association	dataset	threshold value	standardized value
GTEX-U8XE-0426-SM-3DB91	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
Cimetidine	CTD Gene-Chemical Interactions	1.0	null
GTEX-O5YV-0226-SM-48TBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04169
USP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51264
ZSWIM8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46811
Weight Loss	CTD Gene-Disease Associations	1.0	1.67224
H3K4me1_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC6932815-ppat.1007634.s011.xlsx-ST1_DGE_ELF1_lfc2_fdr05_interse-external_gene_name_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
HYOU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76707
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
Primary somatosensory area, upper limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18763
GTEX-XMD1-0011-R6A-SM-4AT5K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875113
nialamide-3790	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WHSE-0926-SM-3NMBS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.998554
abnormality of the teeth	GWASdb SNP-Phenotype Associations	1.0	0.177625
regulation of heart contraction	GO Biological Process Annotations 2015	1.0	null
integral component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.323825
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1HY-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242199_6_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K25447152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0322
Water	HMDB Metabolites of Enzymes	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A59X-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
496100380_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.13887
CCNA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51545
H3K27ac_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09724
epitiostanol-4788	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-U3ZN-1226-SM-4DXUD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.898198
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6935-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5404269__F8	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K07624584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11418
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1648	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.967535
PMC10773028-40364_2023_552_MOESM1_ESM.xlsx-Variants_sheet-TFT_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PWO3-0011-R6A-SM-2I5F3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850403
CRCGN014_HEPG2_24H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.95345
inhibitors	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K44139185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08686
periventricular stratum of PcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31051
GTEX-S32W-0626-SM-2XCBG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927245
cardiacspecific	GeneRIF Biological Term Annotations	1.0	null
activities	GeneRIF Biological Term Annotations	1.0	null
GTEX-RTLS-0226-SM-2TF5E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
BRD-K36493118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40033
KYSE-150	GDSC Cell Line Gene Expression Profiles	-1.0	-1.56762
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.86
KCNK12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.003455
COMPOUND 4 [PMID: 16495056]	DGIdb Drug Targets 2026	1.0	8.822
BRD-K92950328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80759
hsa-miR-548m	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Prostate adenocarcinoma_PRAD_TCGA-YL-A8S9-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.02118
Posterior parietal association areas, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53408
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
type 2 diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.497877
conjunction	GeneRIF Biological Term Annotations	1.0	null
GSE207728,GSE207808_2_v_1_c646_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF391	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29373
BRD-K70183558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05149
milrinone-7210	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
skeletal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061969
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.931017
EMC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63943
entorhinal cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08333
16166618-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
Telencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4887-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
olfactory epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.304279
CRCGN017_MCF10A.TP53.M_24H:P16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01276
GTEX-Q734-0326-SM-48U15	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962187
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9RL-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
protein1	GeneRIF Biological Term Annotations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-3771-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.25
H3K9ac_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
rostral division of VL	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18575
Sarcoma_SARC_TCGA-PC-A5DO-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
diseases	GeneRIF Biological Term Annotations	1.0	null
determining	GeneRIF Biological Term Annotations	1.0	null
specificity	GeneRIF Biological Term Annotations	1.0	null
vertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.21846
hypertrophic	GeneRIF Biological Term Annotations	1.0	null
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOPX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8549
PCDHB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55891
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
GTEX-XV7Q-0726-SM-4BRV6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03572
GSE135030_11_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PRR14L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00431511
Drug-Related Side Effects and Adverse Reactions	CTD Gene-Disease Associations	1.0	1.32339
Metabolism of lipids and lipoproteins	Reactome Pathways 2014	1.0	null
contains	GeneRIF Biological Term Annotations	1.0	null
SMC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69159
GSE129811_5_v_0_niacin_human	RummaGEO Drug Perturbation Signatures	1.0	null
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
FAM86C2P	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2546
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A6QX-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pathogenesis	GeneRIF Biological Term Annotations	1.0	null
genotype	GeneRIF Biological Term Annotations	1.0	null
GDE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.78109
Cardiovascular Diseases	HuGE Navigator Gene-Phenotype Associations	1.0	null
Abdominal adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.212
hydrolysis	GeneRIF Biological Term Annotations	1.0	null
PPM1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26937
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.74506
increases	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_iPS-15b	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ventricular	GeneRIF Biological Term Annotations	1.0	null
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.859096
mitochondrion	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.2719
BRD-K43025624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08991
GSE96777,GSE96778_3_v_2_zbtb4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PIP5K1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00490295
496100537_FWM_no dementia_TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.13025
ALAD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00582471
SW780	CCLE Cell Line Gene Expression Profiles	1.0	1.64618
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Microvessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.323
olfactory bulb, principal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.49227
Disease Progression	HuGE Navigator Gene-Phenotype Associations	1.0	null
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TDOTT	DepMap CRISPR Gene Dependency	1.0	2.71219
intrinsic component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.245685
arachidonic acid 11,12-epoxygenase activity	GO Molecular Function Annotations 2023	1.0	null
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.840865
GTEX-S33H-1626-SM-4AD68	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11013
highly	GeneRIF Biological Term Annotations	1.0	null
Human aortic endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.753
NUDT21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7166
trifluoperazine-6984	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cerebral hemisphere	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5987-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7708794-mmc2.xlsx-DGE_table_Imm-high_vs_Imm-low-TFT_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1218
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K64890080_BI-2536_PC3_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAX_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Plastid thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.539
endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.35722
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.297
restriction	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner CP in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.881464
fatty acid derivative metabolic process	GO Biological Process Annotations 2015	1.0	null
membrane part	GO Cellular Component Annotations 2015	1.0	null
BRD-U07805514_saracatinib_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.5012
TBC1D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49683
Microbody	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.935
IFI27L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53452
Oxidation by cytochrome P450	WikiPathways Pathways 2024	1.0	null
MALL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26988
EN	DepMap CRISPR Gene Dependency	1.0	2.31003
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K33200274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04757
TDRD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38642
medial geniculate complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.92175
china	GeneRIF Biological Term Annotations	1.0	null
compared	GeneRIF Biological Term Annotations	1.0	null
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.57
FOXA1	JASPAR Predicted Transcription Factor Targets	1.0	null
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17539
BRD-K16541732_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pulmonary artery smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.387027
CAMKMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7891
BRD-K45569026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12704
GSE191110_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Dlx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	13.507
paraventricular nucleus, peduncular or principal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6701
14555994-Table1	GeneSigDB Published Gene Signatures	1.0	null
ZNF513	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00580333
GSE245778_1_v_0_runx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K78747341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53943
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
inner CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.48657
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE186287_1_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
mephenesin-2304	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cerebellar cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.841805
19061838-TableS3	GeneSigDB Published Gene Signatures	1.0	null
GTEX-U8XE-1826-SM-4E3HV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832981
Sarcoma_SARC_TCGA-JV-A5VF-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.332711
BxPC-3	GDSC Cell Line Gene Expression Profiles	1.0	2.12076
Kidney failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.706
Metapathway biotransformation Phase I and II	WikiPathways Pathways 2024	1.0	null
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_12_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8841
EFEMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81305
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Formic acid	HMDB Metabolites of Enzymes	1.0	null
RFK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23174
rottlerin-914	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZPBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00609481
GTEX-U412-0226-SM-3NMC8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922519
BRD-K67319345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09581
BE2M17	DepMap CRISPR Gene Dependency	1.0	2.25943
coronary artery disease	GAD Gene-Disease Associations	1.0	null
GTEX-TKQ1-0226-SM-33HB5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
ARPC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00389652
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-6742-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE116492,GSE116495_3_v_2_stag2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PLZ5-1826-SM-3NB22	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.831224
PMC12559107-12035_2025_5221_MOESM1_ESM.xlsx-Supplment_Tab_3-Supplement_Tab_3_The_result_of_MR_analysis_for_SCZ_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K66214118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58833
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QF-01A-21R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Vascular endothelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.068
Perturb_9446_KO_STK25_SRP356933	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.9594
spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.624254
Perturb_11354_KD_METTL3_SRP292229	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.99458
Lung squamous cell carcinoma_LUSC_TCGA-60-2713-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3357-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9437808-mmc3.xlsx-IPA_Upstream_regulators-IPA_Upstream_regulator_analysis_Up_regulated_genes_following_LPS_treatment_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
SNU16	CCLE Cell Line Gene Expression Profiles	1.0	1.73191
GSE187006_0_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_47_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
deep layers of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.977422
Henles loop	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.84
layer 3 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59879
tools	GeneRIF Biological Term Annotations	1.0	null
rs338583	GeneRIF Biological Term Annotations	1.0	null
hep-g2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.420385
SUP-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K54233340_Dorsomorphin dihydrochloride_RKO_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.841
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostatic Neoplasms	CTD Gene-Disease Associations	1.0	1.01474
extrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.561392
cardiovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.64206
CALU	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00506608
CRCGN013_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.26687
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CCDC88A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06845
GTEX-O5YW-0426-SM-3MJHJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
large	GeneRIF Biological Term Annotations	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A411-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X3Y1-0226-SM-3P5Z5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849442
AUTS2-25519132-293T-REX-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K39592958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51228
lm13	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.524
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24703
BRD-K38431962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95899
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.05413
DPY19L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22615
GSE182179_0_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
6-bromoindirubin-3'-oxime-7101	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K32577562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60505
GSE158834_10_v_6_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FGB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00670787
Tranylcypromine	CTD Gene-Chemical Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IB-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04416
OVCAR433	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11216
BRD-K19320442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20478
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.424
LM6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.532
tanespimycin-6943	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NFKBIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67306
longer	GeneRIF Biological Term Annotations	1.0	null
GTEX-UPK5-0326-SM-3GAF3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70725
GTEX-RNOR-0826-SM-2TF5C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03435
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBPJ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6557
BBLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.85485
RALB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49239
abnormality of carbohydrate metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.159057
RFX7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0702
clearance	GeneRIF Biological Term Annotations	1.0	null
BRD-K63024248	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21926
PYCR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65923
Inferior colliculus, dorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09053
BRD-K11414036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07456
Cardiomyopathies	CTD Gene-Disease Associations	1.0	1.16104
alleles	GeneRIF Biological Term Annotations	1.0	null
18318837-Table1	GeneSigDB Published Gene Signatures	1.0	null
Gustatory areas, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17679
Lateral septal nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17263
Arteriosclerotic cardiovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.81
BRD-K32205799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12671
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.421765
smallintestine_4b	HPA Tissue Sample Gene Expression Profiles	1.0	0.92929
posteroventral (inferior) parietal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.990837
Rarg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	95.3643
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.2642
Pre-Eclampsia	DisGeNET Gene-Phenotype Associations	1.0	null
9(10)-EpOME	MW Enzyme Metabolite Associations	1.0	null
BRD-K54505405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27407
Adult_Liver	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.52507
RNASE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93825
SGHPL-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.302
GTEX-OIZG-1126-SM-2HMIU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10203
BRD-K62213484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.56918
Perturb_2494_Mut_ESR1_SRP254635	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
MICALL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60822
heart	GeneRIF Biological Term Annotations	1.0	null
thioridazine-1010	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
vascular endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.09827
PMC4367834-12864_2014_6889_MOESM9_ESM.xlsx-Network_Parkinson_s_Disease-TBP_TBP	Rummagene Transcription Factor Associations 2026	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.52521
orbital frontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.54825
BRD-K76336129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47804
Renal epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.111
CACO2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50908
monensin-4726	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A49I-01A-12R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.267
SLCO4A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00612329
PAX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86071
erk12	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC6366065-13075_2019_1816_MOESM1_ESM.xlsx-DOD_Skin_imputed_log2_median_ce-Name_PIN1	Rummagene Transcription Factor Associations 2026	1.0	null
cjun	GeneRIF Biological Term Annotations	1.0	null
Crohn Disease	DisGeNET Gene-Disease Associations	1.0	null
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.824194
myocardium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.536625
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GATA1-30185409-K562-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.834213
Anemia	CTD Gene-Disease Associations	1.0	1.28395
18722011-SuppTable2p	GeneSigDB Published Gene Signatures	1.0	null
coronary artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.12571
LS-513	GDSC Cell Line Gene Expression Profiles	1.0	2.57255
DLD-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
AN3-CA	GDSC Cell Line Gene Expression Profiles	-1.0	-1.48288
Visual areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05887
BRD-K24502602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2264
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K46599443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76758
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE158182_4_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.834111
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.719
SNUC4	CCLE Cell Line Gene Expression Profiles	1.0	1.59687
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K63410075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.6027
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
small intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.442962
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
p388/dx	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.874
Artery - Coronary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.716533
clofazimine-4682	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
J82	GDSC Cell Line Gene Expression Profiles	-1.0	-2.27405
H3K4me1_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:I06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20031
CRCGN015_HEPG2_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.98275
BRD-K29264158	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09797
PARP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0036047
corpus callosum	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K69744558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55133
PMC7497168-FSB2-34-10640-s004.xlsx-Supplemental_Table_1_SNPs_MAF_0-Gene_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WFJO-1026-SM-3GIKL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.912008
POLR2A	ENCODE Transcription Factor Targets	1.0	null
GSE111061_1_v_0_tofacitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OHPK-2426-SM-3MJGH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPL16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6069
CAOV3	CCLE Cell Line Gene CNV Profiles	1.0	1.58188
syndrome	GeneRIF Biological Term Annotations	1.0	null
DHX38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31003
primary motor cortex (area M1, area 4)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25686
Anemia, Hemolytic	CTD Gene-Disease Associations	1.0	1.0241
DLG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.35561
BRD-K81447429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.42579
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.262
Bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.136
Pulmonary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.563
lateral hypothalamic area, anterior region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.933878
Paraventricular hypothalamic nucleus, descending division, lateral parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00457
LTBR_INHIBITION - 27 Day_GDS2005_731_mouse_Lymph nodes  (MG-430B)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Citalopram	HMDB Metabolites of Enzymes	1.0	null
normalvariation	GAD High Level Gene-Disease Associations	1.0	0.293278
oxygen binding	GO Molecular Function Annotations 2015	1.0	null
Artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.0
Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)	Reactome Pathways 2014	1.0	null
Sarcoma_SARC_TCGA-IF-A4AK-01A-21R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
metal ion binding	GO Molecular Function Annotations 2015	1.0	null
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE182179_0_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC1557825__F4	PFOCR Pathway Figure Associations 2023	1.0	null
without	GeneRIF Biological Term Annotations	1.0	null
medial group of nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08638
GTEX-X8HC-1626-SM-46MWE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38822
BRD-K43387144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34921
BT549	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.70638
fat_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.13282
globose nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.84651
specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.068174
ACSS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00544064
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.98248
superficial stratum of PCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10343
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27339
HNF4G	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6595
DLD1	CCLE Cell Line Gene Expression Profiles	1.0	1.77171
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
EB-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FBRS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86966
GSE135514_8_v_7_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
proliferation	GeneRIF Biological Term Annotations	1.0	null
BRD-K13515483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00731
NAB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.961
immunoreactive	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE182179_0_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cyp2c83	GeneRIF Biological Term Annotations	1.0	null
GI1	CCLE Cell Line Gene CNV Profiles	1.0	2.60345
Allergic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
11,12,15-THETA	HMDB Metabolites of Enzymes	1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-5654-11A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K62718031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07077
Urine	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.819
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Brain Lower Grade Glioma_LGG_TCGA-HT-7680-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE194396,GSE194429_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Thrombosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.686
A-CA-04-2009(H1N1)_12Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.85008
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.976
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.921822
colon	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.959757
SOX7_OE_GDS3300_123_human_HESC (CA1 and CA2)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-U3ZN-2626-SM-3DB7T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981094
BRD-K72439355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96116
anterior group of nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.19168
BRD-K87995704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17406
Perturb_8654_KO_ESRRA/ESRRG_SRP304242	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Edinger-Westphal nucleus (accessory oculomotor nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05227
Liver Diseases	CTD Gene-Disease Associations	1.0	1.38946
fenbendazole	GeneRIF Biological Term Annotations	1.0	null
BRD-K64811593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3518
PMC7863452-12920_2021_883_MOESM5_ESM.xls-SRG_13_GE2-HCC_vs_17NT-GENENAME_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K93755725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24119
Lipid and atherosclerosis	KEGG Pathways 2026	1.0	null
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.926315
chronic pulmonary heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.321545
BRD-K88087295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.2402
Primary somatosensory area, upper limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24498
skin	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MAX_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.21917
BRD-K07667606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.58284
BRD-K64836560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63246
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.52413
motor nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.80599
GSE214382,GSE214383_0_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K87909389_alvocidib_HA1E_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
prevention	GeneRIF Biological Term Annotations	1.0	null
posteroventral (inferior) parietal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.890108
CCK81	CCLE Cell Line Gene Expression Profiles	1.0	1.54228
NANOG-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
15656903-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
hsa-let-7b-5p	MiRTarBase microRNA Targets	1.0	null
Left_Ventricle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.19309
BRD-K77908580_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
VPS25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90708
BRD-K75983763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03001
HNRNPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29038
metabolism	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33915
Primary somatosensory area, barrel field, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05593
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XOT4-1126-SM-4B66E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28855
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.990837
VWCE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69609
GSE214382,GSE214383_6_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4903-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAD21	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0105841
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.053
DCTN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77771
Taenia tecta, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45224
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K93788137_PF-431396_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Coronary Heart Disease	DisGeNET Gene-Disease Associations	1.0	null
TUBA1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40287
Arteriosclerosis	DisGeNET Gene-Disease Associations	1.0	null
Amino acid metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.026
cyproheptadine-1521	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-4653-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
TARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8726
susceptibility	GeneRIF Biological Term Annotations	1.0	null
11H-14,15-EETA	HMDB Metabolites of Enzymes	1.0	null
NCIH2882	DepMap CRISPR Gene Dependency	1.0	3.49061
HCC2218	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.697472
H2AC21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00805
oxidoreductase activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K49945136_GR 113808_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hepatoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.344818
inner SZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01553
GTEX-RVPU-2326-SM-2TF6R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
BRD-K06284373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15482
periventricular stratum of IC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17019
GABBR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00534902
Brain Lower Grade Glioma_LGG_TCGA-P5-A5EV-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17516
GSE48812_9_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10274745-media-4.xlsx-S3A-Table_S3_Reanalysis_of_publicly_available_data_to_identify_AR_and_ER_direct_target_genes_related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K65265098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05627
H3K9me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.983112
H3K9me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.13247
sf-9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.8601
H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
DMAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49407
more	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-3921	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
ZNF836	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35507
BRD-A59985574_T542500_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BV-173	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K92825272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4624
ZFYVE19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69971
NR2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7818
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Nucleus of the brachium of the inferior colliculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07264
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7183-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Warfarin resistance	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
NCIH1876	CCLE Cell Line Gene CNV Profiles	1.0	1.44316
EVSAT	CCLE Cell Line Gene Expression Profiles	1.0	1.38533
MFE-319	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Brain - Hypothalamus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.669047
Pruritus	CTD Gene-Disease Associations	1.0	1.14575
GTEX-QEG5-0626-SM-2S1PP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923761
NOG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7732
mesenteric artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.6182
SRSF9_02_13	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.70044
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Spinalcord	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.87998
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21883
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.176
BRD-K70712801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91793
aortic	GeneRIF Biological Term Annotations	1.0	null
CAL78	DepMap CRISPR Gene Dependency	1.0	2.1498
BRD-K64823749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10036
CRCGN017_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1775
Prostate adenocarcinoma_PRAD_TCGA-J4-A83J-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.333763
GSE184892_4_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
due	GeneRIF Biological Term Annotations	1.0	null
GIGYF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41535
thioproperazine-5791	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.047
GTEX-QEG4-1226-SM-2S1P6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
Pericardial fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.556
15674343-Table2	GeneSigDB Published Gene Signatures	1.0	null
GAB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2996
MTAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00517313
MPDU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16912
GTEX-XQ3S-0526-SM-4BOQA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72566
A549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.843742
digestive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Hep-G2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.72
eicosanoid metabolism	Biocarta Pathways	1.0	null
HT55	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32355
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	Reactome Pathways 2014	1.0	null
496100313_HIP_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.72189
BRD-K79090631_CGP-60474_HA1E_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCT116	DepMap CRISPR Gene Dependency	1.0	3.21617
CILP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.69257
posteroventral (inferior) parietal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.37332
Posterior parietal association areas, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45346
VMA21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84069
NCI-H2141	COSMIC Cell Line Gene Mutation Profiles	1.0	null
UHRF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00404512
Brain Lower Grade Glioma_LGG_TCGA-DB-5275-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
products	GeneRIF Biological Term Annotations	1.0	null
odemethylation	GeneRIF Biological Term Annotations	1.0	null
TMEM160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1205
Dhori Virus_48Hour_20090954_GSE17400	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.3395
intermediate stratum of PHyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48248
activator	GeneRIF Biological Term Annotations	1.0	null
GTEX-R55E-1026-SM-2TC5S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04566
BRD-K67278762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24211
alpha-naphthoflavone	CTD Gene-Chemical Interactions	1.0	null
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K62852603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77963
layer V of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.957304
ZFAND4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78681
ENSG00000230707	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36834
Lung adenocarcinoma_LUAD_TCGA-86-A456-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6883
loss	GeneRIF Biological Term Annotations	1.0	null
H3K9me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-6738-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Body Weight	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K79090631_CGP-60474_MDAMB231_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A5F1-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE160817_7_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4981-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer 2 of LPrP cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20518
encoding	GeneRIF Biological Term Annotations	1.0	null
GR-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.40458
GTEX-S4UY-1226-SM-4AD51	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.931113
BRD-K10580455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24631
Cytosolic aryl hydrocarbon receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.502
HOXA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57874
GABPA	ENCODE Transcription Factor Targets	1.0	null
CHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19936
overexpressing	GeneRIF Biological Term Annotations	1.0	null
GTEX-WL46-0726-SM-3LK5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03455
GSE155031_5_v_3_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
meninx	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.118724
CUX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68696
Hypertension	HuGE Navigator Gene-Phenotype Associations	1.0	null
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
WDR75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22282
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.894868
Fibrosis	CTD Gene-Disease Associations	1.0	1.62803
CCNB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00393835
moderately	GeneRIF Biological Term Annotations	1.0	null
H3K4me1_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
when	GeneRIF Biological Term Annotations	1.0	null
epoxygenase p450 pathway	GO Biological Process Annotations 2015	1.0	null
Foxo1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.6512
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965934
BRD-K79090631_CGP-60474_HA1E_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SARC9371	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K40630587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06522
chr1_59922064_C_G_b38	GTEx eQTL 2025	1.0	1.50104
BRD-K99545815_PF-562271_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Macular degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
Arachidonate epoxygenase epoxide hydrolase	WikiPathways Pathways 2024	1.0	null
paraventricular nucleus, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.92263
neoplastic	GeneRIF Biological Term Annotations	1.0	null
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S1-Table_S1_Instrumental_variables_used_in_MR_analysis_of_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80V-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K91354770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57913
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.855815
HSF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3985
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K28619632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04969
MMP20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00625991
ATM_Deficiency_GDS1544_769_mouse_Lymph nodes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SLC16A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.93739
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7887-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K33997327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08663
GTEX-U8XE-0926-SM-3DB8V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04459
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7X2-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K69453266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.45735
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.70532
Lung adenocarcinoma_LUAD_TCGA-05-5715-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K31992830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12508
SLC10A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50877
SPDYE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15425
SLC1A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9011
MDM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12602
GTEX-QEL4-0926-SM-3GAD1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10616
KDELR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4807
GTEX-WI4N-0726-SM-3TW93	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06761
GTEX-TSE9-0226-SM-3DB84	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03216
GTEX-V955-2626-SM-3NM9F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13339
GSE48812_9_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
estradiol-6968	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CA3 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.40288
HCC1588	CCLE Cell Line Gene Expression Profiles	1.0	2.83466
homosalate-3797	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Attention deficit hyperactivity disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.603
communication disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.162707
Primary visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08434
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.65976
GTEX-NFK9-1326-SM-3LK5I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.837844
POLR2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14782
troglitazone	CTD Gene-Chemical Interactions	1.0	null
BRD-A13122391_16-HYDROXYTRIPTOLIDE_VCAP_6.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE158834_10_v_8_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YM-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K75076471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06455
small molecule metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K51454923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03904
GTEX-SIU8-0526-SM-2XCDP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833744
intronic	GeneRIF Biological Term Annotations	1.0	null
BRD-K53241408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09133
periventricular stratum of m2AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.09458
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PPP2R2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20969
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
decreased litter size	MGI Mouse Phenotype Associations 2023	1.0	null
E2F4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11386
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K44121468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02148
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6HZ-11A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.400527
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4759-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8047-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K95500312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95421
GSE115395_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046129
KDM2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00636315
SPN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0071628
TGFBR2_knockout_295_GSE45968	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.53788
Cells - Cultured fibroblasts	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.696919
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11845
trifluoperazine-1649	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
layer 3 of LPrP cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25844
c-MYC_KD_GDS2526_110_human_BT-474 BREAST CANCER cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Small luteal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.715
GTEX-X4XX-0011-R2A-SM-3P623	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0678
H3K9ac_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_9102_KD_KDM3A_SRP202026	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.3324
SMG6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50819
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5463-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06652
ZDHHC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48274
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.586
GTEX-SIU7-0426-SM-2XCDX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935689
NDUFAF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7873
Anteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.94474
5,6-Epoxy-8,11,14-eicosatrienoic acid	HMDB Metabolites of Enzymes	1.0	null
HEY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.906599
Sarcoma_SARC_TCGA-DX-A2IZ-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal renal transport	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K03254663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31514
BRD-K87909389_alvocidib_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UBE2T	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20142
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K50836978_Purvalanol A_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7103-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
8MGBA	CCLE Cell Line Gene CNV Profiles	1.0	1.50503
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-6507-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K75688032	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46146
ATOSB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20235
GTEX-XBED-1426-SM-4AT4G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09225
PGM2L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00663042
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_24hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC6436215-13073_2019_626_MOESM2_ESM.xlsx-PCM-RXRA_RXRA	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05311
reaction	GeneRIF Biological Term Annotations	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-CTCFL_CTCFL	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WY7C-2726-SM-3NB3P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
attenuates	GeneRIF Biological Term Annotations	1.0	null
ischemic	GeneRIF Biological Term Annotations	1.0	null
BRD-A40431293_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Myocardium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.719
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NPJ8-0426-SM-2HMK6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961216
GSE147366_3_v_0_med13_human	RummaGEO Gene Perturbation Signatures	1.0	null
Sepsis	DisGeNET Gene-Disease Associations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-71-6725-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE111247_0_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Anterior hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47965
uterus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057349
BRD-K50190949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44729
Pulmonary fibrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.085
GTEX-R55C-1626-SM-48FEG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835015
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-PN-A8MA-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02614
PMC11993713-41598_2025_96655_MOESM1_ESM.xlsx-S10-Table_S10_MR_results_of_the_discovery_blood_cis-eQTLs_and_Sepsis_outcomes_in_IVW_or_Wald_ratio_methods_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
IRS2_KO_GDS1219_304_mouse_brown preadipocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Ptf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	70.9168
Occupational Diseases	HuGE Navigator Gene-Phenotype Associations	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58295
PMC4782046-supp_30.5.508_TableS2.xlsx-TAL1_UTX-co-bound_genes-Unnamed_4_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
Adrenal Gland	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.659756
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
relative	GeneRIF Biological Term Annotations	1.0	null
GSE158834_11_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.43496
BRD-K89820077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43959
KCNA6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00535921
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Tryptophan metabolism(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
COLO678	CCLE Cell Line Gene Expression Profiles	1.0	1.78011
Cardiovascular Diseases	CTD Gene-Disease Associations	1.0	1.19999
pharmacogenomic	GAD High Level Gene-Disease Associations	1.0	0.295739
BRD-K07526417	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23071
NDUFA11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18122
PRMT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1056
lipid metabolic process	GO Biological Process Annotations 2015	1.0	null
KLHL24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40915
layer 1 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70463
GSE261563_2_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160817_2_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
h9c2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.745864
Parkin_OE_GDS4476_55_human_U87MG	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE168401_2_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.858453
JIMT-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.12225
Gustatory areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12695
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K76984291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.60404
mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065515
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_3_AP1_Up_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
B3GNT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35292
Somatomotor areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05201
H-89-6873	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K80950551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16676
HL-60	COSMIC Cell Line Gene Mutation Profiles	1.0	null
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04234
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
GTEX-PWN1-2026-SM-48TD9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0133
GSE164505,GSE164506_3_v_2_indisulam_human	RummaGEO Drug Perturbation Signatures	1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
Defective CYP1B1 causes Glaucoma	Reactome Pathways 2014	1.0	null
TMEM267	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38434
USF1	ENCODE Transcription Factor Targets	1.0	null
NDUFS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00347191
BRD-K22720379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16086
BRD-K68073004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13279
HT-1197	GDSC Cell Line Gene Expression Profiles	1.0	2.11063
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.844368
Foxl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.9696
LIPE_KO_GDS1318_501_mouse_muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
microsomal	GeneRIF Biological Term Annotations	1.0	null
Urinary bladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.068
MDAMB175VII	CCLE Cell Line Gene CNV Profiles	-1.0	-1.65604
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4646-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Lateral visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00638
endoplasmic reticulum part	GO Cellular Component Annotations 2015	1.0	null
BRD-K45642123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64928
RMG-I	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Cell Transformation, Neoplastic	CTD Gene-Disease Associations	1.0	1.09646
tremorine-5799	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC6097700-pgen.1007515.s008.xlsx-S2_Table-S2_Table_SATB2_Cort_gene-set_list_SATB2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
an3ca	HPA Cell Line Gene Expression Profiles	-1.0	-1.05471
biotransformation	GeneRIF Biological Term Annotations	1.0	null
Sarcoma_SARC_TCGA-HB-A5W3-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WEY5-0726-SM-4LMID	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03178
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Aortic Aneurysm	DisGeNET Gene-Disease Associations	1.0	null
NDUFA7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00396873
Trophoblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.692
Mesenteric artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.302
GTEX-UPIC-0926-SM-4IHLV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25738
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.398
C3orf18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45239
arachidonic acid monooxygenase activity	GO Molecular Function Annotations 2015	1.0	null
parenchyma	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.00719
GTEX-POMQ-0326-SM-2I5FO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63538
GSE139455_2_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210101,GSE210114_4_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SPCS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7594
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)	Reactome Pathways 2014	1.0	null
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.90367
while	GeneRIF Biological Term Annotations	1.0	null
eet	GeneRIF Biological Term Annotations	1.0	null
KLF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08605
cardiac muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.429165
Brain infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
Sleep Apnea	DisGeNET Gene-Disease Associations	1.0	null
CBFA2T2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22251
felodipine-337	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.739
CFTR_Deficiency_GDS1843_192_mouse_Lungs - Animals examined at 6 weeks of age	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K4me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hematologic	GeneRIF Biological Term Annotations	1.0	null
Skin - Sun Exposed (Lower leg)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.62311
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-1226-SM-3NMA5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954589
PMC11961801-12672_2025_2262_MOESM2_ESM.xlsx-Sheet_1-WGCNA_AND_DEGs_NOT_CSGs_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
Liver Cirrhosis, Experimental	CTD Gene-Disease Associations	1.0	1.07482
SLC16A8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16747
significant	GeneRIF Biological Term Annotations	1.0	null
modulation	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KLHL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53002
dorsal preisthmic part of periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.09458
GSE261563_7_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
Colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
GTEX-R53T-1626-SM-3GAEW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02722
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Linoleic acid	HMDB Metabolites of Enzymes	1.0	null
H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
maprotiline-6676	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.995
Fever	CTD Gene-Disease Associations	1.0	1.34955
GTEX-QEG5-0926-SM-2TC64	GTEx Tissue Sample Gene Expression Profiles	1.0	0.971089
DDX52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26195
BRD-K55187425_ON-01910_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5581-01A-02R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
favorable	GeneRIF Biological Term Annotations	1.0	null
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
H3K79me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
liver	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
C2BBE1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.73615
albendazole	GeneRIF Biological Term Annotations	1.0	null
globus pallidus, external segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14961
H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
proteasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.267139
abnormality of dental structure	GWASdb SNP-Phenotype Associations	1.0	0.375166
BRD-K74039237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49744
diabetic retinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.13811
Liver hepatocellular carcinoma_LIHC_TCGA-K7-A5RF-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TMEM258	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29118
U2904	DepMap CRISPR Gene Dependency	1.0	4.55147
H3K9me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WI4N-1126-SM-3LK7Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hydrochlorothiazide-1487	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15815
nuclear	GeneRIF Biological Term Annotations	1.0	null
unrecognized	GeneRIF Biological Term Annotations	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
15(S)-HPETE	HMDB Metabolites of Enzymes	1.0	null
IFI6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00489208
nucleus of the stria terminalis, medial division, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1156
H2AC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47215
CMK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K54861624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12383
CL40	CCLE Cell Line Gene Expression Profiles	1.0	1.78314
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4863-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cyp2c19	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-502-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
aminophylline-3036	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pathways	GeneRIF Biological Term Annotations	1.0	null
nterminal	GeneRIF Biological Term Annotations	1.0	null
GSE202434,GSE202438_12_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061941
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
type 2 diabetes	GAD Gene-Disease Associations	1.0	null
H3K4me2_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RB_Deficiency_GDS2757_644_mouse_Embryonic livers (day 12.5)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NFYC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22722
well	GeneRIF Biological Term Annotations	1.0	null
medial group of nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15071
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.256925
Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)	Reactome Pathways 2014	1.0	null
H3K4me1_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K78288885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.064
Secondary hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
globus pallidus, internal segment, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.1583
Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)	Reactome Pathways 2014	1.0	null
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.882041
PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Unnamed_12_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
METTL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37641
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
endoplasmic reticulum membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Ovarian steroidogenesis	KEGG Pathways 2026	1.0	null
ARFGAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1525
Bladder disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.08
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
m1AD (DM) part of periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78785
Transient cerebral ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.145
periventricular stratum of PPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6701
GTEX-XPVG-0726-SM-4B658	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31693
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_Jurkat_LPS_vs_DC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.51192
residues	GeneRIF Biological Term Annotations	1.0	null
NR3C1	JASPAR Predicted Transcription Factor Targets	1.0	null
Testis	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.702597
ZNF132	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22328
GTEX-OXRK-1726-SM-3NB16	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941356
Piriform area, polymorph layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01011
PMC3290552-pone.0032232.s006.xls-MUC4-KD_vs_Mock-Unnamed_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MSH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.20958
ADH7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00512833
Xenobiotics	Reactome Pathways 2014	1.0	null
substantia nigra, pars reticulata, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.838509
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ESS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K43384508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16892
Fatty Liver	CTD Gene-Disease Associations	1.0	1.74963
hsa-miR-4468	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
MDA-MB-435 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.912
ZNF197	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22453
SOX17_OE_GDS3300_124_human_HESC (CA1 and CA2)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
florfenicol-6460	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC2962793__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE158834_1_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CCKBR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48358
GTEX-P78B-1326-SM-3P611	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08924
HT3	DepMap CRISPR Gene Dependency	1.0	3.25066
CRCGN017_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8232
BLTP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40252
GSE202434,GSE202438_12_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Myocardial Ischemia	DisGeNET Gene-Disease Associations	1.0	null
MMXD complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.567
Learning Disorders	CTD Gene-Disease Associations	1.0	1.59007
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.943549
BRD-K26306512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41236
Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)	Reactome Pathways 2014	1.0	null
Cerebral infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K21732483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59637
biological	GeneRIF Biological Term Annotations	1.0	null
BRD-K43389698_BMS-387032_A549_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A80213327_NSC 23766_WSUDLCL2_6.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ATG101	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39016
GSE155031_6_v_4_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
allelic	GeneRIF Biological Term Annotations	1.0	null
globally	GeneRIF Biological Term Annotations	1.0	null
k562	HPA Cell Line Gene Expression Profiles	-1.0	-1.05471
16024625-Table1	GeneSigDB Published Gene Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.855547
intermediate stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.68981
hydrogen	GeneRIF Biological Term Annotations	1.0	null
GTEX-WFON-2526-SM-3LK7P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
IMR-32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11705
reversal	GeneRIF Biological Term Annotations	1.0	null
stimulation	GeneRIF Biological Term Annotations	1.0	null
GSE216273,GSE216292_0_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE125014_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
alpha3-beta1 integrin-thrombospondin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.257
HT115	CCLE Cell Line Gene Expression Profiles	1.0	1.49545
TARDBP_KD_GDS3730_118_human_HEK293E	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE242199_6_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
All-trans-retinoic acid	HMDB Metabolites of Enzymes	1.0	null
Retinal ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
Renal proximal tubule epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.863
dorsolateral preisthmic part of periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58762
MELAS - Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes_Muscle - Striated (Skeletal) (MMHCC)_GSE1462	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.9449
Pulmonary artery endothelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.211
variants	GeneRIF Biological Term Annotations	1.0	null
PCGF4-22325352-293T-REX-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE242555_1_v_0_fn3k_human	RummaGEO Gene Perturbation Signatures	1.0	null
yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.175991
BRD-K58696904	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10317
Cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.383
CHD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00560231
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
extracellular region part	GO Cellular Component Annotations 2015	1.0	null
MAP3K7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05967
GTEX-XV7Q-0008-SM-4BRWL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
microarrays	GeneRIF Biological Term Annotations	1.0	null
JIMT1	CCLE Cell Line Gene CNV Profiles	1.0	2.21382
Subcutaneous adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.37
CDX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29339
individual	GeneRIF Biological Term Annotations	1.0	null
Dorsomedial nucleus of the hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37567
H3K4me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02375
GSE111247_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
carboxylic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
PKCA_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
icosanoid metabolic process	GO Biological Process Annotations 2023	1.0	null
LMNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25907
AMO-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
heart_6b	HPA Tissue Sample Gene Expression Profiles	1.0	0.916255
LRP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08646
Disease	Reactome Pathways 2014	1.0	null
posterobasal nucleus, intermediate part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02782
hsa-miR-577	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
benzathine benzylpenicillin-4140	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849334
NCIH684	CCLE Cell Line Gene Expression Profiles	1.0	1.74097
H3K9ac_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.402144
ZNF157	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2444
arachidonic acid epoxygenase activity	GO Molecular Function Annotations 2023	1.0	null
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.376
RAB17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.99804
BRD-K95763144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36794
Temporal association areas, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05593
BRD-K80568112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14039
GTEX-POMQ-2126-SM-2S1OJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
germ plasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.192423
GSE175787_13_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.05592
IL12RB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00561469
BRD-A19195498_TRIMIPRAMINE MALEATE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hypertension	GAD Gene-Disease Associations	1.0	null
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cyp2c82c	GeneRIF Biological Term Annotations	1.0	null
length	GeneRIF Biological Term Annotations	1.0	null
skeletal muscle cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.079181
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.507
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.26261
Aortic endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.242
OB outer plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.91268
BRD-K55665639	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37662
UPF3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06883
AR-21909140-LNCAP PROSTATE CANCER CELL LINES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
rs34971233	GeneRIF Biological Term Annotations	1.0	null
cellular lipid metabolic process	GO Biological Process Annotations 2015	1.0	null
linoleic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
MUC20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00464338
RNF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68761
Sarcoma_SARC_TCGA-WK-A8XO-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K34797601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.787
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.19045
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.84126
H3K9me3_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PHOX2B-30127528-KELLY-HUMAN-BRAINNEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Coronavirus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
H3K4me1_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
providing	GeneRIF Biological Term Annotations	1.0	null
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.062875
BRD-K79965790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.65657
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.311507
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H847	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.871502
liver	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.0484
vascular bundle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.15245
Mis6-Sim4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.858
glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.356341
LYL1-30185409-K562-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
BAZ2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73337
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QH-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054705
GTEX-SN8G-0226-SM-4DM6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941572
C1QTNF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06698
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.64381
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.144
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.177154
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
africanamericans	GeneRIF Biological Term Annotations	1.0	null
GTEX-XPVG-1826-SM-4B64X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875086
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	Reactome Pathways 2014	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A7R3-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8505-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
quinethazone-3793	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)	Reactome Pathways 2014	1.0	null
MYC_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRK-nu-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.43515
Hoxd13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.2991
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.28959
BRD-K48358706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91277
BRD-K29028138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34196
core of P-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.68079
calcium pantothenate-4189	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
promoter	GeneRIF Biological Term Annotations	1.0	null
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
UBE2D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26499
11,14,15-THETA	HMDB Metabolites of Enzymes	1.0	null
KASUMI1	DepMap CRISPR Gene Dependency	1.0	3.21
BRD-K36278687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36292
Paraventricular hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.617
carbohydrate metabolism disease	GWASdb SNP-Disease Associations	1.0	0.226299
BRD-K06994380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79764
Aorta	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.678
LNZTA3WT4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NFYA-21822215-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K89967940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14021
IALM	CCLE Cell Line Gene CNV Profiles	1.0	1.45714
PGF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0081395
arachidonic acid monooxygenase activity	GO Molecular Function Annotations 2023	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51N-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
independently	GeneRIF Biological Term Annotations	1.0	null
medial portion of STH	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.66536
assess	GeneRIF Biological Term Annotations	1.0	null
TCF7L2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3028
cerebellar cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02766
Perturb_2489_Mut_ESR1_SRP254635	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Lung adenocarcinoma_LUAD_TCGA-J2-A4AD-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFON-0526-SM-4LVLY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00533
BRD-K13390322_AT-7519_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K03353688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16439
Inward rectifying potassium channel	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.861
RPS6KB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04666
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC9290241-13058_2022_1547_MOESM2_ESM.xlsx-Foglio1-Supplementary_Table_S1_Differentially_expressed_transcripts_in_common_between_EPZ-_and_MI-2-treated_MCF-7_cells_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
fetal membrane	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071679
MDA-MB-468 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.963
ME2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63865
GTEX-QEL4-0526-SM-3GIJ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00424
thioperamide-4675	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-X5EB-1626-SM-4E3IV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36822
SHROOM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47948
DJM-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K26314798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77706
SETD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16358
CACO-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.913173
periventricular stratum of JcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15069
BRD-K57507729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02601
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
vitamin c_mus musculus_gpl6246_gse19378	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
21205295-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Creb5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.5945
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.69772
H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Stratum germinativum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.51
KIJ-265T cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.774
r8 part of lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24608
PMC10197848-12885_2023_10795_MOESM5_ESM.xlsx-Sheet1-ESR2_overexpressing_MCF7_cells_ESR2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A55416093_COLFORSIN_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.808
NCIH508	CCLE Cell Line Gene Expression Profiles	1.0	1.74312
lasalocid-6639	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.553683
PHF8-20622853-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ZNF716	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.04701
BRD-K23956364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31921
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05208
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K16929626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61169
PABPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63312
LS-180 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.921
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	58.4895
AP2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.269
SW403	CCLE Cell Line Gene Expression Profiles	1.0	1.453
GSE231524,GSE231526_0_v_1_dusp6_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K36662285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51412
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PMC6167382-41467_2018_6258_MOESM4_ESM.xlsx-TEAD-associated_GSC-Specific_UP-Nearest_Ensembl_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RWS6-0326-SM-2XCAP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26516
RANBP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47717
aromatase activity	GO Molecular Function Annotations 2015	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-6844-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K34005205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23623
BRD-K24700188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03288
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cardiomyopathy	GeneRIF Biological Term Annotations	1.0	null
improved	GeneRIF Biological Term Annotations	1.0	null
Vomiting	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K12347309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03847
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6436-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
g816g	GeneRIF Biological Term Annotations	1.0	null
PABPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93199
GTEX-U3ZM-0626-SM-4DXTV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.950068
Large luteal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.635
Paraventricular hypothalamic nucleus, magnocellular division, posterior magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.56551
GTEX-P44H-0326-SM-2XCES	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03578
organic cyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
smallintestine_4a	HPA Tissue Sample Gene Expression Profiles	1.0	0.952742
GTEX-SIU8-0426-SM-4BRUE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.939656
Stat5a::Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.2246
navicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27676
layer V of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.73716
BRD-A57762296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1127
heterocyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.086
cyp2j27	GeneRIF Biological Term Annotations	1.0	null
BRD-K74211805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76288
Prostate adenocarcinoma_PRAD_TCGA-J9-A8CN-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
reduced	GeneRIF Biological Term Annotations	1.0	null
BRD-K21206585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.45881
group	GeneRIF Biological Term Annotations	1.0	null
MXI1	ENCODE Transcription Factor Targets	1.0	null
integument	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE68925_1_v_0_fasudil_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12898
module	GeneRIF Biological Term Annotations	1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
BRD-K47498351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51807
GTEX-QESD-0526-SM-2I5G5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.998082
GTEX-QV31-0726-SM-3GAEG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.924287
GSE111247_14_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
UROtsa cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.847
benfotiamine-4312	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hematological	GAD High Level Gene-Disease Associations	1.0	0.293278
ZR751	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44495
arachidonate monooxygenase activity	GO Molecular Function Annotations 2025	1.0	null
SW156	DepMap CRISPR Gene Dependency	1.0	3.7894
GSE128730_0_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BPH-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XQ8I-0826-SM-4BOOE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900739
CERS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00546745
Nucleus ambiguus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09432
GTEX-W5X1-0826-SM-3GILN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58635
Maltose transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.954
BRD-K34703146	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44969
MET_knockdown_254_GSE38343	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-0.865726
Arachidonic Acid	CTD Gene-Chemical Interactions	1.0	null
GSE135030_11_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hypertrophy	CTD Gene-Disease Associations	1.0	1.04465
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956888
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.45
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
CEBPD	ENCODE Transcription Factor Targets	1.0	null
trichostatin A-5908	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7075-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-UJMC-0426-SM-4IHJF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01237
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
rare	GeneRIF Biological Term Annotations	1.0	null
ZNF548	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26405
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	GO Molecular Function Annotations 2015	1.0	null
BRD-K99545815_PF-562271_BT20_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
there	GeneRIF Biological Term Annotations	1.0	null
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046771
respect	GeneRIF Biological Term Annotations	1.0	null
TCL1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6009
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054721
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
fastigial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.8475
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.835
GTEX-Q2AH-1726-SM-3NB2B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1446
GTEX-XUZC-0926-SM-4BOQF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02479
CLIC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00487364
CRCGN016_MCF10A.WT.HP_24H:O24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0046
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
HYCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.55234
PTGES3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6206
SP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.835621
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE90552_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SK-MEL-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14902
cytoplasm	GO Cellular Component Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7540-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4018
POP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18524
arachidonate epoxygenase activity	GO Molecular Function Annotations 2025	1.0	null
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.293
Cocaine	CTD Gene-Chemical Interactions	1.0	null
Arachidonate Epoxygenase / Epoxide Hydrolase(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
GSE139016_3_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE258991_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A3MG-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-U8XE-1026-SM-4E3HM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
BRD-K32118188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48849
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Nr2e1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.6785
GSE210476_11_v_6_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
HINFP	JASPAR Predicted Transcription Factor Targets	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A2-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K43389698_BMS-387032_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
linoleic acid epoxygenase activity	GO Molecular Function Annotations 2023	1.0	null
bounding membrane of organelle	GO Cellular Component Annotations 2015	1.0	null
sarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.080912
Taenia tecta, ventral part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3314
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.615377
Lung adenocarcinoma_LUAD_TCGA-86-7955-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0814
H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZNF93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7929
17660535-TableS4c	GeneSigDB Published Gene Signatures	1.0	null
GTEX-XQ3S-0626-SM-4BOOB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891168
BRD-K17953061_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COX7B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00548084
MYO1E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76691
Jejunum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.283
CRCGN015_HEPG2_48H:H06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05814
Codeine	HMDB Metabolites of Enzymes	1.0	null
RILP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11794
Linoleic acid	MW Enzyme Metabolite Associations	1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of blood circulation	GO Biological Process Annotations 2025	1.0	null
BRD-K44298652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0854
GSE221577_1_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
r9 portion of ambiguous motor nucleus (postmigratory)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44078
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE178714_6_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SDC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00539029
posteroventral (inferior) parietal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.891086
GTEx AdrenalGland 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	3.14323
cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.44129
characterization	GeneRIF Biological Term Annotations	1.0	null
NCI-SNU-5	GDSC Cell Line Gene Expression Profiles	-1.0	-1.71211
BRD-K49075727_nintedanib_HME1_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A79768653_sirolimus_HME1_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K56870337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03233
chain	GeneRIF Biological Term Annotations	1.0	null
RT4	CCLE Cell Line Gene Expression Profiles	1.0	2.33159
PMC9287735-mmc8.xlsx-MI_Related_Genes-TNF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K00615600_AG14361_AGS_6.0_h_25.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
lidoflazine-6278	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.334498
GTEx Brain 20-29 vs 40-49	GTEx Tissue-Specific Aging Signatures	1.0	5.88506
BRD-K88573743_A443654_MDAMB231_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K83190598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03948
females	GeneRIF Biological Term Annotations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-V1-A8MM-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10154349-41418_2023_1142_MOESM6_ESM.xlsx-Sheet1-Supplementary_data_3_Genes_positively_correlated_with_HOXC13-AS_in_skin_granular_cells_correlation_coefficients_cor_0_FDR_0_05_HOXC13	Rummagene Transcription Factor Associations 2026	1.0	null
using	GeneRIF Biological Term Annotations	1.0	null
SNU840	CCLE Cell Line Gene CNV Profiles	1.0	2.35717
regulation of system process	GO Biological Process Annotations 2015	1.0	null
SW982	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-OXRP-2426-SM-2S1NR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
B2M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41528
heme binding	GO Molecular Function Annotations 2015	1.0	null
CHRNB4_Deficiency_GDS2309_714_mouse_Brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
bronchus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.423818
BDCA4+_DentriticCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.27657
ACAT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00347425
BRD-K02329600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02303
macrophages	GeneRIF Biological Term Annotations	1.0	null
BRD-K13390322_AT-7519_MDAMB231_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5099-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
key	GeneRIF Biological Term Annotations	1.0	null
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18059
RBL1_KO_GDS1932_739_mouse_Neurospheres	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6939-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IL2RB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00516008
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.921822
insulin	GeneRIF Biological Term Annotations	1.0	null
Alzheimer Disease	DisGeNET Gene-Disease Associations	1.0	null
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10728
vasculature	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.525166
BRD-K02827191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49879
phenyl-aminosalicylate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84804
BRD-K31059261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89532
WM278	COSMIC Cell Line Gene Mutation Profiles	1.0	null
postischemic	GeneRIF Biological Term Annotations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-FC-A5OB-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Primary somatosensory area, trunk, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1106
Weight Gain	CTD Gene-Disease Associations	1.0	1.10459
BRD-K74712962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48911
FRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88601
pronetalol-3984	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-X5EB-1026-SM-46MVU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
plant embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.072877
hsa-miR-4511	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
BRD-K70549064_EI-156_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WY7C-0526-SM-3NB3D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52831
SCARB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06115
DMAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15273
reuniens nucleus, main part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07383
OVCA 420	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.40458
GTEX-U8T8-2326-SM-3DB96	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836589
arachidonic acid epoxygenase activity	GO Molecular Function Annotations 2015	1.0	null
PANC1005	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47331
BRD-K05939258	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23532
CARD19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5173
incident	GeneRIF Biological Term Annotations	1.0	null
disopyramide-7035	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.238
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.30968
BRD-K13390322_HY-50940_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
distribution	GeneRIF Biological Term Annotations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-75-6207-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
tetrandrine-5821	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A86550573	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.8271
GSE165334_2_v_0_dabrafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
fusaric acid-3986	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SF-539 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.615
developing	GeneRIF Biological Term Annotations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-97-7941-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBXN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9156
BRD-K72437469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11767
Lung adenocarcinoma_LUAD_TCGA-78-7535-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9161725-Table_4.xlsx-EHF-CSAG1_EHF	Rummagene Transcription Factor Associations 2026	1.0	null
MDA-MB-175-VII	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.76687
Endoplasmic reticulum subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
NCI-H2066	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-RU72-0326-SM-2TF5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48957
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.4951
BRD-K13390322_AT-7519_HME1_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CD19+_BCells(neg._sel.)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.69194
BRD-K23442578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24122
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30485
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DIS3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50492
tanespimycin-5585	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CASKIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28323
HCC2998	BioGPS Cell Line Gene Expression Profiles	1.0	1.67882
minor	GeneRIF Biological Term Annotations	1.0	null
BRD-K06614664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57124
TEKT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92586
intestine	GeneRIF Biological Term Annotations	1.0	null
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.44476
H9c2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.313
Foxf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.5895
H3K9ac_Rectal Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FLNA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77218
BRD-K98320707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11344
tetrapyrrole binding	GO Molecular Function Annotations 2015	1.0	null
cortical collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.838252
FNIP-folliculin RagC/D GAP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.532
nephron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.859258
BRD-A89846380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65152
TNK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.44576
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.298
PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-TFAP4_TFAP4	Rummagene Transcription Factor Associations 2026	1.0	null
U-373MG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.616
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.2642
Secondary motor area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48348
SP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.959965
GTEX-PLZ6-0626-SM-3P61B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16251
molt4	HPA Cell Line Gene Expression Profiles	-1.0	-1.05471
ESPN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14341
outer SZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.84044
Primary somatosensory area, barrel field, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30244
CD300C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00574664
PMC6932815-ppat.1007634.s014.xlsx-ST4_DGE_ELF1-R8AvIFN6-mock_lfc2-external_gene_name_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.3757
POU3F4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85117
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12868
MDAMB361	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.762314
atp-sensitive potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.736464
heart_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.39004
BRD-K37949240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68017
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
Posterior parietal association areas, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26296
KDM4A	ENCODE Transcription Factor Targets	1.0	null
NDUFB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21235
GTEX-QCQG-1826-SM-2S1P2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
H3K27me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vary	GeneRIF Biological Term Annotations	1.0	null
8,9-Epoxyeicosatrienoic acid	HMDB Metabolites of Enzymes	1.0	null
PMC5629025-elife-27159-fig1-data1.xlsx-Direct_AR_target_genes-Control_only_down-regulated_genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152734,GSE152735_2_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K95943192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54316
AMBRA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53316
BRD-K30269093	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1803
GSE139540_0_v_1_menadione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OB olfactory fiber layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	4.18926
MAPKAPK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00341096
TCF23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50657
Retrosplenial area, lateral agranular part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.30189
GSE242083,GSE242098_3_v_4_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.0435
BRD-K87909389_alvocidib_HS578T_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SRY-25088423-EMBRYONIC GONADS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K10707948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19428
mRNA_ASCL1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
superior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.974569
BRD-K14200658_Syrosingopine_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAP3K7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00760429
Lung squamous cell carcinoma_LUSC_TCGA-21-1078-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
11,12-EpETrE	MW Enzyme Metabolite Associations	1.0	null
14,15-EpETrE	MW Enzyme Metabolite Associations	1.0	null
Cardiac muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.06
downregulation	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6645
BRD-K13719101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02353
GSE149035_1_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
markedly	GeneRIF Biological Term Annotations	1.0	null
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
11,12-Epoxyeicosatrienoic acid	HMDB Metabolites of Enzymes	1.0	null
BRD-K92239253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40888
Arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
considered	GeneRIF Biological Term Annotations	1.0	null
PTGFRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24381
blood	GeneRIF Biological Term Annotations	1.0	null
GTEX-OHPN-0226-SM-48TBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
NCIH1755	DepMap CRISPR Gene Dependency	1.0	2.75032
MYCN-27167114-CHIP-SEQ-NEUROBLASTOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-REY6-2426-SM-48FF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903827
Pterinosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.862
smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.1616
ZNF419	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32712
DPP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12565
ephx2	GeneRIF Biological Term Annotations	1.0	null
H3K4me1_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE198434_1_v_0_aspirin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XUJ4-0326-SM-4BOP9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01089
H3K27me3_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Down_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.3217
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81W-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9253713-mmc3.xls-sufu_KD_HCC1954_DEGs-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
inner CP in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.929215
Cardiomegaly	CTD Gene-Disease Associations	1.0	1.09646
H3K9ac_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-5635-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFON-0226-SM-3GIKR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48292
Prdm15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.6084
Hyperhomocysteinemia	DisGeNET Gene-Disease Associations	1.0	null
PCBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39696
CRCGN017_MCF10A.TP53.M_24H:E12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16177
MAX	ENCODE Transcription Factor Targets	1.0	null
KMS20	CCLE Cell Line Gene CNV Profiles	-1.0	-1.81147
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HRH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37959
meclofenoxate-3707	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
arsenic trioxide	CTD Gene-Chemical Interactions	1.0	null
Oligospermia	CTD Gene-Disease Associations	1.0	1.38071
substrate	GeneRIF Biological Term Annotations	1.0	null
profile	GeneRIF Biological Term Annotations	1.0	null
Arterial endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.802
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
only	GeneRIF Biological Term Annotations	1.0	null
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825437
younger	GeneRIF Biological Term Annotations	1.0	null
J5 hepatoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.29
GSE182179_5_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
Hepatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.105
BRD-K41674016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06102
TMEM68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64483
CRCGN009_HEPG2_24H:F11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15415
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E7-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Stomach	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.587495
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.018
nanodiscs	GeneRIF Biological Term Annotations	1.0	null
epoxygenase	GeneRIF Biological Term Annotations	1.0	null
PRB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3292
intracellular part	GO Cellular Component Annotations 2015	1.0	null
BCKDK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13869
Taenia tecta, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56958
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.873115
GTEX-XLM4-2026-SM-4AT4X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44734
BRD-K18139667	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47762
Nucleus ambiguus, ventral division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12792
Temporal association areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15644
5114445-901	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE142210_11_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
Myocardial Infarction	DisGeNET Gene-Disease Associations	1.0	null
Intestinal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.655
Hoxc13_OE_GDS1890_174_mouse_Skin	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
HLMVEC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.836
SLX9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39191
Chromosome Aberrations	CTD Gene-Disease Associations	1.0	1.46883
BRD-K16682693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13321
Metabolism	Reactome Pathways 2014	1.0	null
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.838533
GTEX-X4LF-1726-SM-3NMBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13282
GTEX-XPVG-0826-SM-4B654	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42243
Perturb_11474_OE_SOX9_SRP341040	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.71556
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A8P1-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FDX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51647
sf-21 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.322597
PMC3713213__F7	PFOCR Pathway Figure Associations 2024	1.0	null
myocardial infarction; stroke	GAD Gene-Disease Associations	1.0	null
GSE207301,GSE207303_1_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2716-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Heart Failure	DisGeNET Gene-Disease Associations	1.0	null
lingual gyrus, left, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.855176
CA2 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.54096
arachidonic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0251
GTEX-U3ZN-0426-SM-4DXSH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.988119
vein disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.098939
Primary somatosensory area, unassigned, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27913
meticrane-1671	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
K562	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.51172
biological regulation	GO Biological Process Annotations 2015	1.0	null
BRD-K73183447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00919
VMRCLCP	CCLE Cell Line Gene CNV Profiles	1.0	1.93159
Neoplasms	CTD Gene-Disease Associations	1.0	1.41146
decreased circulating estrogen level	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-A52530684_DOXORUBICIN_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K52136059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3482
GTEX-XPT6-0126-SM-4B65S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48684
JUN	ENCODE Transcription Factor Targets	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8339-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE223908,GSE223909_4_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MLNR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00513543
lung epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.169737
GSE135030_8_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Atherosclerosis	CTD Gene-Disease Associations	1.0	1.11945
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H0-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FS-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
troglitazone-462	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
GR-ST	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10957658__F4	PFOCR Pathway Figure Associations 2024	1.0	null
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Corm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.511
transgenic	GeneRIF Biological Term Annotations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A5EY-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
periventricular stratum of m1AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78785
BRD-K98474331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47848
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Levomilnacipran	DrugBank Drug Targets	1.0	null
Primary motor area, Layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3497
BRD-K15615178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71549
BRD-K70380532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84641
selective	GeneRIF Biological Term Annotations	1.0	null
Steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.502
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
acute coronary syndrome	GAD Gene-Disease Associations	1.0	null
GSE87617_1_v_0_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K35945596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90829
A-61603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22595
USF1_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17899371-GeneTable4	GeneSigDB Published Gene Signatures	1.0	null
TMEM125	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.917
SEPTIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36253
Cystitis	CTD Gene-Disease Associations	1.0	1.13963
BRD-K86792405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25546
GTEX-U412-0526-SM-3DB9I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849939
NCI-H650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00008
PMC4494960-oncotarget-06-12587-s002.xlsx-LNCaP_MYC_Microarray-Table_S1_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
CW2	CCLE Cell Line Gene Expression Profiles	1.0	1.96679
Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FS-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-VUSG-2826-SM-4KKZM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
serine-type peptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.469
16166618-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
ETV1-20927104-GIST48-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.931017
MalFGK2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.125
GSE193993_1_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3365-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tagsingle	GeneRIF Biological Term Annotations	1.0	null
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
been	GeneRIF Biological Term Annotations	1.0	null
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.312
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.76
skbr3	HPA Cell Line Gene Expression Profiles	1.0	1.06414
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WR-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QV31-1626-SM-2S1QC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.85388
Pulmonary artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.188
GSE232558_0_v_1_fbxl12_human	RummaGEO Gene Perturbation Signatures	1.0	null
15897907-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-UJMC-0526-SM-3GAE3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3399
GTEX-WHPG-0826-SM-3NMBF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44798
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_and_sensitivity_analysis_for_IPF_susceptibility_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11551338-pnas.2411189121.sd01.xlsx-VDR-Unnamed_0_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
ventrolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.73029
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RN-01A-12R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A2-11A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUN_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
highlight	GeneRIF Biological Term Annotations	1.0	null
Gfi1b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.4702
BRD-K61182411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55218
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
pimethixene-7468	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
HCC1419	CCLE Cell Line Gene Expression Profiles	1.0	1.36945
vitro	GeneRIF Biological Term Annotations	1.0	null
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PSN1	DepMap CRISPR Gene Dependency	1.0	2.34984
BRD-K21180458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77826
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.749
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.436
H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K53127431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42244
inferred	GeneRIF Biological Term Annotations	1.0	null
GSE197850_4_v_2_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
KIF20A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53773
MHH-NB-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16405
felodipine-3295	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
flupentixol-5307	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K75331656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29429
MPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40427
Cardiac muscle fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.029
BRD-K49307935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72654
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7595-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K23835343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18636
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.449
GTEX-XYKS-0226-SM-4BRW3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25665
Brain Lower Grade Glioma_LGG_TCGA-WH-A86K-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22388
increased vasoconstriction	MGI Mouse Phenotype Associations 2023	1.0	null
pomalidomide	CTD Gene-Chemical Interactions	1.0	null
p466l	GeneRIF Biological Term Annotations	1.0	null
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.943549
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10275
BRD-K50046044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0445
Metabolic dysfunction-associated steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.386
BRD-K56405136	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3184
IKZF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64067
Sarcoma_SARC_TCGA-X6-A7WB-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:A21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25145
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-1726-SM-4BONW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
hsa-miR-944	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.786
CAMA1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.86649
DAUNORUBICIN LIPOSOMAL	DGIdb Drug Targets 2026	1.0	0.2005
SW780	GDSC Cell Line Gene Expression Profiles	1.0	1.43943
GSE147366_1_v_4_med13_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K45712538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14076
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.269
tranylcypromine-7293	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Abnormalities, Multiple	CTD Gene-Disease Associations	1.0	1.07732
HT1376	DepMap CRISPR Gene Dependency	1.0	6.90236
Anterodorsal preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41177
Cytochrome P450 - arranged by substrate type	Reactome Pathways 2014	1.0	null
inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.996372
xenobiotic metabolic process	GO Biological Process Annotations 2015	1.0	null
KCNH5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0045863
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4797-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.446
Nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Subparaventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.69289
COQ4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86309
BRD-K79090631_CGP-60474_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-UTHO-2426-SM-4JBHD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830155
Human brain microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.963
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18443
attention deficit disorder; conduct disorder; oppositional defiant disorder	GAD Gene-Disease Associations	1.0	null
PARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40971
H3K9ac_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cell periphery	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.311851
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K83972459_JWE-035_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DMS-53	COSMIC Cell Line Gene CNV Profiles	1.0	2.12225
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12076
BRD-K50247051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17664
saquinavir-5770	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
respiratory mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.174735
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.940294
Primary somatosensory area, unassigned, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5125
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.90714
BRD-K79090631_CGP-60474_HA1E_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC10794847-mmc5.xlsx-PIAS1_KD_down-Table_S4_Differentially_expressed_genes_with_PIAS1_knockdown_in_the_progenitors_state_Related_to_Figure_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MAP2K1_knockdown_134_GSE31534	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.49183
BRD-K39176069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22226
arachidonic acid metabolism	KEGG Pathways	1.0	null
psych	GAD High Level Gene-Disease Associations	1.0	0.293278
TET3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.37345
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RV-02A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Intracranial berry aneurysm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
HIRIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16744
posteroventral (inferior) parietal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.988033
BATF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24479
CBX2-22325352-293T-REX-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.507
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.92767
GTEX-U3ZH-0426-SM-4DXSE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03113
BL2756 (CRABP2)	NURSA Protein Complexes	1.0	null
ATP5MG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15039
NOM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42354
biology	GeneRIF Biological Term Annotations	1.0	null
BRD-A13122391_16-HYDROXYTRIPTOLIDE_A375_24.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-7660-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
small_intestine	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.55362
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K00557942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1311
Hyperplasia	CTD Gene-Disease Associations	1.0	1.35328
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	2.082
17638894-Table2	GeneSigDB Published Gene Signatures	1.0	null
Testosterone sulfate	HMDB Metabolites of Enzymes	1.0	null
respiratory system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.604099
firstpass	GeneRIF Biological Term Annotations	1.0	null
BRD-K90882192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16486
GSE158182_5_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
phagocytosis	GeneRIF Biological Term Annotations	1.0	null
Umbilical vein endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.582
RAB18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84957
adrenal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.105276
A-CA-04-2009(H1N1)_6Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.88924
GSE195514_0_v_1_stk25_human	RummaGEO Gene Perturbation Signatures	1.0	null
TDRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41111
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.919499
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MASP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77132
BRD-K65464642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17364
Leukemialymphoblastic(MOLT-4)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.866258
COVID-19	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
GTEX-SJXC-1226-SM-4DM78	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17018
TOPBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45249
Specific developmental disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.603
BRD-K81982648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10768
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HD-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
oxaprozin-3794	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
octreotide	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22174
BRD-K13074426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77621
GET complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.921
BRD-K83122599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38063
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.603
6-Hydroxymelatonin	HMDB Metabolites of Enzymes	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7177-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KMS-28BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.60009
OTUD6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99893
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12775252-18_2025_5991_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_2_Up-_and_down-regulated_genes_in_TCF7L2-depleted_EVT_compared_to_control_EVT_TCF7L2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K57472585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49184
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.374243
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05397
ADGRG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79734
microcellular tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.83258
hepatoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081306
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.030006
hsa-miR-3124-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GSE213650_3_v_2_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
NR2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.5673
GTEX-OXRK-0826-SM-2HMK7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52269
SLC32A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00626499
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.565508
BRD-K67390061	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49781
UNC93B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06379
BRD-K56065989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13361
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SNU1033	DepMap CRISPR Gene Dependency	1.0	2.90791
ZNF324	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6425
KLHL31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67319
H3K9me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
indoprofen-3345	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Anteromedial visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.89049
UM-UC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.843742
TP53_01_31	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60101
Insulin Resistance	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE215849_2_v_1_muc1_human	RummaGEO Gene Perturbation Signatures	1.0	null
myometrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.23961
infarctions	GeneRIF Biological Term Annotations	1.0	null
KPNRTBM1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.41398
seedling	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.072877
SNU1105	DepMap CRISPR Gene Dependency	1.0	2.96347
NAMALWA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.074537
GSE139540_0_v_2_menadione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FLI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54916
GSE261563_6_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
Macula densa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.674
MNT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00491349
GTEX-U3ZN-2126-SM-4DXU1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896782
Colon ascendens	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.748
nalidixic acid-7367	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K06029218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36738
LS513	CCLE Cell Line Gene Expression Profiles	1.0	2.45768
Edema	HuGE Navigator Gene-Phenotype Associations	1.0	null
Main olfactory bulb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.62443
GTEX-PX3G-2026-SM-48U1H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11164
GTEX-PW2O-1926-SM-2S1OB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989324
GTEX-REY6-1126-SM-48FDU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
GTEX-P78B-0426-SM-2I5F5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73792
BRD-K63645840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40044
CHP-212	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.02234
JIMT-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.45126
Prostate adenocarcinoma_PRAD_TCGA-EJ-5504-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE230573_1_v_0_dcaf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SUV39H2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32928
H3K27me3_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EOL-1-CELL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tumors	GeneRIF Biological Term Annotations	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
organelle	GO Cellular Component Annotations 2015	1.0	null
GSE210101,GSE210114_5_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF487	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58344
PMC11684804-jci-135-174981-s193.xlsx-DESeq2_pseudobulk_AA_Ag_vs_Pre-Gene_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
SNRNP48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07268
SK-UT-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
pparalpha	GeneRIF Biological Term Annotations	1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
GSE146687_2_v_0_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
catabolic process	GO Biological Process Annotations 2015	1.0	null
GSE235066_4_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242290_1_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195568_6_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE155031_5_v_0_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
ebselen-3458	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
integral component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.185469
18199535-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
RER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35235
BRD-A20697603_598226_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10214
outer CP in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.33425
ovary cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.075377
BRD-K89952634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49292
RASIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07796
liminal reticular formation of m2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.106
atherosclerosis, coronary	GAD Gene-Disease Associations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AB-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Vascular smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.61
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12251
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K76910883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23686
disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.370368
Agranular insular area, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.07966
HSC-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K87909389_alvocidib_HS578T_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
etomidate-7460	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K79090631_CGP-60474_MCF10A_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
liver_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.01223
RPUSD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10643
BRD-K99122228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1722
GSE153871_4_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
17660535-TableS4a	GeneSigDB Published Gene Signatures	1.0	null
A204	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.00864
GTEX-X261-0011-R5A-SM-3NMB4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02141
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K49742819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01761
OS-RC-2	GDSC Cell Line Gene Expression Profiles	1.0	1.79233
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
steroid hydroxylase activity	GO Molecular Function Annotations 2015	1.0	null
onset	GeneRIF Biological Term Annotations	1.0	null
mongolian	GeneRIF Biological Term Annotations	1.0	null
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
properties	GeneRIF Biological Term Annotations	1.0	null
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-0.824472
GSE154253_1_v_0_tnfaip8_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8387919-mmc2.xlsx-ST8_NEUROG3_and_islets_expr-Unnamed_2_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11058205-42003_2024_6202_MOESM6_ESM.xlsx-Data3b_DirectGene_FOXA1-Data3b_Genes_directly_regulated_by_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
Posterior parietal association areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37319
SF-9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.212
TLN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.48956
POU2AF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73155
GYG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51791
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87909389_alvocidib_HS578T_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
linoleic acid metabolism	KEGG Pathways	1.0	null
GSE138863_2_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
meteneprost-7552	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SQLE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02354
Immune System Diseases	CTD Gene-Disease Associations	1.0	1.33642
SKOV3	BioGPS Cell Line Gene Expression Profiles	1.0	0.857089
PMC7481169-277_2020_4194_MOESM9_ESM.xlsx-RUNX1_R139G-RUNX1_R139_mutant_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195559_6_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
solanine-2808	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.092
BRD-K13672060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.48688
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ST13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.93631
CPHXL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63257
LD-69-ZV56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201867
modifications	GeneRIF Biological Term Annotations	1.0	null
OB glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.68051
H3K4me3_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-RTLS-0826-SM-2TF5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22033
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.62281
Anterolateral visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01578
arachidonic acid 14,15-epoxygenase activity	GO Molecular Function Annotations 2015	1.0	null
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.41662
BRD-K08416835	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05855
fetus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058115
SKIL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0075707
GTEX-QEL4-1226-SM-447A4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967549
BronchialEpithelialCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-3.26797
MOG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00677646
WM115	DepMap CRISPR Gene Dependency	1.0	2.34624
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.810276
globus pallidus, internal segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11226
BRD-K08903301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67079
COLO668	CCLE Cell Line Gene CNV Profiles	1.0	1.7763
Lung squamous cell carcinoma_LUSC_TCGA-56-8309-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K12175788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26401
BRD-K19220233_JNK-9L_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A87Q-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K01225247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04215
hypocotyl	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.074582
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14375
PRPF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49453
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Arachidonic acid metabolism	KEGG Pathways 2026	1.0	null
globus pallidus, external segment, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.13452
GTEX-OIZH-3026-SM-3NB1G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881806
BRD-K91511557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84838
retrohypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45618
SUM225CWN	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.75891
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BUB1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00502584
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
endoplasmic reticulum	LOCATE Predicted Protein Localization Annotations	1.0	null
Lung Neoplasms	CTD Gene-Disease Associations	1.0	1.15661
BRD-K79090631_CGP-60474_MCF10A_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE158834_2_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PWOO-0526-SM-2S1Q3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16143
unsaturated fatty acid metabolic process	GO Biological Process Annotations 2023	1.0	null
CXCL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90531
Brain Lower Grade Glioma_LGG_TCGA-VM-A8C8-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K08409548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22234
Zfx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	45.5609
EFCAB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.00577
CRCGN015_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35157
implicates	GeneRIF Biological Term Annotations	1.0	null
metabolic	GAD High Level Gene-Disease Associations	1.0	0.298214
BRD-K50423606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09624
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1045
GTEX-SNMC-0126-SM-2XCFO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72371
related	GeneRIF Biological Term Annotations	1.0	null
tissue	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_CD19 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BAEC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.466
H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
medial nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.36008
BRD-K51760683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66212
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.2642
LHX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31505
GSE210870_0_v_2_snai1_human	RummaGEO Gene Perturbation Signatures	1.0	null
skeletal muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.077626
ADRA2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00518788
PEX19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77889
hsa-miR-548ag	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
H3K27me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EW16	DepMap CRISPR Gene Dependency	1.0	5.33097
H3K4me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060502
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K68574010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00517
GTEX-SSA3-0326-SM-32QPS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09214
peduncular part of dorsomedial hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44257
GSE123861_1_v_0_sin3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NZM3	DepMap CRISPR Gene Dependency	1.0	2.88498
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CDX2-21074721-CACO-2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MPLKIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.94046
2'-(glutathion-S-yl)-deschlorodiclofenac	CTD Gene-Chemical Interactions	1.0	null
EVI1-22308434-SKOV3-HUMAN-OVARY-OVARIANCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_6697_KD_LAD1_SRP117048	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.77577
CBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22289
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.55329
Runx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.767
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6960-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
eight	GeneRIF Biological Term Annotations	1.0	null
support	GeneRIF Biological Term Annotations	1.0	null
SIX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08422
Glaucoma	DisGeNET Gene-Disease Associations	1.0	null
GSE122425_1_v_0_nsun2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.663
H3K4me1_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K52139780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24741
BRD-K97462883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12734
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03583
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A719-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ENOX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00608462
BRD-K17232330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29418
astemizole	GeneRIF Biological Term Annotations	1.0	null
CDC27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72591
Secondary motor area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.48155
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14095
Heart Defects, Congenital	CTD Gene-Disease Associations	1.0	1.29843
BDKRB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00637657
polymorphisms	GeneRIF Biological Term Annotations	1.0	null
BRD-K32145037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76341
CP in rostral hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23141
MRPL19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11983
Cardiofibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.143
BRD-K79090631_CGP-60474_BT20_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-140	COSMIC Cell Line Gene Mutation Profiles	1.0	null
p450	GeneRIF Biological Term Annotations	1.0	null
GSE235587_2_v_1_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ltype	GeneRIF Biological Term Annotations	1.0	null
BRD-K65496998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71637
hypertrophy	GeneRIF Biological Term Annotations	1.0	null
CCDC124	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48373
GSE203329_0_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Defective FMO3 causes Trimethylaminuria (TMAU)	Reactome Pathways 2014	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3L7-01A-21R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Venous blood cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.505
H3K27me3_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Subcutis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.354
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15735
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K9me3_U2OS_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A63382799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29448
H3K4me1_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE98898_7_v_2_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NUDT15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69592
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03219
ukrainian	GeneRIF Biological Term Annotations	1.0	null
GTEX-OXRO-0226-SM-3LK6F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
GSE135030_3_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
caudal subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12748
GTEX-OHPL-2026-SM-3TW8R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952953
BRD-K42995703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14567
heart endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.249977
EGLN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00581347
POLB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00538049
OCIP5X	DepMap CRISPR Gene Dependency	1.0	7.10967
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03643
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.27843
Angioedema	CTD Gene-Disease Associations	1.0	1.03939
Liver hepatocellular carcinoma_LIHC_TCGA-XR-A8TF-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KCNC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08389
CENPO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45888
GTEX-RUSQ-1926-SM-2TF6K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850523
Villous trophoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.621
BRD-K69082321	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11145
TSPAN17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60282
BRD-K72414522_AZD-5438_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TOM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80321
Obesity	HuGE Navigator Gene-Phenotype Associations	1.0	null
pirinixic acid-464	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE158975_0_v_1_spp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ4-0008-SM-48TE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00998
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Cardiomyoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.76
H3K27ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
rottlerin-825	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Guanylate cyclase complex, soluble	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.102
metabolic process	GO Biological Process Annotations 2015	1.0	null
AP1M1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18684
TT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.675765
KM-H2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K9me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K58756877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7143
increased systemic arterial systolic blood pressure	MGI Mouse Phenotype Associations 2023	1.0	null
Metabolism	Reactome Pathways 2024	1.0	null
GTEX-X4EP-0326-SM-3P5Z6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59306
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.333218
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO Molecular Function Annotations 2015	1.0	null
TAL1-30185409-K562-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.898
POR_KO_GDS1678_762_mouse_Jejunum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K60044070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23163
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1741
cerebellar cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.871682
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.546
GTEX-XLM4-0426-SM-4AT54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
Retinal microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.666
GTEX-RM2N-1826-SM-2TF5B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.28333
acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.327375
BRD-K63299476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0547
Heart valve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.816
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A439-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.895073
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32666
CRCGN010_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62342
fatty acid metabolic process	GO Biological Process Annotations 2015	1.0	null
COLO679	DepMap CRISPR Gene Dependency	1.0	3.55613
type	GeneRIF Biological Term Annotations	1.0	null
perhexiline-7441	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE214931_1_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K70870890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06992
Lateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1693
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-2W-A8YY-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4487	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Essential hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.674
MARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66308
BRD-K95578456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65232
16(R)-HETE	HMDB Metabolites of Enzymes	1.0	null
Snowflake Vitreoretinal Degeneration	DisGeNET Gene-Disease Associations	1.0	null
responses	GeneRIF Biological Term Annotations	1.0	null
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2742
Retrosplenial area, lateral agranular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20518
ATP2C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63439
GSE195568_3_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
outcomes	GeneRIF Biological Term Annotations	1.0	null
SCG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67403
GSE175787_13_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
LN18	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.954269
BRD-K28932578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32893
Ventricular Fibrillation	CTD Gene-Disease Associations	1.0	1.12323
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.996
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KLF6-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Bed nucleus of the anterior commissure	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03846
RBL1_KO_GDS1931_740_mouse_Neurospheres (MG-430A)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5478-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NFIX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.3998
transient Purkinje cell clusters	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.19643
shell of P-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39297
0297417-0002B-6895	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K47349225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66493
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.958
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.970211
upper (rostral) rhombic lip_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.934804
GTEX-X8HC-0226-SM-4E3K1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03806
drug catabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ACLY	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00454376
KLHL34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94119
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7X5-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATAD2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22569
GSE128730_3_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Macrophage foam cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.556
CHP134	DepMap CRISPR Gene Dependency	1.0	2.17565
GTEX-PWN1-0226-SM-2S1OZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
linoleic acid epoxygenase activity	GO Molecular Function Annotations 2015	1.0	null
lipid	GeneRIF Biological Term Annotations	1.0	null
clearly	GeneRIF Biological Term Annotations	1.0	null
ZNF821	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25114
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.992691
aortic endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.305361
BRD-K31801624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35603
GTEX-XGQ4-0326-SM-4GIEE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33542
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.983112
Perturb_8991_KD_EGR2_SRP407074	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.00629
RBBP5	ENCODE Transcription Factor Targets	1.0	null
Ovary	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.06879
H3K4me3_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
superficial stratum of r8BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22733
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.778
bumetanide-5117	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
eye and adnexa disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043844
RAP2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92993
BRD-K68383485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13127
GSE133927_1_v_0_meox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
18497862-TableS4	GeneSigDB Published Gene Signatures	1.0	null
BRD-K73523458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1904
BRD-K72636697_QL-X-138_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K96799727_Pifithrin- ?_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
OS252	DepMap CRISPR Gene Dependency	1.0	5.80229
BRD-K04269696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16208
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00903
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A5A3-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QESD-1526-SM-2S1QT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0713
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A6SH-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XUW1-1526-SM-4BOOY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02499
GTEX-OOBJ-0826-SM-3NB2K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17395
Acute Myeloid Leukemia_LAML_TCGA-AB-2824-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RFT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76383
LY-294002-6956	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
End stage renal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.293
GTEX-Q2AG-1126-SM-48U1P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878851
single-organism process	GO Biological Process Annotations 2015	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-US-A776-01A-13R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-TMMY-1726-SM-4DXTD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95434
BRD-K96258717	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77605
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RF-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K43306617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27474
interindividual	GeneRIF Biological Term Annotations	1.0	null
BRD-K87340219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6763
PMC11716045-peerj-13-18816-s007.xlsx-Sheet1-ZNF440_ZNF440	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30264389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28745
CRCGN015_MCF10A_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.07096
H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K43594798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38584
NOS1	DepMap CRISPR Gene Dependency	1.0	2.63063
mediodorsal nucleus of thalamus_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.86568
GTEX-PWCY-0526-SM-2I3ER	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4604
Paraxanthine	HMDB Metabolites of Enzymes	1.0	null
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ERH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11025
Squamous Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
MALME3M	DepMap CRISPR Gene Dependency	1.0	2.42423
BRD-A50913845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12106
GSE158834_10_v_5_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Neointima	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.008
BRD-K98384558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16301
Smc5-Smc6 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.791
isotretinoin-7438	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	2.14202
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
19-Oxoandrost-4-ene-3,17-dione	HMDB Metabolites of Enzymes	1.0	null
Toxic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
NCOR-22424771-293T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.864527
diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.266877
POLR2A_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.865974
BRD-K67750179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27607
BRD-K25485483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86268
Perturb_12503_KD_ESR1_ERP130561	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.76868
Stat5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.2805
GTEX-WH7G-0426-SM-3NMBJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53718
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.8652
polymorphism	GeneRIF Biological Term Annotations	1.0	null
BRD-K30589514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32217
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.919865
15297395-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Right_Atrium	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.19424
BRD-K49409947	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05614
endothelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.488276
BRD-K27973265	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55268
comprehensive	GeneRIF Biological Term Annotations	1.0	null
NSD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0086
GTEX-RUSQ-0426-SM-47JWR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01825
CXCR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75403
BRD-K47030799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38757
THOC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.73556
periventricular stratum of PO1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1911
BRD-K64800655_HY-11001_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.424
uteroplacental	GeneRIF Biological Term Annotations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5075-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K18462967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09672
RCOR1	ENCODE Transcription Factor Targets	1.0	null
GTEX-Q2AG-0526-SM-2S1PW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05752
Cytochrome P450 - arranged by substrate type	Reactome Pathways 2024	1.0	null
GSE158834_10_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CA3 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.49368
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.40624
BRD-K22380647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32548
G122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05311
emerging	GeneRIF Biological Term Annotations	1.0	null
Subparafascicular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04782
retinal vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.118463
Cholestasis	CTD Gene-Disease Associations	1.0	1.38584
agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.179802
GTEX-OIZH-0326-SM-2HMKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01836
lateral group of nuclei, left, dorsal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.43116
496100594_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40469
PMC5629025-elife-27159-fig1-data1.xlsx-Direct_AR_target_genes-Control_only_genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5515741-medi-96-e7264-s001.xlsx-up-regulated_DEGs-SIM2_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
MED6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42717
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.980063
BRD-K34024207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07127
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73S-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
quipazine-5887	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y5-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-96-A4JL-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z6-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ACTMAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15255
caucasian	GeneRIF Biological Term Annotations	1.0	null
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
BRD-K15768601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32637
microvessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.612555
renal	GAD High Level Gene-Disease Associations	1.0	0.295739
Efflux pump complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.51
affect	GeneRIF Biological Term Annotations	1.0	null
GTEX-OHPK-0326-SM-2HMJO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919526
BRD-K16715205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69469
arachidonate	GeneRIF Biological Term Annotations	1.0	null
promote	GeneRIF Biological Term Annotations	1.0	null
BRD-K57244822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27541
CRCGN009_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92393
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.21173
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.883436
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7406-11A-01R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Vascular Inflammations	DisGeNET Gene-Phenotype Associations	1.0	null
r8 part of linear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42435
CSTF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69405
Lipid storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.529
BRD-K76461283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8204
layer III of piriform cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.40866
BRD-K81439435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65161
Alcoholic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.021
BRD-A19500257_geldanamycin_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K14707716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89292
intrinsic component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.32345
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6697777__F7	PFOCR Pathway Figure Associations 2024	1.0	null
HCC827	CCLE Cell Line Gene CNV Profiles	1.0	1.32848
CORL105	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4596
19658189-TableS5	GeneSigDB Published Gene Signatures	1.0	null
A388	COSMIC Cell Line Gene Mutation Profiles	1.0	null
metastasis	GeneRIF Biological Term Annotations	1.0	null
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.66839
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SRY	ChEA Transcription Factor Targets	1.0	null
outer CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19136
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-2666-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1395	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.795216
GSE125014_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3473-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Heart - Atrial Appendage	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.67937
spleen_3a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.16375
cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.212945
BRD-K60509482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9509
Metabolism of lipids	Reactome Pathways 2024	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A3WU-01B-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Anterolateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2711
atropine-2761	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29A-06A-12R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058331
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K36120694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60081
coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.452962
BRD-K71345532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37005
DOXORUBICIN HYDROCHLORIDE	DGIdb Drug Targets 2026	1.0	0.106289
PMC9169777-pnas.2120787119.sd07.xlsx-Sheet1-Dataset_S7_Significantly_differentially_expressed_genes_between_G2_and_GATA3_WT_T-ALL_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)	Reactome Pathways 2014	1.0	null
BDH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00418937
diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.247837
eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044521
Chloroplast thylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.518
Retinal vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.235
MPP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17695
GTEX-XBEC-1226-SM-4AT65	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97428
HCT-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K36725646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30201
MYH9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30811
GSE178532_2_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
estradiol_mus musculus_gpl4134_gse23241	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PWN1-2426-SM-48TDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01684
ATP5F1E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20376
BRD-K54260552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29656
5-hydroxythalidomide	CTD Gene-Chemical Interactions	1.0	null
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.667309
approaches	GeneRIF Biological Term Annotations	1.0	null
GSE169356_2_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_10_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K33236055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24755
Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)	Reactome Pathways 2014	1.0	null
BRD-K77273085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11041
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.28827
GTEX-WFG7-0726-SM-3GIKO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88095
adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056302
GSE207302,GSE207303_0_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Paraventricular hypothalamic nucleus, parvicellular division, anterior parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50596
GTEX-U4B1-0226-SM-4DXU8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95126
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.943549
TMEM238	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70379
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22392
H2BC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02193
PMC7020766__F3	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-X4XY-0526-SM-46MW1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00548
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC1557825__F4	PFOCR Pathway Figure Associations 2024	1.0	null
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S5-Table_S5_The_result_of_MR_analysis_and_sensitivity_analysis_for_FVC_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
DNAJC19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09771
LCMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91339
PICALM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82687
HDAC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74847
Brain endothelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.987
H3K9me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CROCC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85634
XBP1_OE_GDS2861_60_human_MCF7 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
respiratory epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.393819
cefaclor-6622	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Vitamin D-dependent rickets type 1B	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.31006
dental caries	GWASdb SNP-Disease Associations	1.0	0.658446
BRD-K87909389_alvocidib_MDAMB231_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K73795883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62468
H3K27me3_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
renal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.629101
BRD-K93484038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58486
functionally	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
site	GeneRIF Biological Term Annotations	1.0	null
leiomyosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.298883
BRD-K32495578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27393
KDM3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00598369
Brain Lower Grade Glioma_LGG_TCGA-HT-7485-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pancuronium bromide-7329	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A5ZF-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRKAB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00507593
transverse	GeneRIF Biological Term Annotations	1.0	null
496100580_PCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.19601
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2787
sarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.100184
E2F4	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
rostral subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.55761
BRD-K36168475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.155
Cytochrome P450, E-class, group I	InterPro Predicted Protein Domain Annotations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KQ-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
linoleic acid epoxygenase activity	GO Molecular Function Annotations 2025	1.0	null
BRD-K83049611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09591
CDK4_knockdown_133_GSE31534	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.11356
GTEX-PVOW-0426-SM-2XCF8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49468
18387200-Genes	GeneSigDB Published Gene Signatures	1.0	null
BRD-K44204252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18081
ZNF277	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18403
cyp2c9	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K79090631_CGP-60474_HCC515_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
aorta endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.209633
GTEX-VUSG-2426-SM-4KKZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01295
GSE158834_2_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KINGS-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.58025
inferior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17014
cultured	GeneRIF Biological Term Annotations	1.0	null
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15399
MED9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58361
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3264
HCST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00654516
Obstructive lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
cSARS Bat SRBD_54Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.70966
PMC5795782-supp_gad.302646.117_Supplemental_Table_S1.xlsx-Table_S1_1-Supplemental_Table_S1_1_Genes_significantly_downregulated_by_ARID5B_knockdown_ARID5B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_12hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
RUNX2	ChEA Transcription Factor Targets	1.0	null
nizatidine-6305	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
P63_DEPLETION_GDS2534_63_human_ME180 cervical carcinoma cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
linoleic acid metabolic process	GO Biological Process Annotations 2023	1.0	null
BRD-K79730625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14243
BRD-K91003483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0547
BRD-K94132559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08386
OVCA 429	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.70706
Atoh1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	44.9234
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.13191
physostigmine-2768	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K43992442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25634
glucose	GeneRIF Biological Term Annotations	1.0	null
Stat2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	60.3433
HUH1	CCLE Cell Line Gene Expression Profiles	1.0	1.39104
BRD-K88642841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35818
GSE155031_6_v_0_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
Corpus callosum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7646
GSE145249_0_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-VUSG-0726-SM-3GIK1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00243
cyp2s1	GeneRIF Biological Term Annotations	1.0	null
respiratory	GeneRIF Biological Term Annotations	1.0	null
cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.072072
DKK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00667931
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.416521
Dilated cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
C1orf50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03915
Hyperemia	DisGeNET Gene-Disease Associations	1.0	null
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.981764
H3K4me1_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCUR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00432643
ventral part of PHyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33507
outer CP in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26384
GTEX-WYVS-2526-SM-3NMAT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
SNU-719	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K71755056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77228
GSE115364_0_v_1_idh3a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.711
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6943-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CA1 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.948441
Rectum adenocarcinoma_READ_TCGA-G5-6572-02A-12R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K40826084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03059
B9D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03284
Muscle - Skeletal	GTEx Tissue Gene Expression Profiles 2023	1.0	1.4895
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12314
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE158834_12_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
pretectal region	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.86539
longterm	GeneRIF Biological Term Annotations	1.0	null
GTEX-R55C-1826-SM-3GADI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01529
dorsal cortical nucleus of inferior colliculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21959
Cytochrome P450, E-class, group I, CYP2J-like	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K27265817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46511
E2F6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
established	GeneRIF Biological Term Annotations	1.0	null
CTCFL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.74749
GTEX-PX3G-0826-SM-48TZS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13752
Intrinsic Asthma	DisGeNET Gene-Disease Associations	1.0	null
laterodorsal subdivision of area 8	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01554
BRD-K73395020_ARP 101_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
carbohydrate metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.356341
memantine-4017	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
limitans nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.91484
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5654
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KLHDC7B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00527736
Lung adenocarcinoma_LUAD_TCGA-75-5146-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
crohns	GeneRIF Biological Term Annotations	1.0	null
GTEX-QV44-0526-SM-2S1RE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25632
lateral tuberal nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.52904
telencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
DMS53	CCLE Cell Line Gene CNV Profiles	1.0	1.67503
GSE158182_5_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.01477
lung endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.400628
PRKACB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29765
GTEX-U412-0008-SM-4DXTE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01157
Glomerulonephritis, IGA	HuGE Navigator Gene-Phenotype Associations	1.0	null
Cerebral hemisphere	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZNF862	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.118
Left ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.308
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M5-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STAT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00583564
BRD-K37722313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07948
nucleotide	GeneRIF Biological Term Annotations	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2838-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCE-4	COSMIC Cell Line Gene CNV Profiles	1.0	2.12225
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.665995
PMC11813851-12672_2025_1910_MOESM3_ESM.xlsx-Sheet1-Table_S2_Results_of_two-sample_drug-target_MR_analyses_for_pancreatic_cancer_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K11631946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05214
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.883865
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.12697
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4968-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TSHZ3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83693
BRD-K72894736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06233
18757322-TableS1	GeneSigDB Published Gene Signatures	1.0	null
vesicle	GO Cellular Component Annotations 2015	1.0	null
BRD-K93197397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36903
han	GeneRIF Biological Term Annotations	1.0	null
malignant	GeneRIF Biological Term Annotations	1.0	null
BRD-K44935022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50913
HNF1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8083
K562	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.37079
Umbilical vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.91
HSF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27201
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PAOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19796
BRD-K64264263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46878
BRD-K92457070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08448
GTEX-VJYA-1326-SM-3GIJC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.20111
Microvascular endothelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.078
worse	GeneRIF Biological Term Annotations	1.0	null
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.979378
GSE238116_1_v_0_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
amitriptyline-1701	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HES3_KD_GSE64449_187_mouse_Min6	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
MTMR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78316
transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.114203
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
STAT6_01_50	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.96402
PMC11111877-41598_2024_62256_MOESM7_ESM.xlsx-Table_S1-Supplementary_Table_S1_The_intersect_genes_of_AR_and_RNA_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cause	GeneRIF Biological Term Annotations	1.0	null
Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)	Reactome Pathways 2014	1.0	null
PANC1	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.997005
BRD-K00685640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36721
GSE158834_10_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Renal hypomagnesemia 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Ovary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.659756
Perturb_2491_Mut_ESR1_SRP254635	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
astrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.746277
Astemizole	HMDB Metabolites of Enzymes	1.0	null
BRD-K43389698_BMS-387032_HME1_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZC3H14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33036
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
HPAEC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.207
GSE135030_3_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.80388
LTBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28221
EMP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00585037
arcaine-3349	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7147-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ANKRD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34717
ovary	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.294939
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Vagina	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.532783
BRD-K05975035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67084
Primary somatosensory area, mouth, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92352
Head and Neck squamous cell carcinoma_HNSC_TCGA-UP-A6WW-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE183327,GSE183328_1_v_0_ddit3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.871948
Lung squamous cell carcinoma_LUSC_TCGA-43-3920-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100352_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06965
normal variation	GAD Gene-Disease Associations	1.0	null
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	49.7697
BRD-K62620616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77739
arachidonic	GeneRIF Biological Term Annotations	1.0	null
BRD-K54107674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15348
Ischemic Stroke	DisGeNET Gene-Disease Associations	1.0	null
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.93549
BRD-K90821428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52968
12(13)-EpOME	MW Enzyme Metabolite Associations	1.0	null
GTEX-X4XX-0011-R5A-SM-46MWN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871097
basal ventral medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.7309
Respiratory failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.16
BRD-K28296557_Akt inhibitor IV_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ARMCX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51071
GSE158182_4_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Arrhythmias, Cardiac	CTD Gene-Disease Associations	1.0	1.21011
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K64553072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74608
Testosterone	HMDB Metabolites of Enzymes	1.0	null
history	GeneRIF Biological Term Annotations	1.0	null
Perturb_11361_KD_METTL3_SRP292229	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.26365
H3K9ac_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.406361
making	GeneRIF Biological Term Annotations	1.0	null
unsaturated fatty acid metabolic process	GO Biological Process Annotations 2025	1.0	null
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X261-0926-SM-3NMCY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14683
vascular smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.673728
hsa-miR-4303	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
G112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.51112
Chorioallantois	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.033
BRD-K65945126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2264
Brain microvascular endothelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.958
Foxo3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.9498
TPR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00507336
Vascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.685
Renal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.256
pre-eclampsia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.325
infarction	GeneRIF Biological Term Annotations	1.0	null
SOD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74504
smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.710909
STAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22346
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K04695993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19063
GSE242083,GSE242098_2_v_0_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PDCD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36035
rolipram-5330	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	GO Molecular Function Annotations 2025	1.0	null
ACD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7402
Fetalliver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.26617
MG63	DepMap CRISPR Gene Dependency	1.0	3.91594
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.35633
BRD-K28472865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86154
features	GeneRIF Biological Term Annotations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6369-01A-21R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-P4QS-0226-SM-3NB1U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05251
Prostate adenocarcinoma_PRAD_TCGA-HC-7080-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KNS-81-FD	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K13390322_AT-7519_SKBR3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE164874_5_v_6_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
periventricular stratum of RtC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45479
Congenital Abnormalities	CTD Gene-Disease Associations	1.0	1.05648
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2407
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
caudal (posterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.2028
exogenous drug catabolic process	GO Biological Process Annotations 2015	1.0	null
ING5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85969
BRD-K26603007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17559
immune	GAD High Level Gene-Disease Associations	1.0	0.295739
GTEX-S7SE-0226-SM-2XCD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.919245
lateral group of nuclei, right, ventral division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.907037
paraventricular nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41313
H3K9ac_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE164874_5_v_13_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
lateral habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.31892
alfadolone-6506	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE125862_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
pramocaine-3811	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pain	CTD Gene-Disease Associations	1.0	1.01814
BRD-K37595074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23091
Glutathione	CTD Gene-Chemical Interactions	1.0	null
kidney failure, chronic	GAD Gene-Disease Associations	1.0	null
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.4128
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.0168
BRD-K04791118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86172
ion binding	GO Molecular Function Annotations 2015	1.0	null
CD177	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0052903
KYAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30474
arteriole	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.30883
GTEX-U4B1-0326-SM-3DB8K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.912582
BRD-K96144282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14645
anterior (rostral) cingulate (medial prefrontal) cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.930765
estradiol_homo sapiens_gpl14550_gse35034	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
zona glomerulosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.23604
BRD-K03506285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2716
GTEX-RM2N-1926-SM-48FCU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961636
oxidation-reduction process	GO Biological Process Annotations 2015	1.0	null
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
emboliform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.35743
CNOT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20986
MAP1S	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64147
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.4167
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
vascular tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.144735
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.52903
Vascular smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.732
Acute Myeloid Leukemia_LAML_TCGA-AB-2978-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.843881
GTEX-SNMC-0826-SM-4DM66	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90204
BTN2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28454
ATP5PB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82158
ethisterone-3783	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
uptake	GeneRIF Biological Term Annotations	1.0	null
Uterine Cervical Neoplasms	CTD Gene-Disease Associations	1.0	1.26175
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.19544
BRD-K46701848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0451
CEMIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81972
HNF4A	ChEA Transcription Factor Targets	1.0	null
CRO-AP3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Anteromedial visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27676
CRCGN013_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10195
Coronary Arteriosclerosis	DisGeNET Gene-Disease Associations	1.0	null
BRD-K18768614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01536
Pulmonary hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.259
ligandbinding	GeneRIF Biological Term Annotations	1.0	null
Pulmonary embolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.554
PMC10335698-pone.0285806.s007.xlsx-DMKN-shRNA_KD_Vs_ShSrc-Unnamed_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.92091
NPM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.88296
GBP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00610247
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K33283629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08487
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Transcription export complex 2	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.522
H3K4me1_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KMS12BM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3959
CHP212	CCLE Cell Line Gene CNV Profiles	-1.0	-2.79183
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
GEM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00549617
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6936-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-98-A538-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K73497584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75862
interpreted	GeneRIF Biological Term Annotations	1.0	null
GTEX-SUCS-0326-SM-32PLL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27257
H3K9me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
fatty acid metabolic process	GO Biological Process Annotations 2025	1.0	null
NADP	HMDB Metabolites of Enzymes	1.0	null
GSE248887_0_v_1_dkk1_human	RummaGEO Gene Perturbation Signatures	1.0	null
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26298
BRD-K86587289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6487
PAX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.066
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.226
myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.064873
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29Q-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-V955-0726-SM-3GAFG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00961
BRD-K48861177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57037
GSE164874_5_v_12_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hepatoma HLE cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.752
GTEX-XQ8I-0526-SM-4BOPS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859381
GSE226584,GSE226589_1_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U3ZH-0326-SM-3DB7A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20439
iron ion binding	GO Molecular Function Annotations 2015	1.0	null
Renal tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.663
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Cardia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.897
PMC7927818-AAC.01755-20-s0002.xlsx-Supplemental_Table_1-Supplemental_Table_1_List_of_significantly_altered_genes_in_MDMs_differentiated_in_the_presence_of_PrEP_FTC_v_No_Drug_TDF_v_No_Drug_FTC_v_TDF_SRY	Rummagene Transcription Factor Associations 2026	1.0	null
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.65654
NCI-H460	GDSC Cell Line Gene Expression Profiles	-1.0	-1.48688
EHHADH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00899599
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
preeclampsia	GeneRIF Biological Term Annotations	1.0	null
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07464
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.042226
NR6A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-5.11902
BRD-K77987907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58976
GTEX-U4B1-1126-SM-4DXV3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979429
PMC11953390-41598_2025_94761_MOESM1_ESM.xlsx-Table_S3-Table_S3_The_result_of_MR_analysis_and_sensitivity_analysis_for_CKD_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28839
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.0498
cyp	GeneRIF Biological Term Annotations	1.0	null
ALDH18A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7054
Primary somatosensory area, unassigned, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.21548
CRCGN016_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22376
Estradiol	HMDB Metabolites of Enzymes	1.0	null
GSE102132_2_v_1_irf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
monocarboxylic acid metabolic process	GO Biological Process Annotations 2023	1.0	null
Sarcoma_SARC_TCGA-DX-A6BE-01A-41R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X3Y1-0426-SM-3P5Z4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13055
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.41667
GTEX-QDVJ-0005-SM-2TC5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
occipital pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.71566
modes	GeneRIF Biological Term Annotations	1.0	null
spleen_3d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.2461
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_13_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
DLG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00468002
long-chain fatty acid metabolic process	GO Biological Process Annotations 2025	1.0	null
MAP2K2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98936
astroglial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.739266
mantle zone of m1AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18735
ESRRG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00638875
BRD-K24284160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09553
Aortic smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.903
Phase I - Functionalization of compounds	Reactome Pathways 2024	1.0	null
BRD-K58194737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76103
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BLCAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8817
pulmonary	GeneRIF Biological Term Annotations	1.0	null
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	1.0	3.16647
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q734-1626-SM-48U1B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
SLC43A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00507091
EBASTINE	DGIdb Drug Targets 2026	1.0	4.411
LRRC8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38214
GTEX-WYBS-1226-SM-3NM9N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6063
H3K4me1_Peripheral Blood Mononuclear Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PARP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94913
nephrotoxicity	GeneRIF Biological Term Annotations	1.0	null
Liver cirrhosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.194
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Arachidonic acid	HMDB Metabolites of Enzymes	1.0	null
reticular nucleus of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.835085
SOX2-21211035-LN229-GBM	ChEA Transcription Factor Targets 2022	1.0	null
GSE126463_0_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
rostral paraventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23707
hsa-miR-584	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
antibody	GeneRIF Biological Term Annotations	1.0	null
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5802
layer 4 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34849
Biological oxidations	Reactome Pathways 2014	1.0	null
BRD-K79090631_CGP-60474_HS578T_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
serine-type endopeptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.47
GSE147366_3_v_5_med13_human	RummaGEO Gene Perturbation Signatures	1.0	null
MANEA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62891
16166195-TableS1b	GeneSigDB Published Gene Signatures	1.0	null
Bradycardia	CTD Gene-Disease Associations	1.0	1.13313
BRD-K68395284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07157
BRD-K07565511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65151
UVSSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07627
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.983112
contribution	GeneRIF Biological Term Annotations	1.0	null
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.292
monocarboxylic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
17389037-Tab5	GeneSigDB Published Gene Signatures	1.0	null
GTEX-U3ZN-1026-SM-4DXTC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.969339
disulfiram-6210	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01795
arachidonate 11,12-epoxygenase activity	GO Molecular Function Annotations 2025	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7482-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LU165	DepMap CRISPR Gene Dependency	1.0	9.55356
AR-21909140-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
mantle zone of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.49768
MKNK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21778
extracellular organelle	GO Cellular Component Annotations 2015	1.0	null
HLA-DRA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00601144
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of LPrP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21405
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ERRFI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33874
GSE158458_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ANHYDROUS TACROLIMUS	DGIdb Drug Targets 2026	1.0	0.569161
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3324-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE191021_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE143944_2_v_3_ribociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RU1J-1026-SM-46MUR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
pulmonary hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.820847
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.355
GTEX-WH7G-0326-SM-3NMBH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14819
acts	GeneRIF Biological Term Annotations	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NA-A4QW-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
renal tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.918633
BRD-K90879242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28522
KPNYN	CCLE Cell Line Gene CNV Profiles	-1.0	-2.44116
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.834
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.248361
myoblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.404797
endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.00283
TCF4-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064873
BRD-K08881846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26441
Bronchial disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.351
PMC7488531-13287_2020_1914_MOESM10_ESM.xlsx-HNF4A_regulated_DEGs_750-Unnamed_1_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
vascular	GeneRIF Biological Term Annotations	1.0	null
BRD-K45097650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17075
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K91820608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14828
Prostate adenocarcinoma_PRAD_TCGA-HC-7738-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2995-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BCL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77914
Inflammation	CTD Gene-Disease Associations	1.0	1.58678
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ventral paracommissural tectal nucleus, m1 part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31705
acid	GeneRIF Biological Term Annotations	1.0	null
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.39485
striatum_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.28921
sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062738
medial superior olive	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.98245
TMEM234	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94809
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06706
organelle part	GO Cellular Component Annotations 2015	1.0	null
males	GeneRIF Biological Term Annotations	1.0	null
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.67821
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65J-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H522	GDSC Cell Line Gene Expression Profiles	-1.0	-1.5078
BRD-K61772027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13612
BRD-K15567136_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.269701
GSE228017_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_3927_KO_KMT2A_SRP277158	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SN-01A-12R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNASEK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44169
BRD-K80098154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15999
BRD-K19220233_JNK-9L_HS578T_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.266
Rarb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	73.2439
BRD-K46949676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53402
FBXL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.04517
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	1.10412
12917207-TableS5	GeneSigDB Published Gene Signatures	1.0	null
Paraventricular hypothalamic nucleus, descending division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00457
GSE242199_6_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K43389698_BMS-387032_BT20_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
upper limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.80979
BRD-K13390322_AT-7519_HS578T_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
acute	GeneRIF Biological Term Annotations	1.0	null
medial preoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.989782
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
basis	GeneRIF Biological Term Annotations	1.0	null
BRD-K87909389_alvocidib_MDAMB231_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QVUS-0426-SM-48FE3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.997891
ORC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67655
Lung adenocarcinoma_LUAD_TCGA-55-8514-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC3960207-oncotarget-05-0264-s002.xls-rank_down_foxp3_symb-Supplementary_Table_2_Genes_significantly_differentially_expressed_between_the_SK-MEL-28-FOXP3_and_SK-MEL-28-EV_clones_FOXP3	Rummagene Transcription Factor Associations 2026	1.0	null
Secondary motor area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5449
Diabetes	DisGeNET Gene-Disease Associations	1.0	null
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.43
layer 1 of VPrP cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03276
Gata3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.0407
BRD-K40985311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66409
17724462-TableS1	GeneSigDB Published Gene Signatures	1.0	null
vascular smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.931908
GTEX-T6MN-0926-SM-32PLX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7046
GTEX-OOBJ-0326-SM-33HBO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39495
RVH421	DepMap CRISPR Gene Dependency	1.0	2.38183
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.214
Bladder Urothelial Carcinoma_BLCA_TCGA-HQ-A2OE-01A-11R-A206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.2145
artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.4888
BRD-K44177822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00913
GSE168401_1_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7238-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AG-013608-6440	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cardiac muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.993249
BRD-K20028734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07684
stratum pyramidale of caudal CA3	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.985852
systolic	GeneRIF Biological Term Annotations	1.0	null
GTEX-UPK5-1426-SM-4JBHH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15368
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of p3ZL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29009
DOV13	CCLE Cell Line Gene CNV Profiles	1.0	1.60323
GTEX-RN64-1826-SM-48FDV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04147
H3K4me1_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
adrenal gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.079379
mantle zone of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08237
Anteromedial visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37693
GSE242083,GSE242098_3_v_1_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Huntington's Disease_Brain_GSE3621	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.89468
BRD-K06611347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46203
AMOT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68714
Masoprocol	HMDB Metabolites of Enzymes	1.0	null
pi3kakt	GeneRIF Biological Term Annotations	1.0	null
SARS-CoV MA15_Day2-PFU-10^4_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.66515
BRD-K64904523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23726
Main olfactory bulb, inner plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02087
EMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0466
endoplasmic reticulum part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_AA_NP-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
flexible	GeneRIF Biological Term Annotations	1.0	null
GSE120216_3_v_0_cbfb_human	RummaGEO Gene Perturbation Signatures	1.0	null
PDIA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2039
ZFP69	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77277
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
aim	GeneRIF Biological Term Annotations	1.0	null
cardiomyocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.547326
BRD-K42367391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05776
gracile nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.30548
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
TDRD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14791
arachidonic acid metabolic process	GO Biological Process Annotations 2023	1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.394
4-hydroxy-2-nonenal	CTD Gene-Chemical Interactions	1.0	null
lines	GeneRIF Biological Term Annotations	1.0	null
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Ebf2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.6848
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18377
TAF1	ENCODE Transcription Factor Targets	1.0	null
Nr5a1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.6702
NDUFA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45084
NEPRO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1491
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21838
BRD-K37564297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.61815
GSE187006_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
epoxygenase P450 pathway	GO Biological Process Annotations 2025	1.0	null
BRD-K46291400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40917
myocardial infarction	GAD Gene-Disease Associations	1.0	null
NECTIN4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00618932
layer 5 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01011
cellular process	GO Biological Process Annotations 2015	1.0	null
ZNF441	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54866
PMC7441006-41388_2020_1389_MOESM2_ESM.xlsx-Supplementary_Table_1-Prostate-Specific_MYC_Overexpression_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-95-7947-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27ac_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.89471
H4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.71522
primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.834213
BRD-K78748401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28912
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S2-Table_S2_Full_result_of_MR_estimates_for_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.900939
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.743389
Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.36247
NCI-H727	GDSC Cell Line Gene Expression Profiles	-1.0	-1.48849
BRD-K63654001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12461
proton-transporting two-sector ATPase complex, proton-transporting domain	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.614
Perturb_14584_KD_ATF3_SRP237943	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
hypertension	GeneRIF Biological Term Annotations	1.0	null
outer plexiform zone in extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19581
GSE175787_11_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3853418-1756-8935-6-34-S3.pdf-18-CREB1_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
docking	GeneRIF Biological Term Annotations	1.0	null
GTEX-S7SF-0526-SM-3K2BC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11142
EM2	DepMap CRISPR Gene Dependency	1.0	5.58025
BRD-K56778317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8085
astroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.796041
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.52473
RH30	CCLE Cell Line Gene CNV Profiles	1.0	1.7517
tretinoin-384	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
calcineurin	GeneRIF Biological Term Annotations	1.0	null
BRD-K49029187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46699
C1orf210	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45569
IGF2BP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00649094
CRCGN008_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.09145
any	GeneRIF Biological Term Annotations	1.0	null
probe	GeneRIF Biological Term Annotations	1.0	null
PABIR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24214
BRD-K79732056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01515
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Cardiac muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.733
BRD-K17040651	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09717
Metabolic dysfunction-associated steatohepatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.073
7a-Hydroxytestosterone	HMDB Metabolites of Enzymes	1.0	null
PMC7617064-EMS151900-supplement-Extended_Data_Figure_7_Source_Data.xlsx-D23_RORC-Logfold_change_threshold_1_0_1_RORC	Rummagene Transcription Factor Associations 2026	1.0	null
ZBTB7B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00525902
PEX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50668
GTEX-U3ZN-1426-SM-3DB87	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04283
BRD-K72424071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0171
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.58964
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K13241788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.78019
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
GTEX-XXEK-1026-SM-4BRUW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19375
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K93159873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33043
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.58
Shox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.7454
heart	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.32596
BRD-K23203419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04904
ethaverine-6737	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
baec cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.720345
carboxylic acid metabolic process	GO Biological Process Annotations 2023	1.0	null
PMC2962793__F2	PFOCR Pathway Figure Associations 2023	1.0	null
stratum pyramidale of rostral CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0801
KPL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.924047
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Y-27632-948	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Nerve - Tibial	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.694855
BRD-K98272474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09914
BRD-K72661036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54594
GTEX-P4PQ-2626-SM-33HC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877544
BRD-M01343043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0353
loperamide-4672	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A89947015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01967
employed	GeneRIF Biological Term Annotations	1.0	null
Nr1h3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.1758
AR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48524
JR	DepMap CRISPR Gene Dependency	1.0	2.05658
ACOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52265
RFX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1394
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MS-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
element	GeneRIF Biological Term Annotations	1.0	null
GSE158834_2_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRO-AP2	GDSC Cell Line Gene Expression Profiles	-1.0	-2.08907
5,6-EpETrE	MW Enzyme Metabolite Associations	1.0	null
monocytic	GeneRIF Biological Term Annotations	1.0	null
examined	GeneRIF Biological Term Annotations	1.0	null
BRD-K74881104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07929
PMC5889290-koni-07-04-1412909-s001.xlsx-GSC-exo_vs_Fibro-exo_stat_sign-Gene_name_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-O5YV-0008-SM-4E3HP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.891028
GTEX-V955-0926-SM-4JBJ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.884087
PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_down-regulated_in_Myc_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K58863194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17695
BRD-K50162138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40834
Doxorubicin	CTD Gene-Chemical Interactions	1.0	null
alvespimycin-5573	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TEAD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4446
pulmonary artery endothelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.178846
PMC10810548-pone.0289518.s002.xlsx-SOM_w_identifiers-target_gene_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
evidence	GeneRIF Biological Term Annotations	1.0	null
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30955
Arteriosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.807
TGFB_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
BRD-K12862541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30504
BRD-K59657378	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03186
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.804
PMC7773148__F1	PFOCR Pathway Figure Associations 2024	1.0	null
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.733912
HNRNPU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09935
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormality of the face	GWASdb SNP-Phenotype Associations	1.0	0.108447
Interstitial lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.149
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.41285
ondansetron-5796	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K93726930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10728
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5192-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K13390322_AT-7519_HS578T_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K92571446_WZ-3105_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CDC5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63376
H3K9ac_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
enzymes	GeneRIF Biological Term Annotations	1.0	null
PCK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05038
16151515-TableS4	GeneSigDB Published Gene Signatures	1.0	null
amygdaloid complex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.979731
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.59416
enzyme	GeneRIF Biological Term Annotations	1.0	null
abnormality of the oral cavity	GWASdb SNP-Phenotype Associations	1.0	0.154182
ligands	GeneRIF Biological Term Annotations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DM-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUP-HD1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-WYJK-1126-SM-3NM9Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27136
ABCD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00448513
DSH1	GDSC Cell Line Gene Expression Profiles	1.0	1.77059
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.19301
BRD-K96362535_DIHYDRO-beta-TUBAIC ACID_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SO-01B-31R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K36me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DYNC1LI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19688
BRD-K38273665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.35086
GSE114284_4_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SNOS-0526-SM-4DM54	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832857
Squamous Cell Carcinoma Of The Head And Neck	DisGeNET Gene-Disease Associations	1.0	null
H3K9me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K68968009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15093
TBC1D10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05571
BRD-K28079391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93525
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.981953
clioquinol-6461	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K97934318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43846
LP1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32355
TK-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0065
CADM1_KO_GDS2026_301_mouse_testis	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MP-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SC-58125-254	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SKIDA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02125
Ikzf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.6145
GSE158834_1_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Congestive heart failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.318
NANOG-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
METTL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98759
Kidney renal papillary cell carcinoma_KIRP_TCGA-WN-A9G9-01A-12R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07655
Initial collecting tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.554
BRD-K77713205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88383
lung	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.621831
Neurod2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	56.7998
GTEX-T5JW-1726-SM-3GADN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28903
BRD-K56661847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21977
BRD-K40248932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06001
FAM76B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43072
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.982706
GSE155031_6_v_3_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
ovambo	GeneRIF Biological Term Annotations	1.0	null
BRD-A18497530_EI-293_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NGFR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00506368
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
small intestine	HPA Tissue Gene Expression Profiles	1.0	1.04224
3-M syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.752884
NBN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06686
BRD-K96249452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74632
GTEX-WFG8-0626-SM-3GILJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62604
GTEX-S32W-2226-SM-2XCAY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951199
primary motor cortex (area M1, area 4)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.970506
chlorprothixene-5291	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
peripheral vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.318999
HCFC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81204
GSE226285_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
VSIG8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00401417
PPP1R8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23604
GTEX-XOT4-0426-SM-4B66T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88667
Perturb_13853_KO_RET_ERP126468	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K39016838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08432
PLXNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92823
Primary somatosensory area, trunk, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17251
calycanthine-5744	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
metaanalysis	GeneRIF Biological Term Annotations	1.0	null
YAPC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.17573
GSE142210_3_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K32423836	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08015
decreased	GeneRIF Biological Term Annotations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A870-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Dlx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	13.764
icSARS CoV_54Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.2363
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.843742
ISL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	12.8722
CXCR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00601059
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.34926
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.194
PMC7020766__F3	PFOCR Pathway Figure Associations 2023	1.0	null
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.6529
GTEX-WL46-0926-SM-3LK7T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33064
GTEX-U3ZN-0226-SM-3DB8D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24774
Hemorrhage	CTD Gene-Disease Associations	1.0	1.23169
orbital frontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.961868
BRD-K38574421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54573
seh	GeneRIF Biological Term Annotations	1.0	null
FEM1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62015
TBL1-22424771-293T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41492
STAT3	ENCODE Transcription Factor Targets	1.0	null
KYSE-410	GDSC Cell Line Gene Expression Profiles	1.0	1.53229
influences	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_Rectal Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me1_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC8844187-Table_2.xlsx-prostate-DLX1_DLX1	Rummagene Transcription Factor Associations 2026	1.0	null
nifedipine-335	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
rostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.28831
GATA3	JASPAR Predicted Transcription Factor Targets	1.0	null
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.983657
Aortic endothelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.407
transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.110865
BRD-K76068355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75896
TYK2_KD_GDS4754_158_human_JURKAT	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
regulation of blood circulation	GO Biological Process Annotations 2023	1.0	null
astroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.088143
Atrial fibrillation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.033
EOGT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44711
GSE253089_0_v_1_ephb2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF98	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2938
BRD-K72681425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14389
CRCGN008_HEPG2_24H:I03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0041
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_MCF10A.TP53.M_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.84925
humans	GeneRIF Biological Term Annotations	1.0	null
regulate	GeneRIF Biological Term Annotations	1.0	null
CRCGN008_HEPG2_24H:I02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.52195
PANX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56343
Brain Lower Grade Glioma_LGG_TCGA-FG-A711-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RWS6-0426-SM-47JXH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02448
DPYSL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00580535
regulation of heart contraction	GO Biological Process Annotations 2025	1.0	null
TEN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49707
8,9-EpETrE	MW Enzyme Metabolite Associations	1.0	null
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.06294
H1_Derived_Mesenchymal_Stem_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.08102
BRD-K55598155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47129
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
recognition	GeneRIF Biological Term Annotations	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
BRD-K78809123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36195
mice	GeneRIF Biological Term Annotations	1.0	null
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.097
BRD-K48593237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01735
Hemopericardium	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.303
CD8+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.62384
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.20527
primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.8951
Proteinuria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.125
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K94582731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39521
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Hmgn1_KO_GDS5010_406_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K4me3_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TJP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84426
AKT1_knockdown_135_GSE31534	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.35428
GSE164874_5_v_11_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PSD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93863
RAB25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65012
lateral group of nuclei, left, ventral division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.983097
SARS-BatSRBD_36Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.24853
butamben-5792	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUJ4-0626-SM-4BOOO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20786
COA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19431
TXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39814
Entorhinal area, lateral part, layer 2a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26648
Arachidonic acid metabolism	Reactome Pathways 2014	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3Z9-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal glucose homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.174879
GSE155031_6_v_2_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K30358777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06841
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
GTEX-WYJK-1026-SM-3NM8W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30025
CRCGN008_HEPG2_24H:J03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2816
ECHDC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74593
Secondary motor area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.28958
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
SNAI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8868
defect	GeneRIF Biological Term Annotations	1.0	null
GTEX-XPVG-0926-SM-4B651	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36079
AMIGO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00491572
BRD-K28467592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22477
BRD-K35429158	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99599
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.211
approach	GeneRIF Biological Term Annotations	1.0	null
BRD-K31354456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27999
extracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
Terfenadine	CTD Gene-Chemical Interactions	1.0	null
GTEX-OHPK-1826-SM-2YUMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
GTEX-OIZI-1126-SM-3NB1F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.94305
TRIL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02684
GTEX-U8XE-0626-SM-3DB8U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07778
PMC6225799-annrheumdis-2018-213524supp003.xlsx-Activated-state-LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ERGIC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36783
Anterolateral visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80282
DDX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86265
H3K4me3_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A5F2-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T5JC-0226-SM-32PMA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11396
PMC7523182-Table_2.XLSX-Lipid_metabolism_pathways-NR1H4_NR1H4	Rummagene Transcription Factor Associations 2026	1.0	null
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.445
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043111
hsa-miR-4261	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Postpiriform transition area, layers 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14686
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30955
sarcolemma	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.490944
prednicarbate-5119	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Glioma	DisGeNET Gene-Disease Associations	1.0	null
sin3a_22783022_mcf7_lof_human_gpl570_gds4388	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.147434
GTEX-X88G-0008-SM-47JWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-PLZ5-1126-SM-3P613	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907763
GSE148658_1_v_0_six6_human	RummaGEO Gene Perturbation Signatures	1.0	null
PHOX2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8945
TRIM28	ENCODE Transcription Factor Targets	1.0	null
ARNT_01_317	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-1.72786
dorsal thalamus_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.993952
Valproic acid	HMDB Metabolites of Enzymes	1.0	null
NDUFV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35629
PRELID3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69741
pedunculo(pontine) tegmental  nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00702
GTEX-OOBJ-0226-SM-2YUMM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24521
H3K4me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE238018_3_v_2_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216540_1_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
investigated	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
Atrophy	CTD Gene-Disease Associations	1.0	1.13109
GSE128844_0_v_1_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K39859838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15692
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AP-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Long QT Syndrome	CTD Gene-Disease Associations	1.0	1.14713
BRD-K62983405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.55573
Cortical collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.2
H3K4me3_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ID1_01_117	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.18657
CCDC92B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20991
BRD-K99545815_PF-562271_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K59930979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2919
correlated	GeneRIF Biological Term Annotations	1.0	null
16024625-SuppTable2a	GeneSigDB Published Gene Signatures	1.0	null
GTEX-N7MS-0826-SM-2HML4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58127
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2424
BRD-K79753227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22046
Vascular endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.877
MCFD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82258
background diabetic retinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.518034
xenobiotics	GeneRIF Biological Term Annotations	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LB-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF763	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32849
Tryptophan metabolism(Mus musculus)	WikiPathways Pathways 2014	1.0	null
heart_5b	HPA Tissue Sample Gene Expression Profiles	1.0	1.06441
PMC10709142-41556_2023_1281_MOESM2_ESM.xlsx-Supplementary_Table_1-CLUSTER_1_MAF_upregulated_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
IRF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2842
plumule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.075334
GSE147366_3_v_2_med13_human	RummaGEO Gene Perturbation Signatures	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2832-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cation binding	GO Molecular Function Annotations 2015	1.0	null
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.026895
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE227698_5_v_0_g0s2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Piriform area, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10343
Piriform area, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39185
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.913802
BRD-K64404450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23801
populations	GeneRIF Biological Term Annotations	1.0	null
HGC-27	GDSC Cell Line Gene Expression Profiles	-1.0	-1.42946
resistance	GeneRIF Biological Term Annotations	1.0	null
ATP6V1F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56232
hypoxia	GeneRIF Biological Term Annotations	1.0	null
BRD-K98510376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02263
H3K23me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-M7-A721-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.08
superficial stratum of ERCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08044
CA1 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.34042
dicloxacillin-6666	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
19-Hydroxytestosterone	HMDB Metabolites of Enzymes	1.0	null
BRD-K93044218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16988
PMC6932815-ppat.1007634.s015.xlsx-ST5_DGE_ELF1-R8AvIFN48-mock_lfc-ensembl_gene_id_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.20097
GSE207301,GSE207303_1_v_3_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE200099_3_v_1_honokiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Metyrapone	CTD Gene-Chemical Interactions	1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
inhibited	GeneRIF Biological Term Annotations	1.0	null
COL4A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8447
GSE161846,GSE161849_3_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Chronic obstructive pulmonary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
KMS11	CCLE Cell Line Gene CNV Profiles	1.0	1.85783
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
outer CP in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04198
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.321
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.916197
MPND	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25897
Pulmonary artery endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.985
ADAM15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23231
Prostate adenocarcinoma_PRAD_TCGA-XJ-A83G-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Renal Hypertension	DisGeNET Gene-Disease Associations	1.0	null
BRD-K71817857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10878
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K64824710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00735
BRD-K72414522_AZD-5438_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-U00779237_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GRPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51217
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AO-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediates	GeneRIF Biological Term Annotations	1.0	null
BRD-K38615104_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE195559_8_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.443
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45P-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Heart endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.819
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
amoxapine-1513	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
INF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.09865
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A69B-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CF-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158182_3_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
myoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.187229
PMC11976269-41375_2025_2519_MOESM3_ESM.xlsx-ChIP_GATA2_Cluster_A-GeneName_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
Forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
UCHL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5147
ZNF644	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39812
GTEX-S4P3-0226-SM-3K2BD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
IL17A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00595123
JVE253	DepMap CRISPR Gene Dependency	1.0	2.42473
BRD-K18294143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27382
BRD-K42976515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10359
nalidixic acid-2297	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intermediate stratum of m1AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31439
nfkappabdependent	GeneRIF Biological Term Annotations	1.0	null
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MTHFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22679
sidechain	GeneRIF Biological Term Annotations	1.0	null
CAL78	CCLE Cell Line Gene CNV Profiles	1.0	1.64423
GSE115542_2_v_0_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Seminal vesicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.984
produce	GeneRIF Biological Term Annotations	1.0	null
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K29331543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05355
pain agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.183541
triflusal-7451	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147366_1_v_2_med13_human	RummaGEO Gene Perturbation Signatures	1.0	null
VSX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31478
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A5PC-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
regulation of multicellular organismal process	GO Biological Process Annotations 2015	1.0	null
Ebolavirus(EBOV)_5day_PBMCs_17725815_GSE8317	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.18868
Abdominal aortic aneurysm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.28
km3	HPA Cell Line Gene Expression Profiles	-1.0	-1.05471
GTEX-XQ8I-0126-SM-4BOPL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10388
PMC9526348-12885_2022_10110_MOESM2_ESM.docx-0-NR1H2_NR1H2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
BL5039 (CHD9)	NURSA Protein Complexes	1.0	null
BRD-K47254434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08127
GTEX-V1D1-0526-SM-4JBGW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37049
NADP+	MW Enzyme Metabolite Associations	1.0	null
H3K27ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE155031_5_v_2_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAFG::NFE2L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.253
GTEX-T2IS-2026-SM-4DM6W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
BICR16	DepMap CRISPR Gene Dependency	1.0	3.27516
BRD-K51370144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92937
WBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.47311
H3K4me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-P4PQ-0326-SM-2HMJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04814
Bronchial smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.612
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
roles	GeneRIF Biological Term Annotations	1.0	null
express	GeneRIF Biological Term Annotations	1.0	null
UFM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82697
SKMEL2	BioGPS Cell Line Gene Expression Profiles	1.0	1.43209
carboxylic acid metabolic process	GO Biological Process Annotations 2025	1.0	null
SRRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68092
cytosol	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.446862
BRD-K07396550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00066
polyketide synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.164089
USF1_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K30145193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91546
15297395-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
GSE158834_11_v_8_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:N10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0203
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.42428
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
Skin	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FAAP24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45693
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
reposition	GeneRIF Biological Term Annotations	1.0	null
chorioallantois	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.24486
Sustentacular cell_Olfactory neuroepithelium_Human	CellMarker Gene-Cell Type Associations	1.0	null
GTEX-OHPK-0226-SM-3MJH6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874078
overall	GeneRIF Biological Term Annotations	1.0	null
Estrone	HMDB Metabolites of Enzymes	1.0	null
BRD-K16485616_S1122_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5174-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.114863
humanderived	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.516
Tcf21	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	42.867
PRMT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00384578
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SRSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45751
LEF1_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
assay	GeneRIF Biological Term Annotations	1.0	null
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31451
GTEX-U3ZN-0526-SM-4DXTH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.162117
common	GeneRIF Biological Term Annotations	1.0	null
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GroEL-GroES complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.172
Poisoning	CTD Gene-Disease Associations	1.0	1.76597
MDA MB435	BioGPS Cell Line Gene Expression Profiles	1.0	0.915343
KDM5C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00449771
BRD-K88313926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0829
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
OlfactoryBulb	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.0516
C2CD4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42274
NALM16	DepMap CRISPR Gene Dependency	1.0	2.44262
extracellular vesicular exosome	GO Cellular Component Annotations 2015	1.0	null
PL45	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53807
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02375
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6072
liver cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.080731
CRCGN017_MCF10A.WT.HP_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03119
Cytochrome P450, conserved site	InterPro Predicted Protein Domain Annotations	1.0	null
CRCGN017_MCF10A.TP53.M_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.9932
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0829
GTEX-XBEC-1526-SM-4AT68	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938145
Trolox C-6007	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WHPG-1026-SM-3NMBA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891952
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.70115
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
20548326-Table4	GeneSigDB Published Gene Signatures	1.0	null
GTEX-WFG8-2326-SM-3GILF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
Serotonergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.64
TNNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.13726
Retrosplenial area, lateral agranular part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.69196
BRD-A45889380_QUINACRINE HYDROCHLORIDE_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Defective MAOA causes Brunner syndrome (BRUNS)	Reactome Pathways 2014	1.0	null
BRD-K85235446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75106
CHAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03981
Lung adenocarcinoma_LUAD_TCGA-69-8254-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Piriform area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17466
present	GeneRIF Biological Term Annotations	1.0	null
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
increased heart left ventricle weight	MGI Mouse Phenotype Associations 2023	1.0	null
H4K20me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-RB-A7B8-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hypertension	CTD Gene-Disease Associations	1.0	1.23456
Sarcoma_SARC_TCGA-K1-A6RT-01A-32R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHGA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27552
External iliac artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.521
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.954907
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Cytochrome P450	InterPro Predicted Protein Domain Annotations	1.0	null
ACSL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3027
Bone remodeling disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.097
PMC7532671-thnov10p10957s2.xlsx-Table_S6A-Table_S6A_Differentially_expressed_genes_DEGs_in_DDX5_KD_versus_WT_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XBEC-0326-SM-4AT4M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890861
BRD-K90655269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81162
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.943549
KRAS.LUNG_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
Licofelone	DrugBank Drug Targets	1.0	null
Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)	Reactome Pathways 2014	1.0	null
GTEX-WH7G-0008-SM-4LVNM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841254
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0885
CHST7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98877
forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K36176133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78276
Prostate adenocarcinoma_PRAD_TCGA-KC-A7F5-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6192420__F2	PFOCR Pathway Figure Associations 2024	1.0	null
UBE4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.62127
PMC8582123-13073_2021_996_MOESM3_ESM.xlsx-PITX1-HIT_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
population	GeneRIF Biological Term Annotations	1.0	null
HTR3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.57928
BRD-K88746179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26663
Main olfactory bulb, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.76924
ebastine	CTD Gene-Chemical Interactions	1.0	null
MAX_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87909389_alvocidib_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Postpiriform transition area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18977
Nkx3-2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.539
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
basolateral nucleus (basal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.995426
BRD-K45589340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58848
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859814
mantle zone of m2AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.09288
Breast Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
RERFLCKJ	CCLE Cell Line Gene CNV Profiles	1.0	1.73466
5-lipoxygenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.551
SPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15878
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	65.8134
PL45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32666
GTEX-S7SF-1326-SM-4AD4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827885
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.84055
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K15515777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03457
MAX_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K10010115_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Peroxisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.936
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Posterior parietal association areas, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58636
Uterine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
Rickets	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.386
PLBD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65159
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
events	GeneRIF Biological Term Annotations	1.0	null
BRD-K76492619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37146
essential hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.297651
HCT15	BioGPS Cell Line Gene Expression Profiles	1.0	0.982142
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.426711
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
SET-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.96711
hsa-miR-4533	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
2-aminobenzenesulfonamide-3063	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
BRD-K46152990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02923
15297395-Table3	GeneSigDB Published Gene Signatures	1.0	null
flunisolide-3923	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
posteroventral (inferior) parietal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16708
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
GTEX-UTHO-1026-SM-3GAF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940496
GSE208350_0_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
organic acid metabolic process	GO Biological Process Annotations 2025	1.0	null
arsenic trioxide_homo sapiens_gpl201_gse48441	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
arachidonic acid 14,15-epoxygenase activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K55147629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72486
neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.077501
D-247MG	GDSC Cell Line Gene Expression Profiles	-1.0	-1.799
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.75552
Chronic kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.518
MARK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00502126
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.08747
BRD-K43389698_BMS-387032_HS578T_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Anteromedial visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70604
transactivation	GeneRIF Biological Term Annotations	1.0	null
rostral division of OFCi (area 11)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.87509
emboliform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.939404
PMC8582123-13073_2021_996_MOESM3_ESM.xlsx-IRF1-HIT_IRF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K64577478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32491
Pulmonary artery endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.011
PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_6_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTPBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31355
RNF169	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44182
H3K79me2_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE135030_11_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
paraventricular nucleus, cap part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63749
japanese	GeneRIF Biological Term Annotations	1.0	null
u698	HPA Cell Line Gene Expression Profiles	-1.0	-1.05471
BRD-K29003210_OSSK_647368_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.973893
thioridazine-4085	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-O5YV-0326-SM-2I5H2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38656
Androstenedione	HMDB Metabolites of Enzymes	1.0	null
inner CP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.50277
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8986528-41586_2022_4598_MOESM6_ESM.xlsx-Fig_4h-LAS1L_KD_upreg_AR	Rummagene Transcription Factor Associations 2026	1.0	null
furosemide-4503	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3NI-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OGA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61438
layer 4 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04139
NCIH2029	CCLE Cell Line Gene CNV Profiles	1.0	1.9545
g50t	GeneRIF Biological Term Annotations	1.0	null
outer SZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22306
PIK3C2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00651158
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
Aortic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.159
BRD-K49371609_528116.cdx_PL21_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
apoptosis	GeneRIF Biological Term Annotations	1.0	null
12917485-Table9	GeneSigDB Published Gene Signatures	1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Hepatoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.721
PMC10861538-41467_2024_45669_MOESM7_ESM.xlsx-Sheet1-Supplementary_Data_4_DEGs_upon_KD_of_EVT_TFs_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S4Z8-2026-SM-3K2A9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.843742
BRD-K28640166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05999
GTEX-WFG7-1526-SM-4LVMG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929299
nose	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.217554
bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.002908
BRD-K18523456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50213
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5191-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K49371609_528116.cdx_HA1E_24.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
arachidonate 14,15-epoxygenase activity	GO Molecular Function Annotations 2025	1.0	null
CRCGN015_MCF10A_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20637
BRD-K92022897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08321
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
bond	GeneRIF Biological Term Annotations	1.0	null
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7608-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GLA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92988
valproic acid_homo sapiens_gpl6883_gse26940	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
syrosingopine-2753	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K19220233_JNK-9L_MDAMB231_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
polymerase	GeneRIF Biological Term Annotations	1.0	null
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.844368
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_3hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
icosanoid metabolic process	GO Biological Process Annotations 2025	1.0	null
nucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.251114
family	GeneRIF Biological Term Annotations	1.0	null
CACYBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00997
HTRA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00447678
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
extracellular vesicle	GO Cellular Component Annotations 2015	1.0	null
GTEX-WZTO-1326-SM-3NM8X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962511
MFE280	CCLE Cell Line Gene CNV Profiles	1.0	1.40761
POMGNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91306
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
15297395-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
BRD-K16485616_mocetinostat_MCF7_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7101-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GGA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36724
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.920682
monocytes	GeneRIF Biological Term Annotations	1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.943
LARP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12734
AR	ChEA Transcription Factor Targets	1.0	null
GSE212312_2_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TMEM170B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83099
GTEX-TML8-1326-SM-4DXTO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88268
SCC-25	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.54096
Ketoconazole	CTD Gene-Chemical Interactions	1.0	null
contributes	GeneRIF Biological Term Annotations	1.0	null
JMY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57921
Lateral reticular nucleus, magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09336
chinese	GeneRIF Biological Term Annotations	1.0	null
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.603
CA4 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.865615
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN008_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60045
GSE153867_6_v_3_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-TMZS-0226-SM-3DB9N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03554
stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.083414
PMC10099894-NAN-49-0-s001.xlsx-GENIC_INTERSECT_VCF-MID_TBX1	Rummagene Transcription Factor Associations 2026	1.0	null
posterior part of anterior hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63899
BRD-K81206010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4517
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
atherosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.338707
PSS008	DepMap CRISPR Gene Dependency	1.0	7.12756
BRD-K87909389_alvocidib_MCF10A_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prostatic intraepithelial neoplasia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.741
BRD-K60024823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55674
variant	GeneRIF Biological Term Annotations	1.0	null
BRD-K18077898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02562
CRABP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91348
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Polyketide synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.287
KANSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01482
Agranular insular area, ventral part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15323
outer SZ in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.950674
Rectum adenocarcinoma_READ_TCGA-AH-6644-01A-21R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.569
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE134214_0_v_1_ell2_human	RummaGEO Gene Perturbation Signatures	1.0	null
layer 4 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17359
GTEX-X5EB-2426-SM-4E3HX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
did	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.880156
BRD-K13390322_AT-7519_HS578T_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Rivaroxaban	DrugBank Drug Targets	1.0	null
GTEX-WY7C-1126-SM-3NB3A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34019
H3K4me1_Skeletal Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MYBPC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00699728
ERLIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42523
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
interesting	GeneRIF Biological Term Annotations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-H4-A2HO-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4201688-12864_2014_6557_MOESM3_ESM.xlsx-Liver-PPAR_signaling_pathway_PPARA	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
upregulated	GeneRIF Biological Term Annotations	1.0	null
hydroflumethiazide-7019	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-REY6-0726-SM-2TF4M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
PMC11933697-41467_2025_58216_MOESM8_ESM.xlsx-SD6_ATF3_EV_NS1-SYMBOL_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
ventrolateral prefrontal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.961513
line	GeneRIF Biological Term Annotations	1.0	null
BRD-K01877528_TL_HRAS26_TYKNU_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Paraventricular hypothalamic nucleus, parvicellular division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61117
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.4639
cardiovascular	GAD High Level Gene-Disease Associations	1.0	0.329042
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7118
globose nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15516
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.26618
BRD-K84932026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30221
wt1_00000000_mouse_embryonic_fibroblast_mef_lof_mouse_gpl1261_gse15325	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.484862
C80	DepMap CRISPR Gene Dependency	1.0	6.8874
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K03733288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.33621
mantle zone of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10343
small	GeneRIF Biological Term Annotations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A9FF-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5452-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Heme	HMDB Metabolites of Enzymes	1.0	null
KYNU	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00855805
GSE158182_3_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Chaperonin ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.171
bone cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067081
BRD-K60806315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.57819
BRD-K40264914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38622
GTEX-WFON-0326-SM-3GIKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28515
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Main olfactory bulb, outer plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29131
pulmonary artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.63719
PMC8387919-mmc2.xlsx-ST2_NEUROG3_binding_sites-Unnamed_12_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
ergocalciferol-5346	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
trifluoperazine-7420	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K05286676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02288
GSE202434,GSE202438_9_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178714_6_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Coronary artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.849
Metapathway biotransformation(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
Arterial endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.773
intermediate stratum of DgSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00691
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.53
BRD-K79090631_CGP-60474_MCF10A_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5492-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ROBO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00601137
GSE156454_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
azathioprine-4667	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JHH2	CCLE Cell Line Gene CNV Profiles	1.0	3.19011
dorsal tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48391
Lung adenocarcinoma_LUAD_TCGA-78-8655-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-6146-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K24039194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20501
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A82F-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.308842
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.38008
SARS-CoV MA15_Day7_None_GSE49263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.23462
GTEX-QLQ7-1526-SM-2S1QA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
Acute Myeloid Leukemia_LAML_TCGA-AB-2868-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K52424224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38016
PMC11329632-41419_2024_6969_MOESM3_ESM.pdf-25-CREBL2_CREBL2	Rummagene Transcription Factor Associations 2026	1.0	null
long-chain fatty acid metabolic process	GO Biological Process Annotations 2015	1.0	null
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.880197
BRD-K43389675_DAUNORUBICIN_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZBTB25	Pathway Commons Protein-Protein Interactions	1.0	null
Dorsomedial nucleus of the hypothalamus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35464
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.45114
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0756
LOVO	CCLE Cell Line Gene Expression Profiles	1.0	1.98777
ZNF470	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28059
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.98248
UNC45A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64733
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-J2-A4AG-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
blood vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.47849
TBCEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.85879
typ3	GeneRIF Biological Term Annotations	1.0	null
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.35991
inner CP in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02375
MONOMAC1	DepMap CRISPR Gene Dependency	1.0	5.87678
cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.26778
haplotypes	GeneRIF Biological Term Annotations	1.0	null
Vitamin D-dependent rickets type 1A	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.019
GSE150134_1_v_0_fluorouracil_human	RummaGEO Drug Perturbation Signatures	1.0	null
TP63	JASPAR Predicted Transcription Factor Targets	1.0	null
PTTG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47744
aortic endothelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.662336
Acute myocardial infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.09
hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.18884
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DOV13	DepMap CRISPR Gene Dependency	1.0	2.37566
18698033-tableS1-ERBB2	GeneSigDB Published Gene Signatures	1.0	null
membrane	GO Cellular Component Annotations 2015	1.0	null
Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)	Reactome Pathways 2014	1.0	null
EYA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.99955
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HNF4A_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
MMAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22193
risk	GeneRIF Biological Term Annotations	1.0	null
Entorhinal area, lateral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21741
GTEX-XLM4-0008-SM-4AT4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
BRD-K92640680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0513
GSE74383_2_v_3_ror2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35544
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IF-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPRD1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33586
GTEX-OHPK-0008-SM-4E3JL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16822
BRD-K68544484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17953
OCLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44639
MZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.31989
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K79090631_CGP-60474_A549_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PPFIA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.42905
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_7260_KD_EP300_SRP193326	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11304
imipramine-1685	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07882
Organelle subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GTEX-S4Z8-0526-SM-4AD4T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858632
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
casecontrol	GeneRIF Biological Term Annotations	1.0	null
Stroke	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE216988,GSE216989_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.415
bilayers	GeneRIF Biological Term Annotations	1.0	null
layer III of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0818
provides	GeneRIF Biological Term Annotations	1.0	null
transition metal ion binding	GO Molecular Function Annotations 2015	1.0	null
GSE220097_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE164874_5_v_4_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Umbilical vein endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.587
icSARS-Cov_Day1_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.80993
heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.530381
perivascular astrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.224645
BRD-K87909389_alvocidib_MDAMB231_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
dentate (lateral) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.885266
Edema	CTD Gene-Disease Associations	1.0	1.82779
PELO	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0063747
BRD-K26459891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04526
GSE210101,GSE210114_11_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	GO Molecular Function Annotations 2023	1.0	null
BRD-A86977540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98179
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5587-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K49999779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34853
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MELHO	DepMap CRISPR Gene Dependency	1.0	3.56609
rt4	HPA Cell Line Gene Expression Profiles	1.0	1.89116
SNU283	CCLE Cell Line Gene Expression Profiles	1.0	1.76241
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7252-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K43889095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20292
BRD-K28108927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45809
H3K9ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
variation	GeneRIF Biological Term Annotations	1.0	null
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.27182
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6617
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4824-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K44403120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44175
Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)	Reactome Pathways 2014	1.0	null
GSE213650_3_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
hep3b2.17	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.776
Phase 1 - Functionalization of compounds	Reactome Pathways 2014	1.0	null
PMC12478325-12672_2025_3468_MOESM1_ESM.xlsx-Table_S9-Table_S9_Results_of_MR_analysis_between_druggable_genes_eQTLs_and_CrNEN_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Hydrogen sulfide	HMDB Metabolites of Enzymes	1.0	null
H3K27me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WRHU-1026-SM-4E3ID	GTEx Tissue Sample Gene Expression Profiles	1.0	2.26901
BLVRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23234
phenazopyridine-2537	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.10914
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32968
Atherosclerosis	HuGE Navigator Gene-Phenotype Associations	1.0	null
GTEX-U8XE-1126-SM-3DB8W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90412
H3K4me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
COLO-783	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SW1573	GDSC Cell Line Gene Expression Profiles	-1.0	-1.96837
Coma	CTD Gene-Disease Associations	1.0	1.15831
FMNL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54095
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01223
GSE153871_0_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10175786-Table4.XLSX-Sheet_1-GSE9750_AND_GSE63514_NOT_GSE7410_NOT_Ferrotosis_genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
endothelial	GeneRIF Biological Term Annotations	1.0	null
BRD-K13390322_AT-7519_BT20_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
cyp2c8	GeneRIF Biological Term Annotations	1.0	null
had	GeneRIF Biological Term Annotations	1.0	null
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
oculomotor nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.836527
PMC6932815-ppat.1007634.s014.xlsx-ST4_DGE_ELF1-R8AvIFN6-mock_lfc2-ensembl_gene_id_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
age	GeneRIF Biological Term Annotations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3329-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Entorhinal area, lateral part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48746
GTEX-R45C-0926-SM-3GAD4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879561
abnormality of the endocrine system	GWASdb SNP-Phenotype Associations	1.0	0.066133
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE114284_4_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.261
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
pulmonary artery endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.16079
TOP3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6302
epoxygenase P450 pathway	GO Biological Process Annotations 2023	1.0	null
14,15-Ep-11-HETrE	MW Enzyme Metabolite Associations	1.0	null
BRD-K53094498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17239
GTEX-Q2AH-0526-SM-2I3ED	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895204
BRD-K56426074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11095
Brain Lower Grade Glioma_LGG_TCGA-E1-5303-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K94518115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28454
linoleic acid metabolic process	GO Biological Process Annotations 2025	1.0	null
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-LEF1_UP_V1_DN-Gene_name_LEF1	Rummagene Transcription Factor Associations 2026	1.0	null
abnormality of head or neck	GWASdb SNP-Phenotype Associations	1.0	0.090377
H3K9ac_Peripheral Blood Mononuclear Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
left	GeneRIF Biological Term Annotations	1.0	null
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.087
GTEX-PWOO-2226-SM-2S1P1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
GSE195568_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7250-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
15H-11,12-EETA	HMDB Metabolites of Enzymes	1.0	null
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MDA-MB-415	GDSC Cell Line Gene Expression Profiles	1.0	1.95128
ZR751	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.06538
nadide-5873	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100376_FWM_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.07879
abnormality of the head	GWASdb SNP-Phenotype Associations	1.0	0.090377
H3K4me1_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Anterior cingulate area, dorsal part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30015
GSE114284_1_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Atherosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.81
tetramisole-4587	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K86630280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2446
diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.389281
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08336
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE139016_3_v_2_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
demonstrate	GeneRIF Biological Term Annotations	1.0	null
BRD-K98418950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08589
atypical	GeneRIF Biological Term Annotations	1.0	null
GTEX-SUCS-1826-SM-32PM1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952797
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7438-11A-01R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
among	GeneRIF Biological Term Annotations	1.0	null
STAT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8473
CRCGN015_HEPG2_48H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12126
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.487
Linoleic acid metabolism	KEGG Pathways 2026	1.0	null
SKNBE2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.71686
BRD-K11516621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85241
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
C21orf58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03714
Liver bud hepatic cell_Liver_Human	CellMarker Gene-Cell Type Associations	1.0	null
Developmental disorder of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.603
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.744
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Right_Ventricle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.32216
superficial stratum of r9Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44585
proteasome accessory complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.332848
GTEX-WHSE-1126-SM-3NMBU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
dorsal part of m2A	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.09123
Sarcoma_SARC_TCGA-RN-A68Q-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DGKE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00499819
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
NADPH	HMDB Metabolites of Enzymes	1.0	null
COV318	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.989532
H3K27me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SKMM2	CCLE Cell Line Gene CNV Profiles	-1.0	-2.19962
primary pulmonary hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.32774
plant reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068221
plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.332095
GSE261563_3_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
TUFM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14783
PXR (PXR:RXR)	MotifMap Predicted Transcription Factor Targets	1.0	null
16265353-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
Field CA1, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14899
proteasome regulatory particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.335864
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.346
outer CP in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.983003
NHERF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05227
MAML1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24432
TCEAL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03628
Inflammatory mediator regulation of TRP channels	KEGG Pathways 2026	1.0	null
CCDC115	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20875
PMC8016886-41419_2021_3630_MOESM6_ESM.xlsx-Sheet1-Table_S5_Differentially_expressed_genes_identified_between_HOXC6-low_and_HOXC6-high_expression_CRCs_using_TCGA_cohort_HOXC6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K72359187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70508
LNCAP	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K74641261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08489
fragment	GeneRIF Biological Term Annotations	1.0	null
ATP6V1G1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.924
GSE207863_0_v_1_hdac5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K54332480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99392
GTEX-QCQG-1626-SM-48U26	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831754
Lung adenocarcinoma_LUAD_TCGA-95-7944-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.976
Asthma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K41334119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62578
retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.058674
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Severe Combined Immunodeficiency	DisGeNET Gene-Disease Associations	1.0	null
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
SOX2-20726797-SW620-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.540442
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058108
PUM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73456
BRD-K37912617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95863
19(S)-HETE	HMDB Metabolites of Enzymes	1.0	null
fat_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.828501
ID1_01_133	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.11171
renal proximal tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.743389
Retrosplenial area, lateral agranular part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24498
MEIS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39095
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
ion channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.536183
TRAPPC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83117
537 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.64381
Histone locus body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.241
proton-transporting ATP synthase complex, coupling factor F(o)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.717
496100507_FWM_dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.07398
Middle Cerebral Artery Occlusion	DisGeNET Gene-Disease Associations	1.0	null
Tca-8113 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.76
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_result_of_MR_analysis_and_sensitivity_analysis_for_DLco_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.64461
15S-HpETE	MW Enzyme Metabolite Associations	1.0	null
POLR2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74357
CCLFPEDS0003T	DepMap CRISPR Gene Dependency	1.0	3.19882
ANKS1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37719
TLX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3858
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.832179
Vitamin D3	HMDB Metabolites of Enzymes	1.0	null
GSE205163,GSE205164_3_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.70532
Perturb_3928_KO_KMT2A_SRP277158	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-WFG8-0726-SM-3GILP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22813
long-chain fatty acid metabolic process	GO Biological Process Annotations 2023	1.0	null
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE210101,GSE210114_2_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U8T8-0326-SM-3DB93	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.729797
lipid metabolic process	GO Biological Process Annotations 2025	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8HM-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
regulation of heart contraction	GO Biological Process Annotations 2023	1.0	null
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.955609
BRD-K91469267	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4726
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K34501072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13515
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.43409
H3K9me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
nitrendipine-336	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K13390322_AT-7519_MDAMB231_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CDK9_druginhibition_183_GSE48258	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	0.16832
GSE233679_6_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CADM1_Deficiency_GDS2027_722_mouse_Testis	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CKAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1743
JAK1_knockdown_160_GSE37012	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.39357
BRD-K13502206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54102
cyp2j2	GeneRIF Biological Term Annotations	1.0	null
cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.5597
BRD-K71622214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03058
BRD-K91459693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26069
cellular catabolic process	GO Biological Process Annotations 2015	1.0	null
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PF-00562151-00-6907	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Essential Hypertension	DisGeNET Gene-Disease Associations	1.0	null
GSE226544_1_v_0_hnrnpa2b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K70791360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41527
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
withaferin A-4376	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K98961458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89769
Active peptic ulcer disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.286
CHUK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00470478
Fetal serum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.511
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.262
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.994584
APOL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40181
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.85388
GSE146687_2_v_5_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
liver	HPA Tissue Gene Expression Profiles	1.0	0.975804
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07882
PPP1CC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38576
allele	GeneRIF Biological Term Annotations	1.0	null
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ3S-0126-SM-4BOO9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.929517
BRD-K79090631_CGP-60474_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10528072-NIHMS1928302-supplement-5.xlsx-ASCL1-target_genes-ABAT_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
CHMP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28634
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.71608
Rectum adenocarcinoma_READ_TCGA-DY-A1DF-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pulmonary edema	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.114
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.07026
19S-HETE	MW Enzyme Metabolite Associations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5892-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ARPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60528
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ALK_KD_GDS2724_105_human_DAOY medulloblastoma cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-PWN1-1826-SM-2S1PE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
caudal prosubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.05773
BRD-K38955287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0776
PMC11167905-10194_2024_1805_MOESM1_ESM.xlsx-S6-Table_S6_MR_results_of_brain_eQTLs_and_migraine_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-O5YT-0326-SM-32PKA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937315
ULK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00505071
BRD-K37271110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06283
CRCGN010_HEPG2_24H:G20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7017
H3K4me1_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC6932815-ppat.1007634.s015.xlsx-ST5_DGE_ELF1-R8AvIFN48-mock_lfc-external_gene_name_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22345
PMC7887593-ADVS-8-2003526-s002.xlsx-TT_AR_vs_BR-Gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OXRL-1826-SM-2YUMV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01591
FOXA1-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WOFM-1726-SM-3MJFA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
pulmonary artery endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.170129
levonorgestrel-4269	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Dorsomedial nucleus of the hypothalamus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63177
CRCGN012_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58458
parietal cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10244
leiomyosarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.184945
metabolize	GeneRIF Biological Term Annotations	1.0	null
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
GSE197850_4_v_0_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
PARP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17428
MNDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1209
MM77	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15071
Brain - Substantia nigra	GTEx Tissue Gene Expression Profiles 2023	1.0	3.96703
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XUZC-1426-SM-4BRV3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25819
GTEX-P78B-0226-SM-3NB1Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14615
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
r287q	GeneRIF Biological Term Annotations	1.0	null
BL5624 (AKAP2)	NURSA Protein Complexes	1.0	null
Foxj3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.6143
CYP11B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00716725
SW1463	CCLE Cell Line Gene Expression Profiles	1.0	1.49994
GTEX-PX3G-0326-SM-2I3EO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21926
GSE161846,GSE161849_1_v_5_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
recovery	GeneRIF Biological Term Annotations	1.0	null
FIS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22744
Fatty acid metabolism	Reactome Pathways 2024	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7304-01A-12R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7261-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
endoplasmic reticulum membrane	GO Cellular Component Annotations 2015	1.0	null
GTEX-S7SF-1826-SM-3K2AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
pressure	GeneRIF Biological Term Annotations	1.0	null
BRD-K87472370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23443
SOX2-20726797-SW620-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
M040416	DepMap CRISPR Gene Dependency	1.0	2.22424
ISG15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00796782
FSBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95183
AHCYL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.347
PMC10918910__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
TMEM81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28155
dlx4_00000000_mcfdash7_gof_human_gpl201_gse21657	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.014652
EFM19	DepMap CRISPR Gene Dependency	1.0	2.40041
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942093
BRD-K51275565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36885
Plastid thylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.512
Perturb_9657_KD_NKX25_SRP306591	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
tanespimycin-6926	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HNF4A	Pathway Commons Protein-Protein Interactions	1.0	null
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.15073
monooxygenase activity	GO Molecular Function Annotations 2015	1.0	null
PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1d-List_of_2302_of_genes_differentially_regulated_by_SOX2_FDR_0_1_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
JHH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.850969
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A680-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.872702
BRD-K51385533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27687
GSE166783_0_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
icosanoid metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE150055_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
FUNDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11209
BRD-K99545815_HY-10459_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K32925057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44421
overexpression	GeneRIF Biological Term Annotations	1.0	null
thyroid_5c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.828058
GSE213228_2_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K87909389_alvocidib_HS578T_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.598067
PMC3888473__F3	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-WFJO-0726-SM-4LVM8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832652
superficial stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.10078
GTEX-Q2AG-0008-SM-48U2K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0531
PMC5703746-Table1.XLSX-ST6_MAF-GENE_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.471
fruit	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.072592
GTEX-SN8G-0526-SM-32PLE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06883
cardiomyocytes	GeneRIF Biological Term Annotations	1.0	null
KRI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15389
inflammatory	GeneRIF Biological Term Annotations	1.0	null
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.384172
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
PPP1CB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61394
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61I-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226285_3_v_0_nr0b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XMK1-1126-SM-4IHJ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
diabetes	GeneRIF Biological Term Annotations	1.0	null
ciclosporin-261	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
Torsades de Pointes	CTD Gene-Disease Associations	1.0	1.18783
CW-2	GDSC Cell Line Gene Expression Profiles	1.0	1.54646
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE158834_1_v_6_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-WY-A85D-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Endothelial Dysfunction	DisGeNET Gene-Phenotype Associations	1.0	null
ASPA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00899462
dorsal part of m1A	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18735
Aortic smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.897
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
GSE210101,GSE210114_8_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.182
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.28395
MAZ	ENCODE Transcription Factor Targets	1.0	null
CRCGN014_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3122
GTEX-S4Z8-0926-SM-4AD6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.956648
ATL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.35267
CRCGN011_HEPG2_24H:O09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13985
DDX39A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55318
UBE4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22593
SPZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2995
SP in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10281
anterior (rostral) cingulate (medial prefrontal) cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.996925
CRCGN017_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.2609
level	GeneRIF Biological Term Annotations	1.0	null
A-CA-04-2009(H1N1)_24Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.09794
NLRC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00444632
GSE202434,GSE202438_12_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Primary visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10343
dienestrol-3448	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Arterial smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.022
GTEX-X62O-1626-SM-46MW9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933997
GTEX-RWS6-2326-SM-2XCB4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
GTEX-PVOW-0726-SM-2XCF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1852
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A0C8-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-DX-A3UB-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
PMC5404927-elife-24463-supp2.xlsx-2b_ERM_true_positive_list-Gene_names_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K88156935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35959
ROS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00751567
RBSN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58449
Tachycardia, Ventricular	CTD Gene-Disease Associations	1.0	1.24275
H3K4me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POU2F1-35413990-HUMAN-ARPOSCRPROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE128844_0_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsal lateral geniculate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.859789
diabetees	GeneRIF Biological Term Annotations	1.0	null
EPHA7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00593623
GSE175787_5_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K55538850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28903
PTDSS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9319
3-acetamidocoumarin-4601	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
plasma membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.230601
GTEX-WL46-0526-SM-3LK7W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14018
heme binding	GO Molecular Function Annotations 2023	1.0	null
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.821
hippocampus (hippocampal formation)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.867244
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.35774
PMC9253713-mmc3.xls-sufu_KD_HCC1954_DEGs-Supplementary_Table_2_Differentially_expressed_genes_upon_knockdown_of_SUFU_compared_to_control_in_HCC1954_cells_Related_to_Figure_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TF1	CCLE Cell Line Gene CNV Profiles	1.0	1.58337
bronchial smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.476201
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.920771
Lung adenocarcinoma_LUAD_TCGA-55-7725-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RWSA-0526-SM-2XCBC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.984638
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.89034
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K25147028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80032
ventral medial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.71162
Anterior hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04899
SW837	CCLE Cell Line Gene CNV Profiles	-1.0	-1.88062
GTEX-T8EM-0626-SM-4DM62	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824903
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Anterolateral visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07649
GTEX-UJHI-0226-SM-4IHJL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874245
especially	GeneRIF Biological Term Annotations	1.0	null
ESR1	JASPAR Predicted Transcription Factor Targets	1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DTWD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72602
coronary artery endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.07353
Renal proximal tubule epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.707
Terfenadine	HMDB Metabolites of Enzymes	1.0	null
GABRD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34793
U20S	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.91929
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.03636
BRD-K36055854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39255
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.878286
Forearm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.248
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.73834
BRD-K00137579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83931
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.289226
496100578_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.59936
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02279
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31451
medial intermediate part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.40627
binding	GO Molecular Function Annotations 2015	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7406-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F6_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K50000283_PHA-767491_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
form	GeneRIF Biological Term Annotations	1.0	null
GSE166783_4_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
retinal ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.237009
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29T-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WEY5-0426-SM-3GIKT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02022
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE242555_1_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GLT8D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55461
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO800	DepMap CRISPR Gene Dependency	1.0	2.04989
Ebolavirus(EBOV)_7day_Splenocytes_19683682_GSE17509	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.48988
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
glucose metabolism disease	GWASdb SNP-Disease Associations	1.0	0.226299
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
asthma	GeneRIF Biological Term Annotations	1.0	null
alpha-estradiol-4434	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
dorsolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.43985
participant	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF846	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38686
BRD-K50479239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16256
vivo	GeneRIF Biological Term Annotations	1.0	null
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.847
tooth disease	GWASdb SNP-Disease Associations	1.0	0.318206
myocardial	GeneRIF Biological Term Annotations	1.0	null
496100637_FWM_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00437
bronchial smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.314409
BRD-K63209730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39928
BRD-K60521891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14124
PMC11976269-41375_2025_2519_MOESM3_ESM.xlsx-ChIP_GATA2_Cluster_B-GeneName_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8387919-mmc2.xlsx-ST2_NEUROG3_binding_sites-Unnamed_13_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K44828787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60456
SYPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36806
GTEX-X5EB-2626-SM-4E3HZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17609
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
Prostate adenocarcinoma_PRAD_TCGA-CH-5767-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K46951445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24203
ARVCF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30352
12,13-EpOME	HMDB Metabolites of Enzymes	1.0	null
abnormality of the mouth	GWASdb SNP-Phenotype Associations	1.0	0.143852
ZNF567	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.42462
Vitamin D-dependent rickets	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.149
Intracellular canaliculus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.706
posterior group of nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.41084
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
Brain Lower Grade Glioma_LGG_TCGA-DB-A75O-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6192420__F2	PFOCR Pathway Figure Associations 2023	1.0	null
pepstatin-3264	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NTERA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.6257
BRD-K46790201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13474
18318837-TableS1	GeneSigDB Published Gene Signatures	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
GRB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6747
MK-886-264	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K23585987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26701
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I7-01A-21R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SFT2D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73275
BRD-K31437957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04216
NFKB1	JASPAR Predicted Transcription Factor Targets	1.0	null
apoplexy; stroke	GAD Gene-Disease Associations	1.0	null
heart muscle	HPA Tissue Gene Expression Profiles	1.0	1.03475
Brain Lower Grade Glioma_LGG_TCGA-P5-A731-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC3376834-emmm0004-0052-SD2.xlsx-NR2E3_Specific_1847-Unnamed_1_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF592	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58352
Myocarditis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.007
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.7241
Zic3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.0806
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K06543683_Ro 31-8220 mesylate_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE133516_5_v_1_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130437_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K20271744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54565
ARHGAP33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68571
OCT4-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
14,15-Epoxy-5,8,11-eicosatrienoic acid	HMDB Metabolites of Enzymes	1.0	null
ddt1-mf-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.394953
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25093
Terfenadine	DrugBank Drug Targets	1.0	null
against	GeneRIF Biological Term Annotations	1.0	null
BRD-K60635455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14971
Parathion	HMDB Metabolites of Enzymes	1.0	null
ACHN cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.712
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LI-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
premature	GeneRIF Biological Term Annotations	1.0	null
betaadrenergic	GeneRIF Biological Term Annotations	1.0	null
16356477-Table1	GeneSigDB Published Gene Signatures	1.0	null
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.426711
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Atherosclerosis	DisGeNET Gene-Disease Associations	1.0	null
GSE145249_1_v_3_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-224	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
profenamine-3038	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
congestive heart failure	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.141656
19605494-TableS2	GeneSigDB Published Gene Signatures	1.0	null
BRD-K82102697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38957
Astemizole	DrugBank Drug Targets	1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Anoxia	DisGeNET Gene-Phenotype Associations	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NOD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00447361
diabetes, type 2; hypertension; diabetes, type 1	GAD Gene-Disease Associations	1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1218
KIF2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98209
Diabetes Mellitus, Type 1	HuGE Navigator Gene-Phenotype Associations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV4-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
4-hydroxy-2-nonenoic acid	CTD Gene-Chemical Interactions	1.0	null
CCDC153	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05645
liver cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07302
Atrial Fibrillation	DisGeNET Gene-Disease Associations	1.0	null
Folic Acid Deficiency	DisGeNET Gene-Disease Associations	1.0	null
POT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10205
GTEX-UPK5-0226-SM-3GAEV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60487
GTEX-WFG7-1726-SM-4LVME	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858399
BRD-K92440102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05169
KMS28BM	CCLE Cell Line Gene CNV Profiles	-1.0	-2.07189
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.105
potentiation	GeneRIF Biological Term Annotations	1.0	null
LHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43369
rs890293	GeneRIF Biological Term Annotations	1.0	null
Myocarditis	CTD Gene-Disease Associations	1.0	1.01137
Inflammatory bowel disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.334
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Tfcp2l1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	58.9897
anthelmintics	GeneRIF Biological Term Annotations	1.0	null
COPZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76943
Taenia tecta, ventral part, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25275
selectively	GeneRIF Biological Term Annotations	1.0	null
caucasians	GeneRIF Biological Term Annotations	1.0	null
Renal fibrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
hsa-miR-4732-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
NEURL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72702
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor-sensory cortex (samples)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.871682
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-WT-gene_symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
EMX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.12962
JcPL part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14827
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K06876397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1893
Entorhinal area, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54901
attenuated	GeneRIF Biological Term Annotations	1.0	null
structural	GeneRIF Biological Term Annotations	1.0	null
SLC7A8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85958
BRD-K45056520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63093
GRIK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50535
SHC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48325
cardiovascular	GeneRIF Biological Term Annotations	1.0	null
HCC70	CCLE Cell Line Gene CNV Profiles	1.0	1.4227
represent	GeneRIF Biological Term Annotations	1.0	null
GTEX-QDT8-0426-SM-32PKZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01965
Lung squamous cell carcinoma_LUSC_TCGA-O2-A52W-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K45092891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71226
Aortic aneurysm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
BRD-K11168234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15711
BRD-K01152687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31371
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EK-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
modify	GeneRIF Biological Term Annotations	1.0	null
GTEX-T6MO-1726-SM-33HB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20914
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-D_eGFP_vs_WT-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K35963610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18691
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-RXRG_RXRG	Rummagene Transcription Factor Associations 2026	1.0	null
flecainide-3761	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
prochlorperazine-5212	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lovastatin-6633	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Hepa-RG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.244
reticular nucleus of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15458
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
infarct	GeneRIF Biological Term Annotations	1.0	null
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.581
Ppara	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.1922
BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
frontal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.859973
HNFA-21074721-CACO-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Fog2_KO_GDS3659_152_mouse_adult heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
architecture	GeneRIF Biological Term Annotations	1.0	null
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.89161
MRPL13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26721
H6PD_KO_GDS3195_603_mouse_Skeletal muscle - Tibialis anterior	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CFTR_Deficiency_GDS1843_191_mouse_Lungs - Animals examined at 3 weeks of age	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
transplant	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
isthmic roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18614
biosynthesis	GeneRIF Biological Term Annotations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4151-01A-01R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Myocardial Ischemia	HuGE Navigator Gene-Phenotype Associations	1.0	null
CRCGN008_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5904
heart	GTEx Tissue Gene Expression Profiles	1.0	0.974361
TCEB1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Heart Diseases	CTD Gene-Disease Associations	1.0	1.34459
glial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.717061
PMC9374162-mmc4.xls-KD_gene_list_heatmap_235_genes-Gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K60946512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.58022
Parathyroid gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.864
BRD-K98927248	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57437
BRD-K76755163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59711
CAMA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.54096
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
496100579_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.0188
suggests	GeneRIF Biological Term Annotations	1.0	null
BRD-K88573743_A443654_HS578T_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LEFTY1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00413183
HCT-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
plant form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066926
BRD-K53561341_KIN001-220_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1MH-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-V1D1-0626-SM-4JBHN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59335
ACHE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76667
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.92456
BRD-K87779720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12964
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.831201
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
interactions	GeneRIF Biological Term Annotations	1.0	null
liver	GeneRIF Biological Term Annotations	1.0	null
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-B_FUS-DDIT3-eGFP_vs_WT-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
nasal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.220378
endoplasmic reticulum membrane	GO Cellular Component Annotations 2023	1.0	null
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_9104_KD_KDM4C_SRP202026	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.13754
17823660-TableS2	GeneSigDB Published Gene Signatures	1.0	null
Diabetic retinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
CRCGN009_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28175
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K93788137_PF-431396_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.61883
Anterior hypothalamic nucleus, central part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06909
TNFRSF11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87197
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
importance	GeneRIF Biological Term Annotations	1.0	null
Coronary Artery Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
HEL9217	CCLE Cell Line Gene CNV Profiles	1.0	1.39798
GTEX-S341-1626-SM-3K2B8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
carious teeth	GWASdb SNP-Phenotype Associations	1.0	0.561769
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.21
hsa-miR-548ai	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
BRD-K67817697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3269
Kidney Chromophobe_KICH_TCGA-KL-8332-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW872	GDSC Cell Line Gene Expression Profiles	-1.0	-1.48879
Mecom	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.6296
cuneus, left, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05378
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.432
Retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.273
CRCGN010_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09262
GFY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59813
Lung squamous cell carcinoma_LUSC_TCGA-68-A59I-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE160817_5_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CDK7_knockdown_138_GSE31534	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.00102
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Coronary Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30812
BRD-K67859584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07332
GTEX-XUYS-0226-SM-47JX1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.956992
DLD1	BioGPS Cell Line Gene Expression Profiles	1.0	2.41625
BRD-K41192699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5167
MED31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38419
quinisocaine-2807	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
imatinib_homo sapiens_gpl96_gds3044	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Fatty acids	Reactome Pathways 2024	1.0	null
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRL-0326-SM-2I3F2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42284
PMC6697777__F7	PFOCR Pathway Figure Associations 2023	1.0	null
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058297
BRD-U82589721_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PK-45P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42528
CRCGN016_MCF10A.WT.HP_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.23528
BRD-K58017833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12781
CGNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18736
GSE158834_1_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5159-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
21205295-TableS5	GeneSigDB Published Gene Signatures	1.0	null
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.5103
deep layers of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.71107
BRD-K87909389_alvocidib_HA1E_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
epoxygenases	GeneRIF Biological Term Annotations	1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6126969-NIHMS979612-supplement-4.xlsx-Tab_1_ERM_proteins-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
PHA-00767505E-6550	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cardiac	GeneRIF Biological Term Annotations	1.0	null
MDAMB415	CCLE Cell Line Gene Expression Profiles	1.0	2.29624
complications	GeneRIF Biological Term Annotations	1.0	null
N-acetyl-L-aspartic acid-4007	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K04628654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19476
GSE126463_5_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NPHS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00504981
egfr	GeneRIF Biological Term Annotations	1.0	null
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
topology	GeneRIF Biological Term Annotations	1.0	null
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.451
ABL1_knockdown_137_GSE31534	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.80161
BRD-K04546108_JAK3 Inhibitor VI_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8324-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K80210288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08341
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
other	GeneRIF Biological Term Annotations	1.0	null
Biological oxidations	Reactome Pathways 2024	1.0	null
GTEX-WFG7-2326-SM-3GIKV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
hsa-miR-299-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
layer 2 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70328
Diabetes Mellitus	DisGeNET Gene-Disease Associations	1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.588
subdural space	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.462626
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JF-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
coronary artery disease;	GAD Gene-Disease Associations	1.0	null
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EJ-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COV318	CCLE Cell Line Gene CNV Profiles	1.0	1.35115
inhibitorsinduced	GeneRIF Biological Term Annotations	1.0	null
BRD-K50689779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46502
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-S95S-1326-SM-2XCDK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879926
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PF-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NFYB-21822215-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE234514,GSE234516_2_v_0_mitf_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
Peptic ulcer disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
HDAC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00124
BRD-K68485855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57695
arachidonic acid 11,12-epoxygenase activity	GO Molecular Function Annotations 2015	1.0	null
salicyl-alcohol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10077
NFIC::TLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.0625
PMC11602576-mmc11.xlsx-ST12-Table_S12_Output_of_mash_model_of_milk_and_GTEx_eQTL_effects_Related_to_Figure_2_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXL1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE164874_5_v_10_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cortical collecting duct cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.928
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.47875
BRD-K13390322_AT-7519_HCC515_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.36504
monobenzone-5312	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
thioridazine-1486	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
danazol	GeneRIF Biological Term Annotations	1.0	null
unsaturated fatty acid metabolic process	GO Biological Process Annotations 2015	1.0	null
MAN2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.45807
should	GeneRIF Biological Term Annotations	1.0	null
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.205
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARS-CoV_48Hour_20090954_GSE17400	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.52477
scoulerine-5536	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
chemdependency	GAD High Level Gene-Disease Associations	1.0	0.293278
PMC2866657-pone.0010547.s003.xls-ESE3_corr-Genes_correlated_anticorrelated_to_ESE3_EHF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K43389698_BMS-387032_HS578T_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
macroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.699035
FOXA1	ENCODE Transcription Factor Targets	1.0	null
Asthma	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE174701_5_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K43982279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61709
Tumor Progression	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-R55G-1226-SM-48FDC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915886
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PW2O-0226-SM-48TC7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975033
Primary somatosensory area, barrel field, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55449
Olfactory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.166
GSE223893_1_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FW-A5DX-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K99953989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92718
POU2F1::SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.9226
PMC10742386-pnas.2311372120.sd05.xlsx-DLX3_ST-Gene_Symbol_DLX3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K55414200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82397
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DB-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAP3K7_knockout_246_GSE34417	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.65896
PSN1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26298
Periventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17876
RP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00550125
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.950393
JAR	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Oxygen	HMDB Metabolites of Enzymes	1.0	null
Cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.996
Msgn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.9649
SU-DHL-8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S341-2026-SM-2XCAA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
Lung squamous cell carcinoma_LUSC_TCGA-22-A5C4-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
1,4-dihydroxy-2-nonene	CTD Gene-Chemical Interactions	1.0	null
BRD-K88573743_A443654_MDAMB231_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
IRF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1537
VCX3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7785
Lung squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.661
PMC8582123-13073_2021_996_MOESM3_ESM.xlsx-AIRE-HIT_AIRE	Rummagene Transcription Factor Associations 2026	1.0	null
carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.210589
size	GeneRIF Biological Term Annotations	1.0	null
GTEX-WFON-1426-SM-4LVMT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883642
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.54825
relevant	GeneRIF Biological Term Annotations	1.0	null
Extrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.098
BRD-K65598127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48233
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SE5C-0626-SM-2XCDV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47839
CRCGN008_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1378
HCC827	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.40458
Endoplasmic reticulum membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GTEX-OIZF-1526-SM-3MJGY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39405
CRCGN011_HEPG2_24H:N06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25385
artery	GeneRIF Biological Term Annotations	1.0	null
paracentral lobule, posterior part, left, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.01595
responsible	GeneRIF Biological Term Annotations	1.0	null
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Paraventricular hypothalamic nucleus, parvicellular division, medial parvicellular part, dorsal zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.76573
occipital pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.79527
VAC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14428
Heart conduction disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.988
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6959-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
outer SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.883433
Arteriole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.672
EPLC272H	CCLE Cell Line Gene CNV Profiles	1.0	2.09602
Other Ureteric Obstruction	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K25387295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83324
nicergoline-5775	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE223893_1_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
catalytic	GeneRIF Biological Term Annotations	1.0	null
TXNIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36776
layer I of piriform cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.97644
RPS20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51368
endomembrane system	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.956
Memory Disorders	CTD Gene-Disease Associations	1.0	1.61061
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.5512
BRD-K87909389_alvocidib_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
estradiol-6957	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K79me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K27945483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34313
Primary motor area, Layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06958
TRIM28_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.068381
KMRC3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.73424
CRCGN015_MCF10A.TP53.M_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4507
smallintestine_4c	HPA Tissue Sample Gene Expression Profiles	1.0	1.20754
GTEX-R53T-0326-SM-48FEC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5291
GTEX-PLZ5-0626-SM-2I5F8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3649
smallintestine_4d	HPA Tissue Sample Gene Expression Profiles	1.0	1.16729
Lung adenocarcinoma_LUAD_TCGA-55-7914-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN009_HEPG2_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02029
CACNB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00640943
BRD-K27864398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93411
uygur	GeneRIF Biological Term Annotations	1.0	null
GATA6-21074721-CACO-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10698
BRD-K64451058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15354
GTEX-QEG4-0426-SM-33HC3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5616
BRD-K47471281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29138
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K45819372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18344
myocardial infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.348614
600MPE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.785648
PMC5404269__F8	PFOCR Pathway Figure Associations 2023	1.0	null
GSE216273,GSE216292_0_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Metabolic disorders of biological oxidation enzymes	Reactome Pathways 2014	1.0	null
BRD-K64353626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11025
PMC12822963-pone.0339296.s005.xlsx-Sheet1-HIF1A_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
19036130-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
Liver cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.099
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32666
BRD-K85336956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80973
SMARCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62494
PRELID1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.08686
SK-MES-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.661
CALCRL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00597777
PMC3888473__F3	PFOCR Pathway Figure Associations 2024	1.0	null
cyp3a4	GeneRIF Biological Term Annotations	1.0	null
Lung-respiratory goblet cell	Tabula Sapiens Gene-Cell Associations	1.0	2.78956
GSE193258,GSE193259_9_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
chr1_59913164_A_C_b38	GTEx eQTL 2025	1.0	1.02243
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.525
hpaec cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.308251
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8747
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRDM15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56384
5152487-896	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
bacterial	GeneRIF Biological Term Annotations	1.0	null
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.734
PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_12_in_RNA-seq_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BLM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23343
GSE216273,GSE216292_14_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.12403
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BT-549	GDSC Cell Line Gene Expression Profiles	-1.0	-1.71917
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_10_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K53559383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48498
Renal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.116
PCYT1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38653
ROCK_INHIBITION_GDS3944_462_mouse_Forebrain astrocytes - 6 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-PSDG-0926-SM-2I5FP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24394
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X261-0011-R6B-SM-4E3J8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08237
Fatty acids	Reactome Pathways 2014	1.0	null
BRD-K95010912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48514
PMC5417597-pone.0176679.s006.xlsx-Tumor_MLL_vs_Control-Unnamed_1_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GI-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.12225
teeth hard tissue disease	GWASdb SNP-Disease Associations	1.0	0.658446
GSE210870_0_v_1_snai1_human	RummaGEO Gene Perturbation Signatures	1.0	null
protects	GeneRIF Biological Term Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4582-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.887208
Serotonergic synapse	KEGG Pathways 2026	1.0	null
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	Reactome Pathways 2024	1.0	null
estradiol-373	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MDAMB415	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.41606
GTEX-R53T-0926-SM-3GADH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56332
LIN28A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67748
BRD-K89305325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3835
H3K79me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
capillary	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.512957
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-d-Classification_of_camel_SON_basal_genes_-_enzymes_SON	Rummagene Transcription Factor Associations 2026	1.0	null
theobromine-6613	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K42511168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23939
CAPAN2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3309
Sox6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.4538
PMC12712253-12672_2025_4014_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_for_PC_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P7-A5NX-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GPRC5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50798
H3K27me3_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K19220233_JNK-9L_HME1_3_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.388
clindamycin-7172	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
membrane region	GO Cellular Component Annotations 2015	1.0	null
GATA6-21074721-CACO-2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
YKG1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.58276
MTERF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.22479
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
cuneate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.940289
USP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86281
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I8-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9198
Juice	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.317
Olig2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.8537
Anterolateral visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31557
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN011_HEPG2_24H:C16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12535
ESRRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2673
GTEX-UTHO-1826-SM-3GAFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31942
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.1978
seed	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069128
A-CA-04-2009(H1N1)_36Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.74983
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.052
CEP120	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.65086
smoothmuscle_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.3048
CRCGN015_MCF10A.WT.HP_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06974
Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.1783
stroke	GeneRIF Biological Term Annotations	1.0	null
SEC14L2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00486832
MDA-MB-330	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.32901
Congestive Heart Failure	DisGeNET Gene-Disease Associations	1.0	null
SARS-CoV MA15_Day1-PFU-10^5_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.86675
Hyperhomocysteinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
TMEM200A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41976
anterior group of nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.961511
GSE234514,GSE234516_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CL34	CCLE Cell Line Gene Expression Profiles	1.0	1.35777
AICD_Induced  expression / Over-expression_GDS1979_288_human_SHEP-SF neuroblastoma	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PCDHB12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03359
HSF1_KD_GDS1733_757_human_HeLa cells - 4 Hour by siHSF1_2	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
TNFRSF9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.005407
BRD-K76677554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23431
GTEX-UJHI-0426-SM-3DB8Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01718
MAP3K20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00633445
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.24996
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
Enterocyte progenitor cell_Small intestine_Human	CellMarker Gene-Cell Type Associations	1.0	null
ischemic coronary and cerebrovascular events	GAD Gene-Disease Associations	1.0	null
16877703-TableS2	GeneSigDB Published Gene Signatures	1.0	null
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3551
CHD2	ENCODE Transcription Factor Targets	1.0	null
Asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.343
Pancreatic adenocarcinoma_PAAD_TCGA-F2-6879-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myocardial Infarction	DisGeNET Gene-Disease Associations	1.0	null
membrane-bounded vesicle	GO Cellular Component Annotations 2015	1.0	null
BRD-K91426044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6119
active	GeneRIF Biological Term Annotations	1.0	null
GSE211215_1_v_0_pemetrexed_human	RummaGEO Drug Perturbation Signatures	1.0	null
N-phenylanthranilic acid-317	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27339
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brain - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.709307
BRD-K63154470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10831
GSE178532_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4969-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.857378
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-PWCY-0226-SM-48TD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.966543
aorta	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.841188
GSE146687_2_v_1_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
carriers	GeneRIF Biological Term Annotations	1.0	null
TEX261	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.49264
Mitochondrial permeability transition pore complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.342
Gustatory areas, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09533
GSE135030_8_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TNKS_INHIBITION_GDS5029_281_human_SW480 KRAS-mutant colorectal cancer cell line - 16hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PPP6R2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05707
PMC12518476-10067_2025_7574_MOESM9_ESM.xlsx-Sheet2-RNAseq_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Primary somatosensory area, mouth, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25844
H3K4me3_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Paraventricular hypothalamic nucleus, magnocellular division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52002
BRD-K79159743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04382
bleomycin-sulfate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02014
carboxyl	GeneRIF Biological Term Annotations	1.0	null
GTEX-QLQ7-0526-SM-2I5G3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07024
BRD-K76966915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17898
GSE229973_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ATG4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43357
ARPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96534
15505275-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
2-phenylmelatonin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79615
HCC3153	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.679413
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PWCY-2226-SM-2S1OP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08695
HCC38	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.04932
GSE80537_3_v_2_adhfe1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
INSM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06853
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.97428
GTEX-PSDG-0526-SM-2S1OH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Renal proximal tubule cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.005
HDAC2	ENCODE Transcription Factor Targets	1.0	null
AR-27623747-22RV1-MOUSE-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
SOX2-21211035-LN229-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
major	GeneRIF Biological Term Annotations	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-A7CW-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135030_11_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92115
docosahexaenoic acid ethyl ester-881	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Renal proximal tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.539
KLF4-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.958686
juice	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.22415
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.40458
SPATA2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44597
GTEX-WK11-0626-SM-3NMAV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31356
BRD-K43051162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54243
ZNF679	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1175
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
PMC4782046-supp_30.5.508_TableS2.xlsx-TAL1_UTX-co-bound_genes-Table_S2_List_of_TAL1_UTX_co-bound_genes_in_Jurkat_cells_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.836
RAPGEFL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52986
Oxidation by Cytochrome P450(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
Clara cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.565
VAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34217
BRD-K99749624_S1003_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE223908,GSE223909_1_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.60051
17414055-Table2	GeneSigDB Published Gene Signatures	1.0	null
GSE164874_5_v_3_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
d11	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.605
BRD-K13566078_BMS-345541_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
19074870-SuppTable4a	GeneSigDB Published Gene Signatures	1.0	null
dh15	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.622
Formaldehyde	HMDB Metabolites of Enzymes	1.0	null
blood vessel endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.01156
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.21373
BRD-K47756270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44728
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XBED-0526-SM-47JY3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06359
Uterine disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.064173
BRD-K26941844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05152
NRBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36633
accelerated	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K32699895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14947
NCIN87	DepMap CRISPR Gene Dependency	1.0	4.44246
GSE135400_2_v_0_kdm1b_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:E08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02675
TCP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21386
Paraventricular hypothalamic nucleus, magnocellular division, posterior magnocellular part, lateral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.56842
SOX2	ChEA Transcription Factor Targets	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
mouth disease	GWASdb SNP-Disease Associations	1.0	0.276425
arteriosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.322637
alvespimycin-6933	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.973
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05061
NFE2L2_KO_GDS514_699_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-WHWD-0326-SM-3LK6L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14882
Intrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
dock	GeneRIF Biological Term Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A4QR-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.60572
substrates	GeneRIF Biological Term Annotations	1.0	null
ETV5::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.7581
Gut wall	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.114
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11426526-ppat.1012555.s011.xlsx-DEG_MDDC_Jurkat_LPS_vs_MDDC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4496	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
BRD-A20305532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02723
17683518-193GeneTable	GeneSigDB Published Gene Signatures	1.0	null
GTEX-XGQ4-0526-SM-4AT6C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02841
MAFF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00583576
Ascl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	86.6537
Zfp335	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.7381
BRD-K87558616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34369
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
BRD-K79090631_CGP-60474_A549_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
drug metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC5732738-oncotarget-08-103415-s002.xlsx-CAMA1_DEGs-Genes_differentially_expressed_by_1_25_fold_between_parental_CAMA1_cells_and_GATA3_mutant_knock-in_clone_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.026891
GTEX-SIU8-0826-SM-2XCDQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64564
VIPAS39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30656
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE238018_3_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUJ4-2826-SM-4BOQ2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
NANOG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00768989
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5085-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Chloroplast thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.542
Defective CYP19A1 causes Aromatase excess syndrome (AEXS)	Reactome Pathways 2014	1.0	null
GTEX-UJMC-1326-SM-4IHLS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851458
GSE135030_3_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
C2BBE1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28687
19-Oxotestosterone	HMDB Metabolites of Enzymes	1.0	null
arterial smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.735971
Arachidonate metabolism	Reactome Pathways 2024	1.0	null
Lipid metabolism disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.599
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13786
GSE135030_3_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Renal artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.072
GTEX-RU1J-0226-SM-2TF5Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.18041
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TULP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72241
GTEX-XXEK-0926-SM-4BRWH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01113
Myocardial Infarction	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K89832379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41056
BRD-K94277689	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.25742
BRD-K57349002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04061
GSE113952,GSE113953_1_v_0_chtop_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HMGXB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0342
COL4A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48606
dorsal septopreoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23335
type ii diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.425155
Caffeine	HMDB Metabolites of Enzymes	1.0	null
mRNA_NRIP1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Cholecalciferol	DrugBank Drug Targets	1.0	null
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
daudi	HPA Cell Line Gene Expression Profiles	-1.0	-1.05471
Nephritis	DisGeNET Gene-Disease Associations	1.0	null
membrane region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.008503
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.06205
outer CP in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.83863
arteriosclerotic cardiovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.336876
0198306-0000-7099	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22345
amylocaine-4089	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Post Mi	DisGeNET Gene-Phenotype Associations	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.81007
RBPJ-21746931-IB4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Entorhinal area, lateral part, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34849
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.273192
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.04533
cinchonine-2789	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Supplemental somatosensory area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20406
GTEX-WFON-1726-SM-4LVMQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983129
Lung adenocarcinoma_LUAD_TCGA-55-1596-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9013128-NIHMS1795992-supplement-6.xlsx-ARID2_MUT_Dowregulated-Gene_name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
layer 1 of LPrP cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14792
pyridoxine-5813	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K61929684	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28356
PMC12518476-10067_2025_7574_MOESM9_ESM.xlsx-Sheet2-intersection_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1828
12874079-Table3e	GeneSigDB Published Gene Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MY-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral group of nuclei, right, dorsal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.831841
GSE202434,GSE202438_9_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PHA-00745360-3824	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
obesity	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6962-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Autoimmune disease of musculoskeletal system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.163
CBARP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21279
certain	GeneRIF Biological Term Annotations	1.0	null
candidate	GeneRIF Biological Term Annotations	1.0	null
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Night sleep phenotypes	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.569897
effects	GeneRIF Biological Term Annotations	1.0	null
SNU245	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32674
model	GeneRIF Biological Term Annotations	1.0	null
BRD-K73452131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13327
dorsolateral IC periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17386
Mesothelioma_MESO_TCGA-SH-A7BD-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PIK3C2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81232
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.29
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4767
calcium	GeneRIF Biological Term Annotations	1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.122
SPRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90691
GTEX-POMQ-0426-SM-3P61G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16307
Diabetes Mellitus, Type 2	HuGE Navigator Gene-Phenotype Associations	1.0	null
U2OS	DepMap CRISPR Gene Dependency	1.0	3.78691
Liver hepatocellular carcinoma_LIHC_TCGA-NI-A4U2-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_1_v_5_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Hyperglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.35
C11orf68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.943
Nr2e3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.0435
TCF4	ChEA Transcription Factor Targets	1.0	null
GOS3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55292
TAS2R5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88722
Nfat5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.3118
tobacco use disorder	GAD Gene-Disease Associations	1.0	null
GTEX-XUJ4-0526-SM-4BOON	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19087
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
REXO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01927
H3K9me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
clofibrate-263	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QCQG-1426-SM-48U22	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.927611
ap1	GeneRIF Biological Term Annotations	1.0	null
ECC4	DepMap CRISPR Gene Dependency	1.0	2.32477
orbital frontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14179
rofecoxib-463	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08112
mRNA_POU5F1_20526341	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4494-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tissues	GeneRIF Biological Term Annotations	1.0	null
BRD-K76748254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02278
BRD-K89806367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06854
TBRG4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00559003
periventricular stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23707
RS4-11	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SA1-27219007-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE161846,GSE161849_4_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.234
BRD-K66889220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.026
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.8533
developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.064077
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO-678	GDSC Cell Line Gene Expression Profiles	1.0	1.59106
Blood vessel wall	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.271
Lung squamous cell carcinoma_LUSC_TCGA-85-8351-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K65203256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58008
diabetic	GeneRIF Biological Term Annotations	1.0	null
Bhlha15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.7813
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.983739
GTEX-XUZC-1026-SM-4BOPY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.755
H3K27ac_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
glia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.74009
BRD-K30853940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0294
LS180	CCLE Cell Line Gene Expression Profiles	1.0	1.48581
TBPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94226
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4164-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.19
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06657
those	GeneRIF Biological Term Annotations	1.0	null
r9 part of the lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27448
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.522
GTEX-RU72-1426-SM-46MUF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29584
chr1_59914923_G_T_b38	GTEx eQTL 2025	1.0	1.00483
YMB1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44424
coronary	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Protozoan Infection_Intestinal Epithelium_GSE2077	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.51305
CRCGN012_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.972
retroreuniens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2071
Apixaban	DrugBank Drug Targets	1.0	null
GTEX-NPJ8-0226-SM-48TBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03494
E2F6	ENCODE Transcription Factor Targets	1.0	null
TIMM8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03
GSE130956_2_v_1_icaritin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12632
Astemizole	CTD Gene-Chemical Interactions	1.0	null
GSE158834_1_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.914115
Paraventricular hypothalamic nucleus, magnocellular division, medial magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50734
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TNRC6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01161
SNAPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52218
BRD-K33371292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90125
BRD-K48260102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54733
BRD-K11874023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42084
BRD-K73849129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.51921
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A172	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.21564
daphnid	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.536229
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
Luminal cell_Bladder_Human	CellMarker Gene-Cell Type Associations	1.0	null
MAPKAPK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18869
Arachidonic acid	MW Enzyme Metabolite Associations	1.0	null
GSE175787_13_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE161864,GSE161866_0_v_2_ror2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216273,GSE216292_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K37131263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26737
PU.1	MotifMap Predicted Transcription Factor Targets	1.0	null
ATM_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.839
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.124758
DDX27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.49676
plant vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.00763
Perturb_14247_KO_FOXM1_SRP328179	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.76219
PMC10773028-40364_2023_552_MOESM2_ESM.xlsx-Variants_sheet-TFT_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
Pulmonary Disease, Chronic Obstructive	HuGE Navigator Gene-Phenotype Associations	1.0	null
C170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.886314
BRD-K63950697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88593
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.224
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Brain Diseases	CTD Gene-Disease Associations	1.0	1.23169
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K68041793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7482
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93005
GTEX-QDVJ-0426-SM-2I5FW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56992
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T6-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CA4 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.942436
organic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-X62O-0826-SM-46MW8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89039
suggested	GeneRIF Biological Term Annotations	1.0	null
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Aorta endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.282
BRD-K21680192_mitoxantrone_HS578T_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SEMA6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46393
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
x1/5	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.746
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CBLN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3936
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.988743
BRD-K54233340_Dorsomorphin dihydrochloride_NCIH2073_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PROKR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.72705
Entorhinal area, lateral part, layer 2b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46637
TTC32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9402
Nucleus of reunions	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14945
CTV1DM	DepMap CRISPR Gene Dependency	1.0	4.13125
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
shell of p3ZL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28875
GTEX-XQ8I-0226-SM-4BOPM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09318
Nausea	DisGeNET Gene-Phenotype Associations	1.0	null
Xenobiotics	Reactome Pathways 2024	1.0	null
CRCGN013_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04552
blood plasma	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.366754
cyclizine-5100	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DPH5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57287
PcPL part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3118
GTEX-W5WG-1326-SM-4LMI9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940838
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.226
HSF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3991
BRD-K83815133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16119
SLC30A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85873
BRD-K48436333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5515
essential	GeneRIF Biological Term Annotations	1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.754
GSE174701_1_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-V1-A8MF-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.51112
Hoxa11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.0898
PMC7617064-EMS151900-supplement-Figure_7_Source_Data.xlsx-HLC_D9_DEG-Logfold_change_threshold_1_0_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
endoplasmic reticulum membrane	GO Cellular Component Annotations 2025	1.0	null
GSE216540_10_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
COLO205	BioGPS Cell Line Gene Expression Profiles	1.0	1.271
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5585-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pole plasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.18796
UNC13D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.89885
PMC7773148__F1	PFOCR Pathway Figure Associations 2023	1.0	null
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00295
BRD-K00530465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05805
head and face region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12304
DCAF12L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12837
SHQ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54716
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC5543043-data_sheet_2.xlsx-LPS_MDM_module-Upstream_Regulator_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
HCE-4	GDSC Cell Line Gene Expression Profiles	1.0	1.92314
Brn3a_KO_GDS1651_248_mouse_Embryonic (day 13.5) trigeminal ganglia - homozygous	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.522
Lung squamous cell carcinoma_LUSC_TCGA-77-6842-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DIS3L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29716
HCK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00449176
TLR5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00488314
differentiated	GeneRIF Biological Term Annotations	1.0	null
septohypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19479
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.399
19658189-TableS3	GeneSigDB Published Gene Signatures	1.0	null
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.439
SOX2-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
HOXD12::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6726
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
review	GeneRIF Biological Term Annotations	1.0	null
GTEX-S3XE-0426-SM-3K2AC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57016
vascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.52521
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05145
cad	GeneRIF Biological Term Annotations	1.0	null
shoot	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065921
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
piroxicam-2089	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K66707905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04678
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.581
either	GeneRIF Biological Term Annotations	1.0	null
Adipose - Subcutaneous	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.716533
19225562-TableS1	GeneSigDB Published Gene Signatures	1.0	null
alvespimycin-993	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.57835
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00883
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.438
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.27748
ACN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
18801183-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
OCIMY5	CCLE Cell Line Gene CNV Profiles	-1.0	-1.83604
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7009
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.879903
inner CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.47571
DPYSL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67475
GTEx Brain 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	11.917
efficiently	GeneRIF Biological Term Annotations	1.0	null
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney Failure, Chronic	HuGE Navigator Gene-Phenotype Associations	1.0	null
mantle zone of PHyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33376
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.54014
arachidonate metabolic process	GO Biological Process Annotations 2025	1.0	null
GTEX-WFG7-1626-SM-4LVMF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.949986
PARP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32129
BRD-K78344913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62829
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68D-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TERFENADINE	DGIdb Drug Targets 2026	1.0	1.89043
NOP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03072
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)	Reactome Pathways 2014	1.0	null
GSE119978,GSE180930_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.613742
monocarboxylic acid metabolic process	GO Biological Process Annotations 2025	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HI-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K81537454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18822
Coronary artery endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.43
Coronary Artery Disease	DisGeNET Gene-Disease Associations	1.0	null
DRAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00436202
BRD-K66013406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35779
BRD-K81450614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01151
BRD-K61206648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10317
proximal	GeneRIF Biological Term Annotations	1.0	null
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059292
respiratory smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.457214
SCC25	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51287
9,10-Epoxyoctadecenoic acid	HMDB Metabolites of Enzymes	1.0	null
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.24024
GTEX-XUJ4-2026-SM-4BOOW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894548
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.970211
CCL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00567913
Nervous System Malformations	CTD Gene-Disease Associations	1.0	1.4989
Malignant Squamous Cell Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
BRD-K58149231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53193
epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.425726
AK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00604468
POR_KO_GDS1678_760_mouse_Colon	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
vascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.927192
BRD-K10505056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40238
Glaucoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
rostral subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.831436
fastigial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.947886
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-LEF1_UP_V1_DN-Ensemble_gene_ID_LEF1	Rummagene Transcription Factor Associations 2026	1.0	null
fatty acid metabolic process	GO Biological Process Annotations 2023	1.0	null
Hand1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.9087
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
c-Myc_OE_GDS3321_157_mouse_lung adenocarcinomas alveolar epithelia	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
gracile nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.877565
SARS-ddORF6_0Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.63634
Pancreatic adenocarcinoma_PAAD_TCGA-YY-A8LH-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.385
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.333524
CA2 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.57958
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gastrointestinal system disease	GWASdb SNP-Disease Associations	1.0	0.07774
ovary	GTEx Tissue Gene Expression Profiles	-1.0	-0.895242
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.570021
Ovarian Neoplasms	CTD Gene-Disease Associations	1.0	1.39142
PPAN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72225
Msx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.849
MOV10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80999
RP1_KO_GDS1845_190_mouse_Retinas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
19-Hydroxyandrost-4-ene-3,17-dione	HMDB Metabolites of Enzymes	1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.932303
raphe obscurus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.907801
STAT3	ChEA Transcription Factor Targets	1.0	null
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.218049
Masoprocol	DrugBank Drug Targets	1.0	null
KYSE-150	COSMIC Cell Line Gene Mutation Profiles	1.0	null
into	GeneRIF Biological Term Annotations	1.0	null
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.24744
ABHD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58712
MT-ATP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31003
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.945664
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GI-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CACO-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.461
JEKO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41051
GSE96777,GSE96778_1_v_0_zbtb4_human	RummaGEO Gene Perturbation Signatures	1.0	null
PRDM16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13582
BRD-K18074484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09853
Adrenocortical carcinoma_ACC_TCGA-OR-A5K0-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
biomarker	GeneRIF Biological Term Annotations	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A819-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20474
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.311
GSE195568_2_v_4_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HES3_KO_GSE64449_186_mouse_Min6	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PAFAH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82456
Perturb_6476_KO_SETD6_SRP341895	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE174701_5_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Dami cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.749
periventricular stratum of m2ADL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58762
acebutolol-6631	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4133-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2998	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-1252	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GTEX-WL46-0326-SM-3LK6Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24665
GTEX-TSE9-0626-SM-3DB8B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15362
liver_d	HPA Tissue Sample Gene Expression Profiles	1.0	1.05324
bronchoalveolar system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.491791
Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q7-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K30038014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38191
Alcoholic chronic pancreatitis	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.6
GTEX-T5JW-0426-SM-4DM7M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.972648
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.824829
venous insufficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.361502
ICC108	DepMap CRISPR Gene Dependency	1.0	2.10141
DK-MG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
THG1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24965
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.867145
Myocardial infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.954
naftopidil-7331	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K56729241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42456
FAM53B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76791
BRD-K32199799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0752
Lung squamous cell carcinoma_LUSC_TCGA-77-8143-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Non-Alcoholic Fatty Liver Disease	DisGeNET Gene-Disease Associations	1.0	null
Gustatory areas, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.69616
Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)	Reactome Pathways 2014	1.0	null
BRD-K05417183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69748
pheneticillin-5763	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LU-134-A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_248_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.75948
Prostate adenocarcinoma_PRAD_TCGA-G9-7519-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NPIPA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75638
Aryl hydrocarbon receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.208
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.257
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4839-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDVN-0326-SM-2I3FS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64957
CEP97	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00766
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31451
Temporal association areas, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09134
BRD-K92571446_WZ-3105_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RPA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84749
BRD-K13390322_AT-7519_LNCAP_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cor pulmonale	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.211261
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0418
saudi	GeneRIF Biological Term Annotations	1.0	null
GTEX-XGQ4-1326-SM-4GIDU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46441
SAP30	ENCODE Transcription Factor Targets	1.0	null
SMIM24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04497
BRD-K25737009_-666_MCF7_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE234289_5_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF124	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75582
clozapine-4453	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE142210_11_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
17389037-Tab6	GeneSigDB Published Gene Signatures	1.0	null
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.56091
RCHY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60952
ovary_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.964102
BRD-K55142307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47542
BRD-A43164341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03169
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Nkx2-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.1952
JPH4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40401
BRD-K68450812	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59381
activates	GeneRIF Biological Term Annotations	1.0	null
oxoacid metabolic process	GO Biological Process Annotations 2015	1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.99
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9454
HMGN3	ENCODE Transcription Factor Targets	1.0	null
CRCGN015_MCF10A_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3653
regulation of blood circulation	GO Biological Process Annotations 2015	1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.029968
Mental Disorders	CTD Gene-Disease Associations	1.0	1.03009
PMC6932815-ppat.1007634.s011.xlsx-ST1_DGE_ELF1_lfc2_fdr05_interse-geneID_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
KDM2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67365
FAM222B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47419