association	dataset	threshold value	standardized value
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE233183,GSE233187_2_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXC12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.515
GSE202434,GSE202438_4_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AMY2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00594081
PTPRH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00856176
GJD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00655476
NPY2R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00550977
PP 1	DeepCoverMOA Drug Mechanisms of Action	1.0	0.55
CRCGN014_HEPG2_3H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15694
GSE193999,GSE194000_4_v_0_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PDPK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00568971
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.571926
AFF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00859117
GSE110268_1_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NR2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.2831
TTR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00691435
t61-colon_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.6567
GSE119978,GSE180930_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PRMT8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00528621
GSE164521_0_v_1_nitric oxide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.253454
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE175787_13_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Seizures	DisGeNET Gene-Phenotype Associations	1.0	null
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
AICDA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00639713
GSE168797_1_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
SBK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00509561
GSE149903_4_v_1_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SCN4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00508748
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0912
PMC11511846-42003_2024_7078_MOESM3_ESM.xlsx-ST18-Unnamed_19_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K54637865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37438
Zotarolimus	DeepCoverMOA Drug Mechanisms of Action	1.0	0.51
F12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00519481
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126777_3_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ARCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02105
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Estimated glomerular filtration rate	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.739794
CRCGN015_MCF10A.TP53.M_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.339
GINS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00496205
BRD-K43473008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62653
GSE200502_2_v_1_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ADP binding	GO Molecular Function Annotations 2025	1.0	null
clocortolone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89742
MPL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00660984
GSE249146_2_v_3_dusp6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_10_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205163,GSE205164_3_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
BTN3A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00587881
BRD-K19852577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24372
GSE223540_0_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182835,GSE182836_0_v_1_siah2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203308_4_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162739_6_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K45916030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43067
AB-21-VE32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.819985
naltrindole-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.5157
GSE229973_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BLVRA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00410267
PCDHB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15805
HCLS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0068105
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S2-Table_S2_Full_result_of_MR_estimates_for_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
IRF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5305
Integument	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.834
Microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.114
Tonsil	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC10534007-Table_2.xlsx-S5_unique_up_MSC_B-721_elements_included_exclusively_in_BFTC905_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Slurred Speech	DisGeNET Gene-Phenotype Associations	1.0	null
TRAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00539733
GSE60217_1_v_2_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NSD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0114113
AZ20	DeepCoverMOA Drug Mechanisms of Action	1.0	1.58
BRD-K76543697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68479
IGSF8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00720249
GSE212330_1_v_0_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
delavirdine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25391
adenyl ribonucleotide binding	GO Molecular Function Annotations 2025	1.0	null
XA-40-AD40_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255824
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN011_HEPG2_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9012
PMC10117376-hmg-2022-ce-00467_r1-sollis-supptables_ddac311.xlsx-TS10_NDD_proteins_in_TBR1_inte-Table_S10_ID_and_ASD-related_proteins_in_the_TBR1_interactome_TBR1	Rummagene Transcription Factor Associations 2026	1.0	null
10995_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.62145
MYBL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2174
Spastic Ataxia	DisGeNET Gene-Disease Associations	1.0	null
NELL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00736833
CZC-25146	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
BRD-K08311368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61104
BRD-K10148216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26704
BRD-K11844807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21074
CRCGN014_HEPG2_24H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.8081
FAM156B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.91651
BRD-K05057860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83777
ZC3H12A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00564082
GR79236	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
NKX6-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1426
GYPB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0125477
GSE104022_3_v_4_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Left ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.014
MRE11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00526246
SMOX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0105886
SNX17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00430774
Glomerular Filtration Rate	DisGeNET Gene-Phenotype Associations	1.0	null
VMRCRCW_KIDNEY	CCLE Cell Line Proteomics	1.0	16.7264
Cerebellar cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.494
GSE234340_9_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11979751-table_s2_markers_elad055.xlsx-Melanoma_GSEA_state_markers-AP2_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
Leigh Disease	DisGeNET Gene-Disease Associations	1.0	null
GSE81193_3_v_5_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:N23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0789
YC-45-JD42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200718
BRD-K04877446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33016
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.605246
SGCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91598
BMP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00665556
GSE169356_2_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NADH dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.087
CRCGN016_MCF10A.TP53.M_24H:K19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67704
PMC6300607-41467_2018_7620_MOESM9_ESM.xlsx-common_BRD4-S_KO_MLL-AF9_loci-Unnamed_12_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2071
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.709873
XCR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00519086
Gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K14567490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21572
6889_PSPH_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.530773
ITGB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00742147
GSE77108_4_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE217363_0_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE101239_5_v_0_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
KCNJ14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00635215
Congenital disorder of glycosylation type IIi	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.394
GSTA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00732257
REG4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00475464
GSE137914_0_v_5_tet3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EREG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00484357
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-9_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE62843,GSE64370_4_v_1_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE208254_3_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193351_1_v_2_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dentatorubral-pallidoluysian atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.729
RNF24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00696036
BRD-K25200031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1743
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.019
Neutrophil Count (Procedure)	DisGeNET Gene-Phenotype Associations	1.0	null
GSE70499_3_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Proteinuria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.167
BRD-K49375456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16916
GSE150895,GSE150896_0_v_1_kif15_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IFNA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0104616
Photosensitive epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
GM2 gangliosidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.078
ZNF484	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18844
ubiquinone metabolic process	GO Biological Process Annotations 2025	1.0	null
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Primary coenzyme Q10 deficiency 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.169
EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.7037
BRD-K90519599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03934
496100453_HIP_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.67647
GSE129186,GSE129223_0_v_1_aicda_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:L15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0499
CEACAM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00557908
BRD-A89038047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65241
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-GM12878_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
496100347_PCx_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.17746
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.36524
BRD-K85767870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.76422
GSE206400_1_v_0_nusinersen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Thymus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.703
GSE236502_1_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K33805386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06904
ME-31-RM40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227324
AB-74-VK99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211986
ABI3BP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00775596
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.91213
GSE202434,GSE202438_10_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Movement disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.134
CRCGN011_HEPG2_24H:O22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1082
FD-15-HD09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211968
TRAF4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00702017
SMTNL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00708303
SUV39H2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0100058
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.306556
Spautin-1	DeepCoverMOA Drug Mechanisms of Action	1.0	0.37
MAP3K4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00869721
HPRT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00471108
GJC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0101472
CRCGN011_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.338
GSE172458_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CBX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00510316
ADP binding	GO Molecular Function Annotations 2023	1.0	null
PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_15_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149035_7_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE101527_3_v_2_smad4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K99482176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39577
cefmetazole	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20287
AE-37-MC27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.465953
X-linked monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.258
GPR141	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00852463
GSE92364_1_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CTSS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00615508
Vertebrate muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE173262_2_v_0_ash1l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152441,GSE152442_0_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00766334
EIF2AK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00843723
BRD-K10133810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0089
GSE221955_3_v_2_igfbp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE167324_2_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GAD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0139433
GSE221327_1_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K72700187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27356
CRCGN014_HEPG2_3H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.354
CLINDAMYCIN-PO4	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39627
Electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.618
MAP4K3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00504998
SYNM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00854866
Filtration diaphragm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.071
PDE4B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0048988
Inner ear disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.827
CRCGN015_MCF10A.TP53.M_24H:I23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9597
HRAS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00561908
BRD-K23051691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41593
Granulocyte Count	DisGeNET Gene-Phenotype Associations	1.0	null
CRCGN015_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1528
CRCGN017_MCF10A.WT.HP_24H:F10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9213
BRD-K71424167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.217
KPT-330	DeepCoverMOA Drug Mechanisms of Action	1.0	1.15
KMT2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.010649
GSE227891_5_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77795_2_v_1_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Progressive myoclonus epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.382
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.784386
496100412_FWM_possible Alzheimer's disease_TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.0951
TYMP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0057239
Mitochondrial matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.112
BRD-K18094884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46346
BRD-K94480039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99309
Mitochondrial metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.661
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.488701
JUN::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9113
phospholipid-translocating ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.617
e2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.879
Ataxia	DisGeNET Gene-Phenotype Associations	1.0	null
3-methylglutaconic aciduria type 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
DUOX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00716844
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
NOX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00697022
GSE48812_4_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
SETD1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00490419
NKX2-6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0103169
BRD-K13927197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24476
HOXD11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2
G6PC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00625208
GSE154767_4_v_3_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Visual cortex disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.261
GSE234340_1_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE116492,GSE116495_3_v_2_stag2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE155031_5_v_0_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04914
GSE223008_0_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE167324_1_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Organelle inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.447
ADCY3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00950779
Tivozanib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.53
CAL120	DepMap CRISPR Gene Dependency	1.0	8.62457
BRD-K47804666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50406
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
iron-sulfur cluster assembly complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.576
RBM6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0043867
SLC25A37	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00666246
GSE205163,GSE205164_5_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05273
GSE198165,GSE198166_6_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE196699_4_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.195
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.776312
SERPINB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520588
BRD-K00020149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45813
BRD-K54814515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00314
Mitochondrial respirasome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.38
CAL-101	DeepCoverMOA Drug Mechanisms of Action	1.0	0.32
CRCGN016_MCF10A.TP53.M_24H:C16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4434
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K64704925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0646
CCR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00810015
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF410	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.654
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241803
GSE229973_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GPR82	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0069151
KLHL5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00611497
GSE48812_2_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:I23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.92057
GSE160373_6_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_10_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DA-27-BW40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.556805
BRD-K71210410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23564
CCN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00663358
CRCGN017_MCF10A.WT.HP_24H:I05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03042
GSE128634,GSE128636_4_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OB-06-WW76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.712585
ZBED2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00558341
Dihydrolipoyl dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.043
RAF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.011727
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-2_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158458_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:G08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4994
BRD-K07895476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10642
PDE5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00904953
PMC9288051-13046_2022_2428_MOESM4_ESM.xlsx-Super_enhancers_in_AML3-CLOSEST_GENE_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
HNMT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00642183
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K10196668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6569
GSE112860_9_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Proplastid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.727
CRCGN015_HEPG2_48H:A24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15632
GSE88819_0_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF214	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9999
risedronate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.52363
Hydathode	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.51
GSE205070_1_v_4_mertk_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1395	DepMap CRISPR Gene Dependency	1.0	3.74296
Skeletal system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE207914_3_v_6_nudt7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GRIA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00708857
SLC25A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0069014
NSDHL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00370209
Integral component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.08
AE-52-NW93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232283
CRCGN016_MCF10A.TP53.M_24H:J02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12654
BRD-K67024719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40353
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.07475
GABPB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00518796
T-bar	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.538
GSE142019,GSE142021_1_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226115,GSE226116_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K05208441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48528
mitochondria-associated endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.365
CDK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0053781
AA-62-OC45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.484184
Glial cytoplasmic inclusion	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.768
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Gedatolisib	DeepCoverMOA Drug Mechanisms of Action	1.0	1.35
GSE190316,GSE190324_6_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Central Hypotonia	DisGeNET Gene-Phenotype Associations	1.0	null
KYAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0113212
GSE158834_1_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5303304-13073_2017_407_MOESM5_ESM.xlsx-mycn-sy5y-se_single_24DMSO_vs_4-Table_S4_Genes_differentially_expressed_by_48h_Dox_MYCN_overexpression_treatment_DE_comparison_with_SY5Y-MYCN_control_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7469
RFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23281
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267601
BRD-K93260425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26571
GSE159084_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE198165,GSE198166_7_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE173873_10_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Succinate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.52
BRD-K90264208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16076
BRD-K05501176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25629
Sensorineural hearing loss	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.85
BRD-K68853384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09309
BRD-K52094743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8381
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.552666
GSE178292_0_v_3_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE166317_3_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NQO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00841244
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC9288051-13046_2022_2428_MOESM4_ESM.xlsx-Super_enhancers_in_AML2-CLOSEST_GENE_RUNX3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE189653,GSE203344_4_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE136238_1_v_2_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrial crista	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.189
LD-69-ZV56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.941948
ubiquinone biosynthetic process	GO Biological Process Annotations 2023	1.0	null
GSE219195_1_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K22974051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01732
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.325832
CRCGN010_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8697
BRD-K43205312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02388
POFUT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00673307
NIFK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07389
BRD-K94742710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02548
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6089552-oncotarget-09-31018-s004.xlsx-compound_targets_chip_rnaseq-Chip-seq_derived_EWS-FLI1_targets_Bilke_et_al_2013_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
Cerebellar Purkinje cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.583
KMT2E	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00463031
GSE120595_0_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K05831461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1488
GSE133070_3_v_1_prss1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.282477
TNFRSF4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00581098
ZNRD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00480535
BRD-K11259871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04154
CRCGN016_MCF10A.TP53.M_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.27295
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.364145
HHLA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00672214
ubiquinone biosynthetic process	GO Biological Process Annotations 2025	1.0	null
Cerebellar disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.706
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
Excretory gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE146612_2_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226939
IL6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00503589
SLVL	DepMap CRISPR Gene Dependency	1.0	7.07338
GSE147366_1_v_2_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K06181307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51838
GSE130246_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9380317-13045_2022_1327_MOESM3_ESM.xlsx-Table_S4-Table_S4_Top_500_differentially_modified_gene_bodies_between_AA_and_EA_patients_with_MM_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
SYT11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00902947
Cranial nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.875
CRCGN015_MCF10A_48H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.72145
GSE202434,GSE202438_8_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K03205303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30085
Optic nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.804
GSE135514_2_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FDXR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00478321
BRD-K72866723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40276
Mitochondrial metabolism disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
CRCGN011_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.1857
KB-78-BE93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.502943
ATXN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0102504
Biceps	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.681
GSE202434,GSE202438_3_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0141
CRCGN017_MCF10A.TP53.M_24H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1425
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.460314
CSF2RB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00804157
Primary coenzyme Q10 deficiency 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.126
BRD-K87878529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84919
PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_14_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171292_6_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Motor neuron disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.197
TP53BP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00560279
AF-67-LZ82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.295914
DPH5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00777963
Inherited Neuropathies	DisGeNET Gene-Disease Associations	1.0	null
RGL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00693545
CRCGN015_MCF10A.TP53.M_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09516
Xanthomatosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.556
GSE202434,GSE202438_10_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
REN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00874188
SNAPC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00649462
GSE118794_0_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BB-87-SF89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.382965
CIBAR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00701836
DOK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00550162
ZNF211	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6574
BRD-K65445351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0345
GSE200502_0_v_1_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DUX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5663
EDIL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00509243
BRD-K17285268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16659
CRCGN017_MCF10A.WT.HP_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.512
GSE124410_6_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_5_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AKR1C4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00994549
PR interval	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.35229
GSE147366_1_v_4_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FE-64-KC49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.5798
Mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.344
GSE89569_3_v_0_nr0b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152441,GSE152442_0_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_9_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_24hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202434,GSE202438_13_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
IDH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00807809
BRD-K96978561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97185
GSE98831_1_v_0_brca1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
GSE219274,GSE219276_3_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K38970027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00884
BRD-K91341416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35746
GSE180951_1_v_3_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
PMC10361959-41419_2023_5985_MOESM1_ESM.pdf-1619-ENSG00000083838_ZNF446	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K80176886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53912
TIM22 mitochondrial import inner membrane insertion complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.526
1717_CNOT2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.714965
GSE122101,GSE122103_3_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_4_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE125014_6_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE220520_3_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.687
VIPAS39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30656
MTAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00566831
Hypertrophic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.733
Focal segmental glomerulosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.727
DCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35719
PTPN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00606642
BRD-K04559718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80928
CRCGN017_MCF10A.WT.HP_24H:J19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20695
Respiratory chain complex I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.187
CRCGN017_MCF10A.WT.HP_24H:G19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06895
HEATR9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00628669
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
CRCGN015_MCF10A.WT.HP_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1319
GSE139911_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CLCN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00595903
GSE161170,GSE161268_0_v_2_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K36882679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00569
SLC23A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0119809
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.432917
K562_Pirarubicin_1µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149705
GSE186810,GSE186813_7_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00761
CRCGN015_MCF10A.WT.HP_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.20234
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.351439
Idasanutlin	DeepCoverMOA Drug Mechanisms of Action	1.0	1.22
Exotropia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
PMC11993713-41598_2025_96655_MOESM1_ESM.xlsx-S10-Table_S10_MR_results_of_the_discovery_blood_cis-eQTLs_and_Sepsis_outcomes_in_IVW_or_Wald_ratio_methods_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.32542
GSE144838_4_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Progressive Cerebellar Ataxia	DisGeNET Gene-Disease Associations	1.0	null
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239
Respiratory chain complex II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.539
MDAMB453	DepMap CRISPR Gene Dependency	1.0	7.79137
GSE233679_14_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TGFB1I1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00559439
GSE240030,GSE252532_0_v_2_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OGA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00801064
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4334
EA-40-KQ08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210665
BRD-K76899562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28555
Anxiety	DisGeNET Gene-Disease Associations	1.0	null
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9921
CDC6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00565081
GSE122215,GSE122217_0_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133516_0_v_6_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RAI2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00880082
BE-31-XV38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.566037
NDUFC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0093043
BRD-K68364310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62241
GSE157233_1_v_4_a1cf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE221327_10_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE239578_2_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KCNN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00603536
SLC37A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0081498
GSE202434,GSE202438_3_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195503_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6484770-41388_2018_602_MOESM5_ESM.xlsx-up_P53_vs_con-Unnamed_1_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
P2RY12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00889046
GSE208254_3_v_1_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CYP24A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00636038
Waist circumference adjusted for body mass index	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.23979
BRD-K82508779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94408
IL4I1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00657986
GSE202434,GSE202438_6_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:L24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.36641
Pictilisib	DeepCoverMOA Drug Mechanisms of Action	1.0	1.36
CRCGN015_MCF10A.WT.HP_24H:I16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44853
Uterus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE200430_1_v_0_sema3d_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K60272064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32228
UBASH3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00595515
GSE149903_0_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MPZ	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00491953
EPOR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00919193
Increased Serum Lactate	DisGeNET Gene-Phenotype Associations	1.0	null
GSE231829_0_v_1_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CNOT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.006
BRD-K47034148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5387
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336664
GSE125219,GSE125221_3_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
KA-29-AB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.421468
CRCGN015_MCF10A.WT.HP_24H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2702
GSE146074_9_v_11_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520247
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.4797
JHU029	DepMap CRISPR Gene Dependency	1.0	2.0578
GSE231799_3_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.921
BRD-K23997756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06101
GSE162276_2_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE198165,GSE198166_0_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KE-73-XV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.716097
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN011_HEPG2_24H:I04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4187
BRD-K88070373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39199
TMEM81	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00808688
CRCGN011_HEPG2_24H:H06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31635
ALK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00566923
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-encode-consensu_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE129241_4_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DPEP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00505749
EDNRA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00663657
TCN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00752876
GSE160817_5_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Plant crown	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.038
PSAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00657787
Heterotetrameric decaprenyl diphosphate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.322
GSE185944_2_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE115395_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
pralidoxim	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28037
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.902
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_9_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.225
GSE193258,GSE193259_9_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259242
DVL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532804
SRPK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0105142
GSE235066_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210101,GSE210114_11_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.370709
PYCR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0146847
CRCGN011_HEPG2_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.38115
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.605499
GSE193258,GSE193259_5_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hindbrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
Granulocyte count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.2
TPH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00514648
GSE142210_11_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135352_2_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLC35C1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00557156
BRD-K18600476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69143
PMC7606598-NIHMS1624889-supplement-1624889_Supp_Tab1-10.xlsx-S8_MR-JTI-geneid_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
KMT5C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00623587
Eosinophil Count Procedure	DisGeNET Gene-Phenotype Associations	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02537
GLTP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00995679
Skin fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.7
HCC70	DepMap CRISPR Gene Dependency	1.0	3.4652
GSE137818_5_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nephrotic syndrome type 9	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.166
TUBD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0134751
BRD-K74311661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24332
GSE48812_3_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152055_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EXTL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0106571
BRD-K26591929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16638
BRD-K81139344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23597
GSE175787_4_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118794_2_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE235066_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF213	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04275
SMAD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00635043
K562_Busulfan_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144515
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
RHOXF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.7995
INKA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00626909
RPL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46137
IL13RA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00633772
EIF3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49784
TSPAN32	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00613838
GSE128730_0_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.74065
GSE100316_7_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Spi1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	380.648
GSE118077_4_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S3.xlsx-Day_4_GATA6-dependent_genes-GATA6-dependent_mRNA_expression_Day_4_Definitive_Endoderm_FDR_0_05_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
RDH13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00585579
GSE62843,GSE64371_4_v_0_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE157050,GSE157051_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CH-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.501
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-6_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112860_0_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239578_5_v_4_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SLC38A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00713048
HINT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00590526
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.613932
GSE232631_4_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:O23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1951
BRD-K62795540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38823
GSE168596_1_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Status epilepticus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.603
Kidney failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.437
BRD-K66555134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64126
Right atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.671
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.764
AKR1C2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0108365
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Intrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.641
C1QBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00645461
GSE209601_0_v_1_mef2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.190426
Muscle	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ataxia	MGI Mouse Phenotype Associations 2023	1.0	null
GSE134214_0_v_1_ell2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23257
GSE185922_1_v_2_riok2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEP3_DN_AA_DN-AA_DN_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
IFNA10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00591773
BE-27-RQ61_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.584129
TNFSF9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00768548
PRDX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00846921
BRD-K07409609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02689
GSE217441,GSE217443_1_v_0_ivosidenib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-10_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
EFNA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00594713
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
EVI2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00677806
ATP5F1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00507445
GSE164874_5_v_14_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE245778_1_v_0_runx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TMPRSS9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00621359
PRKDC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54676
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.1766
3-methylglutaconic aciduria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.626
BRD-K96615474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17515
CB-32-EI69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.335434
ZHX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00745806
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.74873
BRD-K87264606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73271
GE-98-ZI68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20523
PPP4R3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00600717
BRD-K29898553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42832
SIPA1L3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00671767
MARS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0076355
GSE198165,GSE198166_8_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DDX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0101244
BRD-K18984088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02504
GSE254649_2_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11609822-cd-24-0018_supplementary_table_s8_suppst8.xlsx-Visium_Clusters_DEGs_LR_test_LF-gene_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K31059159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2087
GSE227891_2_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Talipes	DisGeNET Gene-Disease Associations	1.0	null
DPAGT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00883622
IKBIP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00627421
Episodic ataxia type 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.236
CRCGN014_HEPG2_3H:E14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0794
PMC8160578-JCB_202009147_TableS4.xlsx-E2F1_targets-Genes_n_1867_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE165122_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K05561348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18133
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.486947
MPI-0479605-HCL	DeepCoverMOA Drug Mechanisms of Action	1.0	0.39
Cerebellar ataxia type 47	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.497
TNFSF8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00723666
Axonal neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.711
ZNF18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09477
PUS10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0085668
GSE196318_0_v_1_xpo4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CA11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0142896
GSE175787_5_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2574
IE-38-FB31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.384939
MAPK15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00621551
GSE213588_10_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270096
GRAMD2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00762232
CRCGN017_MCF10A.WT.HP_24H:B07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01495
Spinocerebellar ataxia type 13	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.491
GPATCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62383
SLC1A7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00553569
protein phosphorylation	GO Biological Process Annotations 2023	1.0	null
GSE148692,GSE148695_7_v_6_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_15_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FASLG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52232
GSE159148_0_v_1_sdc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151612_0_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CCND1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0144572
Six4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.4917
ATXN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30879
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.921601
GSE157296,GSE157298_4_v_5_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:G09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20155
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.312235
SOWAHC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0131848
HIF1AN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.012224
CF-24-KQ98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233285
BRD-K22564762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00564
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K41731186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15002
PGR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00747946
GSE163809_1_v_2_sdhaf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CLC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00584265
CD-13-QZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235026
X-linked recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.28
GSE133213_9_v_13_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RASAL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00433822
NECTIN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00586622
HRH3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00594242
Migraine	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.704
GMEB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65509
NA-30-HS87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271045
MCF7_Tubastatin A HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149042
GSE100732,GSE100733_0_v_1_lrpprc_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brugada syndrome 9	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.094
SARM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00778317
Regio parietalis capitis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.636
TRAK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78044
Metencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
AZD8055	DeepCoverMOA Drug Mechanisms of Action	1.0	1.6
BMS 754807	DeepCoverMOA Drug Mechanisms of Action	1.0	0.5
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-63-DM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273162
Renal glomerular capsule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.586
Retinitis pigmentosa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.555
m-AAA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.044
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.751047
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
TSC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00830433
7393_RNF4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.610513
Exocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Genetic disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
BRD-K80782159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74502
Primary coenzyme Q10 deficiency 9	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.662
PDSS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02668
GSE226115,GSE226116_1_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE86507,GSE86509_7_v_9_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
glycerol-3-phosphate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.153
BRD-K87748094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00049
BRD-K46790201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21532
GSE241875_1_v_0_huwe1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2539
GSE168807_6_v_7_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160001,GSE160670_3_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_10_v_9_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K47906308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58709
ULK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00765492
TCF12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0103401
GSE134191_6_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K59960811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31686
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.9149
COLEC11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00531493
FOXO1::ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.245
BRD-K63754039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50967
GSE198165,GSE198166_5_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.557
X-linked sideroblastic anemia with ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.279
USP18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00671608
CPT1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00410021
BRD-K14723547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53493
CRCGN017_MCF10A.WT.HP_24H:E18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.49455
YARS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0071731
MLXIPL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4203
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.947985
CRCGN017_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4233
GSE243683_0_v_1_s100a16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
APOH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00510825
GSE135514_2_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9469
PMC8405683-41419_2021_4120_MOESM2_ESM.xlsx-Sheet1-Table_S2_MYCN-responsive_gene_list_1_5_fold_p_0_05_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30214445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19205
PMAIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02588
GSE248045,GSE248046_0_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169691_1_v_2_saha_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE227592_13_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K27028848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27721
KDM1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0076084
CRCGN011_HEPG2_24H:K21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.03285
CRCGN015_MCF10A.TP53.M_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.99845
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K63468420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53585
CRCGN015_MCF10A_48H:F04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.16655
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DARS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00834566
Duvelisib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.64
GSE163862_2_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:A06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1604
quinone biosynthetic process	GO Biological Process Annotations 2025	1.0	null
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_up_VENN-697_elements_included_exclusively_in_HIF1_genes_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GSK2334470	DeepCoverMOA Drug Mechanisms of Action	1.0	0.88
NIN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00522087
MEP1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00407961
GSE165122_0_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
t56-vastus-lateralis_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.46335
NSD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00689445
RDH14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00697588
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE231720,GSE231724_2_v_0_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HLA-DRB5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0111911
GSE48812_7_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169356_2_v_5_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K92884779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0427
GSE211425_1_v_0_mettl3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12559107-12035_2025_5221_MOESM1_ESM.xlsx-Supplment_Tab_3-Supplement_Tab_3_The_result_of_MR_analysis_for_SCZ_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Generalized dystonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.273
BRD-K41504921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.71603
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE70499_5_v_6_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE154577_6_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K06248125	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62546
CRCGN011_HEPG2_24H:A10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42375
GLYAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00802022
Axon cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.584
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-MYC_UP_V1_UP-Gene_name_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K84401063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45908
GSE193351_1_v_0_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE152432_9_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE81803,GSE81912_4_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE65617_2_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DARS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00845052
BRD-K43298189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11697
GSE225218_0_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ATP11B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00470445
IDO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0063864
KCNB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00572896
PMC11437185-41467_2024_50986_MOESM4_ESM.xlsx-MECOM-IP-MS-Gene_names_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
KAT2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00483022
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K64135153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56856
PMC10376127__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Joubert syndrome	ClinVar Gene-Phenotype Associations 2025	1.0	null
Variable age at onset electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.375
GSE166536_3_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TTC642	DepMap CRISPR Gene Dependency	1.0	3.11481
GSE254649_2_v_0_cstf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HEXA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.011045
GSE112763,GSE112767_4_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mitochondrial DNA depletion syndrome 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.269
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.13612
CRCGN011_HEPG2_24H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11325
ERP27	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00843755
GSE157296,GSE157298_4_v_3_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SUDHL4	DepMap CRISPR Gene Dependency	1.0	6.4493
AURKA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00586103
AD-09-MD49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.3052
GSE189653,GSE203344_5_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE120612_4_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
FDX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00530125
BRD-K74896637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46666
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.582921
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7898
BRD-K32163723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60713
PMC10117376-hmg-2022-ce-00467_r1-sollis-supptables_ddac311.xlsx-TS1_AP-MS_results-Table_S1_TBR1-interaction_candidates_identified_in_two_AP-MS_experiments_TBR1	Rummagene Transcription Factor Associations 2026	1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251186
PMC7529585-41388_2020_1433_MOESM3_ESM.xlsx-1_Targets_genes-P53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S1-Table_S1_Instrumental_variables_used_in_MR_analysis_of_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
SLC26A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0185291
Chronic progressive external ophthalmoplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.105
BRD-K18645499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54268
GSE220097_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193258,GSE193259_5_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Variable Expressivity	DisGeNET Gene-Phenotype Associations	1.0	null
MAP2K1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0054176
BRD-K86237035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.178
SLC11A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00689567
GSE158458_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Biceps brachii	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.631
BRD-K05760078	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95243
BRD-K90819764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19828
GSE148066,GSE157787_3_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSPT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00722634
HSP90AB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00436057
GSE197562_2_v_3_nox4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.76
PMC7441006-41388_2020_1389_MOESM2_ESM.xlsx-Supplementary_Table_1-Prostate-Specific_MYC_Overexpression_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
Plastid nucleoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.782
CENPC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40767
D542MG	DepMap CRISPR Gene Dependency	1.0	3.0467
MCM6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00424003
GSE216757_0_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:F24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.64998
MAPK8IP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00463993
BRD-K06974027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43521
GSE230329_0_v_3_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE214931_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K34009761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05937
adenyl ribonucleotide binding	GO Molecular Function Annotations 2023	1.0	null
ARPC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00774652
X-linked hereditary ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.161
AADACL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00677043
ACTL6A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00433065
HA-22-CY42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267111
BRD-K40485332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22066
GSE148066,GSE157787_8_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K76803075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89425
PMC10592471-NIHMS1912771-supplement-2.xlsx-NR2F1-Ind-Downregulated_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
TAE 226	DeepCoverMOA Drug Mechanisms of Action	1.0	1.39
BRD-K85567359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15365
INTS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00818392
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:D23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46122
SLC2A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564673
BRD-K12202458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65905
GSE169356_2_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-US-ID_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN011_HEPG2_24H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5001
Scoliosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.207
Mitochondrial proton-transporting ATP synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.673
CFLAR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00441313
PHOX2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.2321
PPIB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0121209
CRCGN011_HEPG2_24H:B09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.11625
PMC9288051-13046_2022_2428_MOESM4_ESM.xlsx-Super_enhancers_in_AML3-OVERLAP_GENES_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
meglumine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89069
nucleus-vacuole junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.62
WDR6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70483
Familial hemiplegic migraine	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.133
IC-05-AW29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.425838
phosphate-containing compound metabolic process	GO Biological Process Annotations 2025	1.0	null
Ocular motility disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.795
Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.975
SR-1001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77623
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim29_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
KEL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00620395
GSE119498_2_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GPR143	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00929341
GSE203584_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K26612358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49021
BRD-K76960042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28611
FF-28-ES17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.31836
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
End stage renal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
SH2D1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00748872
PMC9314667-Table_1.xlsx-Regulons-TFAP2B_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
SIX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6035
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198254_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NFAT5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00599612
MYBPC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00759605
BRD-K96288607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10829
ATP6V1C1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00755905
NDUFS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00459039
Peroxisomal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.146
GSE166169_2_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114232_10_v_11_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim22_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ASS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00390469
MST1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26469
NFATC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00466297
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_downregulated_genes-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10864182-41588_2023_1596_MOESM4_ESM.xlsx-ST12_Significant_Genes_combine-Unnamed_1_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
ABT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69686
GSE131680_1_v_0_macroh2a1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Metabolism of cofactors	Reactome Pathways 2024	1.0	null
Decaprenyl diphosphate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.699
CRCGN015_MCF10A.TP53.M_24H:N05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04015
Coenzyme Q10 deficiency disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.352
GSE226397_0_v_1_cystine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K10571481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03269
GSE205163,GSE205164_5_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-5_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
Outer mitochondrial membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.254
Mitochondrial envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.328
GSE60217_1_v_7_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8567280-EMBR-22-e53014-s007.xlsx-Sheet1-Nearest_genes_to_BAZ2A-bound_C2-Enhancers_BAZ2A	Rummagene Transcription Factor Associations 2026	1.0	null
BACE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00633503
PMC7806814-41598_2020_80145_MOESM3_ESM.xlsx-CombinedResults_TreatbySexMainE-Supplementary_Table_S2_Genes_with_significant_FDR_0_05_sex_by_LPS_treatment_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
P4HA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0105084
MMP19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00866787
PMC11067031-pnas.2317690121.sd03.xlsx-gene_list_-_2022-04-13T081711_1-Differentially_expressed_genes_between_PML_RARA_GFP_vs_Empty_vector_GFP_mouse_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.42699
MFSD10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00405629
AB-30-CR11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.305507
Oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN015_MCF10A.WT.HP_24H:B24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01573
PMC7488531-13287_2020_1914_MOESM10_ESM.xlsx-HNF4A_regulated_DEGs_750-Unnamed_1_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.909
GSE199092_3_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.478886
chr1_226974823_G_T_b38	GTEx eQTL 2025	1.0	1.09766
Pt-K1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.888
CRCGN011_HEPG2_24H:J06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.70455
IKZF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00589433
PMC7710892__F3	PFOCR Pathway Figure Associations 2024	1.0	null
GSE203308_15_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:P15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1312
MBNL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00418286
GSE228413_2_v_1_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_6_MRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
Small intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HOXC9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2684
GSE201309_4_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
p1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.78
BRD-K75900952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.3466
CRCGN017_MCF10A.TP53.M_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25917
TNP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39943
BRD-K70158474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22939
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.397166
GSE154767_1_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Neurodevelopmental Delay	DisGeNET Gene-Phenotype Associations	1.0	null
GBA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5903
BRD-K05975035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01502
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4404
GSE144231_4_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
tylosin-tartrate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.79995
PMC12903644-12967_2025_7606_MOESM4_ESM.xlsx-HALLMARK_P53_PATHWAY-SYMBOL_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE125862_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
UPB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00467927
SLC16A14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00616045
Mathematical Ability	DisGeNET Gene-Phenotype Associations	1.0	null
CRCGN011_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62495
CRCGN016_MCF10A.TP53.M_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.6226
GSE125014_6_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE198165,GSE198166_9_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE104508_0_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE125014_1_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PHYKPL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00713827
VWA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00505891
Mitochondrial permeability transition pore complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.354
GSE148692,GSE148695_7_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ARF6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00717614
USP28	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0076956
GSE93124_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLC6A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0071851
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE229671,GSE229673_0_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Glutamate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.547
BRD-K17910820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32034
GSE116810_2_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.375
Abnormal Behavior	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K09523238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23635
CRCGN009_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.40445
GSE119978,GSE180930_6_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DNM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00325934
Breast	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NDUFS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00639087
CRCGN016_MCF10A.TP53.M_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04424
GSE202434,GSE202438_2_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3807112-srep03041-s6.xls-GABPA-Gene_Symbol_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K64039518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41015
DESI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564158
t60-adrenal_male_1w	MoTrPAC Rat Endurance Exercise Training	1.0	1.38797
USF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0689
BRD-K83109105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06293
BRD-K92749855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03311
GSE205163,GSE205164_2_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.852188
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.948384
MYD88	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0103146
BRD-K41561756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34357
CTSB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0067482
BRD-K99529078	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03584
BRD-K49577636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63684
Intrinsic component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.956
CRCGN015_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.8754
SLAIN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00553273
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.18
Mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.471
Fibre tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.001
GSE149760_3_v_5_elof1_human	RummaGEO Gene Perturbation Signatures	1.0	null
FSCN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00690677
GSE198165,GSE198166_5_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4335056-pone.0116726.s005.xlsx-X-ChIP_NOT_TX100_QE-GENE_Official_symbol_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.329478
Glutamate synthase complex (NADPH)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.629
GSE184210_0_v_3_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K03791970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75419
GSE233566_1_v_2_braf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OB-06-WW76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258407
SCARA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00726185
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BB-79-AG41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.33663
PMC10714175-mmc2.xlsx-KD_Gene_list-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE205730,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Biotinidase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
GSE134191_3_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Left atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.834
BRD-K46715415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35461
GSE123943_4_v_3_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4944136-srep28995-s2.xls-DUXA-gene_DUXA	Rummagene Transcription Factor Associations 2026	1.0	null
Tremor	DisGeNET Gene-Phenotype Associations	1.0	null
PTTG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30054
HSPA1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00799415
SMARCAL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00495507
p2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.21
LD-69-ZV56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.487946
Pontocerebellar hypoplasia type 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
Integral component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.079
Neurodegeneration with brain iron accumulation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
GSE207787_1_v_4_pdha1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Epididymis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PDE6B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0108087
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0966
GSE114232_8_v_11_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Renal tubular transport disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.242
Multiple system atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.828
GSE111881_0_v_1_znf768_human	RummaGEO Gene Perturbation Signatures	1.0	null
Mouth	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE88819_0_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE214596,GSE214598_1_v_4_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Tozasertib_10µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160745
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	1.0	null
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.1399
SCN5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00540637
metaraminol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40954
Merrf Syndrome	DisGeNET Gene-Disease Associations	1.0	null
CRCGN014_HEPG2_3H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30627
BRD-K08799663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30766
Organellar small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.763
BRD-K20644549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07938
Congenital nervous system abnormality	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
CREB3L4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00801205
GSE56235_1_v_0_prdm11_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7906903-41366_2020_716_MOESM2_ESM.xlsx-DEG_HMGA2-fusion-Gene_Symbol_HMGA2	Rummagene Transcription Factor Associations 2026	1.0	null
TNFRSF13B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00659898
BRD-K99789346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.65563
GSE193402_0_v_3_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6742760-41467_2019_12079_MOESM10_ESM.xlsx-Data_S8-Supplementary_Data_8_Target_genes_of_FOXA1-bound_enhancers_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6172843-13059_2018_1523_MOESM6_ESM.xls-Sheet1-Table_S5_mRNAs_variation_abundance_1_5-fold_in_YBX1-knockdown_BGC-823_cells_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
GBR 12909	DeepCoverMOA Drug Mechanisms of Action	1.0	0.81
ATP5F1D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00618942
NANOG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00465592
BRD-K37637965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35352
CA9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00565088
STON2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00581196
GSE139016_3_v_2_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
GPX5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00811478
SMKR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00628323
BB-11-JI42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211257
H2AB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20906
TMEM158	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09072
ABAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0057837
GSE137144_2_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GCH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00494381
BRD-K47415214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.8383
cytochrome-c oxidase deficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.318
GSE143462_0_v_1_omipalisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE232786_1_v_0_otud1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_12_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7349
GSE200352_1_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-Aza_atRA_DE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
A2M	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.010278
GSE186483_2_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.335
TCN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00495494
CRCGN015_MCF10A.WT.HP_24H:P02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.52182
PMC12478325-12672_2025_3468_MOESM1_ESM.xlsx-Table_S9-Table_S9_Results_of_MR_analysis_between_druggable_genes_eQTLs_and_CrNEN_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
LD-39-FL02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.388043
CB-99-OG76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.521814
GZMA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00632137
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Vertebrate muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Mitochondrial ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.333
CRCGN011_HEPG2_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.71145
Cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.629
Neuromuscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.236
KCND1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00526297
GSE173873_10_v_13_stra8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K31778201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08159
GSE169697,GSE169725_1_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrial nucleoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.016
environmentally induced seizures	MGI Mouse Phenotype Associations 2023	1.0	null
CA-00-AR16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217563
BRD-K83645749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32299
GSE211955_1_v_0_jmjd4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K56224420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56714
DLG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00380788
OB-17-DQ74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285969
MCF7_Motesanib Diphosphate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125289
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Combined-MYB_Combined_sgRNA_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE197571_2_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE219195_1_v_3_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Autosomal dominant cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.104
CHD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46123
GSE202434,GSE202438_7_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90445
FD-59-TC81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.330848
GSTA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00680698
GSE125014_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K24246830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06105
HOXD10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6454
Gli1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.7704
DCST1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00709547
Gangliosidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
Ascl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.3657
PMC5577301-in-17-237-s001.xls-AR_downregulated_DEGs-Heart_GSE9377_GENE_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CYB5R3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0118233
RGL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00627459
CTSH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00370651
AZD7762	DeepCoverMOA Drug Mechanisms of Action	1.0	0.98
PMC12712253-12672_2025_4014_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_for_PC_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE145507_2_v_5_hopx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE176093_2_v_3_mineral oil_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE219274,GSE219276_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SERPINB5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00781889
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1055
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.927
TOMM5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00577673
abnormal enzyme/coenzyme level	MGI Mouse Phenotype Associations 2023	1.0	null
GANAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33429
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.815
AMPD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00965128
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.7677
hyperlipidemia	MGI Mouse Phenotype Associations 2023	1.0	null
Niemann-Pick disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
GSE143643,GSE143644_2_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE241701_4_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KLHL14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00690696
Sideroblastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.481
GSE233256_0_v_1_rbms1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TIMP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00742235
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0674
GSE143643,GSE143644_3_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3879
ISL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.4555
BRD-K67874412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15793
CA-68-KG29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.531547
CRCGN009_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.28439
BRD-K91490997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11642
RHEBP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00447294
Primary coenzyme Q10 deficiency 8	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.998
PRX-08066	DeepCoverMOA Drug Mechanisms of Action	1.0	0.37
Cardiofaciocutaneous syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.729
PMC5550424-41467_2017_212_MOESM4_ESM.xlsx-Hematlas-Genesets-NANOG_NANOG	Rummagene Transcription Factor Associations 2026	1.0	null
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260331
Muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CYP2R1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29977
Purkinje cell degeneration	MGI Mouse Phenotype Associations 2023	1.0	null
GSE223540_1_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.13086
CRCGN009_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41981
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_12hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
DTYMK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00357559
KCNK13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00924463
AC-36-TL21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.782943
N1E-115 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.845
BRD-K83436911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44081
GSE96991,GSE97117_3_v_0_il11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:D13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1406
Mitochondrial respiratory chain complex III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.968
GSE138938_1_v_2_foxp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11639743-mmc2.xlsx-LIN28B-gene_name_LIN28B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE144231_3_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Leigh disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.323
Ceritinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.62
YF-00-IN39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.572312
Collagen type IV trimer	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.553
GSE212772_0_v_1_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217776,GSE217829_4_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GFI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00558077
GSE215086_1_v_6_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110268_2_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5494
THRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.2076
JM1	DepMap CRISPR Gene Dependency	1.0	2.11701
GSE173262_6_v_0_ash1l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141778
BRD-K89232006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32138
GSE245134_2_v_3_atg5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Wes	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.998
Mitochondrial complex I deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.273
HPS4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00537249
BRD-K80443236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98167
GSE151612_0_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE229973_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLC5A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00599138
GSE156454_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210655_3_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226249_5_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9557
Sum neutrophil eosinophil counts	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.21549
AC-55-XA97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.344342
MAP1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00890342
HOXB13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00917511
Electromyogram Abnormal	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K31977946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38305
BRD-A63382799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12727
ATF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.5055
GSE119498_0_v_5_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE173232_2_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BB-77-QQ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.384668
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149264,GSE149267_4_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K41563239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17107
BTN2A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00478215
proton-transporting ATP synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.184
MDH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00714082
PMF1-BGLAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00588784
AM 630	DeepCoverMOA Drug Mechanisms of Action	1.0	0.46
TANK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00652584
GSTO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00620241
MGA::EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.6118
Brain stem	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
CHD7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00681735
KB-78-BE93_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251219
BRD-K49745983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.46514
Mitochondrial electron transfer flavoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.013
GSE226114,GSE226116_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8851354-Table_6.xlsx-STAT3-bound_genes_GM12878-Supplementary_Table_6_STAT3-bound_unique_genes_in_GM12878_cells_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
STAM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00485447
LPAR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00725725
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3325
BRD-K76691746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1087
GSE234340_12_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131565_1_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8714
Focal T2 Hypointense Basal Ganglia Lesion	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K61052964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40783
PMC10451954__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE223008_6_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ubiquinol biosynthesis	Reactome Pathways 2024	1.0	null
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.3963
DOCK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0097308
Brequinar	DeepCoverMOA Drug Mechanisms of Action	1.0	1.16
NR1D1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.769
CC-68-YZ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.32037
BRD-K95192796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5912
AD-18-XC14_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217924
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-Hela_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
Enzastaurin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.74
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.7944
GSE252857_1_v_0_prednisone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_10_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.09307
lomofungin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.75773
FHIP1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00493245
GSE196407_1_v_0_fluorouracil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Mitochondrial DNA depletion syndrome 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.856
GSE148692,GSE148695_2_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
X-linked mental retardation with cerebellar hypoplasia and distinctive facial appearance	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.528
HCC1937	DepMap CRISPR Gene Dependency	1.0	3.47098
IL23R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00749857
BRD-K49424866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.45483
GSE70499_5_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CUL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4446
DA-07-LL18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222094
BRD-K57937572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10414
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TBC1D7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00933891
GSE125014_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9061835-41523_2022_425_MOESM1_ESM.xlsx-S3_Differential_GEX-Table-S3_Differential_expression_analysis_results_for_SOX10-high_versus_SOX10-low_TNBCs_from_the_TGCA_and_METABRIC_expression_datasets_SOX10	Rummagene Transcription Factor Associations 2026	1.0	null
GSE110178_5_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Mitochondrial DNA depletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.814
LZTS3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00652314
TRPM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00605315
CRCGN015_MCF10A.TP53.M_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4472
ARHGEF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20816
IL1RN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00889284
BRD-K56417082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23218
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2712
TMEM89	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00809555
GSE195503_3_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204031
HOXC13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0421
GSE95077_1_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.01725
PIP4P2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37939
INO80	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00740223
TENM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00629663
PMC6858560-NIHMS1538530-supplement-Supplementary_Tables.xlsx-Supplementary_Table_21-Supplementary_Table_21_Aberrant_Splicing_Events_in_TET2_SRSF2_co-mutated_AML_Patients_from_the_TCGA_cohort_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
ALAD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00525929
CRCGN015_MCF10A_48H:P11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10688
GSE125153_1_v_0_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K05549579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00942
ACAT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00515594
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLC38A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00612588
PMC6962646-mmc2.xlsx-StemCell_Genesets_2018-NANOG_NANOG	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9774615__F1	PFOCR Pathway Figure Associations 2024	1.0	null
HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE149075_8_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10859
IL21	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00665988
BRD-K98934548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0369
ps96	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.673
MAP3K7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00709427
JD-58-MV19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213949
NGFR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00791336
TD-48-XJ84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.345172
AR-35650195-DSRCT-HUMAN-MESENCHYMAL-SARCOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K08476323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06019
TBX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00432645
CRCGN009_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4204
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.0506
GSE80098,GSE80366_0_v_6_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
AS-605240	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
WEE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00561785
BRD-K63330804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22235
CRCGN015_HEPG2_48H:O16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.07684
TRA2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00388385
BRD-K08829593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24367
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE120595_5_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K61491580	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08401
MPPED2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00481575
TKFC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00704364
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.89557
CLDN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00533278
Gynecomastia	DisGeNET Gene-Disease Associations	1.0	null
ORM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00805326
GSE213588_10_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:H11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.52645
EIF2B4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69131
GSE152055_0_v_1_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC19A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00466051
Spinocerebellar ataxia type 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.731097
GSE161842_1_v_2_kdm6b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.84885
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CDK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.004475
GSE88819_5_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BF-97-LS55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204103
BRD-K41999717	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76648
BRD-K44684577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40079
GSE77108_6_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE128240_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POU6F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4575
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.3203
GSE152432_3_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7830_SF3A1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.519683
FZD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00675604
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE137914_0_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IE-49-AI35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246115
CRCGN016_MCF10A.WT.HP_24H:E05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.93687
oltipraz	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51292
GSE85880,GSE85881_4_v_1_tretinoin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE207514,GSE207515_1_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100626_FWM_no dementia_TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04229
BST1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0104165
TXNRD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0040029
GSE171486_4_v_0_ddx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Intrinsic component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.955
GSE95077_1_v_0_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE198165,GSE198166_0_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Inherited metabolic disorder	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
SMC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0173956
GSE58724_3_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K54386075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17619
INPP5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00715394
GSE159678_6_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PFSK1	DepMap CRISPR Gene Dependency	1.0	3.76275
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE101112_6_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Oxidoreductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.087
GSE234340_4_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TGFB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00636657
CRCGN015_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4623
KLHDC8B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00703225
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cardiac muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN011_HEPG2_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4156
GABRR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00802672
GSE90552_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE130956_0_v_1_icaritin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHRNG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0105353
GSE146982_4_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Gluteal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.612
DRD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0036992
chr1_227021269_C_T_b38	GTEx eQTL 2025	1.0	1.06088
GSE48812_7_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nucleoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.005
CRCGN011_HEPG2_24H:D12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35275
HUS1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26926
COL7A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00563823
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.597362
Heart ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.014
SMARCA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00658054
GSE202434,GSE202438_12_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_6_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DVL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00582062
Proximal Muscle Weakness	DisGeNET Gene-Phenotype Associations	1.0	null
GSE115542_5_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE203308_7_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCKIPSD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00698318
GSE142684_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7029036-41598_2020_59469_MOESM2_ESM.xlsx-NR4A1_and_DHE_p_0_05_1_5FC-Gene_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.TP53.M_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01315
IFNA7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00461164
GSE138019_4_v_5_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE221327_6_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
CELA2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00645701
DEFB106B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00521438
GSE230744,GSE237803_0_v_3_hira_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE245270_1_v_3_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SPART	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16926
PNPLA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00704016
FD-49-XC21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.617108
CRCGN016_MCF10A.WT.HP_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14743
Leukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.259
FAAH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0106711
BRD-K96023136	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02684
GSE175787_5_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
DOCK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41912
BRD-K26689527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28606
GSE242290_1_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ataxic cerebral palsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.143
GSE228894_3_v_2_rnmt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171292_5_v_2_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ITGA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00528167
GSE204811,GSE204813_1_v_3_trim29_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_7_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cerebrotendinous xanthomatosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.63
GSE169205_3_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223008_11_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.287873
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.481058
Basement membrane collagen trimer	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.543
LIVF001-015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	8.29591
Developmental Regression	DisGeNET Gene-Disease Associations	1.0	null
GSE179031_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K06790927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8379
ODF3L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0104757
GSE169356_0_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IL22	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0049773
GSE81803,GSE81912_2_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Amino acid metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.632
Familial nephrotic syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.234
CRCGN017_MCF10A.TP53.M_24H:I04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.80784
Alzheimer's disease 18	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.099
BRD-K35517098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35411
Sotrastaurin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.42
PMC11324510-41587_2023_1949_MOESM3_ESM.xlsx-Supplementary_Table6-Supplementary_Table_6_TP53_pathway_genes_list_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_13_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119498_6_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118794_5_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7029036-41598_2020_59469_MOESM2_ESM.xlsx-NR4A1_vs_GFP_adj_pval_0_05-Gene_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
SMIM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00707368
FA-88-II68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.492334
KDM4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00469435
TRPC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00549835
Multiple carboxylase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
Presynaptic density	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.502
GSE195568_1_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147959,GSE147960_5_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.90228
GSE202434,GSE202438_6_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Primary coenzyme Q10 deficiency 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.841
Sum basophil neutrophil counts	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.23979
GABRG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00568834
GSE246911,GSE246913_4_v_1_arid1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10140619-mmc5.xlsx-Beta3_ConVsBSL-Gene_BHLHE22	Rummagene Transcription Factor Associations 2026	1.0	null
DDX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13421
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K98164803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18374
CRCGN015_MCF10A.TP53.M_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2212
PARP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25495
GSE152432_6_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
SIRT5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00654673
phosphate-containing compound metabolic process	GO Biological Process Annotations 2023	1.0	null
NTERA2CLD1	DepMap CRISPR Gene Dependency	1.0	7.24386
CTPS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00601999
Nephrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.482
BRD-K78643409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38389
SLC28A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0104021
BE-73-KD75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301146
GSE143743_0_v_2_c9orf72_human	RummaGEO Gene Perturbation Signatures	1.0	null
EGR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00455417
Cortical blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.265
GYPE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00669481
BRD-K45592944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20686
CRCGN011_HEPG2_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1338
CRCGN011_HEPG2_24H:D06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.99295
GSE95685_2_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149359_2_v_1_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K59821747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3869
PMC12824661-BLOOD_BLD-2024-027020-mmc6.xls-Table_S14-HES4_Up_HES4	Rummagene Transcription Factor Associations 2026	1.0	null
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.503194
GSE115542_2_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease of metabolism	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
GSE143994_0_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
kinase activity	GO Molecular Function Annotations 2023	1.0	null
GSE234289_4_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
MICOS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.954
BRD-K82105033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17776
GSE239578_1_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RAC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00406591
GSE209598_1_v_2_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DHRS3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00655981
ORM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00852251
GSE142430_3_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151782_1_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K40252598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3518
GSE166317_2_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SEPTIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46452
C1orf56	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25256
UGT1A9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0056757
GSE220520_3_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Autosomal recessive spinocerebellar ataxia 18	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.446
ZBTB8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2254
AB-43-XJ34_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222183
GSE149903_3_v_1_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.469
7648_SAP18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.55301
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.786535
PMC9445361-Table_4.xlsx-TP53-P53_pathway_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE207582_2_v_1_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147662_2_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126463_0_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Eye degenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.488
PMC6484770-41388_2018_602_MOESM5_ESM.xlsx-down_P53_vs_con-Unnamed_1_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BHLHE40	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00349062
NETO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00662356
BRD-K83699731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46866
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.36916
BRD-K94913575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0038
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2268
GSE163862_0_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.236
BRD-K97256018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12839
BRD-K11741103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34709
Focal dystonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.545
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182185_0_v_1_pstk_human	RummaGEO Gene Perturbation Signatures	1.0	null
ERMAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09445
WIPI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38271
Organic acidemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.724
MFSD2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00500118
abnormal spatial reference memory	MGI Mouse Phenotype Associations 2023	1.0	null
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K06451913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44704
U2AF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.011537
PIGV	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00561904
GSE104508_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
SOX17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00552716
BRD-K53612668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03667
BCAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39754
HOXB5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.0828
TTLL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10876
PMC9038526-mmc1.xlsx-postCOVID_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
DAPK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00553356
CRCGN011_HEPG2_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0414
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.367257
GSE112860_0_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KA-75-LP02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223668
Tectum mesencephali	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.825
C1QC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00670772
Disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Hypodermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.954
GSE252857_1_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CPT1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00513374
BRD-K57784254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8295
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.022
GSE113106_2_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:A23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1572
BRD-K87812655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0946
MAP4K1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00434795
SIPA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00602495
GSE140937,GSE140938_1_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:C02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41595
PRPS1L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00631032
Pyruvate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.235
PPP3CA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00713822
CD81	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00505572
GSE126463_0_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
IGLL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532327
GSE183316,GSE183317_1_v_2_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:O23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.039
BRD-K36855468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.43213
A549_PF-3845_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142114
BRD-K04848570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2352
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336781
GSE197555_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SSTR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00370417
GSE146982_7_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5557398-13045_2017_515_MOESM1_ESM.xlsx-S8-DUX4_SpecDMCs-Unnamed_3_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
CISD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00917827
GSE110268_2_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE234340_10_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hereditary spastic paraplegia 9B	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.528
QF-71-QI30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.273392
GW 441756	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
chr1_226985776_G_C_b38	GTEx eQTL 2025	1.0	1.36069
TUBB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00466478
ETV2::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3769
PMC5113908-pone.0166185.s004.xlsx-Supp_1-Supplementary_Table_1_mRNA_expression_correlates_with_STAT3_phosphorylation_for_1279_genes_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112860_0_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239688_2_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:H12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48155
BRD-K06002536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2408
LE-01-MT37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.474631
GSE224131_2_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198380_0_v_1_phgdh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10123531-NIHMS1874945-supplement-Table_S7.xlsx-SOX17_BCAT_4TCFKO_peaks-Gene_Name_SOX17	Rummagene Transcription Factor Associations 2026	1.0	null
Podocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.599
ACSS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00555182
Coenzyme Q10 deficiency	ClinVar Gene-Phenotype Associations 2025	1.0	null
Parathyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K20138377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12481
Mitochondrial respiratory chain complex I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.634
CNR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0108166
GSE205163,GSE205164_1_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
OTC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00573439
GSE202434,GSE202438_2_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GA-77-MH38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.43093
DAGLA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00603251
GSE205730,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158969_1_v_2_trastuzumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203072_2_v_3_rpl3l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Acidosis, Lactic	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K99455613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00893
Amyotrophic lateral sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
GZMH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00588096
TOP2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00748376
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.793
Renal tubular acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
Mitochondrial crista junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.669
GSE160246_9_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K63996931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42695
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.82221
GSE226249_2_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ABCC9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00672202
GSE181003_1_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE117212,GSE117214_0_v_1_zbtb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAT1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00582011
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cataract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.308
NR2C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.9022
Fumarate reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.671
Tozasertib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.83
PRSS3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00459213
GSE210505_0_v_1_sox1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SPINK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00798515
Lactic acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.081
FOLH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00955282
GSE220520_1_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K84586608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1151
BRD-K97373334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00423
PMC3807112-srep03041-s6.xls-ELK4-Gene_Symbol_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
NUP210	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03647
CHRNA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0058364
MAPK14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00902992
Nkx2-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.7622
KCNA6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00580488
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.931316
SLC25A12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00690483
SUGT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00985297
PRPF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29125
CRCGN016_MCF10A.TP53.M_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01317
BRD-K73942053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29012
GSE154219_0_v_2_cholestyramine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
P2RY2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0110518
GSE201309_1_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE176093_0_v_1_mineral oil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GZMM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00557252
IL10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00619712
GSE202434,GSE202438_3_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE112962,GSE112963_2_v_1_ddx5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EHF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0056077
Myopathy of extraocular muscle	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.331
A body shape index	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.8
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_body_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.302
GSE68156_0_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Mammary gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRCA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0079906
Fruit capsule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.014
496100500_PCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.59479
Blood Basophil Count (Lab Test)	DisGeNET Gene-Phenotype Associations	1.0	null
KDM6B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0059752
BRD-K05868476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0024
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Primary coenzyme Q10 deficiency 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.185
GSE258991_5_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
INHBC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00679377
EDA2R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00601318
BRD-K36160951	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08145
FAM3C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00423639
MAP3K20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0055919
PMC5550886-cddis2017345x3.xlsx-siRAD21_DEGs_NOT_rescued_by_Myc-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.671274
Autosomal recessive cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.388
496100639_TCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04575
Torcetrapib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.47
GSE203158_5_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42816
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.748382
CISD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0051082
TUBA1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00620351
Inner mitochondrial membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.541
CDH5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0126484
Mitochondrial myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.453
RNF144B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00534186
GSE137144_3_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-54-ON71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272861
BRD-K07142677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.52159
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322028
PTGES	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00547854
BA-15-VE07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.696732
Stat5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.566
GSE196259_2_v_3_gcm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135514_2_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CNOT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72273
ZNF169	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28298
SEC23IP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0096745
ST6GALNAC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00426118
CYP11B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00601149
MTHFD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00365674
WDR83OS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04498
PRMT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00658486
SLC2A6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0045937
GSE215155_0_v_1_golph3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Spinocerebellar Ataxia	DisGeNET Gene-Disease Associations	1.0	null
Ataxia with oculomotor apraxia type 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.026
DPEP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00729912
GSE165682_2_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PLSCR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00406777
GSE144231_3_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235066_4_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
IFI44L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00544834
IGR39	DepMap CRISPR Gene Dependency	1.0	3.52739
KDM3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00463306
ADIPOR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00552908
NDUFB9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00457838
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
MB-46-BT89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20869
OTX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.793
GSE141328_3_v_2_rock2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CHRNB4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00664839
KIT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0571778
CRCGN014_HEPG2_3H:C13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27377
BRD-K42814713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68861
PMC6520398-41467_2019_10148_MOESM11_ESM.xls-FigS1a-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K75746738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14549
GSE232223_1_v_0_letmd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228106_3_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K23405293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18112
GSE202284,GSE202289_12_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TBX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02839
Dehydrodolichyl diphosphate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.785
PMC6300607-41467_2018_7620_MOESM9_ESM.xlsx-common_BRD4-S_KO_MLL-AF9_loci-Unnamed_13_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
BA-95-YU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.596021
Learning disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
GSE166308_1_v_0_pim1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CACNB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00646391
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K05001008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90468
HPSE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00776839
PMC6113333-41598_2018_31192_MOESM11_ESM.xlsx-Sheet1-H1_NFIC_NFIC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K90744477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77276
CCNT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00881192
MYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7145
APEH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00661909
BRD-K33495825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.139
GSE193258,GSE193259_9_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WM115	DepMap CRISPR Gene Dependency	1.0	2.55957
DA-27-BW20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.467923
Uterine endometrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HDAC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532653
PMC11167905-10194_2024_1805_MOESM1_ESM.xlsx-S6-Table_S6_MR_results_of_brain_eQTLs_and_migraine_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K51707293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17869
CRCGN014_HEPG2_3H:D06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11475
NFATC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.79
496100343_TCx_possible Alzheimer's disease_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.38265
EXD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00793851
Muscle Hypotonia	DisGeNET Gene-Phenotype Associations	1.0	null
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.537939
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.046
GP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00513098
GIMAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00782115
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.501047
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11330984-41467_2024_51229_MOESM6_ESM.xlsx-MYC_UP-ID_ENSEMBL_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE102505_1_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K63937112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05991
GSE130676_0_v_1_suds3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE218814_1_v_0_suv39h1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K68984041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14641
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.95174
CRCGN017_MCF10A.WT.HP_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3408
Methylmalonic acidemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.127
GSE213153_1_v_0_ulixertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K53814023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29087
GSE100464,GSE100465_0_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K79735667	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38308
GSE199081_0_v_1_insr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100643_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.14408
BRD-A58937872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23681
GSE223893_4_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Congenital disorder of glycosylation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.053
AB-09-YX02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.10699
Impaired Exercise Tolerance	DisGeNET Gene-Phenotype Associations	1.0	null
GATA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00745246
GSE242083,GSE242098_2_v_4_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K08835142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33626
BRD-K04495110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77015
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.364642
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236929
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
HOXD12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4346
New cell pole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.671
ERF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.529
496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.21714
GLDC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00608574
DOCK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00613752
CRCGN011_HEPG2_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14185
PMC10248509-Data_Sheet_6.CSV--GSE58294_DE-genes_AND_GSE22255_DE-Genes_NOT_Autophagy_NOT_GSE66724_DE-Genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE205021_3_v_2_fenofibrate_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Formestane	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5977
Pou5f1::Sox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.7254
Motor neuritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
AXIN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0066686
GSE219195_1_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242719
MGAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45172
GSE161064,GSE161065_0_v_1_kdm5b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bach1::Mafk	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	46.6754
MRGPRX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00651696
CRCGN016_MCF10A.TP53.M_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9375
FADS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00801113
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.725181
GSE228413_0_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pantothenate kinase-associated neurodegeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.268
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-8_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FD-20-OG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211058
GSE130081,GSE130082_5_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE58724_1_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE212848_1_v_0_pum1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5263239-mmc2.xls-THP-1_-_MLL-AF9-Non-spreading_targets_gene_names_1900_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221327_8_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223797
BRD-K01334037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00968
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.969
DHX9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00726712
GSE133213_11_v_15_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HPS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00598411
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.8629
PICALM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0057052
SHISA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00816393
GSE175787_8_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
STAT5A-24692510-EPITHELIUM-MOUSE-MAMMARY	ChEA Transcription Factor Targets 2022	1.0	null
GSE81803,GSE81912_3_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233647_4_v_6_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DD-74-PJ26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.389479
SLITRK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00446204
GSE189859,GSE189861_4_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SEMA5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23314
RORB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6328
TNFSF15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00529844
GSE202434,GSE202438_4_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
QD-13-FQ44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202256
BRD-K56244705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48332
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.197
GET1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00652567
BRD-K13968264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1505
Organelle envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.27
GSE96544_1_v_0_mebendazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC3371315-NIHMS350140-supplement-13.xls-MCF7-T47D-SK-453_Up_Common_xls-Supplementary_Table_6_Luminal_Signature_Genes_increased_in_all_four_cell_lines_MCF7_T47D_MB-453_SKBR3_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
Coenzyme Q10 Deficiency	DisGeNET Gene-Disease Associations	1.0	null
OLIG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00744213
BAX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00472875
UNC2250	DeepCoverMOA Drug Mechanisms of Action	1.0	0.6
FLT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00601655
ETV5::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5666
Respirasome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.56
ZNF80	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00617414
BRD-K21332842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39891
GSE245390_2_v_1_acss2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
i-AAA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.774
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.431813
Spleen	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K86288396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51522
GSE142684_4_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AKR1C3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00461387
BRD-K44652223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9425
TO14	DepMap CRISPR Gene Dependency	1.0	2.00897
BRD-K89742282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32439
GSE207914_5_v_6_nudt7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5474565-onc2016488x2.xlsx-Table_S4_MLL_Target_Genes-THP-1_MLL-AF9_target_genes_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE118794_2_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE162739_4_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PROC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00663007
THY1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00873429
TFPI2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00828129
GSE205163,GSE205164_5_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K94196749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44159
LIVF001-016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20648
PMC10361959-41419_2023_5985_MOESM1_ESM.pdf-1619-ZNF446_ZNF446	Rummagene Transcription Factor Associations 2026	1.0	null
TADA2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00614832
BRD-A04231641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77126
IL1RL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00616732
CRCGN015_MCF10A.WT.HP_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.07545
HAMP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00496422
SULT1E1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00652305
Thorax	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
vacuole-mitochondrion membrane contact site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.882
F11R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00820452
CH25H	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00566669
DC-47-KV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.788675
AE-39-DG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236491
GSE48812_8_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Glomerular epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.594
GSE82032_3_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
kasugamycin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82869
BRD-K04399953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53414
BRD-K42679315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.25604
GSE184892_4_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAGI2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00621071
GSE234289_3_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
ASPH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00377882
MME	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532801
JB-14-TF61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240518
CHRNA7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00646421
X-linked cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.099
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K81656074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04414
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.05212
GSE168807_2_v_8_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.732313
TIFAB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00569997
RASopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.1
Nephrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.509
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SUPT20H	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.005618
GSE169356_0_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PTPRJ	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00582576
BD-61-OO16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293134
PMC10140619-mmc5.xlsx-Rank_Beta1-Beta3-Gene_BHLHE22	Rummagene Transcription Factor Associations 2026	1.0	null
KCNC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00677826
AA-22-UI44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.574708
Nutlin3a	DeepCoverMOA Drug Mechanisms of Action	1.0	1.6
AC-36-TL21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.353289
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
WARS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00667553
GSE153871_4_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BE-81-QL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.339965
GSE48812_9_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3651
HE-80-BQ08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.326472
BRD-K80945184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07786
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_3hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
SKIC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00382945
Gata3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.1726
BRD-K13922961	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57272
GA-28-SS67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.287923
LGMN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00568611
BRD-K38791044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00588
GSTM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00698064
TMF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00806007
GSTO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32725
BRD-K18512209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.48384
OA-54-FL10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202095
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_14_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K03381861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07413
GSE180185_7_v_10_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MDAMB436	DepMap CRISPR Gene Dependency	1.0	2.46644
GSE80098,GSE80366_0_v_5_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE128333_4_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:D16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46585
GSE234637_3_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-15-EL49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.328617
ZNF75D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.4561
AE-71-CB15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228722
EDEM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0094928
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8924
IL10RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00574408
BRD-K61772027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94916
GSE101527_0_v_1_smad4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K44003352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26633
Hypolipoproteinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.167
GSE136627_3_v_1_hdac4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.1847
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K43767732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85517
GSE95826_4_v_1_tcra_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AAMP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00689552
GSE157383_3_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K15019832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0182
GMP reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.532
BRD-K63375777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62496
Vitamin metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
GSE149901_2_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Migraine with aura	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.304
GSE138633_2_v_0_bag3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Barth syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.481
JP-4-043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19774
BRD-K07298353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63655
PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Gene_Name_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K00970182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24122
protein modification process	GO Biological Process Annotations 2025	1.0	null
GSE169697,GSE169725_0_v_5_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prdm5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.6473
GSE152441,GSE152442_0_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ARHGDIB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00566711
GSE48812_3_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.507289
AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0225
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.577372
BRD-K39649774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57197
NCIH747	DepMap CRISPR Gene Dependency	1.0	2.0906
Lymphocyte percentage of white cells	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.65229
PMC4494960-oncotarget-06-12587-s002.xlsx-LNCaP_MYC_Microarray-Table_S1_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
CHCHD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24408
Mitochondrial small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.764
K562_Lenalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154194
abnormal skeletal muscle morphology	MGI Mouse Phenotype Associations 2023	1.0	null
Citrullinemia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.002
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8505
CTSL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00638828
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.57219
AA-58-FJ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.38726
CE-15-DU45_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.356397
PDE9A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00623541
PPP4R2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00539953
BRD-K48780709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09278
PMC9634663-DataSheet10.xlsx-K562-MYC-AID_RNA-Seq_1326_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182680,GSE182683_10_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.29762
GSE125014_6_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lixivaptan	DeepCoverMOA Drug Mechanisms of Action	1.0	0.39
ENO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17491
ZFP30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46008
Retinal degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.483
4805_MAP2K7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.546397
GSE146982_4_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K94099082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17723
GSE217201_1_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SFRP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00679294
CRCGN017_MCF10A.WT.HP_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.281
SLFN12L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0070089
GSE181003_3_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE99875_2_v_0_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Trunk	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE188832,GSE188835_0_v_1_irf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233647_4_v_5_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE183890_7_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE231799_3_v_1_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kearns-Sayre syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.179
CRCGN015_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.14379
SLC8A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00501848
CRCGN008_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.87365
PDE-9i	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.39
PANX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00461066
GSE225735_0_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_triplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_prom_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146074_0_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FE-64-KC49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.585332
Second instar larva	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.741
BRD-K72675584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21726
BRD-K39222068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77096
NOP10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00613212
CRCGN017_MCF10A.WT.HP_24H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0145
BRD-K91696235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.853
KAT2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00905804
GSE130401_6_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-M15413738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22689
Ptosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.668
HB-24-GP45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.341427
BB-79-AG41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.316703
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	1.0	0.868169
GSE158834_10_v_8_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JVM3	DepMap CRISPR Gene Dependency	1.0	3.03626
GSE134191_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K11874023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10489
SPATC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0099674
BRD-K83370434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14856
BRD-K73357010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03234
Cysteine synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.63
GSE193282_3_v_1_cd44_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.044
TPCA-1	DeepCoverMOA Drug Mechanisms of Action	1.0	0.71
CRCGN017_MCF10A.WT.HP_24H:I16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5353
GSE239578_0_v_6_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_11_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE221633_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205163,GSE205164_2_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE125219,GSE125221_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:J20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08683
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
IP6K3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00565371
GSE180525,GSE180528_1_v_0_tbx3_human	RummaGEO Gene Perturbation Signatures	1.0	null
RIEG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0062306
GSE213588_8_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.66656
CETP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00615036
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.377725
STAG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0175634
DRAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00784988
PNISR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34381
P2RX4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00976069
PMC12234789-41467_2025_61560_MOESM3_ESM.xlsx-Supplementary_data_1-Only_YY1_IP-MS_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE197850_4_v_2_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K57226184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10922
A2780	DepMap CRISPR Gene Dependency	1.0	2.12028
Charcot-Marie-Tooth disease type 2EE	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
CRCGN017_MCF10A.WT.HP_24H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32577
GSE146074_9_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCCS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11121
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-All_targets_genes_names_2597_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.834
CACNB4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0054013
GSE154577_7_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K65828139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29562
GSE135030_11_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
IL17F	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00665529
MCF7_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135315
BRD-K96069147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23374
BRD-K81574470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19502
SMC6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0103795
GSE234637_2_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205163,GSE205164_3_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
Rhabdomere	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.592
STAT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5709
FD-62-ZB67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.345726
CRCGN015_MCF10A.TP53.M_24H:D24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4362
Stomach	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE201217_4_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE123943_1_v_3_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE124410_2_v_5_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Nearest_Ensembl_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
PDXDC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00480148
GSE71468,GSE76476_0_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-Non-spreading_targets_gene_names_2497_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
IL13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00671743
GSE186287_2_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KDM4C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00430802
RNF114	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0094
SLC7A8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00599221
BRD-K39326623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1003
NR2C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.0201
Epilepsy	DisGeNET Gene-Disease Associations	1.0	null
HDAC5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00900844
CRCGN011_HEPG2_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34795
Chronic kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.196
STAT4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00537613
Increased Csf Lactate	DisGeNET Gene-Phenotype Associations	1.0	null
SLC4A11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00925436
GSE144115_1_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6924
Autosomal recessive spinocerebellar ataxia 27	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.311
clobutinol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24807
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_10_ZZZ3_ChIP-seq_in_shNT-Genebody_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
TECR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.74976
BRD-K89110518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24982
GSE133213_9_v_15_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Central nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
CRCGN015_MCF10A.WT.HP_24H:I07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.69191
GTSF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00712369
CRCGN012_HEPG2_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21533
TNFAIP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00558
AC-97-KP88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21884
Paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.424
JMJD8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00545553
BRD-K71123535	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67721
ATP8B4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00542447
LIVF001-022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00217
ZB-16-BR73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.693943
CRCGN010_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3325
IL10RB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00684292
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.169
PMC5045215-pgen.1006334.s018.xlsx-p53_pathway-S10_Table_Gene_set_enrichment_analysis_GSEA_for_p53_and_MYC_pathways_Related_to_Figure_10B_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
BX 912	DeepCoverMOA Drug Mechanisms of Action	1.0	0.82
CRCGN011_HEPG2_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.03405
CRCGN016_MCF10A.TP53.M_24H:J11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13607
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF-_SURVIVAL-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
succinylcholine-chloride	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40622
SLC7A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0037227
ICOS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00604887
Epileptic Encephalopathy	DisGeNET Gene-Disease Associations	1.0	null
BRD-K78618254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16784
ARID1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0129654
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
BRD-K92079609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47347
IKBKG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0203266
GSE193258,GSE193259_2_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AZD 6482	DeepCoverMOA Drug Mechanisms of Action	1.0	0.91
CELSR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00605825
CAKI1	DepMap CRISPR Gene Dependency	1.0	5.8575
CPS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00686086
GSE255432_7_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.00115
NB-12-ZK38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.360892
GSE125153_1_v_3_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Adipose tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.676
BRD-K40300525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2499
GSE214335_1_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:F08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.72065
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.634
SLC22A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00671061
BRD-K02833343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0475
Glomerulonephritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.357
Cytochrome o ubiquinol oxidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.922
CDKN1C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00502128
TET2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00983346
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-7_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
496100328_TCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.84291
CRCGN015_HEPG2_48H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16342
GSE120612_4_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BNIPL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0052518
SIGLEC14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00840474
MGP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0120531
GSE211262,GSE211263_2_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRYBB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0130707
BRD-K81006490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16345
2236_DLAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.613747
GSE169152_3_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135352_2_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CF-24-KQ98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.276051
BCL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00496363
PMC10864182-41588_2023_1596_MOESM4_ESM.xlsx-ST12_Significant_Genes_combine-Supplementary_Table_12_Genes_prioritisation_combining_FUMA_MAGMA_Hi-C_MAGMA_and_TWAS_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE198165,GSE198166_5_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K25675728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13625
Salivary gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTPBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00663657
PMC7455079-jciinsight-5-140380-s227.xlsx-Supp_Table_8-ILL1_T_Cells_FOXP3_FOXP3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE141328_1_v_0_rock2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTPBP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00978925
CTSA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00942002
FBXO22	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00744293
GSE48812_9_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MPIG6B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00512991
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-4_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE228106_0_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SLC26A9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00575565
BRD-K10325583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07349
GSE209582_1_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CD-35-BD44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.673732
GSE137144_5_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_7_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
1197_CARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.515064
PCSK6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0101365
kinase activity	GO Molecular Function Annotations 2025	1.0	null
Promastigote	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.691
BRD-A63590986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1023
PAICS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00363848
TSPO	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00620432
TRPV5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0062668
HOXA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6137
GSE61117_0_v_1_trim24_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6961
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_result_of_MR_analysis_and_sensitivity_analysis_for_DLco_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BE-31-XV38_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.362171
ETV5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00870335
BACH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8301
RETSAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00578378
Primary coenzyme Q10 deficiency 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.371
Cerebellar Ataxia	DisGeNET Gene-Phenotype Associations	1.0	null
GSE186810,GSE186813_7_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RARA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.6202
PC-62-AQ92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213754
Sensory peripheral neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.148
FD-62-ZB67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.255486
FGA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0128174
GSE135514_2_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.099
GPR65	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00512293
BRD-K20951097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52671
IL1RAPL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00647992
ILDR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00502689
BRD-K57748937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74389
Hypogonadism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.349
PTPN14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00532097
AD-18-XC14_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226579
GOT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00742271
GSE178714_5_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22163
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251591
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
FOXM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00569849
AC-84-QG99_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246258
GSE92364_0_v_3_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HSD17B2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00732372
BOLL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00867987
GSE157050,GSE157051_2_v_4_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MED17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17638
methyl-dopate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.56869
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.545
Skeletal muscle	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
EAST syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.244
GSE114258_3_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K34209560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72198
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K74267000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14781
EBI3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00615327
Uterine adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.568
Nystagmus	DisGeNET Gene-Disease Associations	1.0	null
BRD-K81314458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27851
BRD-K57572982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8675
CRCGN015_HEPG2_48H:C05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08909
PLG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00570612
Dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
NEURL1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00994951
BRD-K43023353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.085
ACAD8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00497989
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE70499_3_v_6_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CALCA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00465731
PMC11585558-41467_2024_54547_MOESM8_ESM.xlsx-TP53_vs_WT_DEG_FFPE-gene_name_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
RPL22L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00662877
AM-095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53442
GSE202434,GSE202438_2_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RB-42-MC53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259552
GSE116810_2_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
SCCPDH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00552653
GSE224599_0_v_1_tfcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12486367-Supplementary_Data2.pdf-246-NFIC_NFIC	Rummagene Transcription Factor Associations 2026	1.0	null
SLCO1C1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0069797
CACNB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00873915
GSE149075_3_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10794847-mmc5.xlsx-PIAS1_KD_down-Table_S4_Differentially_expressed_genes_with_PIAS1_knockdown_in_the_progenitors_state_Related_to_Figure_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE157383_6_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE220613_0_v_1_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211226_1_v_2_sirpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DE-98-FC24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.525192
CRCGN015_MCF10A_48H:B19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05337
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.7408
Dystonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.295
Leber hereditary optic neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.794
PRKN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00669876
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	4.71803
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.71278
RTP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00922807
GSE60217_1_v_8_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BA-59-EN38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272902
GSE160001,GSE160670_1_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE162739_8_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Coenzyme Q10 deficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.296
GSE233049_1_v_3_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K42496940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02192
NR1H4::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3879
BRD-K79562803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57888
BRD-K32882942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43185
Visual pathway disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.231
CRCGN015_MCF10A_48H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22814
GSE120612_4_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF814	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24144
GSE231799_2_v_5_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FASN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00506022
GSE147366_1_v_0_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:G23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0847
ASH2L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0102023
HAL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00557856
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_1_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
INTS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66669
GSE208254_4_v_5_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE164884_2_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE252864_0_v_3_smad4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FCGR1BP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00438861
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.257
GSE87144_3_v_1_rorc_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Alport syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.115
ZNF707	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32803
TBKBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39878
BRD-K76713927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63245
GSE217363_4_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211226_1_v_0_sirpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE179031_3_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE125211_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ALDH1A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00475874
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.024
NA-16-OJ70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.418025
GSE151782_4_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K21595913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19469
GSE223008_11_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7029036-41598_2020_59469_MOESM2_ESM.xlsx-NR4A1_Targetome-Genes_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4944136-srep28995-s2.xls-ARGFX-gene_ARGFX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CCT128930	DeepCoverMOA Drug Mechanisms of Action	1.0	1.19
BRD-K48056188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31142
GPER1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00737587
1718_CNOT3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.557931
GPR119	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00544151
deafness-dystonia-optic neuronopathy syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.344
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.4133
Metabolite levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.552288
GSE153867_6_v_3_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE101239_3_v_0_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K15157905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49205
GSE152432_3_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K18003296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03653
GSE193351_1_v_3_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE209601_2_v_1_mef2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Hereditary ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.723
TTC7A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00461514
BRD-K90977883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53431
KCNQ4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00970433
GSE152699,GSE152723_3_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE261563_0_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
SOX4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0038792
A375SKINCJ3	DepMap CRISPR Gene Dependency	1.0	6.53317
PIK3CA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0155035
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
UCN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00652215
Early myoclonic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.78
NMUR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00916221
RIT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00894695
GSE121824,GSE121826_0_v_8_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE94849_1_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
methylparaben	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24255
CDX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00894852
KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.91202
CRCGN011_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7323
JAK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00705301
Autosomal recessive spinocerebellar ataxia 12	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.365
GSE120370_0_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NUP50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12066
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01984
BRD-K16727544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15751
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MELAS syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.671
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.276
ProVWX complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.507
GSE221327_1_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11953390-41598_2025_94761_MOESM1_ESM.xlsx-Table_S3-Table_S3_The_result_of_MR_analysis_and_sensitivity_analysis_for_CKD_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
Mitochondrial disease	ClinVar Gene-Phenotype Associations 2025	1.0	null
FOXO1::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.3548
CRCGN016_MCF10A.WT.HP_24H:K14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32381
Extraocular muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.826
GSE190177_1_v_0_sgpl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_8_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HDAC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00805248
PMC11630641-mmc8.xlsx-Human_1000cell_NOT_identified-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GRIK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00659819
GSE179974_3_v_0_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:M11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8212
BRD-K03937692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05772
Plastoglobule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.972
BRD-K58743752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44596
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_12_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
Spinocerebellar ataxia with axonal neuropathy 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.952
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.93
Fanconi syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.338
Refsum disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.313
CRCGN010_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11659
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.661
GSE254649_3_v_0_cstf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TNFRSF12A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00723799
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.537246
GSE154767_2_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AA-68-OJ16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.425136
TRIM29	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00710748
Nephrotic syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.488
SFXN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00715545
ZB-29-GC39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226904
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.28103
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
496100592_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.28694
GSE184884_6_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE167956_4_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE133691_2_v_0_lgr5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Abetalipoproteinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
Glomerulosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.707
GSE237040_2_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FD-62-ZB67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.311842
BRD-K81450614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17881
SPEGNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4183
GSE221327_6_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152441,GSE152442_6_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.802
MCF7_ABT-737_1µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0116718
GSE214931_4_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.59645
GSE198794_0_v_3_usp18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE60217_1_v_9_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ETV5::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4301
CRCGN017_MCF10A.WT.HP_24H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8531
RRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63911
PMC5637904-PATH-243-193-s016.xlsx-human_up_in_fat_SOX11-Unnamed_7_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148066,GSE157787_5_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KIR3DL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00473923
ENOX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00835739
TMEM156	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0089872
LY6G6F	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00528765
SYPL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00879574
STAMBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00558928
GSE147662_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
Yaws	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.173
PMC11330984-41467_2024_51229_MOESM6_ESM.xlsx-MYC_UP-ID_SYMBOL_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
CATSPER1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00635571
CRCGN017_MCF10A.TP53.M_24H:L24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15085
GSE92965_0_v_1_klf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13541
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4823830-ncomms11171-s4.xlsx-high_in_shRNA_TCF1-GeneSymbol_HNF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Strabismus	DisGeNET Gene-Disease Associations	1.0	null
GSE116810_2_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.86583
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
KDM4E	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00504484
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_2_TBRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
Strabismus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
BRD-K41709602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63015
BRD-K63436213	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13197
Nigrostriatal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.666
ORAI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0124537
GSE48812_4_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Neonatal period electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.768
GAD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00768356
OPTN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00470263
CRCGN015_HEPG2_48H:D23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13258
RSL24D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00593709
PC-62-AQ92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.283737
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6442
Global developmental delay	ClinVar Gene-Phenotype Associations 2025	1.0	null
Melas Syndrome	DisGeNET Gene-Disease Associations	1.0	null
NDUFAB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0061428
BRD-K76755163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85524
ACY1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00457385
BRD-K41349710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.75386
BRD-K68433511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27929
GRACILE syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.493
GSE193258,GSE193259_2_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLC7A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00726949
GSE92364_0_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_9_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146982_7_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NDUFC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00574936
GSE186112_1_v_0_med23_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GRIK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00940873
CST3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01074
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE175787_11_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TUBA4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00755186
MYO9B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00746124
CEACAM16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00606712
GSE195513_0_v_3_cpeb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXB9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7202
Lens disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
BRD-K92009052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49423
GSE158431_2_v_0_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Dissociated nystagmus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.228
Capsular epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.598
GSE183890_7_v_10_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
S100Z	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00710846
UFSP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00650489
GSE137144_4_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF616	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53494
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4237
GSE129244_3_v_5_lmo2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AASS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00586381
CRCGN015_HEPG2_48H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61287
BRD-K56234278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09478
PRRC2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38977
GSE215109_0_v_2_ep400_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PB-09-OE00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215781
POLB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564888
DSCAML1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00525884
ANXA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00585836
IGDCC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0063318
BRD-K51643438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28493
CRCGN008_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3209
GSE213588_8_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AMPD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00906169
ESRRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.0452
BRD-K82768815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23097
STAT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.1607
GPA33	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00609967
BRD-K69520171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37364
BRD-K39863565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.57819
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S5-Table_S5_The_result_of_MR_analysis_and_sensitivity_analysis_for_FVC_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
VEGFA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00583793
KE-41-JG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2849
GMFG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00851237
PLOD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00752737
GSE162276_2_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BA-04-IG64_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24436
PMC10123531-NIHMS1874945-supplement-Table_S3.xlsx-SOX17_BCAT_cobound_coreg_peaks-Gene_Name_SOX17	Rummagene Transcription Factor Associations 2026	1.0	null
U87MG_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	2.77506
MTA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0066217
SHROOM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00875115
PMC7538956-41467_2020_18817_MOESM1_ESM.docx-15-P53_pathway_gene_set_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5637904-PATH-243-193-s016.xlsx-human_up_in_fat_SOX11-Table_S5A_Upregulated_genes_in_tumours_from_DCIS-SOX11_cells_compared_to_DCIS-lacZ_cells_injected_into_mammary_fat_pad_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
GSE110268_1_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-67-HS65_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252955
Mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K98876398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33399
GSE203158_12_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HOXC11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4822
642_4014_9503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14717
GSE207135_2_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Ethylmalonic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.353
NDUFV1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00875835
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SPR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00369417
GSE60217_1_v_0_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:A11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.54145
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE195663_0_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KCNK9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00819623
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.335844
PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K23694339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54959
Fibromyalgia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.141
ZKSCAN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0836
GSE125007,GSE125008_1_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K52194153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09052
GSE149903_5_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CLOCK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0106204
NAP1L4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00572311
10400_ZNF497_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.668512
GSE247764_1_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AA-68-OJ16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299326
impaired coordination	MGI Mouse Phenotype Associations 2023	1.0	null
SC-25-HE80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.349853
CRCGN011_HEPG2_24H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55745
BRD-K20549184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20907
PLAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00908752
RPL30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71612
KIF23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12172
GSE207787_1_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6855629-pone.0225186.s008.xlsx-Sheet1-DEGs_downregulated_in_SK-N-SH_MEIS1_OE_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
SLC39A14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0102424
ORAI3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00960656
SYNGR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00632868
Primary coenzyme Q10 deficiency 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.257
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
NCOA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00593091
BRD-K87654551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10099
VD-88-MW70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.346885
Brisk Reflexes	DisGeNET Gene-Phenotype Associations	1.0	null
Increased Intramyocellular Lipid Droplets	DisGeNET Gene-Phenotype Associations	1.0	null
STX1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00668339
PTPRT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00812176
C7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0053099
GART	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00617288
GSE152432_6_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195559_3_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SULT2A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00584719
GSE181003_1_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE153867_6_v_8_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:J11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3892
BE-71-AV63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242634
PMC7472860-mmc1.xlsx-Table_B-P53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE163052,GSE163198_5_v_0_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02089
BRD-K16525290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47627
CRCGN014_HEPG2_3H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28262
BRD-K93817456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25466
RHOV	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00879956
JE-55-OJ53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.364365
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RD-90-OY66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243609
MEOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.2995
CRCGN015_MCF10A.TP53.M_24H:H18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45365
CH5132799	DeepCoverMOA Drug Mechanisms of Action	1.0	1.62
EVX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.819
Oliva	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.203
MCF7_Enzastaurin_1µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123442
CDK8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00667138
Friedreich ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.213
DUXA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1945
SLC43A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00631064
BRD-K48407262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52174
PMC12499388-ADVS-12-e01774-s002.xlsx-Table_S1-Table_S1_Differentially_Expressed_Genes_between_wild-type_and_TET3-knockout_PANC-1_cells_TET3	Rummagene Transcription Factor Associations 2026	1.0	null
Hereditary spastic paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.395
CRCGN017_MCF10A.WT.HP_24H:I08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44895
SLC39A8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0193673
CD9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00421402
BRD-K49681465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31723
GPI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0045646
CRCGN013_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.652
NMB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00689639
CRCGN017_MCF10A.WT.HP_24H:J14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.002
CCKBR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00391265
GSE158834_1_v_9_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K93109423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40112
TACR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00551505
GSE114232_8_v_6_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IRF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00578306
GSE213588_9_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K17152303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19285
GSE169152_5_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.450763
LSM6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00433161
Cerebral degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
Midostaurin	DeepCoverMOA Drug Mechanisms of Action	1.0	0.73
GSE149035_1_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE219195_4_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DHCR7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00477376
GSE146612_2_v_0_amiodarone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:P07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7463
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.466473
HSD11B2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0077769
IL11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00669898
ATP-binding cassette (ABC) transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.826
CHOP cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.593
BBOX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00492244
ZNF468	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31657
Polyneuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.571
Guard cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.341
CRKL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0777198
GSE169205_0_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2882
BRD-K19527338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12251
BRD-K57497543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70152
GSE206226_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE207282_1_v_0_polydatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormal nervous system electrophysiology	MGI Mouse Phenotype Associations 2023	1.0	null
HES1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00468352
VPS4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00398148
BF-22-EP86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212872
BRD-K18783332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0323
GSE48812_9_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lymph node	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE88819_5_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K67448189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16749
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.753355
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.436549
K562_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137881
GSE146074_0_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_hexaplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171837_3_v_1_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10746608-427_2023_709_MOESM5_ESM.xlsx-NR3C1_partners-NR3C1_known_protein_partners_according_to_BioGrid_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
HTR5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00762802
ETV5::HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0747
Classic citrullinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.157
GSE175571_3_v_2_acsl6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151494_1_v_9_nrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE220520_5_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE154577_6_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cervical dystonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.4
GSE114013,GSE114014_0_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE203060_0_v_1_kdm4c_human	RummaGEO Gene Perturbation Signatures	1.0	null
SIGLEC5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00725979
NR2C2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00659162
Hereditary spastic paraplegia 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.237
PREP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00421272
GSE247775_1_v_0_tmprss2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FC-22-VC55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288544
PMC10534007-Table_3.xlsx-S3_unique_up_MSC_B-48_elements_included_exclusively_in_BFTC905_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
succinate-CoA ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.865
CRCGN016_MCF10A.TP53.M_24H:E24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66322
CYP3A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00553311
SLCO1A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00978571
AE-14-NN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20601
SPATA5L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00903734
CRCGN017_MCF10A.WT.HP_24H:K18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4584
PHOX2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.2799
S1PR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00743001
GSE234340_1_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NGF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00635999
IL6ST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00674592
SLCO4A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0113
VGLL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00534562
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
STAT6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00816409
AE-39-DG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.636632
LIVF001-021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.38915
ARFRP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00810696
GSE70499_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.025
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.932
PMC9882185-media-4.xlsx-Neuron_KD-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
KAT6B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00378632
BRD-K95114614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3368
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-MYC_UP_V1_UP-Ensemble_gene_ID_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE137144_4_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AA-62-HP31_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245908
Cataracts (operation)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.12218
GADD45B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00376096
GSE48812_7_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2458
IER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.35403
GSE112860_0_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MMP23A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0116726
SDHC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00722425
OSI-027	DeepCoverMOA Drug Mechanisms of Action	1.0	1.58
MERO82	DepMap CRISPR Gene Dependency	1.0	9.26188
NB10	DepMap CRISPR Gene Dependency	1.0	2.12281
PMC11058205-42003_2024_6202_MOESM6_ESM.xlsx-Data3b_DirectGene_FOXA1-Data3b_Genes_directly_regulated_by_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:F15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3505
BRD-K67270926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20752
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247646
CRCGN015_HEPG2_48H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13774
GSE137653_4_v_0_siglecf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K57155690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44294
fleroxacin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.56076
BRD-K18775867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40678
GSE234334,GSE234336_1_v_0_zhx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K76734722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07777
ELK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0137237
HD-51-KD29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.307976
SAMD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00583573
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203469
GSE241862_0_v_3_cabozantinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.25152
TIM23 mitochondrial import inner membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.914
CRCGN015_HEPG2_48H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13837
RPAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94309
MINDY1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00585662
Sphingolipidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.192
PMC11474056-pnas.2404841121.sd01.xlsx-Supplemental_Table_8_Fig1G-H-Supplemental_Table_8_Transcriptomic_overlap_between_LPS_and_Sepsis_and_or_Tuberculosis_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
NR2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	104.069
BRD-K47865468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56926
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268001
RBM22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0123
PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_significantly_downregulated_739_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
ECE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00617721
Mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
DE-98-FC24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211983
LCK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00645616
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239876
CA-42-YI34_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.391065
GA-28-SS67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.37061
protein modification process	GO Biological Process Annotations 2023	1.0	null
skeletal muscle fiber degeneration	MGI Mouse Phenotype Associations 2023	1.0	null
GSE239578_0_v_4_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
C9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00624722
CRCGN015_MCF10A.WT.HP_24H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.51351
Breast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HCRTR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00630812
GSE193258,GSE193259_2_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HLCS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00641184
GSE182680,GSE182683_7_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DHODH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00547222
GSE114992,GSE114993_7_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MBTPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4892
Autosomal recessive spinocerebellar ataxia 14	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.356
CRCGN017_MCF10A.WT.HP_24H:H13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0616
GSE201361_0_v_1_mpst_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE156923_2_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K99022424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36662
CRCGN015_HEPG2_48H:H06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43175
CRCGN011_HEPG2_24H:B05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21165
MAPK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00374924
GSE60837_0_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SLC41A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00687144
ficolin-1-rich granule membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.661
BRCA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24036
ketocholesterol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1207
BRD-K56879482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21875
GSE167956_1_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE105406_0_v_3_ptcd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8390401-12094_2021_2621_MOESM2_ESM.xls-S5-Supplemental_Table_S5_Differentially_expressed_genes_between_cases_with_CM-induced_pY-STAT3_DMFI_1_76_STAT3_Low_v_DMFI_1_76_STAT3_High_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE209598_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CYP1A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00789507
pimasertib	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.22902
PMC6145927-41467_2018_5729_MOESM6_ESM.xlsx-TF_Activity_Genesets-FRA1_UP_FOSL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE88819_7_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AE-32-DP61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209472
GSE189336_1_v_0_nitric oxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.896
FUS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0052019
GSE125007,GSE125008_4_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nephritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.309
LD-69-ZV56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.367856
SW1990	DepMap CRISPR Gene Dependency	1.0	2.86068
CA14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00380194
NPM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00535055
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225266
CF-24-KQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.481636
PP2	DeepCoverMOA Drug Mechanisms of Action	1.0	0.53
BRD-K99833695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04718
Mycophenolic acid	DeepCoverMOA Drug Mechanisms of Action	1.0	1.13
PHF19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00811652
Marinesco-Sjogren Syndrome	DisGeNET Gene-Disease Associations	1.0	null
GSE224004,GSE224005_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.572
KRTCAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00318
Transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.034
CD38	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.006827
Naive CD8+ T cell_Peripheral blood_Human	CellMarker Gene-Cell Type Associations	1.0	null
TIGD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00550289
BRD-K88707941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03066
Twig	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.87
AHCY	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00392653
nomegestrol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60293
GSE123734_1_v_0_mien1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Parkinsonism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.548
Respiratory chain complex III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.345
proton-transporting two-sector ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.178
ABC1_LUNG	CCLE Cell Line Proteomics	1.0	2.48366
PMC5795782-supp_gad.302646.117_Supplemental_Table_S1.xlsx-Table_S1_1-Supplemental_Table_S1_1_Genes_significantly_downregulated_by_ARID5B_knockdown_ARID5B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE110440_2_v_3_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135030_11_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SUV39H1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05448
CRCGN011_HEPG2_24H:B24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1278
FCGR3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0052051
GSE229102_1_v_0_nr2f6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NDUFV2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00823882
PMC4335056-pone.0116726.s005.xlsx-Biol_FT_NOT_QE-GENE_Official_symbol_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE215351,GSE215794_1_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.982
Phenylketonuria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
GSE215086_0_v_1_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K25016708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85525
GSE109913_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1497
BRD-K35667841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31926
IL12RB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0069579
GSE216757_4_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE112860_5_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
EIF4A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00918265
BRD-K97013733	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44582
GSE223008_11_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K17570530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28959
KCNMB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00774728
Kearns-Sayre Syndrome	DisGeNET Gene-Disease Associations	1.0	null
5699_NKX6-1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.553088
ITPRIP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00645737
GSE229973_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K15341710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00259
GSE57397,GSE57399_1_v_0_fbxw7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K86102179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16642
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN017_MCF10A.TP53.M_24H:I02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5139
NARP syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.558
ID-00-IC14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.384459
CRCGN017_MCF10A.TP53.M_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6606
GSE149000_2_v_0_cyp3a5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K64632606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.98801
GSE144443_10_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K16109630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26225
FABP6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00714391
NUP160	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00915664
FA-36-VA24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229667
BRD-K69175109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49187
GSE145215_0_v_3_krt13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DPYSL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00619665
Friedreich Ataxia 1	DisGeNET Gene-Disease Associations	1.0	null
GSE149621_0_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
ENPEP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.008595
QPCT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00493981
DGKK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00570404
BRD-K48987279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35019
GSTA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00613296
CRCGN015_MCF10A.WT.HP_24H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3299
496100504_TCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.1299
BRD-K79497053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52986
BRD-K86584551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56618
LRRC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00468158
oxaliplatin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42135
BRD-K24240386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78084
GSE119498_0_v_10_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Familial isolated deficiency of vitamin E	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.624
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.147
TFEC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00669818
PPP2R5C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00499917
ALDH18A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00356277
BRD-K45271289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.60275
GSE205163,GSE205164_2_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_with_decrease_in_MLL-AF4_ChIP-seq_signal_2198_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A_48H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7182
BRD-K85513726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03831
Optic atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.944
KCNN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00571109
GSE126777_0_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_7_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K27881972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14743
GSE181521_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE229580_2_v_1_creb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236502_2_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210101,GSE210114_6_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114992,GSE114993_7_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242083,GSE242098_2_v_0_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:D14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6018
Cerebellar Dysmetria	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K96737756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.1008
NR2C2AP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96955
496100336_TCx_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.58259
PMC12821819-40478_2025_2173_MOESM9_ESM.xlsx-Supplementary_Table_3a-Supplementary_Table_3A_List_of_Top_1000_Genes_with_the_Highest_Stochasticity_by_JSD_in_the_ATRT-MYC_Subtype_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62272
PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217363_6_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.44525
BRD-K05246869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23344
BRD-K47886441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62451
GSE137914_4_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE215086_5_v_7_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.92583
OLIG2-29049317-MOUSE-SPINALCORD	ChEA Transcription Factor Targets 2022	1.0	null
SHARPIN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00524386
ZBTB24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00781476
TNNC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00642661
BRD-K88670720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53453
BRD-K61283064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57341
ASXL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0061845
Multiple acyl-CoA dehydrogenase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.06
GSE236003_2_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
OPRM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00960529
Mild cognitive impairment	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.087
BRD-K05645732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15406
apramycin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35594
PMC5642521-oncotarget-08-69847-s004.xls-Sheet1-List_of_down_regulated_genes_in_NRF2_KD_A549_cells_FC_1_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30578
CRCGN016_MCF10A.TP53.M_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13772
PRM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00685174
RGS13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00706681
EGR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00568335
Silmitasertib	DeepCoverMOA Drug Mechanisms of Action	1.0	1.18
GSE223893_11_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE143212_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ME2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00547043
GSE169713,GSE169715_1_v_2_tert_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KA-63-FH23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205275
SEMA3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00643662
GSE223008_9_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MILR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00590583
CRCGN017_MCF10A.WT.HP_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3029
GSE151494_10_v_3_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131649_2_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.00326
BRD-K05070188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0809
BRD-K40164971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45719
Colon - Sigmoid	GTEx Tissue Gene Expression Profiles 2023	1.0	6.82006
GSE255432_6_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PB-09-OE00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.363893
Nemaline myopathy 8	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.565
CRCGN011_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6447
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-1_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
LRRN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00658898
Apraxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.412
GSE210101,GSE210114_7_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.425956
CRCGN015_HEPG2_48H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01375
TRAPPC13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00704761
Phosphomannomutase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.106
IF-06-KQ42_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214677
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.678076
GSE152432_5_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.683
AB-21-VE32_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.343489
LPIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.4417
BRD-K72034944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20638
TCEAL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00718843
CGA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00577937
BRD-K45984211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24498
Generalized Hypotonia	DisGeNET Gene-Phenotype Associations	1.0	null
GSE145171_0_v_1_prox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.564
BRD-K46796982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.81556
Marinesco-Sjogren syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.498
CDKN1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00558603
TCL1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00825732
PMC7755667-mr-31-27-s001.xlsx-Table_S2-HALLMARK_P53_PATHWAY_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
Corticospinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.28
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.402027
GSE201309_1_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CATSPER3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0116312
Myoglobinuria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.152
PMC11003700-pbio.3002240.s013.xlsx-siMYCN_RNA_IMR32_48h_q_0_05_1_5-Table_S6_Genes_commonly_and_differentially_regulated_by_MYCN_and_WDR5_in_IMR32_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
Pyramidal Sign	DisGeNET Gene-Phenotype Associations	1.0	null
Spastic ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.271
CENPI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15459
GABRG3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00668114
IFNGR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00786341
TSG101	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28729
PMC10120965-pwac038_suppl_supplementary_table_s4.xlsx-siFOXP1-2_vs_siNC-Differentially_Expressed_Genes_DEGs_in_hCMs_upon_Silence_of_FOXP1_FOXP1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE118816_2_v_1_myo1c_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142684_3_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ubiquinone metabolic process	GO Biological Process Annotations 2023	1.0	null
GSE70499_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K42828928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42404
GSE135030_11_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-3_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE48812_3_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0634
PMC11609822-cd-24-0018_supplementary_table_s8_suppst8.xlsx-Visium_Clusters_DEGs_LR_test_LF-Unnamed_0_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
SPG7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00901843
GSE130246_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE128333_2_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
PLXNA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00567225
PMC9170563-12885_2022_9665_MOESM3_ESM.docx-0-Candidata_target_genes_of_CEBPB_2_CEBPB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217552_3_v_2_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.694598
CRCGN015_MCF10A.WT.HP_24H:J08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07737
GSE196699_2_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168807_0_v_7_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SH4	DepMap CRISPR Gene Dependency	1.0	2.30314
GSE196699_7_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_2_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
THRA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00393513
Bcl11b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.6552
CRCGN011_HEPG2_24H:N07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1746
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE219195_4_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8264
Cerebellar Atrophy	DisGeNET Gene-Disease Associations	1.0	null
HAPLN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00716207
KRT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02921
GSE86507,GSE86509_7_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE92965_0_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1	Rummagene Transcription Factor Associations 2026	1.0	null
EFM19	DepMap CRISPR Gene Dependency	1.0	4.82233
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.605942
HCN4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00595206
GSE242083,GSE242098_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K94445007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95709
ECSCR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00692471
FURIN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0151656
JHH6_LIVER	CCLE Cell Line Proteomics	1.0	2.43648
Autosomal recessive cerebellar ataxia	ClinVar Gene-Phenotype Associations 2025	1.0	null
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.593415
COBL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00602422
TMEM43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30284
K562_Andarine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168526
PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K79523827	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15513
Lipid storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.079
BRD-K67194214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00498
NPTN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00451209
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.3843
CRCGN011_HEPG2_24H:J12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.78115
GSE233647_2_v_3_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE164874_5_v_0_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
EE-23-MF14_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.343193
GSE94814_1_v_3_reck_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K37544873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23881
S100A8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540231
RGS8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00650362
TF-04-RX73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.407315
Debio-1347	DeepCoverMOA Drug Mechanisms of Action	1.0	0.63
HDAC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00926934
GSE169205_4_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ADH7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00620419
DHRS9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0040069
GSE182680,GSE182683_5_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PF-59-CY33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.309031
BRD-K48634117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47769
GSE228413_2_v_5_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE108675_3_v_0_slc1a4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
CDC25A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00583449
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257137
PMC5303304-13073_2017_407_MOESM3_ESM.xlsx-mycn-sy5y-se_single_24DMSO_vs_2-Table_S2_Genes_differentially_expressed_by_24h_RA_treatment_DE_comparison_with_SY5Y-MYCN_control_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE125862_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K12555854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46299
GSE225735_1_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE249893_1_v_0_tfam_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Silique	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.019
protein phosphorylation	GO Biological Process Annotations 2025	1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233872
TMOD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00560024
Ataxia	DisGeNET Gene-Disease Associations	1.0	null
PRTN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00667396
KCNQ3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00740022
SUM-185PE cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.794
CRCGN017_MCF10A.TP53.M_24H:A24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34668
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2512
CRCGN015_HEPG2_48H:P16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.87625
GSE196699_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193258,GSE193259_9_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE88819_7_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IL12B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0108719
GSE210885_3_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142430_2_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SLAMF8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00670264
SRF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.2937
DC-23-UM36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227526
GSE158502,GSE158506_3_v_0_fat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286401
GSE207514,GSE207515_2_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.836
BRD-K92398088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56717
Cybrid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.916
569_ASB8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.08982
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE229580_2_v_3_creb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
NR2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.8622
KCTD8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00623446
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.2066
GPATCH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00619515
GSE110178_5_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE95077_5_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cataracts	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.45229
GSE157050,GSE157051_2_v_9_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CCDC50	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00661781
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.462807
PMC7403583-41598_2020_69884_MOESM2_ESM.xlsx-Sheet1-Supplementary_Table_1_Differentially_Expressed_Genes_FDR_q_0_05_in_U2932_ROCK2_KD_vs_Scrambled_shRNA_Constrols_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE173873_10_v_11_stra8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXO1-32281255-CHONDROCYTES-HUMAN-OSTEOARTHRITIS	ChEA Transcription Factor Targets 2022	1.0	null
ENPP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61893
SERPINB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00467691
GSE148066,GSE157787_5_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.48895
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.04278
CRCGN011_HEPG2_24H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.427
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.310242
CRCGN012_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28134
ERMES complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.695
MOB3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98842
496100376_FWM_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.1678
GSE232558_0_v_1_fbxl12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GPX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0124029
GSE219274,GSE219276_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cerebellar hypoplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.261
CARM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0098133
SYNPO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0061214
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_and_sensitivity_analysis_for_IPF_susceptibility_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
6724_PRDM15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.56006
GSE110440_1_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_15_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K02240568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04757
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.334693
BMS-536924	DeepCoverMOA Drug Mechanisms of Action	1.0	1.33
GSE229671,GSE229673_3_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ARL5C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00658112
MB-15-ZF03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.499494
USP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0106958
GSE248770_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:J20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.71835
GSE135030_11_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Electron transfer flavoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.294
BRD-K94344234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58107
CRCGN015_HEPG2_48H:C03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59238
NAMPT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00667022
mL167	DeepCoverMOA Drug Mechanisms of Action	1.0	0.35
IL15RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00839382
GSE102870_1_v_2_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0067155
GSE201309_4_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TRIM62	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59233
Dystonia	DisGeNET Gene-Phenotype Associations	1.0	null
AF-30-GH67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20629
JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.05
SIGLEC11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0135244
GSE224877_2_v_1_pctp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198036,GSE198041_0_v_2_sox9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mafg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.2791
CRCGN010_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0121
LIPF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00618407
Shukla-Vernon syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
Riboflavin and CoQ disorders	WikiPathways Pathways 2024	1.0	null
GSE213588_8_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Motesanib Diphosphate_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0226591
BRD-K78363521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52896
NR6A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2877
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.8987
PMC9515221-41467_2022_33137_MOESM11_ESM.xlsx-Fig4D_Combo_vs_Ro_P53_GSEA-RANK_IN_GENE_LIST_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5797
GJA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00912183
CDC20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.236
GSE216538_0_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:D22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.89905
PMC11151076-ADVS-11-2306486-s002.xlsx-TSPYL1_FOXA1_targets-DDB2_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
IKZF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00359902
GSE205163,GSE205164_1_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9038526-mmc1.xlsx-healthy_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Neutrophil count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.25229
FD-20-OG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214512
Myoclonus	DisGeNET Gene-Phenotype Associations	1.0	null
TNFSF18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00724321
phosphorylation	GO Biological Process Annotations 2023	1.0	null
CRCGN011_HEPG2_24H:E18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3105
DPP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0115639
GSE223008_4_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157594_6_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
13c4	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.727
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.865
GSE120413,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GJC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00676532
STBD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00720657
PMC9404532-NIHMS1788564-supplement-Supplementary_Tables_1-8.xlsx-Supp_Table_6-MYC_UP_V1_UP_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE109285_3_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FOXA1-26457646-LHSAR-HUMAN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
IGSF6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0107874
CRCGN011_HEPG2_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.141
PMC7617064-EMS151900-supplement-Extended_Data_Figure_5_Source_Data.xlsx-CLC_D9_DEG-Logfold_change_threshold_1_0_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE130246_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
5244_MRPS14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.527941
A549_Aminoglutethimide_10µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144429
BRD-K98474331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03675
BIRC5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0060469
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.3247
PMC7617064-EMS151900-supplement-Figure_7_Source_Data.xlsx-HLC_D9_DEG-Logfold_change_threshold_1_0_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
HTR7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0063304
SLC35E3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03251
IFI44	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00917804
HCC202	DepMap CRISPR Gene Dependency	1.0	3.36012
BRD-K42247636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2681
GSE244233_1_v_0_quercetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Irf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.1945
Hemicellulose network	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.784
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.141
CRCGN015_MCF10A.WT.HP_24H:E11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.51174
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE144484_2_v_3_mllt6_human	RummaGEO Gene Perturbation Signatures	1.0	null
MEOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2728
CRCGN017_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.89085
SLC9A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00461106
BRD-K71243741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01262
PDE1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00779184
Moderate Intellectual Disability	DisGeNET Gene-Disease Associations	1.0	null
CA5B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00538113
MORN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0113817
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE153867_6_v_4_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mafb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	51.8618
BRD-K78889331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09895
GSE182680,GSE182683_10_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
SRR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00563415
BRD-K50950731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4986
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE214212_2_v_1_chd6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-23-FM46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22144
GSE158834_10_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-10_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.651
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.664783
GSE217105_0_v_1_gemcitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.07
ABI3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00684347
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.293345
GSE87617_1_v_0_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
dihydroergotamine-mesylate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26565
BRD-K05635176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12482
GSE137325_2_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CCT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91454
Autosomal recessive spinocerebellar ataxia 10	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.881
Refractive error	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.2
JEG3	DepMap CRISPR Gene Dependency	1.0	5.93863
FBXO11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00429063
OSCAR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00680328
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DDAH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00926752
FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.2227
CRCGN017_MCF10A.TP53.M_24H:I16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45696
TUBG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0066812
GSE148657_2_v_1_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE159049_1_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.8503
ENC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00872023
FAM53C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10356
PMC11490525-414_2024_3265_MOESM3_ESM.xlsx-Table_S7-Table_S7_Burden_testing_of_rare_exonic_and_UTR_variants_MAF_0_001_identified_in_45_SUD_cases_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
SLC27A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00485732
CRCGN011_HEPG2_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56905
PMC10714175-mmc2.xlsx-KD_Gene_list-Supplemental_Table_3_FAM13B_knockdown_mediated_changes_in_gene_expression_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CYP20A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00954472
BRD-K75775113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33522
GSE65617_5_v_3_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IL31	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00578449
TRPA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00810053
APEX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10194
Sunitinib	DeepCoverMOA Drug Mechanisms of Action	1.0	1.13
CRCGN015_MCF10A.WT.HP_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28725
Episodic ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.637
BRD-K19608864	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33513
CRCGN015_HEPG2_48H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2128
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9266
TAS1R2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00573163
GSE145311_1_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ASB13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0312
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
Cerebellum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
RAPGEF6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0117551
Dilated cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.116
dyclonine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.42516
SLC26A10P	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00771014
mhhnb11	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.725
HTRA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00675888
clopidol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99991
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.11624
OC-10-FB51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.594221
CRCGN015_MCF10A.TP53.M_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1576
HCRT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00559518
ICAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00339034
SPIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0423
HOXD12::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4148
CBX4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00672846
BRD-K27352194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41343
Slit diaphragm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.072
NCF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00676348
GSE169356_2_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RHOU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13722
AD-18-XC14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.335981
BRD-K11577431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51439
CRCGN011_HEPG2_24H:N11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0653
CLCNKB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0050281
LPAR5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00756458
HS746T	DepMap CRISPR Gene Dependency	1.0	3.89096
BRD-K01166365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09583
BRD-K48501991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52073
CXCL10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00718154
GSE151782_3_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229973_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4821877-ncomms10846-s9.xlsx-THP1_Splice_events-Gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
ALOX12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00583285
GSE116810_5_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5637904-PATH-243-193-s016.xlsx-human_up_in_fat_SOX11-Unnamed_6_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
ASIC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00770877
PTAFR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00479798
SLC36A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00599066
BC-61-ZY95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.252772
OAZ2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.015666
Cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.72
Dandy-Walker syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.258
CRCGN015_MCF10A.WT.HP_24H:F15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06944
PMS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14618
PDE6A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00613152
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PAM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0133952
BRD-K98140933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14409
BRD-K93337444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08886
GSE139016_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE115542_5_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Garland cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.354
BRD-K97666659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5811
GSE48812_8_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6303
GSE94849_7_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-18-MM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.637651
AKR1C1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00633183
GSE242290_1_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
BRD-K16554464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05938
GSE133213_11_v_13_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100327_PCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.78223
PMC11385366-Table2.xlsx-DBP-Overlapped_Gene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
Mitochondrial Encephalopathy	DisGeNET Gene-Disease Associations	1.0	null
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.547969
ERF::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7026
CRCGN015_MCF10A.TP53.M_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00206
GSE112860_5_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_0_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Respiratory chain complex IV	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.43
CRCGN016_MCF10A.WT.HP_24H:E22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0334
CRCGN015_MCF10A.TP53.M_24H:D15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68205
ABCA8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00706674
SIRPG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00901971
OSBPL6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00607734
MAPT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00684486
HDAC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00501863
BRD-K11030235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12157
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264986
increased susceptibility to pharmacologically induced seizures	MGI Mouse Phenotype Associations 2023	1.0	null
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.089
BRD-K66573697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37396
CRCGN015_MCF10A_48H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.92718
DGAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00749137
STAC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00509946
GSE144231_2_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K04365932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25484
GSE124410_6_v_5_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AF-83-BX08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336245
Granulocyte percentage of myeloid white cells	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.13979
CRCGN011_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3522
Neurodegenerative disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
PF-59-CY33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.323766
GSE135514_8_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257444
SLC22A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0186871
GSE111247_2_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0232
GSE197571_3_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Episodic ataxia type 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.096
BRD-K15350548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00174
GSE134191_3_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Mitochondrial encephalomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.24
G6PD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00829901
HIF3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00512106
BRD-K75915595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54779
10799_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.553567
PROP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.985
BD-94-KU93_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.324693
KCNQ5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0119974
MGRN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00555394
SLC25A6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00594692
BRD-K93460493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28445
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K83487481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6263
GSE149903_5_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RGCC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00805632
SLC29A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00564785
BRD-K56126872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73512
BRD-K41389177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12657
ALDH6A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.010451
PMC9019027-42003_2022_3332_MOESM3_ESM.xls-Table_S1_HUVEC_MED23-KD_DEGs-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242083,GSE242098_3_v_4_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SOCS5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00684835
HLA-DMB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00901426
ZNF766	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1734
GLS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0126698
Auditory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.725
pentolinium	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11538
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205316,GSE205317_0_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE60217_1_v_10_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.369335
AZIN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00681352
GSE178560_0_v_1_irf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BE-31-XV38_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285183
Nfe2l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.0055
Mitochondrial prohibitin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.929
GSE122101,GSE122103_0_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00579469
ESO51	DepMap CRISPR Gene Dependency	1.0	3.06143
GSE248045,GSE248046_6_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149903_0_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K28488100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37908
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UBOX5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00719618
OSM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00544334
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.76775
BRD-K05970499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43964
LY86	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00584596
GSE112860_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K78812892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02673
496100555_TCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.21301
BRD-K36848506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7206
MK2206	DeepCoverMOA Drug Mechanisms of Action	1.0	0.88
BRD-K06431655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02732
Alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
WDR36	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00599635
REG1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00592641
GSE128634,GSE128636_4_v_5_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Ensembl_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10534007-Table_3.xlsx-S3_unique_up_MSC_B_2-48_elements_included_exclusively_in_BFTC905_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE230744,GSE237803_5_v_3_hira_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.597
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HDGFL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00639913
CRCGN008_HEPG2_24H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.49715
RORC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9216
ALAS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00963186
GSE221327_10_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
CPNE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67432
IL23A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0167662
GSE203329_0_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9441
KANSL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00581997
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.610198
GSE133516_5_v_6_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K67632894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33358
DC-47-KV62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288456
GSE189653,GSE203344_2_v_0_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SLC1A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0150624
SUFU	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00869668
IL16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0107332
GSE210655_3_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.242
ESRRA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00480335
Seminal vesicle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CHPF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00975873
BRD-K97624648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07308
BRD-K00418890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76954
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CLEC12B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00932301
GSE113106_0_v_5_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PET complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.907
INPPL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00670785
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7606598-NIHMS1624889-supplement-1624889_Supp_Tab1-10.xlsx-S8_MR-JTI-genename_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE206729_2_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Machado-Joseph disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.373
IQSEC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00751332
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.458801
GSE114992,GSE114993_7_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K19862308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41527
BRD-K62781263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16215
GSE189789_0_v_1_oridonin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9288051-13046_2022_2428_MOESM4_ESM.xlsx-Super_enhancers_in_AML2-OVERLAP_GENES_RUNX3	Rummagene Transcription Factor Associations 2026	1.0	null
2121_DDX42_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.626201
GSE162739_7_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE225982_2_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135030_11_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K85456600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39298
Ataxia telangiectasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.428
Dysdiadochokinesis	DisGeNET Gene-Phenotype Associations	1.0	null
KDM4B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00685907
BRD-K84362145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22078
ESRRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.15
RRP15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00667003
TNNI3K	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00515604
LIG3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00577399
REPS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00494193
GSE48812_7_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE86507,GSE86509_3_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K61520618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22536
BRD-K80166820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72228
BRD-K13007223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53994
WDR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00724858
PRM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00569697
FNTB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0105683
EA-33-QC97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247264
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.93216
BRD-K56437119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0322
GSE218098,GSE218099_1_v_0_tcf19_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Primary coenzyme Q10 deficiency 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.479
PMC12456957-elife-100248-data2.xlsx-Genes_SP_0_6-ZNF706_ZNF706	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K99485242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95446
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.54088
Glycine encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.425
GSE149880_0_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198165,GSE198166_6_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE206729_4_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
APP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00584775
BRD-K27885385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09537
GSE48812_3_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.627747
BRD-K26161397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52205
GSE205316,GSE205317_0_v_1_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AA-70-DH87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271088
Neurodegeneration with brain iron accumulation 2a	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
ID2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00466733
GSE193999,GSE194000_3_v_2_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160373_8_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K69718434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01152
CRCGN011_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.93625
MAVER1	DepMap CRISPR Gene Dependency	1.0	2.15378
BRD-K15714104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03777
PLCE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00777215
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_2_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K90004516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44178
P2RY11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00789915
7734_SEC13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.05867
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30421
PPARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2579
GSE247230_0_v_1_anp32b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111061_1_v_0_tofacitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_15_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CCDC158	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00592934
SB 216763	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.86
GSE165122_2_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:B23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3504
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE199644_3_v_2_palmitic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195559_2_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PGAP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53896
SP110	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00705037
CRCGN015_HEPG2_48H:J03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.8721
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
PTGFR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00679562
DUOX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00772083
GSE48812_8_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Subthalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.661
GSE147210_3_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLC22A18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00543402
DA-07-LL18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.277936
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Gene_Name_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
HDAC8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00482409
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.718
GSE154767_2_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.484
AB-97-BI36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25125
TGIF2LY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3026
HOPX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0116413
TTBK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00576591
GSE147662_2_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:P09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4447
Metabolism	Reactome Pathways 2024	1.0	null
Combined oxidative phosphorylation deficiency 11	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.035
HOXB4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.847
GSE214596,GSE214598_1_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Blastocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.777
BRD-K62248885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55289
MICALL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00787955
STK17B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00437441
BA-68-FJ41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.295478
NCBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16482
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.506276
GSE184210_0_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MAP1LC3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00960886
INPP4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00574668
GSE158431_2_v_3_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE221327_8_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
Chloroplast stroma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.631
Muscular atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
GSE143643,GSE143644_1_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.48
TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GJD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00703477
A549_PF-3845_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134142
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
143B cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.43
CEACAM20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0067892
GSE185519_3_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.286
docebenone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42105
CCDC163	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04862
IL17D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00689836
CRCGN017_MCF10A.TP53.M_24H:B15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02061
GSE147662_3_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
D458	DepMap CRISPR Gene Dependency	1.0	10.2952
SLCO2B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0072402
GSE163297_0_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAST2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00553226
GSE202434,GSE202438_3_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.26171
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10257426-MOL2-17-1041-s007.xlsx-Pathways_geneset-HALLMARK_P53_PATHWAY_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
CB-44-RT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207815
CRCGN014_HEPG2_3H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4177
CRCGN015_MCF10A_48H:M11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.13386
DDIT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00359739
PHACTR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00659605
GSE212299_3_v_0_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0778
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN011_HEPG2_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65525
CCDC93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08324
Cauline leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.539
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_2-ETS1-bound_promoters_ETS1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE138789_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE137144_5_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K90127029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00493
Autosomal recessive ataxia due to ubiquinone deficiency	ClinVar Gene-Phenotype Associations 2025	1.0	null
BRD-K47618355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39797
BRD-K11504077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18224
Mitochondrial chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.017
impaired exercise endurance	MGI Mouse Phenotype Associations 2023	1.0	null
GSE182680,GSE182683_0_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HC-01-FD24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.88185
PTPN4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00616969
Plastid stroma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.58
BRD-K88739137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33269
Glutaric acidemia type 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.568
SIGLEC8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0143023
BRD-K50146114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13595
GSE201270,GSE201272_0_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:J03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0662
PMC11956947-media-4.xlsx-C_GSEA_gene_sets-HALLMARK_P53_PATHWAY_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
LTBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00536453
GSE103297_1_v_0_glis3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
phosphorylation	GO Biological Process Annotations 2025	1.0	null
GD-82-CS38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.494044
PMAIP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00452946
BRD-K37131263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09846
PMC10916575-ADVS-11-2306268-s001.xlsx-P53_PATHWAY-V2_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213442_1_v_0_kpna2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157594_0_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE197850_4_v_0_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FBXL19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00781512
BRD-K20184768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0804
GSE95077_5_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE184356_3_v_0_tfam_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.441
GCH1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.847
HCC1500_BREAST	CCLE Cell Line Proteomics	1.0	2.27422
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226249_5_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE246195,GSE246305_1_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TOP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00502109
BRD-K34318928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06411
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.708332
GSE213650_0_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE175787_8_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
NTRK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00672566
Metabolic acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.887
BRD-K78222058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47409
496100338_HIP_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.33501
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289413
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PBK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00667468
Pyruvate decarboxylase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.384
Organellar ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.324
anion binding	GO Molecular Function Annotations 2025	1.0	null
FOS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00531499
PDE3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00480334
PMC3807112-srep03041-s6.xls-E2F1-Gene_Symbol_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K75143842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.7177
DMPK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00682952
MRPS18A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00683422
PLXNB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00757022
Rosette leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.861
Alpers-Huttenlocher syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.535
Bone structure disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.105
HM13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00916832
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.518473
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_downregulated_genes-Unnamed_6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PPM1G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00484386
GSE157594_5_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11490525-414_2024_3265_MOESM3_ESM.xlsx-Table_S8-Table_S8_Burden_testing_of_rare_exonic_and_UTR_variants_MAF_0_001_identified_in_151_SIDS_cases_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE157594_6_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K09250623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74337
SHTN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00626457
SCN3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00586082
GSE232631_4_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K61020385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19983
Choreatic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.683
GSE234340_4_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
USP34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19467
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
GSE236504,GSE236505_0_v_1_atmin_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10231840-pcbi.1011118.s007.xlsx-Major_Cancer_Pathways-P53_Signaling_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
NELFA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00927685
BRD-K26709432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53134
GSE168807_0_v_8_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SIGLEC12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0075994
PMC11166884-mmc4.xlsx-Table_S3-Table_S3_proinflammatory-EC2_comparison_between_WT_and_TG_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
RBPJ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6045
GSE180277_0_v_1_bach2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NKX2-5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00771363
GSE226114,GSE226116_2_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SLC45A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0100542
IL9R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00633533
SPINK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0129771
BRD-K59445060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07711
GSE235390_4_v_0_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RASGRP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00671143
GSE114992,GSE114993_7_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224969,GSE224971_3_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K92312193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07911
CRCGN015_HEPG2_48H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.4661
KCNK12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00344615
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_4_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-49-NG46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244492
GSE198165,GSE198166_6_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K10459843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44883
Ubiquinone biosynthesis complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.474
Pearson syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.687
CRCGN011_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66905
PMC9882185-media-4.xlsx-Neuron_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Autosomal recessive spinocerebellar ataxia 8	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.844
CRCGN015_MCF10A_48H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.60544
GSE143662_3_v_1_dcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K90349877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97009
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.535838
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-mouse_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BA-84-TD72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.315794
Cerebellar nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.989
KMRC1	DepMap CRISPR Gene Dependency	1.0	3.42816
UNC119	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00568768
GSE166169_1_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSTO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00665093
Gut microbiota (bacterial taxa, hurdle binary method)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.522185
PRDM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0129483
BRD-K73678117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23502
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE158431_2_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K64811593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84449
ELL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00873319
CRCGN011_HEPG2_24H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10865
GSE180951_1_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.382176
EDN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00411165
GSE110268_0_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mean spheric corpuscular volume	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.91549
SKAP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00581644
BRD-A06232236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06214
abnormal Purkinje cell morphology	MGI Mouse Phenotype Associations 2023	1.0	null
CHRNA6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00654378
GSE165308_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PDK1-In	DeepCoverMOA Drug Mechanisms of Action	1.0	0.4
Lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.093
BA-68-FJ41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237704
GSE202434,GSE202438_13_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE171837_3_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41393
PMC7021759-41467_2020_14682_MOESM10_ESM.xlsx-upregulated_genes-Table_S7_Upregulated_genes_in_SKNMM_and_U2OS_cells_with_MYCN_induction_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3607232-mmc3.xlsx-b_RUNX1_SEM_MLLC_H3K4Me3-x_2_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GLRX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00792042
Ophthalmoplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.831
AADAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00775148
AE-19-BK71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.569279
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286979
PMC11391000-12672_2024_1303_MOESM5_ESM.xlsx-P53-x_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
OXGR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00462777
GSE145311_0_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Succinate dehydrogenase complex (ubiquinone)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.737
Hearing Impairment	DisGeNET Gene-Phenotype Associations	1.0	null
PAK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0061922
SMARCD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0119166
quinone biosynthetic process	GO Biological Process Annotations 2023	1.0	null
MREG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00546482
SHF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00611672
BRD-K36557327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27604
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.897426
Thorax	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC5058748-oncotarget-07-31177-s002.xlsx-ZNF224_gene_peaks_promoter-Table_S3_Genes_that_contain_a_ZNF224_enriched_region_within_1_kb_of_the_transcription_ZNF224	Rummagene Transcription Factor Associations 2026	1.0	null
Metabolism of vitamins and cofactors	Reactome Pathways 2024	1.0	null
PSG6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00800116
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.693153
Intramolecular phosphotransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.105
U-373MG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.571
GSE92589_0_v_1_sirolimus_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01486
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEp3_DN_NR2F1_ind_DN-NR2F1_Ind_DN_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
Hyperreflexia	DisGeNET Gene-Phenotype Associations	1.0	null
KCNA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0202383
GSE242083,GSE242098_3_v_5_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PTGDR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0115586
GSE112860_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203308_9_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26533
RSBN1L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00598904
RPS20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24937
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.603322
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.58009
Tricarboxylic acid cycle enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.045
RPL19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00738802
WARS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0128662
KDM3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00454324
CRCGN016_MCF10A.WT.HP_24H:N01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39751
GSE239688_4_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE189653,GSE203344_2_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-d-Classification_of_camel_SON_basal_genes_-_enzymes_SON	Rummagene Transcription Factor Associations 2026	1.0	null