association	dataset	threshold value	standardized value
IPO13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07151
NUDT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2198
2,2'-Biquinoline	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
FOXA1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20507
Other source	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.2
GSE157262,GSE157268_3_v_0_ythdc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bach1::Mafk	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.2895
GSE115542_2_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.656
6794_PRPF38A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.798037
DCTN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03092
AU565	DepMap CRISPR Gene Dependency	1.0	2.29715
EN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.1633
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D1_1084_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	1.0	null
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.4372
GSK2636771	DeepCoverMOA Drug Mechanisms of Action	1.0	0.29
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.504755
GSE242083,GSE242098_3_v_4_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153484_2_v_0_foxp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
B-lymphoblastoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.61
GSE165307_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HOXD12::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3165
496100395_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.84289
MEF2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1746
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_ENMD-2076 L-Tartaric acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133124
GSE220914_2_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210101,GSE210114_2_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Foxo1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.1412
SNU61	DepMap CRISPR Gene Dependency	1.0	2.40175
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE126345_11_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE207787_3_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11073998-41375_2024_2235_MOESM9_ESM.xlsx-THP1_phosphoproteome-Unnamed_2_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
WBP1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33004
GSE112763,GSE112767_4_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RNASE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4246
preweaning lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
TTLL13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10335
GSE213588_9_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12381255-41389_2025_576_MOESM3_ESM.xlsx-Differentiated_SRCAP-1879-Gene_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
NOL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29887
GSE239844_11_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
E2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.6058
GSE202744_1_v_0_toyocamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
D502MG	DepMap CRISPR Gene Dependency	1.0	2.23489
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4908_MCOLN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.05497
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216352,GSE216354_1_v_0_keap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF540	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84563
HUNS1	DepMap CRISPR Gene Dependency	1.0	3.11921
T-cell chronic lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Erythroleukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.656
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.405232
GSE234289_4_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE196343_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE118816_0_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291165
GSE178714_5_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
nucleus	GO Cellular Component Annotations 2025	1.0	null
SNUC1	DepMap CRISPR Gene Dependency	1.0	3.11981
GSE210101,GSE210114_11_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
INAVA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20875
GSE114553_0_v_1_lhx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
SNU410	DepMap CRISPR Gene Dependency	1.0	2.42854
P2RX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11139
GSE126345_4_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233049_1_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC2263127-pone.0001816.s001.xls-E2F3_down_Bild-Symbol_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
CAY10650	DeepCoverMOA Drug Mechanisms of Action	1.0	0.22
MMP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06086
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.105
NB10	DepMap CRISPR Gene Dependency	1.0	2.48651
GSE140651,GSE140653_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Venom apparatus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.317
7251_RFFL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.688521
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
859_BMS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.509734
U343	DepMap CRISPR Gene Dependency	1.0	2.22629
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXD4L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51296
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE99875_2_v_0_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.470153
guanyl-nucleotide exchange factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.384
AMO1	DepMap CRISPR Gene Dependency	1.0	2.19922
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9997
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1114
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE219195_4_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HES5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9886
NALM-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.61
4371_KIAA1958_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.59316
MM370	DepMap CRISPR Gene Dependency	1.0	2.17479
GSE180525,GSE180528_1_v_0_tbx3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Epilepsy	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.131
GNPTAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01557
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE136622_6_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RRP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72231
GSE154577_7_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244691
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.876812
preweaning lethality, complete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
PMC5640240-ppat.1006668.s013.xlsx-BETA4-379_common_elements_in_shEP400-1_BETA_shEP400-3_BETA_shMYCL_BETA_and_shEP400-2_BETA_BHLHE23	Rummagene Transcription Factor Associations 2026	1.0	null
GSE102757_1_v_0_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_MC1568_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137319
OVMANA	DepMap CRISPR Gene Dependency	1.0	2.13884
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5855
GSE239844_7_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE115542_5_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CCDC90B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27901
GSE213588_9_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder	GTEx Tissue Gene Expression Profiles 2023	1.0	3.32358
LHX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00549
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259228
HIF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9867
KPL1	DepMap CRISPR Gene Dependency	1.0	2.02908
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC3607232-mmc3.xlsx-b_RUNX1_SEM_MLLC_H3K4Me3-x_2_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.671754
YD8	DepMap CRISPR Gene Dependency	1.0	2.01406
ZNF654	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12302
MOLT-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.789
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25633
GSE174383_2_v_7_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FOXD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.1979
GSE71468,GSE76476_0_v_1_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-USF2_USF2	Rummagene Transcription Factor Associations 2026	1.0	null
ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7298
HuH-7-Lunet cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.746
GSE120612_7_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9288051-13046_2022_2428_MOESM6_ESM.xlsx-Super_enhancers_in_B-ALL3-OVERLAP_GENES_PAX5	Rummagene Transcription Factor Associations 2026	1.0	null
FECH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10394
TPX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01048
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.619
ITSN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23473
SUCLG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85413
GSE139948_3_v_6_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.0367
GSE220097_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239844_7_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226770_1_v_6_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE87412,GSE92423_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE207282_1_v_0_polydatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE114883_0_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0345
Blood group incompatibility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
GSE58724_3_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE139966_4_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cell type cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.656
PMC6683136-41598_2019_47363_MOESM2_ESM.xlsx-GENE_SET-Positive_correlation_of_ZEB1-AS1_and_other_genes_ZEB1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120595_5_v_1_arid2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30585
GSE173873_10_v_11_stra8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120595_5_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE81803,GSE81912_4_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Central nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.131
RPS20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.58088
GSE123943_2_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.656
graft-versus-host disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.413
GSE203329_0_v_3_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160001,GSE160670_3_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.301912
MDAMB415	DepMap CRISPR Gene Dependency	1.0	2.56189
Late endosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.352
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
MEF2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.9316
PMC3728595-srep02327-s1.pdf-17-POU2F2_POU2F2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169152_5_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Atrial fibrillation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.973
8856_TFR2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.590327
GSE200673,GSE200691_2_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0879
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229568
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.131
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE159893_2_v_1_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
DBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9838
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
Heart disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.973
Pluteus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.831
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.5087
GSE70883,GSE71179_0_v_1_pbx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE102467_1_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
MSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.4335
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.471516
CHPF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35225
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3302
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.294131
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE166920_6_v_2_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294027
RUNX1-27514584-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Mafb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.5479
496100485_PCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.31888
CCDC163	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28509
GSE210101,GSE210114_7_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
COLO201	DepMap CRISPR Gene Dependency	1.0	2.03135
GSE196259_2_v_3_gcm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
chr16_1694735_G_A_b38	GTEx eQTL 2025	1.0	1.38526
KIF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06307
GSE158834_2_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.5158
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100460_TCx_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.60435
PAAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06386
GSE213228_4_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Autosomal recessive spinocerebellar ataxia 8	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.173
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Thygro-r__CIC-1n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.2769
Huperzine A	DeepCoverMOA Drug Mechanisms of Action	1.0	0.37
MSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6628
increased bone mineral content	IMPC Knockout Mouse Phenotypes	1.0	null
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.419509
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249286
GSE217694_4_v_0_pold1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE159446,GSE159449_1_v_0_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE214931_4_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EFNA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23875
Autosomal dominant nonsyndromic deafness 40	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.579
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.0795
Blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.2
GSE181003_3_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223908,GSE223909_1_v_6_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
6834_PSAT1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.519803
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.332686
MCF7_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153264
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.5047
GSE169152_3_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210101,GSE210114_5_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brain disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.131
GSE135030_11_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kleefstra syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.243
Cardiovascular system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.973
GSE161170,GSE161268_1_v_3_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXA1-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160373_6_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100324_FWM_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.20448
chr16_1641280_C_A_b38	GTEx eQTL 2025	1.0	1.05163
GSE228181_0_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.253358
GSE214823,GSE214824_6_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZSCAN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16364
ANKS1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24616
B4GALT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16274
GSE103122_0_v_1_riok3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
chr16_1681305_G_T_b38	GTEx eQTL 2025	1.0	1.25516
PMC12486367-Supplementary_Data2.pdf-291-ZNF184_ZNF184	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211226_1_v_0_sirpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RAD21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90501
GSE123943_4_v_3_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE136622_2_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135400_1_v_0_kdm1b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9013128-NIHMS1795992-supplement-6.xlsx-ARID2_MUT_Dowregulated-Gene_name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
496100628_FWM_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00131
YK-4-279	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.04
GALT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34341
TLX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2022
SMG8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32952
SW626	DepMap CRISPR Gene Dependency	1.0	3.02972
GSE126127_0_v_1_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.663325
GSE217776,GSE217829_2_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286443
BD-04-NG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203881
P31FUJ	DepMap CRISPR Gene Dependency	1.0	2.10962
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209531
ACOT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13091
TT1TKB	DepMap CRISPR Gene Dependency	1.0	2.58712
GSE150669_0_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12769604-13402_2025_1147_MOESM6_ESM.xlsx-Table_S4_3_Venn-Tumor_AND_Prognosis_NOT_Scissor_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112860_5_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5216
GSE158834_2_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Abiraterone acetate_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00763043
decreased prepulse inhibition	MGI Mouse Phenotype Associations 2023	1.0	null
KATOIII	DepMap CRISPR Gene Dependency	1.0	2.93692
GSE230329_0_v_3_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PLCG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11083
GSE239844_11_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SMPD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03266
GSE195663_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148252_2_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE71468,GSE76476_0_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211948
GSE114883_1_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8858874-NIHMS1764275-supplement-Supplemental_Table_2.xlsx-R1_SOX2_bound_genes_5000bp_6-9--Nearest_Ensembl_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney - Medulla	GTEx Tissue Gene Expression Profiles 2023	1.0	3.52924
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
AA-58-FJ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202253
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Parallel fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.012
GSE120612_7_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MROH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31948
GSE171175,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200065
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE207514,GSE207515_0_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SOHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9782
NCIH1437	DepMap CRISPR Gene Dependency	1.0	2.49263
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-circARID1A_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8901773-41598_2022_7986_MOESM3_ESM.xls-T_vs_LPS-Gene_symbol_ENSEMBL_ID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Posterior amygdala	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.732
GSE68156_3_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MYH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35549
WDR5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07382
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0703
GSE147613_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
WC-59-RG09_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207648
RIOK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78931
4532_LCLAT1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.528807
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311385
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9406
GSE165307_3_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.7373
MCF7_Trametinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00858885
Hematopoietic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.2
UNCX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.2945
SKNDZ	DepMap CRISPR Gene Dependency	1.0	3.22302
EXD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42418
GSE152432_6_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Griscelli syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
GSE114992,GSE114993_7_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE112860_3_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE240896,GSE240899_2_v_4_ccnt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE204929_0_v_1_ywhag_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	157.37
MCF7_S3I-201_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154835
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.656
CHLA266	DepMap CRISPR Gene Dependency	1.0	2.38997
NUDT21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15762
9420_TUBB_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.520405
GSE94814_2_v_3_reck_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100393_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.56167
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.406
CCLP1	DepMap CRISPR Gene Dependency	1.0	2.54408
GSE232218_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Chronic lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BMF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00256
HCC1428	DepMap CRISPR Gene Dependency	1.0	2.66486
ALX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.3455
PMC6172843-13059_2018_1523_MOESM6_ESM.xls-Sheet1-Table_S5_mRNAs_variation_abundance_1_5-fold_in_YBX1-knockdown_BGC-823_cells_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
IRF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.8261
CHLA15	DepMap CRISPR Gene Dependency	1.0	3.15185
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE211128_4_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OCIMY7	DepMap CRISPR Gene Dependency	1.0	3.4413
Male reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.656
NALM16	DepMap CRISPR Gene Dependency	1.0	2.19184
MRPL20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11321
SCCOHT1	DepMap CRISPR Gene Dependency	1.0	2.41002
GSE229344_2_v_0_cyb5r3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Histone locus body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.326
SKMEL19	DepMap CRISPR Gene Dependency	1.0	3.02653
GSE146982_0_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE60367_2_v_1_cxcr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112995,GSE132079_1_v_3_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Organelle lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.532
BD-96-HO33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.369643
Respiratory chain complex I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.837
CAL78	DepMap CRISPR Gene Dependency	1.0	2.22372
Bone marrow cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE190316,GSE190324_1_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
ADNP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1329
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.54412
496100463_FWM_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.1225
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_prom_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10149505-41392_2023_1393_MOESM2_ESM.xlsx-CPCMR-Hugo_Symbol_MEIS2	Rummagene Transcription Factor Associations 2026	1.0	null
Mouth floor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.518
ZIC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.302
GSE169713,GSE169715_1_v_2_tert_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_2_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216446
TCF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35966
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE249893_1_v_0_tfam_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126127_5_v_3_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
3570_GTF2E2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.516411
GSE110440_1_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9288051-13046_2022_2428_MOESM6_ESM.xlsx-Super_enhancers_in_B-ALL3-CLOSEST_GENE_PAX5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210101,GSE210114_2_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Venom gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.336
5762_NPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.510091
PRRX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.035
GSE214823,GSE214824_6_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Epilepsy and lamotrigine-induced maculopapular eruptions	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.952288
SGTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28798
GSE191105_2_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RD	DepMap CRISPR Gene Dependency	1.0	2.67156
GSE111247_2_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSU	DepMap CRISPR Gene Dependency	1.0	2.55779
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.22721
GSE114992,GSE114993_7_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF766	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0263
Doramapimod	DeepCoverMOA Drug Mechanisms of Action	1.0	0.34
Peripheral blood stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.929
HAUS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19484
GSE193588_1_v_0_pax3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HEC116	DepMap CRISPR Gene Dependency	1.0	2.21484
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE58724_1_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE240027,GSE240030_1_v_4_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-Unnamed_4_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
ETV3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1701
JVM3	DepMap CRISPR Gene Dependency	1.0	2.8195
AR-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
5483_NBPF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.653649
HOXB9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4509
GSE223287,GSE223290_2_v_4_braf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE179002_4_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RCHACV	DepMap CRISPR Gene Dependency	1.0	2.32905
PMC9745835-supp_079195.122_Supplemental_Table_1.xlsx-ADAR-KD-Gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
ETV2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2524
ETV5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5824
GSE112763,GSE112767_4_v_5_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.2
TAF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30628
GSE174383_2_v_0_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NB69	DepMap CRISPR Gene Dependency	1.0	2.75041
496100418_TCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.47396
PMC12019345-41598_2025_98989_MOESM10_ESM.xlsx-Sheet_1-CCNE2_related_genes_AND_HNSCC_HNSCC_DDP_NOT_DDR_Genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
FEV	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8516
496100402_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.0279
MPHOSPH10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02275
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE101112_0_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AP5M1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45778
GSE98964_1_v_4_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100306_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.10023
GSE126345_9_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNU81	DepMap CRISPR Gene Dependency	1.0	2.15852
SW837	DepMap CRISPR Gene Dependency	1.0	2.50773
GSE128333_3_v_5_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214479
Hic1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.7044
MCF7_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017101
GSE188869,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PKNOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2361
GSE129241_4_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11603793-12964_2024_1953_MOESM1_ESM.pdf-54-ZNF75D_ZNF75D	Rummagene Transcription Factor Associations 2026	1.0	null
P2URK562	DepMap CRISPR Gene Dependency	1.0	2.89929
GSE239844_6_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CDX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02275
GSE87404,GSE87812_2_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SKNO1	DepMap CRISPR Gene Dependency	1.0	2.86315
GSE198794_2_v_1_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10061014-Table5.XLSX-C_vs_L-Table_S5a_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE165647_2_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174383_2_v_5_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_6_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PROX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6782
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SSTR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18689
GSE224877_2_v_1_pctp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PPP5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41554
LB1047RCC	DepMap CRISPR Gene Dependency	1.0	2.39102
TTC549	DepMap CRISPR Gene Dependency	1.0	2.01727
6870_PSMD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.58711
GSE142232,GSE142234_0_v_3_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lymphoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.2
MYLA	DepMap CRISPR Gene Dependency	1.0	2.27317
OCILY18	DepMap CRISPR Gene Dependency	1.0	3.41068
abnormal embryo size	IMPC Knockout Mouse Phenotypes	1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.3526
Integumentary system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.131
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	88.0291
MDAMB453	DepMap CRISPR Gene Dependency	1.0	2.40929
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	86.4411
membrane-enclosed lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.532
cleft palate	MGI Mouse Phenotype Associations 2023	1.0	null
PMC6347838-13046_2019_1042_MOESM3_ESM.xls-PRDM16_group_peak_anno-Gene_PRDM16	Rummagene Transcription Factor Associations 2026	1.0	null
ARHGAP23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1513
GSE178714_5_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
APP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63123
GSE157282_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF682	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.4896
PMC8791942-41398_2021_1766_MOESM7_ESM.xlsx-LPS_DEGs_Heatmap-GeneID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234495
Ebf4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.3282
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Foxo3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.4143
BICD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94387
Migalastat	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
Stevens-Johnson syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.034
PMC10901781-41467_2024_46134_MOESM12_ESM.xlsx-Supplementary_Data_9-Supplementary_Data_09_Differential_expressed_genes_in_RUNX1-mutated_AML_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
MAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37703
KH-CB19	DeepCoverMOA Drug Mechanisms of Action	1.0	0.49
GSE87412,GSE92423_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153867_6_v_8_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DKKL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40502
GSE77108_0_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UTP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90841
SNU668	DepMap CRISPR Gene Dependency	1.0	2.54677
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE104022_3_v_4_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE114883_0_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE172490_5_v_3_junb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190235_1_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.821494
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204852
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
Nuclear lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.532
PMC8901773-41598_2022_7986_MOESM3_ESM.xls-PIO_vs_LPS-Gene_symbol_ENSEMBL_ID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239844_6_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210101,GSE210114_5_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5263239-mmc2.xls-MV4_11_-_MLL-AF4-Non-spreading_targets_gene_names_1985_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.9828
ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4898
ZBTB12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4055
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ZUP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12214
Nfe2l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.5372
JB-75-NC66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270651
IPO7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95498
TIRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11125
GSE140997_4_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_body_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
SNU5	DepMap CRISPR Gene Dependency	1.0	2.28435
GSE226316_6_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH747	DepMap CRISPR Gene Dependency	1.0	2.36445
PMC8387919-mmc2.xlsx-ST9_NEUROG3_bound_TF_genes-Supplemental_Table_9_NEUROG3_bound_TFs_genes_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
L363	DepMap CRISPR Gene Dependency	1.0	3.16314
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	84.0464
GSE210101,GSE210114_7_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146982_4_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE172146_2_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Linifanib_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143458
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D3_2440_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7848
MFE319	DepMap CRISPR Gene Dependency	1.0	3.02406
BORC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.525
6460_PLRG1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.830733
Stat6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.8564
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	77.843
TOX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22039
496100326_TCx_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.01408
GSE233049_2_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal embryo size	MGI Mouse Phenotype Associations 2023	1.0	null
496100478_HIP_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.34858
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
6550_POLR2I_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.531705
ZSCAN31	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8745
Large granular lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.2
GSE158834_2_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114992,GSE114993_7_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RCM1	DepMap CRISPR Gene Dependency	1.0	2.84436
AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.656
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21982
MAPACHS77	DepMap CRISPR Gene Dependency	1.0	2.01647
beta-thalassemia major	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0175
Ethiprole	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
IRF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.1667
SNU620	DepMap CRISPR Gene Dependency	1.0	2.60538
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111247_2_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4905481-oncotarget-07-11397-s002.xlsx-Pinin_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195713_0_v_1_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Purine nucleoside phosphorylase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.054
SCML1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.107
PMC9336541-Table_3.XLSX-C-vs-H6-L_filter_annot-Unnamed_18_HMX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE165647_5_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SCAR complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.882
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E20-D3_1775_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_10_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE103068_5_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.903698
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-Embryo-Hatchling_1272_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241729
GSE219274,GSE219276_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE155852_0_v_2_apigenin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
2792_EXOSC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.526226
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110178_1_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5832
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ragulator complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.386
GSE196104,GSE196106_2_v_0_vsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-NFE2L1_NFE2L1	Rummagene Transcription Factor Associations 2026	1.0	null
KMS27	DepMap CRISPR Gene Dependency	1.0	3.42216
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.526043
GSE95077_1_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE166920_6_v_1_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216193
GSE164874_5_v_12_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KIAA0040	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16641
GSE131649_4_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.656
IRF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8311
Tbx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.3978
GSE225901_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_2_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213228_4_v_3_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LRRC58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50706
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.42662
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.4258
GSE235390_4_v_2_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXC9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.055
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	253.115
KIF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10183
GARRE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38226
GSE225735_1_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE185519_4_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE228181_3_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120595_0_v_1_arid2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE138001_5_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LY2801653	DeepCoverMOA Drug Mechanisms of Action	1.0	0.46
GSE242290_1_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE240027,GSE240030_5_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193351_1_v_2_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Natural killer cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.2
Male reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.656
PSMG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08375
ZNF257	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.9834
PMC9038526-mmc1.xlsx-postCOVID_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
HCC56	DepMap CRISPR Gene Dependency	1.0	3.15618
HEY1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9581
Adult T-cell lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.685
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.2749
WM1799	DepMap CRISPR Gene Dependency	1.0	2.06846
increased bone mineral content	MGI Mouse Phenotype Associations 2023	1.0	null
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
D458	DepMap CRISPR Gene Dependency	1.0	3.38529
TTC30B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3245
ZIC5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.1815
Foxl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.4826
ZSCAN21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9102
GSE130956_0_v_1_icaritin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE173307,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE253056_0_v_1_erythropoietin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114883_1_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE80537_5_v_2_adhfe1_human	RummaGEO Gene Perturbation Signatures	1.0	null
JURKAT	DepMap CRISPR Gene Dependency	1.0	2.77369
TBX2-35687133-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
FOXO1::ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8956
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.424057
Ammonium transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.907
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
GSE213650_3_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8791942-41398_2021_1766_MOESM7_ESM.xlsx-LPS_DEGs_Heatmap-hgnc_symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3245
GSE136622_0_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.174
496100397_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.43274
GSE215086_8_v_0_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.23086
4149_INTS4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.624234
RGFP966	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.46
GSE145915_3_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE191015_0_v_2_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE171311_0_v_1_ellagic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXA1-26457646-LHSAR-HUMAN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
CREB3L4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2426
PMC10061014-Table5.XLSX-C_vs_LD-Table_S5c_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_DEX_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Parecoxib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.41
ERF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0081
GSE128563_2_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146982_4_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.131
B-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.133
6548_POLR2G_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.597072
GSE179880_10_v_3_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256049
CREM	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0552
HLA-B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03091
CEBPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.565
GSE106661,GSE106665_2_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE161846,GSE161849_3_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXA1-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE139975_3_v_1_rnf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE196540,GSE196542_2_v_0_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ALG11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0804
JF-39-BZ76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220067
abnormal bone structure	MGI Mouse Phenotype Associations 2023	1.0	null
EMX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3951
ETS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2198
JR	DepMap CRISPR Gene Dependency	1.0	3.13332
GSE157594_6_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE129725_1_v_5_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ISX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7653
GSE149901_3_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8858874-NIHMS1764275-supplement-Supplemental_Table_2.xlsx-R1_SOX2_bound_genes_5000bp_6-9--Gene_Name_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112860_5_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
496100538_HIP_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.15432
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7204
KARPAS-299 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.55
COV434	DepMap CRISPR Gene Dependency	1.0	2.17258
GSE217071_1_v_2_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242290_1_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Hyphal tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.569
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217692
GSE111247_2_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE196104,GSE196106_3_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VCAP	DepMap CRISPR Gene Dependency	1.0	2.94318
E2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.4621
SCMCRM2	DepMap CRISPR Gene Dependency	1.0	2.9926
haptoglobin-hemoglobin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.653
Leukocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.2
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.281099
LBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.1552
Meiotic prophase fetal germ cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE71468,GSE76476_2_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11933697-41467_2025_58216_MOESM9_ESM.xlsx-SD7_C_R_NS1_Med_ATF3_DEG-symbol_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
NB1643	DepMap CRISPR Gene Dependency	1.0	2.73114
Heart conduction disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.973
6549_POLR2H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.606061
GSE103068_0_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0625
GSE58724_1_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195663_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
XPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0283
GSE189683_3_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.64634
PAX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24664
GSE146982_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE209973_1_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE161170,GSE161268_0_v_2_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ESR1-26153859-T47D-HUMAN-BREAST-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
8888_THOC2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.516145
DAGLB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12507
Prostate carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.656
RAB5IF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26291
GSE168797_1_v_6_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	91.0021
GSE223908,GSE223909_1_v_3_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_JNJ-26854165_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119068
ARNT::HIF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.2212
hr5	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.793
PMC11933697-41467_2025_58216_MOESM8_ESM.xlsx-SD6_ATF3_EV_NS1-SYMBOL_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SKIL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36261
GSE166920_6_v_4_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
Gastrula	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.945
GSE239844_7_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BTBD17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20419
BCAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50679
SKMM2	DepMap CRISPR Gene Dependency	1.0	2.80798
GSE120595_0_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EPLC272H	DepMap CRISPR Gene Dependency	1.0	2.19864
YIPF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45955
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE186483_2_v_4_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110497
OCUM1	DepMap CRISPR Gene Dependency	1.0	3.06113
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233233
L2HGDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18293
GSE151782_2_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.500677
GSE109140_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE101546_2_v_4_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227592_13_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FL cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.616
PMC9634663-DataSheet10.xlsx-K562-MYC-AID_RNA-Seq_1326_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
HDAC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62977
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE196540,GSE196542_4_v_0_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130956_2_v_1_icaritin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE154577_7_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ESR1-30970003-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE199092_3_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH3122	DepMap CRISPR Gene Dependency	1.0	2.0775
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D1_1591_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE60691_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
nucleus	GO Cellular Component Annotations 2023	1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.131
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
WDR55	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4211
GSE171177,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-CCRF-CEM_EV_vs_ectopic_TET2_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE173873_10_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Alpha thalassemia-intellectual disability syndrome type 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.303
5462_NAPA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.884668
Acute chest syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-GATA6_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
DHX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5117
TATDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20814
DLX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.8658
cleft palate	IMPC Knockout Mouse Phenotypes	1.0	null
PMC10274745-media-4.xlsx-S3B-Table_S3_Reanalysis_of_publicly_available_data_to_identify_AR_and_ER_direct_target_genes_related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.16741
GSE123943_1_v_3_sox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ezatiostat	DeepCoverMOA Drug Mechanisms of Action	1.0	0.2
GSE147613_1_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246888
PF-04418948	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.26
GSE137914_0_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal bone structure	IMPC Knockout Mouse Phenotypes	1.0	null
HS766T	DepMap CRISPR Gene Dependency	1.0	3.06771
GSE231648_4_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2755
GSE149355_0_v_1_esrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LIN37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17194
MIXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.2643
GSE112174_5_v_7_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5557398-13045_2017_515_MOESM1_ESM.xlsx-S8-DUX4_SpecDMCs-Unnamed_3_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE101767_1_v_0_wdr11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
E2F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2393
496100390_PCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.20109
RHJT	DepMap CRISPR Gene Dependency	1.0	2.76149
GSE148510_1_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112860_5_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247417
PMC3889689-elife01439s001.xls-RFX2_rnaseq_chip_DirectDE_final-ENSG_ID_RFX2	Rummagene Transcription Factor Associations 2026	1.0	null
TBXT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2612
3343_GFI1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.586927
GSE226285_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.461719
WDR6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68445
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_U87MG_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE172146_2_v_1_mettl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.656
Nrf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	52.1517
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1915
GSE126345_0_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNU1196	DepMap CRISPR Gene Dependency	1.0	3.02944
HuH-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.773
GSE169152_5_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10824666-43018_2023_699_MOESM2_ESM.xls-Suppl_Table_S4-AM-1882_AUC_vs_Gene_Expression_PRISM_Breast_and_Ovarian_Cancer_Cell_lines_n_58_1_PRDM6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169155_5_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE58724_3_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204852
GSE187006_3_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.407589
GSE171175,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE154253_1_v_0_tnfaip8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nucleolus	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.532
GSE71468,GSE76476_2_v_1_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOXE1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	152.232
IGDCC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06064
PMC3889689-elife01439s001.xls-RFX2_rnaseq_chip_DirectDE_final-GeneName_RFX2	Rummagene Transcription Factor Associations 2026	1.0	null
decreased prepulse inhibition	IMPC Knockout Mouse Phenotypes	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
LCL161	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
GSE195513_0_v_3_cpeb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE109140_2_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
5447_NADSYN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.10033
ZNF417	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.2312
PSMC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2556
GSE217132_0_v_1_pfkfb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BC-54-ON71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24927
GSE214823,GSE214824_0_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormal placenta size	IMPC Knockout Mouse Phenotypes	1.0	null
GSE186707_1_v_0_hdac4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE129293_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	17.9563
GSE182770,GSE182784_0_v_1_chd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3470785-NIHMS377161-supplement-3.pdf-620-TIGD6_TIGD6	Rummagene Transcription Factor Associations 2026	1.0	null
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NCIH2286	DepMap CRISPR Gene Dependency	1.0	2.81938
GSE185519_3_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.656
SCHNEIDER-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.534
7178_RBM48_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.668031
CLK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22667
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
C19orf44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13757
GSE173873_10_v_6_stra8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE215351,GSE215794_4_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100355_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.30354
Skin disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.131
EPAS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1859
FOXA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06377
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE224969,GSE224971_0_v_7_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AMZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39833
4540_LDB1_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.634126
GSE126345_7_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE247764_4_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HES7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6967
A388	DepMap CRISPR Gene Dependency	1.0	2.28044
7141_RBBP5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.768029
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224556
NUP93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31976
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
Sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.138
496100335_PCx_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40247
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_U87MG_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
FARAGE	DepMap CRISPR Gene Dependency	1.0	2.26109
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.5345
ZNF574	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.8721
PMC10879698-mmc1.pdf-12-MTF2_MTF2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE108675_3_v_0_slc1a4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
8500_STAT6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.622943
GSE130676_0_v_2_suds3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211177,GSE211178_9_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE80098,GSE80366_0_v_5_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DIS3L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23504
GSE191105_2_v_4_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE93124_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HES2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.576
abnormal placenta size	MGI Mouse Phenotype Associations 2023	1.0	null
GSE193588_3_v_2_pax3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12021535-CPH4-15-e70011-s001.xlsx-S21-KLF2_KLF2	Rummagene Transcription Factor Associations 2026	1.0	null
PLIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27056
PMC10646502-Table_1.xlsx-Table_S8-IRF3_Target_genes_according_to_Dorothea_s_TF-TG_network_confidence_A_to_C_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
SA-32-CC58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.344155
496100407_FWM_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.23413
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	101.895
6851_PSMB3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.544396
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE123943_4_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
3776_HIST1H4A_ENST00000359907.3	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.654758
GSE168602,GSE168604_2_v_6_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE206729_2_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE159148_0_v_1_sdc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SLC15A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39568
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222712
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.359304
496100338_HIP_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.22835
GSE169152_3_v_1_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DMAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0347
GSE211963_0_v_3_cd200_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562	DepMap CRISPR Gene Dependency	1.0	3.21545
GSE193351_1_v_0_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
Ciliated cell_Lung_Human	CellMarker Gene-Cell Type Associations	1.0	null
Null cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.2
GSE203267_0_v_1_alkbh5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Siphon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.551
GSE247764_5_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125782_3_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NANOS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13158
PMC5640240-ppat.1006668.s013.xlsx-MAX_ChIP_shEP400-1-Unnamed_6_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
HEPG2	DepMap CRISPR Gene Dependency	1.0	2.9246
6549_POLR2H_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.594056
GSE153258_1_v_0_dcp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9218734-Supplementary_Data3.xlsx-KRIEG-KRIEG_HYPOXIA_NOT_VIA_KDM3A_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE204784,GSE204787_1_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.304582
IQSEC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54065
Intracellular organelle lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.532
PMC8709578-elife-69843-supp4.xlsx-HSF1_ChIP-seq_peaks-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE153757,GSE153758_1_v_3_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TOR1AIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00244
Stat5a::Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.2457
GSE239541_8_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.5807
GSE153867_6_v_3_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE246335_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MM253	DepMap CRISPR Gene Dependency	1.0	3.04826
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4047
RPLP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24216