association	dataset	threshold value	standardized value
HB-24-GP45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.294076
PMC8901773-41598_2022_7986_MOESM6_ESM.xls-T_vs_LPS-gene_symbol_ENSEMBL_gene_ID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE81193_0_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211177,GSE211178_4_v_10_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CAL51_BREAST	CCLE Cell Line Proteomics	1.0	2.49591
2205_DHX29_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.611212
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.859073
GSE223893_11_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241969
GLDC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00485756
MCF7_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145158
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.66844
WHIM syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
X-linked chronic granulomatous disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.624
Cellulitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
BRD-K95501793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58536
SF3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47493
BRD-K67442425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01815
Disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Extrapulmonary tuberculosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.11
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.5234
GSE151829,GSE151831_7_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K17749779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5201
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220695
GSE222758_0_v_2_clofazimine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DE-99-OT37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20442
GSE203308_7_v_5_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE218949_0_v_1_cep20_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K66838902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92498
GSE186483_2_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7220941-41598_2020_64431_MOESM2_ESM.xlsx-WS1_2019_Affy_IDs_RA-STvsOA-ST-Unnamed_2_PAX3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K68298468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72591
CRCGN011_HEPG2_24H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00425
GSE191021_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K67980271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03954
GSE88819_0_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-05-MR83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.01166
respiratory burst after phagocytosis	GO Biological Process Annotations 2023	1.0	null
CRCGN015_HEPG2_48H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20588
CRCGN008_HEPG2_24H:A21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1479
MCF7_Resveratrol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162638
PMC12786305-ADVS-13-e12620-s001.pdf-44-IRF9_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
NADPH oxidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.288
BRD-K75807957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29869
BRD-K69826976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62679
PHLPP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23113
BRD-K98639224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11329
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.72952
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.77479
GSE158834_2_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226584,GSE226589_2_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
13_AARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.528719
GSE213588_10_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Familial hemophagocytic lymphohistiocytosis 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.136
GSE203485_1_v_0_sunitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.347727
GSE223893_4_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Transmembrane actin-associated (TAN) line	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.756
GSE238116_1_v_0_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8355885-gutjnl-2020-320652supp004.xlsx-RALY_KD_mRNA-seq-Table_3_RALY_Knockdown_in_HCT116_cells_mRNA-seq_log2_FC_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCFL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.7999
GSE133213_6_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5058748-oncotarget-07-31177-s002.xlsx-ZNF224_gene_peaks_promoter-Table_S3_Genes_that_contain_a_ZNF224_enriched_region_within_1_kb_of_the_transcription_ZNF224	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K71391283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24286
TMED7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49979
OTX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7416
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.48146
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-10.3496
GSE110178_2_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE228413_2_v_5_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19038
PMC10534007-Table_3.xlsx-S8_unique_down_MSC_V-345_elements_included_exclusively_in_VMCUB1_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
SIMA	DepMap CRISPR Gene Dependency	1.0	2.44547
BRD-K61092554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15527
AC-84-QG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.814193
GSE228106_3_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CCL18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00663771
BRD-K11782435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13928
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.674
GSE241701_1_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9753996-jci-132-160767-s182.xlsx-IRF4_assciated-ABCA7_IRF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE192513,GSE192515_1_v_0_atg16l1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE161170,GSE161268_0_v_2_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Omenn syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.141
Autoimmune hemolytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.604
PMC8995879-Table_1.xlsx-exome_variants_MAF_0_01-Gencode_34_hugoSymbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
VA-48-RJ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266273
CRCGN017_MCF10A.WT.HP_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19045
Aspergillosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.478
A549_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019998
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.155
GSE215086_5_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Ellagic acid_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128326
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.39
HEY1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9989
PMC6138936-13059_2018_1512_MOESM2_ESM.xlsx-SE_H1-_MSC-Gene-symbol_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE223008_6_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.846145
MCF7_Maraviroc_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154396
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE44157,GSE44163_3_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146074_9_v_11_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mumps	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.04
ADAMTS16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06366
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.520883
GSE214823,GSE214824_0_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
6017_P2RY1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.535797
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.9093
MCF7_Trametinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012603
ARFGAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1525
GSE189683_3_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LA-42-ER00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330537
SAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19188
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.5431
BRD-K57323824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24624
BRD-K47511177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24848
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.611
BRD-K45811188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02012
CRCGN017_MCF10A.WT.HP_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.054
Hyperimmunoglobulin syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
BRD-K45044525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60293
GSE146982_4_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125211_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K26373865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3133
REL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5882
GSE216273,GSE216292_0_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-17q25_3_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K94921631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08114
BRD-K80888333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10517
GSE186280_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2221
PMC10245467-mmc3.pdf-259-ZNF701_ZNF701	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139473
ZNF229	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02025
BRD-K94742710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24863
BRD-K33497830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23636
BRD-K28932860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15327
GSE240386,GSE242143_8_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226091,GSE226092_0_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.22932
GSE162892_3_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11627398-pone.0315219.s005.xlsx-MTF1-symbol_MTF1	Rummagene Transcription Factor Associations 2026	1.0	null
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.4045
CRCGN015_HEPG2_48H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19004
BRD-K23427500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28186
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.31038
7507_RPS18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.535746
BRD-K48755012	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01195
Chronic granulomatous disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
AE-22-QI24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.306695
HD-18-YL30_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.253224
BRD-K84178479	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06874
PD-11-LM65_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23693
Cell junction	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.486
t62-spleen_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	3.26412
GSE114013,GSE114014_1_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.54375
SKA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30485
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.735627
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.69021
PF-39-DY68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.398094
BRD-K11577431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13531
BRD-K22246901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0858
K562_Bisindolylmaleimide IX_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178484
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.30475
496100505_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.03295
PMC12478272-mmc1.xlsx-Table_S7-Supplementary_Table_7_Proteome-wide_MR_and_sensitivity_analysis_results_using_the_brain_pQTL_dataset_from_Wingo_et_al_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.40873
GSE154081_3_v_0_sildenafil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_PJ34_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141856
GSE102505_4_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE200099_3_v_1_honokiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:B12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0665
BRD-K39913135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15349
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.22759
CRCGN009_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.94626
Sulfamethoxazole allergy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.583
BRD-K96438475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27658
GSE107956,GSE107957_0_v_1_ythdf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ebf2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.8302
BRD-K67632894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22315
BRD-K53388755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12524
BRD-K52383401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75553
PRKCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10463
PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-Normal_309_TCF7_rep1_sorted_pea-Gene_Name_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE143643,GSE143644_1_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199204,GSE211619_4_v_7_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K56590597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77582
GSE208254_3_v_1_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LD-69-ZV56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229008
UF-06-JB00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.17397
Zygote	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.356
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.55287
A549_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241222
PMC9314667-Table_1.xlsx-Regulons-ELF1_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K26738018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35714
GSE133329_2_v_3_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.81706
GSE130217_0_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cryptosporidiosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.973
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.717411
BRD-K52582315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07157
GSE129858,GSE129859_1_v_3_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE138019_4_v_5_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE221004_3_v_2_prdm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187443
BRD-K40494117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02301
NIPSNAP3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2082
BRD-K35616138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04307
FARSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48068
Trichosporonosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
PA-15-CP52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205207
GSE165122_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K19523037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24827
Phagocyte bactericidal dysfunction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.932
CRCGN015_MCF10A.WT.HP_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13266
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_2_KD_HeLa-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K32477623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15347
AF-41-QY60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.375084
EE-08-SZ54_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.441918
BRD-K26552461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67474
Sporozoan form	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.429
GSE95077_1_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE138050,GSE148257_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_PJ34_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154539
decreased total body fat amount	MGI Mouse Phenotype Associations 2023	1.0	null
Lung abscess	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.604
GSE140200_1_v_3_trim59_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Endomembrane system	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN017_MCF10A.WT.HP_24H:C09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4967
GSE216273,GSE216292_14_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_WHI-P154_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140109
CJ-42794	DeepCoverMOA Drug Mechanisms of Action	1.0	0.37
GSE202434,GSE202438_7_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE131649_2_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BA-40-IU73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245515
BRD-K20426211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20157
MAGEE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25585
GSE233049_2_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.637
GSE48812_7_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
IE-80-DC24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233785
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE196117_6_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Chronic granulomatous disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.97
BRD-K16044155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39548
GSE198165,GSE198166_6_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Protein quantitative trait loci	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.639794
BRD-K57937572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0082
BRD-K85398599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78226
BRD-K27540772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61242
BRD-K51843685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51616
Parasitic infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.164
NVL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03806
GSE190186,GSE190188_0_v_10_apoe_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K91585756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1398
BRD-K30597925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17265
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.1918
CRCGN015_MCF10A.TP53.M_24H:L21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8452
TBX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00469849
GSE161170,GSE161268_1_v_3_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FF-89-KK36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216781
BRD-K20119884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24757
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K37592272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91218
PMC9904760-elife-79363-supp2.xlsx-MDS1-Gene_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
NB17	DepMap CRISPR Gene Dependency	1.0	4.75355
BRD-K84457681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17225
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
UBB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00356691
BRD-K58277621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08675
Sulcotrione	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
GSE128333_4_v_1_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE175787_11_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K37433647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38192
MCF7_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174284
HEP3B217_LIVER	CCLE Cell Line Proteomics	1.0	3.85848
GSE122711_1_v_0_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K53643174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01865
BRD-K73048554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77631
TUSC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10999
GSE182680,GSE182683_5_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Primary bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.28
MED31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12086
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-11.0306
BRD-K01225799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01052
Opportunistic mycosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.49
BRD-K40851366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28135
GSE123943_4_v_5_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.00115
GSE178255_1_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.2233
NDUFB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13188
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE136894_1_v_3_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Apicoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.615
chr17_82444070_A_G_b38	GTEx eQTL 2025	1.0	3.68164
FC-85-OX77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.65871
GSE164483_2_v_0_venetoclax_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
2622_EMG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.542524
BRD-K47636083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38036
AC-50-FR41_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226112
GC-07-UO80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224578
BRD-K73969016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05824
BRD-K96737756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19577
t62-spleen_male_8w	MoTrPAC Rat Endurance Exercise Training	-1.0	-2.7545
CRCGN013_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.15974
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-9.26915
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A_48H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05534
BRD-K85307083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98974
CRCGN013_HEPG2_24H:N13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70549
BRD-K02334683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52006
GSE143643,GSE143644_3_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Paralytic squint	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
GD-46-BU97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.390785
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9748
BRD-K65887908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71571
GSE103068_5_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lymphadenitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.921
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.144
GSE196117_1_v_8_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
DHFR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21788
KIF3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5429
GSE148066,GSE157787_9_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K62555617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47367
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.876856
GSE192513,GSE192515_2_v_0_atg16l1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Tofacitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158693
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.89359
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0652
JC-02-ZR15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229056
GSE196699_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.71046
BRD-K42150052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28996
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.17534
MCF7_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164945
PMC7220941-41598_2020_64431_MOESM2_ESM.xlsx-WS2_2019_Affy_IDs_SignalsQN-Unnamed_2_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Oocyst	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.731
BRD-K10276373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28852
BRD-K96320811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13357
MON	DepMap CRISPR Gene Dependency	1.0	2.77483
GSE122215,GSE122217_5_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151494_1_v_4_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXA1-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE252958_1_v_0_znf469_human	RummaGEO Gene Perturbation Signatures	1.0	null
LRATD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36742
GSE178227_1_v_2_tet1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE228413_4_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K63024248	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51803
859_BMS1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.599927
PPARA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08692
AA-98-MW52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242776
SKA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06039
BRD-K37015376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92977
AE-67-FF84_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204346
A549_AC480_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191067
GSE211177,GSE211178_4_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain stem	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SNU1_STOMACH	CCLE Cell Line Proteomics	1.0	2.55504
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201042_2_v_3_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE190186,GSE190188_0_v_5_apoe_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF-_SURVIVAL-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.031
GSE158834_10_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE122215,GSE122217_5_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FC-19-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.253031
GSE231720,GSE231724_2_v_0_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Amp_AA-TCGA-Unnamed_20_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K37062347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11961
GSE214823,GSE214824_4_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233965
AB-84-PK04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20321
GSE215086_0_v_1_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
6724_PRDM15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.55832
BRD-K99077411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00754
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_2_KD_HeLa-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Plagl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.8373
BRD-K14868348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30272
BRD-K74632893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21748
CRCGN015_MCF10A.TP53.M_24H:I05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14667
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Up_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K19567079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90698
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-Row_names_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
EXD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17809
GSE149943_2_v_0_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mouth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
CRCGN014_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18183
Hypersensitivity reaction type IV disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
GSE179036_1_v_0_trim24_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_UNC0379_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00858784
CRCGN012_HEPG2_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6972
BRD-K79887735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07852
GSE202744_1_v_3_toyocamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K21466747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99758
GSE77108_0_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_10_v_6_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Miliary tuberculosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.465
BRD-K02374169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42629
CRCGN014_HEPG2_24H:L05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05016
CE-95-YX02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240984
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.533555
NCIH2126	DepMap CRISPR Gene Dependency	1.0	2.28996
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.630114
Photosystem I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.975
GSE213588_9_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K48541282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56671
GSE248770_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Flavopiridol HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127588
GSE179880_7_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.807483
CRCGN017_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.95535
BRD-K85336956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14399
CRCGN015_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2583
A549_Mercaptopurine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156808
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.2056
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-8.09485
MCF7_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147511
GSE175787_5_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE237040_6_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NF-21-HQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.93174
BD-60-DR81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243363
OCUG1	DepMap CRISPR Gene Dependency	1.0	2.18631
BRD-K23666684	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78942
PB-18-HD85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.597343
Intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE60217_1_v_0_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178255_1_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.16107
BRD-A25184723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57775
GSE161184_0_v_1_tlr7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1131
CMTM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04722
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.94028
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.507753
BRD-K39692099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02732
Lupus erythematosus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.236
WDR12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18842
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6918
BRD-K47599661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03128
GSE179002_3_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXA10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00456015
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.862697
BRD-K18332967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30114
BRD-K98020844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57315
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE92434_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.372927
PMC3435504-msb201237-s2.xls-Supp_Table_4c-STAT1_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.04007
CHLA57	DepMap CRISPR Gene Dependency	1.0	8.71743
AC-28-RT00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24329
RH30_SOFT_TISSUE	CCLE Cell Line Proteomics	1.0	4.32937
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.795203
GSE148200_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE166920_6_v_1_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE220693_1_v_0_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
C8166	DepMap CRISPR Gene Dependency	1.0	4.92749
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.553451
A549_Roxadustat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184107
GSE216538_7_v_2_mrs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1857
BRD-K80766355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23125
GSE148066,GSE157787_8_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_triplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K82105167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59494
GSE124410_3_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Celecoxib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179966
GSE229309,GSE229314_4_v_1_elavl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Merozoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.332
GSE180200,GSE180201_3_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K28531276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19414
PMC7806814-41598_2020_80145_MOESM3_ESM.xlsx-CombinedResults_TreatbySexMainE-Supplementary_Table_S2_Genes_with_significant_FDR_0_05_sex_by_LPS_treatment_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K32131036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47859
SA-32-CC58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222239
BRD-K03697080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03921
MOLM13	DepMap CRISPR Gene Dependency	1.0	2.48319
KA-51-CQ55_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238764
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF_D1_vs_D10-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_11_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
STAT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.1934
SA-32-CC58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.469006
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30218
GSE171175,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
B-lymphoblastoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.099
BRD-K59356638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3604
GSE112761,GSE112767_4_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IA-27-CK10_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269823
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.25028
GSE165307_3_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180200,GSE180201_3_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K04470135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0667
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Severe combined immunodeficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.263
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.7789
ZSCAN21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9683
CD-35-BD44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.43291
BF-94-CQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223503
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.961039
GSE148066,GSE157787_5_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K25423143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.95495
PABPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.424
MCF7_Capecitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135254
BRD-K38604123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2253
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_14_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
chr17_82444169_T_C_b38	GTEx eQTL 2025	1.0	1.79454
Chromosomal deletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
10569_ZNF705B_ENST00000443676.1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.525195
BRD-K29649571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26013
MCF7_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017925
BRD-K92928918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27443
CRCGN009_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33752
GSE146074_10_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03293
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE133683_1_v_5_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.25478
BRD-K31297909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13074
BRD-K01317665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0605
GSE188570,GSE188571_3_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE166536_1_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
XD-03-FM54_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201791
PMC9170563-12885_2022_9665_MOESM3_ESM.docx-0-Candidata_target_genes_of_CEBPB_1_CEBPB	Rummagene Transcription Factor Associations 2026	1.0	null
LF-85-QP07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21463
KINGS1	DepMap CRISPR Gene Dependency	1.0	4.85705
GSE158834_11_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K24599650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24699
Invasive aspergillosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.399
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.2956
BRD-K06403738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.182
PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_1_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9273
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE206226_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_10_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-09-EA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26953
BRD-K38719699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09981
GSE223008_6_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NUP93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85242
ZIM3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5379
MCF7_UNC1999_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014752
GSE182181_1_v_0_ricolinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Normocytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.134
BRD-K82115725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39363
BRD-K39600742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27051
MCF7_Lomustine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149656
BRD-K76067434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64319
GSE172295_3_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE217115_2_v_4_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10572
PMC8410861-41467_2021_25544_MOESM32_ESM.xlsx-MCR-MCR_cells_-_DGE_iGCA_testis_vs_adult_testis_from_GSE112013_and_GSE124263_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE175787_13_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KCNN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21073
GSE162892_3_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
MTR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58475
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_x_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K28184331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1076
MARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91522
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.33181
BRD-K66577743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07773
BRD-K29898553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10433
Autosomal recessive chronic granulomatous disease 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.807
ID-00-IC14_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.315581
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.860639
BRD-K57205873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18233
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.346074
BRD-K79768278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03751
BRD-K81082554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1473
decreased bone mineral content	MGI Mouse Phenotype Associations 2023	1.0	null
CTV1DM	DepMap CRISPR Gene Dependency	1.0	2.13835
HCC1395_BREAST	CCLE Cell Line Proteomics	1.0	3.16618
Awn	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.284
HCT-8 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.56
4944_MED21_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.692488
AC-91-AV48_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218746
A549_Trametinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00873003
E2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.8934
GSE110248_1_v_6_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE199874_4_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.39517
BRD-K34009761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9417
PMC6137307-mmc2.xlsx-IRF9-IFNa-Table_S1_IRF9-IFNa_Related_to_Figure_1_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_EC_CSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K77892726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2681
BRD-K63859730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22516
A549_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148787
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PPP1R15B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39962
WF-85-JN16_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237561
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.973565
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.53515
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.23144
CRCGN012_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.51874
BRD-K81277520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32784
ZNF341	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8168
GSE216043_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
IREB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10391
4470_KRI1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.508703
BRD-K51253991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63313
BC-62-RZ55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.435132
GSE218356_1_v_0_cited1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K12833024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10785
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.40369
A549_Momelotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118161
BRD-K45592944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03958
MCF7_Divalproex Sodium_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171381
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.12054
GSE240258_0_v_1_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K59434830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0969
A549_Obatoclax Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135686
CA-42-YI34_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250383
E2F5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08015
FD-20-OG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.308529
A549_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200763
8505C_THYROID	CCLE Cell Line Proteomics	1.0	4.32937
YF-47-HO48_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215933
CRCGN014_HEPG2_24H:G03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17543
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2313_DNM2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.516928
BRD-K56223790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.30983
BRD-K34028745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22038
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_hexaplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
EFEMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27484
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210383
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.91206
BRD-K29120026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41775
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.25367
BRD-K70127757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00018
GSE148252_7_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10172325-41598_2023_34728_MOESM5_ESM.xlsx-KD_Upregulated-Unnamed_0_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213650_0_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.498
GSE60217_1_v_2_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JD-44-KF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.01193
GSE212486,GSE212488_2_v_3_gata4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DC-47-KV62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257641
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE130396_8_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ACAA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25331
BRD-K56150975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16546
CRCGN015_HEPG2_48H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.63862
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.45572
BRD-K74486924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33028
MCF7_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0102042
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.08328
BRD-A40022950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41375
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EIF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65759
GSE167886_2_v_0_chd7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE137818_5_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE215351,GSE215794_2_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.30914
BD-18-MM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206278
3572_GTF2F2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.568727
ZBTB11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07125
HCC1395	DepMap CRISPR Gene Dependency	1.0	3.5457
BE-82-TS38_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.371118
BRD-K20215591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11432
Spikelet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.834
BRD-K34957967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25986
CRCGN016_MCF10A.TP53.M_24H:M12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23463
PMC4682820-pgen.1005734.s014.xls-STAT3_targets-Unnamed_0_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221356_1_v_0_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K99859971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95893
GSE89018_6_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160246_9_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.122
BRD-K81450614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14914
ZD-85-ND87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.492213
Mlg	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.778
Cytotoxic T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.122
NDUFA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26887
GSE158834_11_v_5_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193993_5_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE138841_0_v_1_trim6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.199
GSE179974_3_v_4_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K85200795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86645
KIR2DL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00396785
BRD-K63111122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16904
BRD-K09975619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09742
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.91214
BRD-K34595616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.203
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.79997
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K89637993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.42165
GSE130383_2_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SOGA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04764
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Avagacestat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152148
GSE182680,GSE182683_10_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLF10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	103.245
EIF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05297
PMC6137307-mmc2.xlsx-STAT2-IFNa-Table_S1_STAT2-IFNa_Related_to_Figures_1_4_STAT2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K02060635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74952
LS1034	DepMap CRISPR Gene Dependency	1.0	2.26835
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.8498
GSE84148,GSE96938_0_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K27139040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89301
BRD-K74611044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.62108
GSE196699_2_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TC205	DepMap CRISPR Gene Dependency	1.0	4.95084
GSE135352_2_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ce92	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.261
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.445034
Helper T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.122
BRD-K42828928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01156
BRD-K14258088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17071
GSE128076_2_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K59335919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14131
GSE171572_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_PF-573228_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145574
AB-17-WP43_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.45507
BRD-K37144511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75263
DE-73-JX23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.437708
GSE225218_0_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K68574010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.468
CF-24-KQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21873
HF-91-IU60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.476031
GSE146074_10_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K75989234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29438
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.31442
BRD-K92949288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09801
Systemic mycosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.516
EB-67-WB79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258616
GSE246911,GSE246913_4_v_1_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TD-69-UA90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228993
NC-27-AD53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218815
BRD-K80996561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27829
BRD-K41044903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17961
BRD-K33371292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31726
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_CSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166920_6_v_4_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211177,GSE211178_8_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_5_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4580625-pone.0138726.s006.xlsx-Immune_molecular_modules-PKNOX1_mod_PKNOX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K91239327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07996
PMC9181267-mmc5.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.3404
GSE116810_2_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JMSU1_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	2.80784
GC-74-QF56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21698
DMBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34026
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE224970,GSE224971_1_v_0_sap30_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K43901257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37077
GSE193685_2_v_3_il11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.596889
GSE146982_3_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_6_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135030_3_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ERBB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00263797
AA-22-UI44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.326197
LD-69-ZV56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.419405
BRD-K38189984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09281
PMC9181267-mmc5.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135350_2_v_5_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.8918
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
POR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04604
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212675
BRD-K89660028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.58132
K562_Carmofur_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168652
GSE158834_11_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193258,GSE193259_9_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GC-73-YI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252539
GSE120216_3_v_0_cbfb_human	RummaGEO Gene Perturbation Signatures	1.0	null
AD-86-ES28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226387
BRD-K23361743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74916
BRD-K99078335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14508
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE110268_2_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K23975481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00005
X-linked recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.147
GSE214823,GSE214824_5_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11265
NB10	DepMap CRISPR Gene Dependency	1.0	2.2669
Autoimmune disease of musculoskeletal system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
DC-51-WE27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.43527
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
10400_ZNF497_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.14251
Immunodeficiency 21	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.112
BRD-K08929846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03859
GSE140322_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE248045,GSE248046_0_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GE-63-WI86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.356145
KYSE220	DepMap CRISPR Gene Dependency	1.0	2.73068
BRD-K81293413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24953
CTCF-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
HPDL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2502
ELP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37367
BRD-K74712962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13493
BRD-K02602127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03989
BRD-K72424071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51442
CRCGN008_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13885
GSE94849_6_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K13873561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1118
Disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
MATN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24143
BRD-K02269304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29096
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.125
GSE146982_4_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
2084_DCXR_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.607761
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9967
BRD-K25304254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32101
BRD-A51381734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06831
BRD-K57476199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59188
BRD-K36852613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43411
BRD-K35469110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11085
TBC1D10A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66846
GSE152432_5_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KLF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.396
FA-92-JL46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.287761
Primary immunodeficiency disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.51267
Sporozoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.736
GSE216043_10_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FF-54-JC89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212489
BRD-K93693615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16407
GSE239844_4_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.94345
BRD-K43909206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18053
BRD-K75168124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2342
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.967663
FA-88-II68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.454303
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K30823221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32942
GSE88819_0_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8744330-13024_2021_507_MOESM2_ESM.xlsx-Table_S5-Supplementary_Table_5_The_conserved_3-layer_neighborhood_of_TP53_in_the_co-expression_networks_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE44157,GSE44163_1_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.67726
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.24953
BRD-K41033343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56245
STAT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.7793
BRD-K27616003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16642
GSE223008_9_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
5738_NOL9_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10679
BRD-K40252598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03754
GSE158834_11_v_6_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160083,GSE160084_1_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K31408750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15059
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.91207
GCM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0718
GSE207787_3_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K37741838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15273
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8807392-41375_2021_1393_MOESM2_ESM.xlsx-data_integration-YBX1_iCLIP-targets_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K56520129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64483
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
D542MG	DepMap CRISPR Gene Dependency	1.0	3.27396
MC-51-BT07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274363
BRD-K42575648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53035
BRD-K44152881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44944
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.5821
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.85838
PMC3470785-NIHMS377161-supplement-3.pdf-195-TFDP3_TFDP3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE180789_1_v_0_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-84-PK04_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225476
TRMT1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47854
CRCGN017_MCF10A.WT.HP_24H:B16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17825
GSE193258,GSE193259_9_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K95457967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12309
Legionellosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.175
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	1.0	null
Phagocytic vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.806
KD-36-KT24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.293198
BRD-K09078201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11277
GSE129389_0_v_4_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KLF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	88.8202
BRD-K72386335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.301
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100335_PCx_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.15577
CRCGN014_HEPG2_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2991
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.30227
BRD-K77643021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6579
JHU022	DepMap CRISPR Gene Dependency	1.0	3.7199
GSE184356_3_v_0_tfam_human	RummaGEO Gene Perturbation Signatures	1.0	null
PTK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00358111
Hindbrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K48143921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05207
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	1.0	null
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.24526
BRD-K09432998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24959
BRD-K75177817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13839
FA-92-JL46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212368
BRD-A66025870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08885
GSE182680,GSE182683_10_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148252_5_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K31354456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0895
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-10.2431
GSE145311_1_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K14695950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18513
GSE112761,GSE112767_2_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K70361311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1604
GSE120370_0_v_6_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-ENSG_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
AB-70-GR31_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22129
BRD-K67725403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66257
BRD-K75551005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03779
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.1466
GSE188570,GSE188571_5_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Chromosome 17q12 duplication syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.558
BRD-K52225720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17014
E2F7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04169
A549_G007-LK_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145846
GSE196117_1_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4821877-ncomms10846-s9.xlsx-THP1_Splice_events-Gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
RELA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8889
GSE151782_3_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hemolytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.247
A549_G007-LK_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168877
BRD-K00048792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22671
GSE205316,GSE205317_0_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K28559679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39323
Plasma membrane	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
KIAA1143	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03575
5955_OR4K1_ENST00000285600.4	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.533636
PMC9314667-Table_1.xlsx-Regulons-STAT1_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_PSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K98016463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.59638
GSE136894_1_v_0_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hermansky-Pudlak syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.114
Autoimmune disease of blood	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.425
Mixed receptive-expressive language disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.348
GSE199921_1_v_0_romidepsin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_11_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K91879432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30086
CRCGN011_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2632
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-eTable_38_Cis-instrument_Mendelian_randomizaion_screen_of_1_901_cortical_proteins_on_lifetime_smoking_behavior_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230877
MCF7_Raltitrexed_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183833
CRCGN015_MCF10A_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18705
NB-58-SA13_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.338642
POLR2G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08992
BRD-K63921431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12267
TNFAIP8L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54453
KE-91-GT92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253567
COX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30778
X-linked lymphoproliferative syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.204
AC-30-XU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.418561
PMC7316257-pone.0233899.s011.xlsx-AR_regulated_genes-genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
B cell deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
Fungal infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.547
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.492
BRD-K38972344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17386
H3C6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04077
GSE71674,GSE71676_0_v_2_cbfa2t2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mitosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.104
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.689482
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.880672
BRD-K04336022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33749
CD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00534694
GSE142210_3_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE102132_2_v_1_irf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157555,GSE157556_4_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE88819_0_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Avagacestat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169065
IQCB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25269
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
ATP6V1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12517
PC-62-AQ92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.393882
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.483803
GSE124410_2_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146982_4_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K46655163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33283
Submandibular lymph node	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.035
CHD4-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
Endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE73561,GSE73563_0_v_1_mef2c_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131660_2_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DB-56-XL71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213492
IE-80-DC24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270729
4-Benzylpyridine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.23
BRD-K37315860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55155
GSE196699_2_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211177,GSE211178_0_v_1_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE132386_2_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Andarine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130257
GSE214514_1_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WDR74	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45305
GSE137914_0_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DB-41-IH69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.273673
BB-93-VT73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232058
BRD-K70819166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00662
FA-63-WI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.26141
GSE138863_2_v_0_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE180200,GSE180201_12_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KIF3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00410266
BD-04-NG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.93268
CNN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04657
Kinetoplastid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.977
WC-09-GD62_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265571
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.501337
GSE60217_1_v_9_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BEST4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1301
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_12_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K06863921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1184
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Gene_Name_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K23670243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0217
GSE214823,GSE214824_4_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201217_2_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K42605555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19174
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.0528
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lip disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.16
GSE231720,GSE231724_2_v_1_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K31874013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01885
BRD-K44481920	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11442
ZIC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.6253
GSE130081,GSE130082_0_v_10_neil2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SB-94-ZA83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.312634
GSE154936_3_v_4_remdesivir_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE87412,GSE92423_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165334_2_v_0_dabrafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216273,GSE216292_0_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K27352194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06513
BRD-K21196859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40625
GSE168076,GSE168080_1_v_0_batf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Splenic abscess	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.392
GSE229344_2_v_0_cyb5r3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE221327_6_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213632_3_v_5_acod1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SUDHL8	DepMap CRISPR Gene Dependency	1.0	3.25078
GSE128730_7_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BC-33-BM51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271391
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.251
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K40923781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02946
Lymph node disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.84
NDUFB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40595
DiGeorge syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.071
LOUNH91	DepMap CRISPR Gene Dependency	1.0	2.82598
BRD-K53548223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57123
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.418
BRD-K25075258	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07353
GSE255988_2_v_0_ethanol_human	RummaGEO Drug Perturbation Signatures	1.0	null
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.8587
BRD-K24422491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48355
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.456361
NCIH1993	DepMap CRISPR Gene Dependency	1.0	3.40221
BB-62-MS83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215551
GSE190186,GSE190188_8_v_5_apoe_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148066,GSE157787_8_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dg2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.609
BRD-K67522096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12169
CRCGN013_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.04016
GSE196699_7_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OF-05-CB18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.686327
GSE214514_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.942243
GSE98898_7_v_2_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206516,GSE206518_1_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K79072801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74965
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.07986
DC-49-EJ23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.419904
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.71149
Microneme	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.493
PMC10534007-Table_2.xlsx-S2_overlap_MSC_down_B_V-395_common_elements_in_VM-CUB1_MSC_down_and_BFTC905_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Chickenpox	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
BRD-K11474067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05963
6870_PSMD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.71131
GSE130401_6_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
IGR39	DepMap CRISPR Gene Dependency	1.0	2.91023
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K20138377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46378
SLC25A27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39438
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.581085
PMC12224929-ADVS-12-2416784-s006.xlsx-DEG_circGLIS3_KD-Unnamed_6_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE88819_0_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151829,GSE151831_1_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K01283689	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41335
GSE193402_0_v_3_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TC-95-IR96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285682
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.18242
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.93571
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.548747
CRCGN012_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22733
OVCA420	DepMap CRISPR Gene Dependency	1.0	2.87974
BRD-K26321439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20212
SKA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61101
BRD-K12555854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01247
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.298629
GSE178255_1_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.90708
RPS27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03212
BRD-K88642841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17379
decreased circulating glucose level	MGI Mouse Phenotype Associations 2023	1.0	null
GSE165174,GSE165175_0_v_1_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.73274
GSE204811,GSE204813_1_v_3_trim29_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130715_2_v_3_budesonide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FADU	DepMap CRISPR Gene Dependency	1.0	5.82971
BRD-K52908798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34876
BRD-K38120474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74534
WM2664_SKIN	CCLE Cell Line Proteomics	1.0	3.37413
BRD-K92167240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50883
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.64494
DB-41-IH69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211012
BEST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44672
GSE101537_1_v_3_neurog3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K26994486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73922
SNU213	DepMap CRISPR Gene Dependency	1.0	2.94347
GSE186647,GSE217288_2_v_4_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MHC class II deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.031
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.99091
GSE101537_4_v_2_neurog3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203485_1_v_0_zdhhc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
YC-45-JD42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203804
BRD-K74216068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67542
496100483_FWM_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.27992
decreased circulating amylase level	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K32373560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6733
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.132
GSE213650_3_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
WD-86-NH64_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212342
GSE148252_5_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE95077_1_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hordeolum	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
CRCGN011_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06365
Cpa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.589
BRD-K77246148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33869
GSE120370_4_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.76322
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.58421
GSE148200_3_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165122_0_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K19829092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2385
GSE231799_3_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K69536411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7959
BRD-K42804674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2644
GSE148066,GSE157787_3_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-11-RO46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.671202
BRD-K75595810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03187
BRD-K24396618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48205
BRD-K22039769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03689
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.62808
ME-16-XW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.283891
BRD-K53768630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29144
TIMM23B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74973
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.116
BRD-K04546974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3829
BRD-K43388152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41277
CRCGN016_MCF10A.TP53.M_24H:B18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21148
BRD-K22062326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05984
TAB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75541
BRD-K37480258	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54706
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
Ebf4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.9844
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE125219,GSE125221_4_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193282_3_v_1_cd44_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216043_10_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.78614
BRD-K48266244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12939
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_4_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151782_1_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	122.18
A549_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155041
BRD-K61366105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.22861
LYST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00508966
MCF7_SNS-314 Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148543
Chromosome 17q23.1-q23.2 deletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.571
MDAMB361	DepMap CRISPR Gene Dependency	1.0	3.35995
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.471878
CRCGN017_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.31145
BRD-K39271757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70225
BRD-K32205799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95703
ZNF138	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21556
PMC10897204__F6	PFOCR Pathway Figure Associations 2024	1.0	null
IC-80-CT90_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266322
GSE60217_1_v_10_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-36-SY22_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203807
NCIH1944	DepMap CRISPR Gene Dependency	1.0	2.57718
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
A549_ENMD-2076 L-Tartaric acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163828
BRD-A17658676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56141
AB-96-XV75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23518
BRD-K98005735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.32864
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.02945
Atf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.6091
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.353059
BRD-K13559806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12126
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.1359
EPAS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9781
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.60467
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.514
K562_Cerdulatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181733
AGTR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00457528
RD-90-OY66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.350855
Catalase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.341
AE-64-KN26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272809
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K36135420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55123
8599_SUPT6H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.526497
GSE127790_6_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE166920_6_v_8_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K11247495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27553
MELK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00273403
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.6795
GSE103068_0_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE175787_5_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-9.67903
S0-EE-Y4UM_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.309566
PRPF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.79227
GNA15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00407225
GSE142210_11_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.23398
NFYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3933
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.73644
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2541
A549_SRT3025 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134147
HEPG2	DepMap CRISPR Gene Dependency	1.0	2.17483
CRCGN015_MCF10A.TP53.M_24H:B20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8637
GSE147876,GSE147877_4_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.52848
GSE160246_2_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K59134599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19586
BRD-K36952018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39967
GSE180185_7_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171486_4_v_6_ddx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232593
ND-39-PO34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.57275
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.31461
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.24252
SP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	117.309
GSE248045,GSE248046_6_v_2_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_CCRFCEM_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120336_0_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
7753_SEC61G_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.754114
PLEKHM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00492707
CB-46-FO63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234603
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.4734
GSE215086_5_v_6_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Inflammatory bowel disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.574
EC-98-KI28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.00987
GSE149943_1_v_0_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.34393
GSE188458_2_v_4_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MFE280_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	3.23249
CE-18-CG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222617
BRD-K31889353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44209
S0-EE-Y7IR_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.670732
CCC5	DepMap CRISPR Gene Dependency	1.0	2.21374
chr17_82450472_A_G_b38	GTEx eQTL 2025	1.0	1.85699
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.43058
496100382_PCx_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.04451
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.379221
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.15797
GSE147876,GSE147877_4_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.08651
GSE211177,GSE211178_8_v_10_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GPT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23992
GSE95685_4_v_5_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BE-81-QL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.96089
SDC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31983
GSE166920_6_v_2_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K53050301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72856
GSE123943_4_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K99028283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7138
CRCGN016_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.69462
BRD-K31337291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44013
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.4891
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_U87MG_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K00717406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.51772
BRD-K47804666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18661
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_y_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11982601-IMM-175-84-s005.xlsx-Fig5D_LPS-Innate_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53797069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30465
8-M-PDOT	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35646
BRD-K16954129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61018
CE-15-YU05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229336
Pneumonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.32
GSE123861_1_v_0_sin3a_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K87927290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.2443
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE236486_1_v_2_arnt_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4a-STAT1_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.547775
GSE202434,GSE202438_13_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146762
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE130383_2_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EMC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06077
KPNYS	DepMap CRISPR Gene Dependency	1.0	2.81716
STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER	ChEA Transcription Factor Targets 2022	1.0	null
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.1945
HSFY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27673
SKNFI	DepMap CRISPR Gene Dependency	1.0	2.05364
FE-10-KQ78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.432246
Cellular anatomical entity	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Specific granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.996
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.26585
GSE191037_0_v_1_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K28093873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11736
BRD-K23200057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92268
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.0231
Triclabendazole	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.25
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.127
BRD-K29163534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.4379
GSE88819_0_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
B-lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.099
GD-46-BU97_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252279
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.2139
BRD-K88080911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09397
GSE179974_3_v_5_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K27620386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4121
Chloroplast photosystem I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.574
BRD-K34710061	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16721
GSE201270,GSE201272_5_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Plasma membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.895
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.42284
BF-27-HP68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.402644
Dbf4-dependent protein kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.744
PMC9181267-mmc5.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
PF-39-DY68_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210561
KMS11	DepMap CRISPR Gene Dependency	1.0	2.24848
GSE184884_4_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4944_MED21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.505369
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.39738
AA-58-FJ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.77354
2784_EXOC7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.591796
GSE89018_6_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE95077_1_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TF-77-DW08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240537
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239688_2_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NUP153	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6357
BRD-K36795325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32723
GSE115363_3_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8173714-NIHMS1678410-supplement-Supplementary_Table_2.xls-OfficialIPEXsig-Supplementary_Table_2_-_IPEX_signature_genes_with_their_average_IPEX_HD_fold_change_in_Tregs_and_Tconvs_FOXP3	Rummagene Transcription Factor Associations 2026	1.0	null
U343	DepMap CRISPR Gene Dependency	1.0	3.53236
BRD-K44536345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8626
GSE248045,GSE248046_6_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K40418847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36978
GSE57871_6_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K75410936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.7063
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.07182
GSE210101,GSE210114_7_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199899_4_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151119_3_v_1_hsf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AE-39-DG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.48084
MPIG6B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00685905
BRD-K87269010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5534
Dendritic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.186
BRD-K32362211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0168
MJ	DepMap CRISPR Gene Dependency	1.0	4.74852
BRD-K35792251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35514
GSE149075_2_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K24067917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33449
GSE130396_1_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Cerdulatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137313
BRD-K12226398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61748
PMC11636563-kead628_supplementary_data.pdf-1-BACH2_BACH2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE205070_2_v_5_mertk_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TRIB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10702
BRD-K06147970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42169
SB-228357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08074
ZD-18-MI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.10661
GSE95077_1_v_0_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
XE-18-BC97_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289106
PMC11307286-ao4c01308_si_001.pdf-6-APRF_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K25877330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35908
GSE67266_7_v_3_etoposide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K60454848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13626
A549_Tofacitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132062
GSE178340_7_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.449
RBM17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02571
BRD-K96295480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39089
DGKD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00452823
PMC10172325-41598_2023_34728_MOESM5_ESM.xlsx-KD_Upregulated-Unnamed_7_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN010_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.241
A549_KW-2449_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189562
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8703
CAMA1	DepMap CRISPR Gene Dependency	1.0	2.44042
CRCGN017_MCF10A.WT.HP_24H:P11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2509
GSE160304,GSE163392_4_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
5462_NAPA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.851928
PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K37906141	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80989
McLeod syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.111
GSE207978_1_v_0_rai1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K05253426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72237
AD-55-WK61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234586
Chronic mucocutaneous candidiasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.261
decreased body weight	MGI Mouse Phenotype Associations 2023	1.0	null
CRCGN017_MCF10A.WT.HP_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.87425
CRCGN015_MCF10A.WT.HP_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37014
GB-73-QS80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208285
STAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16191
Follicular lymphoma	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.669897
Parasitic protozoa infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.201
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.26606
CRCGN016_MCF10A.TP53.M_24H:J04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.33318
A549_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145691
BRD-K86300178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.6785
GSE120336_0_v_2_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.54429
IA-76-ZU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345241
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.076
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.717447
Ikzf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.6027
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.47917
Cervical adenitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.498
BRD-K46306993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23805
Phagocyte bactericidal dysfunction	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.26411
GSE160246_0_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
3'-fluorobenzylspiperone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53568
GSE229468,GSE229471_2_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SNAPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05776
Coccidiosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.499
MCF7_IOX2_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190356
Rubella	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.163
GSE144231_2_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_5_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.01217
BRD-K39668479	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7944
GSE160817_5_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.45779
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.54846
Intracellular anatomical structure	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Immunodeficiency 20	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
GSE146894_3_v_8_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K26232524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15176
GSE193258,GSE193259_2_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Alectinib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.53
X-linked monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.09
A549_Hesperadin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142241
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.362
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE227415_1_v_0_ucp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Oral candidiasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
BE-66-UB12_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.392186
A549_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128682
BRD-K79965790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5003
A549_Aminoglutethimide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183372
Crohn's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.199
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.23108
GSE124410_6_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PKNOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7433
PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-ensembl_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K13113551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38287
BRD-K07895476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18267
BRD-K20853228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30126
RXRA::VDR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4
CRCGN016_MCF10A.TP53.M_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15208
GSE202434,GSE202438_12_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE185519_6_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152432_1_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CB-16-SY72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.718457
GSE172295_1_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K61033092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14397
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.11284
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.32181
BRD-K32918816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55501
BRD-K29420358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07203
DA-17-XI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.352818
Organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE216043_11_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Agammaglobulinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.093
Brain - Frontal Cortex (BA9)	GTEx Tissue Gene Expression Profiles 2023	1.0	3.8766
GSE205070_2_v_9_mertk_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Severe congenital neutropenia 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.274
BRD-K51012353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42817
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.21736
TAK-901_NCI-H2347	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00341187
DIAPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04188
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.74769
wgd5	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.692
BRD-K68328788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.49657
GSE214823,GSE214824_0_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K76008396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75789
BRD-K64347765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55719
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.46802
D458	DepMap CRISPR Gene Dependency	1.0	3.78375
GSE196699_2_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K04365932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19723
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.771657
MERO25	DepMap CRISPR Gene Dependency	1.0	3.08966
BRD-K15259307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17696
GSE216043_10_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH358	DepMap CRISPR Gene Dependency	1.0	2.47379
GSE157036,GSE166411_3_v_1_halofuginone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.3383
GSE124410_6_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Wiskott-Aldrich syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.723661
Dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
X-linked agammaglobulinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.173
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K39571490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28381
GSE157894_1_v_3_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.51
AF-99-HA02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243495
EE-98-PF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292771
9212_TPRKB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.511348
CRCGN012_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47297
BRD-K20398543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71115
BRD-K10483446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33785
LNCAPCLONEFGC_PROSTATE	CCLE Cell Line Proteomics	1.0	4.78077
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE185519_6_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146840,GSE146842_0_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K29135120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.226
GSE205163,GSE205164_1_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EB-67-WB79_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234267
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.58222
BRD-K42789863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10184
Suppurative lymphadenitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.915
GSE139455_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Tertiary granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.742
GSE216273,GSE216292_0_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nail disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K67211407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31611
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.85866
PANC1_PANCREAS	CCLE Cell Line Proteomics	1.0	4.89743
BRD-K89354557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24084
Candidiasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.188
GSE142210_9_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03405
FOSL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0423
MCF7_Baricitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177296
BRD-K79407655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11557
BRD-K72255851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.018
BRD-K46562329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19974
BRD-K83013052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18588
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.715
GSE206779_1_v_3_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K56708236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91433
GSE202434,GSE202438_3_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.099
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K32037893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64524
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
BRD-K30937829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1044
Osteomyelitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.535
8467_ST20-MTHFS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.550697
BRD-K50710005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00147
AA-85-LB25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251256
GSE73562,GSE73563_1_v_2_preb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GCM2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8247
DF-00-BX35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269291
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.58621
Oxoglutarate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.627
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.62836
GSE175787_11_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K45400577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86475
A549_Hesperadin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013043
Herpangina	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.026
BRD-K71139459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00918
GSE166294_0_v_1_etv5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K30933750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48092
GSE119978,GSE180930_0_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHP212	DepMap CRISPR Gene Dependency	1.0	10.0311
GSE188570,GSE188571_3_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EF-99-HJ48_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202394
A549_Azacitidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131548
GSE154464_1_v_2_cdk6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
REL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55998
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.248
PMC5263239-mmc2.xls-SEM_wt_MLL-Gene_name_1614_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A73965025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.74323
GSE190322,GSE190324_3_v_4_rbm4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198380_0_v_1_phgdh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.669668
CRCGN015_MCF10A.TP53.M_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1563
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NME3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28489
ZNF28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84477
GSE165308_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126345_9_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162892_3_v_2_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE48812_4_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.513322
SKHEP1	DepMap CRISPR Gene Dependency	1.0	2.07634
GSE206729_5_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120370_4_v_1_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119978,GSE180930_0_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE146074_0_v_11_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223008_5_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.26164
DC-47-KV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30131
CRCGN013_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.59319
SMIM14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12702
NC-01-ET52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218846
BRD-K92607052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56482
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE215086_1_v_6_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_13_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.46185
BRD-K91876603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02433
BOLA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03853
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.21592
NCIH1755	DepMap CRISPR Gene Dependency	1.0	11.298
BRD-K71493640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38398
GSE208254_4_v_5_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166920_6_v_3_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
SMC1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79924
GSE242647_2_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.96335
BRD-K52157065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0556
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.00323
BRD-K69154646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01885
ATP5F1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02017
USP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33601
BRD-K81586131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06545
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Acitretin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.28
AB-71-CI37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254653
GSE211177,GSE211178_9_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Capecitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174489
BRD-K82967678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63606
GSE255680_2_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ACTL6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.08958
PMC3435504-msb201237-s2.xls-Supp_Table_4b-STAT1_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K10640729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07919
BRD-K43316594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38025
GSE183413_0_v_2_ash1l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Peripheral blood stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.561
BRD-K17062413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09084
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
SUPT6H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68747
Ibrutinib1	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
GSE205687_1_v_0_mta1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.16532
GSE188570,GSE188571_5_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BB-20-UU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.403967
ABITRAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00287
PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-gene_name_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.15586
DF-00-DK69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.349019
PMC9270251-mmc2.xlsx-4_Filtered_DEGs_Control_vs_KD_3-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Neuroacanthocytosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.089
BRD-K94647035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30089
GSE160246_0_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A26222320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69698
CAL33_UPPER_AERODIGESTIVE_TRACT	CCLE Cell Line Proteomics	1.0	3.75998
BRD-K73775927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07825
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
BRD-K30492965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06633
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
496100549_FWM_no dementia_TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.66659
Bloodstream form	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.633
BRD-K93488589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66153
GSE226355,GSE226357_1_v_0_ybx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223008_6_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GD-59-OG21_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225714
A549_PCI-34051_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130324
BRD-K40221630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12375
CRCGN008_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9827
BRD-K04325154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37085
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.5048
GSE181959_3_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147876,GSE147877_4_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
FD-59-TC81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.442026
EBV-B cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.41
HLF_LIVER	CCLE Cell Line Proteomics	1.0	2.01939
GSE118077_4_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CF-24-KQ98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270075
BRD-K43295075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02248
Membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.895
GSE201110_0_v_1_sirt4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K34254821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46929
8288_SOX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.533469
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.717585
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.12318
GSE157555,GSE157556_0_v_6_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.143
A549_UNC1999_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131662
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.08349
CRCGN009_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20644
GSE138938_1_v_4_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K94247332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10787
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.439
BD-38-QC39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219943
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.33014
PRDM16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63909
GSE130217_5_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Diarrhea	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.395
22RV1_PROSTATE	CCLE Cell Line Proteomics	1.0	6.95127
PMC9181267-mmc5.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K27919582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08963
c-Fms-IN-3	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
Genetic causes of porto sinusoidal vascular disease	WikiPathways Pathways 2024	1.0	null
Aril	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.967
BRD-K66580188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23735
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.9917
GSE226091,GSE226092_0_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Peripheral blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.186
Bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.299
Hepatic venoocclusive disease with immunodeficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
CRCGN017_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1352
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.687287
GSE60217_1_v_8_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ookinete	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.705
JB-14-TF61_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258491
BRD-K92239253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36611
BRD-K80443236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06237
GSE193402_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Combined immunodeficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.232
West Nile encephalitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
ZNF480	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01993
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_U87MG_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210101,GSE210114_0_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154081_1_v_0_sildenafil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.62586
GSE203158_0_v_13_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE82110,GSE82299_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.04545
BRD-K25185158	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53124
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228413_0_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE79572_0_v_1_pax8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146982_4_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A-61603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6213
BRD-K17061569	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37969
BRD-K93197397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14817
GSE124410_3_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.73055
RK-24466	DeepCoverMOA Drug Mechanisms of Action	1.0	0.39
BRD-K67638302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02544
BRD-K61144709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01853
respiratory burst after phagocytosis	GO Biological Process Annotations 2025	1.0	null
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.0451
MAP3K4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17555
BRD-K22584556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00082
OC-71-BZ81_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212505
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.317545
CB-31-UO16_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263901
GA-28-SS67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.46752
AB-80-CK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.436202
GSE228106_3_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE124410_2_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain - Anterior cingulate cortex (BA24)	GTEx Tissue Gene Expression Profiles 2023	1.0	4.52063
SNAPC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40577
TPMT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00347676
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.61576
CRCGN017_MCF10A.WT.HP_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24435
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.94461
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.93598
6855_PSMB6_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.552843
BRD-K35347834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.46499
CEP120	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63855
FA-88-II68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289455
FB-39-CW59_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246304
FF-28-ES17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208624
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.37
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.564816
Animal cap	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.905
6845_PSMA5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.609292
BRD-K58275986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48702
GB-73-QS80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224197
MCF7_Meprednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169
RPL27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02867
Df	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.516
GSE221327_1_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K02070226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28518
AC-30-XU83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.437092
RFXAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05902
BRD-K72519622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43513
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.768264
PMC8322331-41598_2021_94805_MOESM3_ESM.xlsx-b_STAT3_UP_assoc_transcripts-Gene_Name_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K09875820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64118
GSE208254_3_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-87-SF89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.623877
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.29798
KDM8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00462919
UB-40-KU41_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.339973
GSE71491_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BD-69-GX17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275098
glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.739
7476_RPL6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.559541
GSE211177,GSE211178_0_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BE-79-QU25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.548408
EC-01-PH79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235497
BRD-K27458941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80704
SW1463	DepMap CRISPR Gene Dependency	1.0	2.27424
GSE147210_3_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.74778
MRPL30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03445
BRD-K56916066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39454
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.88813
GSE48812_7_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149969
BRD-K27111500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49761
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.11013
SMARCE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23301
BRD-K38350115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48417
Schizont	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.682
A549_Aurora A Inhibitor I_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158409
SLC25A13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33241
GSE165122_0_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K96745500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9224
increased circulating sodium level	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K43086600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74673
MSH4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73552
BRD-K29460044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3593
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.5942
4908_MCOLN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.510288
GSE133683_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_ABT-737_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136197
7251_RFFL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.684397
MA-06-DJ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270104
BB-20-UU03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.355236
BRD-K23997756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07529
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.412555
PMC10534007-Table_3.xlsx-S8_unique_down_MSC_V_2-345_elements_included_exclusively_in_VMCUB1_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186223,GSE186224_6_v_3_hmces_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Exhausted CD8+ T cell_Liver_Human	CellMarker Gene-Cell Type Associations	1.0	null
MCF7_PD173074_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013893
GSE130081,GSE130082_4_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.14292
CRCGN009_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20407
GSE103068_0_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.3835
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.0
CRCGN013_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7008
GSE126621,GSE126920_1_v_3_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FA-36-VA24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.85798
LCN12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16372
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.67006
GSE186483_6_v_4_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KE-73-XV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.97235
Hemophagocytic lymphohistiocytosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.579
Plasma membrane proton-transporting ATP synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.687
isoetharine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19776
GSE105169,GSE105175_0_v_1_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE162892_3_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K64434200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75362
SUSA	DepMap CRISPR Gene Dependency	1.0	3.62932
BRD-K77504251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51003
BRD-K71561082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08226
GSE158834_2_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.57906
BRD-K47999752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03444
32D clone3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.977
A549_Carmofur_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155195
BRD-K06790927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43049
AD-43-XJ59_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229279
Acenaphthoquinone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
GSE63048_11_v_12_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.159
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.04164
GSE203158_0_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
tiotropium	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-6.84527
A549_Selisistat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143987
PDCD2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26586
NMB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00530008
PMC10928104-41419_2024_6576_MOESM4_ESM.xlsx-S14-E2F1_2_3_targets_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
Cerebellum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.59867
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Ivosidenib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156179
BRD-K27178862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71342
GSE180200,GSE180201_3_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K93335719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23122
Rhoptry	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.556
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.1054
BRD-K49707067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10844
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
7751_SEC61A1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.21837
Hyper IgE syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.193
PMC8322331-41598_2021_94805_MOESM3_ESM.xlsx-b_STAT3_UP_assoc_transcripts-Gene_ID_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K59221664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79077
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5640240-ppat.1006668.s013.xlsx-MAX_ChIP_shEP400-1-Unnamed_6_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221327_10_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K81804676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31014
GSE145323,GSE145324_1_v_4_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K73177528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7088
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160001,GSE160670_3_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Metencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K92008394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60802
DE-62-FI29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224906
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
TRIM66	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28116
GSE152432_1_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K51272331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27956
GSE228413_2_v_1_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH460	DepMap CRISPR Gene Dependency	1.0	2.30333
decreased circulating potassium level	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K33350866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40729
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE96544_1_v_0_mebendazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE230354_0_v_1_rheb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169155_5_v_4_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K48069820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61485
CRCGN011_HEPG2_24H:C16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0684
BRD-K62942008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43439
GSE48812_7_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE175787_5_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Immune system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
PMC6684323-NIHMS1532201-supplement-Table_S6.xlsx-LPS-Sup_Table_6C_Delta_PVE_among_PopDE_genes_LPS_PopDE_FDR_0_2_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K22193148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1697
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.759726
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.383287
MEOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80627
GSE103068_0_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE60217_1_v_7_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170952
Cell periphery	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.895
BRD-K76329122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03037
GSE152379_0_v_4_bach2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.743239
BRD-A08778300	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05427
BRD-K24204732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73748
BRD-K51411441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7295
GSE175787_5_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K89179622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33063
A549_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156822
PMC11991920-41556_2025_1639_MOESM3_ESM.xlsx-DEGs_MI_vs_Ctrl_HSCs_padj0_1-gene_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
8653_TAF12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.670079
GSE139455_2_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119694_1_v_0_lifr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.3245
CRCGN016_MCF10A.WT.HP_24H:O09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8866
PREB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03808
Sto	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.796
GSE112761,GSE112767_2_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GC-69-JF03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237374
Aphthous stomatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.329
CA-75-HA22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.04018
GSE71529,GSE71558_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE172295_4_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K63270352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59099
3054_FECH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.500936
OS9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17617
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.86385
A549_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015941
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.16546
BRD-K24659381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72181
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DC-93-NP78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.564201
GSE228413_4_v_1_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Stomatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.271
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.98811
Chromosome 17q12 deletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.10684
PMC9859043-elife-78421-supp9.xlsx-LHX8_P-Gene_symbol_LHX8	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Nintedanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163307
MCF7_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147584
GSE206226_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Lenalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163021
K562_KW-2449_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171988
SOHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2833
A549_GSK-LSD1 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191142
BRD-K95422706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42991
BRD-K37213205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11802
BRD-K15160697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37357
BRD-K11677408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06926
GSE188884,GSE189078_2_v_3_ebf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CB-44-RT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264268
Tuberculosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
PLB-985 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.813
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.81494
interleukin-23 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.586
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.86675
A549_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124222
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE245407,GSE245412_0_v_1_smurf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.681408
AD-28-GJ71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221041
RBM8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4278
BRD-A94698726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40357
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.9797
HE-80-BQ08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.342507
7478_RPL7L1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.530005
GSE171572_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null