association dataset threshold value standardized value NDFIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07413 GTEX-PSDG-0926-SM-2I5FP GTEx Tissue Sample Gene Expression Profiles 1.0 0.834037 GSE197555_0_v_2_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-NPJ8-0011-R11A-SM-2YUMS GTEx Tissue Sample Gene Expression Profiles 1.0 1.16272 MAX JASPAR Predicted Transcription Factor Targets 1.0 null PPHLN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81853 THRAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00074 mainolfactoryepithelium.MOE. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.13136 nucleus accumbens, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.955549 Organelle inner membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 SLC35E1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.12272 PDLIM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11498 HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39887 MZ in retrosplenial cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.86353 RAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.5895 IZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07073 ventral posterior inferior nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.32628 H3K9me3_U2OS_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PRELID3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11171 Nuclear aryl hydrocarbon receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.677 H3K27me3_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KO-8403-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-6401-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8437-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null U937 CCLE Cell Line Gene Expression Profiles 1.0 2.99777 GA-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34491 stratum pyramidale of rostral CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.22181 NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.828632 ERF::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.2558 MAGEH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.94386 SCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.908915 VZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.75498 hsa-miR-1468 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 AMIGO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07751 primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.79467 membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null BT-483 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.47559 DPM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86726 inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.80477 TRRAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24293 CTCF_GM12875_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RSPO4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61179 trochlear nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.31207 POLR2AphosphoS5_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4XX-0011-R5A-SM-46MWN GTEx Tissue Sample Gene Expression Profiles 1.0 1.11373 GSE146982_7_v_5_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null epithelioma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051324 THRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 141.68 IPO9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22091 lateral hypothalamic area, tuberal region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.06615 GSE169152_3_v_2_ibrutinib_human RummaGEO Drug Perturbation Signatures -1.0 null TPD52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01025 Non-alcoholic fatty liver disease KEGG Pathways 2026 1.0 null H3K9me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CNDP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02148 RABEPK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06907 CWF19L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.06342 FOXO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18441 epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05128 MEGF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32158 Cellular response to chemical stress Reactome Pathways 2024 1.0 null GTEX-U8T8-1126-SM-4DXUE GTEx Tissue Sample Gene Expression Profiles 1.0 2.2024 RINT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90885 fastigial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01562 NCIN87 CCLE Cell Line Gene CNV Profiles -1.0 -1.54995 GTEX-Q734-2026-SM-3GADA GTEx Tissue Sample Gene Expression Profiles 1.0 1.12453 Esophagus - Gastroesophageal Junction GTEx Tissue Gene Expression Profiles 2023 1.0 7.21213 H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null JIYOYE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34491 PELI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72011 STAT1-17558387-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CNN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90845 ZNF462 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65597 RUNX2 ChEA Transcription Factor Targets 1.0 null cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040002 HOXC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5436 SW48 CCLE Cell Line Gene Expression Profiles 1.0 1.45713 Acute Myeloid Leukemia_LAML_TCGA-AB-2858-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7969 HMGB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80898 GPX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83119 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF331 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.2741 DU-145 COSMIC Cell Line Gene Mutation Profiles 1.0 null RAB6D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27261 K-562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.919051 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.049811 CHFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35015 H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GY-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3376-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mitochondrial membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.043214 SNAI2_01_292 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.42895 GTEX-UPJH-0126-SM-4IHLL GTEx Tissue Sample Gene Expression Profiles 1.0 1.92992 integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050332 CLPP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58101 ZNF391 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29373 PRECLH CCLE Cell Line Gene Expression Profiles -1.0 -1.87317 NCI-H1975 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17864 SUZ12-18974828-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRO-1726-SM-3LK6C GTEx Tissue Sample Gene Expression Profiles 1.0 0.997148 Brain Lower Grade Glioma_LGG_TCGA-S9-A7R2-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AGS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13213 H3K9me3_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MRPL15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72006 GTEX-XQ8I-0126-SM-4BOPL GTEx Tissue Sample Gene Expression Profiles 1.0 0.824415 MSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.6802 ACVR1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.24159 HCC1395 CCLE Cell Line Gene Expression Profiles 1.0 1.51263 lateral habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.34404 GTEX-OXRO-1226-SM-48TDL GTEx Tissue Sample Gene Expression Profiles 1.0 1.19917 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RF-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JA-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PL18 COSMIC Cell Line Gene Mutation Profiles 1.0 null IGF2BP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.94152 253J DepMap CRISPR Gene Dependency 1.0 4.54667 HCC1806 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.705588 inorganic cation transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null DLST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75714 GTEX-QLQW-1426-SM-2S1QU GTEx Tissue Sample Gene Expression Profiles 1.0 0.826183 RAB23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30757 STAT5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31086 GTEX-U3ZM-1626-SM-4DXSK GTEx Tissue Sample Gene Expression Profiles 1.0 1.65393 EN1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.6165 MT2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34936 KNOP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6446 HCC1395 CCLE Cell Line Gene CNV Profiles 1.0 1.92539 Brain Lower Grade Glioma_LGG_TCGA-TM-A7C3-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SW 48 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05106 organelle membrane GO Cellular Component Annotations 2015 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A7QX-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PEX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.33031 GSE126621,GSE126920_1_v_3_dppa4_mouse RummaGEO Gene Perturbation Signatures -1.0 null Primary B cells from cord blood Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -2.08751 GSE147366_1_v_0_med13_human RummaGEO Gene Perturbation Signatures -1.0 null GSE131377_1_v_0_spocd1_mouse RummaGEO Gene Perturbation Signatures -1.0 null proton transport GO Biological Process Annotations 2015 1.0 null MORN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11981 JKAMP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30353 Pou5f1::Sox2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.7587 inferior olive, dorsal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.95842 intracellular organelle part GO Cellular Component Annotations 2015 1.0 null Papillary Carcinoma of the Thyroid_Thyroid Gland (MMHCC)_GSE3467 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.46965 A-498 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10211 C5orf22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88778 FIBIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2134 cytoplasmic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.043328 REST-19997604-NEURONS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE174498,GSE174500_0_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null CHST7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98877 GTEX-TSE9-0011-R9A-SM-3DB7Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.843654 GTEX-QVJO-0126-SM-3GIK4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.25417 GRAMD1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.73452 SLC45A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20552 NAPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75783 small intestine HPA Tissue Protein Expression Profiles 1.0 3.27095 GPC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80735 TOMM22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.13284 GTEX-Q734-1626-SM-48U1B GTEx Tissue Sample Gene Expression Profiles 1.0 1.09209 SNIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47158 single-organism transport GO Biological Process Annotations 2015 1.0 null CTCF_GM19238_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCFL_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mRNA_NIPBL_20720539 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTEX-T2IS-2026-SM-4DM6W GTEx Tissue Sample Gene Expression Profiles 1.0 1.35335 SNU1076 CCLE Cell Line Gene CNV Profiles 1.0 1.4079 SKMEL1 CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 Copper ion transmembrane transporter complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.591 establishment of localization GO Biological Process Annotations 2015 1.0 null RMG-I Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.943839 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4712-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TSPAN12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02196 Mitochondrial respirasome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.587 Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SL-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mitochondrial membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.135798 GTEX-OXRN-2626-SM-48TBX GTEx Tissue Sample Gene Expression Profiles 1.0 1.0532 SMAD2-18955504-HaCaT-human ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-WWYW-0426-SM-3NB31 GTEx Tissue Sample Gene Expression Profiles 1.0 0.938527 OTUD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.3895 Integument TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Kidney Chromophobe_KICH_TCGA-KL-8329-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cytoplasmic part GO Cellular Component Annotations 2015 1.0 null TAMALIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55921 PPARG-20887899-3T3-L1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null ARHGEF12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4853 MINK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61536 DNAJC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.25803 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4688-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-UTHO-3126-SM-3P5ZB GTEx Tissue Sample Gene Expression Profiles 1.0 1.20384 CAPNS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05712 membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Rectum adenocarcinoma_READ_TCGA-DT-5265-01A-21R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MZ in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.65816 GTEX-POMQ-1426-SM-3P61D GTEx Tissue Sample Gene Expression Profiles 1.0 0.973278 GTPBP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21053 PFDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29278 LMBRD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87378 KPNB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0103 monovalent inorganic cation transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null CFAP126 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90657 GTEX-O5YV-0426-SM-3LK66 GTEx Tissue Sample Gene Expression Profiles 1.0 0.8444 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 SPART CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84878 mitochondrial inner membrane GO Cellular Component Annotations 2015 1.0 null L-363 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.79105 EM2 CCLE Cell Line Gene CNV Profiles -1.0 -1.42367 GTEX-QLQW-1026-SM-447A9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.69967 FGFR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28582 CAMK2N2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96251 brain GTEx Tissue Gene Expression Profiles 1.0 0.960278 Brain Lower Grade Glioma_LGG_TCGA-HT-7684-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ANKRD13D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.33042 EHD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21695 Prostate adenocarcinoma_PRAD_TCGA-Y6-A8TL-01A-21R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-4A-A93X-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SREK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66371 OTUD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.10403 CCDC74B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72895 H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Respiratory system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 COA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86185 GTEX-U8XE-0126-SM-4E3I3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.6562 GTEX-R55E-0726-SM-48FCZ GTEx Tissue Sample Gene Expression Profiles 1.0 2.01718 MFSD14A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41678 MZ in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.862173 CCT5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42327 VAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7818 substrate-specific transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null outer CP in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.894088 FOXN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86141 GSE147366_3_v_5_med13_human RummaGEO Gene Perturbation Signatures -1.0 null Perturb_17326_KO_Dis3_SRP328540 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 ATP5F1E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60978 RIPK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48191 H3K36me3_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null proton-transporting two-sector ATPase complex, proton-transporting domain COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.215 COG7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53438 Ruminal fluid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.837 H3K9me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MHHNB11 DepMap CRISPR Gene Dependency 1.0 3.13923 PECAPJ34CLONEC12 CCLE Cell Line Gene CNV Profiles 1.0 1.41969 GTEX-QLQW-1326-SM-2S1QS GTEx Tissue Sample Gene Expression Profiles 1.0 1.4332 GTEX-U4B1-1426-SM-4DXTX GTEx Tissue Sample Gene Expression Profiles 1.0 0.946993 VMRCRCW CCLE Cell Line Gene CNV Profiles -1.0 -2.09036 RIPK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.07254 HELT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53669 Brain Lower Grade Glioma_LGG_TCGA-HT-7474-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TMEM267 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32634 central gray of the pons, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.59369 Brain Lower Grade Glioma_LGG_TCGA-DU-A5TW-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EJM CCLE Cell Line Gene CNV Profiles 1.0 2.59568 LOX-1_OE_GDS4262_434_human_HAECT - aortic endothelial cell line - 12 Hours GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null hsa-miR-17 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 CDH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32981 NUDUL1 CCLE Cell Line Gene CNV Profiles -1.0 -1.68077 Perturb_15979_KO_Tsga8_SRP254760 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.73664 Cardiac muscle contraction KEGG Pathways 2026 1.0 null USP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73945 CTCF_skin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BTF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5642 striatum_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.946306 Organellar small ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.667 496100389_HIP_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.05724 VMA21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84069 GTEX-S3XE-1526-SM-4AD5A GTEx Tissue Sample Gene Expression Profiles 1.0 1.88542 ZSCAN30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46486 TIMM8B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55384 CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13213 EXTL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34479 Prostate adenocarcinoma_PRAD_TCGA-EJ-5527-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1355 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.876103 ALS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10447 medial geniculate nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.984804 GTEX-OIZH-2126-SM-3NB1P GTEx Tissue Sample Gene Expression Profiles 1.0 1.79109 ALX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.7078 CTCF_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null UTF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67743 estradiol_mus musculus_gpl4134_gse23241 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZNF580 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.47541 pyramidal layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15276 mRNA_GATA3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTF3C5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36185 NCI-H2196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19388 RSC1A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86179 CTCF_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UTHO-0011-R11A-SM-3GIJE GTEx Tissue Sample Gene Expression Profiles 1.0 0.890694 PHOX2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.7649 PREB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51965 mammillary body, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.14002 NCIH1975 CCLE Cell Line Gene Expression Profiles 1.0 1.60538 EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.40092 MED12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1988 CTCF_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE191105_2_v_4_nat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null catalytic activity GO Molecular Function Annotations 2015 1.0 null NP8 DepMap CRISPR Gene Dependency 1.0 2.61881 Prostate adenocarcinoma_PRAD_TCGA-EJ-A65B-01A-12R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-6590-01A-12R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STON2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89636 TLNRD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28686 inferior rostral gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.44671 PSMA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60098 NCIH2009 CCLE Cell Line Gene Expression Profiles 1.0 2.71712 LRRC40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41701 cation transmembrane transport GO Biological Process Annotations 2015 1.0 null GTEX-UTHO-0011-R6A-SM-3GIJW GTEx Tissue Sample Gene Expression Profiles 1.0 0.964753 Brain Lower Grade Glioma_LGG_TCGA-DH-A7UU-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A71V-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAPK1_knockdown_131_GSE31534 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.35299 LIFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.15994 NCI-H1694 COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 central nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.56222 PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_37_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null SLC25A51 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95002 Mitochondrial inner membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11637 SLC29A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92973 DUSP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57228 primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.842848 FADU CCLE Cell Line Gene CNV Profiles 1.0 3.27868 POLR2A ENCODE Transcription Factor Targets 1.0 null PIP4P2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55512 JHH-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13831 TRIP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17921 GGTLC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63979 SEC61G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31311 BRIX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06304 Lung adenocarcinoma_LUAD_TCGA-86-8073-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KDM6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48368 HCC70 DepMap CRISPR Gene Dependency 1.0 2.18929 ZNF549 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.7792 ZNF433 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44264 LATS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05902 SLC25A13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03983 GTEX-S33H-0126-SM-4AD62 GTEx Tissue Sample Gene Expression Profiles 1.0 1.81978 chr14_93347866_T_A_b38 GTEx eQTL 2025 1.0 1.85338 MRPS23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.85444 ventrolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.2176 Prostate adenocarcinoma_PRAD_TCGA-KK-A7B2-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OCI-M1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0056 Intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 RTKN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15073 Prostate adenocarcinoma_PRAD_TCGA-KK-A8IB-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ACTR1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42848 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8043-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H2452 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10211 mitochondrion LOCATE Predicted Protein Localization Annotations 1.0 null FUBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87164 496100636_FWM_probable Alzheimer's disease_no TBI_86_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.52359 ZNF248 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61044 WDR48 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62608 SCN1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1155 Lung TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 TP63 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.2319 HCC2185 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.3297 Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L6-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CPEB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67631 TRPC4AP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2479 DTX3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84199 mediodorsal nucleus of thalamus_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.16733 PMC10352551-ACEL-22-e13861-s001.pdf-12-MYC_MYC Rummagene Transcription Factor Associations 2026 1.0 null HBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34311 lateral habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.831196 GSE229671,GSE229673_3_v_1_yrdc_human RummaGEO Gene Perturbation Signatures -1.0 null ZNF551 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73601 posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.908087 GTEX-TSE9-1226-SM-4DXTM GTEx Tissue Sample Gene Expression Profiles 1.0 0.878264 CTCF_HCT116_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null deep layers of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.952846 CTAGE4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61345 Organellar large ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.573 TEAD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8759 SDHAF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76864 hsa-miR-93 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 OXER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71094 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3434-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U412-2026-SM-4DXSI GTEx Tissue Sample Gene Expression Profiles 1.0 0.838793 TMX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70805 caudal (posterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02887 SCLC21H CCLE Cell Line Gene Expression Profiles 1.0 1.36977 GTEX-RU72-0326-SM-2TF5T GTEx Tissue Sample Gene Expression Profiles 1.0 1.06572 Uterine Carcinosarcoma_UCS_TCGA-N8-A4PQ-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.896221 membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Brain Lower Grade Glioma_LGG_TCGA-CS-6667-01A-12R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CLDN7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93902 mRNA_ZSCAN4C_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null Barrett's esophagus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.574 anterior (rostral) cingulate (medial prefrontal) cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02108 JL1 CCLE Cell Line Gene CNV Profiles -1.0 -1.45823 mitochondrial envelope COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GPANK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34049 NCI-H1304 COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 CP in caudal hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.855455 H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null PANC 05.04 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.962885 STOML1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92138 496100484_FWM_no dementia_no TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.88958 E4F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16967 RUNX2-22187159-PCA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null NFAT5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82024 GTEX-UTHO-0011-R4A-SM-3GIJP GTEx Tissue Sample Gene Expression Profiles 1.0 1.19955 IP6K2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76955 Prostate adenocarcinoma_PRAD_TCGA-HC-7740-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ANKRD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45092 GTEX-W5X1-0826-SM-3GILN GTEx Tissue Sample Gene Expression Profiles 1.0 0.865392 KMS26 DepMap CRISPR Gene Dependency 1.0 4.19299 MTA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48679 Prostate adenocarcinoma_PRAD_TCGA-KK-A6E2-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null caudal presubiculum (postsubiculum) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.959144 mitochondrial respiratory chain COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.526341 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FM-8000-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 18614019-TableS4d GeneSigDB Published Gene Signatures 1.0 null SCP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95526 MCF10F Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.64144 Respiratory chain complex IV COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 GSE241701_4_v_0_daxx_mouse RummaGEO Gene Perturbation Signatures -1.0 null Hand1::Tcf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.8966 Olig2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.8727 DPH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98231 IGF1R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53277 NRF1 JASPAR Predicted Transcription Factor Targets 1.0 null CTCF_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Outer dense fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.143 posterior (caudal) superior temporal cortex (area 22c)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.883999 IKZF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09307 Rumen epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.565 HCC366 DepMap CRISPR Gene Dependency 1.0 2.56524 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.049811 ZNF653 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31701 G-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.919051 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null JIMT-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.2432 GTEX-WWYW-0011-R11A-SM-3NB38 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01544 retroparafascicular area of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.836061 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null paraventricular nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.996892 amygdaloid complex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.39751 adenocarcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.250953 KMBC2 CCLE Cell Line Gene Expression Profiles -1.0 -1.9198 NCIH1436 CCLE Cell Line Gene Expression Profiles 1.0 1.41736 striatum_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01466 precentral gyrus, right, bank of the precentral sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.14013 CTCF_GM12867_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nkx3-2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.1671 YIPF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2497 GTEX-NPJ8-0011-R9a-SM-2YUN5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.34386 CA2 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 3.11703 PMC8787225-Data_Sheet_1.xlsx-STable_2_DEG-Supplementary_Table_2_1150_up-_and_down-regulated_differential_expressed_genes_upon_GATA2_activation_GATA2 Rummagene Transcription Factor Associations 2026 1.0 null TNFRSF10B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8212 TRIM52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00067 Lung adenocarcinoma_LUAD_TCGA-MN-A4N4-01A-12R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary auditory cortex (core)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.36602 HDGFL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45667 GTEX-Q734-0526-SM-2I3EH GTEx Tissue Sample Gene Expression Profiles 1.0 1.06993 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68G-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral hypothalamic area, anterior region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.69683 Edinger-Westphal nucleus (accessory oculomotor nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.19718 GTEX-XBED-2026-SM-4AT5D GTEx Tissue Sample Gene Expression Profiles 1.0 1.9086 intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 SYVN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39254 FLI1::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.5431 UMRC2 CCLE Cell Line Gene CNV Profiles -1.0 -2.15629 SEPTIN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69655 corpus callosum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.60894 ID4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70678 GTEX-XQ3S-2526-SM-4BOOG GTEx Tissue Sample Gene Expression Profiles 1.0 0.97949 SEPHS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54732 CTCFL ENCODE Transcription Factor Targets 1.0 null MYC_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TSPAN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.06693 cellular_component LOCATE Curated Protein Localization Annotations 1.0 null GTEX-XQ8I-0226-SM-4BOPM GTEx Tissue Sample Gene Expression Profiles 1.0 1.12668 NBPF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9475 ZNF184 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.4177 SG in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.18185 VIIIB, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.908975 KINGS1 DepMap CRISPR Gene Dependency 1.0 2.08936 Perturb_8589_KO_Gsap_SRP282467 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.97979 posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.29579 TRAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50119 Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nonalcoholic fatty liver disease WikiPathways Pathways 2024 1.0 null frontal pole, right, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.42441 POU2F2 JASPAR Predicted Transcription Factor Targets 1.0 null WDR35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36838 CAL62 CCLE Cell Line Gene CNV Profiles -1.0 -2.0745 HMX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30624 TBX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94722 OPA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37821 TACSTD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75208 BHLHE40 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.7965 C21orf58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30445 Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DX-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87961 CXCL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90531 GSE144115_4_v_3_stag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null USP16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21003 GTEX-O5YV-1826-SM-2YUNI GTEx Tissue Sample Gene Expression Profiles 1.0 0.892783 hippocampus (hippocampal formation)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.13824 C17orf97 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33212 NCIH2106 CCLE Cell Line Gene Expression Profiles 1.0 1.67317 496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.24489 MSH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25366 GTEX-NL3H-0011-R1a-SM-48TDJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.08819 TE10 CCLE Cell Line Gene CNV Profiles 1.0 1.90782 OELE CCLE Cell Line Gene Expression Profiles -1.0 -2.13474 GTEX-TSE9-0011-R11A-SM-3DB7N GTEx Tissue Sample Gene Expression Profiles 1.0 0.922241 PSMD13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59942 POMGNT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21545 LASP1NB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81368 layer IIIu of area 35r Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.70773 HAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3218 Gene expression (Transcription) Reactome Pathways 2024 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A6HO-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H2172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.868214 L3HYPDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31547 GSE188458_2_v_1_hydrogen peroxide_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CDK7_knockdown_138_GSE31534 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.82991 POLQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85922 ABL1_knockdown_137_GSE31534 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.48154 Oxygen HMDB Metabolites of Enzymes 1.0 null GTEX-RWS6-2326-SM-2XCB4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.902747 GTEX-OOBK-2126-SM-3LK5T GTEx Tissue Sample Gene Expression Profiles 1.0 2.24361 mediodorsal nucleus of thalamus_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.12754 GSE180147_0_v_1_itga5_human RummaGEO Gene Perturbation Signatures -1.0 null intrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null CALU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86877 GTEX-UTHO-0011-R2A-SM-3GIKC GTEx Tissue Sample Gene Expression Profiles 1.0 1.0418 intracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 496100462_PCx_dementia_TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.33477 GSE174498,GSE174500_2_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null ventrolateral prefrontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.947487 GSU DepMap CRISPR Gene Dependency 1.0 5.04039 DLX6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.2107 GTEX-U3ZH-1526-SM-4DXV1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.58515 IKZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.8878 MAP1LC3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71337 Uterus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null MSANTD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89872 intracellular part LOCATE Curated Protein Localization Annotations 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7879-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Stomach Smooth Muscle Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 0.832013 NCIH716 DepMap CRISPR Gene Dependency 1.0 3.20914 fallopian tube HPA Tissue Protein Expression Profiles 1.0 1.48468 transmembrane transport GO Biological Process Annotations 2015 1.0 null HCC1588 CCLE Cell Line Gene Expression Profiles -1.0 -1.45211 GBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.9557 CCDC14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58017 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70E-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WL46-0011-R1A-SM-3LK6M GTEx Tissue Sample Gene Expression Profiles 1.0 0.909545 RHNO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43878 ZNF358 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30203 ABL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3512 SG in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.979767 Mitochondrial proton-transporting ATP synthase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.07 MAP4K2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40374 OXSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83604 CTCF_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTSD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13223 Sarcoma_SARC_TCGA-X9-A971-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210655_3_v_0_cisplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null SLC25A25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8879 parataenial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.912141 U-2 OS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.875651 ATP2B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.23362 NT5C2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09917 DU 145 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.64761 NFATC4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.4492 Heteromeric SMAD protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.442 TFAP2A-17053090-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE127261_1_v_2_ezh2_human RummaGEO Gene Perturbation Signatures -1.0 null CEPT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12015 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4332-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3C7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19464 ELAC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13599 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A6MD-01A-41R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STAR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16331 SRP14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21263 Prostate adenocarcinoma_PRAD_TCGA-HC-A8D0-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null testis HPA Tissue Protein Expression Profiles 1.0 1.48468 ASTE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.57093 AK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4237 KIF3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80641 IGDCC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41634 HOP92 CCLE Cell Line Gene CNV Profiles -1.0 -1.36194 TUHR4TKB CCLE Cell Line Gene CNV Profiles -1.0 -1.46672 GSE88819_1_v_2_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null USP25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71062 mitochondrial part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.081997 CTCF_MCF-7_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUZ12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30196 FABP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.78243 inferolateral temporal cortex (area TEv, area 20)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.0576 HTATIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8938 SEC61A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54969 GTEX-XMD1-0526-SM-4AT4Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.937619 AGPAT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57895 GTEX-XYKS-2426-SM-4AT43 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07386 496100618_PCx_probable Alzheimer's disease_no TBI_86_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.44138 Bladder Urothelial Carcinoma_BLCA_TCGA-S5-A6DX-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH3255 CCLE Cell Line Gene CNV Profiles 1.0 1.67942 occipital pole, left, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.45705 RUNX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56027 TPSD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15142 EB2 CCLE Cell Line Gene Expression Profiles 1.0 2.05493 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A44B-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3359-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RYBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83938 ABCB10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6962 GTEX-NL3H-0011-R10A-SM-2I3E9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.864629 Brain Lower Grade Glioma_LGG_TCGA-S9-A6WQ-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU-398 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39887 KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.908915 Uterine Carcinosarcoma_UCS_TCGA-N5-A4RO-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 SMARCD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82676 mRNA_KLF4_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.828632 SP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41998 Uterine endometrium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Mucosa TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GTEX-WRHU-1126-SM-4E3I1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.901346 mRNA_EOMES_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null THAP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 60.3897 FIGNL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94237 Brain Lower Grade Glioma_LGG_TCGA-DB-A64S-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZDHHC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42194 UNC5CL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55219 SUM52PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.857675 SK-MEL-31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.14895 METAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69114 GTEX-RWSA-2426-SM-47JXR GTEx Tissue Sample Gene Expression Profiles 1.0 1.68637 KLHDC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33418 KLRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04204 Primary hematopoietic stem cells G-CSF-mobilized Female RO_01508 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.11806 locus ceruleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.875023 PRRX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.369 SKM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.36405 hsa-miR-101 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 TMCO6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46299 MHHNB11 CCLE Cell Line Gene Expression Profiles 1.0 1.6146 FGD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32226 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.049797 primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.40889 SK-MEL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -3.0007 CTCF_WERI-Rb-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer V of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.99972 EEF1AKMT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88869 FOSL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.9022 NUTM2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9786 FBN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52317 cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.048366 CLMP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24788 IGDCC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46293 MCF-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.837011 NFIC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.5714 CTCF_GM12868_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1437 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17864 Lung squamous cell carcinoma_LUSC_TCGA-66-2771-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gracile nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.75726 MNT JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.5617 ATF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43921 GTEX-NPJ7-0011-R2a-SM-2I3GF GTEx Tissue Sample Gene Expression Profiles 1.0 0.983819 GSE126621,GSE126920_1_v_0_dppa4_mouse RummaGEO Gene Perturbation Signatures -1.0 null parahippocampal gyrus, left, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.8644 INS-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.531 CTCF_GM19239_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mitochondrial large ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.579 EZH2 ENCODE Transcription Factor Targets 1.0 null dorsolateral prefrontal cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.67941 paraventricular nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.30147 Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A47N-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DETROIT 562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.975907 THUMPD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60769 polymorphic layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.879293 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RT-A6YA-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YL-A9WI-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null deep layers of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.82425 ventromedial hypothalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.49968 CTCF_HCT116_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CBR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08332 striatum_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.7445 Acute Myeloid Leukemia_LAML_TCGA-AB-2973-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null bed nucleus of stria terminalis, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.48406 interstitial nucleus of Cajal, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.74861 TNFRSF25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32239 dorsolateral prefrontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.855805 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE186005_1_v_2_klf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRCA1_DEPLETION_GDS2189_121_human_MCF10A mammary epithelial cells (MECs) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Meiotic prophase fetal germ cell_Fetal gonad_Human CellMarker Gene-Cell Type Associations 1.0 null SUV39H1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78883 TMEM60 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89422 ARL14EP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93577 PCCA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82611 hsa-miR-106a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAB2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38721 GSE183994_1_v_0_scml2_mouse RummaGEO Gene Perturbation Signatures 1.0 null ventrolateral prefrontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.0683 GGN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49481 KLF1 ChEA Transcription Factor Targets 1.0 null LCN10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07215 GTEX-XPT6-1626-SM-4B655 GTEx Tissue Sample Gene Expression Profiles 1.0 1.90259 ER-23166858-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ZNF234 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20234 GNG13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64333 CAKI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.961626 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null C11orf58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12955 P300-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rumen TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.837 JRK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72508 GTEX-XQ3S-2726-SM-4BOP2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.83994 CTCF_LNCaP clone FGC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Metabolism Reactome Pathways 2024 1.0 null 3-methylcrotonyl-CoA carboxylase deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.178 NCOR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.735 ABI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.63373 ATP1A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05511 CHEK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18123 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.67832 colon HPA Tissue Protein Expression Profiles 1.0 0.792556 PABPC1L2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88186 LYNX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24591 SNW1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33929 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5469-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HOXB13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94011 ERBB3_drugactivation_31_GDS4361 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.41132 HOXD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52224 CTRL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56373 OVMANA CCLE Cell Line Gene CNV Profiles -1.0 -1.7158 GTEX-UPK5-2126-SM-4JBJK GTEx Tissue Sample Gene Expression Profiles 1.0 1.04655 outer CP in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14628 ZNF446 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6775 DDX55 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.04935 PPM1M CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53034 Lung adenocarcinoma_LUAD_TCGA-91-6840-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_6252_KO_Pcgf1/Pcgf6_SRP269225 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 12.5358 SIVA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29925 RCOR1-19997604-NEURONS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null UPF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2626 GTEX-OXRO-0011-R9A-SM-3NB1X GTEx Tissue Sample Gene Expression Profiles 1.0 0.953013 LY2 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.868748 CDK11A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19507 ULBP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64885 CTCF_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12875_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null rostral division of OFCi (area 11) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.961044 lateral intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.539 NCI-H2171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.27321 JHUEM1 CCLE Cell Line Gene Expression Profiles -1.0 -1.55198 KMM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.919051 CTCF_GM12870_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null LEO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.43212 EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHID1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55783 temporal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.13694 PABIR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78785 blood GTEx Tissue Gene Expression Profiles -1.0 -1.34084 hippocampus (hippocampal formation)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.935444 olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.28541 organelle LOCATE Predicted Protein Localization Annotations 1.0 null spinalcordupper BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.926818 CTCF_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lung HPA Tissue Protein Expression Profiles 1.0 0.939579 HCE-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null H2AC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.43353 STAT4 MotifMap Predicted Transcription Factor Targets 1.0 null SMIM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01426 RHOD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93812 inorganic ion transmembrane transport GO Biological Process Annotations 2015 1.0 null ZNF736 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60448 20421987-TableS6 GeneSigDB Published Gene Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YL-A8SL-01B-21R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null laterodorsal subdivision of area 8 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.878207 hydrogen ion transmembrane transport GO Biological Process Annotations 2015 1.0 null GTEX-O5YT-0726-SM-3MJHA GTEx Tissue Sample Gene Expression Profiles 1.0 0.942808 HNRNPUL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00588 Acute Myeloid Leukemia_LAML_TCGA-AB-2971-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TUBB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49798 ACTC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88016 Pancreatic adenocarcinoma_PAAD_TCGA-F2-6880-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM12873_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mitochondrial inner membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.323075 GSE88819_1_v_4_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null HDAC2 ENCODE Transcription Factor Targets 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.64746 CTCF_MCF-7_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12874_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary motor cortex (area M1, area 4)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.4154 H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XLM4-1526-SM-4AT6D GTEx Tissue Sample Gene Expression Profiles 1.0 1.82999 eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RNOR-0826-SM-2TF5C GTEx Tissue Sample Gene Expression Profiles 1.0 0.869201 frontal pole, right, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.00798 REH COSMIC Cell Line Gene Mutation Profiles 1.0 null PPARG ChEA Transcription Factor Targets 1.0 null H3K27me3_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3C13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42201 GTEX-Q734-0326-SM-48U15 GTEx Tissue Sample Gene Expression Profiles 1.0 0.859115 AGFG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37219 cerebellar cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.845293 GTEX-XLM4-0011-R2B-SM-4AT5Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.938111 hsa-miR-130b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 Kidney renal papillary cell carcinoma_KIRP_TCGA-UZ-A9PJ-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7H7-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HUNS1 DepMap CRISPR Gene Dependency 1.0 12.9328 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4167-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AMBRA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73803 3-methylcrotonyl-CoA carboxylase complex, mitochondrial COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.091 COA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0397 Brain Lower Grade Glioma_LGG_TCGA-S9-A6TY-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10245467-mmc3.pdf-46-ZNF487_ZNF487 Rummagene Transcription Factor Associations 2026 1.0 null SLIRP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44164 Prostate adenocarcinoma_PRAD_TCGA-G9-6366-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KCTD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47706 ASMTL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14155 PARP2_KD_GSE43981_676_human_HepG2 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null DCAF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70951 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A7CZ-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FYTTD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68078 mitochondrial membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.348725 ion transport GO Biological Process Annotations 2015 1.0 null FAM171A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13654 Calvarium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.871 CTCF_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MRM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1509 Stat5b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.5134 GALNT11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8805 SMAD5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.8148 MIXL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.6323 SW1710 CCLE Cell Line Gene CNV Profiles -1.0 -1.42742 Lung adenocarcinoma_LUAD_TCGA-62-A46O-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SOX18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59313 thyroid BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.43468 GSE174498,GSE174500_3_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null NLGN4Y CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78852 ELK1::SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.6382 RAPGEFL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52986 GSE115395_2_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WFON-2026-SM-4LVMW GTEx Tissue Sample Gene Expression Profiles 1.0 1.51197 hippocampus (hippocampal formation)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03208 prednisolone_homo sapiens_gpl570_gse32962 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EWSR1-FLI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 111.2 SLC25A46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.83538 MAPKAPK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61766 HS604T CCLE Cell Line Gene Expression Profiles -1.0 -2.04477 RND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.20537 KASUMI2 CCLE Cell Line Gene CNV Profiles -1.0 -1.58367 IGLON5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44853 GSE201309_1_v_6_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null FOXH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04543 ENTPD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46569 organelle membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.055883 SAP30 ENCODE Transcription Factor Targets 1.0 null D341MED CCLE Cell Line Gene Expression Profiles 1.0 1.65446 CDCA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99897 intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 hsa-miR-4295 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 DPY19L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22615 CHSY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37809 FHOD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37771 MARVELD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50877 Mitotic arrest phase fetal germ cell_Fetal gonad_Human CellMarker Gene-Cell Type Associations 1.0 null NCI-H2228 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.962885 Kidney renal papillary cell carcinoma_KIRP_TCGA-DZ-6135-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SUCS-1326-SM-4DM5T GTEx Tissue Sample Gene Expression Profiles 1.0 1.9112 GTEX-S95S-1126-SM-4B64E GTEx Tissue Sample Gene Expression Profiles 1.0 2.1201 anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.940265 KLHL18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70287 TJP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88433 SHI1 DepMap CRISPR Gene Dependency 1.0 4.90675 Sarcoma_SARC_TCGA-3B-A9HQ-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5085-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-V1D1-0526-SM-4JBGW GTEx Tissue Sample Gene Expression Profiles 1.0 0.951723 ETV2::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.8036 ATP5MGL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21046 Kidney Chromophobe_KICH_TCGA-KN-8436-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE247764_5_v_2_nell2_mouse RummaGEO Gene Perturbation Signatures 1.0 null RAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64315 CRB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29215 59M CCLE Cell Line Gene Expression Profiles -1.0 -1.47966 CA3 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.21189 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Aerobic respiration and respiratory electron transport Reactome Pathways 2024 1.0 null SETDB1_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PIK3R4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99065 PRKX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28497 VMAC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55722 JIMT1 CCLE Cell Line Gene CNV Profiles -1.0 -2.59404 EMX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.1525 mitochondrion GO Cellular Component Annotations 2015 1.0 null KYM1 DepMap CRISPR Gene Dependency 1.0 3.68057 integral component of membrane GO Cellular Component Annotations 2015 1.0 null anterior orbital gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.843808 PMC6781638__F4 PFOCR Pathway Figure Associations 2024 1.0 null ZBTB12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15133 H3K4me1_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE199255,GSE199356_3_v_2_pds5a_mouse RummaGEO Gene Perturbation Signatures -1.0 null METTL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96023 NUP43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5868 Edinger-Westphal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.930568 Pancreatic adenocarcinoma_PAAD_TCGA-IB-7893-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TLX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.548 inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15524 cuneate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.980127 Organelle envelope COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 Prostate adenocarcinoma_PRAD_TCGA-G9-6347-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HOXC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43858 SMG6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50819 PRR14L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83665 cingulum bundle, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.77504 GSE112962,GSE112963_2_v_1_ddx5_human RummaGEO Gene Perturbation Signatures 1.0 null RASL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13551 organelle inner membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 mRNA_GADD45A_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null anterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.02521 STAT1 JASPAR Predicted Transcription Factor Targets 1.0 null intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.04198 Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GNPDA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66227 AVL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.15831 substantia innominata, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.866954 DTX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6097 GSE198165,GSE198166_0_v_4_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XV7Q-1026-SM-4BRVR GTEx Tissue Sample Gene Expression Profiles 1.0 0.870043 Lung squamous cell carcinoma_LUSC_TCGA-43-7657-01A-31R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-Q734-0226-SM-48U1A GTEx Tissue Sample Gene Expression Profiles 1.0 0.956596 G121 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.14895 CTCF_A549_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null Amyotrophic lateral sclerosis KEGG Pathways 2026 1.0 null RT4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.836106 M07E DepMap CRISPR Gene Dependency 1.0 2.30853 CTCF_HepG2_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral tuberal nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.24501 PDSS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86605 SNU601 DepMap CRISPR Gene Dependency 1.0 10.4113 WASHC2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2585 HS606T CCLE Cell Line Gene Expression Profiles -1.0 -1.68818 Central nervous system lipoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.741 membrane part GO Cellular Component Annotations 2015 1.0 null CUL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4263 ZNF615 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03883 B3GALT9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22986 GTEX-X585-0011-R4B-SM-46MVH GTEx Tissue Sample Gene Expression Profiles 1.0 1.10338 H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KRBA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8879 HCC1833 CCLE Cell Line Gene Expression Profiles -1.0 -2.69569 H3K9me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RNOR-0426-SM-2TF4U GTEx Tissue Sample Gene Expression Profiles 1.0 0.855497 NOP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01264 single-organism cellular process GO Biological Process Annotations 2015 1.0 null ARHGEF9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59209 layer II of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.01492 H3K27me3_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CELF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08673 SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18239 POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null methylcrotonoyl-CoA carboxylase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.958 dorsal cochlear nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03912 MEF2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21937 dactinomycin_mus musculus_gpl1261_wild type_gds2456 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-43-5668-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ARMC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20539 GTEX-X261-3226-SM-3NMC3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.888872 RAX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12917 NAA16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73448 GSE154246_2_v_0_haspin_mouse RummaGEO Gene Perturbation Signatures -1.0 null DELE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83602 NPAS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21727 GTEX-XLM4-2926-SM-4AT59 GTEx Tissue Sample Gene Expression Profiles 1.0 0.827873 Brain Lower Grade Glioma_LGG_TCGA-P5-A72W-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-NL3H-0011-R5a-SM-2I3GB GTEx Tissue Sample Gene Expression Profiles 1.0 0.960729 FOXH1-21741376-EPCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null IV, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.996188 GTEX-X638-0326-SM-47JY1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.978531 SLC25A15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24747 RAB40A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99315 TFAP2A ChEA Transcription Factor Targets 1.0 null NAGA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98583 CELSR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90182 Cytochrome c oxidase subunit VIII/photosystem I reaction centre subunit IX InterPro Predicted Protein Domain Annotations 1.0 null CTSC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61897 SATB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.18576 KNS81 CCLE Cell Line Gene CNV Profiles -1.0 -1.46399 mitochondrial inner membrane GO Cellular Component Annotations 2025 1.0 null COX7A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16021 Sarcoma_SARC_TCGA-FX-A48G-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-519d TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 Sarcoma_SARC_TCGA-DX-A7ER-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WZTO-3026-SM-3NMA2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.852291 GTEX-PVOW-2726-SM-48TCA GTEx Tissue Sample Gene Expression Profiles 1.0 0.919183 496100412_FWM_possible Alzheimer's disease_TBI_87_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.27163 adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.434899 Thermogenesis KEGG Pathways 2026 1.0 null KYSE-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05795 sirolimus_mus musculus_gpl1261_gse5332 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null UACC257 DepMap CRISPR Gene Dependency 1.0 3.52318 GTEX-V1D1-2126-SM-4JBH4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.74034 ZNF649 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17967 mammillary body, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.99376 Disease of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.821 olfactorybulb BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.854278 Sperm flagellum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.897 TRMT44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73387 C1orf35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30034 mRNA_TCF3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null TPR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22721 GTEX-WL46-0926-SM-3LK7T GTEx Tissue Sample Gene Expression Profiles 1.0 1.16966 GTEX-QVUS-0011-R6A-SM-3GACX GTEx Tissue Sample Gene Expression Profiles 1.0 0.913338 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M6-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Mitochondrial small ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.668 TPST2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56041 WDR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12395 ZNF324 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.0446 ZNF853 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47111 CTCF_GM12872_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null INKA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84452 Brain Lower Grade Glioma_LGG_TCGA-WH-A86K-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.07 Prostate adenocarcinoma_PRAD_TCGA-KK-A6E6-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UBR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81305 Rectal Mucosa Donor 31 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.95164 CTCF_MCF-7_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null mitochondrial part GO Cellular Component Annotations 2015 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7418-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100611_FWM_no dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.0124 PTK7_KD_GSE50138_674_human_H1299 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null FADU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.55588 UBE2G1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.04511 VZ in septal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.942025 GTEX-S33H-2326-SM-2XCB3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01292 PMC4082627-12864_2014_6197_MOESM8_ESM.xlsx-GATA3_only-Nearest_Ensembl_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5199-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null INTS15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33066 RAD21_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCDC115 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.20875 inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.924999 L363 CCLE Cell Line Gene CNV Profiles -1.0 -1.57553 Water HMDB Metabolites of Enzymes 1.0 null GSE174498,GSE174500_5_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_GM12864_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null APOBEC3H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0602 Uterine Carcinosarcoma_UCS_TCGA-N5-A4RS-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X585-0011-R8A-SM-46MUX GTEx Tissue Sample Gene Expression Profiles 1.0 1.10718 TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null ABHD14B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49069 ANHX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2981 KLF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 80.2325 GTEX-QEG4-0126-SM-48TZE GTEx Tissue Sample Gene Expression Profiles 1.0 2.17753 mitochondrial part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 ZNF343 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92054 EIF3D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56231 GTEX-N7MS-2526-SM-2D7W3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.853268 RNF112 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23301 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LA-01A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13213 cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null Alzheimer disease KEGG Pathways 2026 1.0 null KLF1-20508144-FETAL-LIVER-ERYTHROID-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null COV318 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.836106 H4C9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23481 L540 CCLE Cell Line Gene Expression Profiles -1.0 -1.50948 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81N-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null respiratory chain complex IV GO Cellular Component Annotations 2023 1.0 null 19139136-TableS2 GeneSigDB Published Gene Signatures 1.0 null amygdaloid complex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.847836 ARGLU1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17048 GTEX-N7MS-0011-R8a-SM-2YUMK GTEx Tissue Sample Gene Expression Profiles 1.0 0.932232 H3K9me3_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF ENCODE Transcription Factor Targets 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8434-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.85269 NR1D2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.9868 PALM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15885 anterior (rostral) cingulate (medial prefrontal) cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.90989 Brain Lower Grade Glioma_LGG_TCGA-S9-A6WO-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE240439_1_v_2_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null IFT52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32121 c2c12 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.13508 orbital frontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.834034 CRK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.05471 HMX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16468 769-P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.57894 MKNK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.89495 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRDT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04868 PCDH8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01604 WDR82 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56877 GTEX-R55D-0126-SM-48FEL GTEx Tissue Sample Gene Expression Profiles 1.0 1.73266 MRPL22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46812 GTEX-RUSQ-2126-SM-47JXK GTEx Tissue Sample Gene Expression Profiles 1.0 1.71589 AHR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8502 cerebellar cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.4897 Acute Myeloid Leukemia_LAML_TCGA-AB-2986-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LEPROT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51776 PATZ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60777 striatum_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.31491 VEGFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4993 Adrenocortical carcinoma_ACC_TCGA-OR-A5KW-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A60L-01A-12R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBC1D9B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06743 organelle part GO Cellular Component Annotations 2015 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A59T-01A-21R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMAD2 ChEA Transcription Factor Targets 1.0 null mRNA_EP400_22196727 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null GSE174498,GSE174500_5_v_7_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-7525-01A-31R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NR6A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 5.15296 Cellular responses to stimuli Reactome Pathways 2024 1.0 null VHL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70521 CTCF_GM12873_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null heme-copper terminal oxidase activity GO Molecular Function Annotations 2015 1.0 null CSTF2T CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05404 cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 proton-transporting ATP synthase complex, coupling factor F(o) COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.318 Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3472-01A-01R-1193-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GALNS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23769 MAN1A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7068 BAG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0622 hsa-miR-519b-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 H3K27me3_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-4424-01A-22R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T5JC-1526-SM-4DM68 GTEx Tissue Sample Gene Expression Profiles 1.0 0.89532 KLF1-20508144-FETAL-LIVER-ERYTHROID-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-X5EB-0426-SM-46MVY GTEx Tissue Sample Gene Expression Profiles 1.0 0.969873 SSBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71114 TAF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33434 H3K27me3_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -3.31006 GTEX-PVOW-2626-SM-32PL8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.26386 ETV5::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.2539 VZ in subcallosal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.894914 MRPL35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88123 ZEB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.496 UBE2D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17068 SUDHL10 CCLE Cell Line Gene Expression Profiles 1.0 1.5153 SMAD3-18955504-HaCaT-human ChEA Transcription Factor Binding Site Profiles 1.0 null CTCF_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100562_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.54796 EHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.3637 TBCD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15795 MRPL49 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.16078 Disease Progression HuGE Navigator Gene-Phenotype Associations 1.0 null PMC8528285-pbio.3001085.s010.xlsx-Fig_S8D-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_WT_3T3_ONLY_1626_GENES_MNT Rummagene Transcription Factor Associations 2026 1.0 null ZNF581 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80177 GSE201309_1_v_2_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null ZNF829 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42624 METTL25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36561 RAD50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16394 organelle inner membrane GO Cellular Component Annotations 2015 1.0 null SEMA4F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96289 FOXP1 ChEA Transcription Factor Targets 1.0 null GSE157383_3_v_2_abemaciclib_human RummaGEO Drug Perturbation Signatures 1.0 null organelle inner membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.309613 H3K9me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RNPC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3886 DMS53 DepMap CRISPR Gene Dependency 1.0 4.02819 REST ChEA Transcription Factor Targets 1.0 null GSE120612_6_v_3_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null RFX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.7639 Skin Cutaneous Melanoma_SKCM_TCGA-FR-A726-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MM127 DepMap CRISPR Gene Dependency 1.0 2.03578 CTCF_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.03 MDAMB415 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.975477 MUTZ8 DepMap CRISPR Gene Dependency 1.0 2.33354 SEPTIN10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37088 Generic Transcription Pathway Reactome Pathways 2024 1.0 null GSE88819_0_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ARHGEF17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30083 RMC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48836 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YS-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PARP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56103 GTEX-XGQ4-0226-SM-4GIDS GTEx Tissue Sample Gene Expression Profiles 1.0 0.859759 cation transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null GTEX-V955-1726-SM-4JBHF GTEx Tissue Sample Gene Expression Profiles 1.0 1.0704 GTEX-PWCY-1326-SM-48TCU GTEx Tissue Sample Gene Expression Profiles 1.0 1.25673 GNAO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49127 ZNF691 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42096 H3K9me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OHPM-0326-SM-33HCA GTEx Tissue Sample Gene Expression Profiles 1.0 0.861659 PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-20b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 NPFF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91819 CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-1017-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null C17orf58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39327 ChIP_SUZ12_18974828 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null PDCD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36035 GTEX-XMD1-2826-SM-4AT5F GTEx Tissue Sample Gene Expression Profiles 1.0 0.883936 GTEX-X4XX-0926-SM-46MV7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05171 SMIM12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02066 SLC19A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08714 GTEX-RNOR-0011-R7A-SM-2TF4V GTEx Tissue Sample Gene Expression Profiles 1.0 1.2804 arcuate nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.51076 MM.1S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.56497 hsa-miR-519c-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 CA2 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.49951 KMH-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-SNMC-1026-SM-4DM7K GTEx Tissue Sample Gene Expression Profiles 1.0 1.87396 FOXO1::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.4816 ZNF530 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 121.541 KPTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56879 GTEX-Q734-0626-SM-2I3EF GTEx Tissue Sample Gene Expression Profiles 1.0 1.08743 Rectum adenocarcinoma_READ_TCGA-G5-6572-02A-12R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAPK13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61472 ICE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.43479 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I9-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE88819_1_v_12_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null KCNN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92667 Adrenocortical carcinoma_ACC_TCGA-OR-A5JO-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CA11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32543 lateral hypothalamic area, tuberal part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05966 HSPA1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30301 GTEX-OXRL-2126-SM-3NM98 GTEx Tissue Sample Gene Expression Profiles 1.0 2.12005 GSE199255,GSE199356_6_v_2_pds5a_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null BAIAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18498 EPOP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74504 CNOT6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43729 PRR13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66205 GPR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64885 epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050564 CLDN34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16156 GTEX-P4QS-2126-SM-3NMCF GTEx Tissue Sample Gene Expression Profiles 1.0 1.94761 NIF3L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.76679 KANK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.07627 organelle envelope COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Kidney Chromophobe_KICH_TCGA-KN-8423-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LBHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06122 NXT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36633 GTEX-NPJ8-0011-R6a-SM-2HMKB GTEx Tissue Sample Gene Expression Profiles 1.0 0.933857 PPM1F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76344 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A5Y0-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-130a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 COLO680N CCLE Cell Line Gene CNV Profiles 1.0 1.70115 ETV1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.9653 MYL12A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64777 MRPL50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50879 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor GO Molecular Function Annotations 2015 1.0 null SETDB1 ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-96-A4JK-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MISP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79202 HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.919051 GTEX-TKQ1-0926-SM-4DXU2 GTEx Tissue Sample Gene Expression Profiles 1.0 2.02432 PHOX2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.0384 Lung squamous cell carcinoma_LUSC_TCGA-46-3769-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRTC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42581 NTHL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04105 GLIS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72783 ZNF518B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66288 Rectum adenocarcinoma_READ_TCGA-AG-3591-01A-01R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRPSAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29884 CTCF_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null AGAP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57787 CTCFL_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.05928 Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COGAR359 DepMap CRISPR Gene Dependency 1.0 2.52053 BBS10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63317 GTEX-N7MT-0011-R3a-SM-2I3GC GTEx Tissue Sample Gene Expression Profiles 1.0 0.956711 NCI-H2030 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.896926 envelope COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 ALAS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.01487 NCIH1694 CCLE Cell Line Gene CNV Profiles 1.0 2.19911 GSE202603_1_v_2_bhlhe40_mouse RummaGEO Gene Perturbation Signatures -1.0 null ventrolateral prefrontal cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.86354 cytoplasmic part LOCATE Curated Protein Localization Annotations 1.0 null ITGA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7327 FAU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03947 CTCF_GM19240_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Respiratory chain complex III COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.587 TSSK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98452 superficial layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00849 SPIRE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38714 Sarcoma_SARC_TCGA-K1-A3PN-02A-11R-A22K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EEF1AKMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98657 GTEX-X4XX-2926-SM-3NMB1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12863 DCAF15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31059 HAPLN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96248 GTEX-XMD1-0011-R8A-SM-4AT48 GTEx Tissue Sample Gene Expression Profiles 1.0 1.3571 OCI-M2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.979153 Skeletal Muscle Female Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 0.871215 UPF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.12466 ZNF682 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81137 GTEX-V955-1926-SM-4KL1L GTEx Tissue Sample Gene Expression Profiles 1.0 1.67237 GTEX-T6MN-2026-SM-4DM7L GTEx Tissue Sample Gene Expression Profiles 1.0 2.08581 OVCAR5 CCLE Cell Line Gene CNV Profiles -1.0 -1.39424 respiratory chain COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.346071 GTEX-QEL4-0526-SM-3GIJ4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.19186 C8orf33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53003 ABCG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51013 FOXP1-21924763-HESC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null ZSCAN10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31775 ISX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.2672 GTEX-RU72-0011-R6A-SM-2TF71 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06931 ZSCAN21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.075 PTBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19911 GNB5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11103 KMS-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01287 COLO680N CCLE Cell Line Gene Expression Profiles -1.0 -1.46048 NCI-H2803 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19388 Sarcoma_SARC_TCGA-DX-A7ET-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH526 DepMap CRISPR Gene Dependency 1.0 2.44368 Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUR-01A-21R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF257 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 66.1298 PHF14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09595 GTEX-WWYW-3026-SM-3NB36 GTEx Tissue Sample Gene Expression Profiles 1.0 1.42125 intracellular organelle LOCATE Curated Protein Localization Annotations 1.0 null LPIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71251 DGAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49233 GSE201309_5_v_7_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WZTO-2826-SM-3NM8P GTEx Tissue Sample Gene Expression Profiles 1.0 1.09595 GSE88819_7_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_GM12871_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sleep disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.821 IKZF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.31737 mitochondrial inner membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GTEX-UTHO-0726-SM-3GAEN GTEx Tissue Sample Gene Expression Profiles 1.0 1.35047 Adrenocortical carcinoma_ACC_TCGA-OR-A5KO-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Silver ion transmembrane transporter complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.592 ANKRD30A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35754 Kidney Chromophobe_KICH_TCGA-KN-8432-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042659 WM2664 CCLE Cell Line Gene Expression Profiles -1.0 -2.07141 TP73 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.3437 NT5C3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95497 GSE241701_2_v_0_daxx_mouse RummaGEO Gene Perturbation Signatures -1.0 null ATP5F1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03247 posteroventral (inferior) parietal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.886945 GSE152441,GSE152442_7_v_2_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null cdkn1b_18180298_3t3_lof_mouse_gpl1261_gse9161 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.783475 LETMD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8465 WFDC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54207 CTCF_GM12865_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF638 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56983 CHEK1_knockdown_136_GSE31534 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.68526 inferior occipital gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02325 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D4-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE152441,GSE152442_7_v_5_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null COR-L47 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.91244 SP110 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37212 GSE152441,GSE152442_1_v_5_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null hippocampus (hippocampal formation)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03839 Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A9DC-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE196259_2_v_0_gcm1_human RummaGEO Gene Perturbation Signatures -1.0 null cerebellar cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.871171 BT-549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05795 TP53 Regulates Metabolic Genes Reactome Pathways 2024 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A6AQ-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMYD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34159 localization GO Biological Process Annotations 2015 1.0 null HT1197 CCLE Cell Line Gene Expression Profiles -1.0 -1.5452 NCI-H1299 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04879 posteroventral (inferior) parietal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.828417 Acute Myeloid Leukemia_LAML_TCGA-AB-2879-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IQGAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.88009 membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null PMC4082627-12864_2014_6197_MOESM8_ESM.xlsx-GATA3_only-Gene_Name_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-NL3H-0011-R11A-SM-2I3E6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.40439 MZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.941072 SMO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.87474 GSE183994_3_v_0_scml2_mouse RummaGEO Gene Perturbation Signatures 1.0 null RRN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88206 CTCF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3320-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-NPJ8-0011-R1a-SM-33HCB GTEx Tissue Sample Gene Expression Profiles 1.0 1.29629 ZNF302 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4329 posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.27029 FBXO9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49506 CTCF_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAU2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70755 CTCF_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-AF-3911-01A-01R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-5280-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TENM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30462 Brain Lower Grade Glioma_LGG_TCGA-S9-A7R8-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.6557 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_2_FIGLA Rummagene Transcription Factor Associations 2026 1.0 null RAB35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.737 TP53 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.4702 RAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17238 ZNF624 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76894 TSC22D3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69558 tail of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04425 dentate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.947388 Cus cation efflux complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.592 COPE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.87667 HCC2935 DepMap CRISPR Gene Dependency 1.0 2.65882 Perturb_6380_KO_Snf5_SRP271283 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -8.83342 PPP1R8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23604 TTC21B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30677 U138MG CCLE Cell Line Gene CNV Profiles -1.0 -2.17297 SYT11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40643 pituitary GTEx Tissue Gene Expression Profiles 1.0 1.76385 NEUROD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42524 Respirasome COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 PPP1R13L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44994 SPPL2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.24676 hsa-miR-20a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GTEX-SNMC-1326-SM-2XCFK GTEx Tissue Sample Gene Expression Profiles 1.0 0.926374 membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 GTEX-RN64-2326-SM-48FDW GTEx Tissue Sample Gene Expression Profiles 1.0 1.69658 stratum radiatum of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.20807 496100466_PCx_probable Alzheimer's disease_no TBI_89_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.78144 Internal female genital organ TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 intracellular membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null PAPSS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0682 DROSHA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90776 GTEX-XBEC-0126-SM-4GIDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.93109 Nrf-1 MotifMap Predicted Transcription Factor Targets 1.0 null Respiratory chain complex IV COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.971 ZNF783 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.46874 primary motor cortex (area M1, area 4)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.78546 16618722-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.216672 METTL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78578 H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NOLC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81065 HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF140 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 60.4125 MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.962313 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AG-06A-31R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE234637_2_v_0_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13831 TTC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35869 mRNA_NRIP1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null NDST2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05848 ROR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53265 GSE88819_1_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null KDM5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88617 G44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.888628 C10 DepMap CRISPR Gene Dependency 1.0 3.67825 ZNF597 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00691 cellular process GO Biological Process Annotations 2015 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2919-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LOUNH91 CCLE Cell Line Gene CNV Profiles -1.0 -1.35771 MAVER1 DepMap CRISPR Gene Dependency 1.0 2.22269 RNF166 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.10858 SMAD3 ChEA Transcription Factor Targets 1.0 null NBEAL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37733 HSPG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3176 SMC1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88292 DACT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19977 hsa-miR-548t TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 Cytoprotection by HMOX1 Reactome Pathways 2024 1.0 null CTCF_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VJYA-1426-SM-4KL1Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.65114 ZNF710 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7631 hippocampus (hippocampal formation)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.933126 Brain Lower Grade Glioma_LGG_TCGA-P5-A780-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null kidney HPA Tissue Protein Expression Profiles 1.0 0.939579 GTEX-N7MT-1226-SM-2D7W4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.865685 LRRC45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71063 HKA1 DepMap CRISPR Gene Dependency 1.0 2.22445 RNF135 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71105 JURKAT CCLE Cell Line Gene Expression Profiles 1.0 1.44287 Urinary system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 CP in retrosplenial cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.77321 OV56 CCLE Cell Line Gene Expression Profiles 1.0 1.72164 mRNA_TCF3_20139965 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null inorganic cation transmembrane transport GO Biological Process Annotations 2015 1.0 null Brain Lower Grade Glioma_LGG_TCGA-RY-A83Z-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MEN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54711 ADCY3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65374 RS411 CCLE Cell Line Gene Expression Profiles 1.0 1.87914 GTEX-R55F-0011-R8A-SM-2TF4F GTEx Tissue Sample Gene Expression Profiles 1.0 1.03862 K029AX CCLE Cell Line Gene CNV Profiles -1.0 -1.5087 T3M4 CCLE Cell Line Gene Expression Profiles -1.0 -2.07503 heart GTEx Tissue Gene Expression Profiles 1.0 0.853548 Sarcoma_SARC_TCGA-DX-A7EI-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SGSM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59714 ADAM15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39728 MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null intracellular organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 NKX1-2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32713 orbital frontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.11189 ZNF701 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 97.8946 GTEX-RWSA-0726-SM-2XCBE GTEx Tissue Sample Gene Expression Profiles 1.0 0.929694 ANXA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7626 caudal group of intralaminar nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.93271 MKX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03541 posteroventral (inferior) parietal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.93731 Brain Lower Grade Glioma_LGG_TCGA-DU-6407-02B-11R-A36H-07,TCGA-DU-6407-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SF268 CCLE Cell Line Gene CNV Profiles 1.0 1.64463 SIN3A-21632747-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null TRIB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92384 SPTLC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70369 cerebellar cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.5333 G96 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.828632 GTEX-S7SE-0326-SM-4AT5Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.96235 CREB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.9572 spinal (inferior) vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19738 GTEX-PW2O-1426-SM-48TCD GTEx Tissue Sample Gene Expression Profiles 1.0 2.50806 orbital frontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.70186 KIAA2026 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89814 SETD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75208 THEM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72522 LSR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39569 Adrenocortical carcinoma_ACC_TCGA-OR-A5L6-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE212312_2_v_3_fbxw7_human RummaGEO Gene Perturbation Signatures 1.0 null HOP-92 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.68117 CTAGE9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42332 Septic Shock_Whole blood_GSE9692 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.56557 subcallosal cingulate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.62165 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RV-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hippocampus (hippocampal formation)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.855314 oxidoreductase activity GO Molecular Function Annotations 2015 1.0 null CTCF_GM12866_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VUSG-2226-SM-4KKZO GTEx Tissue Sample Gene Expression Profiles 1.0 1.40838 TC-YIK COSMIC Cell Line Gene Mutation Profiles 1.0 null C12orf43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4751 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.60801 ISHIKAWAHERAKLIO02ER CCLE Cell Line Gene Expression Profiles -1.0 -2.33279 organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 PBRM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62681 GTEX-S7PM-0626-SM-4AD4Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.80221 PMC6781638__F4 PFOCR Pathway Figure Associations 2023 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.71237 mitochondrial membrane GO Cellular Component Annotations 2015 1.0 null RCOR1 ChEA Transcription Factor Targets 1.0 null Mesothelioma_MESO_TCGA-MQ-A6BN-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.962313 NUDT22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46131 DHX57 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67382 Gitter cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.087 METTL18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23139 GTEX-X4XX-0011-R2A-SM-3P623 GTEx Tissue Sample Gene Expression Profiles 1.0 0.933074 temporal pole, left, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.30911 GNB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93607 Parkinson disease KEGG Pathways 2026 1.0 null MDAMB415 DepMap CRISPR Gene Dependency 1.0 2.1721 NXPE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30472 MRPS17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96005 JL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.67472 ventrolateral prefrontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.13964 GTEX-Q734-1426-SM-48TZQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.17592 facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.972283 Lung squamous cell carcinoma_LUSC_TCGA-66-2766-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE198165,GSE198166_9_v_4_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null PAQR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8187 Mitochondrial membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 TFEC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.5142 primary auditory cortex (core)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.830788 DTD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94929 496100336_TCx_no dementia_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.09416 hsa-miR-19a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039747 GTEX-RN64-0726-SM-48FCV GTEx Tissue Sample Gene Expression Profiles 1.0 0.97593 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041509 MARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.95759 TTLL11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82989 ZNF418 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.5615 transport GO Biological Process Annotations 2015 1.0 null GTEX-XMD1-0011-R5A-SM-4AT47 GTEx Tissue Sample Gene Expression Profiles 1.0 0.951248 H2AFZ ENCODE Transcription Factor Targets 1.0 null lateral reticular nucleus (principal part) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.22723 inner CP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.858359 stratum radiatum of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.22808 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JJ-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OIZI-0126-SM-3NB13 GTEx Tissue Sample Gene Expression Profiles 1.0 1.53667 CC2D1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63004 cell part LOCATE Curated Protein Localization Annotations 1.0 null NEURL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87683 RUNX2-22187159-PCA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null PTGR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30306 Cytochrome c oxidase, subunit 8 InterPro Predicted Protein Domain Annotations 1.0 null PMC10824666-43018_2023_699_MOESM2_ESM.xls-Suppl_Table_S4-AM-1882_AUC_vs_Gene_Expression_PRISM_Breast_and_Ovarian_Cancer_Cell_lines_n_58_PRDM6 Rummagene Transcription Factor Associations 2026 1.0 null primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.37969 TIA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42744 GTEX-X4XX-0011-R1B-SM-3P622 GTEx Tissue Sample Gene Expression Profiles 1.0 0.88563 GSE149264,GSE149267_4_v_1_trp53_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-T6MN-0011-R11A-SM-32QOX GTEx Tissue Sample Gene Expression Profiles 1.0 0.964974 ZNF652 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.833 TPM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.52953 PDCD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71534 GTEX-S95S-1226-SM-4GICG GTEx Tissue Sample Gene Expression Profiles 1.0 1.46637 vomeralnasalorgan.VMO. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.35996 GTEX-T8EM-0126-SM-4DM5R GTEx Tissue Sample Gene Expression Profiles 1.0 2.07095 mRNA_ASCL2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null WDR45B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.61248 HENMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39744 RPS28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17592 GTEX-P44H-0226-SM-2XCEU GTEx Tissue Sample Gene Expression Profiles 1.0 0.83018 GSE216988,GSE216989_0_v_1_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null Acquired Immunodeficiency Syndrome HuGE Navigator Gene-Phenotype Associations 1.0 null ZNF121 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55748 NAA40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.71521 POU5F1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71788 PANC1005 DepMap CRISPR Gene Dependency 1.0 6.54484 B4GALT5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69238 Sarcoma_SARC_TCGA-DX-A7EL-01A-12R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SEMA4D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34241 CTCF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55C-1426-SM-48FED GTEx Tissue Sample Gene Expression Profiles 1.0 1.77267 X, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.88054 SG in dysgranular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.94253 FUS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56861 GALNT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89371 intracellular part GO Cellular Component Annotations 2015 1.0 null PARP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68379 GTEX-X4XX-0011-R11A-SM-46MWQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.33094 Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7837-01A-11R-2139-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE140576_0_v_2_plag1_mouse RummaGEO Gene Perturbation Signatures 1.0 null C1GALT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36855 IZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.872499 Prostate adenocarcinoma_PRAD_TCGA-HC-A76X-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TMCO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81012 RCOR1-19997604-NEURONS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null NIBAN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11975 CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HT-29 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.962313 ZNF777 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3612 Prostate adenocarcinoma_PRAD_TCGA-HC-A6HX-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OSC-19 COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 hsa-miR-301a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 CPZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39658 OV-90 COSMIC Cell Line Gene Mutation Profiles 1.0 null SOX9-26525672-CHIP-SEQ-HEART-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-T6MN-0011-R5A-SM-32QPD GTEx Tissue Sample Gene Expression Profiles 1.0 0.922521 NUDT16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.54407 cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.72711 dorsolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.29579 MAX::MYC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.4762 PK-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.837011 E2F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.1138 SULT1C4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02975 inner CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.50712 mRNA_KLF4_18264089 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BOP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84631 TGFBR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91576 ADNP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.04737 Kidney Chromophobe_KICH_TCGA-KN-8426-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ENDOU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82452 SAR1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.113 GTEX-N7MS-0126-SM-3TW8O GTEx Tissue Sample Gene Expression Profiles 1.0 2.04967 Adrenocortical carcinoma_ACC_TCGA-OR-A5LA-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FBXO5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98298 SUCLG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65753 TE-6 COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 FAM162A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3132 H3K4me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null C12orf29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86576 HCC2302 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39887 KMS-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.14895 Acute Myeloid Leukemia_LAML_TCGA-AB-2955-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null rostral (anterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.17704 RBM18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60138 GTEX-RM2N-1326-SM-48FCW GTEx Tissue Sample Gene Expression Profiles 1.0 1.79632 posteroventral (inferior) parietal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.947487 Nkx2-1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.9772 primary auditory cortex (core)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.34967 PACS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40676 Gastrointestinal tract TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GTEX-XGQ4-0326-SM-4GIEE GTEx Tissue Sample Gene Expression Profiles 1.0 1.08377 LBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.5099 MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.80468 NUCB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90326 subcallosal cingulate gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.00185 THOP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11508 GSE123943_4_v_0_sox1_human RummaGEO Gene Perturbation Signatures 1.0 null HLA-DQB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32092 NCIH28 CCLE Cell Line Gene CNV Profiles -1.0 -1.43938 HOXD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40652 PCMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30697 20208059-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null COLO 680N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39887 Mitochondrial envelope COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 Acute Myeloid Leukemia_LAML_TCGA-AB-2859-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral portion of the shell Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.836832 cortico-medial group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1895 H3K9me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5JE-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TIGD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15069 medial group of nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.21792 SIN3A ChEA Transcription Factor Targets 1.0 null TSPAN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75252 rostral group of intralaminar nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.25381 NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39887 PUS7L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8546 SREBF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.5749 SERF1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51337 CTCF_GM12864_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KIJK DepMap CRISPR Gene Dependency 1.0 4.13931 GSE207514,GSE207515_2_v_3_acetylcysteine_human RummaGEO Drug Perturbation Signatures 1.0 null 496100489_HIP_possible Alzheimer's disease_no TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.35204 SHSY5Y CCLE Cell Line Gene Expression Profiles 1.0 1.96497 HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04879 TSPAN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.96924 endometrium HPA Tissue Protein Expression Profiles 1.0 1.48468 H2AC17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52059 496100396_HIP_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.78906 mitochondrion COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4837-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38033 ZNF233 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91112 PPARG-20887899-3T3-L1 PREADIPOCYTE CELLS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null layer IIIu of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08938 CCNB1IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32531 electron carrier activity GO Molecular Function Annotations 2015 1.0 null Body mass index GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.739794 496100577_FWM_probable Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.10724 ventrolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04609 mRNA_NR2F2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051389 G84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05966 PMC8571097-41588_2021_941_MOESM3_ESM.xlsx-Supplementary_Table_2-Supplementary_Table_2_List_of_KMT2A_fusion_oncoprotein_target_genes_in_each_sample_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null SKNDZ CCLE Cell Line Gene CNV Profiles -1.0 -1.43293 PITPNM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10412 primary auditory cortex (core)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.0497 Acute Myeloid Leukemia_LAML_TCGA-AB-2898-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TOE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45118 FNDC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.40688 PAX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17526 MLLT11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91003 JUND ENCODE Transcription Factor Targets 1.0 null Omegae TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.952 Mitochondrion COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 GTEX-OXRO-0011-R2A-SM-3NB1W GTEx Tissue Sample Gene Expression Profiles 1.0 0.869836 SUZ12-18974828-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null mRNA_SOX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null GTEX-SNOS-1126-SM-4DM67 GTEx Tissue Sample Gene Expression Profiles 1.0 1.6728 GTEX-WWYW-0011-R5A-SM-3NB3E GTEx Tissue Sample Gene Expression Profiles 1.0 0.88592 A704 CCLE Cell Line Gene CNV Profiles -1.0 -1.84519 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3346-01A-01R-1766-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PYGL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48182 CAMA1 DepMap CRISPR Gene Dependency 1.0 2.50227 cation transport GO Biological Process Annotations 2015 1.0 null PYGO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15984 GTEX-RU72-0126-SM-2TF6Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.86671 PLXNA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7706 Lung squamous cell carcinoma_LUSC_TCGA-92-7341-01A-31R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary motor cortex (area M1, area 4)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.885624 TE6 CCLE Cell Line Gene CNV Profiles 1.0 1.99236 PHLDA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23461 POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_H1-hESC_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFG8-1926-SM-4LVM1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.73144 CHCHD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20336 TYMS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68373 embryonic stem no feeder BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.05489 TK-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.856554 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4891-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WDR75 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22282 GZF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.07103 organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE198165,GSE198166_5_v_10_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4621-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Huntington disease KEGG Pathways 2026 1.0 null FOXP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.26343 substrate-specific transporter activity GO Molecular Function Annotations 2015 1.0 null YY1 MotifMap Predicted Transcription Factor Targets 1.0 null TMED4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55973 Small intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 KLHL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33318 GTEX-X5EB-2026-SM-4E3KA GTEx Tissue Sample Gene Expression Profiles 1.0 1.79352 PTPRG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45267 hsa-miR-132-3p MiRTarBase microRNA Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-ZG-A8QX-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAP2K1_knockdown_134_GSE31534 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.55298 SCC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13213 TUG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89323 hippocampus (hippocampal formation)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.831773 JHOM1 CCLE Cell Line Gene CNV Profiles 1.0 1.34591 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 496100554_FWM_no dementia_no TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.50935 EVA1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85231 H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KD DepMap CRISPR Gene Dependency 1.0 2.31874 SNU840 DepMap CRISPR Gene Dependency 1.0 3.78134 IRF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41346 NOS1 DepMap CRISPR Gene Dependency 1.0 3.36756 ZBTB18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07276 Spinal cord lipoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.893 PMC10721014-pone.0295542.s010.xlsx-Table_S9-Table_S9_Spearman_s_correlation_between_the_expression_levels_of_ESRRA_and_OXPHOS_subunits_genes_ESRRA Rummagene Transcription Factor Associations 2026 1.0 null CLDN10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25381 SUZ12 ChEA Transcription Factor Targets 1.0 null RNF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37225 Oogenesis phase fetal germ cell_Fetal gonad_Human CellMarker Gene-Cell Type Associations 1.0 null ARHGAP27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58979 lateral hemisphere of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08686 CTCF_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-IK-7675-01A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RNA Polymerase II Transcription Reactome Pathways 2024 1.0 null RASA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47658 Urinary tract TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 LU-139 COSMIC Cell Line Gene Mutation Profiles 1.0 null lateral nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.976223 HCC4006 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.27147 VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.56352 GTEX-U4B1-1526-SM-4DXSL GTEx Tissue Sample Gene Expression Profiles 1.0 1.60622 NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23912 TNFAIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31252 intracellular membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null MGA::EVX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.2183 ZNF662 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54819 SLC37A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37905 SLC6A15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44948 CXXC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17286 GTEX-TSE9-2926-SM-3DB77 GTEx Tissue Sample Gene Expression Profiles 1.0 0.925916 ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.13871 ASRGL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01882 Brain Lower Grade Glioma_LGG_TCGA-WY-A85A-01A-21R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null ZNF709 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37849 HCC364 CCLE Cell Line Gene Expression Profiles -1.0 -1.50179 SIRT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1998 GTEX-RVPV-0011-R11A-SM-2TF6F GTEx Tissue Sample Gene Expression Profiles 1.0 1.07404 embryoday7.5 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.898273 LN443 CCLE Cell Line Gene CNV Profiles 1.0 1.38414 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE201309_5_v_3_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null SUCLG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3652 GTEX-WL46-3026-SM-3LK7Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.889438 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q9-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH2141 CCLE Cell Line Gene CNV Profiles 1.0 2.04893 CTNND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73377 SG in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.888957 layer II of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.89099 TMED3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27661 NCIH1693 CCLE Cell Line Gene Expression Profiles 1.0 1.87959 THRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.033 PPP1R12A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.69088 CHAMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44451 outer CP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.845929 GTEX-TMMY-1326-SM-4DXU9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.85298 POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular organelle GO Cellular Component Annotations 2015 1.0 null SEPTIN8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68569 REH CCLE Cell Line Gene Expression Profiles 1.0 2.25277 MED16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89232 H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST-19997604-NEURONS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-2A-A8VX-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pontine nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.904069 L2HGDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43993 inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.00923 cytochrome-c oxidase activity GO Molecular Function Annotations 2015 1.0 null CA3 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.87022 GTEX-XMK1-2026-SM-4B65K GTEx Tissue Sample Gene Expression Profiles 1.0 1.76722 MOV10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.80999 cellular_component GO Cellular Component Annotations 2015 1.0 null SLC25A30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03089 CTCF_GM12871_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Viscus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 KNSTRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.87021 organelle LOCATE Curated Protein Localization Annotations 1.0 null DMS 79 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.67739 PEF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.43654 SUM149PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.546523 FST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67254 ARID4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75743 MFAP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01212 RPE1SS51 DepMap CRISPR Gene Dependency 1.0 3.26209 CCNB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93669 GTEX-V955-2426-SM-3GAEF GTEx Tissue Sample Gene Expression Profiles 1.0 0.973622 basomedial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.953443 ARL6IP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53387 APCDD1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0901 IRX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.09264 SMPDL3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8931 GSE241701_2_v_3_daxx_mouse RummaGEO Gene Perturbation Signatures 1.0 null SIM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56181 PRDM9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 165.106 ZKSCAN5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.6318 LOU-NH91 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.79048 molecular layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07287 TP63_01_197 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 4.08746 PGD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98568 MEIOC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52313 cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 PFEIFFER CCLE Cell Line Gene Expression Profiles 1.0 2.40871 SDF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42023 BICR 31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.836106 H3K9me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FOXD4L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47183 ZCCHC18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21933 subcuneiform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.876487 BAZ2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16259 PMC11461876-42003_2024_6975_MOESM3_ESM.xlsx-Supplementary_Data_1-Supplementary_Data_1_Differentially_Expressed_Genes_HSE_THP1_Vs_THP1_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YK-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE148200_0_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XAJ8-1326-SM-47JYT GTEx Tissue Sample Gene Expression Profiles 1.0 1.88443 PDCD6IP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30557 MELJUSO CCLE Cell Line Gene CNV Profiles -1.0 -1.91574 EMC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62872 NCAN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70518 GJD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94398 GTEX-R55F-0011-R6A-SM-2TF4L GTEx Tissue Sample Gene Expression Profiles 1.0 1.30988 WIDR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.961626 RXRA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60832 PLS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8463 mRNA_DLX3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Homodimeric serine palmitoyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.92 GRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95262 D2HGDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40748 ls1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.971 hsa-miR-3915 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8013-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JPH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26684 ZR-75-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.896926 DNAAF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68526 SNU-475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.888628 A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.919051 cell part GO Cellular Component Annotations 2015 1.0 null superior rostral gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.906839 MEC1 DepMap CRISPR Gene Dependency 1.0 4.14252 Prostate adenocarcinoma_PRAD_TCGA-G9-6329-01A-13R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LRIG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81322 SHMAC4 DepMap CRISPR Gene Dependency 1.0 3.3972 HRH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39843 KYSE-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.53692 DPH6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59607 hsa-miR-454 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 striatum_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.57649 PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5F-Up_H3K27me3_DPY30_KD-Unnamed_12_AR Rummagene Transcription Factor Associations 2026 1.0 null NCI-H28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13831 PIP4P1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7264 Prostate adenocarcinoma_PRAD_TCGA-H9-A6BY-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAD21_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-O5YT-2126-SM-3MJGD GTEx Tissue Sample Gene Expression Profiles 1.0 1.58799 Oxidative phosphorylation KEGG Pathways 2026 1.0 null layer IIIb of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.5285 HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.919051 DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.8073 ZNF524 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.08161 hydrogen transport GO Biological Process Annotations 2015 1.0 null superior olivary complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.856805 SAE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08863 GTEX-QDT8-0426-SM-32PKZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.841038 ABHD17A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41096 GTEX-NPJ8-0011-R3a-SM-2HMIW GTEx Tissue Sample Gene Expression Profiles 1.0 1.07487 GSE88819_6_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.21528 JUND_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null mitochondrial membrane GO Cellular Component Annotations 2025 1.0 null ZNF766 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.8018 PLA2G15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.03719 Brain Lower Grade Glioma_LGG_TCGA-P5-A733-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-N87 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.27859 BFTC909 CCLE Cell Line Gene Expression Profiles -1.0 -1.50263 SNX11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76945 HCC1428 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.45689 IRF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.5833 RPS8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41909 CA4 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.20495 striatum_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.05243 Psoas major TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.718 ERAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14922 TE-10 COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 POU2AF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.11033 CTCF_GM12869_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.27859 TUSC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9587 ARID1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92579 DES CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26508 HSPA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66477 CTCF_A549_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE200099_2_v_0_honokiol_human RummaGEO Drug Perturbation Signatures 1.0 null BICR16 CCLE Cell Line Gene Expression Profiles 1.0 1.6898 RBFOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.79902 oculomotor nuclear complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.44342 RO60 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66146 HOXC13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97333 tail of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.44253 biological_process GO Biological Process Annotations 2015 1.0 null NCIH1355 CCLE Cell Line Gene Expression Profiles 1.0 1.40819 DBF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11854 GTEX-Q2AI-1226-SM-48U14 GTEx Tissue Sample Gene Expression Profiles 1.0 1.89518 cytoplasmic part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 interstitial nucleus of Cajal, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.906929 IRS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51702 BT549 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.02601 NAP1L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04074 ZFP14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.07033 RAD21_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30763 Prostate adenocarcinoma_PRAD_TCGA-XQ-A8TA-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WVLH-2926-SM-3MJG5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20821 ZNF676 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38427 GTEX-REY6-0126-SM-48FDT GTEx Tissue Sample Gene Expression Profiles 1.0 2.31131 temporal pole, right, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.37462 H1-8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71125 transporter activity GO Molecular Function Annotations 2015 1.0 null TAF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80961 ion transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null GTEX-XPVG-2226-SM-4B65U GTEx Tissue Sample Gene Expression Profiles 1.0 1.64181 PCSK7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.31487 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYC ENCODE Transcription Factor Targets 1.0 null STOX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60371 RTKN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04392 membrane GO Cellular Component Annotations 2015 1.0 null hippocampus (hippocampal formation)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.22886 HCC2935 CCLE Cell Line Gene CNV Profiles 1.0 1.44785 GABARAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61522 SLC29A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52274 H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF671 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42833 Lung squamous cell carcinoma_LUSC_TCGA-94-A5I6-01A-21R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-NPJ7-0011-R11A-SM-2I3E8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.824262 C1QTNF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06698 C-33 A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.63762 ZBTB32 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.4643 FAM120B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85166 NANS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84451 spleen BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.06843 ZNF175 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.0271 SMAD2-18955504-HACAT-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ZIC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77284 EFM-192B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.828632 PMC11033585-BLOOD_BLD-2023-021752-mmc2.xlsx-S10_DGEA_IKZF1-Supplemental_Table_10_Differentially_expressed_genes_between_IKZF1_and_all_other_subcluster_IKZF1 Rummagene Transcription Factor Associations 2026 1.0 null ZNF419 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47005 H2BC26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62887 ZNF479 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9709 CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellar cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.16505 inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.13408 H3K9me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null posterior orbital gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.98205 CACNA2D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36247 SLC35E2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99882 HCC2218 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.731704 oxidative phosphorylation KEGG Pathways 1.0 null pancreas BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.24395 MAFA MotifMap Predicted Transcription Factor Targets 1.0 null IGFBPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43765 GTEX-OHPM-2126-SM-3LK75 GTEx Tissue Sample Gene Expression Profiles 1.0 2.12253 Metallochaperone complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.234 ERI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.61342 arcuate nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.12157 Sarcoma_SARC_TCGA-K1-A3PN-01A-11R-A22K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC4006 CCLE Cell Line Gene CNV Profiles 1.0 1.59187 hsa-miR-3666 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 IRF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.17794 testis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 MLXIPL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70456 C20orf96 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51809 YY1AP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11286 inner SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.846992 MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.828632 Brain Lower Grade Glioma_LGG_TCGA-TM-A84I-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SOX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13963 CHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.43074 ERI3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15483 H3K9me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null decitabine_homo sapiens_gpl570_gse30985 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-NL4W-0011-R11A-SM-2I3DW GTEx Tissue Sample Gene Expression Profiles 1.0 1.13973 ARL5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.10822 PSAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25865 RUSC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80749 CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WL46-2826-SM-3LK81 GTEx Tissue Sample Gene Expression Profiles 1.0 0.857138 TOR3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45469 MED13L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47573 polysensory temporal cortex (area 22p) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.24755 FOXP1-21924763-HESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null TTC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89672 ST6GAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38403 Prion disease KEGG Pathways 2026 1.0 null MPST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.16066 CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null Tethered spinal cord syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.753 COV504 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05795 A3/KAW Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13213 RBM10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94831 SMZ1 DepMap CRISPR Gene Dependency 1.0 2.73812 OLFML3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4405 cerebellar cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.890562 CREM JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.1608 CLASP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62068 single-organism localization GO Biological Process Annotations 2015 1.0 null GTEX-OOBJ-2126-SM-3NB1N GTEx Tissue Sample Gene Expression Profiles 1.0 1.65294 OGDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3092 oxidoreductase activity, acting on a heme group of donors GO Molecular Function Annotations 2015 1.0 null outer SZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.88295 hsa-miR-106b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 SJSA1 CCLE Cell Line Gene Expression Profiles -1.0 -1.75006 PGBD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28769 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5678-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Diabetic cardiomyopathy KEGG Pathways 2026 1.0 null PTDSS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85252 SF268 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.96522 PMC8554124-DataSheet2.XLSX-4-RORA_RORA Rummagene Transcription Factor Associations 2026 1.0 null membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.046518 GTEX-X585-0011-R11B-SM-46MUZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.38857 H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null primary motor cortex (area M1, area 4)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.30939 SLC25A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29259 organelle GO Cellular Component Annotations 2015 1.0 null CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00071 H3K9me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-HL-60-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_HL-60_LYL1 Rummagene Transcription Factor Associations 2026 1.0 null PBX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.9069 SLC38A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58192 CTCF_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.890562 NU-DUL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.6031 cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 3.4231 GTEX-TKQ2-1526-SM-4DXUN GTEx Tissue Sample Gene Expression Profiles 1.0 1.81266 dorsolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.34201 H3-4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73527 STARD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.11811 FAF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27296 RNF169 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44182 Complex IV assembly Reactome Pathways 2024 1.0 null IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1167 CTCF_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null organelle membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 TUBB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7536 Prostate adenocarcinoma_PRAD_TCGA-EJ-7321-01A-31R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Mitochondrial respiratory chain complex IV COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.712 CTCF_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mRNA_MYC_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null hydrogen ion transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null EMC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58366 MTHFS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15163 molecular_function GO Molecular Function Annotations 2015 1.0 null Huntington's Disease_Lymphocyte_GSE8762 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.53214 9505BIK DepMap CRISPR Gene Dependency 1.0 2.29419 t63-testes_consensus MoTrPAC Rat Endurance Exercise Training 1.0 1.44521 HEATR5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.96706 RELL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32824 L3MBTL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7246 MAFK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05193 cerebellar cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.848637 Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A66S-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-O2-A52S-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A6E8-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UQCR10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66002 anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.35231 GSE146982_7_v_5_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null erg_19359602_huvec_lof_human_gpl570_gds3557 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.952339 H3K4me1_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null THAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30878 FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null HCC1359 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.964004 GSE88819_3_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4W0-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH522 CCLE Cell Line Gene CNV Profiles 1.0 1.52671 GTEX-WH7G-1926-SM-4LVMM GTEx Tissue Sample Gene Expression Profiles 1.0 2.10293 dorsolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.97378 RAD21_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JHH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.875651 ventral posterior lateral nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09518 ZNF471 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49761 RAB7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52072 CAAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.32176 Pathways of neurodegeneration - multiple diseases KEGG Pathways 2026 1.0 null AKAP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98222 CTCF_GM12865_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null oculomotor nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01832 CTDSPL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.11292 18614019-TableS4c GeneSigDB Published Gene Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5107-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.052107 SP in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.53633 hsa-miR-301b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 INA6 DepMap CRISPR Gene Dependency 1.0 3.27865 CLDN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66389 monovalent inorganic cation transport GO Biological Process Annotations 2015 1.0 null Respiratory electron transport Reactome Pathways 2024 1.0 null intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PW2O-0426-SM-48TCC GTEx Tissue Sample Gene Expression Profiles 1.0 0.892983 EXO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75232 ZNF460 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81345 nih 3T3 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.26331 GSE176008_4_v_1_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null MSX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.9173 NFATC3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.0026 CtIP_DEPLETION_GDS2189_122_human_MCF10A mammary epithelial cells (MECs) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null hsa-miR-519a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 SORL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5072 GSE152441,GSE152442_0_v_3_folic acid_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null FAM219A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17767 GTEX-S4Q7-1226-SM-4AD5I GTEx Tissue Sample Gene Expression Profiles 1.0 1.76521 Alimentary canal TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 STX17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.20375 MDAMB231 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.719726 GW body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.652 SIN3A-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null cuneiform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.51593 SMAD3-18955504-HACAT-HUMAN ChEA Transcription Factor Targets 2022 1.0 null C5orf24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.33459 G402 DepMap CRISPR Gene Dependency 1.0 2.45669 ATP5MJ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.289 lateral dorsal nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.92263 HCC2935 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34328 HCC1319 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.35503 GTEX-PLZ5-1526-SM-3P5ZX GTEx Tissue Sample Gene Expression Profiles 1.0 1.60942 Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.821 retina BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.0014 RAB11FIP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01014 OR2A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.12186 HGS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79426 BACE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45814 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039167 HDAC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08096 TRABD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69308 TFAP2A-17053090-MCF7-human ChEA Transcription Factor Binding Site Profiles 1.0 null TCF12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.1249 SPIC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.3268 NLGN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65895 NR2F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6048 Transcriptional Regulation by TP53 Reactome Pathways 2024 1.0 null TNS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74201 SCC4 CCLE Cell Line Gene CNV Profiles 1.0 1.89025 CTCF_MCF-7_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null HUO9 DepMap CRISPR Gene Dependency 1.0 2.6701 TMEM106B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7075 mitochondrion LOCATE Curated Protein Localization Annotations 1.0 null Gastroesophageal reflux disease GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.909691 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YH-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KLHL7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54109 CTCF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GTEX-Q2AH-1526-SM-48TZG GTEx Tissue Sample Gene Expression Profiles 1.0 1.98563 PAX6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.6977 Xanthine dehydrogenase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.096 MZ in dorsomedial parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06153 CGTHW1 CCLE Cell Line Gene Expression Profiles 1.0 1.52786 GSE131377_1_v_3_spocd1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.03604 NALM19 CCLE Cell Line Gene Expression Profiles 1.0 1.79971 ATF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30312 GSE158285_0_v_1_ddx5_mouse RummaGEO Gene Perturbation Signatures -1.0 null DR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66949 HCV_8week-No IFN-a_None_GSE37715 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.07192 RNF144A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61713 KPL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.27321 PMC6879454-Data_Sheet_1.xlsx-AA_in_vitro-Unnamed_4_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null mRNA_NANOG_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-LB-A7SX-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UBE2S CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00151 GTEX-NPJ8-2626-SM-2D7W2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.37997 OVMANA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.47559 GTEX-XMD1-0011-R11A-SM-4AT5J GTEx Tissue Sample Gene Expression Profiles 1.0 1.43795 AK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.1084 COLO 699 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.919051 ion transmembrane transport GO Biological Process Annotations 2015 1.0 null BICR16 CCLE Cell Line Gene CNV Profiles 1.0 2.16699 cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041453 hsa-miR-19b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 MICAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76119 HHIPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85888 Mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.387 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FU-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H2126 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.38796 FAAP100 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82428 DMS79 CCLE Cell Line Gene CNV Profiles 1.0 1.64114 GTEX-R55E-0011-R7A-SM-2TC5Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.00631 DAPK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43076 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4799-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.25904 PGLYRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24902 ETV5::FOXO1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.3565 trochlear nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.31186 primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01004 pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XQ8I-0726-SM-4BOPU GTEx Tissue Sample Gene Expression Profiles 1.0 0.865771 GTEX-R55E-0011-R5A-SM-2TC5N GTEx Tissue Sample Gene Expression Profiles 1.0 1.15778 ZBED1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.0758 RFX7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.941 EVSAT CCLE Cell Line Gene Expression Profiles -1.0 -1.89411 GTEX-NPJ8-1426-SM-3MJHR GTEx Tissue Sample Gene Expression Profiles 1.0 1.41622 UNCX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.6262 KP4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.908915 IGFLR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30726 GTEX-XGQ4-2026-SM-4AT6G GTEx Tissue Sample Gene Expression Profiles 1.0 1.93495 GGCX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84393 RFNG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37717 Pancreatic adenocarcinoma_PAAD_TCGA-HV-A5A6-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PCM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9041 MDAMB453 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 2.01957 GTEX-WWYW-0526-SM-3NB2W GTEx Tissue Sample Gene Expression Profiles 1.0 0.931441 CTCF_GM12874_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 RTN4IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88166 hsa-miR-4766-5p TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 ALDOC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56273 CTCF_MCF-7_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ7-2826-SM-2I3FU GTEx Tissue Sample Gene Expression Profiles 1.0 1.08115 GSE162688_1_v_2_pink1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SMAD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.8195 CI1 CCLE Cell Line Gene Expression Profiles 1.0 1.43014 Brain Lower Grade Glioma_LGG_TCGA-VM-A8CF-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CDC25B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.66565 ZHX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70207 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8005-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU1079 CCLE Cell Line Gene CNV Profiles 1.0 1.41108 POLI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35047 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4619-11A-01R-1758-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral posterior nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03327 RAD21 ENCODE Transcription Factor Targets 1.0 null TBC1D7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80365 Sarcoma_SARC_TCGA-IF-A4AJ-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH727 DepMap CRISPR Gene Dependency 1.0 2.55816 FEZ2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73834 posteroventral (inferior) parietal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.92922 NCI-H2461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00044 pontine reticular formation, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.888301 GTEX-XQ8I-2326-SM-4BOQC GTEx Tissue Sample Gene Expression Profiles 1.0 1.13058 KP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03339 LN382 DepMap CRISPR Gene Dependency 1.0 3.08669 MAZ ENCODE Transcription Factor Targets 1.0 null PGBD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05637 FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.6019 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null primary auditory cortex (core)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.976577 GTEX-UJMC-0526-SM-3GAE3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.853065 dorsal motor nucleus of the vagus (vagal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.68792 Cellular responses to stress Reactome Pathways 2024 1.0 null dentate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.00084 LOUCY CCLE Cell Line Gene Expression Profiles 1.0 2.12813 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_3_FIGLA Rummagene Transcription Factor Associations 2026 1.0 null GSE144115_2_v_3_stag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.1478 Chemical carcinogenesis - reactive oxygen species KEGG Pathways 2026 1.0 null STC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52319 VMRCRCZ CCLE Cell Line Gene CNV Profiles -1.0 -1.33838 Sarcoma_SARC_TCGA-DX-A7EM-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FKBP1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02496 transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null FOXRED2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00843 GSE134986_2_v_8_oma1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WWYW-0011-R6A-SM-3NB3G GTEx Tissue Sample Gene Expression Profiles 1.0 0.951872 MFGE8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50723 496100458_FWM_no dementia_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.35384 Excretory gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GARRE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81802 19139136-TableS3 GeneSigDB Published Gene Signatures 1.0 null SAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5956 rostral subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.922219 CALML6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.33064 salivary gland GTEx Tissue Gene Expression Profiles -1.0 -1.38545 H3K4me1_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null striatum_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.834063 single-organism process GO Biological Process Annotations 2015 1.0 null GTEX-OIZG-1126-SM-2HMIU GTEx Tissue Sample Gene Expression Profiles 1.0 0.899047 EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05001 SEPTIN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.9302 TMEM265 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58542