association	dataset	threshold value	standardized value
PMC7405480__F2	PFOCR Pathway Figure Associations 2024	1.0	null
JHOS2_OVARY	CCLE Cell Line Proteomics	1.0	4.60864
PMC6532413__F2	PFOCR Pathway Figure Associations 2023	1.0	null
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
K562_WP1066_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0267852
K562_Trametinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0117246
A549_SRT2104_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145772
K562_Gandotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0217672
GSE254770_0_v_1_sin3b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Alendronate sodium trihydrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0256882
PMC5516996__F3	PFOCR Pathway Figure Associations 2024	1.0	null
MCF7_Ki16425_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0232195
A549_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019889
MCF7_Resminostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196004
MORCPR	DepMap CRISPR Gene Dependency	1.0	2.71271
VP229	DepMap CRISPR Gene Dependency	1.0	2.15085
ubiquitin protein ligase activity	GO Molecular Function Annotations 2023	1.0	null
K562_Amisulpride_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0365502
K562_Decitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146427
A549_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0102298
PMC7889978__F2	PFOCR Pathway Figure Associations 2023	1.0	null
PMC4844344__F12	PFOCR Pathway Figure Associations 2023	1.0	null
K562_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0254776
A549_Pracinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190847
GSE154081_3_v_0_sildenafil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Triamcinolone Acetonide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00888168
MOLM14	DepMap CRISPR Gene Dependency	1.0	2.47193
496100597_HIP_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.60544
A549_Raltitrexed_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179474
PMC4663793__F3	PFOCR Pathway Figure Associations 2023	1.0	null
K562_XAV-939_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173409
GSE153064,GSE153065_1_v_2_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pramipexole	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.41
K562_Raltitrexed_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0425257
K562_Entinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152382
LRIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38026
MCF7_Tozasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154317
GSE253041_1_v_0_ramp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Barasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0217821
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal heart development	MGI Mouse Phenotype Associations 2023	1.0	null
MCF7_Tofacitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172479
Congenital fibrosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
A549_Aurora A Inhibitor I_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152456
MCF7_UNC1999_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129674
MCF7_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209664
MCF7_Pirarubicin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139695
MCF7_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0343661
K562_ABT-737_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161819
A549_CUDC-907_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0233504
NDUFA10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08826
K562_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0340567
BAZ1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97852
A549_Busulfan_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0319941
LOXIMVI_SKIN	CCLE Cell Line Proteomics	1.0	7.21938
K562_PCI-34051_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.026759
A549_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.024407
A549_JNJ-7706621_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0279127
K562_BRD4770_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0419311
K562_Valproic acid sodium salt_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015496
PMC5524348-pone.0181667.s005.xlsx-Inflammation-MINT_SPEN	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Tofacitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0286324
K562_Lapatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0371809
GSE252857_1_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Navitoclax_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0290011
FUBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16955
A549_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176416
GSE137954_4_v_2_smyd3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Panobinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0090776
MCF7_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156425
A549_MC1568_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194872
MCF7_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223066
GSE130383_1_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ASPC1	DepMap CRISPR Gene Dependency	1.0	2.54359
MCF7_Quisinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0102975
C5orf22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02385
MCF7_S3I-201_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141427
K562_Aminoglutethimide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216426
PMC5537703-MOL2-11-965-s002.docx-1-NFX1_NFX1	Rummagene Transcription Factor Associations 2026	1.0	null
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.138
K562_Triamcinolone Acetonide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200701
MCF7_A-366_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134844
PMC3440207__F8	PFOCR Pathway Figure Associations 2023	1.0	null
MCF7_Fluorouracil_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212349
MCF7_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0300705
MDAMB435S	DepMap CRISPR Gene Dependency	1.0	2.73528
MCF7_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130466
A549_Dasatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0266648
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH1993	DepMap CRISPR Gene Dependency	1.0	2.10525
A549_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147208
HUH7	DepMap CRISPR Gene Dependency	1.0	2.48256
A549_Tacedinaline_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0242831
SNU685	DepMap CRISPR Gene Dependency	1.0	2.40369
GSE145323,GSE145324_9_v_2_rfx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_AT9283_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0114192
PMC5127598__F5	PFOCR Pathway Figure Associations 2023	1.0	null
K562_Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212241
MCF7_ABT-737_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168322
K562_Fedratinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0327472
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.451
MCF7_CYC116_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127994
GSE148066,GSE157787_2_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Navitoclax_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116927
K562_Andarine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0372079
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.658
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.41
K562_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019163
MCF7_Mocetinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0115948
MCF7_Abexinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184161
Appendix disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.044
MCF7_Linifanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143863
A549_PFI-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215476
A549_PCI-34051_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.023779
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.429
PMC5577301-in-17-237-s001.xls-AR_upregulated_DEGs-Heart_GSE9377_GENE_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GAMG	DepMap CRISPR Gene Dependency	1.0	2.36726
A549_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144294
PMC6719526__F4	PFOCR Pathway Figure Associations 2024	1.0	null
ZNF726	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21835
K562_Givinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196736
MCF7_Entacapone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197351
GSE148066,GSE157787_8_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Selisistat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157762
COLO205	DepMap CRISPR Gene Dependency	1.0	2.66517
A549_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0294589
MCF7_AZD1480_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0246841
K562_YM155_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147968
METTL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24229
PMC7727076__F6	PFOCR Pathway Figure Associations 2024	1.0	null
A549_PHA-680632_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187705
PMC7989008__F5	PFOCR Pathway Figure Associations 2023	1.0	null
A549_SRT3025 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163466
GSE127790_4_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TXNDC16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00729
GSE71529,GSE71558_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Belinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168556
A549_UNC0379_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198926
MCF7_Toremifene Citrate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214931
A549_Thalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014695
MCF7_INO-1001_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214466
K562_Obatoclax Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0374537
K562_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.035128
PMC11282827-40659_2024_524_MOESM5_ESM.xlsx-SOX14-sequence_name_SOX14	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Tranylcypromine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201692
496100632_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.82686
Minor Salivary Gland	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.345
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SMAD3-30307970-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
A549_Glesatinib(MGCD265)_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160275
OCILY19	DepMap CRISPR Gene Dependency	1.0	2.49191
Schizophrenia 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.035
A549_ZM 447439_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0350259
Endometriosis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.268
MCF7_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0295163
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.572
A549_Filgotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0271877
GSE124410_2_v_5_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
PMC6274615__F1	PFOCR Pathway Figure Associations 2023	1.0	null
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
Appendix carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.35
XPO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81019
K562_Resveratrol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0273045
PMC5515284__F7	PFOCR Pathway Figure Associations 2023	1.0	null
PMC3419980-leu201249x6.xls-RUNX1-DHS-1000bp-Unnamed_0_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
KARPAS1718	DepMap CRISPR Gene Dependency	1.0	2.1777
PMC6861914__F6	PFOCR Pathway Figure Associations 2023	1.0	null
MCF7_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0302654
GSE191174_0_v_1_ccdc92_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0290845
A549_Tazemetostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124469
PMC3500769-srep00875-s3.xls-PAX2-Time_0_PAX2	Rummagene Transcription Factor Associations 2026	1.0	null
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
CALML6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01223
PMC5468232__F12	PFOCR Pathway Figure Associations 2024	1.0	null
EW7	DepMap CRISPR Gene Dependency	1.0	2.3276
K562_CUDC-101_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0555607
496100358_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.29399
PMC2795496__F5	PFOCR Pathway Figure Associations 2023	1.0	null
GSR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0886
GSE157555,GSE157556_3_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.036692
MCF7_UNC0379_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0300837
GTEx Thyroid 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-5.61048
GSE130383_2_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Alendronate sodium trihydrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182266
PMC7430825__F8	PFOCR Pathway Figure Associations 2023	1.0	null
K562_Crizotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148604
A549_Crizotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0278738
MCF7_BRD4770_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169987
A549_SRT1720 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186142
KKU213	DepMap CRISPR Gene Dependency	1.0	2.1924
A549_Sodium Phenylbutyrate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185378
MCF7_PHA-680632_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0290672
A549_Hesperadin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164041
increased B cell derived lymphoma incidence	MGI Mouse Phenotype Associations 2023	1.0	null
OVTOKO	DepMap CRISPR Gene Dependency	1.0	2.30904
A549_GSK-LSD1 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016105
K562_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0262324
A549_Ellagic acid_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0220139
A549_Abexinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00955826
PMC6613612__F7	PFOCR Pathway Figure Associations 2024	1.0	null
MCF7_WHI-P154_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0264019
PMC7262827__F5	PFOCR Pathway Figure Associations 2024	1.0	null
PMC9825391-41467_2022_35592_MOESM4_ESM.xlsx-MAF_Targeted_Seq_mutations-Muation_Annotation_File_MAF_used_in_Figures_1b-e_3a-b_Supplementary_Figures_2d_2f_2g_and_4a_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0416694
PMC2856676__F1	PFOCR Pathway Figure Associations 2023	1.0	null
PMC5039670__F4	PFOCR Pathway Figure Associations 2024	1.0	null
A549_Resminostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173006
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_64_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0321177
MCF7_Streptozotocin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189748
PMC5193459-pone.0168968.s009.xlsx-Dharmacon_OTP_siRNA_Area-Symbol_OTP	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12350161-43587_2025_925_MOESM1_ESM.xlsx-ST12-Unnamed_10_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Resminostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0404406
A549_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151915
K562_JQ1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149018
PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-FLI1_mod_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
CBLN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23126
A549_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0327665
BPGM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03177
K562_Ivosidenib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223472
HT29	DepMap CRISPR Gene Dependency	1.0	2.61451
PMC8025515-12859_2021_4105_MOESM12_ESM.xlsx-PW1-gene_stable_id_PEG3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7708794-mmc2.xlsx-DGE_table_Imm-high_vs_Imm-low-TFT_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
K562_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193812
MCF7_CUDC-907_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184636
SLC66A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92467
A549_Capecitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141758
A549_Bisindolylmaleimide IX_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216262
GSE228181_3_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context1_2-Gene_Name_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
WDCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03905
A549_JQ1_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0303471
A549_SRT3025 HCl_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202987
A549_GSK-LSD1 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.025261
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
MCF7_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0310925
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Basal_KLF5_peaks-Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.094
A549_Carmofur_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00987643
GSE216147_2_v_1_rbm20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Entinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187778
MCF7_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222953
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.411
K562_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0247876
K562_Busulfan_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0310574
K562_SRT2104_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0435598
MCF7_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186019
GSE159937_1_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Enzastaurin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0249555
K562_JQ1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016191
PMC11408861-mmc2.pdf-9-CLOCK_CLOCK	Rummagene Transcription Factor Associations 2026	1.0	null
GSE114992,GSE114993_4_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Mercaptopurine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0413849
MCF7_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155015
GSE77178_1_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_UNC1999_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176813
ESO26	DepMap CRISPR Gene Dependency	1.0	2.32992
K562_Ki8751_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163104
MALME3M	DepMap CRISPR Gene Dependency	1.0	2.61415
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.407
A549_Selisistat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209891
MCF7_Daphnetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206083
GSE131887_1_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE180200,GSE180201_5_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_SGI-1776 free base_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0246186
GSE179031_0_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6717296__F5	PFOCR Pathway Figure Associations 2023	1.0	null
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Nearest_Ensembl_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
K562_PFI-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0415133
GSE126621,GSE126920_1_v_3_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Flavopiridol HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153197
Stabilization of p53	Reactome Pathways 2024	1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.24
A549_Tucidinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0201176
A549_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165416
PMC4965087__F2	PFOCR Pathway Figure Associations 2023	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_60_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
PSMB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74436
NSC19883	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
MCF7_Entinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0302649
VAX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70696
MCF7_Entinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.025178
K562_TG101209_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159437
A549_AZ 960_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161083
PMC5524348-pone.0181667.s005.xlsx-ER_Stress-MINT_SPEN	Rummagene Transcription Factor Associations 2026	1.0	null
K562_MK-5108_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0383087
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
L363	DepMap CRISPR Gene Dependency	1.0	2.56652
A549_Costunolide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0430262
GSE140092_0_v_1_socs3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_TGX-221_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0349243
K562_Fedratinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0490041
K562_Alendronate sodium trihydrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186681
GSE110268_1_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
K562_G007-LK_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0384071
K562_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213611
EKVX	DepMap CRISPR Gene Dependency	1.0	2.17753
MCF7_PD173074_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135443
K562_INO-1001_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196855
A549_AR-42_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165919
A549_Dacinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0116643
GSE81193_0_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Hesperadin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117556
PMC11842253-DataSheet3.pdf-30-FOXJ3_FOXJ3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Fasudil_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0324946
MCF7_WP1066_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149681
GSE205550,GSE205552_2_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.287
MCF7_PD173074_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019668
MCF7_EED226_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150729
A549_MK-0752_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0242274
MCF7_Anacardic Acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149983
GSE65617_2_v_3_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.039082
A549_Anacardic Acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0324782
GTEx Muscle 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-20.9892
A549_KW-2449_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184157
K562_BMS-911543_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0349085
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_14_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Tofacitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152299
GSE213632_3_v_6_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Tofacitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0331093
MCF7_FLLL32_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00945217
K562_SRT3025 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.043259
A549_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194009
496100339_HIP_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.91715
K562_WP1066_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017699
A549_AR-42_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129979
PMC10641274-mmc2.xlsx-FOXK1_Insulin-ENSEMBL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Vandetanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0233516
MCF7_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0218414
A549_EED226_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172459
K562_AR-42_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181274
GSE188870,GSE188871_0_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Costunolide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0296719
MCF7_SGI-1776 free base_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156711
K562_Quercetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0290165
K562_Ki16425_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0245306
K562_Tranylcypromine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162171
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.344
K562_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0520297
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Resveratrol_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131439
PMC5686903__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE228181_4_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_BMS-265246_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0106422
RBE	DepMap CRISPR Gene Dependency	1.0	2.53701
GSE145445,GSE145454_0_v_1_cop1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_EED226_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0275514
MCF7_SNS-314 Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151486
A549_Roxadustat_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207747
ENY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11914
Neddylation	Reactome Pathways 2024	1.0	null
K562_Maraviroc_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0320747
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_Obatoclax Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199771
PMC3669416-pone.0064838.s001.xls-mHTT-HOXD8_HOXD8	Rummagene Transcription Factor Associations 2026	1.0	null
K562_ABT-737_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0229436
OE21	DepMap CRISPR Gene Dependency	1.0	2.7118
MCF7_Resveratrol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192926
K562_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0289286
GSE140200_1_v_3_trim59_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158481
RAB29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30339
LRRC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13174
K562_A-366_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169989
MCF7_BMS-536924_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0363792
K562_Rucaparib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0227807
A549_TGX-221_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.028694
A549_SRT3025 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0299712
SNU449	DepMap CRISPR Gene Dependency	1.0	2.30165
PMC9339612__F1	PFOCR Pathway Figure Associations 2024	1.0	null
PMC7989008__F5	PFOCR Pathway Figure Associations 2024	1.0	null
Reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.268
GSE125782_0_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11236317-aging-16-205930-s001.pdf-1-TBXT_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
A549_PD173074_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0273992
A549_Fasudil_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189604
A549_SRT1720 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0326506
MFAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22975
MCF7_Tazemetostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140752
IKBKB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37216
A549_Hesperadin_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176638
NEUROG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05539
A549_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170509
PMC7012898__F1	PFOCR Pathway Figure Associations 2024	1.0	null
K562_AC480_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197485
GSE211226_1_v_0_sirpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10181312__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0398723
K562_SNS-314 Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.032556
PMC11046918-12967_2024_5211_MOESM4_ESM.xlsx-F_HT1080_FUS-DDIT3_regulated-Table_S2_Regulated_genes_between_scaffold-cultured_and_monolayer-cultured_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Linifanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0645575
Mood disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.955
A549_Bisindolylmaleimide IX_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176972
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.11
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Distal-RefSeq_Name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MELJUSO	DepMap CRISPR Gene Dependency	1.0	2.06072
A549_ZM 447439_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136677
K562_Azacitidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0305205
PMC2263127-pone.0001816.s002.xls-Terms_with_Genes_E2F3_up_Bild-Title_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Tozasertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0266926
A549_Glesatinib(MGCD265)_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196614
MCF7_Lenalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016331
A549_Filgotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.011566
K562_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193504
MCF7_Nilotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187385
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
GSE241036_4_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0285437
A549_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180869
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.396
K562_JNJ-7706621_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0270837
K562_Altretamine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0346454
A549_CUDC-101_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154089
PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
FBXO28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05742
ESR1-26153859-T47D-HUMAN-BREAST-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
Miles-Carpenter syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
PMC10800016-table_s3_20230913_ddad186.xlsx-DUX4-aff_II-Unnamed_1_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120248,GSE120252_1_v_0_macf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE100316_3_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4823852__F8	PFOCR Pathway Figure Associations 2024	1.0	null
K562_EED226_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231864
PMC7751413__F1	PFOCR Pathway Figure Associations 2024	1.0	null
PMC8482521-mmc10.xlsx-Upstreme_Regulators_48_hr_MLR-Unnamed_0_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
JHH5	DepMap CRISPR Gene Dependency	1.0	2.56744
MCF7_Disulfiram_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136786
UTF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78293
KIF2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61135
PMC7053098__F5	PFOCR Pathway Figure Associations 2024	1.0	null
MCF7_Thiotepa_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013446
A549_Belinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.047483
GSE160083,GSE160084_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8507163__F5	PFOCR Pathway Figure Associations 2024	1.0	null
7-Hydroxycoumarine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.34
PMC4823852__F8	PFOCR Pathway Figure Associations 2023	1.0	null
K562_Toremifene Citrate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0371852
LYRM9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63392
A549_PD173074_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0229736
UIMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11984
K562_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147312
A549_Bosutinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0267591
A549_Quisinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0110825
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147613_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145765
Cognitive disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.955
MCF7_AT9283_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182678
MCF7_Baricitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194298
CUX1-19635798-MULTIPLE-CANCER-TYPES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
A549_Pirarubicin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0414091
GSE125025_2_v_3_lyl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Resveratrol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133113
MCF7_CUDC-101_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174511
MCF7_Givinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206651
A549_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156153
K562_2-Methoxyestradiol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0271902
MCF7_S3I-201_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0409753
Cul4A-RING E3 ubiquitin ligase complex	GO Cellular Component Annotations 2023	1.0	null
GSE148066,GSE157787_3_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_BMS-536924_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0362614
regulation of proteasomal ubiquitin-dependent protein catabolic process	GO Biological Process Annotations 2023	1.0	null
GSE80446_2_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context1_2-Nearest_Ensembl_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3575449__F1	PFOCR Pathway Figure Associations 2023	1.0	null
K562_Flavopiridol HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0248377
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_12_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Raltitrexed_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023157
PMC7813639__F2	PFOCR Pathway Figure Associations 2023	1.0	null
MCF7_Capecitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.024152
Chromosomal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
A549_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198209
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.245
ULK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13649
PMC11297993-41419_2024_6957_MOESM2_ESM.xlsx-F-PC_loadings_of_the_242_P53_high_confidence_targets_used_for_the_PCA_in_Figure_5A_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10864182-41588_2023_1596_MOESM4_ESM.xlsx-ST12_Significant_Genes_combine-Supplementary_Table_12_Genes_prioritisation_combining_FUMA_MAGMA_Hi-C_MAGMA_and_TWAS_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
UHRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02014
GSE196671_6_v_1_obox4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_MLN8054_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0221121
NCIH1836	DepMap CRISPR Gene Dependency	1.0	2.18915
A549_Maraviroc_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205265
K562_ENMD-2076_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158639
PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_spleen-Unnamed_1_RAG1	Rummagene Transcription Factor Associations 2026	1.0	null
MAMLD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12687
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_ZR75_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
K562_PCI-34051_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0349133
ubiquitin-like protein ligase activity	GO Molecular Function Annotations 2023	1.0	null
A549_UNC0379_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0285377
MCF7_Triamcinolone Acetonide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00943737
MCF7_AC480_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0102765
PMC6861914__F6	PFOCR Pathway Figure Associations 2024	1.0	null
Cell Cycle	Reactome Pathways 2024	1.0	null
496100453_HIP_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.45026
MCF7_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165045
GSE188870,GSE188871_1_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Curcumin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0396263
A549_Triamcinolone Acetonide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0111903
PMC10709143-41556_2023_1271_MOESM7_ESM.xls-PAX7_Re-injury-Target_name_PAX7	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6656753__F5	PFOCR Pathway Figure Associations 2023	1.0	null
K562_SB431542_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0343665
NALM16	DepMap CRISPR Gene Dependency	1.0	2.67753
A549_Danusertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209884
GSE148066,GSE157787_11_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_y_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6176282__F9	PFOCR Pathway Figure Associations 2023	1.0	null
A549_Aurora A Inhibitor I_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0234681
MCF7_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0103499
MCF7_Glesatinib(MGCD265)_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208244
PMC6313873__F4	PFOCR Pathway Figure Associations 2023	1.0	null
A549_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150015
MCF7_PF-573228_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197923
PMC3500769-srep00875-s3.xls-CEBP-Time_0_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
L-Cysteine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
K562_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0304607
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-E2A_Pre-Pro-B-Cells_ChIP-seq_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
ESO51	DepMap CRISPR Gene Dependency	1.0	2.33589
K562_Obatoclax Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016858
GSE188870,GSE188871_1_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100541_FWM_possible Alzheimer's disease_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.41289
p53-Dependent G1 DNA Damage Response	Reactome Pathways 2024	1.0	null
A549_TG101209_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144631
RNF216	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2109
MCF7_Streptozotocin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0367024
A549_Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136854
KMS27	DepMap CRISPR Gene Dependency	1.0	2.56293
A549_Decitabine_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0237997
MCF7_2-Methoxyestradiol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0283814
PMC3976861__F2	PFOCR Pathway Figure Associations 2023	1.0	null
Appendix adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.373
A549_Tucidinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0258068
A549_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0304809
K562_FLLL32_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0279434
K562_Ellagic acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0352551
A549_Enzastaurin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240894
PMC7616765-EMS198548-supplement-Data_S2.xlsx-3_DEG_2D_and_3D-D9_Up_in_3D_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_CYC116_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132349
PMC8157222__F2	PFOCR Pathway Figure Associations 2024	1.0	null
MCF7_WP1066_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132373
MCF7_Momelotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145856
MCF7_Entacapone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214514
MCF7_Tozasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182193
A549_GSK-LSD1 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020726
PMC4531812-13058_2015_618_MOESM11_ESM.xlsx-TCGA_Sparse_KM-TFAP2B_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Alendronate sodium trihydrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168595
PMC2712453__F7	PFOCR Pathway Figure Associations 2024	1.0	null
K562_CEP-33779_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238977
K562_PCI-34051_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143735
GSE113106_2_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Basal_KLF5_peaks-Nearest_Ensembl_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
Macitentan	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
A549_Resminostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216199
TIMM10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31208
MCF7_Quisinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00888186
A549_Glesatinib(MGCD265)_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182442
K562_AC480_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0398525
PMC10864182-41588_2023_1596_MOESM4_ESM.xlsx-ST12_Significant_Genes_combine-Unnamed_1_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
PPP1R1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48556
K562_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0252721
A549_PD98059_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172653
K562_Meprednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196641
A549_Ofloxacin_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017128
juvenile-onset Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.551
PC3_PROSTATE	CCLE Cell Line Proteomics	1.0	2.59693
GSE186483_6_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0228673
TOCAINIDE	DGIdb Drug Targets 2026	1.0	5.2932
A549_Tie2 kinase inhibitor_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0363456
MCF7_Enzastaurin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.020441
A549_Selisistat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179558
A549_Pracinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130287
MCF7_NVP-BSK805 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0218914
GSE81803,GSE81912_3_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Sodium Phenylbutyrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210079
A549_Aurora A Inhibitor I_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191036
A549_AZD1480_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0255042
MCF7_SL-327_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0266808
MCF7_Roxadustat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0244063
PICK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30064
A549_A-366_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215592
increased T cell derived lymphoma incidence	MGI Mouse Phenotype Associations 2023	1.0	null
K562_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177791
K562_Resveratrol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.026718
PMC8586238-41467_2021_26788_MOESM6_ESM.xlsx-S2A_CDE_genes-S2A_CDE_-_genes_of_the_two_CCD_genes_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
ANAPC16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46085
MCF7_CEP-33779_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159446
K562_SRT1720 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0237035
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_69_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
K562_FLLL32_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.049093
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-Kasumi-1-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_Kasumi-1_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Resminostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166323
A549_Alendronate sodium trihydrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.023586
K562_Linifanib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.025909
PMC8624111__F10	PFOCR Pathway Figure Associations 2024	1.0	null
A549_CUDC-907_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015394
MCF7_MK-0752_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194626
MCF7_Linifanib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0306771
A549_ZM 447439_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161526
GSE127790_6_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6274615__F1	PFOCR Pathway Figure Associations 2024	1.0	null
K562_Tozasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0458689
K562_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0247347
GSE118766_2_v_3_ifng_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147943_5_v_1_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Tucidinostat_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017014
PMC3528779__F6	PFOCR Pathway Figure Associations 2023	1.0	null
GTEx Heart 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	-1.0	-7.85528
PMC4535396__F5	PFOCR Pathway Figure Associations 2023	1.0	null
MCF7_AMG-900_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0104478
UBAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19271
GSE211963_0_v_3_cd200_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ubiquitin-dependent protein catabolic process	GO Biological Process Annotations 2023	1.0	null
PMC6981958__F1	PFOCR Pathway Figure Associations 2023	1.0	null
K562_MC1568_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0244309
A549_Daphnetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0293578
MCF7_Dacinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161016
MCF7_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150672
TECR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05427
K562_Droxinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0259257
K562_AMG-900_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0356671
GSE160083,GSE160084_1_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7405480__F2	PFOCR Pathway Figure Associations 2023	1.0	null
K562_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214312
PMC5303304-13073_2017_407_MOESM3_ESM.xlsx-mycn-sy5y-se_single_24DMSO_vs_2-Table_S2_Genes_differentially_expressed_by_24h_RA_treatment_DE_comparison_with_SY5Y-MYCN_control_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217115_2_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
496100549_FWM_no dementia_TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.22656
K562_Lenalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0288914
K562_GSK-LSD1 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014876
A549_Baricitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0475995
TOP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26126
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.408
MCF7_Tozasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0496908
K562_Ellagic acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0340036
PMC4962316__F5	PFOCR Pathway Figure Associations 2023	1.0	null
MCF7_TAK-901_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161241
MCF7_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.024521
NCOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59399
GSE207978_1_v_0_rai1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9574515-mmc1.xls-THP1_0_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
K562_AG-490_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209868
GEMIN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67732
MCF7_BRD4770_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0301441
A549_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0218117
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.955
MCF7_Glesatinib(MGCD265)_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191466
A549_PFI-1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192984
SKCO1_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.0404
MCF7_Fasudil_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0222247
K562_Crizotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0542425
K562_Lapatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0316914
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.244
GSE157777_2_v_0_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_BMS-911543_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126801
MCF7_CUDC-907_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0109262
GSE148066,GSE157787_9_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Tazemetostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124764
KE39	DepMap CRISPR Gene Dependency	1.0	2.17721
MCF7_MK-5108_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186837
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_HepG2_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
YD8	DepMap CRISPR Gene Dependency	1.0	2.312
MCF7_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0225513
A549_CUDC-907_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197981
PMC11161988-12906_2024_4523_MOESM3_ESM.pdf-72-SIX6_SIX6	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Resminostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0342711
A549_Mocetinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.026117
A549_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016296
K562_CYC116_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0650289
ENGASE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.46454
K562_Tacedinaline_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142238
GSE248045,GSE248046_0_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
embryonic lethality during organogenesis, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
MCF7_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0383682
GSE217115_3_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_AG-490_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018146
MCF7_UNC1999_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.021054
MCF7_Carmofur_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165251
PMC3607232-mmc1.xls-RS411_SEM_common_AF4_MLLN_K79Me-MLL_AF4_H3K79me3_SEM_n_2490_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6677558__F1	PFOCR Pathway Figure Associations 2024	1.0	null
MCF7_Sorafenib Tosylate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135769
KARPAS299	DepMap CRISPR Gene Dependency	1.0	2.42141
MCF7_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190334
K562_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219592
K562_Resminostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200622
A3KAW	DepMap CRISPR Gene Dependency	1.0	2.3371
GSE148066,GSE157787_11_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0286923
MCF7_INO-1001_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.028233
A549_Ki16425_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015219
A549_Tucidinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196499
PMC9825391-41467_2022_35592_MOESM4_ESM.xlsx-MAF_Targeted_Seq_mutations-Unnamed_60_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Lapatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193628
A549_Tofacitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124811
K562_Momelotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181126
GSE148066,GSE157787_0_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RTN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30174
K562_Ellagic acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0397011
MCF7_AZ 960_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0101687
A549_Momelotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153218
PMC2856676__F1	PFOCR Pathway Figure Associations 2024	1.0	null
CARMIL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51432
GTEx BloodVessel 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-11.6847
MCF7_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184721
K562_Disulfiram_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0366109
GSE101537_1_v_3_neurog3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149442_1_v_0_gdpd3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Curcumin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0255738
MCF7_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0235183
K562_AC480_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167099
MCF7_Tacedinaline_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0231429
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.318
MCF7_Cerdulatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0274
PMC12499388-ADVS-12-e01774-s002.xlsx-Table_S1-Table_S1_Differentially_Expressed_Genes_between_wild-type_and_TET3-knockout_PANC-1_cells_TET3	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Ramelteon_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154534
MCF7_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0316771
PMC7480058-95058-2020.08.29.20182899-10.xlsx-1ModuleKeyDrivers-Target_gene_symbol_that_KD_acts_upon_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Childhood disintegrative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.383
K562_Selisistat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149576
PMC12663032-mmc7.xlsx-Supp_T6-Supplemental_Table_6_Dual_treated_vs_vehicle_treated_MSC_top_DEGs_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Melancholic depression	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.955
A549_JNJ-26854165_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0225783
K562_Fulvestrant_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0268805
GSE145323,GSE145324_1_v_0_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_M344_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202318
GSE111102,GSE111105_1_v_5_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
INMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23087
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.035
FLECAINIDE ACETATE	DGIdb Drug Targets 2026	1.0	1.05864
PMC10746608-427_2023_709_MOESM5_ESM.xlsx-SOX2_partners-SOX2_known_protein_partners_according_to_BioGrid_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE89767_2_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMAD2-18955504-HACAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
K562_Streptozotocin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210278
MCF7_Daphnetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166711
K562_Thiotepa_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0279659
PMC3115268__F2	PFOCR Pathway Figure Associations 2023	1.0	null
MCF7_ZM 447439_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0244904
MCF7_IOX2_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.042008
Depressive disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.955
SW1271	DepMap CRISPR Gene Dependency	1.0	2.07309
K562_Avagacestat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0265741
K562_Vandetanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0310722
K562_Tie2 kinase inhibitor_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0274492
PMC8284093__F10	PFOCR Pathway Figure Associations 2024	1.0	null
K562_BMS-536924_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.040534
MCF7_SGI-1776 free base_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0253753
PMC8569351__F2	PFOCR Pathway Figure Associations 2024	1.0	null
PMC12847549-262_2025_4297_MOESM1_ESM.pdf-31-RBPJ_RBPJ	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-Row_names_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE190322,GSE190324_3_v_4_rbm4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3K_Peaks_wtYAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE111102,GSE111105_8_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_TMP195_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0505741
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IGF2BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07177
PMC10248509-Data_Sheet_6.CSV--GSE58294_DE-genes_AND_GSE22255_DE-Genes_NOT_Autophagy_NOT_GSE66724_DE-Genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
A549_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0483008
GSE58724_1_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Gandotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164424
increased uterus tumor incidence	MGI Mouse Phenotype Associations 2023	1.0	null
MCF7_Abexinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209408
K562_Decitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0477693
A549_Cerdulatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0246783
K562_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.02924
MCF7_Meprednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0369597
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.167
K562_AICAR_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.027104
MCF7_S-Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0287835
PMC7598701__F10	PFOCR Pathway Figure Associations 2023	1.0	null
A549_BMS-911543_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131597
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-genes_with_only_SALL4_peaks-Protein-coding_genes_that_show_only_CUT_RUN_peaks_with_2_SALL4_antibodies_and_no_other_antibodies_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
K562_AG-14361_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0293441
A549_ENMD-2076 L-Tartaric acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152067
RBCK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63637
A549_Luminespib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0233983
NCIH1355	DepMap CRISPR Gene Dependency	1.0	2.57182
A549_Cimetidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015742
K562_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164024
FBRS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01844
PMC8160578-JCB_202009147_TableS4.xlsx-E2F1_targets-Genes_n_1867_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Trametinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168131
MCF7_WP1066_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140413
A549_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0335261
PMC12080872-pone.0323227.s004.xlsx-All_3_C-D_YY1_dep-Gene_name_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3367986__F2	PFOCR Pathway Figure Associations 2023	1.0	null
GSE212299_3_v_0_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0229914
GSE214823,GSE214824_3_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Tubastatin A HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187638
A549_Toremifene Citrate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0245824
A549_GSK1070916_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123299
Acute myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.265
MCF7_Tranylcypromine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164365
PMC9574515-mmc2.xls-THP1_0_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0261974
MCF7_Tucidinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129455
A549_UNC1999_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127982
PMC10242764__F7	PFOCR Pathway Figure Associations 2024	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.672
K562_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0369052
MCF7_GSK-LSD1 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198334
MCF7_Altretamine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155964
PMC5009320__F5	PFOCR Pathway Figure Associations 2023	1.0	null
A549_ABT-737_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143067
MCF7_Navitoclax_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0246934
K562_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166828
A549_Dasatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232638
PMC4852799__F1	PFOCR Pathway Figure Associations 2023	1.0	null
HCC2998	DepMap CRISPR Gene Dependency	1.0	2.21706
GSE129725_4_v_0_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WM2664	DepMap CRISPR Gene Dependency	1.0	2.50103
MCF7_RG108_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019194
K562_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0305652
PMC12354803-42003_2025_8643_MOESM2_ESM.xlsx-2w_TP63_positive-Gene_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0519663
increased incidence of induced tumors	MGI Mouse Phenotype Associations 2023	1.0	null
K562_Droxinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131284
K562_Glesatinib(MGCD265)_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0320518
SKNAS	DepMap CRISPR Gene Dependency	1.0	2.46126
NME6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09814
PMC7408589__F12	PFOCR Pathway Figure Associations 2024	1.0	null
PMC3500769-srep00875-s3.xls-GATA3-Time_0_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
A549_CYC116_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0268446
PMC6059697__F11	PFOCR Pathway Figure Associations 2023	1.0	null
K562_AR-42_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015163
A549_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205932
K562_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202771
GI1	DepMap CRISPR Gene Dependency	1.0	2.42653
MCF7_Tranylcypromine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166725
K562_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0360259
MCF7_Carmofur_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198988
A549_EED226_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155857
MCF7_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.020269
K562_Streptozotocin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0235526
PMC7249743__F8	PFOCR Pathway Figure Associations 2023	1.0	null
A549_Belinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0312053
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.087
K562_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0295023
AGMAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02454
K562_Baricitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182687
A549_AMG-900_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143609
PMC3445305__F3	PFOCR Pathway Figure Associations 2023	1.0	null
A549_MC1568_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0336893
PMC3614443__F1	PFOCR Pathway Figure Associations 2023	1.0	null
A549_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187672
MCF7_Epothilone A_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142233
K562_Cerdulatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023696
A549_UNC1999_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210826
PMC3367986__F2	PFOCR Pathway Figure Associations 2024	1.0	null
K562_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0237591
A549_Nintedanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0211574
PMC4844344__F12	PFOCR Pathway Figure Associations 2024	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
A549_ENMD-2076_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175455
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
PMC7403652__F4	PFOCR Pathway Figure Associations 2024	1.0	null
GSE180641_0_v_1_zfp503_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Abexinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141281
A549_Roxadustat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0325292
MCF7_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.027347
A549_Capecitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196686
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-MECP2-fromNode_MECP2	Rummagene Transcription Factor Associations 2026	1.0	null
SF295	DepMap CRISPR Gene Dependency	1.0	2.47135
PROPAFENONE	DGIdb Drug Targets 2026	1.0	1.17627
K562_Vandetanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.022478
K562_Ramelteon_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0365544
K562_Tucidinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0243862
YKG1	DepMap CRISPR Gene Dependency	1.0	2.30194
K562_PF-3845_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236203
MCF7_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210802
K562_S-Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0394233
K562_Alisertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0340516
KAT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31329
MCF7_Belinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141804
NCIH1437	DepMap CRISPR Gene Dependency	1.0	2.29211
K562_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173933
MCF7_GSK-LSD1 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0119943
A549_SB431542_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190964
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_3hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
EVSAT	DepMap CRISPR Gene Dependency	1.0	2.15845
KATOIII	DepMap CRISPR Gene Dependency	1.0	2.56813
NCIH716	DepMap CRISPR Gene Dependency	1.0	2.37352
CCLFPEDS0003T	DepMap CRISPR Gene Dependency	1.0	2.61595
A549_SRT2104_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.02038
GSE146156_1_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148239
MCF7_SB431542_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144792
GSE125782_0_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5742900__F4	PFOCR Pathway Figure Associations 2024	1.0	null
MCF7_Navitoclax_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0103863
Fragile X syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.255
A549_CEP-33779_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158175
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_x_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Ellagic acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188854
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Gene_Name_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170592
MCF7_Toremifene Citrate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122569
MCF7_TGX-221_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0372428
A549_Costunolide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144293
A549_Entacapone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194898
A549_PD173074_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149077
K562_Tazemetostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.028745
A549_Dacinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0120217
A549_MLN8054_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0116041
MM127	DepMap CRISPR Gene Dependency	1.0	2.59252
GSE180200,GSE180201_5_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6656753__F5	PFOCR Pathway Figure Associations 2024	1.0	null
TIMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10209
A549_Entinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0320557
MCF7_WHI-P154_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01512
MCF7_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203458
HTRA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83213
PMC5686903__F2	PFOCR Pathway Figure Associations 2023	1.0	null
MCF7_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146084
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_M344_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154712
GSE147834_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Mocetinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204681
K562_UNC0379_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.037872
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Maraviroc_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227655
PDLIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14445
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
ATP2C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99081
hydrops fetalis	MGI Mouse Phenotype Associations 2023	1.0	null
GSE148066,GSE157787_9_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC2263127-pone.0001816.s001.xls-E2F3_up_Bild-Symbol_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
Pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.766
A549_Amisulpride_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0308702
MCF7_Barasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141048
AR-35650195-DSRCT-HUMAN-MESENCHYMAL-SARCOMA	ChEA Transcription Factor Targets 2022	1.0	null
K562_Temsirolimus_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0499708
MCF7_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218477
MCF7_SNS-314 Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019905
K562_TG101209_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.045005
GSE195582_3_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29127
A549_Danusertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165414
A549_Roxadustat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142772
A549_Barasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190889
A549_UNC1999_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191133
Fanconi anemia complementation group F	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.383
PMC9574515-mmc1.xls-THP1_60_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00974593
NCIN87	DepMap CRISPR Gene Dependency	1.0	2.66665
MCF7_AR-42_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124431
KNDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0543
GSE203308_6_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE237040_6_v_5_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8758994__F3	PFOCR Pathway Figure Associations 2024	1.0	null
K562_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0333402
K562_Pirarubicin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189112
K562_Lapatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212347
K562_Enzastaurin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018583
positive regulation of proteasomal protein catabolic process	GO Biological Process Annotations 2023	1.0	null
MCF7_SRT2104_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150133
UMUC3	DepMap CRISPR Gene Dependency	1.0	2.25378
A549_Vandetanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241758
496100612_HIP_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.16897
GSE184884_6_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Barasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0246999
GSE237040_4_v_5_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Barasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203795
MM383	DepMap CRISPR Gene Dependency	1.0	2.03926
Nephroma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.142
K562_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0201597
PMC3778921__F4	PFOCR Pathway Figure Associations 2023	1.0	null
A549_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.024116
A549_Costunolide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140278
GFER	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47472
A549_JNJ-26854165_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0325241
PMC6138873__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE127790_10_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184884_6_v_5_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3669416-pone.0064838.s005.xls-wTP53-IRF8_IRF8	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Selisistat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182732
CHAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68654
CNIH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26534
Muscle - Skeletal	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.178
K562_Avagacestat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0277004
K562_Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209829
TE1_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	2.78367
K562_BMS-536924_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0340186
A549_Iniparib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149703
GSE148066,GSE157787_0_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Iniparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177218
GTEx Muscle 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	-1.0	-10.6926
A549_Pelitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135509
A549_EED226_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185461
A549_Streptozotocin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015983
PMC6695471__F1	PFOCR Pathway Figure Associations 2024	1.0	null
A549_Tazemetostat_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130205
GSE215351,GSE215794_4_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_12hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE129725_1_v_5_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_UNC0631_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223453
K562_ITSA-1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0239208
A549_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017153
A549_BMS-911543_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0303579
K562_Mercaptopurine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167305
MCF7_Abexinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129072
K562_Azacitidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0509
A549_Resveratrol_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141632
PMC5127598__F5	PFOCR Pathway Figure Associations 2024	1.0	null
K562_Valproic acid sodium salt_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0734279
PMC7002996__F5	PFOCR Pathway Figure Associations 2023	1.0	null
MCF7_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0362852
MCF7_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0307852
K562_Ofloxacin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163526
PMC3528779__F6	PFOCR Pathway Figure Associations 2024	1.0	null
MCF7_WP1066_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0220754
GSE125782_3_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Navitoclax_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0363072
PMC4342183__F4	PFOCR Pathway Figure Associations 2024	1.0	null
MCF7_Givinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132804
GSE217694_3_v_2_pold1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6694122-41467_2019_11591_MOESM7_ESM.xlsx-a_GATA2_R361_Subclone_4_DEGs-SubGene_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Decitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0261848
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
A549_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219239
MCF7_KW-2449_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168018
A549_G007-LK_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0274714
MCF7_Pelitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0272199
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Up_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.182
PMC9404532-NIHMS1788564-supplement-Supplementary_Tables_1-8.xlsx-Supp_Table_6-MYC_UP_V1_DN_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
MRTO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57102
A549_Abexinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.011036
GSE112761,GSE112767_4_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5527282-ncomms16041-s3.xlsx-M_LPS_-_gene_signature-Supplementary_Data_2_Full_gene_list_of_M_LPS_-_signatures_as_defined_in_figure_3_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE87404,GSE87812_1_v_3_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE196699_2_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_PJ34_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129872
PMC12619835-41467_2025_66007_MOESM13_ESM.xlsx-Sheet1-Basal_like_KLF5_peaks_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
A549_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150861
MCF7_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192917
A549_Alisertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0226941
PMC7457511__F9	PFOCR Pathway Figure Associations 2024	1.0	null
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.262
MCF7_Mocetinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0312682
A549_PFI-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149991
170MGBA	DepMap CRISPR Gene Dependency	1.0	2.72964
PMC9506007__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Cytosporone B	DeepCoverMOA Drug Mechanisms of Action	1.0	0.29
PMC8423434-mmc7.xlsx-SOX2_Primed-Genes_n_3042_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10773028-40364_2023_552_MOESM2_ESM.xlsx-Variants_sheet-TFT_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9883437-41467_2023_36150_MOESM4_ESM.xlsx-Chromatin_Regulators-AIRE_AIRE	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH2110_LUNG	CCLE Cell Line Proteomics	1.0	4.44861
MCF7_Roscovitine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150949
MCF7_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240177
A549_Tozasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179672
K562_Alvespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170296
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.115
MRFAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18022
K562_Danusertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0288265
GSE196699_2_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
THOC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17843
MCF7_Panobinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00784253
GSE136622_6_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_G007-LK_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147332
MCF7_Navitoclax_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152357
K562_MC1568_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01926
A549_PJ34_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0466374
MCF7_Busulfan_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0262553
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
K562_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.026054
MDAMB361	DepMap CRISPR Gene Dependency	1.0	2.39982
K562_Ivosidenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0243897
MCF7_BMS-265246_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127004
positive regulation of ubiquitin-dependent protein catabolic process	GO Biological Process Annotations 2023	1.0	null
PMC5039670__F4	PFOCR Pathway Figure Associations 2023	1.0	null
K562_Rucaparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.044721
K562_Maraviroc_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0235222
CACNG6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14547
K562_AZ 960_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184754
GSE146156_2_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Pirarubicin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.03555
A549_Pelitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210239
A549_UNC1999_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0227942
A549_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0220839
A549_AT9283_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0204111
PMC9825391-41467_2022_35592_MOESM4_ESM.xlsx-MAF_Targeted_Seq_mutations-Unnamed_47_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
Autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.786
K562_Mesna_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0250396
A549_JNJ-7706621_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157125
MCF7_Trichostatin A_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0111302
KCNK17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14331
K562_Temsirolimus_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0267083
GSE214823,GSE214824_4_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Pracinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0105182
PMC7672319-mmc3.xlsx-Senescence_MSigDB62-KEGG_P53_SIGNALING_PATHWAY_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Raltitrexed_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169077
K562_Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.021374
response to ionizing radiation	GO Biological Process Annotations 2023	1.0	null
A549_NVP-BSK805 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193776
MCF7_Iniparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0220195
PMC1307593__F2	PFOCR Pathway Figure Associations 2023	1.0	null
PMC4066587__F2	PFOCR Pathway Figure Associations 2023	1.0	null
MCF7_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0226372
DANG	DepMap CRISPR Gene Dependency	1.0	2.36337
Schizophrenia 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.246
MCF7_Lomustine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0271453
MCF7_Celecoxib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191124
A549_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0266802
MCF7_Cediranib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126819
increased tumor incidence	MGI Mouse Phenotype Associations 2023	1.0	null
A549_A-366_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140439
K562_AMG-900_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0360097
GSE160246_0_v_7_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182963
PMC4066587__F2	PFOCR Pathway Figure Associations 2024	1.0	null
MCF7_SRT2104_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0275201
K562_KW-2449_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236193
RCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09969
MCF7_Tucidinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149385
MCF7_Roxadustat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168258
PMC8437976-41416_2021_1470_MOESM2_ESM.xls-List_of_MAF_in_SNP_Rectum-Hugo_Symbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
EXOSC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30051
PMC8384902-mmc5.xlsx-H128_PROX1_ChIP-Symbol_PROX1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_MK-0752_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0233246
A549_Alisertib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164332
PMC10920960-mmc3.pdf-0-AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
K562_CUDC-907_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202273
GSE228181_2_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE227634,GSE228381_0_v_7_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_M344_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148723
A549_Triamcinolone Acetonide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0117204
CLINT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58211
A549_Givinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147332
A549_Meprednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0227891
MLLT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33969
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.246
PMC7593653__F5	PFOCR Pathway Figure Associations 2023	1.0	null
K562_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0385021
K562_PHA-680632_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0325207
PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_12_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Glesatinib(MGCD265)_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0299286
496100604_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.11037
PMC7002996__F5	PFOCR Pathway Figure Associations 2024	1.0	null
K562_CEP-33779_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165729
A549_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.043054
PMS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60223
Actonel	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.27
A549_2-Methoxyestradiol_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128781
PMC8745615__F3	PFOCR Pathway Figure Associations 2024	1.0	null
A549_AZD1480_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0369818
GSE117042_1_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Lomustine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0445932
K562_YM155_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210981
PMC8423434-mmc7.xlsx-SOX2_HENSM-Genes_n_2733_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_HepG2_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198201
K562_MC1568_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0393698
K562_Costunolide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0214395
K562_Roxadustat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0259756
GSE148066,GSE157787_2_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE65617_0_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_JNJ-26854165_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0309329
PMC11627398-pone.0315219.s005.xlsx-MTF1-symbol_MTF1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7999361__F2	PFOCR Pathway Figure Associations 2024	1.0	null
A549_Cimetidine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182148
MCF7_Raltitrexed_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0291268
MCF7_Ki8751_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121902
A549_G007-LK_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0235695
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO Biological Process Annotations 2023	1.0	null
increased testicular teratoma incidence	MGI Mouse Phenotype Associations 2023	1.0	null
K562_AZD1480_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.027886
A549_Celecoxib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019897
Angelman syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.635
K562_Roscovitine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190495
PMC11067031-pnas.2317690121.sd03.xlsx-gene_list_-_2022-04-13T081711_1-Differentially_expressed_genes_between_PML_RARA_GFP_vs_Empty_vector_GFP_mouse_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10570830__F2	PFOCR Pathway Figure Associations 2024	1.0	null
MCF7_Trichostatin A_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0250915
GSE252857_1_v_0_prednisone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_AC480_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127489
K562_Motesanib Diphosphate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0326581
PMC8881509__F7	PFOCR Pathway Figure Associations 2024	1.0	null
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.226
IZUMO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25234
A549_Ivosidenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0359718
WM1799_SKIN	CCLE Cell Line Proteomics	1.0	2.48291
MCF7_Triamcinolone Acetonide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0113729
MKN45_STOMACH	CCLE Cell Line Proteomics	1.0	2.95394
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_R_species_not_found_in_common_genes_of_LF_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Divalproex Sodium_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183653
A549_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0288138
MCF7_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161198
MCF7_Rucaparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179864
GSE147664_0_v_1_arid1b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_BMS-754807_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145969
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
K562_Temsirolimus_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.029956
BCATc-In2	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.28
PMC4773428-ncomms10751-s5.xlsx-S_Table_4-Supplementary_Data_4_RUNX1_responsive_genes_in_the_presence_and_absence_of_estradiol_E2_in_MCF7_cells_FC_1_5_p_0_05_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Raltitrexed_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0268648
K562_Celecoxib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0253361
K562_BMS-265246_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0275766
MCF7_Vandetanib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121061
A549_Selisistat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0284458
MCF7_Pelitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148549
GSE254848_4_v_3_ptges_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Ramelteon_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020229
RAB31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20164
RVH421	DepMap CRISPR Gene Dependency	1.0	2.40914
SMAD4-19686287-HACAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC7758031__F1	PFOCR Pathway Figure Associations 2023	1.0	null
MCF7_ITSA-1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131734
MCF7_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0479393
MCF7_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0120166
K562_Danusertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159375
A549_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0259763
K562_ENMD-2076 L-Tartaric acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0398494
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_97_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
proteasomal protein catabolic process	GO Biological Process Annotations 2023	1.0	null
K562_Capecitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138527
496100349_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05937
PMC10039784__F1	PFOCR Pathway Figure Associations 2024	1.0	null
MCF7_TG101209_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152376
A549_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0339986
A549_Fasudil_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0279031
MCF7_Lenalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166444
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.357
K562_Tozasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0221254
MCF7_Cimetidine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0271226
Female reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.268
A549_Roscovitine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164207
K562_Fluorouracil_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0235012
A549_Obatoclax Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.029079
A549_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184701
A549_PF-573228_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215598
GSE169697,GSE169725_1_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190097
MCF7_Dacinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00895866
A549_A-366_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.025633
A549_Pirarubicin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184396
K562_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0409845
K562_PF-3845_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180585
MCF7_Costunolide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.031431
GSE203308_9_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Aminoglutethimide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01446
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
decreased body weight	MGI Mouse Phenotype Associations 2023	1.0	null
GSE148066,GSE157787_8_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Tubastatin A HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0341343
K562_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0457989
PMC4852799__F1	PFOCR Pathway Figure Associations 2024	1.0	null
A549_Belinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206963
MCF7_ABT-737_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0272778
MCF7_Patupilone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143013
Metabolism of proteins	Reactome Pathways 2024	1.0	null
GSE136869_1_v_0_lpar2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157591
GSE214442_0_v_1_pak4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Decitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203167
K562_Zileuton_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.024011
K562_Alendronate sodium trihydrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0295466
MCF7_SRT1720 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0287947
PMC3669416-pone.0064838.s001.xls-mHTT-POU5F1_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_ENMD-2076_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187079
PMC4663793__F3	PFOCR Pathway Figure Associations 2024	1.0	null
A549_Obatoclax Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174681
A549_Dacinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0114893
K562_Cimetidine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172814
A549_ZM 447439_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203638
PMC7457511__F9	PFOCR Pathway Figure Associations 2023	1.0	null
MCF7_Aurora A Inhibitor I_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173208
MCF7_Busulfan_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162504
PMC5263239-mmc2.xls-THP-1_-_MLL-AF9-Non-spreading_targets_gene_names_1900_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
496100572_HIP_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.0986
K562_JQ1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186262
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
K562_PHA-680632_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0303811
A549_Anacardic Acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0279795
A549_TMP195_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158654
K562_TMP195_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0279375
PMC8851354-Table_6.xlsx-STAT3-bound_genes_GM12878-Supplementary_Table_6_STAT3-bound_unique_genes_in_GM12878_cells_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.281
MCF7_S-Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0268113
K562_Momelotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0367804
MCF7_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0231221
KP1N	DepMap CRISPR Gene Dependency	1.0	2.25688
K562_SGI-1776 free base_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.031903
PMC8321552__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE196671_6_v_8_obox4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_BMS-911543_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161005
K562_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.028289
MCF7_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165804
K562_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171531
Appendix cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.044
A549_Trichostatin A_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190598
A549_PFI-1_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206214
MCF7_IOX2_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0338378
MCF7_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.04008
A549_Capecitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0319222
K562_Ki8751_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0391559
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.09
GSE203158_1_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Andarine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147636
GSE160083,GSE160084_2_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Linifanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206454
TIMELESS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0107
K562_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0362005
K562_Triamcinolone Acetonide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125286
DBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2331
PMC9005964-DataSheet_1.xlsx-Sheet1-FOXO1_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE220520_1_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_BMS-265246_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0201575
MCF7_Resminostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139246
K562_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171298
A549_Divalproex Sodium_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207833
A549_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128915
MCF7_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165899
PMC12240782-Table3.xlsx-Sheet1-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Alisertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147971
K562_ENMD-2076 L-Tartaric acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0302098
PMC3022822-1471-2164-12-11-S10.XLS-Suppl_7_newLN229_SOX2_KO_MOCK_2-Unnamed_1_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_BREAST	CCLE Cell Line Proteomics	1.0	3.73424
GSE112761,GSE112767_1_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4336944-srep08530-s3.xls-1_Halo-JUN_FDR_0_01-Unnamed_0_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Trametinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141732
A549_PCI-34051_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167717
A549_Alendronate sodium trihydrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0250995
MCF7_Hesperadin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0237487
LS513	DepMap CRISPR Gene Dependency	1.0	2.6811
A549_Pelitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183436
ZBTB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20766
A549_BRD4770_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0371654
PMC8190596-mmc2.xlsx-RUNX1_mut-RUNX1_mut_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0267554
PMC3669416-pone.0064838.s001.xls-mHTT-RELA_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
BUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92074
K562_Bisindolylmaleimide IX_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0245955
MCF7_Trichostatin A_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162039
MCF7_Sodium Phenylbutyrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0203931
GSE220520_3_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_ENMD-2076 L-Tartaric acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120801
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_ZR75_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
COV413A	DepMap CRISPR Gene Dependency	1.0	2.51056
MCF7_Selisistat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015146
A549_Carmofur_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0342615
K562_Momelotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170587
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.268
K562_Luminespib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164509
PMC10641274-mmc2.xlsx-FOXK1_Insulin-SYMBOL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
PACADD165	DepMap CRISPR Gene Dependency	1.0	2.02713
GSE114992,GSE114993_8_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100501_PCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.28295
MCF7_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156757
GSE231648_0_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.82832
PMC5742900__F4	PFOCR Pathway Figure Associations 2023	1.0	null
A549_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0299555
GSE100316_7_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PUS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42042
MCF7_Panobinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137216
MCF7_Quisinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157022
GSE254517_3_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1901
A549_Mesna_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138841
PMC7249743__F8	PFOCR Pathway Figure Associations 2024	1.0	null
BCAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24248
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Regorafenib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0119061
K562_Danusertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0347385
PMC7261917-Table_10.xlsx-P53_signaling_pathway-gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
A549_JNJ-7706621_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170139
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Unnamed_13_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10773028-40364_2023_552_MOESM1_ESM.xlsx-Variants_sheet-TFT_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7598701__F10	PFOCR Pathway Figure Associations 2024	1.0	null
PMC4300045__F3	PFOCR Pathway Figure Associations 2023	1.0	null
MCF7_Abexinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145204
SNU423_LIVER	CCLE Cell Line Proteomics	1.0	2.19883
MCF7_Glesatinib(MGCD265)_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169265
K562_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0228379
K562_AZ 960_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227483
PMC10852255-pone.0297872.s004.xlsx-LPS_UPstream-Upstream_Regulator_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Maraviroc_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169261
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
A549_Tanespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.010539
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.069
PMC9928584-41556_2022_1059_MOESM3_ESM.xlsx-Table_8-Supplementary_Table_8_ETV6-repressed_genes_defined_by_dTAG_at_72_hours_ETV6	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Danusertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0255786
A549_Aurora A Inhibitor I_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.013094
A549_TMP195_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197789
MCF7_Nintedanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0370713
Asperger syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.197
A549_ZM 447439_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0330642
MCF7_Regorafenib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0293447
K562_Droxinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.022103
K562_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0327153
GSE118617,GSE118619_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Azacitidine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0113287
K562_JNJ-26854165_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0273962
PMC6424098-mmc5.xlsx-CEBP_Binder-Gene_names_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8049026__F2	PFOCR Pathway Figure Associations 2023	1.0	null
JIMT1	DepMap CRISPR Gene Dependency	1.0	2.08942
K562_JNJ-7706621_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0466207
NDC80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12394
PMC2883591-pgen.1000979.s003.xls-NRSF_GENELISTS_WitOut_GeneSig_g-Supplemental_Table_3_REST	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3631012__F1	PFOCR Pathway Figure Associations 2024	1.0	null
K562_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150672
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.658
MCF7_XAV-939_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019138
GSE188870,GSE188871_0_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_SB431542_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207453
MCF7_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0228352
ARSD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1094
A549_Flavopiridol HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130661
MCF7_Rucaparib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0113383
K562_Azacitidine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163918
MCF7_AR-42_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015196
GSE160246_9_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0248991
K562_Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0246607
PMC11474056-pnas.2404841121.sd01.xlsx-Supplemental_Table_8_Fig1G-H-Supplemental_Table_8_Transcriptomic_overlap_between_LPS_and_Sepsis_and_or_Tuberculosis_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
K562_BMS-911543_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0280945
A549_Alendronate sodium trihydrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0285005
GSE133505_5_v_4_myf6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Tofacitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236183
PMC5982776__F4	PFOCR Pathway Figure Associations 2024	1.0	null
496100622_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.1805
PMC9574515-mmc2.xls-THP1_60_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-RT4-FOXA1_peaks_Context1_2-Nearest_Ensembl_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE248858_4_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Roxadustat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0338502
Carbamazepine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
PMC5009320__F5	PFOCR Pathway Figure Associations 2024	1.0	null
MCF7_ENMD-2076 L-Tartaric acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0237443
PMC4262781__F2	PFOCR Pathway Figure Associations 2024	1.0	null
K562_INO-1001_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0284841
A549_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166771
GSE146894_3_v_8_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF429	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.346
A549_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165345
PMC9553959__F2	PFOCR Pathway Figure Associations 2024	1.0	null
K562_TGX-221_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0286445
MCF7_TAK-901_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142626
MCF7_Ellagic acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0326439
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_1hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-RT4-FOXA1_peaks_Context1_2-Gene_Name_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
K562_GSK J1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015464
A549_Fulvestrant_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159045
K562_Roscovitine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017753
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Resminostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0265933
K562_Tofacitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0273665
A549_Roxadustat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134034
A549_Gandotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151406
MCF7_Ki8751_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0412498
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.247
K562_WP1066_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158799
PMC6981958__F1	PFOCR Pathway Figure Associations 2024	1.0	null
K562_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0336904
GSE157555,GSE157556_4_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
A549_Tacedinaline_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165905
FUT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37219
PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-SP1_mod_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Resveratrol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155914
A549_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176491
K562_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0312406
K562_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193104
PMC4091570__F1	PFOCR Pathway Figure Associations 2023	1.0	null
K562_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021311
PMC8755441-mmc3.xlsx-IRF7-Up-ezh2_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
TP53-16413492-CHIP-PET-HCT116-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_PF-3845_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.041945
A549_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0393413
MCF7_AICAR_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167728
PCGF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13278
K562_BRD4770_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163395
RVH421SKINFV1	DepMap CRISPR Gene Dependency	1.0	2.65281
PMC6176282__F9	PFOCR Pathway Figure Associations 2024	1.0	null
PMC7593653__F5	PFOCR Pathway Figure Associations 2024	1.0	null
SLC43A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03362
PMC3976861__F2	PFOCR Pathway Figure Associations 2024	1.0	null
K562_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145545
PMC9437808-mmc3.xlsx-IPA_Upstream_regulators-IPA_Upstream_regulator_analysis_Up_regulated_genes_following_LPS_treatment_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
A549_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0248461
SMAD3-18955504-HACAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC5982776__F4	PFOCR Pathway Figure Associations 2023	1.0	null
GSE88819_7_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Tazemetostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0119717
PDRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44822
Chromosomal deletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
PMC6695471__F1	PFOCR Pathway Figure Associations 2023	1.0	null
A549_MK-5108_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224863
K562_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199466
PMC9314667-Table_1.xlsx-Regulons-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Trichostatin A_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177783
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
GSE104508_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
MCF7_AG-490_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0325638
PMC3575449__F1	PFOCR Pathway Figure Associations 2024	1.0	null
ZNF257	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08074
PMC7262827__F5	PFOCR Pathway Figure Associations 2023	1.0	null
K029AX	DepMap CRISPR Gene Dependency	1.0	2.12393
PMC8033524-EMMM-13-e13162-s004.xlsx-d_GREAT_on_NFIB_bound-genes_HF-Unnamed_0_NFIB	Rummagene Transcription Factor Associations 2026	1.0	null
A549_PCI-34051_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176919
MCF7_Rigosertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150107
MCF7_Decitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205806
A549_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0317777
GSE160246_0_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Regorafenib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232775
TSPAN14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40616
A549_Roxadustat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142097
PMC5468232__F12	PFOCR Pathway Figure Associations 2023	1.0	null
A549_MK-0752_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0380979
MCF7_Mocetinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0268379
A549	DepMap CRISPR Gene Dependency	1.0	2.34159
A549_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185313
MCF7_Daphnetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124732
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.32
GSE111138,GSE111149_1_v_0_runx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12941
PMC12242962-BLOODA_ADV-2024-014986-mmc1.pdf-2-NCOA3_NCOA3	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Aurora A Inhibitor I_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0270506
PMC7758031__F1	PFOCR Pathway Figure Associations 2024	1.0	null
CEPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84497
ISO-1	DeepCoverMOA Drug Mechanisms of Action	1.0	0.31
A549_Thiotepa_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0343502
A549_BRD4770_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0234935
MCF7_GSK J1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017369
K562_M344_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0373351
CAKI2_KIDNEY	CCLE Cell Line Proteomics	1.0	6.97517
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.207
A549_Rigosertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0302578
K562_Iniparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227965
K562_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.038122
MCF7_AT9283_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194325
K562_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0415488
GSE196699_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160246_9_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.116
A549_Sorafenib Tosylate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166061
TPMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61658
MCF7_Barasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0332954
MCF7_Anacardic Acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0204245
USPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34289
PMC7403652__F4	PFOCR Pathway Figure Associations 2023	1.0	null
PMC6305196__F9	PFOCR Pathway Figure Associations 2024	1.0	null
Major depressive disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.955
MCF7_FLLL32_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186921
A549_SL-327_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205743
GSE196671_5_v_0_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_MC1568_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0251424
PMC2712453__F7	PFOCR Pathway Figure Associations 2023	1.0	null
A549_Valproic acid sodium salt_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0240291
MCF7_Pelitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110548
K562_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192702
A549_Ofloxacin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0229935
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.251
GMIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25946
A549_WP1066_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163147
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
MCF7_Tanespimycin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123639
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_13_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Filgotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181967
MCF7_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0258006
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.228
K562_GSK1070916_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0225192
K562_Gandotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177325
Ovary adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.203
K562_AG-490_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163524
MCF7_AZ 960_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0226919
PMC8047323-Table_2.xlsx-LPS_PMMA_T24-GeneSymbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ACADM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15327
K562_Ki8751_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0252177
MCF7_Divalproex Sodium_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0245066
K562_AMG-900_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206974
K562_PHA-680632_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180602
GSE67266_7_v_3_etoposide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015396
GSE60837_2_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180843
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.678
K562_Enzastaurin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180448
A549_BMS-536924_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0255991
A549_Dacinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215785
K562_Belinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.030961
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.093
Cul4-RING E3 ubiquitin ligase complex	GO Cellular Component Annotations 2023	1.0	null
MCF7_Crizotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143258
K562_IOX2_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150733
A549_WHI-P154_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0327472
K562_BRD4770_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0217745
GSE198254_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.232
FAM220A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02355
IGR39	DepMap CRISPR Gene Dependency	1.0	2.70224
Cell Cycle Checkpoints	Reactome Pathways 2024	1.0	null
MCF7_Alvespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124294
anemia	MGI Mouse Phenotype Associations 2023	1.0	null
A549_MC1568_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150926
GSE148066,GSE157787_5_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Ofloxacin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019484
MCF7_Droxinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0273685
NICN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07455
MCF7_Temsirolimus_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161538
PMC6319725-pone.0204197.s006.xlsx-Table_S2-S2_TABLE_-_Operon_Expression_and_SOM_clustering_data_for_Gene_Set_identified_by_ANOVA_p_0_005_1005_genes_FDR_8_8_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Fasudil_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174548
K562_ENMD-2076 L-Tartaric acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0409925
MCF7_BMS-536924_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0355078
Autodegradation of the E3 ubiquitin ligase COP1	Reactome Pathways 2024	1.0	null
PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-STAT3_mod_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.229
K562_PFI-1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151525
PMC4336944-srep08530-s3.xls-1_Halo-JUN_FDR_0_01-Unnamed_33_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE130690,GSE130692_2_v_0_sirt6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100390_PCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.37811
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3K_Peaks_wtYAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_15_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
AS-605240	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
K562_Bisindolylmaleimide IX_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149155
GSE131161_2_v_6_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180200,GSE180201_15_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LS180	DepMap CRISPR Gene Dependency	1.0	2.37372
PMC9510835-Table_2.docx-79-ARID3A_ARID3A	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_MK-0752_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151624
PMC4300045__F3	PFOCR Pathway Figure Associations 2024	1.0	null
A549_Obatoclax Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0451249
SRXN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01791
A549_Resveratrol_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019812
MCF7_CUDC-101_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186599
K562_PF-3845_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0234361
A549_Luminespib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172593
A549_Alvespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199948
GSE148066,GSE157787_3_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Autistic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.842
A549_Ruxolitinib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128507
K562_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171327
GSE241701_1_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Childhood fibrosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.076
MCF7_Flavopiridol HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118156
K562_WP1066_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159193
K562_Trichostatin A_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167505
PMC6694122-41467_2019_11591_MOESM7_ESM.xlsx-c_GATA2_R361_whole_sample_DEGs-Gene_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Raltitrexed_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00986866
PMC8618018__F2	PFOCR Pathway Figure Associations 2024	1.0	null
K562_Andarine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0448371
A549_Streptozotocin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206573
K562_Raltitrexed_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202056
A549_Decitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0285669
K562_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213981
A549_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0227084
GSE111102,GSE111105_4_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.955
PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_Myeloid-Unnamed_1_RAG1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Mesna_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0255025
proteasome-mediated ubiquitin-dependent protein catabolic process	GO Biological Process Annotations 2023	1.0	null
A549_FLLL32_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0376591
MCF7_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0290348
K562_Entacapone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0420198
MCF7_Dasatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171095
K562_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0296158
MCF7_PJ34_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0340167
PMC4342183__F4	PFOCR Pathway Figure Associations 2023	1.0	null
GSE111102,GSE111105_1_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Nilotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0249343
SNU387	DepMap CRISPR Gene Dependency	1.0	2.30036
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
A549_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0308103
PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_9_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7925916__F3	PFOCR Pathway Figure Associations 2023	1.0	null
ubiquitin-like protein transferase activity	GO Molecular Function Annotations 2023	1.0	null
A549_MLN8054_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017722
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.207
A549_Linifanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195207
GSE140200_1_v_0_trim59_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_CEP-33779_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150058
PMC9336464-Table_4.docx-0-REL_REL	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_AZ 960_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121701
K562_SL-327_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.02549
A549_Momelotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0262512
MCF7_Fasudil_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153909
PMC3631012__F1	PFOCR Pathway Figure Associations 2023	1.0	null
Post-translational protein modification	Reactome Pathways 2024	1.0	null
MCF7_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0335328
K562_Regorafenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0578392
K562_S-Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0284175
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.753
MCF7_AR-42_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0089494
PMC3500769-srep00875-s3.xls-AP1-Time_0_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.029373
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
MCF7_PF-3845_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0250328
K562_A-366_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0219249
K562_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0435577
K562_Hesperadin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.032833
CCIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14867
A549_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236168
A549_Divalproex Sodium_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.021082
HSD17B7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5532
NCIH2126_LUNG	CCLE Cell Line Proteomics	1.0	2.59968
PANC1	DepMap CRISPR Gene Dependency	1.0	2.16206
A549_Tacedinaline_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.021014
PMC3799442-supp_gkt678_nar-01667-h-2013-File013.xlsx-ST1-EWS-FLI1_modulated_probesets_and_selected_by_GO_terms_cell_cycle_and_apoptosis_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
PMC9604348__F10	PFOCR Pathway Figure Associations 2024	1.0	null
GSE144796_3_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE87144_3_v_1_rorc_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0377237
K562_PFI-1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153201
PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_10_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9996951-40659_2023_417_MOESM3_ESM.xlsx-Osteo_vs_MSC_Array2_hypo_er_txt-2_UCSC_NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE89767_4_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TAF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24109
PMC6941077__F2	PFOCR Pathway Figure Associations 2023	1.0	null
K562_Filgotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0203114
IGFLR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7619
K562_Entacapone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0303645
MCF7_AC480_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159563
A549_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0298232
SHP77	DepMap CRISPR Gene Dependency	1.0	2.37342
K562_Carmofur_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209047
MCF7_Cimetidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021762
K562_Glesatinib(MGCD265)_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0245373
K562_Tanespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0362158
MCF7_Gandotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146032
MCF7_KW-2449_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158807
PMC6138873__F1	PFOCR Pathway Figure Associations 2024	1.0	null
496100444_HIP_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.66715
HS6ST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49893
K562_Resveratrol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195676
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
USP35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0049
K562_Nintedanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152124
MCF7_Hesperadin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206244
PMC5515284__F7	PFOCR Pathway Figure Associations 2024	1.0	null
PMC6059697__F11	PFOCR Pathway Figure Associations 2024	1.0	null
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_InDel-F5-Pneo-r__CIC-1n_h-r__CIC-2n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_JNJ-26854165_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136092
PMC9753996-jci-132-160767-s182.xlsx-IRF4_assciated-ABCA7_IRF4	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH727	DepMap CRISPR Gene Dependency	1.0	2.23532
A549_Ki8751_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0278704
A549_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188618
PMC10079688-41467_2023_37633_MOESM7_ESM.xlsx-IP_JUN_after_pona_treatment-Supplementary_Data_4_List_of_interactors_of_JUN_identified_by_label-free_quantitative_proteomics_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
SNU601	DepMap CRISPR Gene Dependency	1.0	2.45115
MCF7_Dasatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167933
K562_MK-0752_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0497736
GSE228181_3_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Mercaptopurine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194119
PMC9882185-media-4.xlsx-Neuron_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
p53-Dependent G1/S DNA damage checkpoint	Reactome Pathways 2024	1.0	null
K562_Ki16425_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0316959
A549_G007-LK_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209037
QUININE	DGIdb Drug Targets 2026	1.0	1.17627
MCF7_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0399994
PMC6617733__F1	PFOCR Pathway Figure Associations 2024	1.0	null
MCF7_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154559
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Unnamed_13_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8198665-ijms-22-05754.nxml--E3_Ligase_DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
LIN7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53114
GSE148066,GSE157787_2_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Cimetidine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227191
GSE129186,GSE129223_0_v_1_aicda_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6532413__F3	PFOCR Pathway Figure Associations 2023	1.0	null
MCF7_INO-1001_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168753
A549_Barasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197328
ASH3	DepMap CRISPR Gene Dependency	1.0	2.43999
PMC3879300-pone.0084292.s002.xlsx-SPD_dataset-Gene_symbol_HOXD13	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Aurora A Inhibitor I_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195754
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_TMP195_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0335858
K562_Curcumin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0327271
MCF7_Ofloxacin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0391696
K562_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.045761
A549_AR-42_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209007
GSE186707_1_v_0_hdac4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Ki16425_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198444
GSE168596_1_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
3,5-Dichlorosalicylic acid	DeepCoverMOA Drug Mechanisms of Action	1.0	0.45
Myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.219
GSE206270_2_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141703
K562_Flavopiridol HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204269
A549_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0349977
MCF7_Obatoclax Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124632
belly spot	MGI Mouse Phenotype Associations 2023	1.0	null
A549_Panobinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0102332
A549_Entinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0244162
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TRIP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3876
ubiquitin-protein transferase activity	GO Molecular Function Annotations 2023	1.0	null
A549_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159593
A549_AT9283_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0294995
PMC4965087__F2	PFOCR Pathway Figure Associations 2024	1.0	null
K562_Mercaptopurine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.022751
MCF7_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136106
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.087
K562_Bisindolylmaleimide IX_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188837
T24_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	2.90955
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Baboon_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148066,GSE157787_5_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney cortex disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
KP3	DepMap CRISPR Gene Dependency	1.0	2.09789
X-linked dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
PMC9882185-media-4.xlsx-Neuron_KD-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8674203__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE203158_5_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11166884-mmc4.xlsx-Table_S3-Table_S3_proinflammatory-EC2_comparison_between_WT_and_TG_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Crizotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0340598
A549_RG108_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185317
A549_MC1568_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0267059
PSMD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55276
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.371
MCF7_G007-LK_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0437563
K562_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0231936
PMC5516996__F3	PFOCR Pathway Figure Associations 2023	1.0	null
GSE123372,GSE123373_1_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5700962__F8	PFOCR Pathway Figure Associations 2024	1.0	null
MCF7_PF-573228_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.023285
PMC12005766-ADVS-12-2413120-s003.xlsx-VENN1-Table_S6_related_to_Figure_S6D_List_of_overlapping_DEGs_with_the_E3_or_DUB_gene_set_from_the_iUUCD_2_0_database_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7813639__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE214823,GSE214824_3_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
A549_ITSA-1_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143199
PMC7999361__F2	PFOCR Pathway Figure Associations 2023	1.0	null
MCF7_Momelotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0251347
PMC3440220__F2	PFOCR Pathway Figure Associations 2023	1.0	null
GSE203308_4_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SHP77_LUNG	CCLE Cell Line Proteomics	1.0	4.46851
K562_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0250252
HS936T	DepMap CRISPR Gene Dependency	1.0	2.72672
UPMD1	DepMap CRISPR Gene Dependency	1.0	2.478
GSE222574_0_v_2_lmna_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
G1/S DNA Damage Checkpoints	Reactome Pathways 2024	1.0	null
FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
496100443_HIP_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.27208
A549_Hesperadin_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.017953
496100407_FWM_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.10376
HCC1954_BREAST	CCLE Cell Line Proteomics	1.0	3.23728
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_24hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
K562_PD98059_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016614
PROCAINAMIDE	DGIdb Drug Targets 2026	1.0	1.7644
A549_Momelotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0271125
K562_ENMD-2076_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0274152
A549_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158662
K562_Hesperadin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133302
GTEx Muscle 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-9.51743
GSE196699_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Decitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159564
A549_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144839
PMC7925916__F1	PFOCR Pathway Figure Associations 2023	1.0	null
increased histiocytic sarcoma incidence	MGI Mouse Phenotype Associations 2023	1.0	null
A549_Flavopiridol HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020719
GSU	DepMap CRISPR Gene Dependency	1.0	2.13492
GSE254517_2_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_JQ1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152682
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
K562_Tanespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0324302
MCF7_Veliparib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0306401
A549_S3I-201_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152946
A549_Temsirolimus_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138333
K562_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163932
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.205
PMC4262781__F2	PFOCR Pathway Figure Associations 2023	1.0	null
GSE130383_2_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186483_1_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156989
MCF7_Cerdulatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0353326
K562_Navitoclax_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176955
PMC11409756-13062_2024_533_MOESM1_ESM.xlsx-Sheet1-Table_S1_Differentially_expressed_genes_DEGs_regulated_by_ZFP64_through_mRNA-seq_ZFP64	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Momelotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194767
K562_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148532
PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
NPPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79456
GSE117042_0_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017627
PMC8995879-Table_1.xlsx-exome_variants_MAF_0_01-Gencode_34_hugoSymbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0291487
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.105
A549_FLLL32_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125279
MCF7_AC480_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149108
A549_Ofloxacin_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174331
MCF7_Luminespib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165694
SKMEL24	DepMap CRISPR Gene Dependency	1.0	2.7611
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Baboon_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
TNIK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06322
K562_Bosutinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.022482
K562_MK-0752_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0269243
K562_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0306942
lethality throughout fetal growth and development, incomplete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
A549_Sorafenib Tosylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0281468
PMC10154349-41418_2023_1142_MOESM6_ESM.xlsx-Sheet1-Supplementary_data_3_Genes_positively_correlated_with_HOXC13-AS_in_skin_granular_cells_correlation_coefficients_cor_0_FDR_0_05_HOXC13	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Hesperadin_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.017908
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL2-Unnamed_0_TAL2	Rummagene Transcription Factor Associations 2026	1.0	null
A549_WP1066_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143032
A549_Tacedinaline_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159387
GSE136622_7_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10990851__F9	PFOCR Pathway Figure Associations 2024	1.0	null
K562_BMS-536924_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0267766
K562_Pelitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0224502
A549_Lenalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224213
A549_Aurora A Inhibitor I_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180274
PMC6198132__F3	PFOCR Pathway Figure Associations 2024	1.0	null
MCF7_Capecitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149659
A549_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0341865
A549_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156729
PMC7727076__F6	PFOCR Pathway Figure Associations 2023	1.0	null
A549_Andarine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212833
A549_Bosutinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174841
FHOD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18338
PMC7053098__F5	PFOCR Pathway Figure Associations 2023	1.0	null
PMC3030969__F1	PFOCR Pathway Figure Associations 2023	1.0	null
A549_PCI-34051_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142066
A549_Tucidinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150419
MCF7_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0305534
A549_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0381008
PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Vandetanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0281201
RPS17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11632
MCF7_CYC116_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138126
MCF7_SB431542_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0422555
GSE220520_6_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_FLLL32_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0115765
EBF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14992
A549_Lenalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017071
K562_CYC116_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0333119
MCF7_Enzastaurin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015352
A549_PD98059_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151779
K562_AZD1480_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212737
A549_Iniparib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129816
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
K562_Curcumin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0337564
A549_Barasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160545
K562_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0311418
MCF7_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160641
PMC10079688-41467_2023_37633_MOESM7_ESM.xlsx-IP_JUN_in_WT_vs_sgJUN_cells-Supplementary_Data_4_List_of_interactors_of_JUN_identified_by_label-free_quantitative_proteomics_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3607232-mmc3.xlsx-a_RUNX1_SEM_MLLN_AF4C_H3K79Me-x_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
POM121	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31413
MCF7_Entacapone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014099
GSE237040_2_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Decitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140317
MCF7_Patupilone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116617
MCF7_Curcumin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0265939
GSE65617_2_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210383_0_v_1_trim71_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE113106_2_v_1_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Fluorouracil_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0280117
MCF7_Gandotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185613
GSE124048,GSE124067_1_v_0_irf6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0342913
A549_EED226_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139228