association	dataset	threshold value	standardized value
HELQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14634
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
NFIC	JASPAR Predicted Transcription Factor Targets	1.0	null
orbital frontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.986509
GSE182179_2_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.98995
cognitive impairment	GWASdb SNP-Phenotype Associations	1.0	0.766703
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FOXD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.0465
MYC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97165
parkinsonism	GWASdb SNP-Phenotype Associations	1.0	0.942765
SCAMP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01865
MRPL20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8438
agranular insular cortex (area Iag)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.997403
GSE198165,GSE198166_0_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
type ii diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.782369
Lysosomal lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.74
DOT1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55636
ANP32D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11712
mRNA_ESX1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
PA-TU-8988S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.929872
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
KIAA0753	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38255
abnormality of neutrophils	GWASdb SNP-Phenotype Associations	1.0	0.383672
FOXA1_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11749115-loae020_suppl_Supplementary_Table_S2.xlsx-CHOP-high-gene_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
C15orf61	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95299
OTUD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06923
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CLPTM1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3875
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.719242
HNF4G	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2955
ERMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79057
orbital frontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.36249
GSE240386,GSE242143_8_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60566
HCC1806	CCLE Cell Line Gene Expression Profiles	1.0	1.50143
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
EGFL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09144
SEMA4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29305
496100561_PCx_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	5.56771
NCIH1339	CCLE Cell Line Gene CNV Profiles	1.0	1.51274
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.04163
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EJ-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202434,GSE202438_8_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03274
COLO680N	DepMap CRISPR Gene Dependency	1.0	14.3607
VZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.02583
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.904378
Pancreatic adenocarcinoma_PAAD_TCGA-US-A77G-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mafb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.4689
anterior (rostral) cingulate (medial prefrontal) cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.840209
Arx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.2777
GSE175787_13_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	-1.0	null
striatum_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.936904
Prion disease	KEGG Pathways 2026	1.0	null
POLI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35047
icSARA deltaORF6_30Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.64374
SLFN13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71959
FGF22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71699
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44225
HOXD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05563
JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.1422
POU2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1332
CREM	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1891
CREBZF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.65516
MLXIPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70456
BEND5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60247
RNF182	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38815
NKX6-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02165
abnormality of carbohydrate metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.214736
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.85603
Intercalated disc	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.7
ZNF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31327
mitochondrial part	GO Cellular Component Annotations 2015	1.0	null
CLDN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25381
PRMT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62194
Bladder Urothelial Carcinoma_BLCA_TCGA-MV-A51V-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TENM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39512
posterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.55546
Perturb_13035_KO_Eed_SRP152509	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.86009
Brain Lower Grade Glioma_LGG_TCGA-QH-A6XC-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE101336_1_v_2_decitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PAAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88394
Psoas major	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.637
Nasopharynx carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.138
ITCH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31202
central nervous system disease	GWASdb SNP-Disease Associations	1.0	0.21217
SREBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.2839
layer I of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.985302
Dlx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.1615
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.34339
Shox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.4554
abnormal neutrophil cell number	GWASdb SNP-Phenotype Associations	1.0	0.641745
TTLL8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47942
NUDT18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65701
heart	GTEx Tissue Gene Expression Profiles	-1.0	-1.01673
PPP3CB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49104
EID3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82615
envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GRHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3686
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34546
PRR15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24883
GSE120413,GSE120447_0_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lysosomal matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.892
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.03132
TFE3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.49
HCA1	DepMap CRISPR Gene Dependency	1.0	2.23656
breast	GTEx Tissue Gene Expression Profiles	1.0	0.990456
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16163
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CB-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Combined oxidative phosphorylation deficiency 12	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.136
prepositus hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11519
ZRANB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54555
Brain Lower Grade Glioma_LGG_TCGA-S9-A6U5-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRIM32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13128
Prdm15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.1945
UNC13B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74371
laterodorsal subdivision of area 8	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14468
HCC827GR5	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.09864
parkinson's disease	GWASdb SNP-Disease Associations	1.0	1.07599
UBTF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1852
BT-483	COSMIC Cell Line Gene Mutation Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12498
SK-BR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.82303
single-organism transport	GO Biological Process Annotations 2015	1.0	null
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.954507
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IH-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Atf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.5584
H3C14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50218
HEL	CCLE Cell Line Gene Expression Profiles	-1.0	-1.77008
SKMM2	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.04572
PDXP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2125
B4GALNT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94054
CEP95	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78202
LIG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29009
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
EFO21	Achilles Cell Line Gene Essentiality Profiles	1.0	3.19303
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Respiratory chain complex IV	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.383
fenofibrate_homo sapiens_gpl4044_gse15494	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.227611
primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34152
Morula cell (Blastomere)_Embryo_Human	CellMarker Gene-Cell Type Associations	1.0	null
USP32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69597
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.890848
GFPT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44816
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XP-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZC3H12D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61274
CRB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29215
CERK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13949
MBLAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02101
RAB7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52072
SOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.99377
Adrenocortical carcinoma_ACC_TCGA-OR-A5JV-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HEP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.929872
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.774598
ZNF626	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07412
ZC3HAV1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3532
biological_process	GO Biological Process Annotations 2015	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-MI-A75I-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CXXC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19571
organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
indusium griseum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.86359
cellular process	GO Biological Process Annotations 2015	1.0	null
GSE202434,GSE202438_9_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A6S3-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NEUROD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01735
SHLD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24847
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44093
ARFGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9055
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TI-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH2405	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40041
Lung adenocarcinoma_LUAD_TCGA-35-4122-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUM 149PT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.27131
lateral subdivision of area 9	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.9056
TIMM17A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0672
LHX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45208
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YU-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE145639_7_v_4_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_15_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
APBA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80241
496100333_FWM_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.87944
SLTM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08757
BHLHA9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53005
FOXL1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
HDQP1	CCLE Cell Line Gene Expression Profiles	-1.0	-3.14432
GSE119978,GSE180930_0_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.876
SMAD4-21741376-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.28587
transporter activity	GO Molecular Function Annotations 2015	1.0	null
hippocampus (hippocampal formation)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.13398
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.477
ZNF582	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.256
HOXC13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9858
TRAPPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99229
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01226
ZNF564	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84123
inner CP in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29726
COLO205	Achilles Cell Line Gene Essentiality Profiles	1.0	1.09457
Brain Lower Grade Glioma_LGG_TCGA-S9-A7QY-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMAD4	ChEA Transcription Factor Targets	1.0	null
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040528
PK-45P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14994
FOXO3_01_267	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61625
GSE206516,GSE206518_0_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ASNSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66937
Elf5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.0823
Lung adenocarcinoma_LUAD_TCGA-49-6743-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10794186-41598_2024_51947_MOESM16_ESM.xlsx-Supplementary_Table_14_Shared-Supplementary_Table_14_Shared_genes_between_Gong_et_al_clusters_and_SOX9-AS1_regulated_genes_SOX9	Rummagene Transcription Factor Associations 2026	1.0	null
SKMEL1	CCLE Cell Line Gene CNV Profiles	1.0	2.68358
Lung adenocarcinoma_LUAD_TCGA-62-A471-01A-12R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4844
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1043
Brain Lower Grade Glioma_LGG_TCGA-FG-A711-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE193258,GSE193259_9_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SEMA4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23244
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.25611
BHLHE41	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.619
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SW 900	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01078
HSPB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34596
transport	GO Biological Process Annotations 2015	1.0	null
BLVRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23234
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
abnormality of granulocytes	GWASdb SNP-Phenotype Associations	1.0	0.300713
ISG20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61431
Perturb_13037_KO_Pcgf1/Pcgf6_SRP269225	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.10584
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Diabetic cardiomyopathy	KEGG Pathways 2026	1.0	null
NCIH1299	CCLE Cell Line Gene CNV Profiles	1.0	2.84872
TMEM131L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65995
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RJ-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4770-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LARP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45171
RETREG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75341
Pancreatic adenocarcinoma_PAAD_TCGA-RB-A7B8-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ESR1_KD_GDS4061_453_human_MCF7 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE240439_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-KR-A7K7-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A20B-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.84959
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34417
496100305_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.92023
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.622443
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
establishment of localization	GO Biological Process Annotations 2015	1.0	null
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03066
Pilomyxoid astrocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
spinal (inferior) vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.32513
Perturb_6299_KD_CGA_SRP355115	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
FOS	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9482
Lung squamous cell carcinoma_LUSC_TCGA-46-3769-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Paramyotonia congenita of Von Eulenburg	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.531
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A5-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4427-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
specific learning disability	GWASdb SNP-Phenotype Associations	1.0	0.766703
SCG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67403
Mesothelioma_MESO_TCGA-TS-A7PB-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.880443
JIMT-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.33742
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VASH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57152
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.87189
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1AC-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-5779-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
EVI1-22308434-SKOV3-HUMAN-OVARY-OVARIANCANCER	ChEA Transcription Factor Targets 2022	1.0	null
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.956608
GSE211224_2_v_1_donepezil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
posteroventral (inferior) parietal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.28587
HEP3B217	CCLE Cell Line Gene CNV Profiles	1.0	1.65207
Liver hepatocellular carcinoma_LIHC_TCGA-QA-A7B7-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBX15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91655
CBX2-27304074-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
KCNF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.58051
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.85457
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1491
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1A7-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU5F1_01_05	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59676
PARP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25395
GSE132948,GSE132949_2_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NAGLU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24471
WBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21654
PSMD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32488
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
A-431	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10167
GSE145639_1_v_2_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CCAR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31643
VWA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74649
ATF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77652
CNMD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02791
Cognitive decline (age-related)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.630103
SOX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94505
ARPC1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42862
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.888673
Amyotrophic lateral sclerosis	KEGG Pathways 2026	1.0	null
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.865855
L3MBTL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7246
GSE193258,GSE193259_2_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
molecular layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.51392
H4C13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79487
GSE172016_2_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GNPTG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34646
KYSE-450	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NIHOVCAR3	DepMap CRISPR Gene Dependency	1.0	4.15047
KAT6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59639
PMC9530161-41419_2022_5296_MOESM2_ESM.xlsx-Tab10_KDM5C-KD-up-DKD-rescued-Table_10_Up-regulated_genes_in_KDM5C-KD_and_rescued_genes_in_DKD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE240027,GSE240030_1_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OTX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9067
PMC4259449__F5	PFOCR Pathway Figure Associations 2023	1.0	null
UBN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23788
GSE238018_3_v_0_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ARH77	DepMap CRISPR Gene Dependency	1.0	3.33473
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
ARF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56127
PMC10273062-JCMM-27-1708-s001.xlsx-Sheet_1-BRCA_AND_UCEC_NOT_CESC_NOT_UCS_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
UV-sensitive syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.548
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.95185
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7X1-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
impaired fertilization	MGI Mouse Phenotype Associations 2023	1.0	null
GSE242367_1_v_0_dpp9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Adenoid cystic carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.623
Water	HMDB Metabolites of Enzymes	1.0	null
GSE193258,GSE193259_5_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
B4GALT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51999
PMM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80291
PHF20L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40485
NR6A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.15296
CFP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69619
ZSCAN23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28891
MPP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20856
C1orf56	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67029
SH2D5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6301
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.4941
TNFSF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81752
LSM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80479
language disorder	GWASdb SNP-Disease Associations	1.0	0.873424
magnocellular division of VA	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.40514
KCNJ11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.24272
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20567
HDGFL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30705
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.27131
GSE173169,GSE173170_0_v_1_epc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
mitochondrial envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9827
ZNF777	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3612
L33	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.09483
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.60359
SHP77	DepMap CRISPR Gene Dependency	1.0	2.97385
GSE112761,GSE112767_4_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59862
OPM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03129
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A495-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KHM1B	CCLE Cell Line Gene Expression Profiles	1.0	1.67626
FOSL2::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.292
22RV1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TCF7L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05123
K029AX	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36909
single-organism process	GO Biological Process Annotations 2015	1.0	null
GSE198380_0_v_1_phgdh_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193258,GSE193259_5_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31563
PRRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82262
CTTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33109
Rectum adenocarcinoma_READ_TCGA-EI-6513-01A-21R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE125011_0_v_2_cd83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MEF2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5046
H2AZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70368
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7069-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NEURL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86636
mRNA_ZSCAN4C_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE88819_1_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC48A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17293
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04402
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51N-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hydrogen transport	GO Biological Process Annotations 2015	1.0	null
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2165
COPE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87667
PCDHB13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76513
SHOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15622
GCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88654
GSE183101_0_v_1_hvcn1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3I3-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C11orf86	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45681
JHH-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LN319	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.95814
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
SK-MEL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.19301
Brain Lower Grade Glioma_LGG_TCGA-HT-8105-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
basomedial nucleus (accessory basal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08448
PMC9314667-Table_1.xlsx-Regulons-ETV4_ETV4	Rummagene Transcription Factor Associations 2026	1.0	null
ISL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3227
DICER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14569
NKX3-2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25469
MZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.991955
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CA-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16013
caudal putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.864402
Irf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	70.1439
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.44067
synucleinopathy	GWASdb SNP-Disease Associations	1.0	1.07599
Variegate porphyria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.539
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.10226
THEM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72522
GSE130396_7_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5
LGALSL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57105
TLCD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41366
SMUG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68887
neurodegenerative disease	GWASdb SNP-Disease Associations	1.0	0.333975
inner CP in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.37931
GSE88819_6_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
PMC12769604-13402_2025_1147_MOESM6_ESM.xlsx-Table_S4_3_Venn-Scissor_AND_Tumor_NOT_Prognosis_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
SKLU1	CCLE Cell Line Gene CNV Profiles	1.0	1.40534
FOSL2::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.002
IRX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97114
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H2-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ACP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74467
short attention span	GWASdb SNP-Phenotype Associations	1.0	0.557335
CACNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86941
PCSK1N	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92717
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81R-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PECAPJ49	CCLE Cell Line Gene Expression Profiles	1.0	1.37113
PRKCSH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78487
PTPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64978
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03274
GSE95685_4_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GS-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02806
oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	GO Molecular Function Annotations 2015	1.0	null
CD63	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49011
SIN3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59345
posteroventral (inferior) parietal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.834644
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JA-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KP3	CCLE Cell Line Gene CNV Profiles	1.0	1.73573
CLCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72177
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.865855
ATAD2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51082
ARHGDIA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99349
Alpers-Huttenlocher syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.323
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.59976
PSS008	DepMap CRISPR Gene Dependency	1.0	2.2525
GSE87862_0_v_1_mov10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LSM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15465
GSE137954_4_v_2_smyd3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4494-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KYSE220	DepMap CRISPR Gene Dependency	1.0	3.99069
FEZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73834
anteromedial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.57758
methylcrotonoyl-CoA carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.922
ZFP28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79605
evolutionarily	GeneRIF Biological Term Annotations	1.0	null
GSK3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48169
ZBTB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.02947
inner SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19074
PSMF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27159
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A1OC-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MKN45	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35129
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41R-01A-21R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE169356_2_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LS123	CCLE Cell Line Gene CNV Profiles	-1.0	-2.03694
amygdaloid complex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12405
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3455-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POGLUT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26761
Pancreatic adenocarcinoma_PAAD_TCGA-OE-A75W-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.4068
EIF2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02647
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.592962
ERBB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2685
pituitary	GTEx Tissue Gene Expression Profiles	1.0	1.4084
paravermis of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28388
eye disease	GWASdb SNP-Disease Associations	1.0	0.092963
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZQ-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1A3-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.258
ACBD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00683
Pancreatic adenocarcinoma_PAAD_TCGA-FB-A78T-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SKCO1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.94664
PNPLA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01115
TMEM267	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29147
TMEM134	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30439
anterior (rostral) cingulate (medial prefrontal) cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02066
RAD9A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27453
MFE296	DepMap CRISPR Gene Dependency	1.0	5.71853
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.8652
NR5A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67849
GATA3	ENCODE Transcription Factor Targets	1.0	null
outer SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22409
LRRFIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61744
Nfat5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.1938
TPRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19783
PTX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62561
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WFIKKN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52593
SLC39A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07305
DIPK1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9295
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1085
KLHDC8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55611
GSE242367_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary motor-sensory cortex (samples)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.860194
Adrenocortical carcinoma_ACC_TCGA-OR-A5KX-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsal thalamus_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09081
ACAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74478
RAB11FIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30184
GSE97278,GSE97280_2_v_1_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SRF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C2CD2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51731
HSF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25904
Skin	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.50763
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CAOV3	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
Brain Lower Grade Glioma_LGG_TCGA-F6-A8O3-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-ensembl_AR	Rummagene Transcription Factor Associations 2026	1.0	null
OGDHL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.757
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8249
AEBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5729
PCM6	CCLE Cell Line Gene Expression Profiles	1.0	3.40752
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.462619
TADA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83335
KHM-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32918
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04402
SSRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92718
eye and adnexa disease	GWASdb SNP-Disease Associations	1.0	0.092963
PMC6639357-41467_2019_11150_MOESM4_ESM.xlsx-SupTab1_Activated_genes_diffex-Supplementary_Data_1_Fold_change_and_p-value_of_all_activated_protein_coding_genes_upon_DNMT1-KO_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
PIP4P2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55512
VIPAS39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30656
FHL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26441
MATN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07547
UBA52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03659
SP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.95326
GSE196259_2_v_3_gcm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RHNO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33069
RYBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83938
electron carrier activity	GO Molecular Function Annotations 2015	1.0	null
Type 1 diabetes mellitus_T lymphocyte_GSE10586	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.68203
GSE169205_3_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
LASV_FML29_24hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	0.735473
Brain Lower Grade Glioma_LGG_TCGA-DU-6393-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE101537_1_v_3_neurog3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MLX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2605
STEAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79738
SNU761	CCLE Cell Line Gene CNV Profiles	1.0	2.36041
HMGN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05843
ZNF124	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75582
PDCD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.0363
cerebellum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.875582
migraine	GWASdb SNP-Phenotype Associations	1.0	0.868241
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
17910759-TableS5	GeneSigDB Published Gene Signatures	1.0	null
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-RY-A840-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
inorganic cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RG-A7D4-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PAK1IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97385
all	GWASdb SNP-Phenotype Associations	1.0	0.061256
FOXE1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	161.415
FIZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.941
TMBIM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19775
Spermatoproteasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.873
icSARS CoV_30Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.73258
fallopian tube	GTEx Tissue Gene Expression Profiles	-1.0	-2.10021
MARVELD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19434
RNF112	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23301
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.05392
STAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43007
FOSL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9795
UGCG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82489
GSE193258,GSE193259_5_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Homodimeric serine palmitoyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.883
BARHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.106
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.4137
CENPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73286
ZNF217_OE_GDS4885_317_human_MDA-MB-231 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WI-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.892868
TCF4-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
amygdaloid complex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.58633
Alx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.0594
KAT2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1603
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WL-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE195663_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CSNK1G2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51519
refractive error	GWASdb SNP-Disease Associations	1.0	0.397789
SHKBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28904
polymorphic layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.68711
SPAG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46281
Nasopharyngeal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
CCNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05601
CDCA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39502
RNF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81902
PMC10558344-mmc1.docx-3-ZNF670_ZNF670	Rummagene Transcription Factor Associations 2026	1.0	null
CFAP410	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96454
WDR73	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26411
NSMCE4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28146
GRAMD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66803
brain disease	GWASdb SNP-Disease Associations	1.0	0.18692
PMC4269325-NIHMS634665-supplement-supp_table4.xls-H3K27me3_TRIM37_KD-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A4MT-02A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5716
DDX53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27041
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MD-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DOK	DepMap CRISPR Gene Dependency	1.0	5.33527
Thyroid gland anaplastic carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
SRXN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.17285
AIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97073
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TK-01A-42R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE240386,GSE242143_1_v_4_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
mitochondrial inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Prostate adenocarcinoma_PRAD_TCGA-G9-6369-01A-21R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal leukocyte count	GWASdb SNP-Phenotype Associations	1.0	0.383672
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A5W6-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040353
Kidney renal clear cell carcinoma_KIRC_TCGA-AS-3777-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EXOC3L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49826
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	3.28423
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.85117
GLCCI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58724
alcohol abuse	GWASdb SNP-Disease Associations	1.0	0.719267
JHESOAD1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.8213
NTERA2CLD1	DepMap CRISPR Gene Dependency	1.0	6.74478
CDX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6539
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of myeloid leukocytes	GWASdb SNP-Phenotype Associations	1.0	0.2004
TES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16584
496100619_HIP_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.88515
Brain Lower Grade Glioma_LGG_TCGA-HT-7681-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TP53_01_286	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	4.05242
GSE233112_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UBE2S	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00151
TC138	DepMap CRISPR Gene Dependency	1.0	2.03797
Perturb_4607_KD_H2A.Z_SRP345495	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.65251
MGAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95382
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A69H-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
1321N1	CCLE Cell Line Gene Expression Profiles	1.0	1.42904
ST6GALNAC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05547
SMAD4-21741376-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05906
MASTL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43213
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0534
Lung adenocarcinoma_LUAD_TCGA-38-4631-01A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE240386,GSE242143_1_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE95077_1_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58137
BT549	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.0408
anterior (rostral) cingulate (medial prefrontal) cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.225
SNRPB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13258
SNU46	CCLE Cell Line Gene CNV Profiles	1.0	1.74509
DIDO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77842
TGFB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39417
SNU16	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50196
APIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73086
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
hsa-miR-520f	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
abnormal eye physiology	GWASdb SNP-Phenotype Associations	1.0	0.17851
ATG4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.443
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.880443
RARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0512
inorganic ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
PWWP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7444
ING5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94687
IRF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11256
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Medroxyprogesterone acetate_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0221239
NCIH2023	CCLE Cell Line Gene Expression Profiles	1.0	1.51781
GSE94814_2_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
substance-related disorder	GWASdb SNP-Disease Associations	1.0	0.251476
OSER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39416
Brain Lower Grade Glioma_LGG_TCGA-S9-A7R3-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6781638__F4	PFOCR Pathway Figure Associations 2024	1.0	null
behavioral abnormality	GWASdb SNP-Phenotype Associations	1.0	0.102576
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.40471
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27867
LEFTY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49751
GSE165274_1_v_2_poldip2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DLGAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43227
U2OS	CCLE Cell Line Gene Expression Profiles	-1.0	-1.64463
GALNT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8805
FAM210B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97157
nasopharynx carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.788033
POLR2A	ENCODE Transcription Factor Targets	1.0	null
medial subdivision of area 10	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.17156
hyperactivity	GWASdb SNP-Phenotype Associations	1.0	0.557335
GART	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49183
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.358
DYNLL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49745
A-VN-1203-2004(H5N1)_Day7-10^2pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.68722
GSE130396_8_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
membrane part	GO Cellular Component Annotations 2015	1.0	null
NRSN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07431
SORT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2903
NCI-H2722	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15922
3-methylcrotonyl-CoA carboxylase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.079
PPP1R26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30015
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.30394
RAB5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48927
NUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7888
znf217_22593193_mda_mb_231_gof_human_gpl570_gse35511	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.2162
migraine	GWASdb SNP-Disease Associations	1.0	0.986376
Lung squamous cell carcinoma_LUSC_TCGA-39-5039-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNAPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52218
CHD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06491
mRNA_EOMES_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
FOSB::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3844
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TG-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TMEM8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.42162
dyslexia	GWASdb SNP-Phenotype Associations	1.0	0.766703
Gitter cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.006
NCIH226	DepMap CRISPR Gene Dependency	1.0	7.04913
Heteromeric SMAD protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.406
Foxo1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.1367
Rarg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	56.5448
prostate cancer	GAD Gene-Disease Associations	1.0	null
G61	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.865855
inferior olive, principal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.41257
IFI6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23465
DB-34-QA60_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289727
disease	GWASdb SNP-Disease Associations	1.0	0.07061
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EJ-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-80-5611-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
medial superior olive	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.943437
MFHAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46759
LRRC58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94224
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15922
F2RL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36343
DB	CCLE Cell Line Gene Expression Profiles	-1.0	-1.51979
asthenozoospermia	MGI Mouse Phenotype Associations 2023	1.0	null
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.668
GSE162688_1_v_2_pink1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
heme-copper terminal oxidase activity	GO Molecular Function Annotations 2015	1.0	null
HCC1954	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.816527
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.985321
Lung adenocarcinoma_LUAD_TCGA-69-8255-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW 1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.880443
KHM1B	CCLE Cell Line Gene CNV Profiles	-1.0	-1.77783
monovalent inorganic cation transport	GO Biological Process Annotations 2015	1.0	null
PPDPF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03801
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE217156_2_v_3_trpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TTC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9452
skin	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.9092
ETAA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51151
PEX13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12123
Prostate adenocarcinoma_PRAD_TCGA-KK-A59Z-01A-12R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PYGB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84002
Non-alcoholic fatty liver disease	KEGG Pathways 2026	1.0	null
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
THP1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.87179
PMC10824666-43018_2023_699_MOESM2_ESM.xls-Suppl_Table_S4-AM-1882_AUC_vs_Gene_Expression_PRISM_Breast_and_Ovarian_Cancer_Cell_lines_n_58_PRDM6	Rummagene Transcription Factor Associations 2026	1.0	null
MARCHF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91765
CHRNA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.705
CITED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64327
VZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04917
Msx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.6579
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.250937
GSE217452_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
CEBPE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47669
ZR75B	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.768029
proton-transporting two-sector ATPase complex, proton-transporting domain	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.179
cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
ZXDB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3922
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Gene_Name_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
ATF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6654
mitochondrial membrane part	GO Cellular Component Annotations 2015	1.0	null
C2orf15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92296
OSBPL8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5914
localization	GO Biological Process Annotations 2015	1.0	null
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59491
GSE238018_3_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mesothelioma_MESO_TCGA-TS-A7P8-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.2955
EHMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92291
22RV1	DepMap CRISPR Gene Dependency	1.0	3.61721
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PAIP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71823
U138MG	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55659
STRN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57663
diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.350187
Carotid body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.884
FSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89137
JIMT1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.84752
oculomotor nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.967313
HCT116	DepMap CRISPR Gene Dependency	1.0	9.76201
CAS1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.17478
ARRDC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7842
CTAGE9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42332
SPRYD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43304
CAOV-3	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.83684
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
RARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8696
DANG	CCLE Cell Line Gene Expression Profiles	-1.0	-2.0818
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
MDAMB175VII	CCLE Cell Line Gene Expression Profiles	-1.0	-2.03093
DUSP26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56904
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Hmx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.7137
GARIN1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0548
GFUS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30239
CERS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49463
substance dependence	GWASdb SNP-Disease Associations	1.0	0.251476
HOXD9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.0848
anterior amygdaloid area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14193
inner CP in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17365
abnormal sperm midpiece morphology	MGI Mouse Phenotype Associations 2023	1.0	null
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.34058
496100510_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	5.41675
KYSE-510	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41534
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-4778-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Psoriasis vulgaris_Skin tissue_GSE14905	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.37327
ANKRD52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45422
CHSY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47385
FHIP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46976
HLE	CCLE Cell Line Gene Expression Profiles	1.0	1.98166
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03129
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GB-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.01905
HUH28	CCLE Cell Line Gene Expression Profiles	1.0	1.95355
SKOV3	CCLE Cell Line Gene Expression Profiles	1.0	2.26585
HCC1438	CCLE Cell Line Gene Expression Profiles	1.0	2.13658
Jun	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.5422
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.890057
HS729	CCLE Cell Line Gene CNV Profiles	1.0	1.51402
HT-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
JHOM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.79334
WDR89	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19429
language impairment	GWASdb SNP-Phenotype Associations	1.0	0.766703
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7888-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A4R8-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RBAK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67965
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.54237
outer CP in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.928982
TUFT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51092
EC-GI-10	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.83684
leukopenia	GWASdb SNP-Phenotype Associations	1.0	0.641745
GSE154936_3_v_2_remdesivir_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76532
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.345
GSE166783_0_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
NRIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17335
IKZF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68904
BACH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6025
MDAMB453	Achilles Cell Line Gene Essentiality Profiles	1.0	1.62491
NCIN87	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38242
Lung squamous cell carcinoma_LUSC_TCGA-77-8144-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
integument	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
LYN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74192
LOX-1_OE_GDS4262_434_human_HAECT - aortic endothelial cell line - 12 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.865855
Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KT-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE240027,GSE240030_1_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mitochondrion	LOCATE Predicted Protein Localization Annotations	1.0	null
LENG9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37492
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3X1-01A-12R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.42887
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.3068
LGALS3BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87177
SNU423	CCLE Cell Line Gene Expression Profiles	1.0	1.74916
CDO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.48134
RFXAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47476
SPHK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99853
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.985205
8MGBA	CCLE Cell Line Gene Expression Profiles	1.0	1.81715
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E8-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LRRC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23599
TT	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33087
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.910434
outer SZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.97788
GSE235701,GSE261434_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CMIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16478
ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
HOXD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25644
BCKDHA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41875
CAOV3	Achilles Cell Line Gene Essentiality Profiles	1.0	1.08486
TCF4	ChEA Transcription Factor Targets	1.0	null
mitochondrial respiratory chain	GO Cellular Component Annotations 2015	1.0	null
HCC95	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68721
USF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2688
TSPAN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.96924
Dmrt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.0996
POU2F3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.24261
ZKSCAN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19318
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.78092
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6297
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.910434
orbital frontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37642
RRBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98689
GSE222758_0_v_3_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
conserved	GeneRIF Biological Term Annotations	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE198165,GSE198166_9_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.52057
hematopoietic system disease	GWASdb SNP-Disease Associations	1.0	0.109561
ZDBF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61645
NHLRC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74806
mitochondrion	LOCATE Curated Protein Localization Annotations	1.0	null
SCC-25	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26835
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
TMEM205	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98597
SNU1105	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50305
primary auditory cortex (core)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37223
SJSA1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.88708
Brain Lower Grade Glioma_LGG_TCGA-QH-A65V-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTF3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90221
ETV1_01_161	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.97637
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE240027,GSE240030_1_v_0_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
corpus callosum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05806
leukopenia	GWASdb SNP-Disease Associations	1.0	0.38102
agranulocytosis	GWASdb SNP-Disease Associations	1.0	0.742812
SMAD3-21741376-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
monovalent inorganic cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
DPY30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28789
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.054237
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
PDPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77849
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125403_3_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08112
USP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0381
ARL6IP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53387
Brain Lower Grade Glioma_LGG_TCGA-DU-6400-01A-12R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1648	CCLE Cell Line Gene Expression Profiles	-1.0	-1.62173
primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.963
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WR-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PODXL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94225
METTL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.162
IZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.870646
c-MYC_KD_GDS2526_110_human_BT-474 BREAST CANCER cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ZNF410	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.2058
VPS33B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03458
RAP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95518
MOGGUVW	DepMap CRISPR Gene Dependency	1.0	2.83134
FBXO45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77553
TADA2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40553
MYBL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9626
496100580_PCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.50775
Stat2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	76.4898
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7673
Breast Cancer_Mammary Gland Tissue_GSE3744	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.40255
CAPAN1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.75914
OSBPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74484
PDXDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5207
SPATA33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.65692
ERO1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35691
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
IQGAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46925
LRRCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89738
UBA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3408
oxidoreductase activity, acting on a heme group of donors	GO Molecular Function Annotations 2015	1.0	null
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
DOCK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41912
inner CP in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.879299
C19orf47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3997
Oxidative phosphorylation	KEGG Pathways 2026	1.0	null
ZNF764	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32727
IZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.933673
lateral habenular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14986
inorganic cation transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_15_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A6X5-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HT	CCLE Cell Line Gene CNV Profiles	-1.0	-1.70372
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25S-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REXO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63354
abnormality of leukocytes	GWASdb SNP-Phenotype Associations	1.0	0.179556
NCI-H2066	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCCRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95105
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RAB42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43168
GSE202434,GSE202438_9_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF324	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1335
TBC1D13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41185
GSE206516,GSE206518_1_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
respiratory chain	GO Cellular Component Annotations 2015	1.0	null
COX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85333
rostral division of VL	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.883553
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.227
PRMT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94588
Chemical carcinogenesis - reactive oxygen species	KEGG Pathways 2026	1.0	null
GSE214823,GSE214824_6_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NUDT4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22283
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HC-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.873558
GSE210662_2_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	1.0	null
NO11	DepMap CRISPR Gene Dependency	1.0	2.3202
ES8	DepMap CRISPR Gene Dependency	1.0	2.93454
TFCP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8827
alcohol dependence	GWASdb SNP-Disease Associations	1.0	0.719267
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
IFNAR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30471
primary motor cortex (area M1, area 4)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24956
GSE79572_0_v_1_pax8_human	RummaGEO Gene Perturbation Signatures	1.0	null
PELP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90393
Lung squamous cell carcinoma_LUSC_TCGA-18-3406-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1725
DBF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11854
primary motor cortex (area M1, area 4)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.83397
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8567
ELL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74334
ZNF491	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11643
respiratory chain	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03954
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
cytoplasmic part	LOCATE Curated Protein Localization Annotations	1.0	null
GSE95077_5_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169697,GSE169725_0_v_5_prrx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mRNA_MYC_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H0-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostatic Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
SUPV3L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24693
PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.825151
RPS15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40092
NR2C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7969
mitochondrial membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
inner SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09162
HES5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89607
Ar	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.8376
ESX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64955
KDELR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58584
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
MAPK14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51023
PLEKHO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02996
ATP6V0A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07681
abnormality of movement	GWASdb SNP-Phenotype Associations	1.0	0.289268
GSE149035_2_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MIXL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31527
PMC7603494-41467_2020_19353_MOESM6_ESM.xlsx-Ch_TCF3_up_and_binding_Overlapp-Unnamed_6_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
KISS1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06481
SBNO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37814
MCM9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34846
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A681-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Six4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.6553
HSCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18912
VZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.960466
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
deep layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.3286
496100348_TCx_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.81219
USF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2339
KP2	Achilles Cell Line Gene Essentiality Profiles	1.0	1.45798
TFRC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24084
cell part	GO Cellular Component Annotations 2015	1.0	null
TM31	CCLE Cell Line Gene CNV Profiles	1.0	2.00457
Fanconi anemia complementation group A	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.606
GAMG	CCLE Cell Line Gene CNV Profiles	1.0	1.35072
cancer	GAD High Level Gene-Disease Associations	1.0	0.293278
Brain Lower Grade Glioma_LGG_TCGA-DB-5281-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZSCAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21747
mRNA_T_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
NCIH2172	CCLE Cell Line Gene Expression Profiles	1.0	1.4556
GSE222445_2_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GATA3_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU410	CCLE Cell Line Gene CNV Profiles	-1.0	-2.02844
SKMEL2	CCLE Cell Line Gene Expression Profiles	1.0	1.55877
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.7949
ZNF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98484
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
CASC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92679
Lung adenocarcinoma_LUAD_TCGA-97-8179-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EEF1B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47438
SCRN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25042
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7915-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OVCAR8	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.15917
layer IIIu of area 35r	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11481
PMC9376070-41419_2022_5157_MOESM18_ESM.xlsx-Sheet1-Table_S4_Differentially_expressed_genes_of_HNRNPC-KD_and_NC_cells_identified_in_the_RNA-seq_analysis_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Primary B cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.99145
NMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.23488
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
OBSCN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2021
NR1D1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.4501
GLUD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10469
SUM 229PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.10226
CPHXL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63257
primary motor-sensory cortex (samples)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.26702
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
layer II of piriform cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.951883
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
IAH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41639
ATF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45564
NCI-H2461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.85815
GSC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95975
RAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17238
PIK3R3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05113
SV2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83334
POGK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17246
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE145639_1_v_6_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7607
orbital frontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.63012
SLC38A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64104
HCE4	DepMap CRISPR Gene Dependency	1.0	6.35033
mitochondrial membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
FLI1-21867929-CD8-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Esophagus - Gastroesophageal Junction	GTEx Tissue Gene Expression Profiles 2023	1.0	7.21238
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A623-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOS::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3226
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A731-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100558_PCx_probable Alzheimer's disease_TBI_82_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.38074
DHCR7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31981
RBM11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9902
Perturb_15011_KO_Eed/Xist_SRP365240	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
ZBTB17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34667
substrate-specific transporter activity	GO Molecular Function Annotations 2015	1.0	null
PHLDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88702
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.929872
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.890057
PAPOLG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07098
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.865855
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
ZNF613	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6479
HCC1500	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.17347
SW1990	DepMap CRISPR Gene Dependency	1.0	4.55607
ZNF14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33804
AKAP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82477
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
inner CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27615
HDLM2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53223
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_ALL-GENE_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
STK17B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15332
specific developmental disorder	GWASdb SNP-Disease Associations	1.0	0.406712
LRRC4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19367
MTA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73974
GUF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57822
KHDC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41985
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MT-ATP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31003
inner CP in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.68255
ABL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20406
MITF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4247
Lung adenocarcinoma_LUAD_TCGA-MP-A4TA-01A-21R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCFCP2L1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PL45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.954507
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TV-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HARBI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55987
ITPRIPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26036
TRAF3IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79478
GATA3-21867929-TH1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
DIRAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30832
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TT-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.177666
NDUFB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40595
EFE184	CCLE Cell Line Gene Expression Profiles	-1.0	-2.01235
Liver hepatocellular carcinoma_LIHC_TCGA-BD-A2L6-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LOX-1_OE_GDS4262_433_human_HAECT - aortic endothelial cell line - 6 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
KYSE510	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.83808
Pancreatic adenocarcinoma_PAAD_TCGA-LB-A8F3-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PEX26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5127
PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TBC1D25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76973
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IB-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-5774-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32199
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.951548
NCI-H2126	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.880443
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Nearest_Ensembl_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
NCBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95517
GSE169205_3_v_8_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ONCODG1	CCLE Cell Line Gene Expression Profiles	1.0	1.83095
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.941287
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39V-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SARAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76214
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
CDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4152
LN235	DepMap CRISPR Gene Dependency	1.0	2.2199
ORC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92685
abnormality of the eye	GWASdb SNP-Phenotype Associations	1.0	0.069523
RAB6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93003
PQBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39178
GSE88819_7_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Sperm plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.796
MON	DepMap CRISPR Gene Dependency	1.0	2.23446
chr4_46892368_G_A_b38	GTEx eQTL 2025	1.0	9.26503
ASNS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11926
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I2-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MORF4L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34164
SSTR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53084
SMARCAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24902
EYA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91784
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.42427
SP in perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.843571
GSE224599_0_v_1_tfcp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Salivary gland cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.5
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.4628
AU565	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.893624
Nasopharyngeal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.119
ZNF778	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83228
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GY-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
THNSL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3391
GSE203308_9_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Sarcoma_SARC_TCGA-DX-A8BH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HSPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48875
OTUD6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96463
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
mRNA_SOX9_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15922
CBR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55192
FKBP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57176
RNF169	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44182
HEL	DepMap CRISPR Gene Dependency	1.0	3.06063
tail of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.82695
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A3KG-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15922
GSE202434,GSE202438_8_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF705D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79553
SOWAHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8585
SENP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06297
MDP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76759
laterodorsal part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12314
Parkinson disease	KEGG Pathways 2026	1.0	null
GNB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71648
DDX59	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35442
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.39834
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4351
CUL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4263
Respirasome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
MZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.1873
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.063
neutropenia	GWASdb SNP-Disease Associations	1.0	0.742812
abnormality of the endocrine system	GWASdb SNP-Phenotype Associations	1.0	0.094019
ZNF558	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	122.829
SMC1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88292
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1163
Dlx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.8167
WASL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22997
supraoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.914457
LATS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05902
precommissural nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.889693
USP16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21003
TIMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54604
decitabine_homo sapiens_gpl570_gse30985	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.846834
EAPP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61087
MMRN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40881
KLHDC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33418
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4155
CSDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61523
NCIH2066	CCLE Cell Line Gene Expression Profiles	1.0	1.56626
NTMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97162
CA46	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73041
K562	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.04693
Lung adenocarcinoma_LUAD_TCGA-55-8092-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SH10TC	CCLE Cell Line Gene Expression Profiles	1.0	1.36673
Acute Myeloid Leukemia_LAML_TCGA-AB-2884-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mitochondrial part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
ZNF410	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.14693
FBXO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20345
TMEM121B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98126
MYOG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97042
NCIH358	CCLE Cell Line Gene Expression Profiles	1.0	2.65493
DMS53	CCLE Cell Line Gene Expression Profiles	1.0	1.62191
Lung adenocarcinoma_LUAD_TCGA-05-4396-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100434_HIP_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	9.86388
DNAJC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51474
hippocampus (hippocampal formation)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.861802
CCDC85B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0969
metabolic	GAD High Level Gene-Disease Associations	1.0	0.293278
TM31	CCLE Cell Line Gene Expression Profiles	-1.0	-2.0186
CAOV3	CCLE Cell Line Gene Expression Profiles	-1.0	-2.18001
Pharynx cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.064
U178	CCLE Cell Line Gene CNV Profiles	-1.0	-1.435
esr1_21713035_mcf7_lof_human_gpl570_gds4061	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.249373
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1043
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HF-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.047051
MAP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05567
Gonocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.209
AFF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34457
Huntington disease	KEGG Pathways 2026	1.0	null
EW8	DepMap CRISPR Gene Dependency	1.0	8.42593
SLC2A4RG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84013
YOD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87353
H3K36me3_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYADM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19073
organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Perturb_6300_KD_CGA_SRP355115	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
496100358_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.34763
mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
abnormality of the immune system	GWASdb SNP-Phenotype Associations	1.0	0.104414
BRD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59535
Lung squamous cell carcinoma_LUSC_TCGA-37-4130-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	285.56
SMIM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05241
rare	GeneRIF Biological Term Annotations	1.0	null
ZNF131	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.10552
GSE119978,GSE180930_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
abnormal sperm head morphology	MGI Mouse Phenotype Associations 2023	1.0	null
SAP30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87156
NFKB1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
POU5F1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8244
ADGRG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79734
HCC1954	CCLE Cell Line Gene CNV Profiles	1.0	1.94614
variation	GeneRIF Biological Term Annotations	1.0	null
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.619547
FOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	191.935
Perturb_6628_KO_TEAD1_SRP315348	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.79751
posteroventral (inferior) parietal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.963
GSE155972_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF391	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29373
PFDN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86065
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.4443
GSE206516,GSE206518_2_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
WIPF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54211
GSE169205_0_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
developmental disorder of mental health	GWASdb SNP-Disease Associations	1.0	0.363861
SEC23IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47641
H3K9me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
proton-transporting ATP synthase complex, coupling factor F(o)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.282
ventrolateral prefrontal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.24966
ASAH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74936
RPMI-7951	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.85815
communication disorder	GWASdb SNP-Disease Associations	1.0	0.873424
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3MV-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF-26484167-CHIP-SEQ-BCELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
70Z/3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.769
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184087_0_v_1_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
learning disability	GWASdb SNP-Disease Associations	1.0	0.398812
GSE193258,GSE193259_5_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PI4K2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78769
G124	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.971888
GSE195663_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ATP13A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72391
VEGFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4993
Brain Lower Grade Glioma_LGG_TCGA-S9-A6UB-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of cellular immune system	GWASdb SNP-Phenotype Associations	1.0	0.179556
PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
VMA21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84069
NHEJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5328
SRF	ENCODE Transcription Factor Targets	1.0	null
VAC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53464
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.24
MAJIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71959
OVMANA	CCLE Cell Line Gene CNV Profiles	-1.0	-2.35403
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.21702
GSE175787_13_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SIX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73998
OCT4-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
rostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11403
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8669
Renal clear cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.554
BACH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.1892
DAOY	CCLE Cell Line Gene Expression Profiles	1.0	1.38288
TMK1	DepMap CRISPR Gene Dependency	1.0	2.14302
PLEKHA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12145
ADH5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.20343
SP140L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93414
teratozoospermia	MGI Mouse Phenotype Associations 2023	1.0	null
FRAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48679
organelle part	GO Cellular Component Annotations 2015	1.0	null
GSE202434,GSE202438_13_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ion transport	GO Biological Process Annotations 2015	1.0	null
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.41401
Perturb_4504_KO_Hoxa1_SRP174196	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	13.4642
MT-ND4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28111
nervous system disease	GWASdb SNP-Disease Associations	1.0	0.143545
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6215
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.2423
GAREM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7601
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JU-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USP27X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62236
Nr2e1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.851
HCC1359	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36312
ARID3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.33191
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6ES-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2279	CCLE Cell Line Gene CNV Profiles	1.0	1.52773
Respiratory chain complex IV	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Lung squamous cell carcinoma_LUSC_TCGA-63-A5M9-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CNOT6L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51237
NIHOVCAR3	CCLE Cell Line Gene Expression Profiles	1.0	1.97818
BCP1	CCLE Cell Line Gene Expression Profiles	1.0	2.38679
Lung adenocarcinoma_LUAD_TCGA-55-8094-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
SMAD3	ChEA Transcription Factor Targets	1.0	null
FOXA1	ENCODE Transcription Factor Targets	1.0	null
PNRC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2445
SCAI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87332
MAEA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3962
codon	GeneRIF Biological Term Annotations	1.0	null
abnormality of higher mental function	GWASdb SNP-Phenotype Associations	1.0	0.368752
KYSE-150	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.873558
RAB41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15397
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.4833
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.857717
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_ALL-SYMBOL_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH1838	CCLE Cell Line Gene CNV Profiles	1.0	1.37688
male infertility	MGI Mouse Phenotype Associations 2023	1.0	null
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.7037
REST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84617
NCI-H1568	COSMIC Cell Line Gene Mutation Profiles	1.0	null
UBB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58903
THUMPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46398
risk	GeneRIF Biological Term Annotations	1.0	null
SERPINB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89918
GSE239688_4_v_0_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.578
Lung adenocarcinoma_LUAD_TCGA-55-1594-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
JUN::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2877
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8573
TDOTT	DepMap CRISPR Gene Dependency	1.0	3.86479
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.731927
KLHDC7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73043
CA SKI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.986218
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.14533
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03066
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.853533
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7X2-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
ARNT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7309
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DM-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44225
LIN54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38715
TMEM190	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31277
BEX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00846
VZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.88648
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.13817
TLE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38978
ZNF236	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29257
GSE142210_11_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
NDN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54462
speech disorder	GWASdb SNP-Disease Associations	1.0	0.873424
CLTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63012
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.929872
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
MEIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2512
POU2F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88771
periventricular nucleus, preoptic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0834
stratum pyramidale of rostral CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.87834
GSE88819_0_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039254
Hypertrichosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
127399	DepMap CRISPR Gene Dependency	1.0	2.10636
GSE88819_1_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02423
RIDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5089
496100555_TCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.30334
CA12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9781
OCUBM	DepMap CRISPR Gene Dependency	1.0	3.92367
Tirabrutinib (hydrochloride)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0147291
SOCS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8597
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8525
SH3BGRL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39501
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WH-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNF225	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48202
FOSL1::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.0123
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.929872
KASUMI1	CCLE Cell Line Gene CNV Profiles	1.0	1.75998
CHGA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1894
oxidative phosphorylation	KEGG Pathways	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SB-01A-21R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JDP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.8528
Sarcoma_SARC_TCGA-QQ-A5VB-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAL12T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.4844
GSE190177_1_v_0_sgpl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4430-01A-02R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal sperm mitochondrial sheath morphology	MGI Mouse Phenotype Associations 2023	1.0	null
Mitochondrial respiratory chain complex IV	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.676
ZNF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54858
oxidoreductase activity	GO Molecular Function Annotations 2015	1.0	null
PRXL2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5807
DACT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94563
mRNA_GADD45A_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
FAM43A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37521
IL18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21692
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.871546
PANC 02.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03129
SJSA1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57369
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.3471
single-organism localization	GO Biological Process Annotations 2015	1.0	null
SERINC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.01383
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.21652
SW900	CCLE Cell Line Gene CNV Profiles	1.0	1.5493
SKES1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.04877
GSE95077_1_v_0_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
retroparafascicular area of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.54434
carboplatin_homo sapiens_gpl570_gse13525	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EVSAT	DepMap CRISPR Gene Dependency	1.0	2.68557
GSE125014_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
substance abuse	GWASdb SNP-Disease Associations	1.0	0.327643
CYREN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89022
U266B1	CCLE Cell Line Gene Expression Profiles	1.0	1.59418
SUDHL5	DepMap CRISPR Gene Dependency	1.0	3.47511
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
carbohydrate metabolism disease	GWASdb SNP-Disease Associations	1.0	0.310615
ZBED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40533
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.23756
H3K27me3_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8809
GSE149264,GSE149267_4_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FBXO44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30117
MTFMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06997
YWHAE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79824
methylphenidate_mus musculus_gpl11180_gse33619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZFP36L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.28271
primary visual cortex (striate cortex, area V1/17)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.32558
ZFP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91196
PMC6781638__F4	PFOCR Pathway Figure Associations 2023	1.0	null
GSE198165,GSE198166_8_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
leukocyte disease	GWASdb SNP-Disease Associations	1.0	0.330555
NCIH358	CCLE Cell Line Gene CNV Profiles	1.0	1.60189
UBF1/2-26484160-CHIP-SEQ-FIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Mitotic arrest phase fetal germ cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21041
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.861802
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45U-01A-12R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ITSN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53646
mediodorsal nucleus of thalamus_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.51899
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.857383
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01226
PAFAH1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91114
GSE240027,GSE240030_5_v_0_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PEMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72622
MZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.845286
Primary localized cutaneous amyloidosis 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.432
NLRX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41186
ORMDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43218
SKBR3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.65318
GSE240027,GSE240030_5_v_4_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.231795
Specific granule lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.902
GSE236502_1_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
RTEL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54546
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Thermogenesis	KEGG Pathways 2026	1.0	null
IZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.922479
BRWD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67141
SLC25A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67744
TSHZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42932
organelle inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
WDHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74242
TMEM126A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91048
Brain Lower Grade Glioma_LGG_TCGA-HT-A619-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EPOR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96372
mRNA_MEF2C_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
HOXA5	JASPAR Predicted Transcription Factor Targets	1.0	null
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040018
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10167
GSE188832,GSE188835_0_v_1_irf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SRY	JASPAR Predicted Transcription Factor Targets	1.0	null
HUG1N	CCLE Cell Line Gene CNV Profiles	-1.0	-2.20145
CNBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10236
PMC4259449__F5	PFOCR Pathway Figure Associations 2024	1.0	null
TCF7L2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1459
Type 2 diabetes	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.6
Mitochondrial DNA depletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.053
DDX20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6159
Prostate adenocarcinoma_PRAD_TCGA-J4-A83J-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
3-methylcrotonyl-CoA carboxylase complex, mitochondrial	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.055
nasopharyngeal	GeneRIF Biological Term Annotations	1.0	null
496100499_PCx_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	5.4428
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
NCIH1781	CCLE Cell Line Gene CNV Profiles	-1.0	-1.94334
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PZ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HLA-A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.22705
ELOVL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54013
CHD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41985
mediodorsal nucleus of thalamus_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09527
RAB3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81549
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6691
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8126
diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.316493
GSE193258,GSE193259_5_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
sensory system disease	GWASdb SNP-Disease Associations	1.0	0.076316
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6701
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.11018
GSE102870_11_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34152
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.4356
NUDT12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69992
Hmx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.0334
Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JHU011	DepMap CRISPR Gene Dependency	1.0	3.56411
NDUFAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63265
MTA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48679
COPS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15546
CSGALNACT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25121
COL18A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27437
INAFM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15089
BB30HNC	DepMap CRISPR Gene Dependency	1.0	2.1005
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30726
TJP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95041
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Lung adenocarcinoma_LUAD_TCGA-62-A46O-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HARA	CCLE Cell Line Gene CNV Profiles	1.0	1.76839
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5894-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPNS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40605
substrate-specific transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
PROKR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72705
ECGI10	CCLE Cell Line Gene CNV Profiles	-1.0	-2.58597
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.408
PSMA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55069
BFTC-909	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03066
Spi1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.6656
SEPTIN9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44267
ZNF714	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10606
dorsolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.940989
JHH-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
amygdaloid complex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.843956
ZNF555	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56455
GSE225762_1_v_0_pcmt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PI4KB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24686
HCC827	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.70093
GOLGA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69522
RMGI	Achilles Cell Line Gene Essentiality Profiles	1.0	1.33352
ventrolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.57454
SOX12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7717
CDC42EP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28326
Hoxa13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.6989
centromedian nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26694
DMRTC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.10364
ZNF417	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94846
DEPDC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92539
P3HR1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.03902
GSE196962_4_v_3_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
hydrogen ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
M059K	CCLE Cell Line Gene Expression Profiles	1.0	1.56227
BRD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55349
USF2	ENCODE Transcription Factor Targets	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HT-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	48.6702
SPRING1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79308
GSE169697,GSE169725_1_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RASSF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75948
YAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5319
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.954507
GSE175883_0_v_1_dis3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PPP1R15A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33463
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A217-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRCAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54436
amygdaloid complex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.917391
GSE191015_0_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1665
GSE88819_1_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hypomelanosis of Ito	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
Ikzf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.1361
INO80C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.44033
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.56429
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19P-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
orbital frontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12307
attention deficit hyperactivity disorder	GWASdb SNP-Disease Associations	1.0	0.653298
DLX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1707
OVOL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08697
headache	GWASdb SNP-Phenotype Associations	1.0	0.325689
neurological speech impairment	GWASdb SNP-Phenotype Associations	1.0	0.394985
CCDC74B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69408
Lung adenocarcinoma_LUAD_TCGA-NJ-A55R-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
arcuate nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.51523
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1627
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.62984
WDR77	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8158
abnormality of blood and blood-forming tissues	GWASdb SNP-Phenotype Associations	1.0	0.09034
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
cation transport	GO Biological Process Annotations 2015	1.0	null
Lhx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.65
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GY-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.75392
C14orf93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86564
Cytochrome C oxidase, subunit VIIB	InterPro Predicted Protein Domain Annotations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41N-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAGLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74889
DUSP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57228
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.5571
AXIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.39929
SG in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.963156
VENTX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0743
dorsolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1384
layer III of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.869074
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.985321
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.19164
intracellular part	GO Cellular Component Annotations 2015	1.0	null
MXD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45704
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24402
Perrault syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
RMND5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71812
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1043
SLITRK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73152
ASRGL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01882
Nobox	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.3947
PMC3470785-NIHMS377161-supplement-3.pdf-620-TIGD6_TIGD6	Rummagene Transcription Factor Associations 2026	1.0	null
JA-98-CL60_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.647112
KMT5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78098
GSE206516,GSE206518_5_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CREB3L4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7926
anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.861802
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A49A-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE199255,GSE199356_6_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01480	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.35685
Nonalcoholic fatty liver disease	WikiPathways Pathways 2024	1.0	null
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	118.459
CAVIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15127
D542MG	DepMap CRISPR Gene Dependency	1.0	2.03807
NCI-H1299	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.71042
cellular_component	GO Cellular Component Annotations 2015	1.0	null
PLPP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46097
NAB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12169
mitochondrial respiratory chain	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Skeletal Muscle Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.08643
outer SZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.958508
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Hoxd13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.3473
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24402
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08479
GSE132948,GSE132949_0_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ADRM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08746
CIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75025
myopia	GWASdb SNP-Phenotype Associations	1.0	0.435588
attention deficit hyperactivity disorder	GWASdb SNP-Phenotype Associations	1.0	0.557335
TNFSF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69167
RARA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.3996
RAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.598
20208059-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
ZEB2_01_56	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	4.11906
PTPRG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45267
BBS12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84468
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18204
CYB561D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99363
EN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43891
SARS-CoV_48Hour_20090954_GSE17400	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.34158
primary motor cortex (area M1, area 4)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.931512
GSE189599,GSE196004_0_v_1_bend2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.0042
transmembrane transport	GO Biological Process Annotations 2015	1.0	null
HOXC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28692
TAOK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65264
PMC3419980-leu201249x2.xls-RUNX1-ETO_siRE_ChIPSeq_peaks_ge-gene_name_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
Cytochrome C oxidase, subunit VIIB, domain	InterPro Predicted Protein Domain Annotations	1.0	null
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.85117
SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.6828
MAP3K11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94336
NEUROD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32131
GID8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7728
reading disorder	GWASdb SNP-Disease Associations	1.0	0.873424
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Oxygen	HMDB Metabolites of Enzymes	1.0	null
ventrolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26261
GSE217363_5_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169356_0_v_5_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PLAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91263
Lung adenocarcinoma_LUAD_TCGA-50-6673-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF662	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74621
Cardiac muscle contraction	KEGG Pathways 2026	1.0	null
KMS27	CCLE Cell Line Gene Expression Profiles	1.0	1.63831
ACP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85563
ZNF709	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50795
RT11284	CCLE Cell Line Gene CNV Profiles	1.0	1.59621
FTC133	CCLE Cell Line Gene Expression Profiles	1.0	1.39682
MHHES1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.27828
CAMSAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49378
MLXIPL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8885
Nfatc1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.5595
MEF2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	75.3481
PMC11257629-media-3.xls-Dong_et_al_2023-Comparision_of_METTL3_KD_DEG_with_Dong_et_al_GRGs_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF814	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30862
TM6SF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09518
NEURL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87683
FAM47E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44114
PLBD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27447
Foxo3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.4161
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VEZT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39474
FH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09584
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
TTC30B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89743
496100545_HIP_possible Alzheimer's disease_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.31178
ARPP19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30207
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27867
cognitive disorder	GWASdb SNP-Disease Associations	1.0	0.873424
Brain Lower Grade Glioma_LGG_TCGA-HT-7606-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IGR39	Achilles Cell Line Gene Essentiality Profiles	1.0	1.11755
IL4R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79493
SLC7A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15065
19192944-TableS4	GeneSigDB Published Gene Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.880956
PKNOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6806
H2803	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TCF25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3753
GSE236502_2_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JE-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HW-7487-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CKLF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32368
KMS12BM	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.44564
HCC1419	DepMap CRISPR Gene Dependency	1.0	2.43912
GSE154081_3_v_0_sildenafil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CASP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86666
proton transport	GO Biological Process Annotations 2015	1.0	null
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7657
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7429-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Post bronchodilator FEV1	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.539794
ERCC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60649
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20351
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70G-01B-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE206516,GSE206518_3_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.4704
NEK8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93589
A375	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BT20	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.25894
RERFLCAD1	CCLE Cell Line Gene CNV Profiles	1.0	2.09033
HS229T	CCLE Cell Line Gene Expression Profiles	-1.0	-2.34424
RUNX2	ChEA Transcription Factor Targets	1.0	null
PHF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96225
AMIGO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45537
Perturb_15010_KO_Eed_SRP365240	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
SIK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02479
496100573_HIP_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.24137
AXL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49863
NCIH1781	CCLE Cell Line Gene Expression Profiles	-1.0	-1.97762
TINF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.09194
ZNF69	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62098
myopia	GWASdb SNP-Disease Associations	1.0	0.509966
ATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7778
NCI-H322M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
496100361_TCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.50177
ZCCHC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85697
Congenital myasthenic syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
GSE225735_1_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE196962_2_v_1_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pathways of neurodegeneration - multiple diseases	KEGG Pathways 2026	1.0	null
CHMP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77188
LMCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.19843
ZMYM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33856
Brain Lower Grade Glioma_LGG_TCGA-QH-A65Z-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE200673,GSE200691_2_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03066
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1733
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18204
posteroventral (inferior) parietal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.54928
TBC1D23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12959
Lung adenocarcinoma_LUAD_TCGA-MN-A4N4-01A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hair root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.583
SETD1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35411
NCIH1355	DepMap CRISPR Gene Dependency	1.0	2.6028
USF2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PGAM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82824
WDR5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63597
Rectum adenocarcinoma_READ_TCGA-F5-6810-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF382	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.6853
Brain Lower Grade Glioma_LGG_TCGA-DH-A66B-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.9977
LIMA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24428
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21041
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F2-06A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZSCAN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31775
Brain Lower Grade Glioma_LGG_TCGA-S9-A6TS-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8183
Brain Lower Grade Glioma_LGG_TCGA-QH-A65R-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BICR22	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53333
GSE130396_7_v_6_braf_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2J2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14048
KURAMOCHI	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.05352
RPS26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66306
AR	ChEA Transcription Factor Targets	1.0	null
496100648_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.70238
GSE204811,GSE204813_1_v_3_trim29_human	RummaGEO Gene Perturbation Signatures	1.0	null
DNAJC19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02242
WSU-NHL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.67603
18614019-TableS4c	GeneSigDB Published Gene Signatures	1.0	null
Mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.35
ESRRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0769
glucose metabolism disease	GWASdb SNP-Disease Associations	1.0	0.310615
GSE206516,GSE206518_6_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03066
ZNF160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13897
HCC1806	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.12006
TRAF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32787
INF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.09865
Lung squamous cell carcinoma_LUSC_TCGA-37-5819-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A3VY-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20R-01A-12R-A16R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
NFIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63357
ABHD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39326
ZFHX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53867
Brain Lower Grade Glioma_LGG_TCGA-HT-A74K-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPIN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91915
GSE241701_1_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24402
cation transmembrane transport	GO Biological Process Annotations 2015	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3MO-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TNRC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84361
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
GARRE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81802
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of refraction	GWASdb SNP-Phenotype Associations	1.0	0.3479
RT112	CCLE Cell Line Gene CNV Profiles	1.0	1.37989
GSE125014_6_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPS6KA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96038
BC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HNF4A	ChEA Transcription Factor Targets	1.0	null
RBM15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19595
posteroventral (inferior) parietal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21484
GSE196962_2_v_6_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
DMS-53	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HCC1162	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03066
SW954	DepMap CRISPR Gene Dependency	1.0	2.2844
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07084
Alzheimer disease	KEGG Pathways 2026	1.0	null
mRNA_SOX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GOLGA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94169
EPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96055
Migraine - clinic-based	GWAS Catalog SNP-Phenotype Associations	1.0	0.048624
Foxj3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.0006
PMC4021073-1471-2407-14-278-S4.xlsx-Sheet1-Supplementary_Table_S5_Genes_with_GATA3_ChIP-seq_peak_within_10kb_from_transcription_start_site_TSS_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE134375_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
type 2 diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.890776
TK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44225
LRAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39744
SMAD3-21741376-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
NCIH1836	CCLE Cell Line Gene CNV Profiles	1.0	2.00423
PIP5K1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26818
KDM6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73208
STAT1::STAT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.9919
SNU-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26835
CERCAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31329
CGB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2514
mRNA_TCF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
HCT-116	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NFI-21473784-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SEPTIN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22873
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.1223
SCX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21811
SH2B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82362
pharynx cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.139723
neutropenia	GWASdb SNP-Phenotype Associations	1.0	0.641745
immune system disease	GWASdb SNP-Disease Associations	1.0	0.055101
abnormality of central motor function	GWASdb SNP-Phenotype Associations	1.0	0.942765
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8332
PROX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.901
DMS53	CCLE Cell Line Gene CNV Profiles	1.0	1.58976
MCOLN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07621
EJM	CCLE Cell Line Gene CNV Profiles	1.0	1.32834
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_5036_KD_Smarcc1_SRP221174	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.5373
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GFPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70589
abnormal glucose homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.232672
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
respiratory chain complex IV	GO Cellular Component Annotations 2023	1.0	null
GSE158285_0_v_1_ddx5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
medial portion of the shell	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.930615
cytochrome-c oxidase activity	GO Molecular Function Annotations 2015	1.0	null
neurodevelopmental abnormality	GWASdb SNP-Phenotype Associations	1.0	0.766703
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
MORN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11981
hydrogen ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
STRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89266
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.048081
abnormality of extrapyramidal motor function	GWASdb SNP-Phenotype Associations	1.0	0.942765
ARL4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56362
AMIGO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08253
TBCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15795
H1-5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68552
MLLT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91003