association	dataset	threshold value	standardized value
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.12066
membrane	LOCATE Curated Protein Localization Annotations	1.0	null
lipomatous cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.232836
8903_TIAL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.893521
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.964393
epitopes	GeneRIF Biological Term Annotations	1.0	null
BRD-K60623809_SU11652_SNU1040_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
melanocyte	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC9075502-crc-21-0022-s07.xlsx-WT_IgM_vs_KD_IgM-Unnamed_0_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MYO18A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34277
GP5D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
treatment	GeneRIF Biological Term Annotations	1.0	null
ZNF324B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38162
BRD-K03304013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04452
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZQ-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
salivary gland carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.143265
neoplasms; stomach neoplasms	GAD Gene-Disease Associations	1.0	null
liver	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Seminoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.262
BRD-K76400756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06116
4540_LDB1_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.582664
CAL-85-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0399
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.996292
GSE154936_3_v_2_remdesivir_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K88119862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02168
non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.486
vitamin c_mus musculus_gpl6246_gse32994	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K45057266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.07856
SK-N-AS	GDSC Cell Line Gene Expression Profiles	1.0	1.51543
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4759-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NK-A5CR-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K64567246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95219
Lung squamous cell carcinoma_LUSC_TCGA-34-5240-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K07870648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21693
SNAI2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1786
DorsalRootGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.888101
cardiovascular cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.237357
ROS50	DepMap CRISPR Gene Dependency	1.0	8.0479
A3KAW	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41811
EW-24	GDSC Cell Line Gene Expression Profiles	-1.0	-2.04431
H3K27me3_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle part	LOCATE Curated Protein Localization Annotations	1.0	null
NRAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01107
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
lymph node	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.387027
BRD-K49005954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52123
cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.227752
RAD23B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77434
10803_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.599095
GSE201309_1_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DV90	CCLE Cell Line Gene Expression Profiles	1.0	1.69917
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	80.2987
GSE216757_4_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
multiple myeloma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.55712
fetus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRELD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49323
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.791
SCC-15 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.005
IGR1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.36107
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
klf10	GeneRIF Biological Term Annotations	1.0	null
BRD-K97307478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56753
Bloch-Sulzberger syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
CEBPZ_02_05	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.6173
PPP3R1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11573
heart valve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.115027
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2M5-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDAMB415	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.687599
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.414
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.438
FAM117A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42889
4939_MED17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.561523
epithelial	GeneRIF Biological Term Annotations	1.0	null
antinyeso1	GeneRIF Biological Term Annotations	1.0	null
Mesothelioma_MESO_TCGA-MQ-A6BS-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
placenta	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.399492
CCNY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02165
b-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.11002
Muscle cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.242
59M	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47514
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IX-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Fetal Brain Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.847326
IRF2BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21002
RBFOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79902
B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.369
esophagus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.691676
respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.429266
gametocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.09098
BRD-K76922696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31676
Hodgkin's lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.08
Sarcoma_SARC_TCGA-DX-A6B8-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_1h-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K69932463_AZD-8055_HS578T_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6246
BRD-K07365255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25001
Pituitary cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
SKBR3	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.953494
tRNA threonylcarbamoyladenosine metabolic process	GO Biological Process Annotations 2023	1.0	null
Melanoma cell line	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HT-55	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.92855
4957_MED7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.662235
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
significant	GeneRIF Biological Term Annotations	1.0	null
following	GeneRIF Biological Term Annotations	1.0	null
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.34134
4363_VIRMA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.543355
mp10	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.955
Large B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.22
BRD-K21680192_mitoxantrone_PC3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
paraventricular nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.7631
6963_PWP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.555604
CBX2-27304074-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.560478
KMT2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96041
ABCA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95994
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
IZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.93437
HGC27	CCLE Cell Line Gene Expression Profiles	1.0	2.25954
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.02206
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6022-01A-21R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.16
ZSCAN22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79973
ZNF365	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67613
20368555-TS-1	GeneSigDB Published Gene Signatures	1.0	null
HIF3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09506
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MTF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61078
BRD-K90048234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29353
ZNF200	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56968
external granular (germinal) layer of lower rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.71558
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.677
OVCAR8	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.876648
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41O-01A-12R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MTF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.2167
NCIH1651	CCLE Cell Line Gene CNV Profiles	-1.0	-1.72192
non-small cell lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.339806
BRD-K22447639	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32704
KMCH cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.543
cutaneous t cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.403811
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
lsamp	GeneRIF Biological Term Annotations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A66S-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
adenocarcinoma	GeneRIF Biological Term Annotations	1.0	null
SNU216	DepMap CRISPR Gene Dependency	1.0	2.04707
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.5236
NCIH2227	CCLE Cell Line Gene CNV Profiles	-1.0	-1.81591
MEL-745A cl. DS19 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.541
ZNF782	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18185
SG in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.827635
ct96	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.776
8126_SLU7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.597428
SP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.852464
Perturb_8355_KO_ZCCHC4_SRP345783	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.06052
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
sarcomere	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.484483
GSE163240_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RH18	CCLE Cell Line Gene Expression Profiles	-1.0	-2.35496
labetalol-3167	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K71155312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00915
GSE226770_1_v_6_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210101,GSE210114_0_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100365_HIP_probable Alzheimer's disease_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.63638
BRD-K36278687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53999
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.435
BRD-K32862383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11335
FAM3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59431
soft body part	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.237513
BRD-K03035008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50083
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Red blood cell traits	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.83979
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-375 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.942
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
20208059-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	107.178
salivary gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.119819
BRD-K73227539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48762
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	93.2659
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TRIL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92216
Musculoskeletal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.711
stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.074309
AMIGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07751
LETM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03235
Lung adenocarcinoma_LUAD_TCGA-55-1594-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZFP37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48938
GSU	DepMap CRISPR Gene Dependency	1.0	6.23513
Leiomyosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.192
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.567
isolation	GeneRIF Biological Term Annotations	1.0	null
chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.112687
graft-versus-host disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.3
BRD-K76588804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29399
GSE236486_1_v_0_arnt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5136
BRD-A59985574_T542500_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.105567
proliferation	GeneRIF Biological Term Annotations	1.0	null
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04856
Lung adenocarcinoma_LUAD_TCGA-86-7711-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nucleus	LOCATE Predicted Protein Localization Annotations	1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FBXO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98298
ITFG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46308
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.970173
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JD-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K08009212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58936
GSE202434,GSE202438_12_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
15161681-Table1	GeneSigDB Published Gene Signatures	1.0	null
Myxoid liposarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.792
Adrenocortical carcinoma_ACC_TCGA-OR-A5KV-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A89337244_-666_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K49328571_dasatinib_MCF7_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-A56V-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
epithelium	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.918162
hsa-miR-495	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
10856_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-1.04158
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M9-01A-23R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.978571
esophageal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.296013
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.551
GATA3-21867929-TH1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.902842
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MY-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE130396_0_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE221327_10_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
645_ATP1A1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.516741
inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20405
BRD-K39013648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05621
correlations	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TCTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87351
HCC1428	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.89716
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.17259
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23703
melanoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.295297
paclitaxel_homo sapiens_gpl570_gse11552	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DCA_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
GSE115364_0_v_1_idh3a_human	RummaGEO Gene Perturbation Signatures	1.0	null
6792_PRPF19_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.503551
norfloxacin-7283	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ING4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66328
cannot	GeneRIF Biological Term Annotations	1.0	null
SNU182	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35211
GSE96777,GSE96778_3_v_2_zbtb4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
LMO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06828
Skin Cutaneous Melanoma_SKCM_TCGA-GF-A6C8-06A-12R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K89584810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06283
BRD-K02093145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67899
GSE221327_5_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ejg	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.674
prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.187719
GSE95077_5_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.69179
BRD-K56408846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71873
Squamous papillomatosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.259
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.69333
BRD-K97938633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02809
acenocoumarol-7232	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE218727_0_v_1_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K90284572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38843
BRD-K01211710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02261
GCIY	CCLE Cell Line Gene Expression Profiles	1.0	1.72843
BRD-K08389897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03699
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.6342
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040327
Ovary epithelial cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.416
BRD-K18763924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91193
2324_DOCK6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.91448
Lung adenocarcinoma_LUAD_TCGA-44-7660-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE221327_8_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
4935_MED14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.508745
stratum radiatum of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.34234
Lung squamous cell carcinoma_LUSC_TCGA-90-A4ED-01A-31R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CYRIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49589
GSE213588_8_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70894
BRD-A70931301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25175
BRD-K60692685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09346
Lung squamous cell carcinoma_LUSC_TCGA-43-8118-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.902308
Bone cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.225
ZNF454	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	158.963
HUH1	CCLE Cell Line Gene Expression Profiles	1.0	1.35255
SNU-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.92855
HT-1080	GDSC Cell Line Gene Expression Profiles	1.0	2.15805
tumorspecific	GeneRIF Biological Term Annotations	1.0	null
immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.360764
BRD-K74663731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7669
Bone sarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.291
MSLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63673
patient	GeneRIF Biological Term Annotations	1.0	null
peptides	GeneRIF Biological Term Annotations	1.0	null
E2F6	JASPAR Predicted Transcription Factor Targets	1.0	null
DCAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56477
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
mature t-cell and nk-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.263368
BRD-K60861723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08376
SUM52PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.83217
WM88	CCLE Cell Line Gene Expression Profiles	1.0	1.87799
GSE238018_3_v_0_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MYCN-21190229-SHEP-21N-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Testis	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.95262
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.449
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EJ-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
future	GeneRIF Biological Term Annotations	1.0	null
4470_KRI1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.539801
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M6-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.065117
BRD-K38997615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78022
IGR1	DepMap CRISPR Gene Dependency	1.0	2.05818
PMC7176284-pcbi.1007753.s008.xlsx-2_MYCN-NA_NBL_Multimodal_Genes-gene_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-V1-A8X3-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NPrEC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.801
Esophageal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.008
HIST1H4F	Pathway Commons Protein-Protein Interactions	1.0	null
Sarcoma_SARC_TCGA-DX-A8BK-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ovarian Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
RELB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2343
SP in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.49964
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.82361
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.910276
COLO849	CCLE Cell Line Gene Expression Profiles	1.0	1.38309
Lung squamous cell carcinoma_LUSC_TCGA-60-2723-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF627	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00893
TE8	CCLE Cell Line Gene Expression Profiles	-1.0	-2.82614
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.7133
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
ZNF469	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9927
GSE48812_0_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K27754030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38252
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A49A-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN011_HEPG2_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40938
GSE178714_6_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
HT1080	BioGPS Cell Line Gene Expression Profiles	1.0	1.63619
CRCGN016_MCF10A.WT.HP_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32336
SU8686	COSMIC Cell Line Gene Mutation Profiles	1.0	null
t-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.780648
Gonad	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.54
Lung squamous cell carcinoma_LUSC_TCGA-77-8143-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ferulic-acid	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2881
SGPL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00444016
6850_PSMB2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.523229
liver cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A361	BioGPS Cell Line Gene Expression Profiles	1.0	1.45222
plasma cell neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.141181
SSB_02_164	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.58748
D341Med	DepMap CRISPR Gene Dependency	1.0	2.03784
anterior (rostral) cingulate (medial prefrontal) cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.913038
SW1783	COSMIC Cell Line Gene Mutation Profiles	1.0	null
11294_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.578612
endopiriform nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.979945
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
microvascular endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.101578
SP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.968886
BRD-K70511574_sunitinib_MCF7_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.478145
Lung adenocarcinoma_LUAD_TCGA-78-7155-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K17209411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37255
Alzheimer's disease 8	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.199
Esophageal epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.637
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.064
Proteasome regulatory particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.574
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NR-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SV2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83334
Sec61 translocon complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.696
posteroventral (inferior) parietal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.28906
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100491_HIP_no dementia_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04047
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.922299
BRD-K49995660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72571
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.78588
Sarcoma_SARC_TCGA-Z4-A9VC-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
sera	GeneRIF Biological Term Annotations	1.0	null
HCC1359	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49611
microtubule cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
T47D	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.09143
endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.071127
lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.718292
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
SW579	CCLE Cell Line Gene CNV Profiles	1.0	1.32802
CRCGN015_HEPG2_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.33029
BRD-K69238239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1555
wide	GeneRIF Biological Term Annotations	1.0	null
ventrolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.56843
Sarcoma_SARC_TCGA-PC-A5DM-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
medial subdivision of central nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.874447
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5365-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JAR	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K64992851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2238
GBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00526994
6874_PSMD6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.539632
striatum_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14088
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.053807
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE163884_1_v_0_sumo2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00745
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.11551
BRD-K77787814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02507
1921_CTAG2_ENST00000369585.3	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.634926
MRPL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5755
striatum_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.976937
BRD-K27914478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0289
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T0-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135030_11_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.88902
Lung squamous cell carcinoma_LUSC_TCGA-33-A4WN-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterine lavage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.856
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27217
GSE135030_11_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
immunotherapy	GeneRIF Biological Term Annotations	1.0	null
GSE216757_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K31215362	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04541
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
9505BIK	DepMap CRISPR Gene Dependency	1.0	4.06025
ACP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85563
plasmacytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.218374
PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
TF1	CCLE Cell Line Gene CNV Profiles	1.0	1.93509
connective tissue cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.064782
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.25355
BRD-A19037878_trichostatin A_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Chondrosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.25
BRD-K59099886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57897
ifenprodil-5044	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K71460915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.042
RFXANK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37208
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.1679
C6orf141	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80187
ARHGEF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45699
9747_VPS28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.553814
hippocampus (hippocampal formation)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03614
LB2518-MEL	GDSC Cell Line Gene Expression Profiles	-1.0	-1.93255
HCC827	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.840144
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.575305
integumentary system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.1936
organelle part	GO Cellular Component Annotations 2015	1.0	null
GSE153871_4_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K23204256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07474
NCCRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95105
BRD-K57026098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77508
MDAMB453	DepMap CRISPR Gene Dependency	1.0	4.34498
GLI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42927
Mean corpuscular hemoglobin	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.8699
PARP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60652
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052632
BRD-K72430479	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13399
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.859677
HCC1599	CCLE Cell Line Gene CNV Profiles	1.0	1.49951
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5709-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SKMES1	CCLE Cell Line Gene CNV Profiles	1.0	2.02063
pancreatic carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.387423
cytoskeletal part	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K27058632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.39258
MORF4L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34164
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01254
SW837	COSMIC Cell Line Gene CNV Profiles	1.0	3.12177
BRD-K62612761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20866
PK45H	CCLE Cell Line Gene CNV Profiles	1.0	1.82055
19204204-SupplementaryTable1	GeneSigDB Published Gene Signatures	1.0	null
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	230.439
ventral posterior medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02496
primary auditory cortex (core)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.78504
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3WC-01A-31R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
prame	GeneRIF Biological Term Annotations	1.0	null
endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059317
orf2	GeneRIF Biological Term Annotations	1.0	null
BT474	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68205
AR-27623747-22RV1-MOUSE-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
myofibril	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.428284
SCC4	CCLE Cell Line Gene CNV Profiles	1.0	2.36918
CD163	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00546976
BRD-K55895855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28686
4613_LMBRD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-1.07673
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K84836394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11634
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SG-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
U266B1	CCLE Cell Line Gene Expression Profiles	1.0	2.06048
PRKAR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80875
BRD-K55606442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78157
Perturb_2126_KO_SUMO1_SRP299611	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
ventrolateral prefrontal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.874744
eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040759
intracellular non-membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
posteroventral (inferior) parietal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.990781
MYC_KD_GSE22139_685_human_medulloblastoma	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K14671528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36761
ventrolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.26953
GLYR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46262
GSE202434,GSE202438_8_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51E-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.04598
TE5	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53304
BRD-K69808609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17275
spectrum	GeneRIF Biological Term Annotations	1.0	null
HES7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.544
amygdaloid complex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.41893
BRD-K06724886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00277
CRCGN015_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3569
TNFRSF6B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00408011
Esophageal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.268
Vastus medialis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.712
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14251
ZBTB7C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.296
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.55
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.927619
SKNDZ	DepMap CRISPR Gene Dependency	1.0	2.96594
Spermatogonium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.318
Acute Myeloid Leukemia_LAML_TCGA-AB-2867-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
vascular cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.261952
BRD-K58644442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51248
NCI-H1355	GDSC Cell Line Gene Expression Profiles	-1.0	-1.6716
BRD-K19390761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0134
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.062
CRCGN015_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3563
BRD-K21771537	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13954
4950_MED27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.905732
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.25756
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Head	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.141
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040896
Lung squamous cell carcinoma_LUSC_TCGA-58-8387-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.191
support	GeneRIF Biological Term Annotations	1.0	null
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
SK-MEL-23 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.896
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HNF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36517
BRD-K76734722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32539
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.926279
BRD-K96491043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71863
BRD-K78015078	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20253
Malignant exocrine pancreas neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
primary auditory cortex (core)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.997888
CEBPE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47669
chlorambucil-3788	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
thelper	GeneRIF Biological Term Annotations	1.0	null
BRD-K03715233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0636
BRD-K99074976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12013
cytoskeletal part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE188570,GSE188571_3_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
RAX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12917
6801_PRPF4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.677205
cytoskeletal part	GO Cellular Component Annotations 2015	1.0	null
peripheral blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.347408
6460_PLRG1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.668669
RCC10RGB	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Esophageal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.064
GCSH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53504
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3B6-01A-21R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUM229PE	DepMap CRISPR Gene Dependency	1.0	5.78231
inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.7165
BMF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00581987
Brain Lower Grade Glioma_LGG_TCGA-QH-A6XC-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K72238567_656402-250MG_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.3228
H3K79me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K31204557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3726
BRD-A68797623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54154
SELENOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8321
lytic vacuole	LOCATE Predicted Protein Localization Annotations	1.0	null
dermal microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.267791
EB1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.81574
RD	COSMIC Cell Line Gene Mutation Profiles	1.0	null
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.563604
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A6HN-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053425
amrinone-2724	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NUP58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07763
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.59
NPEPPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85424
RMGI	CCLE Cell Line Gene CNV Profiles	1.0	1.37854
GSE135030_3_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K61796560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07353
MYCN	ChEA Transcription Factor Targets	1.0	null
esophageal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.099355
Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F1-01A-11R-A034-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EEF1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2911
ZNF135	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	121.301
ovarian	GeneRIF Biological Term Annotations	1.0	null
PMC12500934-41408_2025_1358_MOESM3_ESM.xlsx-Table_S6-DEGs_p_0_05_between_surviving_or_deceased_DLBCL_patients_that_received_R-CHOP_therapy_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.1585
639-V	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Acute myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.294053
GSE238018_3_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K57315740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42822
MZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.993798
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10117
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.553
BRD-K56653679_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K31992830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49036
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MERO83	DepMap CRISPR Gene Dependency	1.0	3.02096
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A729-06A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K54042694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89154
BRD-K91490997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7877
MDAMB415	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
GSE221327_10_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9424213-41467_2022_32537_MOESM5_ESM.xlsx-HeLa_IER3sh_DEGs-DEGs_in_HeLa_IER3sh_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Male reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.372
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.42102
SW48	COSMIC Cell Line Gene Mutation Profiles	1.0	null
4152_INTS7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.536166
GSE206516,GSE206518_2_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
G361	CCLE Cell Line Gene Expression Profiles	1.0	1.5109
myopia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.185612
PHF8	ENCODE Transcription Factor Targets	1.0	null
GSE110802_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2120_DDX41_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.635286
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.673
KMS21BM	CCLE Cell Line Gene Expression Profiles	1.0	1.59893
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.929173
T-cell non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
ZSCAN21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72328
GSE223893_2_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ANKRD23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27075
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.311
serum	GeneRIF Biological Term Annotations	1.0	null
10244_ZNF260_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.50927
9475_U2SURP_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.514083
19204204-SupplementaryTable5	GeneSigDB Published Gene Signatures	1.0	null
GSE221327_6_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.67916
BRD-K30312557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18355
cdna	GeneRIF Biological Term Annotations	1.0	null
SOX5	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K91506006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50835
ZNF682	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	77.966
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053396
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.231
stratum lacunosum-moleculare of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.65363
NCI-H1299	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.896382
epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065787
GSE221327_4_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
rostral division of OFCi (area 11)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.993717
male reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.556
BRD-K73109821_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-US-A774-01A-21R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DPY19L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53082
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9RC-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K73075421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59135
AU565	CCLE Cell Line Gene CNV Profiles	-1.0	-1.94072
BRD-K05118861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0022
2251_DMAP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.526324
SCAF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93853
hepatocellular	GeneRIF Biological Term Annotations	1.0	null
SHARPIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50295
BRD-K76885311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1835
BRD-K94766933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74297
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70G-01B-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TEN	DepMap CRISPR Gene Dependency	1.0	2.97602
19525976-SuppTable5b	GeneSigDB Published Gene Signatures	1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.323
1197_CARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.799002
HIF1A_DEPLETION_GDS2760_642_human_Hypoxic MCF-7 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
KMS18	DepMap CRISPR Gene Dependency	1.0	2.71592
Esophageal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.771
one	GeneRIF Biological Term Annotations	1.0	null
anteromedial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.843158
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01254
intracellular part	GO Cellular Component Annotations 2015	1.0	null
esophageal	GeneRIF Biological Term Annotations	1.0	null
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.624254
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.51463
BRD-K67813189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63851
Penis carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
sex chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.336241
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	112.704
HOP-62	GDSC Cell Line Gene Expression Profiles	-1.0	-2.52849
BRD-K25866212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11475
caudal division of IPC (area 39)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.62409
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7252-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
paravermis of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.1006
salivary gland adenoid cystic carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.232836
PRR7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88194
KMM1	CCLE Cell Line Gene Expression Profiles	1.0	1.50403
JURKAT	DepMap CRISPR Gene Dependency	1.0	3.55668
SNU-475 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.568
MZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.4254
Dedifferentiated liposarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
ELF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85758
BRD-K18031793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1262
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.77023
PHOX2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24729
GSE164505,GSE164506_3_v_2_indisulam_human	RummaGEO Drug Perturbation Signatures	1.0	null
A4-Fuk	GDSC Cell Line Gene Expression Profiles	1.0	2.10003
SMAD3_01_352	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.71833
NCIH1355	CCLE Cell Line Gene CNV Profiles	-1.0	-1.90412
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
BRD-K01894374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40157
LNZ308	CCLE Cell Line Gene CNV Profiles	1.0	1.44132
FUT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90987
CRCGN015_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8798
Autonomic nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
GSE223893_11_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K83794624_P8624_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.896382
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.80215
BRD-K76645599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25827
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
z disc	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.728836
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.897
posterior (caudal) superior temporal cortex (area 22c)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.44649
peripheral portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08095
melanocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076555
BRD-K24992635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00952
Annulate lamellae	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.536
BRD-K47951859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46212
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.995489
BRD-K68617666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15715
BRD-K28785305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84812
RPMI7951	CCLE Cell Line Gene Expression Profiles	-1.0	-2.15177
BRD-K70237115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14425
GSE174701_5_v_8_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
orphenadrine-4537	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100663_TCx_no dementia_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.64219
PMC7782698-41467_2020_20367_MOESM9_ESM.xlsx-Student_s_t-test_BP1_ILK_GFP-Gene_names_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
penis carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.829049
Rectal Mucosa Donor 31	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.27505
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A4BB-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
directed	GeneRIF Biological Term Annotations	1.0	null
JVM3	DepMap CRISPR Gene Dependency	1.0	2.34509
magea36	GeneRIF Biological Term Annotations	1.0	null
BRD-A25184723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.35525
RNASEH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95822
IZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16134
5902_NUP88_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.531381
clomipramine-3182	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pridinol-7214	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039612
ZDHHC23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32207
BRD-A98714080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02754
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.11302
liposarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.232836
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A69H-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K60080002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02746
Round Cell Liposarcoma	DisGeNET Gene-Disease Associations	1.0	null
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.551
7127_RASSF3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.527942
Cytotoxic T-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.817
ampulla	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.373493
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.42867
BRD-K65228230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23438
vascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05343
ZIC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.2849
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8001-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PTK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95954
identification	GeneRIF Biological Term Annotations	1.0	null
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08935
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HE-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
antigen	GeneRIF Biological Term Annotations	1.0	null
BRD-K92124212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01142
primary auditory cortex (core)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04279
2376_DROSHA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.641823
Skeletal muscle cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
FLNC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71467
BRD-K68008192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40492
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00745
gastric cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN010_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55497
GSE169356_0_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HPAF-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.511
IL1RAPL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00795989
BRD-K20377072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05945
BRD-K98408839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05135
Ovary	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.859384
EKVX	BioGPS Cell Line Gene Expression Profiles	1.0	1.271
magea1	GeneRIF Biological Term Annotations	1.0	null
SW756	DepMap CRISPR Gene Dependency	1.0	2.25516
laterodorsal part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17778
LIVF001-027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04463
Uroepithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.322
BRD-K81418486_vorinostat_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Rhabdomyosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.115
JHH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06424
BRD-K83547183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.34303
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.833
OUMS27	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38605
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.00303
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054502
BRD-K75814223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05453
GSE169205_3_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.29516
GSE223893_1_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27217
GSE152699,GSE152723_3_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EXOSC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90244
most	GeneRIF Biological Term Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7579-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
products	GeneRIF Biological Term Annotations	1.0	null
esophageal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.350372
primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.905859
estradiol-6928	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAK	Kinase Library Serine Threonine Kinome Atlas	1.0	null
KMS-12-BM	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.92126
posterior (caudal) superior temporal cortex (area 22c)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.895742
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.714
capillary hemangioma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.528063
Lung adenocarcinoma_LUAD_TCGA-44-7667-01A-31R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreatic carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
Clathrin coat of coated pit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.703
Liver hepatocellular carcinoma_LIHC_TCGA-T1-A6J8-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DPF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03948
CENPVL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73532
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.281
BRD-K62983405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46061
BRD-K45328741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33908
allele	GeneRIF Biological Term Annotations	1.0	null
SBC-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.892538
505_ARL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.736613
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81M-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
T cell receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.578
BRD-K22534934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05033
GSE74251_2_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.547
BRD-K07762753_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.023
Myeloma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.365
ihcrtpcr	GeneRIF Biological Term Annotations	1.0	null
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.2698
SYK_knockdown_280_GDS3609	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.19988
VPS29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47563
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41P-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K27843502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78945
Serous cystadenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
BRD-K67666705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17467
4944_MED21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.747343
U266B1	CCLE Cell Line Gene CNV Profiles	1.0	1.68794
HCC1428	CCLE Cell Line Gene Expression Profiles	1.0	1.77495
Head and neck squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
TBCEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85879
Brain Lower Grade Glioma_LGG_TCGA-P5-A5F0-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K14306031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37868
2541_EIF2S1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.675022
6276_PHB_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.532894
GCT	GDSC Cell Line Gene Expression Profiles	1.0	1.70626
BRD-K98271666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22594
myeloma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.449571
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A13I-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pericentriolar material	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.688
there	GeneRIF Biological Term Annotations	1.0	null
SPATA33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65692
BRD-K57365604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02309
LETETRESGENE AUTOLEUCEL	DGIdb Drug Targets 2026	1.0	52.932
cellular_component	GO Cellular Component Annotations 2015	1.0	null
Transitional cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.55
lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.452208
OlfactoryBulb	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.07932
CUL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51862
ACOT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07038
CRCGN016_MCF10A.TP53.M_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.35511
Liposarcoma	DisGeNET Gene-Disease Associations	1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.712
BRD-K75440064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09212
BRD-K59159023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03991
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.201335
BRD-K43909206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75519
BRD-K41025232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06131
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.87388
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
DMS454	CCLE Cell Line Gene CNV Profiles	1.0	2.58283
BRD-K47854067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51262
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.92855
Microtubule organizing center	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K45893504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.128
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29649
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
6847_PSMA7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.507803
DRGX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42145
timolol-5645	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE135030_8_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.0084
vacuole	LOCATE Predicted Protein Localization Annotations	1.0	null
cover	GeneRIF Biological Term Annotations	1.0	null
BRD-K51654114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33006
GSE212330_1_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
amygdaloid complex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.6288
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.048395
VMRC-LCD	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	558.455
BRD-K94751306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34938
EZH2	ENCODE Transcription Factor Targets	1.0	null
Connective tissue cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.747
mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058797
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.763
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.604
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.569
GSE123105,GSE124556_0_v_2_pcf11_human	RummaGEO Gene Perturbation Signatures	1.0	null
hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.364824
non-hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.133864
BRD-K44086628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42058
tRNA metabolic process	GO Biological Process Annotations 2025	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K65780164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34569
GSE221327_8_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OE19	CCLE Cell Line Gene Expression Profiles	1.0	1.47741
BDCA4+_DentriticCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.39972
H3K9me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K06243138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34607
Marrow	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.303
BRD-K86288396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15799
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A719-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7429-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.231
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.989769
SNU216	CCLE Cell Line Gene CNV Profiles	1.0	1.45803
T47D	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6465
BRD-K76755163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0841
PARP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23991
water vascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.373493
Squamous Cell Carcinoma Of Esophagus	DisGeNET Gene-Disease Associations	1.0	null
LRRK2_mutant_32_GDS4400	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.00411
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SB-01A-21R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
9962_ZBED2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.765693
EBF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0017
ACSS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2007
BRD-K25312635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29902
H3K9me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
myeloma	GeneRIF Biological Term Annotations	1.0	null
DHX35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67497
OC-314	GDSC Cell Line Gene Expression Profiles	-1.0	-1.67711
CRCGN016_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.26098
MYO1E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76691
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.930997
BRD-K46588240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.47035
16042785-tableS3	GeneSigDB Published Gene Signatures	1.0	null
Carcinoma, Ovarian Epithelial	DisGeNET Gene-Disease Associations	1.0	null
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
16168083-Table2	GeneSigDB Published Gene Signatures	1.0	null
Perturb_8061_KO_ZCCHC4_SRP350212	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.82264
NAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1451
esophageal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.159124
CRCGN016_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.79143
SCLC21H	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48955
isolated	GeneRIF Biological Term Annotations	1.0	null
BRD-K24178822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35535
PMC8567280-EMBR-22-e53014-s008.xlsx-PC3_TIP5_bound_promoter-Unnamed_4_BAZ2A	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH522	CCLE Cell Line Gene Expression Profiles	1.0	1.74265
MZ in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03613
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K03901181	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4531
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.1
NCIH1755	CCLE Cell Line Gene Expression Profiles	1.0	1.42351
CRCGN015_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.62601
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A726-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU761	DepMap CRISPR Gene Dependency	1.0	2.90281
testis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.80006
Lung squamous cell carcinoma_LUSC_TCGA-66-2778-01A-02R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPM1N	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7115
UBE2M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27914
Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hep-G2/2.15 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.78
EBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.9863
WASF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39964
BRD-K90965240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70626
Leukemialymphoblastic(MOLT-4)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.24167
stomach	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064619
MDAMB453	CCLE Cell Line Gene CNV Profiles	1.0	1.77197
VMRCLCD	CCLE Cell Line Gene Expression Profiles	1.0	2.12223
8184_SMN2_ENST00000380743.4	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.509461
mitral valve stenosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.461639
OVCAR433	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.50862
BRD-K12879624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45096
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7413-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Clathrin coat of trans-Golgi network vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.793
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7388-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K66641352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09278
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PK-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37615
THAP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6352
ethambutol-4120	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K99252563_QL-XII-47_HME1_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cellular myxoid liposarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.771
BRD-K64111129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42809
BRD-K70648728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19573
GSE191015_1_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
9364_TSR1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.523374
CRCGN017_MCF10A.WT.HP_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13057
clorgiline-6659	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lymphoid tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.758259
BRD-K14055576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14548
GSE206516,GSE206518_6_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
etamsylate-4576	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE213588_10_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
adenocarcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SJ-01B-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF544	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98491
liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.243995
uterus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
FBXO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20345
Human papillomavirus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.232
meninx	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.14361
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03096
EBV-B cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.031
SW837	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
fallopian tube	GTEx Tissue Gene Expression Profiles	-1.0	-1.0856
GSE147876,GSE147877_4_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
8433_SRSF3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.84508
2899_TASOR_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.597616
CRCGN015_HEPG2_48H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25866
22RV1	CCLE Cell Line Gene Expression Profiles	1.0	1.55547
BRD-K71647210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03473
THRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.4615
ZFAND2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88926
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.9262
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.703764
vascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067932
624 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.39
Renal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.241
male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.370737
GSE218060_7_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100500_PCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	6.19826
BRD-K95343362	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15323
BRD-K70577657_H-9 dihydrochloride_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SUDHL10	DepMap CRISPR Gene Dependency	1.0	10.0713
LN18	BioGPS Cell Line Gene Expression Profiles	1.0	1.01874
good	GeneRIF Biological Term Annotations	1.0	null
three	GeneRIF Biological Term Annotations	1.0	null
alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K36111748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34076
evaluated	GeneRIF Biological Term Annotations	1.0	null
BRD-K43306617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53238
GSE221327_10_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
butirosin-2518	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-RS-A6TO-01A-32R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_3H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21096
demonstrate	GeneRIF Biological Term Annotations	1.0	null
BRD-K49031847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67284
benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04735
clearly	GeneRIF Biological Term Annotations	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.871483
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.3799
RRP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32243
BRD-K87180723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16694
BRD-K23424219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13829
sp1_22099172_dental_follicle_cell_gof_human_gpl11532_gse31628	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.651502
SW1271	COSMIC Cell Line Gene Mutation Profiles	1.0	null
COL9A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57669
ACHN	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.24777
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.998485
NME7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00388706
BRD-K81142122_STK249718_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-7670-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-A4DF-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Myeloid neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.968
GSE178714_6_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K43456220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2245
BRD-A75421526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1238
esophageal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.346777
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.30232
BRD-K82768815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1322
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BICR18	CCLE Cell Line Gene CNV Profiles	1.0	1.60144
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055613
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HF-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K86250672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33856
Perturb_10392_KD_TP63_SRP273737	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Barrett's esophagus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.005
CRCGN015_MCF10A_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19931
showed	GeneRIF Biological Term Annotations	1.0	null
BRD-K54576503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12706
meningioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.774004
internal male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.54343
BRD-K65506286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00089
ZNF519	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75528
contractile fiber part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.471609
reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.517649
SAOS2	BioGPS Cell Line Gene Expression Profiles	1.0	1.15335
GSE221327_4_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K73995655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05556
GSE221327_4_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-A49D-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100360_FWM_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.05457
BRD-K26680822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59666
Prostate epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.735
inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01922
BRD-K92468187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06383
496100579_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	5.17807
coding	GeneRIF Biological Term Annotations	1.0	null
processed	GeneRIF Biological Term Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HH-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LB373-MEL-D	GDSC Cell Line Gene Expression Profiles	1.0	1.62574
Mature B-cell neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.01069
PMC3921136-CIN-13-2014-021-s001.pdf-51-CSRNP2_CSRNP2	Rummagene Transcription Factor Associations 2026	1.0	null
GATC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57094
CRCGN015_MCF10A_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5294
gastric corpus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.362273
GSE213588_8_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary motor-sensory cortex (samples)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.831227
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV6-01A-21R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.171
anterodorsal nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.987085
CHSA0011	COSMIC Cell Line Gene Mutation Profiles	1.0	null
esophageal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.648533
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZA-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100359_PCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.4881
KLF15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8213
lysosome	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE48812_4_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K25718630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37126
Stomach Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
Acute lymphoblastic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.34
specific	GeneRIF Biological Term Annotations	1.0	null
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.656287
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.945802
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.213
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7071-01A-12R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.1039
BRD-A14424697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32114
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BX-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN013_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.03131
BRD-K21036759	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55818
GSE221327_6_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100318_PCx_probable Alzheimer's disease_TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.22157
BRD-K28349636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57034
Carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NCIH1793	CCLE Cell Line Gene Expression Profiles	1.0	1.65897
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.865043
KLF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	92.3878
BRD-K02630367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26137
CLASP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58445
4153_INTS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.510838
BRD-K78886448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74456
BRD-A79465854_auranofin_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
peripheral	GeneRIF Biological Term Annotations	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.24915
EMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53761
exerted	GeneRIF Biological Term Annotations	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.47608
Brain Lower Grade Glioma_LGG_TCGA-DB-A64O-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K95885906_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
P53_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-62-8402-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A29082194_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8620-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A410-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fetus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.316224
BRD-K48875630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52663
CRCGN016_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.12902
GPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80735
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Lung squamous cell carcinoma_LUSC_TCGA-66-2754-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K95171874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20262
reducing	GeneRIF Biological Term Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-21-5783-01A-41R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K14087001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66919
Bone marrow disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.944
EIF2AK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80688
indirectly	GeneRIF Biological Term Annotations	1.0	null
GSE48812_11_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
inner CP in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0518
presented	GeneRIF Biological Term Annotations	1.0	null
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.562
Stomach carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.031
germ cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.704355
BRD-K48592348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66417
CAPAN-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.539
CRCGN017_MCF10A.TP53.M_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5099
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7885-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AEBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82601
anterior (rostral) cingulate (medial prefrontal) cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06779
BRD-K12826618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64503
ASCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21263
ZNF707	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.4529
8432_SRSF2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.507328
GSE95077_1_v_0_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
hiatus hernia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.442418
BRD-K21680192_mitoxantrone_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RMUGS	DepMap CRISPR Gene Dependency	1.0	6.72298
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.366
C32	DepMap CRISPR Gene Dependency	1.0	2.67129
Photoreceptor proximal connecting cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.03
etifenin-2477	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7379-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hes1	GeneRIF Biological Term Annotations	1.0	null
Plasma cell leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.015
BRD-K81418486_vorinostat_RMGI_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
10751_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.626902
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06813
organ system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.050604
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.55362
biological_process	GO Biological Process Annotations 2015	1.0	null
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044343
RNA metabolic process	GO Biological Process Annotations 2023	1.0	null
GSE240386,GSE242143_1_v_4_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
7161_RBM17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.519537
delsoline-7212	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
posteroventral (inferior) parietal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.917161
BRD-K49042040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59874
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.052561
WICH complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.551
LRFN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56189
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.219047
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.255
H1-3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82403
BRD-A52193669_2816_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.87275
BRD-K00300115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86839
Kidney cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.357
CRCGN015_HEPG2_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7701
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
i band	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.690764
BRD-K21680192_mitoxantrone_HS578T_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A4MW-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.914876
CRCGN015_MCF10A.WT.HP_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05604
Synovial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.255
Plasma cell neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.253
GSE96777,GSE96778_1_v_0_zbtb4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SNUC5	CCLE Cell Line Gene CNV Profiles	1.0	1.38095
ATF2_01_206	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.90853
Chronic lymphocytic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.062
primary motor cortex (area M1, area 4)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17201
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.241356
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.45488
H4C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54457
liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.336144
BRD-K05050615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06879
BRD-K52001024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47769
BRD-K11893906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10293
nyeso1lage1s	GeneRIF Biological Term Annotations	1.0	null
clinical	GeneRIF Biological Term Annotations	1.0	null
BL1096 (DYRK2)	NURSA Protein Complexes	1.0	null
HNRNPDL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11452
Uterine disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.096
Head and neck cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.194
BRD-K10705233_GW405833 hydrochloride_RMGI_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	109.135
MPDU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16912
BRD-K54420800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90956
BRD-K83794624_P8624_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.176215
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.703626
ssx1	GeneRIF Biological Term Annotations	1.0	null
TP53_01_286	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.8704
BRD-K88351048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0103
BRD-K84090286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44801
frequently	GeneRIF Biological Term Annotations	1.0	null
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.8647
plasma membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042752
because	GeneRIF Biological Term Annotations	1.0	null
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.50862
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054128
PVR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6928
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.9018
primary motor cortex (area M1, area 4)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.60529
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-8298-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
trans-Golgi network transport vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.774
P30-OHK	GDSC Cell Line Gene Expression Profiles	-1.0	-1.61447
H3K27ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K94088431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56339
cases	GeneRIF Biological Term Annotations	1.0	null
HEC50B	CCLE Cell Line Gene CNV Profiles	1.0	1.6017
primary motor cortex (area M1, area 4)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.944488
MDAMB468	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.834102
dendritic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.216933
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	90.4561
Somatotrophinoma, Familial	DisGeNET Gene-Disease Associations	1.0	null
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08935
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
PITX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2669
CYP20A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.96382
SPG21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05892
JM1	DepMap CRISPR Gene Dependency	1.0	7.37408
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052974
BRD-K19168437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52498
BRD-K55311609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12094
ZNF417	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6016
TGW	GDSC Cell Line Gene Expression Profiles	1.0	1.58826
FUBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10576
female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.220424
GSE148657_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
microtubule organizing center	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.902842
among	GeneRIF Biological Term Annotations	1.0	null
SCX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21811
Monoclonal gammopathy of uncertain significance	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.347
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052043
BRD-K83393282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18343
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.568389
TGM2_KD_GSE23702_715_human_NB4 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
multiple	GeneRIF Biological Term Annotations	1.0	null
BRD-K13225050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12862
Squamous Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Glycated hemoglobin levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	10.0
Kidney renal clear cell carcinoma_KIRC_TCGA-AS-3777-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AP-2 adaptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.705
BRD-K80622725_STK397047_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6392-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K65829768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85983
HCC33	CCLE Cell Line Gene Expression Profiles	-1.0	-1.88741
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TC-01A-21R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
doxycycline-2737	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PC-3	GDSC Cell Line Gene Expression Profiles	-1.0	-1.61724
intracellular non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.078598
clathrin-coated endocytic vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.698
GSE178714_6_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.9562
Lung adenocarcinoma_LUAD_TCGA-86-7955-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.84305
stimulate	GeneRIF Biological Term Annotations	1.0	null
NDUFAF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52454
SKMEL2	BioGPS Cell Line Gene Expression Profiles	1.0	0.903786
BRD-K11927976_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UBAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29869
GSE221327_5_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.89147
BRD-K30548577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08933
Lung squamous cell carcinoma_LUSC_TCGA-NK-A5D1-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.755
Testis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.582
Esophageal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.993
GSE216757_0_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K54023716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0934
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GI-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
esophageal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.36825
BRD-K43326597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2291
gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.049416
PK-59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00745
ventrolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.54722
tRNA threonylcarbamoyladenosine metabolic process	GO Biological Process Annotations 2025	1.0	null
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
aberrant	GeneRIF Biological Term Annotations	1.0	null
Prostate adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.616
pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.187719
skin	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.33461
Stomach Smooth Muscle	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.28627
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K96764878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20905
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PANC 05.04	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.853893
GSE89154_1_v_2_proscillaridin_human	RummaGEO Drug Perturbation Signatures	1.0	null
nimodipine-3103	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	164.048
DK-MG	GDSC Cell Line Gene Expression Profiles	-1.0	-1.43691
TOR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97292
BRD-K77965546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12261
solitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00062
OCILY19	DepMap CRISPR Gene Dependency	1.0	3.10547
E2F1	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K85493820_KM 00927_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27859
gastroesophageal junction	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.851266
Lung squamous cell carcinoma_LUSC_TCGA-85-A4JB-01A-51R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
4147_INTS2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.538906
caudal prosubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.38733
VZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.874821
PRMT7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00389106
GSE135030_8_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
binding	GO Molecular Function Annotations 2015	1.0	null
mature b-cell neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.136033
CRCGN015_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.33128
BRD-K95858622_NCGC00182609-01_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
first	GeneRIF Biological Term Annotations	1.0	null
GSE213588_10_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A20F-06A-21R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K40960913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3433
Adenocarcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
METTL7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95019
DDIT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85491
2658_EP400_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.619088
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.23138
GSE214248_0_v_1_cxcl8_human	RummaGEO Gene Perturbation Signatures	1.0	null
MPHOSPH9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23419
inner SZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10313
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YY-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE240386,GSE242143_1_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
QGY-7703 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.594
medial subdivision of area 10	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23896
heart	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059039
GSE165334_2_v_0_dabrafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SPATC1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44618
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.303198
5165_MPHOSPH8_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.552722
dorsolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.57075
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_3_AP1_Up_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
DDX31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36069
clones	GeneRIF Biological Term Annotations	1.0	null
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27289
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.44874
BRD-K20895937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.69413
A4FUK	CCLE Cell Line Gene Expression Profiles	1.0	1.44599
BRD-K98548675_Parthenolide_SW620_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
refractive error	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.058424
lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.406051
BRD-K94469522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11642
ZNF343	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.289
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	81.7253
HS944T	CCLE Cell Line Gene Expression Profiles	1.0	2.41154
CTAG/Pcc1 family	InterPro Predicted Protein Domain Annotations	1.0	null
promiscuous	GeneRIF Biological Term Annotations	1.0	null
BRD-A24396574_celastrol_HME1_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC1806	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.739229
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6385
TIGD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15069
EBC1	DepMap CRISPR Gene Dependency	1.0	2.52202
Liposarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.722
A172	DepMap CRISPR Gene Dependency	1.0	2.11026
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7915-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.620731
15897907-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.36449
ZNF684	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.8043
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KRAS.600_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.05986
Lung adenocarcinoma_LUAD_TCGA-NJ-A55R-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.213283
GSE221327_6_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00497
G292CLONEA141B1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.48372
suppressor	GeneRIF Biological Term Annotations	1.0	null
2925_FAM50A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.539639
A3-KAW	GDSC Cell Line Gene Expression Profiles	1.0	2.75117
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.528
CRCGN014_HEPG2_3H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76801
ACOT13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70082
laterodorsal subdivision of area 8	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.67043
centrosome	LOCATE Curated Protein Localization Annotations	1.0	null
ICK	Kinase Library Serine Threonine Kinome Atlas	1.0	null
LCLC-97TM1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.847251
cochlear nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.54198
SP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37617
G122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.996292
Skin Cutaneous Melanoma_SKCM_TCGA-QB-A6FS-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
frequency	GeneRIF Biological Term Annotations	1.0	null
NLGN4Y	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78852
gamma-delta T cell receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.752
posteroventral (inferior) parietal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.880075
SP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.89555
octreotide	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.77691
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HIC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.13165
7152_RBM10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.655848
cell part	GO Cellular Component Annotations 2015	1.0	null
2545_EIF3B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.513978
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.031
7657_SARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.5716
BRD-A68009927_daunorubicin_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FW-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Vgamma9Vdelta2 T-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.735
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K48195722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49021
paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08466
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055911
Pituitary carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.27
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03636
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A57E-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCM8-MCM9 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.187
GSE221327_8_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.11243
BRD-K18290923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50799
BRD-K14181473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50727
GSE221327_4_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.6035
MXD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45704
RBBP5	ENCODE Transcription Factor Targets	1.0	null
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.96128
hladr11	GeneRIF Biological Term Annotations	1.0	null
6549_POLR2H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.639809
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20826
BRD-K91654198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47629
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE188570,GSE188571_5_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
OVCA 429	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.957007
TCF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.6103
KDM4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8164
MN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97218
proportion	GeneRIF Biological Term Annotations	1.0	null
epidermal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069515
GAIT complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.642
primary visual cortex (striate cortex, area V1/17)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.88319
6625_PPIE_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.582429
BRD-K45200389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71534
16643655-1300GenesList	GeneSigDB Published Gene Signatures	1.0	null
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040404
orbital frontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.905887
epithelial cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RERFLCAD2	CCLE Cell Line Gene CNV Profiles	1.0	2.11021
GSE208350_0_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Sarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.777
Lung adenocarcinoma_LUAD_TCGA-64-5775-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100344_HIP_probable Alzheimer's disease_TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.73611
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.687
PABPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79498
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.554
GSE169356_0_v_5_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
parameters	GeneRIF Biological Term Annotations	1.0	null
cancer	GAD High Level Gene-Disease Associations	1.0	0.293278
interesting	GeneRIF Biological Term Annotations	1.0	null
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.79
CRCGN008_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05624
capability	GeneRIF Biological Term Annotations	1.0	null
raphe obscurus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09942
low	GeneRIF Biological Term Annotations	1.0	null
ALVA31	BioGPS Cell Line Gene Expression Profiles	1.0	0.868522
TAF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70613
OPM2	CCLE Cell Line Gene Expression Profiles	1.0	1.3906
STAT3	JASPAR Predicted Transcription Factor Targets	1.0	null
4942_MED1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.56652
BRD-K95648552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35186
detected	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MP-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ovarian carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1902
amygdaloid complex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10843
Lung adenocarcinoma_LUAD_TCGA-55-6983-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10122_KD_ATF3_SRP009615	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.6451
OPM-2	GDSC Cell Line Gene Expression Profiles	1.0	1.92649
Lung squamous cell carcinoma_LUSC_TCGA-33-4586-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A86748098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1783
7513_RPS24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.538187
RCCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12788
ATP8B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61696
microtubule organizing center	GO Cellular Component Annotations 2015	1.0	null
nyeso1	GeneRIF Biological Term Annotations	1.0	null
advanced	GeneRIF Biological Term Annotations	1.0	null
BRD-A58937872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.67315
organelle part	LOCATE Curated Protein Localization Annotations	1.0	null
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.34789
SW 780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.854583
Lung adenocarcinoma_LUAD_TCGA-35-5375-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
apigenin-4578	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K73261251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27474
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.038
MDA MB435	BioGPS Cell Line Gene Expression Profiles	1.0	2.41625
496100481_PCx_no dementia_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.79722
Clathrin coat of endocytic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.704
cyproterone-3545	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.17173
contractile fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.421604
primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.04719
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.18356
ZNF664	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47219
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-P53_DN_V1_UP-Ensemble_gene_ID_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3B5-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inner CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04335
HS294T	CCLE Cell Line Gene Expression Profiles	1.0	2.8018
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.178877
CRCGN008_HEPG2_24H:I17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31738
2747_ESYT1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.69469
BRD-K63145939	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0319
CRCGN013_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.41955
MDAMB175VII	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.90772
9424_TUBG1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.637512
HSF1_KD_GDS1733_755_human_HeLa cells - 0.5 Hour by siHSF1_2	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
AXIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.39929
BRD-K24614157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06446
mhc protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.126431
H3K27me3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AP-1 adaptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.794
BRD-K25187028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77702
Blood protein disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
Prostate adenocarcinoma_PRAD_TCGA-FC-A66V-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K45315294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21248
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11822
15489886-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
Sarcoma_SARC_TCGA-QQ-A5V9-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K17120673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24314
7607_RUVBL1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.668666
sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040296
BRD-K53356402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01894
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
Peripheral nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.011
rate	GeneRIF Biological Term Annotations	1.0	null
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.722
ASCL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	80.8987
Multiple Myeloma	DisGeNET Gene-Disease Associations	1.0	null
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.2961
Cervix disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
COV434	DepMap CRISPR Gene Dependency	1.0	2.45247
GSE135030_8_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
blood vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054162
1408_CDC5L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.66684
cancers	GeneRIF Biological Term Annotations	1.0	null
6845_PSMA5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.679948
PMC9314667-Table_1.xlsx-Regulons-MITF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
RBM28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13269
6861_PSMC4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.598634
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
bone cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059797
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.4315
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.48301
TE125T	CCLE Cell Line Gene Expression Profiles	-1.0	-2.0169
BRD-K80921954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0931
GALT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62708
digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-A38359809	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20409
SUDHL10	CCLE Cell Line Gene CNV Profiles	1.0	1.72834
Lung squamous cell carcinoma_LUSC_TCGA-18-4083-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062025
BRD-A89575866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01381
targets	GeneRIF Biological Term Annotations	1.0	null
UBE3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96452
PMC11749115-loae020_suppl_Supplementary_Table_S2.xlsx-CHOP-high-gene_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
HGC-27	GDSC Cell Line Gene Expression Profiles	1.0	1.44012
they	GeneRIF Biological Term Annotations	1.0	null
BRD-K97410356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15912
GSE147876,GSE147877_4_v_9_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
KMS12BM	CCLE Cell Line Gene Expression Profiles	1.0	1.35292
decitabine_homo sapiens_gpl570_gse30985	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8507-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Toxic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.9103
BRD-K07959057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08295
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.691
oral cavity cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.083616
B-cell acute lymphoblastic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.303
FU97	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59011
BRD-K54931539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32885
6870_PSMD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.774705
PMC4634137-ncomms9549-s7.xlsx-ZF_Hair_cell_data-Unnamed_1_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN010_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92075
blood	GeneRIF Biological Term Annotations	1.0	null
GSE223893_2_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
clathrin-coated vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.002
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.834958
Neuroblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
BRD-K62800316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26621
outer CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.41286
hsa-miR-4476	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.479
BRD-A19037878_trichostatin A_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
prasterone-3097	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RJ-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chondrosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.448346
ZUP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56553
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05344
EKC/KEOPS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.464
CRCGN015_MCF10A.WT.HP_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.00372
BRD-K39020351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48282
MDS - Myelodysplastic syndrome_Bone marrow stem cell_GSE4619	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.3808
4955_MED4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.585506
peripheral t-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.344941
Hepatoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5152-01A-02R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAZ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	147.643
BRD-K62833556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04111
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7II-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE240386,GSE242143_8_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K98548675_Parthenolide_NOMO1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
6797_PRPF3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.661483
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.59188
their	GeneRIF Biological Term Annotations	1.0	null
SKNSH	DepMap CRISPR Gene Dependency	1.0	3.49552
IKZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.23779
type	GeneRIF Biological Term Annotations	1.0	null
BRD-K76426411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49131
CRCGN017_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62957
NCIH2030	CCLE Cell Line Gene CNV Profiles	1.0	1.46529
non-membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
CCRF-CEM	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K12613826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05547
SHOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02157
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29391
Lung adenocarcinoma_LUAD_TCGA-44-8119-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.919
KMRC1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.01813
KDM5B	ENCODE Transcription Factor Targets	1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.697
BRD-K20799008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53803
PTGIS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84222
Mccoy	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.661
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.03139
BRD-K12929741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01969
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.895477
stomach	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
AU565	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.29837
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.216111
Lung squamous cell carcinoma_LUSC_TCGA-21-5787-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.4104
BRD-A35588707_TENIPOSIDE_PC3_24.0_h_1.25_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45X-01A-21R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.279
Synovial sarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.144
multiform (lateral) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.837092
GSE202434,GSE202438_6_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
cellular myxoid liposarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.70434
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.851
4317_KDM1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.516337
6844_PSMA4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.533824
vascular endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063656
Thymus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.72848
cardiovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052901
2537_EIF2B3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.525432
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.278
3980_HSPA9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.516091
HUH28	CCLE Cell Line Gene Expression Profiles	1.0	1.5932
106_ACTL6A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.618339
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
Perturb_8357_KO_DAPK1_SRP356770	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.4267
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
uterine cervix	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Peripheral blood stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.892
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PZ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6857_PSMC1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.501314
sulfabenzamide-6634	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K68202226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38285
BRD-K38854468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04681
NCI-H1781	COSMIC Cell Line Gene Mutation Profiles	1.0	null
candidates	GeneRIF Biological Term Annotations	1.0	null
NIHOVCAR3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34772
Esophagus - Gastroesophageal Junction	GTEx Tissue Gene Expression Profiles 2023	1.0	7.21226
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.369
ZNF740	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	286.885
BRD-K71836501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60806
Perturb_6638_KO_IKZF1_SRP139731	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K30795375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10092
MAFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19648
BRD-A05828965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60438
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4436
Lymphoid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.348
cytotoxic t-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.731854
BRD-K99252563_QL-XII-47_SKBR3_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-RP-A695-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Renal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.248
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.705291
BRD-K29684372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13938
rda	GeneRIF Biological Term Annotations	1.0	null
GCIY	GDSC Cell Line Gene Expression Profiles	1.0	1.54391
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Clathrin vesicle coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.01
2624_EML2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.682464
CSRNP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99177
a95	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.794
PMC12769604-13402_2025_1147_MOESM6_ESM.xlsx-Table_S4_3_Venn-Scissor_AND_Tumor_NOT_Prognosis_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K41009039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43921
CRCGN015_HEPG2_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.07739
TestisGermCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.87522
donors	GeneRIF Biological Term Annotations	1.0	null
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.481
cultures	GeneRIF Biological Term Annotations	1.0	null
Malignant ovarian surface epithelial-stromal neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.155
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BS-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7504_RPS15_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.542752
regions	GeneRIF Biological Term Annotations	1.0	null
BRD-K15800236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.75588
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	169.565
PRC1_BMI_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
amorolfine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14018
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.583
embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE95077_1_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_3_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ARHGAP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79696
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
plasma membrane	LOCATE Curated Protein Localization Annotations	1.0	null
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3801
PMC3923219-mmc2.xls-Table_S1-Table_S1_Differential_Gene_Expression_in_GFP-PRDM1_transduced_H9_hESCs_PRDM1	Rummagene Transcription Factor Associations 2026	1.0	null
CAG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.866
dexamethasone_homo sapiens_gpl6244_gse20963	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cycloserine-6139	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MOPC-315 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.886
GSE223893_11_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.785
7338_RNF113A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.5019
HCC1937	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53
Lung adenocarcinoma_LUAD_TCGA-64-5774-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.316
Brain Lower Grade Glioma_LGG_TCGA-DU-A6S3-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GRPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51217
GLA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00555448
8040_SLC35A4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.749661
Warsaw breakage syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.399871
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PD-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19B-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A5UE-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
epithelioma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
20174566-TableS1	GeneSigDB Published Gene Signatures	1.0	null
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.5904
Centrosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
TBX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53115
CRCGN011_HEPG2_24H:H12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19416
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11822
melanoma cell line	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
8621_SYMPK_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.501494
CRCGN017_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.82952
CENPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73286
17760805-SuppTableS3b	GeneSigDB Published Gene Signatures	1.0	null
Osteosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	118.188
BRD-K95035301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3905
Uterus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.78778
BRD-K22384464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08318
Perturb_8452_KD_NME7_SRP332606	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.47132
3503_GPN2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.520731
Male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.308
NCI-H520	GDSC Cell Line Gene Expression Profiles	-1.0	-1.53631
GSE239688_2_v_5_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SH4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46564
Cervical cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
BRD-K29144638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66106
Lung squamous cell carcinoma_LUSC_TCGA-94-A5I6-01A-21R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZSCAN31	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.3487
than	GeneRIF Biological Term Annotations	1.0	null
lymphoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.716651
RPMI7951	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58689
MAPACHS77	DepMap CRISPR Gene Dependency	1.0	2.05807
BRD-K21866464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02892
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44164
dlx4_00000000_mcfdash7_gof_human_gpl201_gse21657	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.840635
BRD-K59598504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19367
GSE226770_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
D502MG	DepMap CRISPR Gene Dependency	1.0	4.96468
ventrolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23617
immunogenicity	GeneRIF Biological Term Annotations	1.0	null
Esophageal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-6514-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K75293299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27319
BRD-K73110675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43366
Internal male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.348
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.04141
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053136
NCIH196	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34328
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.17979
BRD-K91180296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24285
outer SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.93851
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SETDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28233
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4696-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-P53_DN_V1_UP-Gene_name_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
NB10	DepMap CRISPR Gene Dependency	1.0	4.50621
H513	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K44483161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62296
BRD-K22957824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6088
LAMTOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55773
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00339
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EL-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7152_RBM10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.649191
4696_LSM6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.501139
BRD-K52124788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12885
ZFY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86873
NCIH2073	CCLE Cell Line Gene CNV Profiles	-1.0	-2.20459
Pancreatic adenocarcinoma_PAAD_TCGA-LB-A7SX-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.216111
TADA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69777
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.872749
PSORS1C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99858
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
outer CP in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.46467
EGI1	DepMap CRISPR Gene Dependency	1.0	2.2495
centrosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
hydrocortisone_homo sapiens_gpl201_gse21909	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JHUEM3	CCLE Cell Line Gene Expression Profiles	-1.0	-2.16111
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE153443_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
AMO1	CCLE Cell Line Gene Expression Profiles	1.0	1.95829
BRD-K64001802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61087
SLU7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10788
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13238
BT549	DepMap CRISPR Gene Dependency	1.0	3.08026
GSE169205_0_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
RPMI-7951 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.533
HSPB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76502
mitral valve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.458241
PCYT1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17615
Smooth muscle cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.192
MOSPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08974
peptide	GeneRIF Biological Term Annotations	1.0	null
2976_FASTKD1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.88767
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.714033
Plasmacytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
4941_MED19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.584718
Uterine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.128
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.83632
camel	GeneRIF Biological Term Annotations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3I3-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A3M9-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.34509
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7601_RUNX2_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.558077
head capsule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.10624
MCAS	DepMap CRISPR Gene Dependency	1.0	2.47944
4940_MED18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.639969
naltriben-mesylate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84058
Peripheral blood lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.052
naturally	GeneRIF Biological Term Annotations	1.0	null
GSE212330_1_v_0_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
FBXO45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51507
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.811
Lung adenocarcinoma_LUAD_TCGA-49-6742-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
blood vessel endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062305
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19571
17131328-TableII	GeneSigDB Published Gene Signatures	1.0	null
orbital frontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.25216
NCI-H2170	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K21718444_KW-2449_MCF7_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SKBR3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.98733
BRD-K19817946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1224
described	GeneRIF Biological Term Annotations	1.0	null
BRD-K10343715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20405
paclitaxel_homo sapiens_gpl570_gse11550	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KDM2B-26808549-CHIP-SEQ-REH-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
testicular cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.163523
ERA-27197147-CHIP-SEQ-ENDOMETRIOID-ADENOCARCINOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
HCC38	CCLE Cell Line Gene CNV Profiles	1.0	1.87229
FBXL14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21048
BRD-A60245366_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A6B1-01A-12R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gastric cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN014_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76102
MCIDAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48644
BRD-K06029218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32616
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.71941
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.71
MROH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87035
uroepithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.508635
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.471
8618_SYF2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.729248
BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K30910725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28476
bone marrow cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.43227
bone cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.082132
GSE135030_8_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE95077_5_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066817
Synovial sarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.762
liver	GTEx Tissue Gene Expression Profiles	1.0	0.825706
orbital frontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.896438
BRD-K85985071_E3380_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
recognized	GeneRIF Biological Term Annotations	1.0	null
GSE213588_8_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Urinary bladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.434
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C3-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.508041
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.934031
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.12855
ZNRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50761
diclazuril	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03733
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K20847739	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66074
inner CP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.856143
KPT-185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03164
BRD-K87324885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.72198
Melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.133
bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056005
GSE169356_2_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZT-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q4-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.17173
Leukocyte disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.893
IZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.47143
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4846-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
B-CPAP	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.02372
BRD-K55465787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0091
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.47615
Breast carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.138
DMS114	CCLE Cell Line Gene CNV Profiles	-1.0	-1.73947
3986_HSPE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.555962
organelle	GO Cellular Component Annotations 2015	1.0	null
GSE221327_5_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RELA	JASPAR Predicted Transcription Factor Targets	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.1944
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.502707
primary auditory cortex (core)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.874744
COLO 800	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.73595
BRD-A13084692_troglitazone_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
epitope	GeneRIF Biological Term Annotations	1.0	null
ZEB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4742
BRD-K57719270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53253
BRD-K46726368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56894
PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
spontaneous	GeneRIF Biological Term Annotations	1.0	null
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
BRD-K16843478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19407
CRCGN016_MCF10A.TP53.M_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.40384
BRD-K31407552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52478
Melanoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.522
BRD3OS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63027
Lung adenocarcinoma_LUAD_TCGA-55-1592-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.70716
sulfamethizole-2536	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HW-A5KK-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.98007
pancreas adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.246098
similar	GeneRIF Biological Term Annotations	1.0	null
CRCGN016_MCF10A.TP53.M_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76207
easily	GeneRIF Biological Term Annotations	1.0	null
5659_NGDN_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.900539
outer CP in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09332
BRD-K39321814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13237
6855_PSMB6_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.664425
CRCGN015_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.66286
BRD-K92374432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00212
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-8148-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K32718856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80978
GSE240439_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
6843_PSMA3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.524923
Lung squamous cell carcinoma_LUSC_TCGA-66-2769-01A-02R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	137.511
melanoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.571219
BRD-K99803997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61857
SNU410	DepMap CRISPR Gene Dependency	1.0	2.59453
GALR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85553
ENPP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26821
PARD6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02729
BRD-K84391462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11981
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.583
Head and neck carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
HCC1187	CCLE Cell Line Gene Expression Profiles	1.0	1.38177
MJ	DepMap CRISPR Gene Dependency	1.0	3.75416
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	88.3501
BRD-K63654001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4027
PMC6639357-41467_2019_11150_MOESM4_ESM.xlsx-SupTab1_Activated_genes_diffex-Supplementary_Data_1_Fold_change_and_p-value_of_all_activated_protein_coding_genes_upon_DNMT1-KO_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K73880067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61554
GSE178714_1_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1835
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNU-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13172
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GS-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
possibly	GeneRIF Biological Term Annotations	1.0	null
meningioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.177139
BRD-K02809100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64306
subcutaneous tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.217346
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
esophageal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.332661
BRD-K59587063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11769
alternatively	GeneRIF Biological Term Annotations	1.0	null
BT474	CCLE Cell Line Gene Expression Profiles	-1.0	-1.56037
progesterone-receptor negative breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.155
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE135030_3_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-8144-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Esophageal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.593
microtubule organizing center	LOCATE Curated Protein Localization Annotations	1.0	null
carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN016_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65268
talampicillin-7014	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
magec1ct7	GeneRIF Biological Term Annotations	1.0	null
primary auditory cortex (core)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0274
OVCA 420	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.840144
COLO-668	COSMIC Cell Line Gene Mutation Profiles	1.0	null
6845_PSMA5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.620531
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	114.503
BRD-K86935536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83309
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.8088
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.4135
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.10007
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.216
primary auditory cortex (core)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.880778
A172	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.36465
BRD-K27584103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73111
RAMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21296
GINS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22724
GNG11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45212
BRD-K62965247_Tipifarnib-P2_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC9307901-mmc2.xlsx-S5-GATA6-AS1_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
ihc	GeneRIF Biological Term Annotations	1.0	null
centrosome	GO Cellular Component Annotations 2015	1.0	null
BRD-K77343050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29112
THEM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72522
posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.02306
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.03139
visceral mass	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.30464
MRGPRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44295
squamous	GeneRIF Biological Term Annotations	1.0	null
MZ in retrosplenial cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0107
CRCGN016_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.7678
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.945802
BRD-K56653679_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.01998
BRD-K07484899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30292
BRD-K73032790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6066
BRD-K75074041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47082
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2268
GSE216757_4_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
lage1a	GeneRIF Biological Term Annotations	1.0	null
NCIH1373	CCLE Cell Line Gene CNV Profiles	1.0	1.34948
1570_CHERP_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.771026
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7541
HOXB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92444
chondrosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.168148
BRD-K07557785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63317
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.4563
GSE163240_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_4_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2543_EIF2S3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.604175
Retrotransposon nucleocapsid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.917
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUM-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE239688_4_v_0_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
STK10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67991
BRD-K41141507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51282
HYCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49202
BRD-K36798110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33659
CAL62	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73357
BRD-K95422706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69921
superficial layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04004
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
380_AP3D1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.70801
1165_CAMKK2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.52651
BRD-K30318008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0841
Kidney Chromophobe_KICH_TCGA-KN-8437-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DYNLL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49745
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DM-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6933-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
testicular lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.915139
dorsal thalamus_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.973838
TEX261	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38809
BRD-K27476975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4396
BRD-A44046220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18078
BRD-K09337184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02051
Liver cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
exploited	GeneRIF Biological Term Annotations	1.0	null
CRCGN015_HEPG2_48H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.83856
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-A8CQ-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chondrosarcoma	GeneRIF Biological Term Annotations	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44781
musculoskeletal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.060943
BRD-K90736603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29285
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A42Q-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EFNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96275
carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.729762
BRD-K59185421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30853
BRD-K97641878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01476
BRD-K61909412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14053
PAXX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36064
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.868
fulvestrant-5598	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN016_MCF10A.WT.HP_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.78455
SK-MES-1	COSMIC Cell Line Gene CNV Profiles	1.0	3.12177
SP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.73821
hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.246448
skin hemangioma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.485505
BRD-K10820981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56094
BRD-K04853698_LDN-193189_HS578T_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K61551681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08386
IM-9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.644
BRD-K94439911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10921
against	GeneRIF Biological Term Annotations	1.0	null
FEM1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21144
HCC2998	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.40619
U-266	GDSC Cell Line Gene Expression Profiles	1.0	1.69732
RERFLCAD1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.91893
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5356-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8948659-ADVS-9-2104491-s013.xlsx-Sheet1-Supplemental_Table_9_related_to_Figure_7_Differential_genes_highly_correlated_with_TP53_deletion_in_H929_cells_by_RNA-seq_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
mhc class i protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.228108
B-lymphoblastic leukemia/lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
3447_GNL3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.510754
BRD-K41430692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15591
Epithelioma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.59405
Bone marrow cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.949
BRD-K42789863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4316
BRD-K72098339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17417
PMC10625120-ADVS-10-2304638-s002.xlsx-Table_S6-Table_S5_The_RNA-seq_of_KLF5_in_OVCA420_cells_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K60076175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54789
melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.734622
cd4positive	GeneRIF Biological Term Annotations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-S5-A6DX-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CANX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12012
Bladder Urothelial Carcinoma_BLCA_TCGA-E5-A4U1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K95488294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40594
TestisSeminiferousTubule	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.28031
PBRM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62681
Chondrosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.89
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7416-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CX-7086-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cervix uteri	GTEx Tissue Gene Expression Profiles	-1.0	-0.910249
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K86762131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00058
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
x chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.535772
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
DNMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25256
Multiple myeloma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.026
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.4145
GDPD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.66328
CRCGN016_MCF10A.TP53.M_24H:B18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40488
ZNF398	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13524
SPDEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6179
bae1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.935
ZNF710	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7631
TUSC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9587
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A1OC-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.00717
H3K27me3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K94258680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00669
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
four	GeneRIF Biological Term Annotations	1.0	null
Microtubule cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Sarcoma_SARC_TCGA-K1-A6RV-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MOLM14	DepMap CRISPR Gene Dependency	1.0	7.22204
leads	GeneRIF Biological Term Annotations	1.0	null
more	GeneRIF Biological Term Annotations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-3771-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
likely	GeneRIF Biological Term Annotations	1.0	null
IRF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31248
endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063656
SREBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.5557
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A0YX-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Car cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.832
NRF1	JASPAR Predicted Transcription Factor Targets	1.0	null
NCIH841	CCLE Cell Line Gene CNV Profiles	-1.0	-2.55661
PSME2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07722
Lung adenocarcinoma_LUAD_TCGA-44-6778-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A67697194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09178
GSE202434,GSE202438_15_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cell envelope Sec protein transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.524
CRCGN017_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1194
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.865577
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.184
upregulating	GeneRIF Biological Term Annotations	1.0	null
BRD-K54660148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23392
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.619134
T3M3	DepMap CRISPR Gene Dependency	1.0	3.96195
PANC 02.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13238
BRD-K34858602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29925
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.688
FOS_01_99	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59981
MZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18579
cd4	GeneRIF Biological Term Annotations	1.0	null
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K69659917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12617
BRD-K71839680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06018
4871_MAX_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.543898
MERO25	DepMap CRISPR Gene Dependency	1.0	2.86936
GSE148657_3_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
estradiol_mus musculus_gpl4134_gse23241	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NY	GDSC Cell Line Gene Expression Profiles	1.0	1.42598
BRD-K00767817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12348
TFAP2A	JASPAR Predicted Transcription Factor Targets	1.0	null
monoclonal gammopathy of uncertain significance	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.252774
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
RCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27289
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20753
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045884
BRD-A85231803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76018
OTUD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06923
BRD-K76125116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7441
skin benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.1936
Epithelial Ovarian Cancer	DisGeNET Gene-Disease Associations	1.0	null
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.702916
GSE153871_5_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
COLO 794	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.868756
BRD-K37387086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92382
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JG-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HS695T	CCLE Cell Line Gene CNV Profiles	1.0	1.53657
SETDB1	ENCODE Transcription Factor Targets	1.0	null
VMCUB1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.7829
EJM	CCLE Cell Line Gene CNV Profiles	1.0	1.63052
non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.076032
organism form	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
propoxycaine-6803	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
translated	GeneRIF Biological Term Annotations	1.0	null
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
6148_PCYT2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-1.1845
NCI-H460	GDSC Cell Line Gene Expression Profiles	-1.0	-1.46021
BRD-K65933652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39701
CRCGN015_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.64302
Esophageal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.496
RARG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98139
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	153.131
PROM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26903
BRD-K64862162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00052
ACF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.594
TBX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9043
CHLA266	DepMap CRISPR Gene Dependency	1.0	3.20365
DMRTB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24625
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.9262
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JAK1_knockdown_160_GSE37012	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.80329
BRD-K69468381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02737
FOXR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40446
4944_MED21_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.523631
melanoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
mp9	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.047
eye and adnexa disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040537
ctag2	GeneRIF Biological Term Annotations	1.0	null
TCF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.2362
HMCB	CCLE Cell Line Gene Expression Profiles	-1.0	-1.80873
GSE216988,GSE216989_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.671
CTCF_LNCaP clone FGC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TO175T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55585
urinary bladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.499997
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.7792
NCI-H2291	GDSC Cell Line Gene Expression Profiles	-1.0	-1.50711
skin cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Meningioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.688
USB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14415
608_ATF5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.526544
CBS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00766418
DPYSL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4994
BRD-K73830970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61717
BRD-A57762296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22356
hippocampus (hippocampal formation)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.15142
penile cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.659215
6632_PPIL4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.656705
non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
HLCS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92098
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.926539
BRD-K83194053_4-(2-(6-chloroquinazolin-4-ylamino)ethyl)phenol CU-00000000029-2_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
posteroventral (inferior) parietal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.964849
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.942373
JEG3	DepMap CRISPR Gene Dependency	1.0	7.12192
alpha-beta T cell receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.062
496100654_HIP_no dementia_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	13.0672
GSE202434,GSE202438_9_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19F-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1143	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.92855
Esophageal varix	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.192
BRD-K11581306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36449
BRD-K84846130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15825
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.054
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	205.315
melanoma	GeneRIF Biological Term Annotations	1.0	null
HUH1	CCLE Cell Line Gene CNV Profiles	1.0	1.56097
RCM1	DepMap CRISPR Gene Dependency	1.0	6.6366
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CTCF_GM20000_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.503
lateral reticular nucleus (principal part)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02605
KP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19899
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.62396
HCC78	DepMap CRISPR Gene Dependency	1.0	4.6048
TAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80961
small intestine	GTEx Tissue Gene Expression Profiles	-1.0	-1.59396
healthy	GeneRIF Biological Term Annotations	1.0	null
C19orf12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77718
epidermis	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC10082046-41467_2023_37049_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_3_Genes_downregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
Transverse filament	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.735
Perturb_11405_KD_RB1_SRP099582	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.3104
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
esophagitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.41727
BRD-K65887908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10941
vaccine	GeneRIF Biological Term Annotations	1.0	null
MOK	Kinase Library Serine Threonine Kinome Atlas	1.0	null
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.565
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
given	GeneRIF Biological Term Annotations	1.0	null
spleen	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.111633
BRD-K97617600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20107
Rectum adenocarcinoma_READ_TCGA-F5-6810-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K57782577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01981
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.585
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.347
Diffuse large B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.145
RERFLCSQ1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.58152
BRD-K14392329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.43745
together	GeneRIF Biological Term Annotations	1.0	null
imatinib_homo sapiens_gpl96_gds3044	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.619029
Adenofibroma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
SCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95526
HDAC2	ENCODE Transcription Factor Targets	1.0	null
brain cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.084447
BRD-K09146396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08763
outer CP in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.980106
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.954135
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.351
A101D	GDSC Cell Line Gene Expression Profiles	1.0	2.09936
8438_SRSF7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.526019
BRD-K71253424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11143
Synovium cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.144
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.637594
BRD-K23506413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61786
gossypol-6058	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
gonad	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.76425
GSE238116_1_v_0_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
COLO-320-HSR	GDSC Cell Line Gene Expression Profiles	1.0	1.62298
RBE	DepMap CRISPR Gene Dependency	1.0	2.407
A101D	CCLE Cell Line Gene Expression Profiles	1.0	2.84004
BRD-K66577743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62989
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.789399
ZNF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.4706
integument	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
placenta	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.338
2313_DNM2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.652475
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.512239
lage1	GeneRIF Biological Term Annotations	1.0	null
hepatoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
homology	GeneRIF Biological Term Annotations	1.0	null
epidermal cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hecogenin-7175	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
DLX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73129
PARPBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.46968
CNOT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.585
BRD-K59843356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11657
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3265
BRD-K29418729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14914
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052894
GSE130396_0_v_2_braf_human	RummaGEO Gene Perturbation Signatures	1.0	null
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.892069
NCIH1693	CCLE Cell Line Gene CNV Profiles	1.0	2.16863
BRD-K19645475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1108
bladder carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.159302
indusium griseum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.03128
non-membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.522
NCI-H596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.995489
CAMLG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83653
SG in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.84739
MKN45	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46835
TC205	DepMap CRISPR Gene Dependency	1.0	3.20253
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.564035
DDX27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76455
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3203
TUHR10TKB	CCLE Cell Line Gene CNV Profiles	1.0	1.40892
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.39605
SCMH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12993
BRD-A36267905_NYLIDRIN HYDROCHLORIDE_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
investigate	GeneRIF Biological Term Annotations	1.0	null
8923_TIMM44_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.590376
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.870798
immunodominant	GeneRIF Biological Term Annotations	1.0	null
GSE193258,GSE193259_9_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
9909_XRCC6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.535113
gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K43414987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76015
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3395
MSTO-211H	GDSC Cell Line Gene Expression Profiles	-1.0	-1.70122
Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
HES5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5893
BRD-K56653679_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
GSE182179_5_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K22670776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53647
antitumoral	GeneRIF Biological Term Annotations	1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.825
AZI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3671
YAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08865
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17924
ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.192344
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.645713
9478_UBA1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.648508
5732_NOL10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.579253
protein binding	GO Molecular Function Annotations 2015	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.865816
BRD-K46549154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55467
CRCGN008_HEPG2_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.78068
trans-Golgi network transport vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.792
BRD-K41289356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4082
BRD-K64632606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37575
since	GeneRIF Biological Term Annotations	1.0	null
CRCGN012_HEPG2_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9503
BRD-K74512976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29032
snps	GeneRIF Biological Term Annotations	1.0	null
MYCN-21190229-SHEP-21N-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17539
BRD-K21996189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28696
TYK-NU	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LOU-NH91	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01487
BRD-K94616959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15763
NCI-SNU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LCLC-103H	GDSC Cell Line Gene Expression Profiles	1.0	1.79835
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.826465
SKNAS	CCLE Cell Line Gene Expression Profiles	1.0	1.81799
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.548
bone cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081065
ZFAND5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60405
orbital frontal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.61592
squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.64577
BC-3	GDSC Cell Line Gene Expression Profiles	1.0	1.52168
BRD-K84260700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02173
posteroventral (inferior) parietal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09926
9587_UMPS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.633508
ZNF148	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	236.43
MZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.64904
BRD-K52373514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22342
GSE239688_2_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CWR22-Rv1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.513
PMC9424213-41467_2022_32537_MOESM5_ESM.xlsx-HeLa_IER3-AS1sh_DEGs-DEGs_in_HeLa_IER3-AS1sh_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5031-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE121043_0_v_1_aldh1a1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
U-266 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.698
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
Melanoma	DisGeNET Gene-Disease Associations	1.0	null
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00745
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.04999
intracellular non-membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
amygdaloid complex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.3712
BRD-K97921950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27183
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	178.818
SW948	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40574
skin cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.292436
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.12698
QSER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70651
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K06895174_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SW1116	DepMap CRISPR Gene Dependency	1.0	2.60033
been	GeneRIF Biological Term Annotations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J7-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1187	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.24568
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null