association dataset threshold value standardized value BRD-K03935681 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00127 CRCGN015_HEPG2_48H:G05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.00975 CEP290 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03905 OVKATE CCLE Cell Line Gene CNV Profiles 1.0 1.71348 Brain Lower Grade Glioma_LGG_TCGA-DB-A4XC-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAP3K11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.94336 DOT1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6464 CRCGN015_HEPG2_48H:F16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.74275 SNU-182 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.919616 BRD-K64345025 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35626 BRD-K97339945 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54862 SHORT syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.021 IX Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.18659 CRCGN017_MCF10A.WT.HP_24H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5298 PEO4 DepMap CRISPR Gene Dependency 1.0 2.356 C4orf3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61582 H3K27me3_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_HEPG2_48H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.08621 SG in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08871 T98G Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.903008 NCIN87 CCLE Cell Line Gene Expression Profiles -1.0 -1.95817 Perturb_14796_OE_Mycn_SRP094656 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.3621 PRORP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84699 molecular_function GO Molecular Function Annotations 2015 1.0 null COX15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07343 DCAF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76784 KPNA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10501 CRCGN008_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.6265 SCC4 CCLE Cell Line Gene CNV Profiles -1.0 -1.44367 CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.66018 HOXD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52224 BRD-K52854560 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02789 BRD-K33283629 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.79372 RPN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69344 gap junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.519798 FOXF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.6785 RHBDF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58372 BRD-K13257316 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.88807 RAX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.52244 CTCF_epithelial cell of esophagus_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POGLUT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80085 Liver hepatocellular carcinoma_LIHC_TCGA-ED-A8O6-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBX19 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.6105 ZNF275 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89632 PANC 02.03 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.835114 BRD-K26063034 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28729 Pituitary GTEx Tissue Gene Expression Profiles 2023 1.0 1.57296 KARPAS1718 DepMap CRISPR Gene Dependency 1.0 2.97442 NFIC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.2402 eye and adnexa disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.688692 BRD-K71538933 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.92513 CRCGN015_HEPG2_48H:P04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.82022 BRD-K63270352 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13246 BRD-K92440102 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21791 SKA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10409 HOXC9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.0059 CA12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9781 NR2F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.4528 CRCGN017_MCF10A.WT.HP_24H:N16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.72305 CRCGN014_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.61765 hippocampus (hippocampal formation)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.02734 MGAT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36072 RUNX1-27457419-CHIP-SEQ-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K21579116 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.05668 LENG9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37492 ACOT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24433 TFAP4::ETV1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.3038 NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20667 cervical cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.10363 MM1S DepMap CRISPR Gene Dependency 1.0 2.33012 NFATC2 JASPAR Predicted Transcription Factor Targets 1.0 null ZNF274 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.2368 TLE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09725 Eye disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.07 CRCGN008_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.04955 PCGF2-27294783-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null IDO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67982 ZNF322 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42377 CRCGN017_MCF10A.TP53.M_24H:N16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.01285 BAZ2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16259 MEF2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.7085 Becker GDSC Cell Line Gene Expression Profiles -1.0 -1.64125 BRD-K74482064 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5016 OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.64397 SERINC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36153 PDLIM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11498 SOX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5679 abnormal eye morphology MPO Gene-Phenotype Associations 1.0 null CRCGN014_HEPG2_3H:M21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.58755 UBN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69922 ESPNL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42107 PSS008 DepMap CRISPR Gene Dependency 1.0 2.95832 ZNF668 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85367 RBMX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40668 snps GeneRIF Biological Term Annotations 1.0 null ZNF616 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3066 Lung squamous cell carcinoma_LUSC_TCGA-66-2791-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K97962579 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55594 pineal body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.71651 visual perception GO Biological Process Annotations 2015 1.0 null PITHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35526 CRCGN015_HEPG2_48H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.5197 Nervous system cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.29 VPS37C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42515 LU-65 GDSC Cell Line Gene Expression Profiles 1.0 1.4408 interpositus (intermediate) nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.993916 SKNO1 CCLE Cell Line Gene CNV Profiles -1.0 -1.83135 BRD-K41287744 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00127 KP-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null EBF1-22473956-BONE-MARROW-MOUSE ChEA Transcription Factor Targets 2022 1.0 null 496100377_PCx_no dementia_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.09193 NCIH226 CCLE Cell Line Gene CNV Profiles -1.0 -1.91773 SMARCE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40559 RERF-LC-MS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.37763 octreotide LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.67261 Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A3WS-01A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6V3-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K04409515 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35222 MIXL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6408 SRY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.31332 occipital pole, left, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.5694 GEN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54516 BRD-K51779559 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.83916 VMRCRCW CCLE Cell Line Gene CNV Profiles 1.0 1.68584 nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.37629 BRD-K12336887 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7617 FOXO6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.2364 SOX15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46864 PK-45H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.841137 OCIMY5 DepMap CRISPR Gene Dependency 1.0 2.78914 BRD-K02788568 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08685 bcor_22012066_cn_aml_lof_human_gpl570_gds4280 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.01446 ALX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.7442 internal female genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056785 BRD-K55018894 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43633 Galactokinase deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.221 MEIS2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.5425 GBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.4199 HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12418 FOXD2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.1242 ZNF850 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75507 RAD23B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77434 Ommatidium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.627 Hmgn1_KO_GDS5010_407_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null CAL 54 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.897801 BRD-K86077185 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05039 OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.72631 OVTOKO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.73303 SNU620 DepMap CRISPR Gene Dependency 1.0 3.9805 Lower epidermis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.528 CRCGN014_HEPG2_24H:H18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.45043 SNU1214 CCLE Cell Line Gene CNV Profiles -1.0 -2.04851 BRD-K15202679 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14147 KHM1B CCLE Cell Line Gene Expression Profiles 1.0 1.48802 TM6SF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09518 MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.66863 pralidoxim LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25615 BRD-K10171338 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.42941 CRCGN014_HEPG2_3H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.0543 CRCGN014_HEPG2_24H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.39595 laterodorsal subdivision of area 8 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.22722 H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null P53-22387025-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null imatinib_homo sapiens_gpl96_gds3044 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K02100640 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.66532 posteroventral (inferior) parietal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.27035 anteroventral nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.24377 NCIH211 CCLE Cell Line Gene CNV Profiles 1.0 1.99819 H3K4me1_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null cerebellar cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.45782 LS123 DepMap CRISPR Gene Dependency 1.0 2.24782 BRD-K56716645 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22928 PEG10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36498 TCEA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2598 PDP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00675 SNU-423 GDSC Cell Line Gene Expression Profiles -1.0 -1.53857 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7418-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TP63_01_196 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.63227 FOXO4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4597 BPNT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27341 BRD-K03470412 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.02832 BRD-K51295743 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62661 CRCGN017_MCF10A.TP53.M_24H:G11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.15004 sense organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.492572 RFX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6193 BRD-K13567350 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.90821 KE39 CCLE Cell Line Gene CNV Profiles 1.0 1.53976 BRD-A38066207 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.15442 CAPAN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.22853 CRCGN009_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.9765 MAFF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A65B-01A-12R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.028138 BRD-K22608982 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15197 SP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00329 PIAS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.00057 BRD-K56357490 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.88669 ERCC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02729 VIIB, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02554 CRCGN009_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 10.0 INA6 DepMap CRISPR Gene Dependency 1.0 4.37275 primary auditory cortex (core)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01291 CD8+_Tcells BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.848586 H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NFE2-27457419-CHIP-SEQ-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CRCGN010_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.7313 Lung adenocarcinoma_LUAD_TCGA-05-4403-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.51276 MED23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42893 H2AC7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12369 system process GO Biological Process Annotations 2015 1.0 null H3K27me3_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K63504496 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.14902 H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ERCC6L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68397 Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6797-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MEIS3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.1381 ALL-PO GDSC Cell Line Gene Expression Profiles 1.0 1.52369 GSE200673,GSE200691_2_v_4_hmga2_mouse RummaGEO Gene Perturbation Signatures 1.0 null 18801183-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IG-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K07476637 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.0347 mental depression GWASdb SNP-Disease Associations 1.0 0.40647 monastrol-311 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null DLX6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.446 CRCGN015_HEPG2_48H:G06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.43149 H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K61021741 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25492 superficial layers of caudal presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.18121 subiculum, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.15273 medial ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.901258 CRCGN016_MCF10A.WT.HP_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.895 Lens epithelial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.7 BRD-K69480055 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14942 PDS5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26432 Uterine Carcinosarcoma_UCS_TCGA-NA-A4QW-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN013_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.51815 Lens epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.388 ZNF160 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13897 BRD-K96925976 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55488 Photoreceptor outer segment membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.878 BRD-K11923178 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43835 Human lens epithelial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.852 CRCGN015_MCF10A.TP53.M_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.6399 GSE200502_2_v_1_testosterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null SK-UT-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null BCP1 CCLE Cell Line Gene CNV Profiles 1.0 1.47967 BRD-K75100604 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09433 MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K12064774 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23439 Plant primordium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.666 BRD-K17482709 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35685 BRD-K66831269 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53333 RAB3A_Mutation - D77G point mutation_GDS2483_698_mouse_Hippocampus GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null CRCGN015_HEPG2_48H:L01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.18756 CRCGN017_MCF10A.TP53.M_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.88004 ZNF783 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46874 anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.13277 MAGT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67604 M059K Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03743 BRD-K27035180 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26478 IGHMBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92427 G402 CCLE Cell Line Gene CNV Profiles 1.0 1.58274 BRD-K08359838 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.94969 CRCGN015_MCF10A_48H:P06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.71962 NUGC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.897801 FBXL18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84608 ovary BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.96087 SPI1 ChEA Transcription Factor Targets 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TV-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K10701803 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0228 BRD-K53508363 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.88971 Microphthalmia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.814 LRRC45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71063 CRCGN017_MCF10A.WT.HP_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6084 Cataract 44 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.772 primary auditory cortex (core)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.89146 mammalian phenotype MPO Gene-Phenotype Associations 1.0 null BRD-K93176491 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28802 BRD-K74198088 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.16573 STAT1-17558387-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ME-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.841728 KYSE-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.841728 ABL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3512 PCED1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70995 CRCGN009_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.74865 CRCGN014_HEPG2_3H:H01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.67404 COV413A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.82917 ETHE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.27391 Lung squamous cell carcinoma_LUSC_TCGA-66-2754-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K42873980 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35742 METTL14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84721 496100572_HIP_possible Alzheimer's disease_no TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.39485 CRCGN016_MCF10A.TP53.M_24H:O21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.06473 lateral orbital frontal cortex (area 12/47) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.144 EGR1-19032775-M12-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SKBR3 CCLE Cell Line Gene Expression Profiles 1.0 1.45227 TP63 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.6718 ETV5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.05633 MKN-74 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.4404 SK-BR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19563 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5113-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null eye TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.564833 SEM DepMap CRISPR Gene Dependency 1.0 2.03209 SLC2A14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9788 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4341-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A35323217 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04269 EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.45464 adenocarcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053126 primary visual cortex (striate cortex, area V1/17)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.16685 nuclear cataracts MPO Gene-Phenotype Associations 1.0 null BDCA4+_DentriticCells BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -2.56323 PSPH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88854 Perturb_15748_KO_Thap11_SRP065965 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.59291 H4C11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85171 amygdaloid complex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08786 BRD-K83095019 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15856 CTNNB_Activation (deltaNB-cateninER transgenics)_GDS1560_768_mouse_Skin - 7 Day GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K64531971 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39277 Macular degeneration DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.038 22RV1 COSMIC Cell Line Gene Mutation Profiles 1.0 null LHX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.8137 SOX17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63008 CRCGN012_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.3469 ALK_DN.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.13584 inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.66237 Huntington's Disease_CNS - Brain - Striatum (MMHCC)_GSE7958 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.86183 GART CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49183 amygdaloid complex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.94111 REC1 CCLE Cell Line Gene CNV Profiles -1.0 -1.71836 BRD-K20110031 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02069 CRCGN017_MCF10A.WT.HP_24H:P06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5707 planum polare, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.862733 Prostate adenocarcinoma_PRAD_TCGA-HC-7745-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K34721572 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33688 PMC3470785-NIHMS377161-supplement-3.pdf-545-PLAGL1_PLAGL1 Rummagene Transcription Factor Associations 2026 1.0 null SAPCD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47001 G-402 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.80485 RNF207 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09188 III Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.846322 primary visual cortex (striate cortex, area V1/17)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.18044 Sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.071 BRD-K11016405 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12895 DBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59702 CUX1-19635798-MULTIPLE-CANCER-TYPES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null HDAC2 ENCODE Transcription Factor Targets 1.0 null COLO 680N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.903008 HS 746T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0025 ruptured lens capsule MGI Mouse Phenotype Associations 2023 1.0 null Acute contagious conjunctivitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.004 CRCGN015_HEPG2_48H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.67592 CEBPG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1352 abnormal eye development MPO Gene-Phenotype Associations 1.0 null XIAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.23656 EN1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.8514 TP53-23651856-MEF-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null uterus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.070505 Msgn1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.1697 Disease of cellular proliferation DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.29 RERFLCMS CCLE Cell Line Gene CNV Profiles 1.0 2.48584 Amblyopia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.877 LB771HNC DepMap CRISPR Gene Dependency 1.0 2.33282 BRD-K70618663 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40655 IFT25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16903 BRD-K91795767 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26572 EZH2 ENCODE Transcription Factor Targets 1.0 null NCI-H2452 GDSC Cell Line Gene Expression Profiles -1.0 -1.54481 TGFB1I1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33031 BRD-K85615919 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1445 GPX7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56446 inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.972981 DAUDI CCLE Cell Line Gene Expression Profiles 1.0 1.59426 tylosin-tartrate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23135 C3A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0814 CRCGN017_MCF10A.WT.HP_24H:N21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.7044 BRD-K02987495 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05935 BRD-K82570855 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.23563 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN011_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.0605 ZNF45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38324 HPS6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25175 BRD-K46004847 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.83943 SG in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.932033 CRCGN017_MCF10A.WT.HP_24H:P08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.73855 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040661 BRD-K60057192 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16502 KAP1-27257070-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CRCGN014_HEPG2_3H:C06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.02727 EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08937 superior occipital gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.88967 PrefrontalCortex BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.13811 GATA1_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-BF-A1Q0-01A-21R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Juvenile Cataract DisGeNET Gene-Disease Associations 1.0 null sensory perception of light stimulus GO Biological Process Annotations 2025 1.0 null Sclera TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.008 solitary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.980821 THRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 61.118 lens TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null microphthalmia MGI Mouse Phenotype Associations 2023 1.0 null BRD-K84936524 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71761 mRNA_CDX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null CRCGN014_HEPG2_3H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.5794 GM97 BioGPS Cell Line Gene Expression Profiles -1.0 -1.06346 CRCGN008_HEPG2_24H:L04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.2402 PHF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56336 Anisometropia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.413 PLD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94431 PU.1-20176806-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null 496100625_FWM_no dementia_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.10788 CRCGN017_MCF10A.TP53.M_24H:K20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.67316 CRCGN015_MCF10A.WT.HP_24H:A18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.339 SSNA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30999 496100418_TCx_no dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.62651 MAFK ENCODE Transcription Factor Targets 1.0 null icSARS CoV_0Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.45978 PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-upregulated_in_ATF4OE_txt-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K82927098 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34277 PDGF_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.17647 spinalcordlower BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.74598 TE159T CCLE Cell Line Gene Expression Profiles -1.0 -1.48543 PEBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64743 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JB-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PPP1R9B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0142 BRD-K53559383 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.5648 spinal trigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.27076 IFITM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6632 JJN-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02694 OCT4-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K07755570 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33507 BRD-K80950551 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44951 NR2C2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.049 cryga GeneRIF Biological Term Annotations 1.0 null Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null PRKAG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18095 CBR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08332 TPM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86611 EPLC-272H GDSC Cell Line Gene Expression Profiles -1.0 -1.66552 HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.2449 H4C12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36844 BRD-K96997646 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24113 major depressive disorder GWASdb SNP-Disease Associations 1.0 0.539566 NRIP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07055 hyperferritinemia-cataract syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.38 CRCGN015_MCF10A.WT.HP_24H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.75362 JHUEM1 DepMap CRISPR Gene Dependency 1.0 7.97574 CRCGN014_HEPG2_3H:P02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6676 CRCGN017_MCF10A.WT.HP_24H:A21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2312 layer III of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 3.34397 EJM DepMap CRISPR Gene Dependency 1.0 3.39885 H2BC17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.89201 BRD-K42367391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7738 Ca-Ski GDSC Cell Line Gene Expression Profiles 1.0 1.45293 RMUGS DepMap CRISPR Gene Dependency 1.0 8.33675 H3K27me3_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PAX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68869 cervical cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.106781 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4882-01A-02R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K74892102 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.98082 future GeneRIF Biological Term Annotations 1.0 null P300-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Lens fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.671 structural molecule activity GO Molecular Function Annotations 2015 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5703-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null D-566MG GDSC Cell Line Gene Expression Profiles -1.0 -2.13133 A375 GDSC Cell Line Gene Expression Profiles 1.0 1.66979 CTV1DM DepMap CRISPR Gene Dependency 1.0 2.87989 ETV2::FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.8423 BRD-K84073439 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31749 BRD-K47083242 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56003 ZNF77 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.92851 POLR2H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27915 pyramidal layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.06682 CUX1-19635798-MULTIPLE HUMAN CANCER CELL TYPES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1HV-06A-21R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K66700691 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18568 dentate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.85549 medial intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02886 CRCGN010_HEPG2_24H:G16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.52192 EGR1-19032775-M12-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K12099407 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13356 NNAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82962 MZ in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.68777 vacuolated lens MPO Gene-Phenotype Associations 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A7R8-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ADRM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53457 Molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.729 HEP G2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30675 AICD_Induced expression / Over-expression_GDS1979_288_human_SHEP-SF neuroblastoma GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K42679315 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.95581 CRCGN015_HEPG2_48H:M17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.77731 Silique TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.898 NRARP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5292 Connexin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.151 Rarb JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 59.4583 reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052787 HOXC13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.2613 KM12 BioGPS Cell Line Gene Expression Profiles 1.0 1.24529 BRD-K51140037 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59834 CRCGN015_MCF10A.TP53.M_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.02175 BRD-A59683007 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02911 ORMDL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43218 astrocytes BioGPS Cell Line Gene Expression Profiles -1.0 -1.20453 H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K07460436 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69512 DBTRG-05MG GDSC Cell Line Gene Expression Profiles -1.0 -1.88608 DFCI024 CCLE Cell Line Gene Expression Profiles 1.0 2.14679 BRD-K93295557 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13518 VIIAt Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.991222 microphthalmia MPO Gene-Phenotype Associations 1.0 null GSE200673,GSE200691_1_v_5_hmga2_mouse RummaGEO Gene Perturbation Signatures 1.0 null outer SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.21893 KPNYN DepMap CRISPR Gene Dependency 1.0 2.54287 TIMM8B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55384 TP53-23651856-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null motor nucleus of trigeminal nerve, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.856322 RS4-11 COSMIC Cell Line Gene Mutation Profiles 1.0 null UXT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36213 BRD-K95499061 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01608 METTL18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23139 MHH-ES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39086 KATOIII COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN012_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.67585 subiculum, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.0262 BRD-A44068497 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31959 CRCGN017_MCF10A.TP53.M_24H:K03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.63657 MAFF ENCODE Transcription Factor Targets 1.0 null CREB1 JASPAR Predicted Transcription Factor Targets 1.0 null animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051421 BRD-K25176380 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3404 abnormal lens capsule morphology MPO Gene-Phenotype Associations 1.0 null BRD-K00816476 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10321 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4847-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null JUNB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29946 IFNGR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74611 GSE158197_2_v_11_egfr_mouse RummaGEO Gene Perturbation Signatures 1.0 null Retinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.176 Lung squamous cell carcinoma_LUSC_TCGA-85-A5B5-01A-21R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Age related macular degeneration DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.103 anterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.02427 BRD-K32214429 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58333 lensalpha GeneRIF Biological Term Annotations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5751-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K40474424 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23486 ACTN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90997 EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null levallorphan-tartrate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13426 BRD-K51697562 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29549 H3K27me3_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPDEF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.1073 HOXC6_01_333 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.33682 CRCGN008_HEPG2_24H:F10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4931 ventrolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.30132 BRD-K21662756 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.27514 H3K27me3_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null sensory perception of light stimulus GO Biological Process Annotations 2023 1.0 null NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.33691 SDHB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62258 BRD-K28433349 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72179 pentolinium LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59519 ZNF71 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00824 Rhox11 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.6597 TEAD2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.6402 Uterine Carcinosarcoma_UCS_TCGA-N8-A4PP-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ECGI10 CCLE Cell Line Gene CNV Profiles -1.0 -1.70101 ZNF16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.389 CRCGN013_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.28286 mediodorsal nucleus of thalamus_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.15739 beta GeneRIF Biological Term Annotations 1.0 null HCC1954 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19563 CRCGN014_HEPG2_24H:D01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.30726 ZNF226 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35431 FGFR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5289 496100469_TCx_no dementia_TBI_89_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.75774 SFSWAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43299 CRCGN015_HEPG2_48H:L02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.60741 lens disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.25254 MRPS23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88304 MTFR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65547 HSF1_KD_GDS1733_754_human_HeLa cells - 0 Hour by siHSF1_2 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null TCF19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42684 TMEM181 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03732 RAB3A_Mutation - D77G point mutation_GDS2482_704_mouse_Hippocampus GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Brain disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.29 C18orf32 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51478 GSE158197_6_v_3_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null lateral nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05499 JL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.98171 PROSER3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57375 BRD-K58932103 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.38378 GOSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0652 cataracts MPO Gene-Phenotype Associations 1.0 null CRCGN009_HEPG2_24H:F20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.1756 CRCGN015_MCF10A_48H:P04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.3643 DDX43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00817 LITAF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78608 TONSL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93496 TGIF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.8025 CRCGN014_HEPG2_24H:F21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.63201 HDQP1 CCLE Cell Line Gene Expression Profiles -1.0 -2.05147 posteroventral (inferior) parietal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.913145 BRD-K18094884 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10804 preoptic region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.5144 cuneate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.10538 VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.07633 CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal lens fiber morphology MPO Gene-Phenotype Associations 1.0 null WDFY2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65677 HCC2935 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.848311 GTF2E2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58853 CEBPG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.4467 central nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.882503 ATOH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25892 CRCGN014_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.01681 BRD-K54317642 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.82694 striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.5267 BRD-K11188962 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.066 subjected GeneRIF Biological Term Annotations 1.0 null OKAJIMA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12312 HOXA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83823 Cornea plana DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.022 Ebolavirus(EBOV)_1day_PBMCs_17725815_GSE8317 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 0.290254 BCLAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91938 CHP126 CCLE Cell Line Gene CNV Profiles 1.0 1.93983 CRCGN014_HEPG2_24H:D13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.73624 BRD-K59893572 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65313 BRD-K89364982 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01901 BRD-K77498991 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16471 BRD-K84158675 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47402 BRD-K05223209 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.73926 primary auditory cortex (core)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.80558 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RK-02A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K12411112 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.79297 BRD-K41603100 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25578 PNPLA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14675 ACP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74467 BRD-K23147993 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15317 MITF ChEA Transcription Factor Targets 1.0 null anterior hypothalamic area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.57663 EN COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K60946512 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1614 HL60 CCLE Cell Line Gene Expression Profiles 1.0 1.49873 SMARCD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82676 ASPC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.897801 FOXP2-21765815-NEURO2A-MOUSE ChEA Transcription Factor Targets 2022 1.0 null SOCS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13741 abnormal anterior eye segment morphology MPO Gene-Phenotype Associations 1.0 null HMEL CCLE Cell Line Gene Expression Profiles 1.0 2.66635 BRD-K34004579 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05726 BRD-A87325732 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39963 TMEM184C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92719 ZNF224 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62402 HOXB7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.4156 CRCGN016_MCF10A.TP53.M_24H:O18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.66015 HCC2998 BioGPS Cell Line Gene Expression Profiles 1.0 1.24529 CYB561D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98696 CTSL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23393 ZNF121 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55748 BRD-K42016545 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69264 CardiacMyocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 2.2603 IRF2BPL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09493 SAC3D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55826 Adrenocortical carcinoma_ACC_TCGA-OR-A5JB-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K20026212 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19333 PPP2R1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14774 DG-75 COSMIC Cell Line Gene Mutation Profiles 1.0 null Zic3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.8709 Uterine Carcinosarcoma_UCS_TCGA-N8-A4PQ-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K08212599 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08141 NACA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78296 anterior (rostral) cingulate (medial prefrontal) cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.40429 DPY-21335234-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null NR1D1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.8886 VI, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.95784 MARVELD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50877 TOLLIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19026 HCC38 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.89827 FOXL1 JASPAR Predicted Transcription Factor Targets 1.0 null Asthma_Epithelial Cell_GSE4302 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.46323 GSE144838_2_v_5_egfr_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE201401_2_v_0_fgfr1_mouse RummaGEO Gene Perturbation Signatures -1.0 null KURAMOCHI COSMIC Cell Line Gene Mutation Profiles 1.0 null Vitreous humor TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.148 retina BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 BRD-K96839404 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0662 BRD-K51681402 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02544 LRRC59 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5471 MYO18A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16275 CRCGN017_MCF10A.WT.HP_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.55485 721_B_lymphoblasts BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.939267 BRD-K09373762 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.07481 BRD-K84052780 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.08686 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040465 BRD-K59708864 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19566 H3K27me3_Adipose Nuclei Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NOL11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 5.9248 SH2D5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6301 BRD-K52361779 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0092 TP73 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.0737 BRD-K02793474 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01638 BRD-K69922285 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.48579 ZNF239 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73922 Paw TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.59 STAT1::STAT2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.4581 CRCGN009_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8697 NT5C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22265 HOXA10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.70854 HSPA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86257 RNF130 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19453 IFRD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.07319 BRD-K99265073 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00617 PIK3IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67045 cataract GeneRIF Biological Term Annotations 1.0 null Sarcoma_SARC_TCGA-X6-A7W8-01A-21R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DNAJB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62685 vision/eye phenotype MPO Gene-Phenotype Associations 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TM-A7CA-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF572 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23744 Lens nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.66 HS578T Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.86555 pancreas BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.46784 cataract GAD Gene-Disease Associations 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7II-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65202 CTTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33109 HGS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71978 KASUMI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.18514 Ciliary body TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.118 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.485 RPL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90445 Rectum adenocarcinoma_READ_TCGA-F5-6814-01A-31R-1928-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K50210179 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34255 ALKBH5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77403 Perturb_10643_KO_Tdrd7_SRP214975 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.03625 CCDC71L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76036 BRD-K74363294 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14767 SLC36A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46821 BRD-K82827604 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54921 VIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.99084 PMC12211354-12915_2025_2224_MOESM6_ESM.xlsx-Sheet1-Sheet1_The_source_list_of_zebrafish_Npas4b_targets_from_human_NPAS4_targets_in_CHEA3_database_NPAS4 Rummagene Transcription Factor Associations 2026 1.0 null EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12312 SNU-638 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.54061 BRD-K40011635 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69551 GSE112761,GSE112767_1_v_5_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN009_HEPG2_24H:M19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.2963 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09292 BRD-K28429328 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30516 gammacrystallinsare GeneRIF Biological Term Annotations 1.0 null cell-cell junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.175745 CDX2-21402776-INTESTINAL-VILLUS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CRCGN015_HEPG2_48H:P05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.89724 RH-1 GDSC Cell Line Gene Expression Profiles -1.0 -1.94386 H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null APLN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76981 BRD-K28082924 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.9138 outer SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.28697 U2AF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0955 EVSAT CCLE Cell Line Gene CNV Profiles 1.0 1.44996 EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.902019 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YI-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cardiovascular Abnormalities CTD Gene-Disease Associations 1.0 1.02336 OUMS-23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.88159 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3ML-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KYSE-150 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.51894 ZNF250 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75837 NET1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93778 PMF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02647 Liver BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.00897 PF382 CCLE Cell Line Gene Expression Profiles -1.0 -2.1783 Retinal degeneration DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.04 BRD-A42246453 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72705 KP-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null FLI1::DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.704 Prostate adenocarcinoma_PRAD_TCGA-HC-8265-01A-11R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null parasubicular cortex (parasubiculum) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13835 KLF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.9518 PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-RELA_DN_V1_UP-Gene_name_RELA Rummagene Transcription Factor Associations 2026 1.0 null WDR20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11898 PUF60 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20862 HELA BioGPS Cell Line Gene Expression Profiles 1.0 1.34733 CCNF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89472 TES CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16584 SUDHL10 CCLE Cell Line Gene Expression Profiles 1.0 2.47355 SW403 DepMap CRISPR Gene Dependency 1.0 2.11151 Inflammation CTD Gene-Disease Associations 1.0 1.32786 BRD-K51370144 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5474 SG in dysgranular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.849653 CRCGN014_HEPG2_3H:B08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.5132 PDZD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76738 RELA_DN.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null IBTK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52878 CRCGN016_MCF10A.TP53.M_24H:O15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.67583 H3K4me1_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null crygb GeneRIF Biological Term Annotations 1.0 null CRCGN013_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.71074 BRD-K20733942 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48231 anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.08864 COR-L105 GDSC Cell Line Gene Expression Profiles 1.0 1.50446 BRD-K84241565 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.57545 KYSE-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.57428 GORAB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04719 PRRX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.246 neuro2a BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.870534 furazolidone LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.27481 BRD-K45712538 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37815 PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-RELA_DN_V1_UP-Ensemble_gene_ID_RELA Rummagene Transcription Factor Associations 2026 1.0 null CD14+_Monocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.848586 TET2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54241 CRCGN016_MCF10A.TP53.M_24H:E17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.13107 CRCGN017_MCF10A.WT.HP_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8537 BRD-K70992537 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1098 HCC364 CCLE Cell Line Gene Expression Profiles 1.0 1.50883 carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052082 BRD-K76713298 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74241 BRD-K62942008 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39183 Lens TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.669 LN229 CCLE Cell Line Gene Expression Profiles 1.0 1.47831 LBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.5256 stratum radiatum of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.26414 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1IB-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SPI1-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null STAT6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22646 SHSY5Y CCLE Cell Line Gene Expression Profiles -1.0 -1.5015 CRCGN009_HEPG2_24H:L08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.4803 STAMBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16019 AOC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04487 BRD-K96284156 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09231 extracellular region LOCATE Predicted Protein Localization Annotations 1.0 null TAF9B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71826 LS-180 COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.1723 BRD-K15343767 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.66684 DDX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86265 NCIH1568 CCLE Cell Line Gene Expression Profiles -1.0 -1.4529 brain GTEx Tissue Gene Expression Profiles 1.0 2.15748 urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052007 FOXP2-21765815-NEURO2A-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-1622-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DU4475 CCLE Cell Line Gene Expression Profiles 1.0 2.24018 DPY19L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30488 MTHFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16544 APEX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.68043 Iris disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.468 Lung adenocarcinoma_LUAD_TCGA-NJ-A4YF-01A-12R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MEF2D JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.9549 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.92554 CRCGN014_HEPG2_3H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.06474 stratum radiatum of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.31252 cataract DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.25297 ZNF341 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6424 PRMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12756 BRD-K75869095 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56113 medial mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19619 KMM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16658 STAT3-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K96183125 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00768 CRCGN015_HEPG2_48H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.28751 GLTP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35659 inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.45782 HSC-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null INPP5E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06443 Calu-6 GDSC Cell Line Gene Expression Profiles 1.0 1.91876 Crus II, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.882002 H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K82224868 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45728 BRD-K44203030 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20698 BRD-K32120119 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.53185 FOXK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.7898 Peters anomaly DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.222 DLX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.4372 carcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054013 cognitive disorder GWASdb SNP-Disease Associations 1.0 0.092184 BRD-K79735667 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30893 spleen BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.23083 BRD-K64449549 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25991 BRD-A04231641 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38387 CRCGN015_HEPG2_48H:P06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.92188 primary motor cortex (area M1, area 4)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.914529 Cataract DisGeNET Gene-Disease Associations 1.0 null novobiocin-na LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.64405 Cataract HuGE Navigator Gene-Phenotype Associations 1.0 null ARHGDIA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99349 SETDB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28233 BAG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0622 MAFK_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MPV17L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68554 basis GeneRIF Biological Term Annotations 1.0 null UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.903008 JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.4073 inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.26415 CRCGN008_HEPG2_24H:G24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.1824 CRCGN010_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.91535 CRCGN014_HEPG2_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.55391 KCNS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91847 NCI-H2009 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15284 SP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.977528 H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF350 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01598 layer III of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.39431 DU4475 DepMap CRISPR Gene Dependency 1.0 4.40969 BRD-K55218521 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25537 SHOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01083 hsa-miR-643 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A85J-01A-12R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.97269 CRCGN014_HEPG2_24H:A20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.94447 NCI-H1373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00234 RGL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78106 RPS6KA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02518 KYSE-70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.902019 CTNNB_Activation (deltaNB-cateninER transgenics)_GDS1560_767_mouse_Skin - 1 Day GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.45553 Kidney Chromophobe_KICH_TCGA-KL-8345-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K42480393 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22696 METTL25B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38949 BRD-K54881917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3408 BRD-K78196882 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63001 CHST3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65368 BRD-K76672145 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.3013 posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.10682 BRD-K43528099 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04426 BRD-K59747214 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.50825 HUT102 CCLE Cell Line Gene Expression Profiles 1.0 1.41752 Presbyopia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.283 BRD-K65780164 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32685 V, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.23501 BRD-K37454185 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29439 TM7SF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76846 BRD-K57830670 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3615 DMRTA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57647 primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.05569 NF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86499 GSE158197_6_v_10_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RK-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CDCA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67777 CRCGN014_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.2353 C32 CCLE Cell Line Gene CNV Profiles 1.0 1.47201 ETV5::FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.9388 SOX11-22085726-ESNS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE158197_6_v_4_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null PLEKHO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64746 NCI-H2804 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.919616 Tadpole TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.204 Heavy chain immunoglobulin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.5 Ppara JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.6281 anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.856849 CRCGN011_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.94465 ETFDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18966 adenocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057461 SUM185PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.859111 MAVER1 DepMap CRISPR Gene Dependency 1.0 4.13355 abducens nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.974349 H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FBXO7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67931 GSE200502_0_v_1_testosterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null abnormality of the nervous system GWASdb SNP-Phenotype Associations 1.0 0.038854 PFKL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27299 BRD-K03370561 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13528 L1TD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13293 Chamber of the eye TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.112 KLF9_Deficiency_GDS2703_647_mouse_Jejuna - intestine GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null CCNG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87226 OCIAD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42986 H3K27me3_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXP2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.658 ventrolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.28569 PANC1 CCLE Cell Line Gene Expression Profiles 1.0 1.89226 AM-38 COSMIC Cell Line Gene Mutation Profiles 1.0 null ANKRD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45092 CRCGN009_HEPG2_24H:F19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.5163 ARL6IP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6275 AMO-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null eye TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null abnormal eye size MPO Gene-Phenotype Associations 1.0 null HCC2218 CCLE Cell Line Gene Expression Profiles 1.0 1.81984 BRD-K21483524 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19539 NCIH2227 CCLE Cell Line Gene CNV Profiles 1.0 2.15637 H3K27me3_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HT144SKINFV2 DepMap CRISPR Gene Dependency 1.0 5.32773 BRD-K84815485 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.36316 Retinitis pigmentosa 29 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.501 BRD-A13983189 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56225 GSTP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.87093 F36P DepMap CRISPR Gene Dependency 1.0 2.67745 BRD-K10876822 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.804 GSE128240_0_v_1_cyclophosphamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null Cataract 38 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.514 RORC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21168 VI Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.855086 CRCGN014_HEPG2_3H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.65815 CRCGN016_MCF10A.TP53.M_24H:H08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.58875 GATA1_G1E-ER4_mm9_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null GOLGA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02584 TTLL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03314 COV413B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.78437 Refractive error DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.591 striatum_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.56684 GSE133683_3_v_0_doxorubicin_mouse RummaGEO Drug Perturbation Signatures 1.0 null ZNF333 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19761 CRCGN014_HEPG2_24H:P01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.5895 serine-tRNA ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.825 external granular (germinal) layer of lower rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33605 Axenfeld-Rieger syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.447 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Brain glioma DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.29 Bilateral Cataracts (Disorder) DisGeNET Gene-Disease Associations 1.0 null DEGS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20948 496100383_HIP_no dementia_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.08512 BRD-K19693607 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17907 Iritis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.044 BRD-K53893978 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09396 HuO-3N1 GDSC Cell Line Gene Expression Profiles 1.0 1.63339 BRD-K15393664 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01523 NCI-H1155 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTNNB1_Inactivation_GDS2984_628_mouse_Intestinal crypts GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null ANAPC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15227 5637 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K37479727 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20752 UNC50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42654 OCT4-21477851-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CPXM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04797 vision GAD High Level Gene-Disease Associations 1.0 0.293278 BRD-K47658117 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08123 GSE94011_2_v_1_pias3_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K27028848 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65083 HMX1_Deficiency_GDS4810_324_mouse_Retinas of C57BL/6J GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K38787519 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50587 VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.36602 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MM-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN009_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.00622 PHETA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99854 laterorostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.35907 E2F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71752 496100366_TCx_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.04101 NCIH2066 CCLE Cell Line Gene CNV Profiles 1.0 1.40617 PRSS53 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94571 UROS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81978 CRCGN009_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8395 SOX21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27088 PNRC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09139 JJN3 DepMap CRISPR Gene Dependency 1.0 2.16031 ARID3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33191 CRCGN017_MCF10A.WT.HP_24H:O21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5544 CUX1 ChEA Transcription Factor Targets 1.0 null epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051929 HTR7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52638 caudal (posterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.75055 MNDA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08121 ATG12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86222 PARP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60573 Gli1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.4654 MPP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72316 CRCGN009_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.21654 KYSE30 CCLE Cell Line Gene CNV Profiles -1.0 -1.40814 TC32 CCLE Cell Line Gene Expression Profiles 1.0 1.59153 SLC39A8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18174 BRD-K64111129 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42253 BRD-K69087429 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.86923 ITGB3BP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09375 BRD-A73150064 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.82031 Whole Blood GTEx Tissue Gene Expression Profiles 2023 1.0 3.08975 STK36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.96753 PIGO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88012 BRD-K43431234 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.36521 DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.1334 TCTN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9752 BT474 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.06603 POLDIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34915 HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06119 A-498 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.835114 CRCGN016_MCF10A.WT.HP_24H:N14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.2042 TEAD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8169 ZNF880 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38289 MAFK_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Optic atrophy 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.186 BRD-K44955380 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00543 BHT101 CCLE Cell Line Gene Expression Profiles -1.0 -1.56896 CRCGN015_HEPG2_48H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.90568 C32TG Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00234 abnormal lens development MPO Gene-Phenotype Associations 1.0 null stratum pyramidale of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04403 BRD-K87080934 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36171 BRD-K87023633 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41016 FEZF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52078 cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.728 Anterior segment dysgenesis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.006 RET_mutant_23_GDS3319 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.58731 abnormal lens fiber morphology MGI Mouse Phenotype Associations 2023 1.0 null HMGA2_KO_GDS5048_26_mouse_embryonic lung GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null ERRFI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33874 HOXA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21519 BRD-K43543979 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03647 BRD-K02548315 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11108 Abruzzo-Erickson syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.413 Lung BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.46169 HCT-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.18514 RHOV CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88876 basomedial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.10929 BRD-A67521865 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.61667 CRCGN017_MCF10A.WT.HP_24H:P09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.05385 Eye TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.132 CRCGN016_MCF10A.WT.HP_24H:K20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.48285 VIIIA, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.06709 major GeneRIF Biological Term Annotations 1.0 null PA-TU-8988S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.919616 496100670_TCx_probable Alzheimer's disease_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.58348 SYN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22533 LU-135 COSMIC Cell Line Gene Mutation Profiles 1.0 null HDMYZ CCLE Cell Line Gene Expression Profiles -1.0 -1.59609 BRD-K27398402 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61825 H3K27me3_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETV5::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.9353 PLCB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45086 Skin Cutaneous Melanoma_SKCM_TCGA-D9-A4Z6-06A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3316-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K64132098 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05335 KYSE270 CCLE Cell Line Gene Expression Profiles 1.0 1.90474 SP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.839566 female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053884 H3C4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23516 496100432_TCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.50131 chemdependency GAD High Level Gene-Disease Associations 1.0 0.293278 GSE144115_1_v_3_stag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K26976202 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.81894 SET2 DepMap CRISPR Gene Dependency 1.0 3.62231 CNNM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33087 IRF2BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21002 SETDB1-19884255-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K73479560 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.26563 MREG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80671 GON4L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76766 VAPB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3698 COLO205 BioGPS Cell Line Gene Expression Profiles 1.0 0.857017 AP4B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83632 Necrosis CTD Gene-Disease Associations 1.0 1.27782 ZKSCAN1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.0284 MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null SG in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.14723 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5885-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K35788497 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07735 CTXN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51411 DICER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23005 CRCGN014_HEPG2_24H:F03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.99639 NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18886 KE-37 COSMIC Cell Line Gene Mutation Profiles 1.0 null RALGDS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.29013 CRCGN017_MCF10A.WT.HP_24H:E10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.2454 CRCGN017_MCF10A.TP53.M_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.2512 BRD-K73355908 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00091 CRCGN014_HEPG2_3H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.8232 MKN1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Edinger-Westphal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.835785 Gamma-crystallin-related InterPro Predicted Protein Domain Annotations 1.0 null TOV-112D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.897801 CAL72 DepMap CRISPR Gene Dependency 1.0 2.06512 Meningococcal infection_Umbilical vein_GSE4646 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.41798 bergapten LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41837 CRCGN016_MCF10A.WT.HP_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.73563 NDUFS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5249 SNU-C5 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE133764_2_v_0_chd2_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K82249895 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.17109 head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055601 BBX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43136 Axenfeld-Rieger syndrome type 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.023 PTEN_KD_GDS2958_99_human_A431 - EPIDERMOID carcinoma cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null CRCGN015_MCF10A_48H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.37535 G0S2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30907 496100431_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.79706 H3K4me1_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Organ system cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.29 ZNF547 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.5263 BRD-K26272845 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13155 single-organism process GO Biological Process Annotations 2015 1.0 null deep layers of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.855055 orbital frontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.925567 ELF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.5994 ESS-1 GDSC Cell Line Gene Expression Profiles -1.0 -1.75173 SNU840 CCLE Cell Line Gene CNV Profiles -1.0 -1.32854 ATF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.7887 H3K27me3_Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SPI1-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null HUH1 CCLE Cell Line Gene CNV Profiles 1.0 1.97425 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4224-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDAMB436 CCLE Cell Line Gene CNV Profiles -1.0 -1.45505 VIIIA, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.37297 BRD-K27137352 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8858 CRCGN014_HEPG2_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2659 posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.996146 CRCGN015_MCF10A_48H:H22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.94291 Tail muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.637 constantly GeneRIF Biological Term Annotations 1.0 null BRD-K50417536 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18037 BRD-K20171002 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12919 MZ in dorsomedial parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.885965 CRCGN015_HEPG2_48H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.48305 gigantocellular reticular nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.4165 thyroid BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.955834 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5374-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-5274-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RARA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.5061 KYSE-520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.97533 Sarcoma_SARC_TCGA-K1-A6RU-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAB26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61188 PDCL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27392 LP1 DepMap CRISPR Gene Dependency 1.0 3.8463 CHD1 ENCODE Transcription Factor Targets 1.0 null NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.919616 ventricular (matrix) zone of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.02832 H3K4me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_HEPG2_48H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.20573 Fallopian Tube GTEx Tissue Gene Expression Profiles 2023 1.0 3.08975 Sense organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN009_HEPG2_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.91853 BRD-K56343202 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69665 RING1B-27294783-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Matrilin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.911 A-CA-04-2009(H1N1)_0Hour_None_GSE37571 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.14405 MITF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.234 FGFR3_knockdown_173_GSE41035 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.99482 H3K27me3_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lens disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.964 GATA3-24758297-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null COLO 853 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15402 frequency GeneRIF Biological Term Annotations 1.0 null TTC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89672 496100357_TCx_no dementia_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.40972 G130 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.964369 BRD-K72351789 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52209 BRD-K28122619 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.9118 Crus I, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.944078 MAFF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MKKS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32175 MEF2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.9385 ACTR1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54897 BRD-K30510226 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21167 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4691-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN009_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.49199 STAT3_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K10580455 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.26504 Lung squamous cell carcinoma_LUSC_TCGA-60-2724-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MRPS33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93429 HT1197 CCLE Cell Line Gene CNV Profiles -1.0 -1.59963 DHX35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67497 OAW42 CCLE Cell Line Gene Expression Profiles 1.0 1.36107 ZNF524 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.08161 FZD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60268 LB1047RCC DepMap CRISPR Gene Dependency 1.0 3.44947 BRD-K56149020 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26194 SLC16A13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15572 CLBA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87709 MXD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40061 CRCGN017_MCF10A.WT.HP_24H:P10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.2931 NCI-H23 COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN012_HEPG2_24H:G07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.82559 C4orf36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71026 IRF9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.8844 PROKR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72705 BRD-K37331547 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24329 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.93749 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2M5-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TPRA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81793 NAAA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45583 PPP2R5D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32861 anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.52576 BRD-K43570522 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1162 KLHL42 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98863 Liver hepatocellular carcinoma_LIHC_TCGA-QA-A7B7-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posteroventral (inferior) parietal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.943675 H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null MSTO211H DepMap CRISPR Gene Dependency 1.0 2.61289 amygdaloid complex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.18201 Eye TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 central nuclear group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10044 USP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0381 Brain - Spinal cord (cervical c-1) GTEx Tissue Gene Expression Profiles 2023 1.0 1.57296 BRD-K28982281 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51106 BRD-K74677971 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28219 IL17RA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4016 DGKA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25489 facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.930944 ATN-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-A06840811 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51295 BRD-K45222498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.34068 primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.19696 LYSMD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07034 PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-2q37_1_TP63 Rummagene Transcription Factor Associations 2026 1.0 null SK-MEL-28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.846965 CRCGN016_MCF10A.TP53.M_24H:P14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.06883 P4HB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09887 BRD-K05977380 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.14657 mediodorsal nucleus of thalamus_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.50643 choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.42398 ZNF277 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36372 Familial combined hyperlipidaemia_Blood monocyte_GSE11393 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.57685 BRD-K56272400 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60755 b18 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.523 Interphotoreceptor matrix TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.509 CRCGN016_MCF10A.TP53.M_24H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.61416 YPEL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92099 reuniens nucleus (medioventral nucleus) of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.902487 AXL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49863 CRCGN015_HEPG2_48H:J10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.14978 CRCGN012_HEPG2_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.56488 amygdaloid complex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.90573 rostral subdivision of medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33286 CRCGN015_HEPG2_48H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 9.8141 APOBEC3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.2701 HDLM2 CCLE Cell Line Gene CNV Profiles -1.0 -1.93994 primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.33735 BRD-K02199688 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22463 indusium griseum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.49585 Uveitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.026 pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN017_MCF10A.WT.HP_24H:K23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.32205 STAT3 ENCODE Transcription Factor Targets 1.0 null CRCGN017_MCF10A.WT.HP_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.91045 EGR3_01_34 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.38577 CRCGN014_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.3937 PRDM1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.4761 CRCGN016_MCF10A.WT.HP_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.55915 16207381-Table1Sa GeneSigDB Published Gene Signatures 1.0 null TMEM216 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66677 BRD-K09903493 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2655 PLBD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6722 inferior olive, medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.879569 Edema CTD Gene-Disease Associations 1.0 1.01663 BRD-K59535072 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09553 Aniridia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.368 primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.957927 CAPAN1 CCLE Cell Line Gene CNV Profiles 1.0 1.58473 NFYC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22722 SAP30L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91505 CRCGN015_MCF10A.TP53.M_24H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.4959 BRD-K64730761 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5299 BRD-K93698227 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07767 BATF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74987 Cervix - Endocervix GTEx Tissue Gene Expression Profiles 2023 1.0 2.07856 primary auditory cortex (core)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.969496 mediodorsal nucleus of thalamus_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.27705 Small Intestine - Terminal Ileum GTEx Tissue Gene Expression Profiles 2023 1.0 1.57296 ZNF551 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73601 hippocampus (hippocampal formation)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07196 CXXC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30564 Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.29 HHUA DepMap CRISPR Gene Dependency 1.0 5.98667 EN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81174 occipital pole, left, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.23588 BT-549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.57428 GATA4_INACTIVATION_GDS3663_519_mouse_Endothelial-derived cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null ZNF148 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97339 organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052963 Deprivation amblyopia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.615 NNMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.27544 nobox_18509161_newborn_ovary_lof_mouse_gpl1261_gds3254 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.004447 primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.80778 BRD-A11130173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.77084 BRD-K04883778 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10595 inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.46356 PAWR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13426 ZNF257 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.79067 ISX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.6823 b220.bcell BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.49497 neurological system process GO Biological Process Annotations 2015 1.0 null I-II Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.21601 Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7591-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ANKS1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64123 BRD-K79568363 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16565 CRCGN012_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.69249 single-organism developmental process GO Biological Process Annotations 2015 1.0 null CRCGN014_HEPG2_24H:E19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.06982 CEBPB ENCODE Transcription Factor Targets 1.0 null CRCGN015_HEPG2_48H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.68641 KLF16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58572 MAPRE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46468 PTMS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26185 primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.19696 BRD-K50472386 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.21982 sense organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K27me3_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K06208179 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12173 TRIM41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89181 BRD-K38227596 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20174 depression GWASdb SNP-Phenotype Associations 1.0 0.46012 SP in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0468 PC14 CCLE Cell Line Gene CNV Profiles -1.0 -1.53707 CRCGN011_HEPG2_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.0993 BRD-K74896637 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21174 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.2545 BRD-K28764680 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08829 KKU100 DepMap CRISPR Gene Dependency 1.0 2.23408 LARP4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48534 C32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.15266 Senile cataract DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.291 COV318 CCLE Cell Line Gene CNV Profiles 1.0 1.41944 BRD-K68078571 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05798 Nonnuclear Polymorphic Congenital Cataract DisGeNET Gene-Disease Associations 1.0 null Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.484 CRCGN011_HEPG2_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.2095 DHX40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22128 BRD-A70099008 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62883 CDC42SE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63014 SPP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48728 CRCGN017_MCF10A.WT.HP_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.19375 IRF8-27001747-CHIP-SEQ-BMDM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null lateral hypothalamic area, anterior region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 3.26578 CRCGN015_MCF10A.TP53.M_24H:P15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.22365 INPPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6858 PRKCA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5802 dentate gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.98738 BRD-K14449601 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45947 NUMBL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33373 agranular insular cortex (area Iag) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08144 CRCGN014_HEPG2_3H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.0589 GFER CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47354 BRD-K70940767 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20839 CRCGN014_HEPG2_24H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.6606 MHH-NB-11 GDSC Cell Line Gene Expression Profiles -1.0 -1.81858 RMDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.80291 IRF8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.3628 IKZF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64825 NEUROD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87815 VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.9592 BRD-A98888138 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.73934 Weight Loss CTD Gene-Disease Associations 1.0 1.15797 DMNB LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 6.20712 Head TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 EZH2_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Charcot-Marie-Tooth disease type 4F DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.112 METTL17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3989 ZNF410 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.4159 CRCGN014_HEPG2_3H:P19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.35147 BRD-K45723655 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68437 BRD-K82107155 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4858 GSE230354_0_v_1_rheb_mouse RummaGEO Gene Perturbation Signatures -1.0 null ventromedial hypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.45623 Liver GTEx Tissue Gene Expression Profiles 2023 1.0 1.57296 SCRT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.8365 Crus I, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.04162 Other Cataract DisGeNET Gene-Disease Associations 1.0 null Central nervous system cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.29 CRCGN014_HEPG2_24H:B08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.89 anatomical structure development GO Biological Process Annotations 2015 1.0 null BRD-K97064059 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00563 GPX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83119 KIAA1549 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.26678 retina TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.317679 MDAMB157 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.07685 CRCGN015_HEPG2_48H:G04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.47745 VZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.69342 primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04119 NRL_DN.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null EID1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95716 CRCGN014_HEPG2_3H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.64016 ZNF717 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52355 anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.838665 epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050929 HUH-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.72855 CAPZB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58189 PDX1 JASPAR Predicted Transcription Factor Targets 1.0 null COLO679 CCLE Cell Line Gene CNV Profiles 1.0 1.65691 gata1_15895080_e12dot5_liver_megakaryocyte_lof_mouse_gpl1261_gds1316 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.219771 SNU1544 DepMap CRISPR Gene Dependency 1.0 9.66602 TUHR14TKB DepMap CRISPR Gene Dependency 1.0 2.38344 ARX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24474 CRCGN016_MCF10A.WT.HP_24H:C07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.67887 DLX5_KO_GSE22381_5_mouse_ear (otic vesicle) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null CCDC142 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54606 POU5F1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71788 HL60 BioGPS Cell Line Gene Expression Profiles -1.0 -2.08881 lateral hypothalamic area, mammillary region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.852472 GTF3C6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42295 Brain Lower Grade Glioma_LGG_TCGA-R8-A6YH-01A-21R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IDH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55992 SERINC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.01383 KYSE-140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18886 SGTB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65792 ZNF35 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.8904 CRCGN015_HEPG2_48H:J16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.63236 inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.70369 HCC44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.871029 BRD-K93942001 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22908 globus pallidus, internal segment, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.856344 CRCGN016_MCF10A.WT.HP_24H:D04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.0734 PHARC syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.288 BRD-K36422663 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40768 BRD-K82460510 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21024 EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ARPC1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63802 BRD-K76294510 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23847 DNASE1L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33262 CRCGN015_HEPG2_48H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.49911 PDRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92321 PRAG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11753 CRCGN010_HEPG2_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.03042 mRNA_TCEA3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null BRD-K22002184 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05131 hela cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.415814 CRCGN016_MCF10A.TP53.M_24H:L11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9597 BRD-K02329600 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6512 NCI-H650 COSMIC Cell Line Gene Mutation Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K56870772 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.20481 ZNF131 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.10833 TCF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.1831 CRCGN012_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.72315 HCC2911 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.51888 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A183-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KG1C CCLE Cell Line Gene Expression Profiles 1.0 1.67982 control GeneRIF Biological Term Annotations 1.0 null CRCGN013_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.28646 OVTOKO CCLE Cell Line Gene CNV Profiles -1.0 -1.51793 BRD-K73679670 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0739 CHAGOK1 CCLE Cell Line Gene Expression Profiles -1.0 -1.65706 bed nucleus of stria terminalis, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.21889 cervical carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.098188 INMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34581 CRCGN010_HEPG2_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.3676 GSC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95975 midline nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.990415 GSE200673,GSE200691_2_v_5_hmga2_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZFP69 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89684 BRD-K14216093 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26874 Leaf primordium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.952 PDAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25968 CRCGN015_HEPG2_48H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.09041 CYBA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64775 RIPPLY3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06532 KYSE150 CCLE Cell Line Gene CNV Profiles -1.0 -1.35687 BRD-K84935293 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11251 paraventricular nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.2959 ZNF25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56121 CRCGN015_MCF10A_48H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.11129 KYSE520 CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 Hmga1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.4952 TPM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25222 IQGAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53631 CD164L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04168 TestisIntersitial BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.927386 CRCGN011_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6815 mRNA_T_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null head TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K41382866 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.37799 Degeneration of macula and posterior pole DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.09 Lymphoma_burkitts(Raji) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.55362 HCC1897 CCLE Cell Line Gene CNV Profiles -1.0 -1.64095 IFI27L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96322 JSC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN015_MCF10A_48H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.16359 X Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.17209 abnormality of nervous system physiology GWASdb SNP-Phenotype Associations 1.0 0.052514 OTX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.6362 496100334_PCx_probable Alzheimer's disease_no TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.7804 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MN-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ME-180 GDSC Cell Line Gene Expression Profiles 1.0 1.59192 subgranular zone of rostral dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.886935 H3K4me1_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TMEM70 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.678 FOXA3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.2764 studies GeneRIF Biological Term Annotations 1.0 null CRCGN016_MCF10A.TP53.M_24H:L10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5938 COLO741 CCLE Cell Line Gene CNV Profiles -1.0 -1.6622 BRD-K16915521 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16683 Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.29 BRD-K10301055 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.53354 TBC1D25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76973 amygdaloid complex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.943052 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MMD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96343 HCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.919616 BRD-K39267096 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.33591 CRCGN015_HEPG2_48H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.81662 MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.837373 CRCGN011_HEPG2_24H:I20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6591 RASGRP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91374 CRCGN009_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.16634 BRD-K76539747 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.653 DDX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52068 HCC1954 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.868751 BRD-K03344897 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22906 HDAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52744 624 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.49063 primary auditory cortex (core)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.966567 BRD-K94062017 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00571 ZNF608 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99953 BRD-K46620987 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16758 A-375 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.964369 NCI-H1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.857794 BRD-K11741103 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16312 CHST6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53428 oa1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.519 TDGF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65078 Brain Lower Grade Glioma_LGG_TCGA-HT-A5RB-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ETV5::FOXO1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.2027 TNS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74201 GSE112860_3_v_4_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null KCTD20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83199 INKA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84452 RAD51B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82938 BRD-K67830713 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20946 BRD-A46317335 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69141 HCC1428 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.695313 MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18886 III, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.92327 CKS1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4759 GSE144838_1_v_5_egfr_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lens TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SETDB1-19884255-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null CAL-85-1 GDSC Cell Line Gene Expression Profiles 1.0 1.66034 GSE184884_4_v_1_gps2_mouse RummaGEO Gene Perturbation Signatures -1.0 null PKNOX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.4917 CRCGN010_HEPG2_24H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.04397 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19D-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7919-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K56783915 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24729 mRNA_EOMES_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null CLDND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.9804 LEDGF_KD_GDS1580_249_human_293T cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K96417480 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.28084 CRCGN014_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 9.094 FANCE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63727 CRCGN010_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.9618 paracentral lobule, anterior part, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.08564 COLO 741 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12418 NFIL3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.7249 CRCGN011_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.1936 RPMI7951 CCLE Cell Line Gene Expression Profiles -1.0 -1.73646 SAP30BP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41113 PRDM1 JASPAR Predicted Transcription Factor Targets 1.0 null animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CRCGN011_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.2531 MKN45 COSMIC Cell Line Gene Mutation Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051667 HAS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52291 H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MED6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42717 NRL_Deficiency_GDS1693_235_mouse_Photoreceptors cells of retinas at E16 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null NU-1025-313 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NR1I2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.1061 ZNF682 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81137 TEX15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.41595 GSE189683_1_v_2_rif1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CYFIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45773 Coloboma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.204 BRD-K53889798 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60808 NDUFA11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26757 GLB1L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88995 interstitial nucleus of Cajal, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.995748 ZNF140 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.5908 POU3F2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50465 ChIP_H3K9me3_19884255_mouseESC ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null sensory perception of light stimulus GO Biological Process Annotations 2015 1.0 null Nr2f6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 45.5403 GATA2_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K94790210 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3752 posteroventral (inferior) parietal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.55956 cortico-medial group, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.973172 CRCGN011_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.3864 ACBD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73878 EPHX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14487 M14 COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN008_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.69425 CRCGN011_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.024 GOT1L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77042 IV, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.16381 Blindness DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.17 FGFR3_knockdown_34_GDS4454 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.99485 MALSU1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77489 Scleral staphyloma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.32 NCIH2887 DepMap CRISPR Gene Dependency 1.0 2.19931 496100534_FWM_probable Alzheimer's disease_no TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.8562 SON_KD_GDS4448_35_human_HeLa GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K20745677 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12209 RUSF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62171 BRD-K02833343 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12149 CRCGN016_MCF10A.TP53.M_24H:P20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.32029 BRD-K61486072 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17312 E2F1_KD_GDS4094_446_mouse_Mammary tumors GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null ARMC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19684 BRD-K62415056 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10656 NECTIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50243 ZDHHC16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62019 GAK COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K05444553 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.79797 KYSE-450 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K47410882 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46731 NUPR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52993 BRD-K43982279 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.61265 RNASE4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37727 VZ in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.68018 REEP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05389 primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.58725 DMD_Deficiency_GDS2996_613_mouse_Cardiac muscles from 8-week (mdx animals) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Erg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 40.204 BRD-K02671211 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.32566 lateral subdivision of BNST Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.925519 BRD-K53458780 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.26646 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRD-K88626416 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00167 B4GALT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12086 biological_process GO Biological Process Annotations 2015 1.0 null MDAMB134VI Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.6715 LAPTM4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44904 EBF1-22473956-LYMPHODE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null TULP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17944 GRIK5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50535 BRD-K24727463 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16446 CRCGN015_HEPG2_48H:P13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.34951 BRD-K50212643 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.99382 Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DN-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CMYC-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K72083510 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06482 GATA2_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NPTXR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2339 NKX1-2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32713 BRD-K68086276 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03022 ventrolateral prefrontal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.83355 Genetic Predisposition to Disease HuGE Navigator Gene-Phenotype Associations 1.0 null ZKSCAN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52683 cell junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.084741 DYNC2I1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55305 BRD-K26620362 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35176 BRD-K50498614 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0886 CNOT6L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40383 TLX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4253 AK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.956 VI, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.837154 IV, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.65445 CRCGN015_HEPG2_48H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.24201 BRD-K77871059 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16716 BRD-K14098658 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.58177 CREB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58456 ME1 CCLE Cell Line Gene CNV Profiles -1.0 -2.21939 KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25386 BRD-K88498468 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.47568 CRCGN016_MCF10A.TP53.M_24H:N14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.7493 PELI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72011 MANEA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63006 SOX9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.8421 TP53 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.6608 CD19+_BCells(neg._sel.) BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.09357 SKHEP1 CCLE Cell Line Gene Expression Profiles -1.0 -1.88467 496100348_TCx_probable Alzheimer's disease_no TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.96137 Nervous system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.29 Heart BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.31354 LY2 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.2438 BRD-K01911039 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.79501 HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.39809 Eye degenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.084 BROX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52631 Brain cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.29 TMSB10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.94139 HS255T CCLE Cell Line Gene Expression Profiles -1.0 -1.62538 CRCGN017_MCF10A.WT.HP_24H:N02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8951 CRCGN011_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.8785 AVL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37888 CRCGN015_HEPG2_48H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.25202 Autosomal dominant disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.059 TK COSMIC Cell Line Gene Mutation Profiles 1.0 null CXXC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17286 CRCGN017_MCF10A.WT.HP_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.5021 ZBTB46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11342 KDM3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19628 C3A CCLE Cell Line Gene CNV Profiles 1.0 1.33927 G-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16658 IGFBP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01027 CCRT CEM BioGPS Cell Line Gene Expression Profiles -1.0 -1.32993 BRD-K75263760 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39117 SMIM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78483 BRD-K10505056 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54601 VIIIA Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.37704 BRD-K18958510 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09443 ventral posterior lateral nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.60757 HCC1500 CCLE Cell Line Gene CNV Profiles -1.0 -1.34576 TRIM16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01786 SMAD1-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null behavioral abnormality GWASdb SNP-Phenotype Associations 1.0 0.0875 CRCGN014_HEPG2_3H:F17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1075 PPP1R1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10454 BRD-K85059356 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35373 X, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.98581 MKI67 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72482 preoptic region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.34205 EMX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.1915 NCIH661 CCLE Cell Line Gene CNV Profiles 1.0 3.24313 BRD-K18149487 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.19966 TP53 ChEA Transcription Factor Targets 1.0 null BRD-K13646706 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44258 496100550_TCx_no dementia_TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.5697 GSR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14872 ALG12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87004 JHOM1 CCLE Cell Line Gene CNV Profiles -1.0 -1.41742 496100517_TCx_no dementia_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.10592 MLH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72213 BRD-K51600962 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.63916 GSE139966_1_v_2_figla_mouse RummaGEO Gene Perturbation Signatures 1.0 null JMJD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02154 CDX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3395 smoking cessation GAD Gene-Disease Associations 1.0 null inner SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.10572 GSE114553_0_v_1_lhx6_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF691 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42096 BRD-K89668690 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71095 ICC106 DepMap CRISPR Gene Dependency 1.0 4.49697 BRD-K28811650 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0548 BRD-K41620124 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04764 EGR1 ChEA Transcription Factor Targets 1.0 null QGP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.932606 HCC515 DepMap CRISPR Gene Dependency 1.0 2.44562 CRCGN015_HEPG2_48H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.75578 Gap junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.656 MIR222_KD_GDS4054_456_human_MCF7 breast cancer cells (fulvestrant-resistant) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null TOB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3018 VIIIB, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.15794 H3K27me3_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVCAR-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.66655 PRKCSH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78487 Brain Lower Grade Glioma_LGG_TCGA-WY-A85E-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KCI-MOH1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.902019 UNCX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.682 BRD-K41993678 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06752 C1GALT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36855 BRD-K69678391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00125 BRD-K61274359 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60981 BRD-K63197664 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03344 HMGA2_KO_GSE55340_21_mouse_lung (E18.5) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null ZNF157 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98424 H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K12665145 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.87271 DDX42 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37235 HT144 DepMap CRISPR Gene Dependency 1.0 2.8771 HSC3 CCLE Cell Line Gene Expression Profiles 1.0 1.80858 disease GWASdb SNP-Disease Associations 1.0 0.023767 GSE144838_4_v_3_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_HEPG2_48H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.35468 TFDP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59695 KLF4-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null all GWASdb SNP-Phenotype Associations 1.0 0.02812 BRD-K53489056 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06297 A172 DepMap CRISPR Gene Dependency 1.0 2.6059 H3C6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55374 HOXB9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.4078 Spleen GTEx Tissue Gene Expression Profiles 2023 1.0 1.06737 DGCR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51886 lens development in camera-type eye GO Biological Process Annotations 2015 1.0 null MDA MB435 BioGPS Cell Line Gene Expression Profiles 1.0 0.857017 SF172 CCLE Cell Line Gene Expression Profiles 1.0 1.68089 ARID5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77137 RALBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53416 magnocellular (medial) division of MD Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.36336 ZFP62 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46573 MRPS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63443 CFPAC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00234 G6PD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87404 GINS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58825 PCGF2-27294783-CHIP-SEQ-NPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PGRMC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65435 DUSP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08993 CRCGN012_HEPG2_24H:G02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.19496 KLC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73086 HCC1419 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.10658 Adrenal Gland Pheochromocytoma DisGeNET Gene-Disease Associations 1.0 null eye disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.692697 SULF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89262 IST-SL1 GDSC Cell Line Gene Expression Profiles 1.0 1.72255 DTD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82454 ChIP_SETDB1_19884255 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null 21NT DepMap CRISPR Gene Dependency 1.0 2.36028 SOCS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09541 EDF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39992 C2orf49 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.97212 COPS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15546 SOX6-21985497-MYOTUBES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null SLC38A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58192 GATA2 ENCODE Transcription Factor Targets 1.0 null Palisade parenchyma TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.633 CHAGOK1 CCLE Cell Line Gene CNV Profiles 1.0 1.63403 CRCGN015_HEPG2_48H:E13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.56364 primary motor cortex (area M1, area 4)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.29253 TENT4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07044 CRCGN017_MCF10A.WT.HP_24H:K22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.65045 VMRCRCZ CCLE Cell Line Gene CNV Profiles 1.0 1.98714 CDY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61273 COQ8B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48217 BRD-K09553491 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02937 CRCGN008_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5457 anteromedial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.917791 Lung adenocarcinoma_LUAD_TCGA-05-4382-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K53953065 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05108 Morgagni cataract DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.291 BRD-K33767317 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08666 CRCGN012_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.90601 ZFP28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32716 CRCGN015_MCF10A.WT.HP_24H:F09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.05886 sensory perception GO Biological Process Annotations 2015 1.0 null CRCGN013_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.90949 SG in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16376 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7424-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null sodium phenylbutyrate-407 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN009_HEPG2_24H:L07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.5205 HNRNPAB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.45198 RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02694 OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.964369 CRCGN012_HEPG2_24H:D09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.97937 CARHSP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21202 YAPC GDSC Cell Line Gene Expression Profiles -1.0 -1.79668 BRD-K23430114 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.91411 BRD-K94088690 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17398 BRD-K79355381 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59478 Posterior polar cataract DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.664 BRD-K25540102 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08666 CRCGN016_MCF10A.WT.HP_24H:P14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.28437 abnormal emotion/affect behavior GWASdb SNP-Phenotype Associations 1.0 0.259579 ILVBL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04153 BRD-K13436682 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30944 CRX-20693478-RETINA-MOUSE ChEA Transcription Factor Targets 2022 1.0 null FTC238 CCLE Cell Line Gene Expression Profiles -1.0 -2.32084 496100405_TCx_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.45317 BRD-K32124229 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00294 PER2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74954 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3MO-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K73166462 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6699 posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02542 BRD-K71194915 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4578 planum polare, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1915 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YH-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DUS1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52379 dorsalstriatum BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.08383 SETDB1 ChEA Transcription Factor Targets 1.0 null MDAMB436 DepMap CRISPR Gene Dependency 1.0 2.15277 MCF7 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.623977 Peripheral motor neuropathy_Sciatic Nerve_GSE1947 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.69445 CEP43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43455 H2BC18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38286 HTATSF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08915 cellular_component GO Cellular Component Annotations 2015 1.0 null BRD-K09598619 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 6.0364 ITGA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76541 inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.86194 medial vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.886398 liver BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.07371 GAPVD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42448 BRD-K07981644 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16674 cochlear nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.29135 CRCGN008_HEPG2_24H:I21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.39295 EXT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59982 CNOT6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43729 primary auditory cortex (core)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.23913 VIIAf Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.51642 primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.959464 CRCGN012_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.7844 cerebellar cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.947754 somatic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.531484 CRCGN017_MCF10A.WT.HP_24H:O14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4195 MYT1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89743 snoutepidermis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.08009 Petal TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.102 H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null HS695T DepMap CRISPR Gene Dependency 1.0 9.88339 HIC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51433 BRD-K51017127 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.86356 BRD-K07589203 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45077 pituitary BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.04626 H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K68303333 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18134 PFKFB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.36728 EYA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90822 orbital frontal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.858095 BRD-K46074482 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.60937 Beta/gamma crystallin InterPro Predicted Protein Domain Annotations 1.0 null External ectoderm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.345 H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF24 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.763 H3K4me1_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null cuneiform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.92188 ventral medial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12645 baseline GeneRIF Biological Term Annotations 1.0 null BRD-K87939000 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42634 CUX1 ENCODE Transcription Factor Targets 1.0 null BRD-K66807670 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10953 NCIH596 CCLE Cell Line Gene Expression Profiles -1.0 -2.38756 multicellular organismal process GO Biological Process Annotations 2015 1.0 null GSE200673,GSE200691_1_v_4_hmga2_mouse RummaGEO Gene Perturbation Signatures 1.0 null NEUROD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4669 SLC35B3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36895 UMC-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15402 CRCGN015_HEPG2_48H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.97037 IOMMLEE CCLE Cell Line Gene Expression Profiles 1.0 2.87386 H3K4me1_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1437 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02595 H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MAPK14_knockout_13_GDS2693 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.55416 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null SW620 BioGPS Cell Line Gene Expression Profiles -1.0 -0.829298 CRCGN016_MCF10A.TP53.M_24H:D15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.24668 UBXN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9156 case GeneRIF Biological Term Annotations 1.0 null MSX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.5209 TWIST1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22038 SHC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18303 AMOTL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01355 fulvestrant_homo sapiens_gpl570_gse22533 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K73088636 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18762 59M CCLE Cell Line Gene Expression Profiles -1.0 -1.93088 ZNF771 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84775 WDR89 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19429 BRD-K31372389 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07887 BRD-K86584551 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05047 ZBTB32 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50521 496100364_TCx_possible Alzheimer's disease_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.0543 GSE194268_2_v_0_pds5a_mouse RummaGEO Gene Perturbation Signatures -1.0 null H2AZ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71811 TE-11 GDSC Cell Line Gene Expression Profiles 1.0 3.60177 genetic GeneRIF Biological Term Annotations 1.0 null MARK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4655 KYSE-270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25386 NMB DepMap CRISPR Gene Dependency 1.0 4.71031 CRCGN014_HEPG2_24H:C01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.52086 MCM3AP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41451 BRD-K38111331 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41914 ATF6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15416 subparafascicular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.0712 MAGOHB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31833 TGIF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.5836 BRD-K25236390 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37245 ZNF764 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26413 FKBPL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37352 CISD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92349 LRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41948 endogenous depression GWASdb SNP-Disease Associations 1.0 0.539566 jf1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.598 BRD-K50127933 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48325 RNF24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60827 corpus callosum Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.82609 ZNF776 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.71584 Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A5W6-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dlx4_00000000_mcfdash7_gof_human_gpl201_gse21657 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.757695 cornea TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.487106 ATF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.0478 RAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6602 FMR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2158 H3K27me3_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR2F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6048 BRD-K04969760 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09539 Spore wall COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.441 SMC1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88292 Lung adenocarcinoma_LUAD_TCGA-75-5125-01A-01R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JN-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K68364310 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35838 globe disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.692296 CRCGN009_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 9.7859 HOXA6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.7385 CRCGN014_HEPG2_24H:N08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0945 NFXL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30766 HS766T CCLE Cell Line Gene Expression Profiles -1.0 -2.38259 PU1-27457419-CHIP-SEQ-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null FBXO45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51507 MYL6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53356 RAB11FIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97782 ventrolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.842526 CEBPZOS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45379 496100324_FWM_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.43586 NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18886 REH GDSC Cell Line Gene Expression Profiles 1.0 1.80368 MAFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19648 SW403 COSMIC Cell Line Gene Mutation Profiles 1.0 null Ribonuclease P complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.761 CRCGN011_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4926 BRD-K16698502 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51217 MSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.221 MOTN1 CCLE Cell Line Gene CNV Profiles 1.0 1.41196 MZT2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38439 BRD-K45519638 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52354 H3K27me3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null visual perception GO Biological Process Annotations 2025 1.0 null CRCGN017_MCF10A.TP53.M_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.2729 HMGN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05843 hippocampus (hippocampal formation)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.20317 CRCGN011_HEPG2_24H:H06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.14795 BRD-K23817660 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11629 NCI H226 BioGPS Cell Line Gene Expression Profiles 1.0 1.34733 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051422 CRCGN015_MCF10A.TP53.M_24H:J07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.36645 CRCGN009_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.07165 ZBTB7C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89965 Senescence_frontal cortex_GSE1572 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.85235 BRD-K34169251 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09451 Wolf-Hirschhorn syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.207 primary auditory cortex (core)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.71333 FOXA2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.5542 SPATA33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70486 BRD-K60080002 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09482 U343 CCLE Cell Line Gene Expression Profiles 1.0 2.04754 POLR2AphosphoS5_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mood disorder GWASdb SNP-Disease Associations 1.0 0.282564 BRD-K76135327 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59223 FZD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58912 nuclear cataract MGI Mouse Phenotype Associations 2023 1.0 null ZNF860 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78424 MRPS27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06858 BRD-K12524159 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36967 posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.836427 FOXJ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30651 ACTN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06893 MPP89 CCLE Cell Line Gene CNV Profiles -1.0 -1.61811 SG in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.825028 NEK8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93589 BRD-K90686530 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.57731 III, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.71724 CRCGN010_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.82685 A172 BioGPS Cell Line Gene Expression Profiles -1.0 -1.10652 CRCGN017_MCF10A.TP53.M_24H:K23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.3872 FLT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12507 HEPG2 CCLE Cell Line Gene CNV Profiles 1.0 1.33112 G-361 GDSC Cell Line Gene Expression Profiles 1.0 1.9626 RIMKLB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70275 hippocampus (hippocampal formation)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.864646 uterine cervix TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.301398 ZNF155 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07716 TMEM169 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88272 EW-18 GDSC Cell Line Gene Expression Profiles 1.0 1.99746 ZFHX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89328 FOXP4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.208 PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-fromNode_SOX4 Rummagene Transcription Factor Associations 2026 1.0 null changes GeneRIF Biological Term Annotations 1.0 null P2RX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83389 BRD-K97368902 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18973 primary auditory cortex (core)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.13123 Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.716 CRCGN017_MCF10A.WT.HP_24H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.25366 SS18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.26742 vacuolated lens MGI Mouse Phenotype Associations 2023 1.0 null NHLRC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46728 CGREF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92742 H3K27me3_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_HEPG2_48H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.28734 Prdm5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.6378 CRCGN012_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8669 CBFA2T2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12118 Porencephaly DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.448 BHY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.964369 Glaucoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.562 BRD-K87743988 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.89168 Optic cup TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.192 CLCN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26183 Fruit capsule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.892 BRD-K56428170 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.50071 MCAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19022 SOX2-27498859-CHIP-SEQ-STOMACH-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CRCGN013_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.32715 Brain Lower Grade Glioma_LGG_TCGA-HT-A4DS-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VMRCRCW CCLE Cell Line Gene Expression Profiles 1.0 1.60939 PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7--Target_name_PAX7 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K01667746 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08474 HS751T CCLE Cell Line Gene Expression Profiles -1.0 -1.83468 BRD-K64194889 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34407 GSE127790_13_v_3_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN011_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.6129 ATP8B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61696 BRD-K41410736 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.2081 BRD-K76415725 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21933 CBX7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87273 OXCT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67987 MEF2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.0421 agerelated GeneRIF Biological Term Annotations 1.0 null Obesity_Muscle - Striated (Skeletal) (MMHCC)_GSE5109 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 0.940862 NCI-H889 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.964369 BRD-K86746660 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.87443 BRD-K29469525 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30864 CLASP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81809 Neurological pain disorder_Dorsal Root Ganglia_GSE15041 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.27478 BRD-K99221119 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.66658 FU97 COSMIC Cell Line Gene Mutation Profiles 1.0 null DNAAF9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93347 lens TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.779401 Lens cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.212 FAM72B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76769 Cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.29 RHOXF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37079 facial motor nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.959337 SG in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.37786 establishes GeneRIF Biological Term Annotations 1.0 null RAB24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50917 BRD-K52973286 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01597 ZNF770 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52011 MOGGCCM CCLE Cell Line Gene CNV Profiles -1.0 -1.362 epithelioma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05199 visual perception GO Biological Process Annotations 2023 1.0 null IFI16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87871 PARK7_KD_GDS3750_2_human_SH-SY5Y GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null CRCGN014_HEPG2_3H:N09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.60119 CRCGN009_HEPG2_24H:H02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.15029 DCUN1D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76639 disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042743 697 GDSC Cell Line Gene Expression Profiles 1.0 1.84654 BRD-K82781769 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43927 SP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.1685 CTCF ENCODE Transcription Factor Targets 1.0 null Psoriasis vulgaris_Skin tissue_GSE14905 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 3.64541 Hyperplasia CTD Gene-Disease Associations 1.0 1.35849 disease of mental health GWASdb SNP-Disease Associations 1.0 0.041734 EZH2-27294783-CHIP-SEQ-NPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K43680691 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05395 Vitreous chamber of the eye TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.131 FOXS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.016 CRCGN016_MCF10A.WT.HP_24H:O24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.43545 integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050605 Central nervous system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.29 BRD-K84846130 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42756 ARFGEF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18218 TSNAX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8543 sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.668345 SUM159PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.923775 KASUMI1 CCLE Cell Line Gene CNV Profiles -1.0 -1.93324 CRCGN013_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.66385 CRCGN016_MCF10A.WT.HP_24H:M01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.00128 ZNF415 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93936 VEGFA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47288 BRD-K07861364 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.23565 S-isopropylisothiourea LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.75821 ventral anterior nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.12601 Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.357 BRD-K49577636 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15044 ruptured lens capsule MPO Gene-Phenotype Associations 1.0 null RAG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2346 BRD-K29260599 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.06648 Neural retina TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.879 probucol_mus musculus_gpl9523_gds3616 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PCDHB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17975 ALK_KD_GDS2724_105_human_DAOY medulloblastoma cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null SNU81 CCLE Cell Line Gene Expression Profiles -1.0 -3.10636 SLC39A13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40268 SNU478 DepMap CRISPR Gene Dependency 1.0 2.60315 WB-4101 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.8349 L540 CCLE Cell Line Gene CNV Profiles 1.0 1.4864 Squamous cell carcinoma_Lung Tissue_GSE1987 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -0.55873 CRCGN013_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.6374 EFO-21 GDSC Cell Line Gene Expression Profiles -1.0 -1.68336 upper limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.36943 HDQP1 CCLE Cell Line Gene CNV Profiles -1.0 -2.41859 BRD-K10385824 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.77096 TLX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.2522 METTL16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72314 NARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60528 RIMS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30722 DMS 79 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.835114 V, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.00677 BRD-K76966915 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24037 RAX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.3196 Prostate adenocarcinoma_PRAD_TCGA-KK-A7B3-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null developmental process GO Biological Process Annotations 2015 1.0 null BRD-K53356402 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05245 PRRX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.6676 SGPP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21202 Myopia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.523 Cornea TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.649 orbital frontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.07298 JURLMK1 CCLE Cell Line Gene Expression Profiles -1.0 -1.47198 TOP3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22237 CRCGN008_HEPG2_24H:G16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8016 TIMM17B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88712 BRD-K92144896 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2155 CRCGN014_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.01355 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5201-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K88179337 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35796 CRCGN017_MCF10A.WT.HP_24H:E04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.7259 ZNF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12538 TMEM44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83848 C1orf116 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82576 structural constituent of eye lens GO Molecular Function Annotations 2015 1.0 null Esrrg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.8247 RB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40629 BRD-K66061243 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21659 NFE2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.9207 SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.8784 NCI-H460 GDSC Cell Line Gene Expression Profiles 1.0 1.83248 CRCGN015_MCF10A_48H:J16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.6228 abnormal lens morphology MPO Gene-Phenotype Associations 1.0 null total cataracts MPO Gene-Phenotype Associations 1.0 null GPR62 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22346 V Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.2008 ventrolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.02057 Eye accommodation disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.172 FOXP2 ChEA Transcription Factor Targets 1.0 null TXN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75591 MS751 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.78357 NR1D2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.5417 subgranular zone of caudal dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15228 VMRC-LCD Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15284 Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K16641781 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56416 PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Down_bins-Down_bins_loosing_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4351-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nance-Horan syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.381 MYOG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.1382 Arntl JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.4866 BICR31 CCLE Cell Line Gene Expression Profiles -1.0 -1.68951 epithelial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053256 JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.6451 LDB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27646 BRD-K18558473 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07282 BRD-K92581247 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70632 BRD-K17416171 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04509 BRD-K43918582 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21234 Thyroid BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.892331 Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.23 CSRNP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99177 SW948 CCLE Cell Line Gene CNV Profiles 1.0 1.33927 RD CCLE Cell Line Gene CNV Profiles 1.0 2.39161 CRCGN014_HEPG2_24H:L18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.42759 primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.39498 Myofibrillar myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.059 PCDHB16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50949 BRD-K35407043 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22146 cervical adenocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.134466 SW 1417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34852 MEOX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.0063 TRAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12982 CRCGN015_HEPG2_48H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.08578 dorsolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.03128 SUDHL5 DepMap CRISPR Gene Dependency 1.0 3.31497 BRD-K57502201 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3349 CRCGN014_HEPG2_24H:F17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.42049 BRD-K85917058 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11869 anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.19106 HINFP JASPAR Predicted Transcription Factor Targets 1.0 null SUZ12-27294783-CHIP-SEQ-NPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null cortico-medial group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.54453 PPCS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89705 SG in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08901 BRD-K68365891 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26773 SLC17A5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11859 496100351_FWM_no dementia_TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.83732 CSAD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86409 OPA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53061 Brain Lower Grade Glioma_LGG_TCGA-HT-A61C-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OVCAR8 CCLE Cell Line Gene CNV Profiles -1.0 -2.45678 ABRAXAS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65552 cell property TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.245491 ventrolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.23568 Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A40U-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K62170825 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37595 Perturb_15774_KO_Uxt_SRP240277 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 16.8345 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PLEKHG4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11155 JL1 CCLE Cell Line Gene CNV Profiles 1.0 1.46515 FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null KMT2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51715 LEUTX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78984 CRCGN014_HEPG2_24H:N09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.30578 H3K27me3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLVL DepMap CRISPR Gene Dependency 1.0 2.51283 docebenone LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.02438 GlobusPallidus BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.20855 Brain Lower Grade Glioma_LGG_TCGA-DU-6392-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K55869732 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12775 BRD-K01367715 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15915 CDC42BPG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81017 paraventricular nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.47812 BRD-K31721388 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17128 CRCGN009_HEPG2_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.31913 CRCGN008_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 10.0 posterior hypothalamic area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.26809 P2RX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7402 H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.22113 BCAR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62999 single-multicellular organism process GO Biological Process Annotations 2015 1.0 null Congenital Cataract DisGeNET Gene-Disease Associations 1.0 null BRD-K63909265 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26942 MFE296 DepMap CRISPR Gene Dependency 1.0 2.83747 BRD-K45328741 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20838 HCC1263 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.919616 AP3D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65996 SEC61A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81406 IRF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.0605 SNG-M COSMIC Cell Line Gene Mutation Profiles 1.0 null SG in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.892609 UGGT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99951 BRD-K10471793 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.44769 CHP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32481 Ayme-Gripp syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.222 CRCGN014_HEPG2_3H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.76775 CTCF-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null ETV5::DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.6101 SNU-449 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.897801 AMO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.33316 CRCGN013_HEPG2_24H:B07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.51246 four GeneRIF Biological Term Annotations 1.0 null BRD-K68985225 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08401 NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18886 BRD-K12396271 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.72031 CHST2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65147 LCN12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03545 GOLIM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5978 occipital pole, left, lateral aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.22324 BRD-K15236933 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25539 Lung adenocarcinoma_LUAD_TCGA-55-8299-01A-11R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K57833824 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2557 Lung squamous cell carcinoma_LUSC_TCGA-85-7950-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K95651150 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.50378 SETD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.97153 CUX1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA1 ENCODE Transcription Factor Targets 1.0 null COLO 679 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.932606 FADU CCLE Cell Line Gene Expression Profiles 1.0 1.40067 SNX7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69649 H3K27me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null LIMD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63797 BRD-K14359826 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50941 Elf5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.1527 T-47D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02694 primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.4367 ACSF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.096 FAU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03947 Brain Lower Grade Glioma_LGG_TCGA-S9-A6WG-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cataract DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.796 TBXT JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.7977 NO11 DepMap CRISPR Gene Dependency 1.0 4.09753 c16 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.554 TASK1 COSMIC Cell Line Gene Mutation Profiles 1.0 null RS11846 BioGPS Cell Line Gene Expression Profiles 1.0 0.857017 ATG101 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39016 CRCGN009_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.2212 ECD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5192 496100653_PCx_probable Alzheimer's disease_no TBI_82_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.33977 Skin - Not Sun Exposed (Suprapubic) GTEx Tissue Gene Expression Profiles 2023 1.0 3.08975 HOXA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57349 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DH-5140-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LOVO COSMIC Cell Line Gene Mutation Profiles 1.0 null B3GNT8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56531 olfactory tubercle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.87587 SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.43609 CRCGN015_HEPG2_48H:J17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.05713 GSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.2002 GSE171401_1_v_0_adnp_mouse RummaGEO Gene Perturbation Signatures 1.0 null PNPLA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01115 MTERF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07512 Uveal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.335 BRD-K35760166 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.28538 FOXE1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 60.4762 BRD-K34913101 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12485 Sepal TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.749 total cataract MGI Mouse Phenotype Associations 2023 1.0 null CRCGN015_HEPG2_48H:H01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.77988 primary auditory cortex (core)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.69398 mainolfactoryepithelium.MOE. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.851474 CRCGN015_MCF10A_48H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.57085 PMC10204296-13578_2023_1034_MOESM16_ESM.xlsx-Black-ZNF671_ZNF671 Rummagene Transcription Factor Associations 2026 1.0 null MDA-MB-231 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.964369 BRD-K86677819 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14605 ZNF141 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.11876 FJX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3531 ventral posterior inferior nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00488 CRCGN017_MCF10A.WT.HP_24H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.83045 KCTD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.02287 hippocampus (hippocampal formation)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.906048 BRD-K86937728 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6698 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.47557 CRCGN015_MCF10A_48H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.2078 CRCGN015_MCF10A.WT.HP_24H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.3112 METTL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18415 BRD-K91467861 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57444 JKAMP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35113 BRD-K43820045 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48771 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4217-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SUM52PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.73139 BRD-K63579322 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55241 RERFLCAI CCLE Cell Line Gene CNV Profiles 1.0 1.57123 REL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.8235 NOC2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1008 COLO 857 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22882 H3K4me1_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K77697725 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48874 KCNK6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5931