326-SM-3GILF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844232
CRCGN017_MCF10A.TP53.M_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.64616
A549_MC1568_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0507722
A549_Fasudil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0321
A549_Alisertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0607688
GSE125219,GSE125221_4_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.21265
hsa-miR-4778-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Ciliary epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.523
Perturb_17147_OE_RHOC_SRP190501	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
C-33-A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MKN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05269
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_CUDC-101_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.049199
CRCGN017_MCF10A.WT.HP_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9677
GTEX-S4Q7-0008-SM-3NM8A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34352
placenta_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.10546
A549_AR-42_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0366917
A549_Zileuton_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188785
JUND_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN011_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7505
GSE221327_6_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-4675	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
A549_Triamcinolone Acetonide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0566392
A549_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0484976
A549_Tranylcypromine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0248818
GTEX-T8EM-0626-SM-4DM62	GTEx Tissue Sample Gene Expression Profiles	1.0	2.23803
azacyclonol-6298	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE153867_6_v_8_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN014_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.39375
CRCGN008_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3486
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Supplementary_Table_2A_Contrast_ATF4-def_control_vs_HCT116_control_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
WDR33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06271
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23679
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-TKQ1-0426-SM-4DXT4	GTEx Tissue Sample Gene Expression Profiles	1.0	2.70699
HCC1419	CCLE Cell Line Gene CNV Profiles	-1.0	-1.76851
A549_Dacinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.032469
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13393
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.846615
astrocytes	BioGPS Cell Line Gene Expression Profiles	1.0	1.20792
A549_Azacitidine_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.013534
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ciliary muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.698
A549_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0233074
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPU-2226-SM-2XCAQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923816
GTEX-P4PP-0726-SM-3NM9S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89181
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
macroglia	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hsa-miR-1297	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
A549_BMS-911543_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0391368
GTEX-WFG8-1026-SM-4LVMZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44805
A549_UNC1999_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0560232
P31-FUJ	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
NCI-H1648	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
hsa-miR-371-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Hesperadin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0459816
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.43215
GSE233679_6_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195568_3_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0239065
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
Perturb_6849_KO_PRE2_SRP273076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.29769
GSE89057_0_v_1_sox5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nerve - Tibial	GTEx Tissue Gene Expression Profiles 2023	1.0	2.97296
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE140997_4_v_3_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37747
GTEX-XYKS-1726-SM-4E3IO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88727
A549_S3I-201_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0252957
EBC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.69841
A549_Regorafenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0596177
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
chr9_42136616_G_T_b38	GTEx eQTL 2025	1.0	2.11788
MZ7-MEL	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
CRCGN015_MCF10A_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.57672
A549_Roxadustat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204227
A549_JNJ-7706621_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0416157
18338247-SuppTable4B	GeneSigDB Published Gene Signatures	1.0	null
GTEX-XUJ4-1126-SM-4BOPC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18322
A549_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177236
Perturb_8306_KO_GALNT2_ERP012063	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.33734
NCI-H250	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Ki8751_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0409265
A549_ENMD-2076 L-Tartaric acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124451
A549_Daphnetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0389793
A549_Navitoclax_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0265364
A549_Abexinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.041144
GTEX-NL3H-0011-R11A-SM-2I3E6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842766
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RTLS-1226-SM-46MUP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52859
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U8T8-0008-SM-4DXSP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911421
NCIH3255	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51321
496100487_HIP_probable Alzheimer's disease_no TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.20875
NUGC-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.91552
GSE68229_0_v_1_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A549_Alendronate sodium trihydrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0498676
A549_AZD1480_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0560045
chr9_42171656_A_T_b38	GTEx eQTL 2025	1.0	1.04204
GTEX-S95S-0326-SM-4B66U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82663
A549_SB431542_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0310205
KLE	COSMIC Cell Line Gene Mutation Profiles	1.0	null
IL15_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
Myxofibrosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
MRS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09854
A549_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0273435
GTEX-U4B1-0008-SM-4DXUW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.891855
MRPS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01231
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE193351_1_v_3_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_TGX-221_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0651932
A549_Entacapone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.028976
496100463_FWM_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.12286
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
KARPAS-422	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-SE5C-0326-SM-4BRWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12636
RKN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.968409
A549_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0490309
A549_Lenalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0695445
GSE131649_6_v_0_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Nintedanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0412473
A549_Maraviroc_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0357783
A549_Ki16425_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0721782
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.922342
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_12_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PVOW-0011-R1A-SM-32PL6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83187
A549_BMS-536924_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0323018
A549_IOX2_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0301626
CRCGN011_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43165
A549_Selisistat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0555412
ovary_8a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.14361
SK-MEL-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.31543
GSE146982_7_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.15745
A549_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0771393
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11884
A549_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0300328
A549_CEP-33779_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178734
hsa-miR-2682	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
BT549	CCLE Cell Line Gene CNV Profiles	1.0	1.9284
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975217
A549_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0330821
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDT8-1026-SM-43V6X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843196
RBBP5	ENCODE Transcription Factor Targets	1.0	null
A549_TMP195_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0384826
B4GALT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40567
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17853
hsa-miR-371b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GSE191021_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Streptozotocin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0372013
GTEX-RWSA-0226-SM-2XCBA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13615
SLF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2663
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMRC-1	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
neomycin-5867	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ASH-3	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
BHT-101	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
A549_Regorafenib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0516648
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE140997_2_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC38	CCLE Cell Line Gene CNV Profiles	1.0	1.58788
NCIH1975	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7196
BRD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05914
BT12	DepMap CRISPR Gene Dependency	1.0	3.42733
CRCGN017_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37914
GTEX-QV44-1825-SM-447CF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03666
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Brain - Nucleus accumbens (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.13143
felodipine-6695	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XOT4-1126-SM-4B66E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90811
GTEX-QDT8-1326-SM-48TYY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67566
GTEX-S7SF-1026-SM-4AD4I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97886
GSE202434,GSE202438_9_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SK-BR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05933
GTEX-N7MS-0011-R11A-SM-2HMJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23056
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
496100281_HIP_probable Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.13668
VMRC-LCD	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WFG8-1126-SM-4LVN1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68334
endoplasmic reticulum	LOCATE Predicted Protein Localization Annotations	1.0	null
SIG-M5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WFON-1526-SM-4LVMP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8766
GTEX-R3RS-0008-SM-48FF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1485
A549_Belinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140729
GTEX-PVOW-0008-SM-48TE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1737
CRCGN017_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.01705
BICR 78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27562
GSE238018_1_v_5_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
khos/np	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.158
CRCGN014_HEPG2_24H:D13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.32773
GTEX-RNOR-0008-SM-48FEY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889344
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7374
CRCGN009_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.88918
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_PHA-680632_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181522
SHMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52405
GTEX-XMK1-1826-SM-4B66F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19658
GTEX-WEY5-1126-SM-4LMIE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11109
A549_UNC1999_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218744
A549_JNJ-7706621_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.053949
SARS-BatSRBD_84Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.75838
GTEX-R53T-1526-SM-48FEK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17523
A549_BRD4770_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0230038
TFG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13898
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X5EB-1026-SM-46MVU	GTEx Tissue Sample Gene Expression Profiles	1.0	2.64158
GSE229973_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A253	CCLE Cell Line Gene CNV Profiles	1.0	1.83406
A549_Tubastatin A HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0451068
A549_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.059884
A549_Alisertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0355455
NK-92MI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02001
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11315
A549_Streptozotocin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0614656
H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE233679_14_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-C_ATF4-def_vs_HCT116_DMSO8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN010_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46766
GTEX-XBEW-1526-SM-4AT4K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941865
GSE196117_6_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-3121-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
A549_Quisinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0534372
A549_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.053687
A549_PF-3845_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0721014
A549_Crizotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173744
GTEX-QV44-1026-SM-447CG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57664
GTEX-PWCY-0008-SM-48TE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN010_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.59334
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26926
A549_Fluorouracil_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0525314
GSE146982_4_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4649-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GSE214931_1_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H1299	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
A549_Divalproex Sodium_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0393192
GTEX-XMK1-0926-SM-4B66X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30451
A-Vietnam-1203-2004(H5N1)_7Hour_21865398_GSE28166	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.60457
GTEX-X4XY-0326-SM-46MVZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962871
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.05324
CRCGN014_HEPG2_24H:N08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28009
EXOC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24504
PMC11465086-mmc2.xlsx-Table_ES_1_markers_c0_LPS_Vs_Co-Gene_Expression_Data_1_markers_c0_LPS_Vs_Control_related_to_Figure_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE148657_3_v_1_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Andarine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0509391
A549_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0569239
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_IOX2_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0547221
STAT3	ENCODE Transcription Factor Targets	1.0	null
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8312
Colon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.082
CTCF_cardiac fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE233679_12_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE228106_3_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
stachydrine-4469	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MOLM13	DepMap CRISPR Gene Dependency	1.0	2.55182
A549_Trichostatin A_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0377664
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Obatoclax Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0505862
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.80961
GSE246660_1_v_0_lmo3_human	RummaGEO Gene Perturbation Signatures	1.0	null
VAL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.08985
CRCGN017_MCF10A.TP53.M_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55593
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20419
A549_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0561484
GSE229973_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.89375
H3K79me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
neuroblast	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_2-Methoxyestradiol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0226316
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0232
A549_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.030642
GTEX-R55D-1226-SM-48FE9	GTEx Tissue Sample Gene Expression Profiles	1.0	2.14567
stomach	HPA Tissue Gene Expression Profiles	-1.0	-1.24208
A549_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0566688
A549_Navitoclax_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189728
A549_MLN8054_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0239165
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN013_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.0935
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GlobusPallidus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.923592
A549_BMS-911543_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.013578
hsa-miR-578	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
A549_Vandetanib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126409
CRCGN015_HEPG2_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.1307
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE206516,GSE206518_0_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Vaginal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
A549_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177706
Teratocarcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-WK11-2426-SM-3NMAA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967848
POLR2A_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRO-0226-SM-3LK6F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07417
A549_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0389686
MED20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99742
GTEX-RWS6-0926-SM-47JXE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.995496
hsa-miR-524-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.436802
GSE146982_7_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Resminostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0388193
MHH-ES-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.52126
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233679_6_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0655204
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Azacitidine_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0285609
GSE175787_4_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U3ZM-0008-SM-4DXTQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.896701
CRCGN012_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.99858
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.920178
hsa-miR-519c-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
SCABER	CCLE Cell Line Gene CNV Profiles	-1.0	-2.10875
A549_Carmofur_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172229
A549_Lenalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0747794
CRCGN009_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34324
17724462-TableS1	GeneSigDB Published Gene Signatures	1.0	null
NCI-H1793	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
A549_MC1568_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0308857
GSE217452_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PSDG-1426-SM-48TD1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19061
BPH-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_2-Methoxyestradiol_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0270589
A549_Iniparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0940402
GTEX-V1D1-1726-SM-4JBHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.860814
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RNOR-1326-SM-48FDE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19401
0225151-0000-6426	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FARAGE	DepMap CRISPR Gene Dependency	1.0	2.67015
PMC9170821-JCMM-26-3183-s001.xlsx-Neu_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TSE9-0226-SM-3DB84	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97243
CRCGN013_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.03704
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.919414
placenta_6b	HPA Tissue Sample Gene Expression Profiles	1.0	0.979346
A549_GSK J1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0607457
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11286
GSE48812_0_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RCC-JF	COSMIC Cell Line Gene Mutation Profiles	1.0	null
alpha-estradiol-1210	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3108
A549_GSK-LSD1 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0607131
PHF20L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01921
PMC4595011-pgen.1005555.s003.xlsx-MITF_DOWN-regulated-Ensembl_gene_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
astroglia	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-P78B-0008-SM-48TE1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25425
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.923364
CRCGN015_HEPG2_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.38054
hsa-miR-20a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
interleukin-18 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.754
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5185
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.6292
YAPC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.846615
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_SRT1720 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164903
EZH2	ENCODE Transcription Factor Targets	1.0	null
GSE221327_8_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XV7Q-2626-SM-4BRVA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91491
A549_Filgotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0643126
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.847651
A549_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0520485
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93169
A549_SRT3025 HCl_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0366403
A549_Alisertib_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0287997
A549_Alvespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0798804
CRCGN015_MCF10A_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.82328
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN009_HEPG2_24H:N19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43736
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00662
tetramisole-4587	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE240344_1_v_0_uxs1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146982_3_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PYGB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84002
A549_Andarine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0476337
A549_G007-LK_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0384237
A549_MLN8054_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0600204
CEBPB_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Andarine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0613709
TMBIM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82525
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.985877
GSE242290_1_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58514
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H661	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
A549_Dacinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0579084
metamizole sodium-4310	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CD8+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.892201
GSE112714_2_v_0_ctnnb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Celecoxib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0740399
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37694
CRCGN013_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.72868
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_PFI-1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0821867
CRCGN017_MCF10A.TP53.M_24H:O20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29922
GTEX-XV7Q-2326-SM-4BRVZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10869
GTEX-U4B1-0926-SM-4DXUV	GTEx Tissue Sample Gene Expression Profiles	1.0	4.15206
A549_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0290844
GTEX-QDT8-0626-SM-48TYW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10957
hsa-miR-1245b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
OCUM-1	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
CRCGN016_MCF10A.WT.HP_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.6017
pentoxifylline-2127	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_ENMD-2076_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.059292
BRIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75604
GTEX-XUZC-0326-SM-4BOO8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42
GTEX-XQ8I-0826-SM-4BOOE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933468
female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_Panobinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0340635
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.1847
A549_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0284315
hsa-miR-760	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
CRCGN017_MCF10A.WT.HP_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0625
CHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.66891
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
KNS42	DepMap CRISPR Gene Dependency	1.0	2.03572
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-607	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
GTEX-OXRN-0226-SM-2I5EJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856316
CRCGN008_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7362
GSE213588_10_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Busulfan_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0459431
hsa-miR-4633-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GTEX-QEL4-1526-SM-447AB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23794
Perturb_471_OE_HEPACAM2_SRP257754	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.0716
RAD21_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUFY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24472
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
wm115	HPA Cell Line Gene Expression Profiles	1.0	0.962061
GSE226770_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
AN3-CA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Nerve sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.141
A549_Aurora A Inhibitor I_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0555174
A549_Iniparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0302666
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35132
A549_Pracinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0682629
A549_Ofloxacin_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0511507
CRCGN013_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.54075
TC-YIK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-3653	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
A549_Mocetinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.048644
A549_M344_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0399569
GSE236502_2_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYADM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92288
RPS4X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60627
hsa-miR-449c	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
hsa-miR-148b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
CTCF	ENCODE Transcription Factor Targets	1.0	null
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04016
A549_UNC1999_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0435198
GTEX-XUYS-0226-SM-47JX1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836732
CRCGN015_MCF10A_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.8531
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42039
A549_BMS-536924_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0617588
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04553
GSE197555_0_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Ramelteon_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0345134
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
hsa-miR-301b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
PMC12640707-NIHMS2124006-supplement-Supplemental_tables.xlsx-Supplemental_Table_S4-Supplemental_Table_S4_Genes_commonly_upregulated_in_both_clones_of_ZFX-depleted_HEK293T_cells_in_Ni_et_al_2020_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
Tongue	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.845205
Bonemarrow	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.37322
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
LY-294002-1216	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
C2BBE1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.75277
GTEX-XV7Q-0008-SM-4BRWL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839345
E2F1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE221327_5_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
A549_AR-42_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0408453
MDA-MB-231	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_EED226_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0567182
SF539	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.20762
A549_Iniparib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0384163
A549_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0257759
OSC-19	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
GTEX-T2IS-0926-SM-4DM5B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86815
A549_Azacitidine_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.00918408
A549_Decitabine_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199739
PMC9899501-NIHMS1869252-supplement-Table_S4.xlsx-REACTOME_CUTOFF_2_5_TOTAL-HAND1_HAND1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843665
GSE145639_1_v_2_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-449	GDSC Cell Line Gene Expression Profiles	1.0	2.98539
hsa-miR-2114	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5045
ES7	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0457564
A549_JQ1_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210449
streptomycin-5837	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
GTEX-P4QT-0008-SM-48TDZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
TC-71	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2823
SF268	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
SARS-CoV_48Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.87083
A549_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0577985
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14062
chr9_42126772_G_A_b38	GTEx eQTL 2025	1.0	1.87477
hsa-miR-509-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
hsa-miR-130a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ES-I3 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.74234
A549_Sorafenib Tosylate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133569
A549_Glesatinib(MGCD265)_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0218489
A549_Flavopiridol HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0227592
A549_MC1568_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0349872
CPSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20814
A549_Aminoglutethimide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.073467
Vasculature-artery endothelial cell	Tabula Sapiens Gene-Cell Associations	1.0	0.704561
GTEX-SSA3-0002-SM-3P61R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07678
Perturb_7755_KD_NOLC1_SRP316009	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.3135
MRM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11943
GTEX-QDT8-0011-R7A-SM-32PKF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00764
A549_GSK-LSD1 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0376959
no-10	GDSC Cell Line Gene Expression Profiles	-1.0	-1.45806
GTEX-OXRP-0226-SM-3NB14	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60249
A549_Decitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0492565
HOXD10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4545
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Entacapone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166898
GTEX-SUCS-1826-SM-32PM1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856359
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
GSE155162,GSE155169_1_v_3_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE181461_1_v_4_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
harmol-7320	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_Pracinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0416971
CRCGN015_MCF10A_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.72855
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN009_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18561
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
496100456_TCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.01054
CRCGN012_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.07439
A549_Lomustine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0457597
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
GTEX-RWS6-1026-SM-47JXD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14131
496100503_HIP_probable Alzheimer's disease_no TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.24503
A549_Cediranib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0336599
hsa-miR-511	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.885287
RERF-LC-SQ1	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
NB10	GDSC Cell Line Gene Expression Profiles	-1.0	-1.65456
GTEX-QVUS-0008-SM-447AY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
GPAT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43614
A549_PD173074_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0522775
HNF4A	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_INO-1001_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0351316
A549_Alisertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0261656
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE143692_0_v_1_trim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_AMG-900_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0263125
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_2_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Navitoclax_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199726
A549_ZM 447439_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0392002
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
phenacetin-3992	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.972675
GTEX-P44H-0008-SM-48TDW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20216
LB2241-RCC	COSMIC Cell Line Gene CNV Profiles	1.0	2.15892
GSE221327_6_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
BICR16	CCLE Cell Line Gene CNV Profiles	1.0	1.65563
A549_Capecitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0365154
GSE221327_4_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
cefmetazole-5868	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BCB000038-7520	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN014_HEPG2_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25252
A549_Roxadustat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0468627
GSE229973_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.94365
PMC3721393-bjc2013326x2.xls-Breast_Cancer_SOX10_Gene_Sig-Unnamed_1_SOX10	Rummagene Transcription Factor Associations 2026	1.0	null
TBCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15795
CTCF_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Ki8751_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0372689
A549_Nilotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161803
LSG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25088
CRCGN015_HEPG2_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.93997
A549_Nintedanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0778045
NCI-SNU-5	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
LPCAT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54913
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211128_9_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
TMEM187	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41047
A549_Azacitidine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0249017
CTCF_fibroblast of the aortic adventitia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08162
GM2493	BioGPS Cell Line Gene Expression Profiles	1.0	2.41625
GSE202434,GSE202438_7_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NB1	DepMap CRISPR Gene Dependency	1.0	2.26398
GSE205163,GSE205164_2_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
Megalocornea	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
teratocarcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0373422
TEX30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35827
GSE133087_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_WHI-P154_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0673705
GTEX-SN8G-0008-SM-4DM4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
A549_Mocetinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0721186
CRB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57588
CRCGN015_MCF10A_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.1303
CRCGN012_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1562
A549_Ivosidenib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0914804
CRCGN015_HEPG2_48H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66164
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QV31-1326-SM-2S1QE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.898851
LB1047RCC	DepMap CRISPR Gene Dependency	1.0	6.32325
CRCGN013_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.04755
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
A549_SRT3025 HCl_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0273346
GTEX-R55C-1626-SM-48FEG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878869
hsa-miR-519b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
A549_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.035631
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4662b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
chloropyrazine-5750	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
16474848-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.19531
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Pelitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.072622
GSE134029_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
COR-L105	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
GTEX-RVPU-2326-SM-2TF6R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08458
A549_TG101209_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0403349
GSE221327_10_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XMK1-0008-SM-4GICF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.895399
A549_Momelotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0373831
GSE221327_10_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Givinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0447565
KOSC2	DepMap CRISPR Gene Dependency	1.0	3.76078
GSE211128_9_v_8_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12354803-42003_2025_8643_MOESM2_ESM.xlsx-2w_TP63_positive-Gene_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3923
PMC8507136-12935_2021_2224_MOESM5_ESM.xlsx-CREB1_upregulated_RRHO_list-RRHO_concordant_degree_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Entacapone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.07877
NCIH510	DepMap CRISPR Gene Dependency	1.0	3.03139
A549_XAV-939_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0357005
PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Significant_DE_genes_in_AKT1_vs_KLF4_meningiomas_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN012_HEPG2_24H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.06969
IL21_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
H3K4me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A549	CCLE Cell Line Gene CNV Profiles	1.0	1.52325
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PWN1-0226-SM-2S1OZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18165
A549_Celecoxib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0573246
CRCGN015_MCF10A_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.04985
GTEX-QV31-0008-SM-447AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02598
A549_WHI-P154_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0435687
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.885287
A549_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0394919
HPAC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Tacedinaline_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0262435
GSE139016_3_v_2_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE186471_1_v_2_carnosol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CCR10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22364
GTEX-PSDG-0008-SM-48TE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.014
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PLZ6-1326-SM-3NB24	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10395
A549_Aurora A Inhibitor I_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0344005
CRCGN009_HEPG2_24H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.09044
A549_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0429059
GSE206729_4_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SNU1196	DepMap CRISPR Gene Dependency	1.0	2.02658
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CYB561D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00474
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.985877
GTEX-R55F-1226-SM-2TF59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
GTEX-WFJO-0426-SM-4LVM7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2795
CAMTA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26631
A549_Barasertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161743
GSE229973_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XQ3S-1026-SM-4BOPJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09218
GSE146982_7_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.905289
A549_AZ 960_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0406885
GSE193258,GSE193259_2_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213410_2_v_3_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Pracinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0362177
A549_Luminespib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.036147
hel	HPA Cell Line Gene Expression Profiles	-1.0	-1.05471
A549_Tucidinostat_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0667437
hsa-miR-431	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
A549_Decitabine_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0232759
decamethonium bromide-4094	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
16-phenyltetranorprostaglandin E2-7546	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Tozasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0554096
PTTG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25648
CRCGN011_HEPG2_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76055
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE85565_1_v_0_tcf21_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QVJO-0011-R6A-SM-2S1QN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.973198
hsa-miR-454	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUW1-1826-SM-4BOQD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884571
GTEX-R55D-0826-SM-48FEA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857344
lysosome	LOCATE Predicted Protein Localization Annotations	1.0	null
LCLC103H	DepMap CRISPR Gene Dependency	1.0	3.44872
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05234
MAPK8IP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51938
A549_Trametinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0472208
GSE200839,GSE233826_3_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_KW-2449_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.02934
CRCGN014_HEPG2_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33268
G401	CCLE Cell Line Gene CNV Profiles	1.0	1.7753
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.49427
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE96649_1_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_WP1066_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.038762
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
0173570-0000-3693	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-4456	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
A549_PCI-34051_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222008
CRCGN012_HEPG2_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.98442
SP1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
estradiol_mus musculus_gpl4134_gse23072	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XPVG-1326-SM-4B65P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08409
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Selisistat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158869
hsa-miR-4325	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
A549_Resveratrol_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148555
CRCGN010_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17125
GTEX-QDVJ-0005-SM-2TC5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970184
GTEX-WRHU-0726-SM-3MJFL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.899117
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Adipose - Subcutaneous	GTEx Tissue Gene Expression Profiles 2023	1.0	2.33428
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN013_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60274
COLO824	DepMap CRISPR Gene Dependency	1.0	5.46322
A549_Ellagic acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0371179
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35132
Perturb_6892_KO_KDM3A_SRP128505	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.5608
GSE70935_1_v_0_cyfip1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Motesanib Diphosphate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0259697
Perturb_1341_KD_RAC3_SRP368300	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.60974
A549_Droxinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0734877
Bimatoprost_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0203131
A549_Triamcinolone Acetonide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0527825
GTEX-UPK5-1326-SM-4IHLE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44583
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-2278	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
A549_Hesperadin_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0644977
GSE221327_8_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WFON-1026-SM-4LVMD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16561
GSE189789_0_v_1_oridonin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SNOS-0726-SM-4DM5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41939
A549_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191495
A549_Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0485138
GTEX-UPK5-2326-SM-3P5Z8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98797
GSE148263_6_v_0_trim3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11884
TGBC1TKB	DepMap CRISPR Gene Dependency	1.0	3.68784
CTCF_LNCaP clone FGC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125219,GSE125221_5_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE225901_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Regorafenib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0622625
A549_Barasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0396694
GSE211128_4_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Ki16425_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0506877
A549_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0455336
Dermatome	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.511
GTEX-OHPM-0008-SM-4E3IP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
Perturb_1349_KD_UBC9_SRP153825	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-17.8182
GTEX-SSA3-0005-SM-32QOT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06833
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Ellagic acid_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0509034
CRCGN014_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.21099
496100358_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.16395
hsa-miR-4762-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
A549_SB431542_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168961
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05234
TYK-NU	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
A549_Divalproex Sodium_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0421194
A549_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0479128
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
GSE147876,GSE147877_4_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
methotrexate-6318	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN014_HEPG2_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.85434
NMC-G1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-S7SE-0008-SM-33HB1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843656
GTEX-S3XE-0008-SM-3NM8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.884372
GTEX-RU72-0008-SM-46MV8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25128
KYSE-450	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
A549_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0538747
A549_Roscovitine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0268932
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20518
1321N1	CCLE Cell Line Gene CNV Profiles	1.0	1.44484
SW1783	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE146982_3_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_fibroblast of pulmonary artery_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
hsa-miR-590-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
A549_TG101209_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0518054
A549_AZD1480_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0313407
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
CRCGN011_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7504
GSE99687_0_v_1_smad5_human	RummaGEO Gene Perturbation Signatures	1.0	null
PPP1CC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38576
GTEX-XBED-0926-SM-48TCE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21183
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN008_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4896
GSE208634_1_v_2_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2551
496100579_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.08702
GSE175787_4_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Tongue-vein endothelial cell	Tabula Sapiens Gene-Cell Associations	1.0	0.166041
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QXCU-0008-SM-48FCH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
CRCGN012_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.52391
GTEX-X638-0226-SM-47JZ9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935783
A549_PHA-680632_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0285362
GTEX-QESD-0008-SM-447B2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
CRCGN017_MCF10A.WT.HP_24H:K22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4025
A549_SGI-1776 free base_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0474486
CDC26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74266
A549_PF-3845_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0660257
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19698
hmc1	HPA Cell Line Gene Expression Profiles	-1.0	-1.05471
769-P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.83989
CRCGN012_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.32882
CRCGN012_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.86824
GSE131649_4_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tanespimycin-4449	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE205163,GSE205164_1_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_ENMD-2076 L-Tartaric acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140875
A549_PCI-34051_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0371776
A549_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0490795
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17024
GTEX-XQ8I-1826-SM-4BOOJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.862267
A549_Panobinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.053916
CRCGN015_MCF10A_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.6114
PMC9068765-41467_2022_29960_MOESM14_ESM.xlsx-TP53-Unnamed_2_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R45C-0008-SM-48FF2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.99544
spinal cord	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO320	CCLE Cell Line Gene CNV Profiles	1.0	1.7314
PGA1	DepMap CRISPR Gene Dependency	1.0	3.37871
hsa-miR-3129-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GSE221327_5_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
SNU1076	CCLE Cell Line Gene CNV Profiles	1.0	1.75887
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4775	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
A549_Divalproex Sodium_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0524147
A549_Zileuton_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0714147
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
chr9_42125602_A_G_b38	GTEx eQTL 2025	1.0	1.50405
PMC8600817-12951_2021_1120_MOESM2_ESM.xlsx-Table_S4-Table_S4_Pan_PPAR-iMSC-EV-induced_differentially_expressed_genes_in_fatty_acid-treated_HepG2_cells_PPARA	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-3190	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
UMC-11	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
DU 145	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36772
hsa-miR-3662	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
CRCGN017_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.9886
GTEX-QCQG-1826-SM-2S1P2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19577
A549_SL-327_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0556641
A549_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0526638
esophagus	HPA Tissue Gene Expression Profiles	1.0	1.31238
CRCGN014_HEPG2_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11444
A549_FLLL32_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0453149
GTEX-XK95-0008-SM-4AT5G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
PSS131R	DepMap CRISPR Gene Dependency	1.0	2.52816
GSE185519_1_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865183
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_CEP-33779_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0389979
A549_Meprednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0495871
A549_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186147
A549_S-Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0864453
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN010_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1305
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0367438
HCC1806	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.03742
GSE142210_9_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
A549_Quisinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0385869
GSE211128_7_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Temsirolimus_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.03846
GTEX-S4Z8-0726-SM-4GICB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7655
GSE233679_14_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0613811
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-17	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
SUIT-2	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Supplementary_Table_2E_Contrast_ATF4-def_Tg_8h_vs_HCT116_Tg_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XBED-0008-SM-47JWO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
CRCGN015_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.80313
GSE211357_1_v_3_atg7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191904
EJM	DepMap CRISPR Gene Dependency	1.0	2.82629
PRDM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5805
A549_TAK-901_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216236
karpas707	HPA Cell Line Gene Expression Profiles	-1.0	-1.05471
CRCGN012_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26012
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RNF103	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11307
HS571T	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55502
RVH-421	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-S33H-0008-SM-4AD6C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18257
GSE184087_2_v_1_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NKX2-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3308
econazole-7305	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE210101,GSE210114_8_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WFG7-1026-SM-4LMK8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40471
A549_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0481218
A549_A-366_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0597439
A549_Enzastaurin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0283236
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
A101D	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
A549_JNJ-7706621_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0339604
A549_AG-490_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0289841
GTEX-VJWN-0426-SM-3GIJI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1644
A549_Disulfiram_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0581796
A549_BRD4770_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152791
A549_Cerdulatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.03825
COV434	DepMap CRISPR Gene Dependency	1.0	2.35006
GTEX-W5X1-1426-SM-3GIKH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33188
GSE96777,GSE96778_1_v_0_zbtb4_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Tubastatin A HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0673574
WSU-DLCL2	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
CRCGN013_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2721
A549_Ivosidenib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0702612
A549_Raltitrexed_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0339336
A549_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0630799
A549_AICAR_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0514535
A549_PD173074_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206275
GTEX-X585-0008-SM-46MU4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15887
GTEX-WFON-2226-SM-3TW8W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827127
TT2609C02	CCLE Cell Line Gene CNV Profiles	1.0	1.4245
LS-411N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Quisinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0440645
GTEX-Q2AH-1026-SM-48TZI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2999
CRCGN015_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01879
A549_Raltitrexed_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0261617
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05345
GSE233679_14_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Celecoxib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.058994
GSE242083,GSE242098_3_v_0_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863674
hsa-miR-129-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE141143_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PANC-08-13	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
A549_Ki8751_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0351892
GTEX-VUSH-0008-SM-47JWK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.99349
A549_PHA-680632_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0322966
GTEX-WRHU-1326-SM-4E3K7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0548
GSE235066_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_MK-5108_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0544195
hsa-miR-4760-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
CRCGN012_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.50388
VRTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22583
GTEX-RU1J-0426-SM-46MUK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28829
A549_MLN8054_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0344892
LN18	BioGPS Cell Line Gene Expression Profiles	1.0	1.53844
GTEX-U412-0326-SM-3DB9L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828203
hsa-miR-507	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
blood	GTEx Tissue Gene Expression Profiles	-1.0	-1.55306
GSE210682_2_v_1_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.97422
GSE229671,GSE229673_0_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-O5YU-0008-SM-4E3I7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
MFM-223	GDSC Cell Line Gene Expression Profiles	-1.0	-1.57289
A549_2-Methoxyestradiol_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0494153
PHA-00745360-4559	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Obatoclax Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0427102
LMCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19839
LAN-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-U4B1-1726-SM-3DB9F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06661
hsa-miR-4741	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
A549_JNJ-7706621_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0511021
hsa-miR-4426	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
A-CA-04-2009(H1N1)_6Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.4239
A549_Ofloxacin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0422753
CRCGN017_MCF10A.WT.HP_24H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4062
GSE191015_0_v_2_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0422626
LNZTA3WT4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0387762
A549_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0308859
A549_Prednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.027128
A549_TG101209_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0860661
PMC7862469-13238_2020_779_MOESM4_ESM.xlsx-FOXO3-GE_VS_WT-Symbol_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
METTL24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04184
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN012_HEPG2_24H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30683
A549_AG-490_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0506326
A549_SRT1720 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.046761
hsa-miR-3609	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.50083
CRCGN008_HEPG2_24H:G24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.1916
A549_Fasudil_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0660116
acacetin-3767	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC-56	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.055199
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.2698
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.050106
RPS19BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36469
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BLTP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40252
HCC515	DepMap CRISPR Gene Dependency	1.0	2.18771
Astrocytoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NR3C1_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7922
A549_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0455878
GSE213588_9_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WFJO-0726-SM-4LVM8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41225
EMC-BAC-1	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
azathioprine-4667	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE202434,GSE202438_3_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Mesna_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0352291
CTCF_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRDM12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22822
Appendix adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
CDK17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24637
GTEX-WFON-0926-SM-4LVMK	GTEx Tissue Sample Gene Expression Profiles	1.0	2.59998
GSE202434,GSE202438_3_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE192362_1_v_0_erastin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10149505-41392_2023_1393_MOESM2_ESM.xlsx-CPCMR-Hugo_Symbol_MEIS2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
TCF3	ENCODE Transcription Factor Targets	1.0	null
GTEX-XQ3S-0526-SM-4BOQA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874652
SIVA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02461
PTK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01346
A549_GSK-LSD1 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.049658
GTEX-S7SE-0826-SM-4AT4D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11573
HCC1806	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-V1D1-2426-SM-3GAER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.961448
epiandrosterone-4626	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_Lenalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0413338
ZR-75-30	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MORCPR	DepMap CRISPR Gene Dependency	1.0	3.13162
hsa-miR-505	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
A549_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0286391
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
fluphenazine-1237	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
fat_a.V1	HPA Tissue Sample Gene Expression Profiles	1.0	1.39878
GSE175787_4_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TKQ1-0226-SM-33HB5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6788
CRCGN012_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19947
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27073
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_1_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
A549_PD173074_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.035017
CRCGN014_HEPG2_3H:H18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12784
stomach_3a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.919687
Dedifferentiated liposarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
RPL13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80865
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-X4EO-2726-SM-4E3HS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844251
ZNF283	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72829
A549_Baricitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0564724
GSE193402_0_v_3_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0397025
CRCGN015_MCF10A_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28862
EW1	DepMap CRISPR Gene Dependency	1.0	2.39804
A549_Ofloxacin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0322572
NR3C1	ENCODE Transcription Factor Targets	1.0	null
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Bosutinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0458412
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Supplementary_Table_2D_Contrast_ATF4-def_Tg_2h_vs_HCT116Tg_2h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE164874_5_v_3_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.26792
chr9_41995588_G_A_b38	GTEx eQTL 2025	1.0	1.17129
PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-216a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Almonertinib (hydrochloride)_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0122619
GTEX-OOBK-0726-SM-3LK5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31245
A549_Nintedanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0395049
OSR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.4338
A549_Quercetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0411627
CRCGN009_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.62641
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825922
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
A549_Resveratrol_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0261711
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZM-0626-SM-4DXTV	GTEx Tissue Sample Gene Expression Profiles	1.0	2.21421
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-PWN1-1726-SM-2S1O9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.970603
THBS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80637
TAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45604
GSE146982_7_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE233679_14_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226249_2_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Veliparib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0660338
GSE236502_1_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Enzastaurin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0611249
GSE155031_5_v_1_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OXRP-0126-SM-3NB32	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841923
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XV7Q-1026-SM-4BRVR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45702
GSE70935_3_v_5_cyfip1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Epididymis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.082
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
AFDN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48466
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30421
GTEX-RM2N-0008-SM-48FF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72732
GTEX-WFON-0526-SM-4LVLY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955072
hsa-miR-4768-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
NCI-H647	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
LOX-IMVI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.922342
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WHWD-0826-SM-3LK6R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836636
GTEX-Q2AG-0926-SM-48U1Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.899505
FOSL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NFK9-0326-SM-3MJGV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870375
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPVG-1726-SM-4B65W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28026
A549_Tanespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0521406
A549_SRT2104_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0368541
nomifensine-5863	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-N7MS-0008-SM-4E3JI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965528
A549_Carmofur_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0617232
A549_PD98059_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0391811
A549_NVP-BSK805 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0540906
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.95965
7455_RPL27_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.21039
A549_2-Methoxyestradiol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147359
interleukin-12 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.555
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0923
A427	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.7778
A549_BMS-911543_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0394522
CRCGN014_HEPG2_3H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59632
A549_Hesperadin_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0754888
beclometasone-4580	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE135439_0_v_1_pax5_human	RummaGEO Gene Perturbation Signatures	1.0	null
wortmannin-4467	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952274
isopropamide iodide-2720	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Deprivation amblyopia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.296
A549_Divalproex Sodium_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0456206
PMC7617064-EMS151900-supplement-Figure_7_Source_Data.xlsx-HLC_D9_DEG-Logfold_change_threshold_1_0_1_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19489
GSE221327_8_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE221327_10_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-3686	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
hsa-miR-148a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GTEX-WFG8-1726-SM-4LVM6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878853
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-C_ATF4-def_vs_HCT116_DMSO8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152699,GSE152723_3_v_2_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE236437_2_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.07593
GSE221327_5_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
RTN4IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15191
finasteride-3744	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RUSQ-2026-SM-4GIAK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24539
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33167