association	dataset	threshold value	standardized value
GSE206226_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K26694226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20306
GSE154577_7_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K84054400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17143
496100359_PCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.9507
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.835
A549_Gandotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0279742
Meiotic prophase fetal germ cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
CRCGN015_MCF10A.TP53.M_24H:M18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5037
A549_Belinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0104408
GSE105170,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K93483334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82407
GSE182854_2_v_0_sirt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K37684893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.36515
CRCGN010_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.8926
BRD-K79523827	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39483
GSE225762_1_v_0_pcmt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Hyperopia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.342
A549_PFI-1_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0258459
CRCGN011_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.8712
GSE144838_1_v_8_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29535
GSE229468,GSE229471_0_v_3_znf587_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EBNA1BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22705
Brain stem	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE128730_0_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26435
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-Non-spreading_targets_gene_names_2497_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120612_7_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.84046
GSE217526_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100476_TCx_no dementia_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.40469
A549_TMP195_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.03519
BRD-K80073743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06941
PMC11445528-44318_2024_208_MOESM5_ESM.xlsx-AA-geneSymbol_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Zileuton_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.037086
A549_Daphnetin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01249
BRD-K27612721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1154
Penfluridol_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.018314
GSE203485_1_v_0_sunitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Communication disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.351
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_MLN8054_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173599
GSE227891_5_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6655
GSE125014_1_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135030_3_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0233986
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.369347
GSE151782_2_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.649
GSE215351,GSE215794_2_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_BMS-265246_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224777
SLC25A37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46269
A549_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187625
GSE149075_6_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Orofaciodigital syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.958
A549_S3I-201_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0302099
ABCF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00759
BRD-K26091803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1726
CDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9849
GSE174498,GSE174500_5_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5848610-supp_gr.228809.117_Supplemental_Table_S4.xlsx-Table_S4E-Supplemental_Table_S4E_List_of_differentially_expressed_genes_upon_siZFX_with_promoters_bound_by_ZFX_in_MCF-7_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K56976888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10145
A549_Barasertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191466
CRCGN009_HEPG2_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0894
ARPP19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29594
GSE131377_4_v_3_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE231648_0_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PHOX2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.1472
A549_EED226_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136338
A549_FLLL32_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0391229
BRD-A91461229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02669
BRD-K72484719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00877
BRD-K03479638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06304
A549_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0257258
A549_Roscovitine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187461
A549_Pracinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149905
A549_Epothilone A_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160926
A549_Hesperadin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013601
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE165548_2_v_4_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K94301203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62855
BRD-K99873441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13448
BRD-K35780971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31766
Retinal degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.726
TOMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55319
BRD-K18211442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00358
Nephrotic syndrome type 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.976
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Ofloxacin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0283578
GSE157555,GSE157556_4_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal renal tubule epithelial cell primary cilium morphology	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K05137000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39076
Kinesin II complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.659
A549_XAV-939_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0290244
WDR77	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8158
PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
Primary ciliary dyskinesia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.509
GSE236437_2_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.283068
Homoharringtonine_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00642849
GSE224131_2_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.88625
NUDT14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33686
A549_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188097
Keratocyst	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.696
PMC11161988-12906_2024_4523_MOESM3_ESM.pdf-72-SIX6_SIX6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193258,GSE193259_5_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169152_5_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Andarine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0228353
ATP1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57919
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K71262871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67325
GSE228894_0_v_1_rnmt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12619835-41467_2025_66007_MOESM12_ESM.xlsx-KLF5_activated_H3K27ac_T3M4-Nearest_Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K74540252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38556
BRD-K78837609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53498
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5187
GSE201217_4_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K07486034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07811
GSE99687_3_v_1_smad5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Rutin (trihydrate)_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0182197
GSE210476_9_v_7_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K82683018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76303
GSE216043_3_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Chromosomal duplication syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
BRD-K00191683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52843
A549_Ki8751_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0230997
Primary coenzyme Q10 deficiency 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.144
GSE205163,GSE205164_9_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.406521
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table2_ChinaMAP_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K74789550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32529
496100341_TCx_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.12897
GSE140997_2_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF644	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28864
FE-64-KC49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.350691
A549_Tozasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167614
BC-13-OQ01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225801
Brachydactyly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.43
GSE133764_2_v_0_chd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_PCI-34051_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0265103
FOXA1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
Y-shaped link	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.488
TSPAN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54834
BRD-K50600207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41864
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-All_targets_genes_names_2597_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE157555,GSE157556_0_v_1_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Genes related to primary cilium development based on CRISPR 	WikiPathways Pathways 2024	1.0	null
BRD-K36923996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.47581
GSE186647,GSE217288_2_v_4_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223008_6_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Tanespimycin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119699
BRD-K32259584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17502
MCF7_Cimetidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155506
Intraciliary transport particle A	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.062
MCF7_Lenalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160579
RNF138	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90335
TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE246053_1_v_2_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.827
GSE92364_0_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147876,GSE147877_2_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Abductor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.805
A549_MK-5108_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223359
BRD-K19702946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04925
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K75252192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67393
BRD-K46119789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03847
PMC4580625-pone.0138726.s006.xlsx-Immune_molecular_modules-NFATC3_mod_NFATC3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE126345_0_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE225141,GSE225143_2_v_3_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_TG101209_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162292
Malaria	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.604576
GSE226316_6_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173849
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278534
MCF7_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148695
CRCGN017_MCF10A.WT.HP_24H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48035
Caroli syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.258
STK24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08452
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
non-motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.662
CRCGN016_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19384
A549_Enzastaurin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0234522
Bexarotene	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.74
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.629
KAT6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06271
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271484
GSE191015_0_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Height	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.3699
CRCGN015_MCF10A.TP53.M_24H:O22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08625
CRCGN008_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.24225
BRD-K01762107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.77241
BRD-K96209756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01522
A549_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0294816
GSE88819_5_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6087
MCF7_Navitoclax_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201726
BRD-K13071687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03501
BRD-K69775722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50528
MCF7_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131117
BRD-K27049948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02632
A549_Mocetinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199169
BRD-K80381603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56487
Frontometaphyseal dysplasia 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.266
GSE203158_12_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K57732605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96082
Microtubule organizing center	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.825
Leukopenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.238
A549_BMS-265246_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0297891
GSE102505_1_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ATP6V1E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07875
GSE193258,GSE193259_9_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Familial nephrotic syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
Waardenburg syndrome type 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
PMC5263239-mmc2.xls-MV4_11_-_MLL-AF4-Non-spreading_targets_gene_names_1985_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Myelocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.522
Pontocerebellar hypoplasia type 1A	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.256
A549_TMP195_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0463508
GSE60837_0_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Elimusertib hydrochloride_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0173026
PMC11073972-41375_2024_2232_MOESM2_ESM.xlsx-REL-14_CD7_CD1a_DEG-DEG_L2FC_1_0_FDR_0_05_REL	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K02392990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03646
GSE210101,GSE210114_11_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
PFDN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09212
GSE159678_6_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.9217
Usher syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.026
CRCGN008_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.36565
MCF7_BMS-536924_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131588
abnormal primary cilium morphology	MGI Mouse Phenotype Associations 2023	1.0	null
GSE209898,GSE209899_0_v_1_flcn_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6713698-109_2019_1809_MOESM2_ESM.xlsx-AR-PCOS-Gene_List_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A00881124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48824
PMC4856960-supp_gkv1471_nar-01762-z-2015-File012.xlsx-GO_common_7H-HIF1_chip-Common_elements_in_chip7h_and_chip_hif1_2530_official_gene_symbols_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K98427581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34579
right aortic arch	MGI Mouse Phenotype Associations 2023	1.0	null
DND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41389
GSE211128_2_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE87412,GSE92423_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Alisertib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184824
GSE166783_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.466873
BRD-K98061543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74707
A549_Daphnetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0322846
Autosomal dominant polycystic kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.225
HY-50713	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
BMS 303141	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.23
GSE203158_5_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0252483
A549_Daphnetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018884
GSE114883_1_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE144838_1_v_5_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K79299080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28288
KIT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22979
ML264_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0126806
UPF 648	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.71
Bardet-Biedl syndrome 14	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
GSE144115_1_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Patupilone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199631
GSE202603_1_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169713,GSE169715_1_v_2_tert_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE128730_3_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K48780709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10156
GSE229973_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Thiotepa_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0267629
BRD-K86995890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79106
PMC9643473-Table1.xls-MAF_0_005-HGVS_gene_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE86507,GSE86509_7_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12164972-FSB2-39-e70689-s001.pdf-9-NFATC3_NFATC3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE203158_0_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Clevudine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0265015
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.353
GSE154577_7_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182836
Strabismus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.459
Berberine (chloride hydrate)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0233707
BRD-K80233876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09203
GSE182185_0_v_1_pstk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NPHP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.208
HOXB13-26457646-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE213588_9_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE200320_3_v_2_mfge8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE219274,GSE219276_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K02078984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58001
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.086
Lymphatic system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.353
A549_Linifanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0305669
Metatarsal bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.546
SLC10A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42918
SYO1	DepMap CRISPR Gene Dependency	1.0	5.15722
A549_SRT2104_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186212
embryonic growth retardation	MGI Mouse Phenotype Associations 2023	1.0	null
A549_PD173074_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144806
RNF149	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62264
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table6_gnomAD_EUR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K94993773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6445
FAM204A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40612
GSE163240_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE225218_9_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K83270677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0149
Pinometostat	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.97
CRCGN014_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07175
A549_CUDC-101_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0277573
EX229_NCI-H23	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0187085
GSE151829,GSE151831_3_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Colon - Transverse	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.01993
Heart septal defect	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.071
ABL	Kinase Library Tyrosine Kinome Atlas	1.0	95.58
A549_S3I-201_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216392
GSE168587,GSE168752_3_v_1_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Barasertib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0303775
NEPRO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1491
MCF7_Epothilone A_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192718
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SKNEP1	DepMap CRISPR Gene Dependency	1.0	2.00781
A549_Iniparib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0242525
PMC10714175-mmc2.xlsx-KD_Gene_list-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.4598
End stage renal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.272
A549_UNC1999_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.016807
EPHA6	Kinase Library Tyrosine Kinome Atlas	1.0	96.52
CRCGN014_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.77364
BRD-K46376359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51128
BRD-K02927989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74163
A549_Maraviroc_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171151
Kinocilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.643
Patau syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.233
PMC10746608-427_2023_709_MOESM5_ESM.xlsx-SOX2_partners-SOX2_known_protein_partners_according_to_BioGrid_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K27754030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25925
GSE229973_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SRC	Kinase Library Tyrosine Kinome Atlas	1.0	95.58
GSE235066_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cilium	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
A549_IOX2_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177252
GSE154577_6_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0338023
A549_Abexinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177727
A549_Veliparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196867
BRD-K06020071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03575
GSE95302_2_v_3_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Dacinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131845
GSE235066_4_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE173578_1_v_0_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Hesperadin_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202988
MCF7_Linifanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182975
GSE152441,GSE152442_1_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3938
PMC11601903-jciinsight-9-175998-s107.pdf-4-WT1_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K56231599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28002
Mouth	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.086
MCF7_Nintedanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144333
BRD-K78596805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12224
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.436
ICC2	DepMap CRISPR Gene Dependency	1.0	11.5428
Caroli disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.259
GSE175787_4_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_8_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Meat-related diet	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.730103
MCF7_CYC116_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0104765
BRD-K99412981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04573
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_body_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Polygenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.17
GSE173997_3_v_0_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205163,GSE205164_5_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.66
GSE210383_0_v_1_trim71_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K43341506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43431
BRD-K61494613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03478
NAA50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28522
A549_SRT3025 HCl_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154973
CRCGN012_HEPG2_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7044
A549_TMP195_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219806
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4102
GSE152441,GSE152442_0_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
A549_Navitoclax_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0314703
AC-7954	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.54
GSE148657_2_v_1_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE220520_3_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE88819_5_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0639
BRD-K70116387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01089
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Osteochondrodysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.633
GSE133516_5_v_1_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.396657
Autosomal dominant intellectual developmental disorder 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.936
CRCGN017_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05532
PMC7064337-elife-51373-supp1.xlsx-MTF2_targets_shCTR-List_of_2011_genes_marked_by_MTF2_ChIPseq_in_control_conditions_shCTR_MTF2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE140651,GSE140653_5_v_7_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Iniparib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137186
UBXN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60543
BRD-K81932943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01061
plasma membrane bounded cell projection assembly	GO Biological Process Annotations 2025	1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K25447152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18332
AC-28-RT00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21858
A549_Hesperadin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178316
A549_Iniparib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0243454
TRMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77988
A549_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0258447
Cervical spine	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.847
Hedgehog signaling complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.341
GSE239844_6_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K59437706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24603
BRD-K69248736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38381
Blepharophimosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.178
CCK81	DepMap CRISPR Gene Dependency	1.0	13.7748
GSE154577_2_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186647,GSE217288_1_v_4_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K31834149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81599
A549_2-Methoxyestradiol_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0105946
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.599652
5762_NPAT_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.26178
496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.83415
GSE161825_1_v_0_tipranavir_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K71486304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1165
GSE104508_2_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AA92593	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.62
FE-64-KC49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207341
GSE114232_8_v_11_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8384902-mmc6.xlsx-DEG_3TF_KD_unique-GeneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Genetic disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7312
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.1503
ALG10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82563
ZBED2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24224
BRD-K29614616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34025
Agranulocytosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.343
GSE182680,GSE182683_10_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE206226_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cone dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.124
Floor plate	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.067
GSE165682_4_v_3_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1d-List_of_2302_of_genes_differentially_regulated_by_SOX2_FDR_0_1_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
A549_TAK-901_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0249658
MCF7_FLLL32_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132953
BRD-K04877446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63422
A549_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197509
BRD-K59523233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46114
GSE161846,GSE161849_1_v_5_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal nonmotile primary cilium morphology	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K68984041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.4605
thiamine-responsive megaloblastic anemia syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.214
BRD-K07278815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40156
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_SRT1720 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148858
kidney cyst	MGI Mouse Phenotype Associations 2023	1.0	null
PMC5474565-onc2016488x2.xlsx-Table_S4_MLL_Target_Genes-MV4-11_MLL-AF4_target_genes_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7927818-AAC.01755-20-s0002.xlsx-Supplemental_Table_1-Supplemental_Table_1_List_of_significantly_altered_genes_in_MDMs_differentiated_in_the_presence_of_PrEP_FTC_v_No_Drug_TDF_v_No_Drug_FTC_v_TDF_SRY	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178267_2_v_0_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE200352_1_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE192663_3_v_2_acly_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.353
GSE255680_2_v_0_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Refractive error	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.333
GSE231720,GSE231724_2_v_0_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_MK-0752_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156774
GSE165682_4_v_5_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ficolin-1-rich granule lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.619
GSE198165,GSE198166_0_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Capecitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131873
BRD-K78262424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27547
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
127399	DepMap CRISPR Gene Dependency	1.0	2.37574
GSE169205_0_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210101,GSE210114_1_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186633_1_v_0_chd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
cleft palate	MGI Mouse Phenotype Associations 2023	1.0	null
GSE101112_0_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Myotome	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.866
BRD-K90429860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47478
BRD-K08715918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06131
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Navitoclax_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0107466
A549_Mocetinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0235002
BRD-K78712486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72095
FES	Kinase Library Tyrosine Kinome Atlas	1.0	99.39
BRD-K64345025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.099
BRD-K91021522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24185
Ciliary transition zone	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
GSE110178_2_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6974
BRD-K27680690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0167
A549_SGI-1776 free base_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0105189
496100473_TCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.24852
A549_TGX-221_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204558
Brain - Frontal Cortex (BA9)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.06051
GSE193258,GSE193259_5_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SCH	DepMap CRISPR Gene Dependency	1.0	2.19555
CRCGN009_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.38411
BRD-K05154886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1961
Brain disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
A549_GSK-LSD1 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192526
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
micrognathia	MGI Mouse Phenotype Associations 2023	1.0	null
GSE158815_5_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133087_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176904
GSE135030_11_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145071
GSE158834_11_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K30310008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68319
A549_Baricitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0237417
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.33995
BRD-K27914478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42069
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.156
GSE189772,GSE189773_3_v_2_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K43306617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10936
PMC8851354-Table_6.xlsx-STAT3-bound_genes_GM12878-Supplementary_Table_6_STAT3-bound_unique_genes_in_GM12878_cells_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE140997_2_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE175787_5_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HNRNPF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01287
Visceral heterotaxy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.738
Simpson-Golabi-Behmel syndrome type 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.416
A549_Pracinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.012908
BCAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50679
MLXIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31047
MCF7_Luminespib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0250143
EOMES	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9848
GSE89018_12_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE144231_2_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KB-49-NF63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276971
A549_Fasudil_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153477
GSE154577_7_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.436
A549_Roxadustat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019604
HCC1954	DepMap CRISPR Gene Dependency	1.0	2.66882
MCF7_Fluorouracil_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148629
BRD-K37387086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.6519
A549_Quercetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194522
BRD-K99755021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68249
GSE166315_2_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211286_4_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_BMS-754807_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197022
GSE157960_2_v_3_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
abnormal eye morphology	IMPC Knockout Mouse Phenotypes	1.0	null
PMC12619835-41467_2025_66007_MOESM13_ESM.xlsx-Sheet1-T3M4_KLF5_activated_H3K27ac_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
9+0 motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.744
Immune system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.353
BC-01-JL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.32606
GSE158632_2_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EPB41L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05044
GSE100863,GSE100864_3_v_0_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K25933460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39286
GSE244072_10_v_9_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K77046858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26813
A549_TGX-221_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0318075
A549_Ramelteon_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.02367
MCF7_Entacapone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168509
SLC17A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54086
GSE239541_8_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K43889095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01434
A549_Sodium Phenylbutyrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0459304
Synostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.747
AC-28-RT00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300042
Otopalatodigital syndrome type 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.198
Ciliopathy	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
BRD-K07988588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18581
GSE200687,GSE200688_1_v_0_sox15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00823656
CRCGN011_HEPG2_24H:C03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00065
NR4A2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6603
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.254
PMC8656035-40001_2021_613_MOESM2_ESM.docx-11-ZNF827_ZNF827	Rummagene Transcription Factor Associations 2026	1.0	null
GSE246660_1_v_0_lmo3_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Fedratinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0226694
UMI-77	DeepCoverMOA Drug Mechanisms of Action	1.0	0.49
BRD-K47217000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19643
Body dysmorphic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.358
impaired wound healing	MGI Mouse Phenotype Associations 2023	1.0	null
TBX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7374
LS	DepMap CRISPR Gene Dependency	1.0	10.9294
BRD-K76691746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00115
BRD-K90956468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00177
MCF7_Thiotepa_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176455
BRD-K07667635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2104
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.981
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6022
A549_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175775
Meckel syndrome 13	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.897
496100570_HIP_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.05497
A549_Alendronate sodium trihydrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0268932
GSE158431_2_v_0_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K54814515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16696
BRD-K13206026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37628
GSE113221,GSE113968_6_v_1_prdm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K67689282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20937
GSE154577_2_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K63154470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00961
Hydrolethalus syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.766
A549_TG101209_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183922
KCNMB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.216
Palatine uvula	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.54
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.14555
CRCGN012_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40671
BRD-K67902591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66204
Laryngeal cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.954
BRD-K44684577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04323
MCF7_Fedratinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158961
CRCGN014_HEPG2_3H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.03385
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0312587
BRD-A17635048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07218
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_U87MG_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147056_4_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151782_2_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210662_3_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.884
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.90503
A549_SNS-314 Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182744
BRD-K79329532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33139
Acrocallosal syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.06
PMC9541747-AGE-53-680-s003.xlsx-TableS6-Table_S6_Genes_with_missense_mutations_in_Yaroslavl_cattle_MAF_0_1_and_FST_0_4_in_the_1000_Bull_Genomes_Run_9_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
MIDEAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15772
MCF7_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0237049
GSE201239_0_v_7_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Selinexor _NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00664919
SMIM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08629
A549_PHA-680632_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187443
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254216
(S)-(-)-Pindolol	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
BRD-K03599766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15207
GSE80098,GSE80366_0_v_5_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K66311249	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.3966
GSE152734,GSE152735_1_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Photoreceptor cell cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.024
PMC7401461-iovs-61-3-10_s001.xlsx-Sheet1-SRY_SRY	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Prednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158638
A549_ABT-737_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232361
ZHX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66123
KAT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16125
MCF7_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124061
Axonemal microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.867
GSE143994_2_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE156923_2_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_SNS-314 Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140162
GSE125014_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE141726,GSE141733_1_v_0_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Acifran	DeepCoverMOA Drug Mechanisms of Action	-1.0	-3.31
BRD-K66479240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16716
MAP4K3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44985
Ciliopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.115
BD-96-HO33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213538
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.214
BRD-K16843478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14025
BRD-K30318008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86607
CRCGN014_HEPG2_3H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.33692
PMC9424213-41467_2022_32537_MOESM6_ESM.xlsx-siHNRNPK_cyto-DEGs_for_hnRNPK_KD_cytoplasmic_RNA_of_HeLa_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K23782109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72356
496100366_TCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.38573
GSE147876,GSE147877_4_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Torcetrapib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-2.1
BRD-K81956993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18612
CRCGN015_MCF10A.WT.HP_24H:P15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09709
Proglumide_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0294718
Arachnoid mater	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.183
BRD-K74259627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60632
Dysostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.785
BRD-K21935128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01253
Hematopoietic system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.353
PMC10684515-41467_2023_43264_MOESM7_ESM.xlsx-HOXA9_ChIP-seq_peaks_in_SEM-Closest_Gene_HOXA9	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171845_4_v_3_ccne1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Nilotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152335
XRK3F2_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0122737
ATP6V0D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02617
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
PL4	DepMap CRISPR Gene Dependency	1.0	2.34732
A549_AZ 960_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143661
MCF7_Vandetanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121961
A549_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0297436
Pallister-Hall syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.855
GSE223008_4_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hindbrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE210101,GSE210114_0_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
plasma membrane bounded cell projection assembly	GO Biological Process Annotations 2023	1.0	null
Ptosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.71
A549_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175363
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.540065
abnormal heart morphology	MGI Mouse Phenotype Associations 2023	1.0	null
SRSF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43821
GSE120612_4_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BEN cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.664
BRD-K18856772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34996
A549_Selisistat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158423
GSE112995,GSE132079_1_v_3_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Exotropia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.308
BRD-K27915221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06008
A549_Hesperadin_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0219648
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE197555_0_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
Ciliated epithelial cell_Esophagus_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE139948_3_v_2_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Esophageal varix	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table8_gnomAD_AFR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
Ciliary vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.446
A549_Azacitidine_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0236337
GSE140937,GSE140938_0_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_CUDC-101_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0400119
CRCGN008_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.34695
BRD-K72060903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26935
GSE216043_11_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100576_HIP_dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.53654
BRD-K06997715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97183
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0111
MALME3M	DepMap CRISPR Gene Dependency	1.0	3.58194
A549_Decitabine_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159695
MCF7_PJ34_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141669
CRCGN016_MCF10A.TP53.M_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.13068
BRD-K31230200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16029
GLI-SUFU complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.736
A549_Ellagic acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171125
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Myelomeningocele	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
BRD-K22316029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29754
BRD-K99198579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12524
MCF7_CUDC-907_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128469
GSE112763,GSE112767_2_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K88831197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48317
GSE158834_11_v_3_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_JNJ-7706621_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203119
GSE174498,GSE174500_3_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE120612_7_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Apalutamide_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0224958
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
AE-85-KE62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200515
GSE189653,GSE203344_5_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K76788397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41047
SNU81	DepMap CRISPR Gene Dependency	1.0	6.63411
GSE156923_0_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	1.0	null
BIN67	DepMap CRISPR Gene Dependency	1.0	4.51349
GSE178340_5_v_4_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Choriocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.651
A549_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192005
AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE160304,GSE163392_4_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH226	DepMap CRISPR Gene Dependency	1.0	2.67764
A549_Ellagic acid_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0292127
A549_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184987
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272074
BRD-A19962819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04052
BRD-K12884811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20307
BRD-K20203758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96545
PPP4R1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04789
GSE88819_1_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Anencephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:M19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8288
Tooth	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.214
BRD-K29802952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.00182
Baraitser-Winter syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
SUDHL5	DepMap CRISPR Gene Dependency	1.0	3.79596
A549_PCI-34051_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130595
BRD-K62497619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38624
PMC9290241-13058_2022_1547_MOESM2_ESM.xlsx-Foglio1-Supplementary_Table_S1_Differentially_expressed_transcripts_in_common_between_EPZ-_and_MI-2-treated_MCF-7_cells_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0953
CRCGN014_HEPG2_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.98207
SNAI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46748
BRD-K48899005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19235
BRD-K72452130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08673
MCF7_EED226_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131727
SLC16A7+ cell_Lung_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE116930,GSE116935_3_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_BMS-911543_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203049
GSE211128_4_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
CREB3L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.793
A549_Tanespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191558
GSE166536_1_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165334_2_v_0_dabrafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Aminoglutethimide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167702
496100571_FWM_dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.01504
complete atrioventricular septal defect	MGI Mouse Phenotype Associations 2023	1.0	null
GSE171572_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239844_8_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
prenatal lethality, incomplete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
GSE101546_2_v_4_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114883_1_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Belinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.014536
A549_ITSA-1_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190076
PMC6225799-annrheumdis-2018-213524supp003.xlsx-Activated-state-LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K62182950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40781
BRD-K16376056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25622
Photoreceptor outer segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.076
A549_UNC1999_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169185
A549_Alisertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0112465
BRD-K62320774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76303
MCF7_Disulfiram_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165279
A549_JNJ-26854165_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186365
GSE198380_0_v_1_phgdh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153784
CRCGN014_HEPG2_3H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.00701
CRCGN009_HEPG2_24H:F07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30677
BRD-K53624506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38786
GSE159446,GSE159449_1_v_0_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230525
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.7358
Lymphatic system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.353
PMC4729482-pone.0146505.s004.xlsx-Sheet1-AR_associated_genes_identified_in_pRCC_not_ccRCC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4646
Senior-Loken syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.739
PMC6137307-mmc2.xlsx-STAT2-IFNa-Table_S1_STAT2-IFNa_Related_to_Figures_1_4_STAT2	Rummagene Transcription Factor Associations 2026	1.0	null
A549_PF-3845_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198436
BRD-K93386351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55915
GBR 12909	DeepCoverMOA Drug Mechanisms of Action	1.0	0.91
BRD-K25269762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46346
CRCGN011_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.88625
BRD-K86831676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55949
Hepatic vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.072
BBSome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.807
A549_GSK-LSD1 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150563
IC-05-AW29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223445
MCF7_PF-3845_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162191
BRD-K84800135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2839
HEXIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53171
BRD-K47292239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13617
A549_BRD4770_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014589
X-linked dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
BRD-K83815133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05127
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.356402
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Ki16425_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161865
GSE114883_0_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_BMS-911543_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0221513
Cystic kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.17
GSE214931_2_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151612_0_v_11_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A60513937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44511
NOS1	DepMap CRISPR Gene Dependency	1.0	2.31476
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227021
BRD-K00628863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55781
GSE220629_0_v_1_foxp3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
Stereocilium bundle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.122
A549_AMG-900_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119477
A549_Lenalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153672
Outer membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.839
BRD-K46141002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90184
GSE189356_5_v_6_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PPP1R3F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1932
GATD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32802
Axoneme	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.858
CRCGN014_HEPG2_3H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44098
PMC11465086-mmc2.xlsx-Table_ES_1_markers_c0_LPS_Vs_Co-Gene_Expression_Data_1_markers_c0_LPS_Vs_Control_related_to_Figure_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12032240-41598_2025_99253_MOESM1_ESM.docx-0-Genes_in_AR_inheritance_mode_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF605	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12441
A549_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0302391
PMC11409756-13062_2024_533_MOESM1_ESM.xlsx-Sheet1-Table_S1_Differentially_expressed_genes_DEGs_regulated_by_ZFP64_through_mRNA-seq_ZFP64	Rummagene Transcription Factor Associations 2026	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.94
misaligned sternebrae	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K36531580	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54802
GSE231720,GSE231724_3_v_0_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Amsacrine_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0214876
BRD-K86985145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53907
A549_Altretamine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0248501
GSE145639_7_v_4_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K74311661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02352
GSE186065_0_v_1_sirt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.04115
BRD-K03861440	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13225
A549_Glesatinib(MGCD265)_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0233402
A549_Givinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0234958
TMEM178A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16592
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:L09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.51975
Defactinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.47
GSE214823,GSE214824_0_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Dapagliflozin ((2S)-1,2-propanediol, hydrate)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0267428
TBX20	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5343
A549_Belinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0120514
A549_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167563
GSE223008_9_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Siponimod	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
Holzgreve-Wagner-Rehder Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.127
A549_G007-LK_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141528
GSE221539_1_v_3_lrrc10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nephronophthisis	ClinVar Gene-Phenotype Associations 2025	1.0	null
GSE163240_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199008
A549_AG-14361_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0247648
A549_TMP195_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195545
dilated renal tubule	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K36027285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13862
MCF7_Ivosidenib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137144
CRCGN014_HEPG2_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5883
GSE182680,GSE182683_10_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
SKF 89976A	DeepCoverMOA Drug Mechanisms of Action	1.0	0.31
betamethasone-dipropionate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20271
BRD-K98529522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46186
INSR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39571
A549_Raltitrexed_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130354
pulmonary hypoplasia	MGI Mouse Phenotype Associations 2023	1.0	null
GSE221327_4_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124029
A549_Toremifene Citrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0235802
BF-97-LS55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.425203
CRCGN016_MCF10A.TP53.M_24H:P18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75303
MCF7_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160956
MCF7_G007-LK_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157679
HT144SKINFV1	DepMap CRISPR Gene Dependency	1.0	2.29731
YC-45-JD42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207862
BRD-K33956247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.89793
GSE158458_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
muscular ventricular septal defect	MGI Mouse Phenotype Associations 2023	1.0	null
Brain - Cortex	GTEx Tissue Gene Expression Profiles 2023	1.0	2.04736
GSE221327_10_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IGROV1	DepMap CRISPR Gene Dependency	1.0	6.95845
decreased length of long bones	MGI Mouse Phenotype Associations 2023	1.0	null
GSE131377_4_v_2_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190947_1_v_0_xbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE235066_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DMTF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10743
GSE111660_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152441,GSE152442_7_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200646
MCF7_Fulvestrant_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136905
PMC9306206-12915_2022_1367_MOESM6_ESM.xlsx-Table_S7_-_JIP-Gene_SMAD4	Rummagene Transcription Factor Associations 2026	1.0	null
Finasteride	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
CHD4-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
FOXD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.2644
BRD-K40826084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35172
GSE120248,GSE120252_1_v_0_macf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Telotristat	DeepCoverMOA Drug Mechanisms of Action	1.0	1.93
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table3_WBBC_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5263239-mmc2.xls-THP-1_-_MLL-AF9-Non-spreading_targets_gene_names_1900_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
THYN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44086
A549_Filgotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.033202
GSE88819_1_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
decreased brain size	MGI Mouse Phenotype Associations 2023	1.0	null
NCIH23	DepMap CRISPR Gene Dependency	1.0	2.39018
GSE157594_6_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_BRD4770_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137974
Polydactyly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.846
MCF7_JQ1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141307
Runx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.709
GSE173997_1_v_0_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Divalproex Sodium_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0256218
GSE173201_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Resmetirom	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.39
BRD-K53619784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1474
BRD-K84128738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91966
PMC12339377-41587_2024_2403_MOESM3_ESM.xlsx-TableS6_LPS_screen_GEPs-Unnamed_32_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ERI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60162
Asphyxiating thoracic dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.24
RELA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0772
TC138	DepMap CRISPR Gene Dependency	1.0	4.87042
MCF7_Tubastatin A HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151142
CRCGN017_MCF10A.WT.HP_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0762
GSE182680,GSE182683_10_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Fasudil_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0414162
GSE238018_3_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.93128
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K41655405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45141
SB 218795	DeepCoverMOA Drug Mechanisms of Action	1.0	0.39
bacterial-type flagellum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.042
GSE217378_2_v_0_lin28b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POU2F1-35413990-HUMAN-ARPOSCRPROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K47995281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23669
WDR83OS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61076
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268977
A549_ITSA-1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0269277
BRD-K52566202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21663
Zofenopril	DeepCoverMOA Drug Mechanisms of Action	1.0	2.71
AZD-8055_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0226268
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.3883
A549_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202841
NOTCH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61052
BRD-K65752097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2689
Belinostat_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0154807
Kidney failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.288
BRD-K77053153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83648
Glycyrrhizic acid	DeepCoverMOA Drug Mechanisms of Action	1.0	0.21
GSE247862,GSE247863_2_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K76628522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19749
BRD-K17176016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23764
CRCGN015_MCF10A.WT.HP_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07335
Plasma membrane bounded cell projection cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.804
A549_MK-0752_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219485
BRD-K37584517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81166
GSE70935_2_v_4_cyfip1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_SRT3025 HCl_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140014
ESYT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11911
FD-29-MM50_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209487
A549_Abexinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130878
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186440,GSE186443_1_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MONOMAC1	DepMap CRISPR Gene Dependency	1.0	3.01438
CRCGN014_HEPG2_3H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3757
PNMA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20651
BRD-K10157835	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12653
Vilanterol_NCI-H23	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0152747
Neural tube defect	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.455
GSE189683_3_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Belinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154631
A549_BMS-536924_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0274959
PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE133087_1_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.652
A549_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205012
GSE245407,GSE245412_0_v_1_smurf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JA-26-YQ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209692
BRD-K22957824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58867
GSK1059615_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0347708
Meckel syndrome 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
GSE82032_3_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Divalproex Sodium_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169541
A549_Mesna_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0246662
SW403	DepMap CRISPR Gene Dependency	1.0	2.80901
A549_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165546
CRCGN009_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.26155
CRCGN010_HEPG2_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1798
PMC11408861-mmc2.pdf-9-CLOCK_CLOCK	Rummagene Transcription Factor Associations 2026	1.0	null
pulmonary valve atresia	MGI Mouse Phenotype Associations 2023	1.0	null
Joubert syndrome	ClinVar Gene-Phenotype Associations 2025	1.0	null
GSE130383_1_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hodgkin's lymphoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.353
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203862
GSE226983_1_v_0_ddx5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Six3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.6335
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_Jurkat_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
BE-38-UW72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289452
PROP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.6987
MCF7_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146489
BRD-K60692685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93658
GSE183113_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE117730,GSE117732_0_v_2_apobec2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE196104,GSE196106_3_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Raltitrexed_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0191517
A549_Pelitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165168
CDK9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15445
A549_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210077
Hydrolethalus syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.281
PMC10800016-table_s3_20230913_ddad186.xlsx-DUX4-aff_II-Unnamed_1_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
Hereditary spastic paraplegia 84	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.731
BRD-K10343715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.38412
A549_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.033083
A549_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194999
Dextrocardia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.345
MCF7_Gandotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143567
GSE213228_1_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.83
Loperamide (hydrochloride)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0183179
GSE223893_4_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150072,GSE169209_4_v_11_qser1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE176008_8_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TIPIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04817
polydactyly	MGI Mouse Phenotype Associations 2023	1.0	null
Peripheral blood stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.811
INTS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63854
abnormal tongue position	MGI Mouse Phenotype Associations 2023	1.0	null
A549_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161929
496100586_HIP_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.09579
A549_AT9283_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117908
PMC9314667-Table_1.xlsx-Regulons-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF454	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	130.04
5488_NCAPD3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06256
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.219
GSE203485_1_v_0_zdhhc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147876,GSE147877_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SMC1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53798
BRD-K24263752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11744
BRD-A52729710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17187
A549_Resveratrol_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178748
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE176008_4_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205550,GSE205552_2_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Bosutinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148221
GSE114232_10_v_11_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE144231_4_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE218580_1_v_4_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Global developmental delay	ClinVar Gene-Phenotype Associations 2025	1.0	null
A549_Rucaparib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0233324
PC-87-OG75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.312334
persistent truncus arteriosis	MGI Mouse Phenotype Associations 2023	1.0	null
GSE123734_1_v_0_mien1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K69241192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00062
PMC5848610-supp_gr.228809.117_Supplemental_Table_S4.xlsx-Table_S4D-Supplemental_Table_S4D_List_of_differentially_expressed_genes_upon_siZFX_with_promoters_bound_by_ZFX_in_C42B_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
VAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.986
Amelogenesis imperfecta type 1E	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
BRD-K82379643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45617
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7737
GSE162739_7_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TFDP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.004
BRD-K32176914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84111
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE218960_0_v_1_nrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VIRMA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2249
GSE145639_7_v_2_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
WASHC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38145
CRCGN012_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08836
GSE157383_3_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K50129495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17105
BRD-K71521842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04956
CRCGN016_MCF10A.WT.HP_24H:F13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4789
GSE147876,GSE147877_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Aurora A Inhibitor I_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135831
cilium organization	GO Biological Process Annotations 2023	1.0	null
GSE206342_1_v_0_kpna2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Townes-Brocks syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.053
3-Benzotriazol-propionic acid	DeepCoverMOA Drug Mechanisms of Action	1.0	0.23
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221854
BRD-K41719231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56985
GSE86507,GSE86509_4_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Motesanib Diphosphate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195056
GSE147210_2_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217115_2_v_0_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE218356_1_v_0_cited1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cleft lip	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.939
A549_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187067
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_SRT1720 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0374073
BRD-K41322154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36386
GSE108495_1_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
9+0 non-motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.941
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.931
GSE157555,GSE157556_3_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
NASP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46175
BRD-K35635390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05548
RISC-loading complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.739
Ciliary transition fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.195
GSE165548_2_v_13_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CB-46-FO63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230226
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287654
GSE214685_0_v_1_nsun2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168233_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal eye morphology	MGI Mouse Phenotype Associations 2023	1.0	null
PMC8566473-41467_2021_26653_MOESM3_ESM.xlsx-SOX2_interacting_proteins-Gene_symbol_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.301605
GSE231720,GSE231724_2_v_1_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K71647210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.47356
Leukocyte disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
Tongue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.702
GSE72895,GSE72896_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Ruxolitinib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145507
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.329258
BRD-K36445086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32362
A549_Veliparib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193797
Tofacitinib_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0249837
A549_TGX-221_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019789
BRD-K40876208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37284
A549_Tanespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240403
Naproxen_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0217928
A549_AT9283_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163147
Terminal bronchiole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.856
BCL6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35222
Joubert syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.334
Joubert syndrome 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.853
A549_Tazemetostat_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136744
TEC	Kinase Library Tyrosine Kinome Atlas	1.0	98.05
GSE86813,GSE86814_0_v_1_atf7ip_human	RummaGEO Gene Perturbation Signatures	1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE153757,GSE153758_1_v_3_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134948
MCF7_Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.012162
BRD-K32118188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08311
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF-_SURVIVAL-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
Clara cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.941
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
XRK3F2_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0156504
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.57255
BRD-K32173944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22325
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9637
MCF7_Bisindolylmaleimide IX_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0113853
A549_Barasertib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.013131
Fer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.695
MCF7_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141501
split sternum	MGI Mouse Phenotype Associations 2023	1.0	null
APD668	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
BRD-K28995832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99326
GSE90552_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Nintedanib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127334
BRD-K50443235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.00732
Meckel syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.549
PMC11257629-media-9.xls-METTL3_KD_upregulated_Genes-METTL3KD_UPregulated_Genes_1694_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K82619993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27102
Dorsal lip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.53
A549_Droxinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180771
A549_PFI-1_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0225762
gamma-tubulin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.121
GSE133213_6_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Anterior horn cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.602
A549_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0439981
BRD-K64797043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0316
NA-30-HS87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273665
BB-45-NH69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212075
PMC10714175-mmc2.xlsx-KD_Gene_list-Supplemental_Table_3_FAM13B_knockdown_mediated_changes_in_gene_expression_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Medullary collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.714
PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_with_decrease_in_MLL-AF4_ChIP-seq_signal_2198_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE244072_10_v_8_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Apraxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.889
GSE61117_0_v_1_trim24_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9455
TMEM68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19304
A549_JNJ-7706621_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143698
CRCGN009_HEPG2_24H:L07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7297
CRCGN011_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5661
CRCGN009_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.89499
GSE145215_0_v_3_krt13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Anacardic Acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169384
BRD-K82774801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.29382
A549_Triamcinolone Acetonide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139921
BRD-K03715233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77937
GSE94814_2_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K86454955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14863
A549_Pracinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0220533
BRD-K27723822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08945
abnormal tongue morphology	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K10849007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15443
BRD-K62256869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13695
GSE147210_3_v_4_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ONECUT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6888
A549_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196763
CRCGN016_MCF10A.WT.HP_24H:J05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02828
GSE246660_1_v_0_glycerol_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_JQ1_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0309973
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9159
MCF7_M344_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207966
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2835
CMK115	DepMap CRISPR Gene Dependency	1.0	4.65944
BRD-K69077676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50924
QE-18-WG07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220257
BRD-K01853388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76047
Congenital heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.534
CRCGN014_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5489
Epirubicin (hydrochloride)_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0390932
BRD-K26992703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04633
GSE161055,GSE161056_1_v_0_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pontocerebellar hypoplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.37
PMC8494348-pone.0257161.s002.xlsx-D20-OXT_ext_D20-OXT_NOT_ext-Gene_Name_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0204
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_prom_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Joubert syndrome 21	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.366
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5146
GSE147366_1_v_4_med13_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150072,GSE169209_6_v_11_qser1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Azacitidine_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196396
Nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
Chorionic villus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.028
A549_Fasudil_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182359
RELL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32824
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Iniparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160588
GSE88819_1_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184856
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table7_gnomAD_AMR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
atrioventricular valve regurgitation	MGI Mouse Phenotype Associations 2023	1.0	null
A549_Curcumin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.022012
BRD-K42247636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95781
GSE74251_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF_Q1_vs_Q4-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE176008_8_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ciliopathies	WikiPathways Pathways 2024	1.0	null
Fusidic acid_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.017233
SAMD14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61404
GSE212848_1_v_0_pum1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE165682_0_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ciliary basal body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.395
Bardet-Biedl syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.159
A549_UNC1999_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0273677
Retinitis pigmentosa 23	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.389
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.072
BRD-K24877937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.46183
GSE118077_7_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Trifluridine_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0175857
PMC5668942-supp_gr.216721.116_Supplemental_Data_S2.xlsx-Artery_Tibial_IR-TE-SRCAP_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
A549_PHA-680632_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144175
bacterial-type flagellum hook	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.363
GSE147240_3_v_4_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Pirarubicin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013517
Polyhydramnios	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217387
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7264
MCF7_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0226436
GSE221327_6_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K83297764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15714
BRD-K72561299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09731
PMC5029704-oncotarget-07-24326-s006.xlsx-Sheet1-Genes_that_are_downregulated_in_low_TET1_compared_to_high_TET1_TET1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN013_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.62683
GSE118077_7_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
SLIK (SAGA-like) complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.843
GSE213715_0_v_1_iqgap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K95153427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89633
Orofaciodigital syndrome I	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.324
BRD-K46082763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05775
Ellis-Van Creveld syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.539
BRD-K77272277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29372
Hydrocephalus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.468
MCF7_Entinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181472
abnormal vertebrae morphology	MGI Mouse Phenotype Associations 2023	1.0	null
Tubulin inhibitor 6_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0205793
PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-SP1_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
(R)-Verapamil (hydrochloride)_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0211827
Hodgkin's lymphoma	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.13979
BRD-K98245381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04349
BRD-K13445266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02123
CRCGN017_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7123
RMUGS	DepMap CRISPR Gene Dependency	1.0	3.04375
GSE116930,GSE116935_3_v_6_hes7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Holoprosencephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.467
BRD-K59587063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22135
TE-15-RO34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226983
GSE111035,GSE111040_3_v_13_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K53772256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18964
PMC9618568-41467_2022_34255_MOESM4_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
RNF34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28943
Bone structure disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
GSE231648_1_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120216_3_v_0_cbfb_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE208171_0_v_1_zc4h2_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Trichostatin A_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0255574
GSE110440_1_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE238018_1_v_0_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210476_2_v_7_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE209898,GSE209899_0_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cerebellar disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.443
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NES-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
octreotide	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49625
8405_SRFBP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.31434
GSE127790_10_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_G007-LK_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0275612
BRD-K88179337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28016
GSE182680,GSE182683_10_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Chromosome 15q11.2 deletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
GSE201239_0_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE261563_9_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K21997380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84028
Lm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.845
GSE135030_8_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Fulvestrant_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0108272
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.69645
GSE149901_2_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Meloxicam_NCI-H23	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0189691
BRD-K05392698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42302
BRD-K79551673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08278
arl6	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.448
GSE94849_6_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K99939253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13246
A549_Entacapone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166029
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20109
Typical Joubert syndrome MRI findings	ClinVar Gene-Phenotype Associations 2025	1.0	null
GSE120612_7_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_INO-1001_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0240115
A549_A-366_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0222204
CRCGN010_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.9588
WDR20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11898
GSE165274_1_v_2_poldip2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151612_4_v_11_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cerebellum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCF7_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182582
A549_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0274831
A549_Cimetidine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015888
BRD-K21139023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44021
GSE115364_0_v_1_idh3a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE225869_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE244072_10_v_7_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.3309
MCF7_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146463
BRD-K63787803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.38874
Finasteride_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0204471
BRD-K90697694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.12428
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3919
CRCGN014_HEPG2_3H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.24665
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
COMA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.566
NSC 23766	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297051
A549_JQ1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149328
CRCGN011_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48105
Maraviroc	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Fluorouracil_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197622
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_JK_LPS-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
VB-89-RG34_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203342
BRD-K17062413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.37077
MCF7_Obatoclax Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133081
BRD-K67270926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31793
A549_Lapatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170836
BRD-K24377650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46797
BRD-K94790210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4773
PHOX2B-30127528-KELLY-HUMAN-BRAINNEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Meckel syndrome 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.37
PMC9643473-Table1.xls-MAF_0_005-Gene_refGeneWithVer_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE131377_1_v_3_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hydrops fetalis	MGI Mouse Phenotype Associations 2023	1.0	null
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Divalproex Sodium_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143307
BRD-K25305749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30142
BRD-A07861932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44125
BRD-K35026224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13174
BRD-A90289676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51595
GSE239844_4_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
common atrium	MGI Mouse Phenotype Associations 2023	1.0	null
GSE124694_0_v_1_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_PCI-34051_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0232617
GSE133516_0_v_1_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
Orofaciodigital syndrome	ClinVar Gene-Phenotype Associations 2025	1.0	null
A549_Luminespib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131737
GSE205976,GSE205978_2_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE200352_10_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279466
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9468
A549_EED226_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150726
Metencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K77953978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13278
GSE78199_0_v_3_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Celecoxib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139624
Thyroid cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.007
PMC10891378-tau-13-01-91-supplementary.pdf-17-TBX1_TBX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE203158_1_v_13_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE173232_1_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Ki16425_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023641
BRD-K00530465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27095
Leptomeninx	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.114
GSE200352_5_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE214823,GSE214824_0_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AZD-8055_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0231625
CRCGN013_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9569
A549_BMS-911543_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0275822
BRD-K39460811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5227
BRD-K63950697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21411
A549_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146572
GSE169152_3_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.053
Portal hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.146
BRD-K47109712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82786
PSME1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27144
BRD-K07409609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71159
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4219345-1471-2121-14-52-S3.xlsx-BORIS_hNP1-Gene_Symbol_CTCFL	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table5_gnomAD_SAS_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K79152256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45548
GSE103068_0_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Entinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171513
GSE218819_2_v_1_kdm5b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LIVF001-021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28992
BRD-K67702605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43612
FUT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55401
BRD-K61661017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33818
Hematologic cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.353
Foot	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.18
496100358_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.08197
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.396464
BRD-K18863894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73258
ZFP14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.8662
NOB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78258
BRD-K45563993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34116
duplex kidney	MGI Mouse Phenotype Associations 2023	1.0	null
USP19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85239
CRCGN016_MCF10A.TP53.M_24H:D03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.64115
GSE154577_6_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CDX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.0873
A549_Mercaptopurine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018059
GSE229973_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Joubert syndrome and related disorders	ClinVar Gene-Phenotype Associations 2025	1.0	null
A549_Abexinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0259713
PCDHB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09703
PMC10353540-Table_1.xlsx-HCC1954_AR_vs_HCC1954_A-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ROS50	DepMap CRISPR Gene Dependency	1.0	5.56674
BRD-K05718365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00385
PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-NFATC3_mod_NFATC3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE225869_3_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_CYC116_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0237078
A549_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0220408
PMC12021535-CPH4-15-e70011-s001.xlsx-S21-KLF2_KLF2	Rummagene Transcription Factor Associations 2026	1.0	null
cilium assembly	GO Biological Process Annotations 2023	1.0	null
GSE226285_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0544
short-rib thoracic dysplasia 6 with or without polydactyly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.231
GSE143944_2_v_3_ribociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235066_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205976,GSE205978_1_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Limb bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.947
PMC6887651-Table_1.xlsx-Sheet1-SRY_SRY	Rummagene Transcription Factor Associations 2026	1.0	null
A549_FLLL32_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0293478
BMS-911543	DeepCoverMOA Drug Mechanisms of Action	1.0	2.13
A549_Fluorouracil_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0310025
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_AZ 960_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195129
Monopodium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.307
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
Centrosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.711
A549_Motesanib Diphosphate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019718
MCF7_Cimetidine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150732
PMC5865663-oncotarget-09-14193-s002.docx-0-Supplementary_Table_S2_Somatic_mutation_Genes_which_are_high_frequency_in_TP53_signature_MT_TCGA_data_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Entacapone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0287298
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240896
KP1N	DepMap CRISPR Gene Dependency	1.0	2.13528
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Sodium Phenylbutyrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209252
GSE224969,GSE224971_3_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cleft upper lip	MGI Mouse Phenotype Associations 2023	1.0	null
GSE101537_1_v_3_neurog3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K52551495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27195
Chromosome 5p13 duplication syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.198
A549_Costunolide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160733
PMC6599263-13073_2019_654_MOESM2_ESM.xlsx-CAR1_tsv-gene_name_NR1I3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K83238251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35247
A549_Hesperadin_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0289444
CRCGN010_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67846
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_AZD1480_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149185
MCF7_Luminespib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161255
organelle assembly	GO Biological Process Annotations 2023	1.0	null
abnormal cerebellum morphology	MGI Mouse Phenotype Associations 2023	1.0	null
LHX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21191
SPSB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28105
SC5D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25819
pantothenic-acid	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39783
BRD-K76318449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17835
GSE143944_1_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Alisertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.021635
Lip disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.695
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05899
GSE104022_3_v_7_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Situs inversus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.738
BRD-K85307083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0808
CRCGN015_MCF10A.WT.HP_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04256
PMC2813300-pone.0008960.s011.xls-SOX2_squamous_signature-Gene_Symbol_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K46121327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30781
GSE221327_10_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_JQ1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.020187
Nephronophthisis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.39
GSE210476_11_v_7_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_PF-573228_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140036
GSE221327_8_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Polymicrogyria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.784
A549_SRT3025 HCl_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132612
Scoliosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.073
A549_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0246325
PMC10534007-Table_2.xlsx-S2_overlap_MSC_down_B_V-395_common_elements_in_VM-CUB1_MSC_down_and_BFTC905_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K96510191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81912
GSE200320_1_v_0_mfge8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Coloboma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.335
A549_Givinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014905
HC-01-FD24_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226016
double outlet right ventricle	MGI Mouse Phenotype Associations 2023	1.0	null
NR1H4::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1033
RS 67333	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.39
MCF7_Bisindolylmaleimide IX_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150891
GSE221327_6_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Retinitis pigmentosa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.432
BRD-K28720546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50076
BRD-K12986423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45202
Nephronophthisis 11	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
GSE210225_0_v_1_uba6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.312642
BRD-K69840402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34397
Lenalidomide (hemihydrate)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.027253
MCF7_Raltitrexed_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195823
Bone development disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.02
GSE147056_0_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210101,GSE210114_0_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
NR3C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4699
GSE112860_3_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_GSK J1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159323
GSE57875_1_v_0_hnrnpl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Quinidine (15% dihydroquinidine)_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0259288
GSE114883_0_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DUXA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7273
Hair root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.925
TUBG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39878
GSE147366_1_v_2_med13_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_WHI-P154_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016811
BRD-K94088431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11542
A549_Roxadustat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0273167
BRD-K81515704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46903
GSE63048_11_v_12_morc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K42496940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15189
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE144231_4_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K21568472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08359
KA-75-LP02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22916
A549_Roxadustat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0218328
alvimopan	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.64
PMC8384902-mmc5.xlsx-H128_ASCL1_ChIP-Symbol_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
External ectoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.941
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.353
GSE254649_3_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142861
BRD-K44363090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.2968
BRD-K97588749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88325
GSE226091,GSE226092_0_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
preweaning lethality, complete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
Intraciliary transport particle B	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.74
A549_Selisistat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0352598
CRCGN012_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7504
Type I spiral ganglion neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Toe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.413
BRD-K30171122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14575
GSE147876,GSE147877_4_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE166315_1_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K52620056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03381
Retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.637
Joubert syndrome	WikiPathways Pathways 2024	1.0	null
Cranial nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
BRD-K03089783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51821
CRCGN013_HEPG2_24H:B19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.107
GSE193258,GSE193259_9_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE63857_3_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
k29	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.797
MCF7_Gandotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173136
A549_ITSA-1_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0302182
GSE210101,GSE210114_11_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Belumosudil (mesylate)_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00994037
BRD-K27616520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76454
A549_Lenalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0240902
BRD-K43992612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57858
BRD-K47441131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09235
A549_Obatoclax Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019251
GSE238116_3_v_0_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE71491_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PPP1R13L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34463
decreased birth body size	MGI Mouse Phenotype Associations 2023	1.0	null
GSE89018_12_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pericentriolar material	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.868
GSE202587_1_v_0_xrn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DD-74-PJ26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.366483
BRD-K18562194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05993
GSE111660_1_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Elagolix sodium_NCI-H460	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00778616
GSE147876,GSE147877_4_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239844_6_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
C19orf53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05229
PMC8283158-mmc2.xlsx-TCF4_NPC-Gene_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE63048_11_v_5_morc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_JNJ-26854165_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.011604
GSE250534_0_v_3_cabergoline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K37912617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31237
Blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.221
MCF7_AG-14361_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140374
A549_Selisistat_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208815
GSE210101,GSE210114_7_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE94849_6_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K87159315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23152
GSE147876,GSE147877_4_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE153871_5_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_MC1568_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148607
PMC4729482-pone.0146505.s001.xlsx-Sheet1-pRCC_positively_associated_with_AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K73001304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28949
A549_Ruxolitinib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0303442
Tropicamide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-2.27
GSE202587_1_v_2_xrn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158096
A549_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145457
MCF7_Maraviroc_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144343
BRD-K87176777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1768
Brain - Putamen (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.02972
KMS20	DepMap CRISPR Gene Dependency	1.0	2.56339
BRD-K28803288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19757
BRD-K36468214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4236
Anacetrapib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
BRD-K59134599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05454
GSE151782_2_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12498101-cd-24-1904_supplementary_tables_s1-s12_suppst1.xlsx-S7-Supplementary_Table_7_Human_tissue_RNA-seq_differential_analysis_for_SPOPmut_vs_SPOPwt_AA_vs_AG_and_AG_vs_GG_clone_data_DEG_set_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Ocular motility disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.322
CRCGN009_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0212
BRD-K61022988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40158
GSE159473_0_v_1_eif5a2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K31660953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03434
GSE86507,GSE86509_7_v_2_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152441,GSE152442_6_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE199255,GSE199356_4_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9882185-media-4.xlsx-Neuron_KD-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182680,GSE182683_5_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.322
MCF7_Ellagic acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014793
A549_Regorafenib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0282766
Orofaciodigital syndrome IV	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.412
BRD-K19066553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05293
A549_Busulfan_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0229268
MCF7_Fulvestrant_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0106926
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263367
GSE226544_1_v_0_hnrnpa2b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K42713448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08842
Cleft palate	ClinVar Gene-Phenotype Associations 2025	1.0	null
BRD-K89801935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.66789
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR	Rummagene Transcription Factor Associations 2026	1.0	null
t61-colon_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.60293
TBR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7126
abnormal thoracic cage morphology	MGI Mouse Phenotype Associations 2023	1.0	null
GSE169713,GSE169715_3_v_2_tert_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:M12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19477
BRD-K50575036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20113
Asarone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.56
GSE203308_1_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K85775326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1764
GSE218060_7_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Joubert syndrome	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
TUBGCP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17338
A549_Temsirolimus_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161914
A549_MC1568_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174132
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.1436
GSE165682_2_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7218
Lung	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Ponatinib_NCI-H23	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0278827
496100363_TCx_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.46665
Mouth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.358
GTEx Muscle 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	16.0355
A549_Barasertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170262
BRD-K08995282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2105
Centriole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.844
BRD-K67137502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41175
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0533
FBLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62591
GSE174735_4_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5462
Ciliary tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.17
BRD-K57226184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01974
GSE133329_0_v_3_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K97486995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23791
GSE210101,GSE210114_7_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233548_2_v_0_plscr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K97842654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24563
Microphthalmia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.525
Syndactyly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.858
BRD-K47366416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05764
5-R-Rivaroxaban	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.46
CDX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0256
CRCGN015_MCF10A_48H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5568
CRCGN008_HEPG2_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20355
GSE239578_0_v_4_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Extraocular muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.731
BRD-K69699301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10473
MKS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.396
Agenesis of the corpus callosum with peripheral neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.163
GSE130401_4_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Enzastaurin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0229506
A549_Tranylcypromine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180346
BRD-K07160586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20405
BRD-K38788176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98117
GSE233183,GSE233187_2_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Disulfiram_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168316
BRD-K94401439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05657
BRD-K95815724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56555
2105_DDX18_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.35078
BRD-A38066207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06995
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.046
A549_UNC0379_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147438
BRD-K83544408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27928
cilium organization	GO Biological Process Annotations 2025	1.0	null
Telomere length	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.552288
GSE222758_0_v_3_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE221327_6_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
aortic valve regurgitation	MGI Mouse Phenotype Associations 2023	1.0	null
A549_AZD1480_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213729
A549_Tucidinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159622
GSE233566_1_v_2_braf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_A-366_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142551
A549_Dasatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210665
GSE153757,GSE153758_0_v_2_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171269_1_v_4_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Veliparib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130358
FAM162A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08807
MCF7_Patupilone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133242
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0104266
Eye degenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.722
Craniosynostosis syndrome	ClinVar Gene-Phenotype Associations 2025	1.0	null
LUBIPROSTONE	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.52
Autosomal recessive polycystic kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.697
PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_PFI-1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176973
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K32231853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1095
A549_SB431542_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166733
MCF7_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139663
9-ING-41_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0204124
GSE169152_5_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DD-74-PJ26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224749
A549_ZM 447439_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172189
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K47200630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6685
MEF2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0423
BRD-K80009401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38343
BRD-K76543697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66661
MCF7_Tanespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133105
BRD-A09988375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26179
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_Luminespib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169418
OTS514_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0175222
A549_Dasatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0242793
A549_CEP-33779_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147031
DNAJC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91877
Acrocephalosyndactylia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.071
GSE125014_6_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sulfisoxazole_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0142737
preaxial polydactyly	MGI Mouse Phenotype Associations 2023	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
BRD-K17675814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90868
MCF7_Ki8751_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141519
Intraciliary transport particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.024
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305443
MCF7_Tubastatin A HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0225247
MCF7_Tozasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016939
Syndrome	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
CRCGN015_MCF10A.WT.HP_24H:P17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32686
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_1_TRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K38519585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81115
A549_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186609
GSE123372,GSE123373_10_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ciliary base	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.691
GSE187006_3_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_SRT2104_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126969
MCF7_ABT-737_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190376
MCF7_PF-3845_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187495
CRCGN016_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26278
Palate	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.749
BRD-K09388706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37017
A549_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208346
GSE110268_2_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226770_1_v_6_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
HUPT4	DepMap CRISPR Gene Dependency	1.0	3.29506
GSE151782_1_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Chromosomal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.085
HOXD9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6467
A549_WP1066_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016748
BRD-K37480258	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1171
GSE220520_5_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE176008_4_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6137307-mmc2.xlsx-IRF9-IFNa-Table_S1_IRF9-IFNa_Related_to_Figure_1_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
A549_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0265808
GSE175787_4_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169152_3_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Resveratrol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145126
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.501
GSE147876,GSE147877_2_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Hallux	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.594
CRCGN016_MCF10A.TP53.M_24H:O09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10341
EN	DepMap CRISPR Gene Dependency	1.0	2.71177
BRD-K92806245	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12332
GSE192663_3_v_5_acly_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Barasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162271
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ventricular septal defect	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K86155080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.4418
BRD-K62967214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12046
Greig cephalopolysyndactyly syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.623
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.320595
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208748
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.80424
microcephaly, short stature, and limb abnormalities	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.135
GSE180377_2_v_1_lipa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161527
BRD-K65494150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28899
A549_Navitoclax_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148452
BRD-K98772859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27006
Arthrogryposis multiplex congenita-6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.423
A549_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133453
GSE103068_0_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Auditory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.026
Inner ear disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
ERP44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44849
BRD-K63654001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1911
A549_BMS-265246_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0103755
BRD-K33953218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.46527
BRD-K81728234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04697
Adams apple	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.5
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12178829-mmc4.xlsx-Sheet_3-MEG3-KD_Down-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211226_1_v_0_sirpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Fasudil_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0120408
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.353
PTPRA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4392
GSE176008_7_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K24669989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49617
BRD-A05883068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36909
A549_Streptozotocin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015196
IFT122	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60803
Meckel syndrome 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205957
Fourth ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.331
Asphyxiating thoracic dystrophy 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.034
THOC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74732
DDIAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4676
PSS008	DepMap CRISPR Gene Dependency	1.0	3.19609
A549_Tozasertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183489
A549_Ki16425_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0251415
MCF7_GSK1070916_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118153
MCF7_GSK-LSD1 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162073
GSE216043_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cell projection membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.405
GSE147876,GSE147877_4_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AE-13-CX28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202921
GSE221327_8_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE183113_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K27109474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54929
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.844
A549_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181553
Periciliary membrane compartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.621
HD-26-KX74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205953
A549_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0384219
A549_BMS-911543_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144096
GSE213588_9_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE138001_5_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9855
A549_Disulfiram_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.022408
PF429242	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Corpus callosum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.665
A549_Andarine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0324061
GSE221327_8_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59931
BRD-K40532221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17847
GSE248045,GSE248046_6_v_2_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
BRD-K93752373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2836
A549_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224779
PMC12224833-12967_2025_6787_MOESM3_ESM.xlsx-DEGs_PDX1-GeneSymbol_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K85741537	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17152
Spina bifida	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.094
BRD-K00793226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1787
496100347_PCx_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.72043
HMX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78905
BRD-K46961295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42475
GSE231648_0_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3472
A549_CEP-33779_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0275084
A549_Flavopiridol HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156489
CRCGN017_MCF10A.WT.HP_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35624
GSE114883_1_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100382_PCx_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01672
CRCGN014_HEPG2_3H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.33755
A549_MLN8054_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134478
BRD-A64849281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10485
BRD-K94132559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42016
DESI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55118
MCF7_Curcumin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139548
GSE221327_4_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE89057_0_v_1_sox5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_IOX2_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182309
Severe congenital neutropenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.338
BRD-K22390389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20605
mandible hypoplasia	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K35442564	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39774
GSE169152_3_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Central nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
BRD-K86981519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07249
BRD-K12866026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50888
SRSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00851
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.431066
A549_SL-327_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144538
Imperforate anus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.318
AA-86-YY62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322314
A549_ABT-737_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016388
Joubert syndrome with orofaciodigital defect	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.184
CAOV3	DepMap CRISPR Gene Dependency	1.0	2.09983
Cervix - Ectocervix	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.909382
BRD-K73451279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17911
Esotropia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.43
A549_ZM 447439_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116075
BRD-K44576681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48758
BRD-K75857911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86658
GSE74251_2_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Inner medullary collecting duct cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.917
A549_Vandetanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190121
A549_Divalproex Sodium_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199861
CRCGN015_MCF10A.TP53.M_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60655
PMC9643473-Table1.xls-MAF_0_005-Gene_refGenecanonical_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K78363521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31723
GSE155852_0_v_1_apigenin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211983_1_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
496100665_PCx_probable Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.33585
BRD-K44167510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14449
MCF7_JNJ-7706621_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155313
BRD-A47109850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14302
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.947
Placenta disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.054
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.383989
Chronic kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
A549_Cimetidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151778
Clofarabine_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0236692
PMC8423434-mmc7.xlsx-KLF4_HENSM-Genes_n_2172_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE200099_3_v_1_honokiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE145628,GSE145629_1_v_0_myrf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.18
Sclerocornea	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.168
PMC12339377-41587_2024_2403_MOESM3_ESM.xlsx-TableS6_LPS_screen_GEPs-Unnamed_8_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE102187_0_v_1_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193258,GSE193259_5_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_Obatoclax Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0238656
9+2 non-motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.643
GSE234340_10_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.435
GSE88819_11_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Roxadustat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209168
BRD-K95321016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07404
A549_Anacardic Acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0293279
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.398574
MCF7_Daphnetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0251081
Ciliary necklace	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.235
MCF7_Azacitidine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144555
BRD-K27406233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51907
GSE193258,GSE193259_9_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K05841284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40641
Developmental and epileptic encephalopathy 86	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.306
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_SB431542_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.03255
CTPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22318
MCF7_A-366_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146539
OSBPL1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00572
Joubert syndrome 17	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.842
Combined oxidative phosphorylation deficiency 10	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.194
A549_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017696
GSE184210_0_v_3_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.469
BRD-K07276022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13459
BRD-K26026745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41931
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K93316985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12807
GSE250534_4_v_1_cabergoline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Thromboangiitis obliterans	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
MCF7_Vandetanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141859
CRCGN016_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.0262
Joubert syndrome 10	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.863
BRD-K75821161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10137
MCF7_Toremifene Citrate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176138
GSE161064,GSE161065_0_v_1_kdm5b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Digenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.243
A549_PFI-1_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179797
SGSH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07957
Larotrectinib_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0331629
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263353
GSE193258,GSE193259_9_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
IRS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29074
Lomitapide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
A549_Tubastatin A HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176447
Cyst	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.344
BRD-K23975481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87795
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7635
BRD-K41206520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0488
organelle assembly	GO Biological Process Annotations 2025	1.0	null
BRD-K50058129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38428
A549_SGI-1776 free base_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142897
BRD-K56893290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59618
Ciliary shaft	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.535
GLB1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23384
Ciliary membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.725
GSE232261,GSE232263_0_v_1_usf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K99525048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29021
GSE123502,GSE123504_1_v_0_chd4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11067031-pnas.2317690121.sd06.xlsx-gene_list_14_txt-Differentially_expressed_genes_between_PML_RARA_GFP_vs_C88A_PML_RARA_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
Jaundice	ClinVar Gene-Phenotype Associations 2025	1.0	null
GSE94849_1_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE221327_10_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3476
PMC12178829-mmc4.xlsx-Sheet_3-MEG3-KD_Down-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HOXC13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5269
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
DUX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.4335
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Olcegepant	DeepCoverMOA Drug Mechanisms of Action	1.0	0.31
X-linked monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
BRD-A16313205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20025
BTK	Kinase Library Tyrosine Kinome Atlas	1.0	97.33
ZNF330	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45844
BRD-K50345393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1295
Centriolar satellite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.347
BRD-K90059152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42245
GSE179138_4_v_1_lama4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ATP5MGL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33349
BRD-K58324650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21123
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273707
BX 471	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
GSE144796_3_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Pronephric tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.324
MCF7_Rucaparib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013182
BRD-K51643438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09211
BRD-K98016463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05877
SLX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74728
CRCGN015_MCF10A.WT.HP_24H:C14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21192
Developmental and epileptic encephalopathy 42	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.267
Neratinib_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0357082
GSE85995_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brivudine_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.028608
cilium assembly	GO Biological Process Annotations 2025	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_U87MG_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Postaxial acrofacial dysostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
Leber congenital amaurosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.691
Neural tube	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.31
PMC9529122-pone.0274785.s002.xlsx-S1_Table-S1A_Table_Differentially_expressed_genes_in_HeyA8_overexpressin_ZNF521_vs_HeyA8_control_cells_ZNF521	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K57382977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09804
BRD-K03923461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55484
A549_Resveratrol_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0445987
GSE157594_6_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
emetine-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08547
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205163,GSE205164_9_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_UNC1999_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0350464
Congenital nervous system abnormality	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.64
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K81642886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25221
MCF7_TG101209_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124503
BRD-K76885311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02331
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K16570418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17485
LY 487379	DeepCoverMOA Drug Mechanisms of Action	1.0	0.74
BRD-K65860773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60176
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8637
Balicatib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.88
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-circARID1A_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.457
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE144443_10_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242333_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Pracinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152981
Joubert syndrome 14	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.298
CYRIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10819
A549_Tranylcypromine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212482
A549_Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177772
BRD-K90655269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89864
Joubert syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
A549_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153637
A549_Bisindolylmaleimide IX_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0236424
BRD-K73357447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30975
GSE193258,GSE193259_9_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11408518-41598_2024_73146_MOESM5_ESM.xlsx-Intersection_gene-NCOA1_NCOA1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K39688447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11406
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-fromNode_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Trametinib_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0232199
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cleft palate	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.697
BRD-K19315592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74307
Polycystic kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.905
GSE134375_3_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135514_8_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012236
A549_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0218282
CCDC28B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43288
GSE125007,GSE125008_10_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE133763_0_v_1_chd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.286
A549_PHA-680632_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116705
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.026
MCF7_Selisistat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013586
Neutropenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.303
PMC10684515-41467_2023_43264_MOESM7_ESM.xlsx-HOXA9_ChIP-seq_peaks_in_SEM-Gene_2kb_HOXA9	Rummagene Transcription Factor Associations 2026	1.0	null
GSE207135_1_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K17705318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73225
A549_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016299
(4-Chlorobenzyl)pyridine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.62
Cerebellar hypoplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.804
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NLS-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K28820796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35821
Monogenic disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
Lymphoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.353
A549_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0252875
BRD-A90450579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13215
GSE147876,GSE147877_4_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE153871_5_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Pelitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0120987
Severe congenital neutropenia 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.498
BC-00-YH62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246596
Stereocilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.152
A549_Toremifene Citrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0249129
MCF7_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.023663
USP44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57909
BRD-K35209334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91737
MCF7_Baricitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0220711
A549_Ki8751_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159441
GSE223893_1_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Orofacial cleft	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.974
CLK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41745
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22453
Gonocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.578
GSE144231_3_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cerebral degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.399
NE-37-JX51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204953
MCF7_Lenalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140338
BRD-K52924481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10407
Edwards syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
BRD-K23029982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75345
BRD-K31377965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03308
Familial meningioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.253
A549_Flavopiridol HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180971
BRD-K34907403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71198
COACH syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.451
absent colon	MGI Mouse Phenotype Associations 2023	1.0	null
Disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
BRD-K29298614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49292
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE203158_1_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K17152303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15256
MED31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38419
BRD-K73574487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61148
GSE221327_4_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE190947_2_v_0_xbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_JNJ-7706621_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127061
MCF7_Alvespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156332
BRD-K86268010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14746
A549_Bisindolylmaleimide IX_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0260021
NMCG1	DepMap CRISPR Gene Dependency	1.0	3.7651
GSE214505_0_v_1_akr1b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE228430_1_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9882185-media-4.xlsx-Neuron_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Asphyxiating thoracic dystrophy 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.32
MCF7_S3I-201_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207272
Mitochondrial intermembrane space protein transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.696
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232785
GSE144231_6_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210225_0_v_1_inosine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Cleft lip	ClinVar Gene-Phenotype Associations 2025	1.0	null
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152432_3_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_2-Methoxyestradiol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0279087
GSE235701,GSE261434_2_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Artery - Tibial	GTEx Tissue Gene Expression Profiles 2023	1.0	1.99978
BRD-K91120514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58335
BRD-K68547601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06593
A549_AT9283_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163071
GSE147056_3_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.319
TC205	DepMap CRISPR Gene Dependency	1.0	2.84765
preweaning lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K83487481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39972
Immune system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.353
abnormal intestine development	MGI Mouse Phenotype Associations 2023	1.0	null
Amblyopia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
BRD-K11581306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50463
GSE147876,GSE147877_2_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.353
BRD-K05846874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0625
Meningocele	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.16
Skin - Sun Exposed (Lower leg)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.83102
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.582975
MCF7_Tranylcypromine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204616
MCF7_Raltitrexed_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0236492
GSE166004_5_v_4_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_AZ 960_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144904
GSE214596,GSE214598_1_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Joubert syndrome 29	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.897
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE219195_4_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135030_8_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Divalproex Sodium_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0316555
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.167
PPP1R3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70362
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199644_3_v_2_palmitic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_IOX2_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150723
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Fundus dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.137
A549_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158299
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314174
MCF7_Abexinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181465
GSE213611_1_v_0_nuf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184892_6_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
pulmonary artery hypoplasia	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K35049668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45356
CRCGN017_MCF10A.TP53.M_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.49119
GSE224294_4_v_2_ngly1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MEIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.2736
LTK	Kinase Library Tyrosine Kinome Atlas	1.0	98.56
Pramipexole	DeepCoverMOA Drug Mechanisms of Action	1.0	2.08
BRD-K93537437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77944
A549_Ellagic acid_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194721
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_WT-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
Ritscher-Schinzel syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
496100371_TCx_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.17342
XPNPEP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2206
R121919	DeepCoverMOA Drug Mechanisms of Action	1.0	0.33
Polar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.891
MCF7_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135612
GSE162739_4_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A84695402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31709
A549_Danusertib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111414
PMC8803621-mmc5.xlsx-54JIB-04genes_w_GATA4_motif-GATA4_Q3_GATA4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE122509,GSE122513_2_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Flavopiridol HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202009
ALK	Kinase Library Tyrosine Kinome Atlas	1.0	99.69
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212916
Cranioectodermal dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.358
GSE193258,GSE193259_9_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12502
bilateral cleft palate	MGI Mouse Phenotype Associations 2023	1.0	null
FLT3	Kinase Library Tyrosine Kinome Atlas	1.0	96.3
GSE98964_1_v_4_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K00697836	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22933
A549_Roxadustat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0224168
MCF7_Entacapone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219231
Septum pellucidum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.384
BRD-K15591233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22296
CRCGN014_HEPG2_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28329
Ciliary transition zone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.444
BRD-K17895004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00332
Promyelocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.104
GSE186647,GSE217288_11_v_4_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5319
Epiglottis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.271
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Inner medullary collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.795
Embryonic brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCF7_AMG-900_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128578
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Ofloxacin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0275332
GSE100863,GSE100864_3_v_1_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K80232129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46895
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE150895,GSE150896_0_v_1_kif15_human	RummaGEO Gene Perturbation Signatures	-1.0	null
mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
Ovary	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
abnormal sternum morphology	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K78965436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81493
BRD-K36909552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09091
GSE253089_0_v_1_ephb2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K70145120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13309
ERF::NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.3996
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ACYP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46046
GSE42805,GSE42811_2_v_3_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_MK-0752_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017339
Ciliary plasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.857
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.368
MCF7_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015573
PMC10353540-Table_1.xlsx-HCC1954_AR_vs_HCC1954_A-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160373_6_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K97869597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63557
WDR5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24509
BRD-K53308623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60748
BRD-K83438939	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1648
Chromosome 1q21.1 duplication syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
A549_M344_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146274
BRD-K57821544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20408
Hirschsprung's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.347
atrioventricular septal defect	MGI Mouse Phenotype Associations 2023	1.0	null
ADRA2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34595
BRD-K37507671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17106
BRD-K88292241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31836
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table4_gnomAD_EAS_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
496100622_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.98103
GSE210101,GSE210114_7_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03591
UMUC7	DepMap CRISPR Gene Dependency	1.0	9.25954
A549_Tazemetostat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.013947
BRD-A30758703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34762
BRD-K62193937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14869
Astrocytoma	ClinVar Gene-Phenotype Associations 2025	1.0	null
A549_Decitabine_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137714
GSE249098_1_v_2_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mubritinib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.63
BRD-K37961770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18802
GSE238018_3_v_2_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Resveratrol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149362
UBE2D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71303
BRD-K97805186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02653
GSE152441,GSE152442_6_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
APEX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00025
GSE88819_6_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Oligohydramnios	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.327
BRD-K93737936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11451
Nephronophthisis 12	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.643
GSE202310_1_v_0_ube3d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30565
GSE82032_3_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8481886-Table_1.xlsx-A_subsets-iMSC_UC_MSC_bone_marrow_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K99824630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37387
abnormal turbinate morphology	MGI Mouse Phenotype Associations 2023	1.0	null
GSE181003_1_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_SNS-314 Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0118407
CRCGN010_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.52489
Extensor digitorum communis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.617
A549_Tazemetostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183862
BRD-K85919350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56528
BRD-K67998155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03801
GSE218814_1_v_0_suv39h1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hic1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.4842
CYBRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13291
GSE153871_4_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_AR-42_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0282045
BRD-K52492854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21697
SSR 69071	DeepCoverMOA Drug Mechanisms of Action	1.0	1.26
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220809
ED-71-GA72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233426
PHOX2B-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3413
GSE162739_2_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE68156_0_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SB-222200	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.72
CRCGN011_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5563
GSE218060_2_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Spinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
Middle ear	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.857
Migalastat	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.43
BRD-K87669982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43046
ZFP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60838
UA-39-TN76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251615
GSE69869_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K80359388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43366
MCF7_Patupilone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141367
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8445
Peritubular contractile cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.598
GSE239844_1_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.171
GSE239541_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Selisistat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199961
A549_AR-42_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144987
A549_G007-LK_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0234927
BRD-K08658757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49897
BRD-K82814367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45998
GSE95302_1_v_4_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null