association	dataset	threshold value	standardized value
BRD-K28305165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2883
JEKO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43302
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4891-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X4XY-0008-SM-46MVL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
CRCGN017_MCF10A.TP53.M_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6781
BRD-K97330035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06411
JUND_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLR20	CCLE Cell Line Gene CNV Profiles	1.0	1.39065
GSE202434,GSE202438_8_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4768-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GSE138938_1_v_2_foxp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.38705
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SA-01A-21R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
endoplasmic reticulum membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
rostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.77568
GSE143782_7_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_3_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.50715
GSE135439_0_v_1_pax5_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBEC-1526-SM-4AT68	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75056
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.60384
PMC5642521-oncotarget-08-69847-s004.xls-Sheet1-List_of_down_regulated_genes_in_NRF2_KD_A549_cells_FC_1_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:L16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0982
Ebolavirus(ZEBOV)_7day_PBMCs_rNAPc2treated_21987740_GSE24943	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-0.247756
MDAMB436	CCLE Cell Line Gene CNV Profiles	1.0	2.29215
496100556_TCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.11546
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
IA-76-ZU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271424
Ovarian Neoplasms	CTD Gene-Disease Associations	1.0	1.07305
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.74596
BRD-K09663164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67886
GTEX-SJXC-1226-SM-4DM78	GTEx Tissue Sample Gene Expression Profiles	1.0	2.09409
BRD-K80851151	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49761
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.30294
CRCGN016_MCF10A.WT.HP_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.09035
PMC4123077-cddis2014283x10.xls-Sheet1-Table_S5_Genes_upregulated_by_HAND1_in_DLD1_cells_HAND1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P4QS-0008-SM-48TDY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.956342
GSE237984_1_v_0_magi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.1911
PC3_PROSTATE	CCLE Cell Line Proteomics	1.0	4.26793
Tongue-epithelial cell	Tabula Sapiens Gene-Cell Associations	1.0	7.26887
BRD-K23817660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20531
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.1886
Prestwick-864-2994	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-OIZG-0005-SM-2HMJC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
harmalol-5076	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NR2F2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K61039403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00771
GSE206729_2_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SMC3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_11535_KD_SOX2_SRP235264	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.11537
GSE152734,GSE152735_1_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
AC-30-XU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.277947
PSI associated light-harvesting complex I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.774
HCC33	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.52005
Perturb_14479_KD_WT1_SRP337713	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.78405
BRD-K42489623_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cyproterone-3545	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nalidixic acid-4691	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ion binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-O5YW-1826-SM-2YUN2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
CRCGN011_HEPG2_24H:A12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2822
GSE109565_12_v_11_glyphosate_human	RummaGEO Drug Perturbation Signatures	1.0	null
SW948	DepMap CRISPR Gene Dependency	1.0	2.01232
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.935525
A549_UNC0379_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00984347
H3K9me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.04368
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.82476
CRCGN015_MCF10A.TP53.M_24H:P16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2042
NCIH1618	CCLE Cell Line Gene Expression Profiles	-1.0	-1.79736
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-XBEW-1326-SM-4AT63	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53492
BRD-K42499654_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC1937	CCLE Cell Line Gene CNV Profiles	1.0	1.41397
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.251934
BRD-K50240676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20215
HIV Infections	HuGE Navigator Gene-Phenotype Associations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7570-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE233049_2_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
endoplasmic reticulum	LOCATE Predicted Protein Localization Annotations	1.0	null
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.93996
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13763
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YN-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
response to stimulus	GO Biological Process Annotations 2015	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3WC-01A-31R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PLA2G2D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00438756
GSE130437_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FA-80-DR66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.76204
icSARS CoV_3Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.5954
ETV5::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8195
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46D-01A-21R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-WYJK-0326-SM-3NMA8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
gliquidone-6505	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOS	ENCODE Transcription Factor Targets	1.0	null
GTEX-S4Q7-0626-SM-4AD5M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31889
GSE48812_2_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE226285_3_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03087
GSE146982_4_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.062
PMC8582123-13073_2021_996_MOESM3_ESM.xlsx-IRF1-HIT_IRF1	Rummagene Transcription Factor Associations 2026	1.0	null
MOLT16	CCLE Cell Line Gene Expression Profiles	-1.0	-1.69361
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5462-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN013_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.08648
GTEX-PWN1-1526-SM-48TDA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37042
chr19_15935840_C_A_b38	GTEx eQTL 2025	1.0	1.24224
pentoxifylline-6021	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1MN-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K57778236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51319
GTEX-XYKS-1426-SM-4BRUO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27151
vitamin k catabolic process	GO Biological Process Annotations 2015	1.0	null
arecoline-5423	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WN-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SG in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11675
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.3453
BRD-A48913311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30525
GTEX-XBED-0008-SM-47JWO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BRD-K81418486_vorinostat_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-U4B1-0326-SM-3DB8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
inner CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.39865
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1AE-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K09414286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32505
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.015
fluticasone-4129	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
BRD-K31852848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36091
GSE205730,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LOX-1_OE_GDS4262_432_human_HAECT - aortic endothelial cell line - 2 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
liver_c	HPA Tissue Sample Gene Expression Profiles	1.0	1.27983
GTEX-Q2AH-0126-SM-48U2B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12917
PMC9643473-Table1.xls-MAF_0_005-Gene_refGeneWithVer_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65499
GSE142210_9_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_2_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H847	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889008
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.079
GSE48812_4_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
ascorbic acid-3225	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PVOW-0008-SM-48TE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BRD-K32423836	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48563
lxf289	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.93
FOS::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.5161
GTEX-QEL4-1226-SM-447A4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9177
BRD-A72180425_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC9894241-pnas.2211429119.sd05.xlsx-G6_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NFK9-1126-SM-3LK78	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15174
GTEX-OIZI-0008-SM-2XCFD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
SP in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06367
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
iocetamic acid-3022	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K86677819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37394
GTEX-RNOR-1226-SM-48FDQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14035
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO Molecular Function Annotations 2015	1.0	null
BRD-K95593113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.39628
cofactor catabolic process	GO Biological Process Annotations 2015	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5885-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55G-1626-SM-48FF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
dh15	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.155
ventral medial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16865
GSE146982_4_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.52676
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.836423
GTEX-U8XE-1726-SM-4E3IF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10704
Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)	Reactome Pathways 2014	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JO-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE193258,GSE193259_9_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
1,4-DHNA	DeepCoverMOA Drug Mechanisms of Action	1.0	1.09
Phase I - Functionalization of compounds	Reactome Pathways 2024	1.0	null
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hacat cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.573616
19061838-TableS3	GeneSigDB Published Gene Signatures	1.0	null
liver	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.83951
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CX-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cell Transformation, Neoplastic	CTD Gene-Disease Associations	1.0	1.39226
NCI-H2122 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.804
Kidney Chromophobe_KICH_TCGA-KO-8416-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LC-1F	GDSC Cell Line Gene Expression Profiles	1.0	2.10877
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.23512
CRCGN017_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.4603
BRD-K27067020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53396
RXRA	ENCODE Transcription Factor Targets	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E6-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-UJHI-0006-SM-3DB8H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00468
A549_Mesna_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126527
PMC7863452-12920_2021_883_MOESM5_ESM.xls-SRG_13_GE2-HCC_vs_17NT-GENENAME_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
Prestwick-685-4705	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SK-MEL-5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
NCIH1573	CCLE Cell Line Gene Expression Profiles	1.0	1.76606
fat-soluble vitamin metabolic process	GO Biological Process Annotations 2015	1.0	null
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.0374
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-7774-01A-21R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nitrendipine-5405	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6365-11A-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LM6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.656
carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.345558
molecular_function	GO Molecular Function Annotations 2015	1.0	null
BRD-K09919985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34404
GTEX-R55E-0006-SM-2TC5G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
hsa-miR-635	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GSE57871_6_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE125014_6_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5642521-oncotarget-08-69847-s006.xls-Sheet_1-List_of_down_regulated_genes_in_both_KEAP1_overexpression_and_NRF2_KD_A549_cells_FC_1_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7585-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Atherosclerosis	CTD Gene-Disease Associations	1.0	1.07093
PHF8-20622854-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
carbachol-3380	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K01534436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11582
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE182179_5_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K39185798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03428
GSE186471_1_v_2_carnosol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UJHI-0726-SM-3DB92	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Lung squamous cell carcinoma_LUSC_TCGA-70-6723-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymphnode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.866612
GTEX-POMQ-0626-SM-3P61E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Androgen insensitivity syndrome_Fibroblast_GSE3871	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.41852
BRD-K70843862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30081
Sarcoma_SARC_TCGA-IE-A3OV-01A-11R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226285_3_v_1_nr0b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_3920_KD_VPS37A/VPS37B_SRP266781	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.501
GSE223893_4_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.890605
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Supplementary_Table_2E_Contrast_ATF4-def_Tg_8h_vs_HCT116_Tg_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BRD-K02210445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08719
CAPAN2	CCLE Cell Line Gene CNV Profiles	1.0	1.4208
GSE146982_7_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
metanephrine-6734	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.858742
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A72E-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ibutilide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.46
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Synthesis of Leukotrienes (LT) and Eoxins (EX)	Reactome Pathways 2024	1.0	null
BRD-K67137502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15321
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JH-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
glucose metabolism disease	GWASdb SNP-Disease Associations	1.0	0.34654
FOXA1-27270436-CHIP-SEQ-PROSTATE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN008_HEPG2_24H:N08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0247
Mesothelioma_MESO_TCGA-SH-A7BD-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.28569
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I8-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
JUN_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3407-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.315
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.07482
retinoid	GeneRIF Biological Term Annotations	1.0	null
PAX5_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Cytochrome P450, E-class, group I	InterPro Predicted Protein Domain Annotations	1.0	null
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
stratum spinosum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.177529
CRCGN013_HEPG2_24H:K03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39768
oxidation-reduction process	GO Biological Process Annotations 2015	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-US-A779-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-P4PQ-0008-SM-48TDX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
16818684-Table2a	GeneSigDB Published Gene Signatures	1.0	null
GSE135352_6_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.70025
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.6308
BRD-K21000135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3218
BRD-K18178356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46258
GTEX-WFG7-2326-SM-3GIKV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978438
FOXA2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P78B-1326-SM-3P611	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08988
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE142210_11_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
coronary artery disease	GWASdb SNP-Disease Associations	1.0	0.594024
NCIH2405	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34454
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44574
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11702
GSE149035_3_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
guanfacine-5621	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOSL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.1049
PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_1_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	1.16174
Uterine Carcinosarcoma_UCS_TCGA-N7-A59B-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE199538,GSE199539_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
ABL127	DeepCoverMOA Drug Mechanisms of Action	1.0	1.14
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
esculin-5411	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_8068_KD_NONO_SRP281189	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
BRD-K15882320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33992
Brain Lower Grade Glioma_LGG_TCGA-CS-6186-01A-12R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Pracinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0118419
MYBL2	ENCODE Transcription Factor Targets	1.0	null
Respiratory epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.044
BRD-K08647020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12858
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.78338
A549_Ivosidenib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208549
BRD-K53988836	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06588
CRCGN017_MCF10A.WT.HP_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0368
GTEX-RWS6-0826-SM-47JXF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02244
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PM-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.900842
abnormality of vitamin metabolism	GWASdb SNP-Phenotype Associations	1.0	0.286704
PK1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36948
PRDM9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	176.874
GSE119978,GSE180930_2_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
regulated	GeneRIF Biological Term Annotations	1.0	null
PMC8285542-41467_2021_24656_MOESM4_ESM.xlsx-Sheet1-The_genes_positively_or_negatively_correlated_with_TP63_in_SCC_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
UACC-893	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XGQ4-0426-SM-4AT4I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08334
GTEX-S341-1226-SM-4AD5S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863388
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.81048
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.85198
vacuole-mitochondrion membrane contact site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.676
levodopa-1472	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-QVUS-0011-R1A-SM-3GAD2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07131
alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K96023136	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48406
GTEX-OXRL-0626-SM-3NM9C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05529
GTEX-PWCY-2326-SM-2I3EQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888915
BRD-K27621887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11566
PMC7617265-EMS137094-supplement-Supplementary_Tables.xlsx-ST18-gene_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PWOO-0826-SM-48TCL	GTEx Tissue Sample Gene Expression Profiles	1.0	2.38455
A549_Bisindolylmaleimide IX_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200858
orbital frontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04004
CRCGN011_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.54315
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A5W4-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pontine raphe nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.22566
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.0579
PMC10260405-41588_2023_1409_MOESM6_ESM.xlsx-ST12-Supplementary_Table_12_Most_likely_causal_genes_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
doxazosin-6642	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE146982_0_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE168797_4_v_3_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Fascia adherens	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.663
A549_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144452
PBX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100630_PCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.31742
GTEX-UJMC-1926-SM-3GADS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91064
NFYA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9109
clofazimine-5642	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18208
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUN-01A-12R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
coenzyme catabolic process	GO Biological Process Annotations 2015	1.0	null
GSE146982_4_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180468_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
rpmi8226	HPA Cell Line Gene Expression Profiles	1.0	0.885696
GTEX-X4EO-0006-SM-3P5ZF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Perturb_6687_KD_STAT3_SRP081918	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ketone catabolic process	GO Biological Process Annotations 2015	1.0	null
CRCGN015_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3656
HPX	MSigDB Cancer Gene Co-expression Modules	1.0	null
CRCGN017_MCF10A.WT.HP_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.65056
CRCGN017_MCF10A.TP53.M_24H:O09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4675
HNF4A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.96442
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3466-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior orbital gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.4483
GTEX-XUZC-1726-SM-4BRWS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BRD-K27610371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18274
Lung squamous cell carcinoma_LUSC_TCGA-79-5596-01A-31R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU2F2	JASPAR Predicted Transcription Factor Targets	1.0	null
A549_PCI-34051_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143988
levobunolol-3354	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.4459
CRCGN015_MCF10A_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10708
TC-YIK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
nervous system disease	GWASdb SNP-Disease Associations	1.0	0.059716
A498	BioGPS Cell Line Gene Expression Profiles	1.0	1.271
ARF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00397837
BRD-K67104687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99956
FE-61-DL94_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200912
bone remodeling disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.164149
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4N-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MRS 2578	DeepCoverMOA Drug Mechanisms of Action	1.0	0.89
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49583
hsa-miR-3689a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
BRD-K84586608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5808
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2950-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K40367360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55218
NCI-H661 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.848
BRD-K14653235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11606
GSE193993_0_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-W5WG-1626-SM-4LMKG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75756
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15482
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29T-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE223893_2_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UPIC-1026-SM-4IHLT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877492
BRD-K55220938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26413
PMC10859382-41392_2024_1740_MOESM3_ESM.pdf-3-KDM5B_KDM5B	Rummagene Transcription Factor Associations 2026	1.0	null
deep layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07437
BRD-K97763545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00545
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
withaferin A-4376	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A0VM-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN011_HEPG2_24H:G17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18875
GSE48812_11_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
inner portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.846113
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GR-ST	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-OHPL-0326-SM-33HC8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
NMS-873	DeepCoverMOA Drug Mechanisms of Action	1.0	1.23
CRCGN017_MCF10A.TP53.M_24H:O08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2878
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.39585
stratum pyramidale of rostral CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.974259
Alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K27me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN008_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8293
GSE195568_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-T6MO-0626-SM-4DM6P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
19168792-TableS3	GeneSigDB Published Gene Signatures	1.0	null
xenobiotic metabolic process	GO Biological Process Annotations 2015	1.0	null
H4	CCLE Cell Line Gene CNV Profiles	1.0	1.62226
Inflammation	CTD Gene-Disease Associations	1.0	1.29996
dioxybenzone-5699	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T6MN-1526-SM-4DM5P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
outer CP in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.42835
CRCGN010_HEPG2_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30026
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9534852-41598_2022_20572_MOESM4_ESM.xlsx-Sheet1-Supplementary_Table_S4_Transcriptomic_data_related_to_AHR_function_considered_for_metabolic_reconstruction_model_generation_AHR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QDVN-0008-SM-48U2D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE244710_3_v_0_srsf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S95S-0008-SM-4AT5M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE171572_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
acetaminophen_homo sapiens_gpl6244_gse27420	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
tolazoline-4262	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-XJ-A83G-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Glucose Intolerance	CTD Gene-Disease Associations	1.0	1.0561
PMC8016886-41419_2021_3630_MOESM6_ESM.xlsx-Sheet1-Table_S5_Differentially_expressed_genes_identified_between_HOXC6-low_and_HOXC6-high_expression_CRCs_using_TCGA_cohort_HOXC6	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5435-01A-01R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cardiomyoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.583
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.43005
converted	GeneRIF Biological Term Annotations	1.0	null
GSE160817_3_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CP66-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SG in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.962652
monocarboxylic acid metabolic process	GO Biological Process Annotations 2023	1.0	null
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
KU-60019	DeepCoverMOA Drug Mechanisms of Action	1.0	1.07
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Bronchial epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.941
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9117466-NIHMS1784916-supplement-Supplementary_Tables_1_to_7.xlsx-Table_3-Supplementary_Table_3_HOXB13-repressed_genes_that_were_or_were_not_rescued_by_G84E_in_Fig_1a_HOXB13	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.955085
Perturb_6799_KD_SNHG5_SRP068373	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	18.3872
BRD-A45014336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69546
17115125-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-O5YT-0008-SM-4E3IQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
NCIH292	DepMap CRISPR Gene Dependency	1.0	3.37389
GSE158975_0_v_1_spp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.125
RMUGS	CCLE Cell Line Gene Expression Profiles	1.0	1.60611
BRD-K87343552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23737
bromebric-acid	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66624
hsa-miR-146b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GSE206516,GSE206518_5_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
hek293	HPA Cell Line Gene Expression Profiles	-1.0	-0.969415
chr19_15900332_T_C_b38	GTEx eQTL 2025	1.0	4.16585
cation binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-UJHI-0126-SM-4IHLP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE229973_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
octopamine-6491	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mephenesin-4698	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cyp4f11	GeneRIF Biological Term Annotations	1.0	null
GTEX-U3ZH-0008-SM-4DXT2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Brain Lower Grade Glioma_LGG_TCGA-DB-A64O-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A39996500_radicicol_MCF7_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7407-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K28057105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05878
A549_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191828
COPS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15546
BRD-K98264372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37227
GTEX-T5JC-0008-SM-4DM6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
PAX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A6BA-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EVI1-22308434-SKOV3-HUMAN-OVARY-OVARIANCANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.63709
GSE48812_2_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81782447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24855
vitamin metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-OHPN-2926-SM-3LK65	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09367
GTEX-QDVN-0326-SM-2I3FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE80098,GSE80366_0_v_8_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.388001
CGTHW1	CCLE Cell Line Gene CNV Profiles	1.0	2.69168
5213008-898	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE206984_1_v_0_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_INO-1001_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133888
Pitolisant	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
GTEX-Q2AI-0626-SM-48TZU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1308
OVOL2_01_313	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.95337
icSARS CoV_12Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-0.678901
Lung adenocarcinoma_LUAD_TCGA-64-5781-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
septal nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.832761
Liver hepatocellular carcinoma_LIHC_TCGA-LG-A6GG-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
estradiol_homo sapiens_gpl571_gds4052	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
496100375_FWM_dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.34478
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEG01	CCLE Cell Line Gene CNV Profiles	1.0	1.36071
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25388
BRD-K33583600_ISOLIQUIRITIGENIN_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE155972_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE221327_1_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-4650-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GTEX-S4UY-0006-SM-3K2A7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BRD-K35171408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33999
GTEX-WHSE-0926-SM-3NMBS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE146982_7_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN014_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.93228
8305C	CCLE Cell Line Gene CNV Profiles	-1.0	-2.13759
GTEX-U3ZN-0008-SM-4DXTL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BRD-K07667918_linsitinib_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K39400123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7599
had	GeneRIF Biological Term Annotations	1.0	null
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-XUW1-1026-SM-4BONY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.985284
GSE118490_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF263	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.5566
GSE223908,GSE223909_4_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZFP14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	144.9
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
molsidomine-5426	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOS::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.8139
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)	Reactome Pathways 2014	1.0	null
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260184
NCIH727	CCLE Cell Line Gene CNV Profiles	1.0	1.59672
PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
long-chain fatty acid omega-hydroxylase activity	GO Molecular Function Annotations 2025	1.0	null
GSE214931_4_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PK59	CCLE Cell Line Gene CNV Profiles	1.0	1.91644
isradipine-6508	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H460 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.031
heart_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
Rectum adenocarcinoma_READ_TCGA-G5-6572-02A-12R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZSCAN31	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.8059
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5811
GSE142210_9_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ketone catabolic process	GO Biological Process Annotations 2025	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	1.7544
20-Hydroxy-leukotriene B4	HMDB Metabolites of Enzymes	1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.900842
Brain Lower Grade Glioma_LGG_TCGA-HT-7860-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100354_PCx_dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.15054
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.8232
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
BRD-K41141507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.73048
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.58203
NCIH1793	CCLE Cell Line Gene Expression Profiles	1.0	2.26618
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14443
BRD-K39176069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25403
NFIC_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-5629-01A-01R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K03383196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48565
Lung adenocarcinoma_LUAD_TCGA-78-7220-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3620	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
single-organism catabolic process	GO Biological Process Annotations 2015	1.0	null
TST	MSigDB Cancer Gene Co-expression Modules	1.0	null
Hyperglycemia	HuGE Navigator Gene-Phenotype Associations	1.0	null
benfotiamine-3931	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5550886-cddis2017345x3.xlsx-siRAD21_DEGs_NOT_rescued_by_Myc-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146982_3_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
sulpiride-4566	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U8T8-0008-SM-4DXSP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
10-methoxyharmalan-5455	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Autosomal recessive congenital ichthyosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.256
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-19q13_43_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K96567801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.63543
HCC1500	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.80912
FA-63-WI26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.351874
Endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
A549_MLN8054_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130384
KMS-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.835512
A-Netherlands-602-2009(H1N1)_7Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.28731
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09568
Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)	Reactome Pathways 2014	1.0	null
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	GO Molecular Function Annotations 2023	1.0	null
GTEX-SIU7-1826-SM-2XCE2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE146982_4_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Fumagillin	DeepCoverMOA Drug Mechanisms of Action	1.0	0.31
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.4608
CRCGN011_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.01095
BRD-K37637965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26391
piperacillin-3939	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
membrane part	GO Cellular Component Annotations 2015	1.0	null
A549_Cediranib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00940315
Lung squamous cell carcinoma_LUSC_TCGA-22-5479-01A-31R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.847895
LC1SQSF	CCLE Cell Line Gene Expression Profiles	1.0	1.79517
Radicicol	DeepCoverMOA Drug Mechanisms of Action	1.0	1.59
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3698
GTEX-PX3G-0326-SM-2I3EO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE48812_3_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K61718261_NCGC00182361-01_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
methazolamide-2733	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WYJK-0126-SM-3NMAB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
TNP-470	DeepCoverMOA Drug Mechanisms of Action	1.0	1.66
zona incerta, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.843331
BRD-K63163033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07288
BRD-K50941255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59518
PNU-0251126-4714	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A551-01A-21R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF4	ChEA Transcription Factor Targets	1.0	null
BRD-K75263760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10866
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.1197
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09505
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Synthesis of Leukotrienes (LT) and Eoxins (EX)	Reactome Pathways 2014	1.0	null
lung cancer	GAD Gene-Disease Associations	1.0	null
smooth muscle	HPA Tissue Gene Expression Profiles	-1.0	-0.84354
BXPC-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC8143797-elife-62857-fig3-data2.xlsx-DEgenes_SW872_TAZ-CAMTA1_vs_EV-Gene_CAMTA1	Rummagene Transcription Factor Associations 2026	1.0	null
GATA3-21878914-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TE-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K75413392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45218
GTEX-POYW-0008-SM-48TE4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE146982_0_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K77024507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16864
GTEX-WFJO-1026-SM-3GIKL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.961526
BRD-K73780763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0724
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224467
BRD-K52194153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50704
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.138
GSE235701,GSE261434_2_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IRF4	ENCODE Transcription Factor Targets	1.0	null
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
omegahydroxylation	GeneRIF Biological Term Annotations	1.0	null
GSE160817_4_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202825_2_v_1_ano1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:O20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37158
endoplasmic reticulum part	GO Cellular Component Annotations 2015	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A8RZ-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
large intestine	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135629
SNU1076	DepMap CRISPR Gene Dependency	1.0	4.05819
GTEX-XLM4-0008-SM-4AT4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Metapathway biotransformation(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
GTEX-U8XE-0005-SM-3DB8I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
A549_Celecoxib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187643
enzalutamide_homo sapiens_gpl570_gse44905	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE184087_4_v_1_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PRC_DEPLETION_GDS3532_96_human_U2OS cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE175787_11_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.359
CRCGN017_MCF10A.TP53.M_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.68915
BRD-K77797589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19151
GTEX-OOBK-2626-SM-2HMKY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33663
hsa-miR-4314	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Perturb_6761_KD_VPS4A/VPS4B_SRP187973	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.51786
hsa-miR-4264	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
H3K27me3_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU308	DepMap CRISPR Gene Dependency	1.0	2.00285
CHPF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99921
Lung squamous cell carcinoma_LUSC_TCGA-56-A4BY-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K72034681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53779
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9562
Lung squamous cell carcinoma_LUSC_TCGA-MF-A522-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S7SE-0826-SM-4AT4D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BRD-K13196166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17009
GSE151083_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
josamycin-5692	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PBX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCOR-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
HCT116	BioGPS Cell Line Gene Expression Profiles	1.0	1.10412
SKMEL2	DepMap CRISPR Gene Dependency	1.0	2.22851
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S33H-1626-SM-4AD68	GTEx Tissue Sample Gene Expression Profiles	1.0	2.00438
GTEX-WFJO-0326-SM-3GIL3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A5SP-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K72700187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38444
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E0-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-69-A59K-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5ML-01A-31R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8062-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K89224880_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NB1643	DepMap CRISPR Gene Dependency	1.0	3.88344
BRD-K92317137_-666_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE57871_6_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EKVX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.890605
496100372_HIP_dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.04663
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.92684
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Lung squamous cell carcinoma_LUSC_TCGA-56-7582-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T6MN-0126-SM-32PLP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BRD-K15975627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27147
BRD-K07525144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27923
pathways	GeneRIF Biological Term Annotations	1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221943
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7926-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
efo21	HPA Cell Line Gene Expression Profiles	1.0	1.13728
SKHEP1	DepMap CRISPR Gene Dependency	1.0	2.73857
hsa-miR-374a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GTEX-TKQ2-1326-SM-4DXT9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
CRCGN015_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.8979
multicellular organismal process	GO Biological Process Annotations 2015	1.0	null
Perturb_2815_KD_LSD1_SRP310243	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE230573_1_v_0_dcaf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211151_2_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
central nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.69494
bladder	GTEx Tissue Gene Expression Profiles	1.0	0.887852
PMC9894241-pnas.2211429119.sd05.xlsx-G1_REST-Dataset_S5_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
GSE197571_2_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A36275421_MW-ras12_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TAL1-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
motor nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.945019
BRD-A95970093	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17467
UterusCorpus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.5279
PMC10534007-Table_2.xlsx-S3_unique_up_MSC_V-817_elements_included_exclusively_in_VM-CUB1_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WFJO-0626-SM-4LVMC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-R55E-0008-SM-48FCG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
SIX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5052
medial preoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28542
Lung adenocarcinoma_LUAD_TCGA-55-6972-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
k562	HPA Cell Line Gene Expression Profiles	-1.0	-0.969415
BRD-K77978259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5351
SG in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20323
PMC12882559-12894_2026_2046_MOESM2_ESM.docx-0-ZNF770_ZNF770	Rummagene Transcription Factor Associations 2026	1.0	null
benzathine benzylpenicillin-4140	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
USF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN017_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.00347
GTEX-PWN1-0008-SM-48TEA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.92049
GTEX-R55G-1226-SM-48FDC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98545
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-A06929388_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100334_PCx_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.01029
GTEX-NFK9-0008-SM-4E3JE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-N7MT-0326-SM-48TDP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17984
BRD-K38710631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9352
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A42Q-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A_48H:H23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.10471
fatty acid omega-hydroxylase activity	GO Molecular Function Annotations 2023	1.0	null
PMC12331601-Table2.xlsx-KD_vs_CON-Gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Thiamet G	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.36
long-chain fatty acid omega-hydroxylase activity	GO Molecular Function Annotations 2023	1.0	null
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.48
SIX5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ2-0826-SM-33HB6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	1.0	2.21789
AC-30-XU83_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.697048
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K95577144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10172
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
SIX5	ENCODE Transcription Factor Targets	1.0	null
NCI-H1573	GDSC Cell Line Gene Expression Profiles	1.0	2.28498
SIX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.956342
MI-773	DeepCoverMOA Drug Mechanisms of Action	1.0	1.7
GSE154197_1_v_2_ints13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205332_1_v_0_queuine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.6614
CTV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCIH2122	CCLE Cell Line Gene Expression Profiles	1.0	2.18007
membrane region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.007697
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064332
AB-09-EA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.918549
TDRD3-21172665-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
oxantel-6738	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
facial motor nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01632
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
ASPIRIN	DGIdb Drug Targets 2026	1.0	1.203
Lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
pizotifen-6513	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XUZC-0526-SM-4BOPF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Miscellaneous substrates	Reactome Pathways 2014	1.0	null
hsa-miR-1179	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
PAX5_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Thymus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.16314
CD8+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.20099
EBF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE230744,GSE237803_0_v_2_hira_human	RummaGEO Gene Perturbation Signatures	1.0	null
OVCAR433	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.956342
spinal (inferior) vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.13011
PMC4498179-srep11671-s1.pdf-117-ZNF99_ZNF99	Rummagene Transcription Factor Associations 2026	1.0	null
HNF4A	ENCODE Transcription Factor Targets	1.0	null
F0447-0125-6424	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-374b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
phylloquinone catabolic process	GO Biological Process Annotations 2025	1.0	null
A549_Ofloxacin_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0119102
SIN3A	ENCODE Transcription Factor Targets	1.0	null
posteroventral (inferior) parietal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.13963
hsa-miR-891b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
dobutamine-5386	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RFX5	ENCODE Transcription Factor Targets	1.0	null
TPPB	DeepCoverMOA Drug Mechanisms of Action	1.0	0.96
CRCGN010_HEPG2_24H:C02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0869
lipid metabolic process	GO Biological Process Annotations 2025	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20U-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A5Y0-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K38345640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09394
regulation of biological quality	GO Biological Process Annotations 2015	1.0	null
GABPA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
unsaturated fatty acid metabolic process	GO Biological Process Annotations 2025	1.0	null
GSE182179_5_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.1781
MG63	CCLE Cell Line Gene CNV Profiles	1.0	1.63073
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.900842
cefazolin-2564	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BRD-K64531971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01584
Perturb_3778_KD_JAK2_SRP041162	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K42697646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36786
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Fatty acids	Reactome Pathways 2024	1.0	null
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04687
CRCGN017_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.80515
primary auditory cortex (core)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.915782
iohexol-3322	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
gallbladder_5a	HPA Tissue Sample Gene Expression Profiles	1.0	0.840756
BRD-K74600148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98082
CRCGN017_MCF10A.WT.HP_24H:J04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43498
SG in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.867267
Daphnid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.66
CRCGN015_HEPG2_48H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6515
Perturb_3978_KD_KAT5_SRP128080	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.7466
BRD-K16641781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28267
BRD-K70940767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0717
hsa-miR-720	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
PMC10713402-aging-15-205220-s005.docx-0-RBAK_RBAK	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146982_3_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BCL11A	ENCODE Transcription Factor Targets	1.0	null
GTEX-T2IS-0926-SM-4DM5B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE146982_4_v_2_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4303	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RTLS-2626-SM-46MUJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18077
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20U-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WYJK-1726-SM-3NM9U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Sulcotrione	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.22
BRD-K34737616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48955
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27ac_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC5105166-ncomms13331-s11.xlsx-Sheet1-Supplementary_Data_10_Overlap_of_upregulated_genes_in_MEF2D-rearranged_cases_with_public_ChIPseq_RNAseq_data_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
interpeduncular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.70966
GSE119978,GSE180930_6_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Buccal epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.97
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.1763
CHLA266	DepMap CRISPR Gene Dependency	1.0	4.31392
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039567
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.941142
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044713
Intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K13086002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59507
GSE142210_11_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GATA3-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN017_MCF10A.TP53.M_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22946
TestisGermCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.878521
CRCGN008_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.12565
H3K4me1_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2937-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K45062933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2432
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BRD-K88620071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09265
H3K4me3_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-P4QT-1426-SM-3NMCX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.899204
CRCGN015_MCF10A.WT.HP_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.9642
GTEX-T5JC-1826-SM-4DM6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
MYC_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A39660642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17971
ARID3A	ENCODE Transcription Factor Targets	1.0	null
atherosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.273815
Gastroesophageal junction	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.577
GTEX-XBED-1926-SM-47JYP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
outer SZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.95974
BRD-K91962463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78432
lateral tuberal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.30853
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5556
Sarcoma_SARC_TCGA-3B-A9HQ-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.77482
GSE140651,GSE140653_2_v_0_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K03309398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07784
ESRRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2479
Sickle Cell Anemia_Endothelial cell_GSE9877	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.2736
GSE146982_3_v_2_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
myricetin-3270	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7608835-aba3058_Table_S5.xlsx-RING1B_EWS-FLI1_REPRESSED-RING1B_EWSR1-FLI1_repressed_genes_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.11012
GTEX-XBEW-0008-SM-4AT3Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
ebselen-3458	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6VB-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MM370	DepMap CRISPR Gene Dependency	1.0	3.7467
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29217
Acute Myeloid Leukemia_LAML_TCGA-AB-2999-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
single-organism process	GO Biological Process Annotations 2015	1.0	null
GTEX-PW2O-0008-SM-48TEB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE156454_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE214931_2_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.85155
Perturb_10387_OE_DRP1_SRP333953	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_383_KD_NFE2L2_SRP158498	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.8345
BRD-K37379978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21188
MCC26	COSMIC Cell Line Gene Mutation Profiles	1.0	null
chr19_15934681_G_C_b38	GTEx eQTL 2025	1.0	5.11554
nocodazole-2076	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Fatty Liver	CTD Gene-Disease Associations	1.0	1.19213
flucloxacillin-6507	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39X-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
QC-76-GI57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.438178
PAX5	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SNMC-0826-SM-4DM66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35494
Lung adenocarcinoma_LUAD_TCGA-75-7027-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE48812_0_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
20035825-TableS7b	GeneSigDB Published Gene Signatures	1.0	null
fat-soluble vitamin catabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K71615409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70492
VMCUB1	CCLE Cell Line Gene Expression Profiles	1.0	1.63211
CRCGN009_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36964
SNU503	CCLE Cell Line Gene Expression Profiles	1.0	3.09622
cyp4f12	GeneRIF Biological Term Annotations	1.0	null
OCIM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38979
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-3192	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
caudal subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34891
BRD-K93956318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16379
PANC0327	CCLE Cell Line Gene CNV Profiles	1.0	1.46449
GABPA	ENCODE Transcription Factor Targets	1.0	null
Type 1 diabetes mellitus_Thymic epithelial cell_GSE11	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.11624
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4817-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1428	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.5269
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.04485
BATF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
chr19_15912306_C_T_b38	GTEx eQTL 2025	1.0	5.35014
PDE-9i	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.43
cell part	GO Cellular Component Annotations 2015	1.0	null
MLN4924	DeepCoverMOA Drug Mechanisms of Action	1.0	1.85
15-delta prostaglandin J2-6948	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE114284_4_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDVN-0826-SM-48TZ2	GTEx Tissue Sample Gene Expression Profiles	1.0	2.28019
WNT1	MSigDB Cancer Gene Co-expression Modules	1.0	null
MCF7_BREAST	CCLE Cell Line Proteomics	1.0	6.76814
BRD-K57404319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10939
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN011_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.39425
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18272
BRD-A63590986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33519
CRCGN009_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32421
globus pallidus, internal segment, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.31936
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
GSE223893_1_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2226
BRD-K31977946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.35357
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
CCL7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00485042
levodopa-4394	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mephenytoin-3580	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Hyperplasia	CTD Gene-Disease Associations	1.0	1.04389
A549_Prednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162613
TBCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15795
HNF4G_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bed  nucleus of stria terminalis, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.4011
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
abnormalities of the peripheral arteries	GWASdb SNP-Phenotype Associations	1.0	0.215286
17699775-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
CTB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RB1_KD_GSE50532_660_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
TP53	JASPAR Predicted Transcription Factor Targets	1.0	null
Perturb_6720_KO_KDM3A_SRP128505	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
phylloquinone metabolic process	GO Biological Process Annotations 2023	1.0	null
496100545_HIP_possible Alzheimer's disease_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.32387
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Cerebrocostomandibular syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.113
GTEX-WH7G-0926-SM-4LVMJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99461
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26701
CRCGN015_MCF10A.WT.HP_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40439
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
A549_SRT3025 HCl_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0119129
Bietti crystalline corneoretinal dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.663
CRCGN015_MCF10A.WT.HP_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0438
Uterine Cervical Neoplasms	CTD Gene-Disease Associations	1.0	1.10388
Rectum adenocarcinoma_READ_TCGA-CL-5917-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K9me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K40917447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32583
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Down_bins-Down_bins_loosing_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-8258-11A-01R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KATO III	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.96779
Perturb_6295_KO_KRT17_SRP314436	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
plhc-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.56603
CRCGN011_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.81475
monooxygenase activity	GO Molecular Function Annotations 2015	1.0	null
IALM_LUNG	CCLE Cell Line Proteomics	1.0	4.42881
A549_SRT1720 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138276
NCI-H2087	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A72U-01A-31R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-A20731954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70387
BRD-K10325583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63059
layer III of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.829646
BRD-K73802986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56198
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
CRCGN008_HEPG2_24H:K04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59125
MYC	ENCODE Transcription Factor Targets	1.0	null
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49583
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
disease	GWASdb SNP-Disease Associations	1.0	0.04698
SF539	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.11353
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:I15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0255
GTEX-S95S-1426-SM-2XCDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
PMC5703746-Table1.XLSX-ST6_MAF-GENE_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U412-0526-SM-3DB9I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
AB-18-YN11_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.61899
A549_Rucaparib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176867
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
JAK2_knockout_79_GSE26188	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.65306
GTEX-QDVJ-1426-SM-48U1Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03627
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SYK_KD_GDS3609_441_human_MCF10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Azilsartan	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.28
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.60593
BCL6-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K51446586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30242
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-SNOS-0008-SM-4DM6I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JX-A3Q0-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pirlindole-6519	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
multiple	GeneRIF Biological Term Annotations	1.0	null
OccipitalLobe	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.942506
icSARA deltaORF6_3Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.92262
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.051988
BRD-K50477983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06512
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
dentate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06571
BRD-K83874987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05961
BRD-K02301426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87272
H3K4me1_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
496100496_FWM_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.41592
CRCGN016_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.14246
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44138
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.243
glipizide-4991	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN014_HEPG2_24H:L17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09564
NCIH82	DepMap CRISPR Gene Dependency	1.0	4.02582
layer VI of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19395
central nervous system disease	GWASdb SNP-Disease Associations	1.0	0.116716
BRD-K64509887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1948
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
tanespimycin-5914	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K91189798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17523
GSE48812_9_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hepatopancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.682
THAP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.7935
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-VJYA-0726-SM-4KL1T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13817
BRD-K77207661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14578
riluzole-4689	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-UJHI-0926-SM-4IHKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BRD-K10459843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54037
GSE121866_1_v_3_six4_human	RummaGEO Gene Perturbation Signatures	1.0	null
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
NCIH196	CCLE Cell Line Gene CNV Profiles	1.0	2.83611
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
osteoporosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.213959
GSE57871_5_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XMK1-1326-SM-4B65Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.995977
MZ in dorsomedial parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.950384
H3K27ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NADPH	HMDB Metabolites of Enzymes	1.0	null
PMC6347838-13046_2019_1042_MOESM3_ESM.xls-PRDM16_group_peak_anno-Gene_PRDM16	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171572_5_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
azathioprine-5262	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Oxidation by Cytochrome P450(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_1h-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
C84	DepMap CRISPR Gene Dependency	1.0	3.55232
Lung adenocarcinoma_LUAD_TCGA-35-3615-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7923-01A-12R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6727_KD_VPS4A/VPS4B_SRP187973	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.40823
MBD4	ENCODE Transcription Factor Targets	1.0	null
HN	CCLE Cell Line Gene CNV Profiles	1.0	2.25428
ZBTB33_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE233647_4_v_6_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.19545
BRD-K86721033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20661
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE245778_1_v_0_runx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cefotaxime-2235	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
menaquinone4	GeneRIF Biological Term Annotations	1.0	null
GSE146612_2_v_0_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NALM-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ROS50	DepMap CRISPR Gene Dependency	1.0	2.06484
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
CRCGN016_MCF10A.WT.HP_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.64568
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRK-0008-SM-3NB28	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
AA-18-GQ83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24793
SP1	ENCODE Transcription Factor Targets	1.0	null
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
EP300_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11983
ETK-1	GDSC Cell Line Gene Expression Profiles	1.0	1.90652
BRD-K99462197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06558
STAT5A	ChEA Transcription Factor Targets	1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE48812_9_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BACH1	ChEA Transcription Factor Targets	1.0	null
carbohydrate metabolism disease	GWASdb SNP-Disease Associations	1.0	0.34654
BRD-K01240438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15653
Acute Myeloid Leukemia_LAML_TCGA-AB-2897-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.134
M14	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18686
GTEX-O5YV-0008-SM-4E3HP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Perturb_7941_KO_MED12_SRP201365	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.43719
GTEX-U3ZH-1126-SM-4DXUG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.646074
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.652589
hsa-miR-620	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE221327_1_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
sulfapyridine-6101	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN012_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.48836
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.73767
Sarcoma_SARC_TCGA-PC-A5DL-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
genotype	GeneRIF Biological Term Annotations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7210-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
estradiol_homo sapiens_gpl6947_gse27375	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE149901_2_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04687
Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z2-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAOV-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08241
hsa-miR-2467-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GTEX-QDVN-1026-SM-48TZA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10151
GTEX-XV7Q-1026-SM-4BRVR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
A549_Cimetidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0230068
BRD-K89216747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07201
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH322	CCLE Cell Line Gene Expression Profiles	1.0	1.37559
YY1	ENCODE Transcription Factor Targets	1.0	null
GTEX-U8XE-0008-SM-4E3K4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BRD-K67716105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10834
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.924376
JUN	ENCODE Transcription Factor Targets	1.0	null
epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068445
BRD-K14416602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01287
EW-7	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XYKS-0226-SM-4BRW3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Sarcoma_SARC_TCGA-SI-A71P-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer V of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.929953
MLS0315771	DeepCoverMOA Drug Mechanisms of Action	1.0	0.34
GTEX-U3ZN-0226-SM-3DB8D	GTEx Tissue Sample Gene Expression Profiles	1.0	2.1128
neurodegenerative disease	GWASdb SNP-Disease Associations	1.0	0.313573
CRCGN016_MCF10A.TP53.M_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.00545
disease of cellular proliferation	GWASdb SNP-Disease Associations	1.0	0.048446
FOXH1-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7437-01A-21R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OSR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.4198
Perturb_6609_KO_STK11|KEAP1_ERP124775	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-6592-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dimethadione-3367	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H2023	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.9185
d446n	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-3922-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
NCIH929	CCLE Cell Line Gene Expression Profiles	-1.0	-1.5446
P31FUJ	DepMap CRISPR Gene Dependency	1.0	3.71981
GTEX-UJHI-1226-SM-4IHLR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
HOXC6_01_333	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.69067
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-VB-A8QN-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
cancer	GAD High Level Gene-Disease Associations	1.0	0.293278
interstitial nucleus of Cajal, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.961705
etamsylate-4399	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
liver	GeneRIF Biological Term Annotations	1.0	null
MM1S	DepMap CRISPR Gene Dependency	1.0	2.76565
CRCGN013_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.00544
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.5014
HS936T	DepMap CRISPR Gene Dependency	1.0	2.48171
KLM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.69813
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-UJHI-1526-SM-3DB99	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE203485_1_v_0_zdhhc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_3_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nutrition disease	GWASdb SNP-Disease Associations	1.0	0.388325
EP300_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)	Reactome Pathways 2014	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A299-01A-21R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
basolateral nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.844722
etofenamate-7327	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ESR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.5088
POU2F2_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92383
BRD-K42455570_NCGC00182380-01_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SISO	DepMap CRISPR Gene Dependency	1.0	2.08127
GTEX-Q2AG-1126-SM-48U1P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77739
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KD-11A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE238116_1_v_0_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144731
GTEX-X585-1226-SM-46MW7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13789
phylloquinone catabolic process	GO Biological Process Annotations 2023	1.0	null
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6786
PMC7495487-41598_2020_71030_MOESM2_ESM.xlsx-Sheet1-NR1A1_THRA	Rummagene Transcription Factor Associations 2026	1.0	null
Hepa-RG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.799
RXRA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU245	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34153
GA-87-BR97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.641967
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.34051
KYSE270	DepMap CRISPR Gene Dependency	1.0	4.13014
terguride-5400	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC4975902-12864_2016_2842_MOESM12_ESM.xlsx-targets_of_IRF8_in_NSCLC-COX7C_IRF8	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20O-01A-21R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
TCC-SUP cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.167
Prostate adenocarcinoma_PRAD_TCGA-J9-A8CN-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAP3K14	MSigDB Cancer Gene Co-expression Modules	1.0	null
GSE191015_1_v_2_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-UTHO-0008-SM-4JBID	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
A549_XAV-939_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177671
CRCGN012_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.51834
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058054
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
NCI-H1944	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.905244
CRCGN013_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.54583
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.124
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A71E-01A-31R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAKI2	DepMap CRISPR Gene Dependency	1.0	4.07328
BRD-K18865369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62131
GSE146982_0_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPK5-1526-SM-4JBJA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830115
BRD-K11016405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66923
Sarcoma_SARC_TCGA-DX-A3U8-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferior olive, dorsal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3013
Perturb_14362_KD_SORBS2_SRP112756	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.92906
GSE166783_0_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VZ in rostral cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04289
Lung Neoplasms	CTD Gene-Disease Associations	1.0	1.23042
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
CRCGN016_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.25898
sulfadoxine-3547	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K83708628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22646
GSE204929_0_v_1_ywhag_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K52261313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45574
CRCGN017_MCF10A.TP53.M_24H:J04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39878
inferior frontal gyrus, triangular part, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07125
Lung adenocarcinoma_LUAD_TCGA-62-8398-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4311	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Defective MAOA causes Brunner syndrome (BRUNS)	Reactome Pathways 2014	1.0	null
GSE226584,GSE226589_1_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00773
NCI-H358	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-A82394575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30837
PANC 03.27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.2348
GTEX-OHPL-0008-SM-4E3I9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BACH1-22875853-HELA-AND-SCP4-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
a431	HPA Cell Line Gene Expression Profiles	1.0	0.871153
capan2	HPA Cell Line Gene Expression Profiles	1.0	1.64353
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11863
GSE160817_7_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.938562
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Lung adenocarcinoma_LUAD_TCGA-78-7154-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A23345137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11186
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z6-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.373552
WDR75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22282
MDAMB415	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.657141
MERO25	DepMap CRISPR Gene Dependency	1.0	2.74683
mebhydrolin-4211	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69874
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1155 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.27
H3K4me1_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Neurokinin A	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.46
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.24
Kidney Chromophobe_KICH_TCGA-KM-8476-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Esophageal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.668
GTEX-XMK1-1726-SM-4B64Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825709
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
XD-08-ZW85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.526351
BRD-K28753508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54835
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.344
A549_PJ34_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134286
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN012_HEPG2_24H:N19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30649
JUND_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A4XI-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Leukotriene B4	HMDB Metabolites of Enzymes	1.0	null
NCVADR RES	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.04475
POT1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4216
H3K4me1_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN013_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55238
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WH7G-0008-SM-4LVNM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
overnutrition	GWASdb SNP-Disease Associations	1.0	0.454373
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.677009
FOXA2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Becker	GDSC Cell Line Gene Expression Profiles	-1.0	-1.46286
GTEX-RWSA-2026-SM-47JX8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91122
Perturb_6752_KD_VPS4A/VPS4B_SRP187973	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.26447
H3K27me3_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NB5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K07812227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12326
GSE130396_1_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POU2F2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RTLS-0426-SM-2TF5K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853527
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39574
GTEX-OIZG-1026-SM-3LK5X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15506
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	3.26196
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Stomach smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.925
MZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.3821
GTEX-QLQ7-0826-SM-447B3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0663
Uterine Carcinosarcoma_UCS_TCGA-ND-A4WA-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-UPIC-0926-SM-4IHLV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88542
catalyzed	GeneRIF Biological Term Annotations	1.0	null
Perturb_8071_KD_SFPQ_SRP281189	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Bronchial mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.64
HT-1376 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.869
cephalothin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7044
globus pallidus, external segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.930727
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
HCT15	BioGPS Cell Line Gene Expression Profiles	1.0	0.982142
GTEX-PSDG-0008-SM-48TE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5440-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-18a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE180468_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K84233319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45156
endoplasmic reticulum membrane	GO Cellular Component Annotations 2015	1.0	null
GSE79572_0_v_1_pax8_human	RummaGEO Gene Perturbation Signatures	1.0	null
negligible	GeneRIF Biological Term Annotations	1.0	null
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221099
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.837336
A549	GDSC Cell Line Gene Expression Profiles	1.0	1.68494
hsa-miR-769-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
BRD-K07979116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31559
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14867
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A852-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K17889110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29585
Lung squamous cell carcinoma_LUSC_TCGA-77-6843-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STK066844	DeepCoverMOA Drug Mechanisms of Action	1.0	0.55
GSE175787_13_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE241108_1_v_0_sulfasalazine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Miscellaneous substrates	Reactome Pathways 2024	1.0	null
smallintestine_4c	HPA Tissue Sample Gene Expression Profiles	1.0	1.03068
BRD-K78222058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08491
BRD-K51454545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29295
Oligospermia	CTD Gene-Disease Associations	1.0	1.07376
BATF	ENCODE Transcription Factor Targets	1.0	null
BT12	DepMap CRISPR Gene Dependency	1.0	2.47093
NR6A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5149
GTEX-NL3H-0008-SM-4E3HU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
CRCGN016_MCF10A.TP53.M_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77697
GSE163240_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A550-01A-61R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gdm1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.711
PMC5741248__F10	PFOCR Pathway Figure Associations 2024	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039633
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27151
PXR (PXR:RXR)	MotifMap Predicted Transcription Factor Targets	1.0	null
central gray substance of midbrain, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.861195
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE137702_2_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CFPAC1	DepMap CRISPR Gene Dependency	1.0	2.21497
MBD4_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mesothelioma_MESO_TCGA-SC-A6LQ-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-UPK5-1226-SM-4IHL8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08958
BRD-K06250424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36521
unsaturated fatty acid metabolic process	GO Biological Process Annotations 2023	1.0	null
icosanoid metabolic process	GO Biological Process Annotations 2023	1.0	null
BRD-K86472598_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZXDC1_KD_GSE45417_686_human_U937	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K84199148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47995
DA-27-BW40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220288
ventrolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.936805
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.687454
tobacco use disorder	GAD Gene-Disease Associations	1.0	null
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
H3K9me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.338
ZNF213	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.1674
KYSE70	CCLE Cell Line Gene Expression Profiles	1.0	1.54426
UMC-11	GDSC Cell Line Gene Expression Profiles	1.0	1.77675
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
organic substance catabolic process	GO Biological Process Annotations 2015	1.0	null
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.86449
BRD-K24132293_piperlongumine (HPLC)_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.3597
BRD-A68526335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11514
cyp4f2	GeneRIF Biological Term Annotations	1.0	null
PMC7726486-mmc3.xlsx-Sheet1-Table_S2_Differentially_expressed_genes_in_ZFP-VPR-362_samples_ZKSCAN7	Rummagene Transcription Factor Associations 2026	1.0	null
FOXA2	ENCODE Transcription Factor Targets	1.0	null
5211181-834	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE238018_1_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
nucleus accumbens, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.88084
BRD-K06619604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46743
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.372
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.141
EP300_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hep-g2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.824431
IM95	DepMap CRISPR Gene Dependency	1.0	3.37837
Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)	Reactome Pathways 2014	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7517
iocetamic acid-4425	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
prdm1_21670299_e18dot5_small_intestine_lof_mouse_gpl6887_gse29658	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.370694
GTEX-PLZ5-1126-SM-3P613	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834655
SP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.84437
HCC1428	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35792
Perturb_506_OE_GPD1_SRP252809	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
BRD-K95343362	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22896
Perturb_7939_KO_MED12_SRP201365	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.15672
cyp4f3b	GeneRIF Biological Term Annotations	1.0	null
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWS6-0008-SM-47JYV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
H3K4me1_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-REY6-1226-SM-48FDR	GTEx Tissue Sample Gene Expression Profiles	1.0	2.31485
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Bisindolylmaleimide IX_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0115008
Perturb_3921_KD_VPS37A/VPS37B/VPS37C_SRP266781	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	18.0809
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
T3M10	CCLE Cell Line Gene CNV Profiles	1.0	1.4405
C2BBE1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.361
CTCF	ENCODE Transcription Factor Targets	1.0	null
spinal trigeminal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.850048
GTEX-NFK9-1226-SM-3LK79	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE222758_0_v_3_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X5EB-0626-SM-46MVQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
KATOIII	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57013
Perturb_7726_KO_MED12_SRP201365	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.34404
bounding membrane of organelle	GO Cellular Component Annotations 2015	1.0	null
Endoplasmic reticulum subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0247
correlated	GeneRIF Biological Term Annotations	1.0	null
GTEX-OHPK-1326-SM-3MJGN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03363
intestine	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Prostate adenocarcinoma_PRAD_TCGA-J9-A8CL-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K75360899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29909
HNF4A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K53326976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83974
Metabolism	Reactome Pathways 2014	1.0	null
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5004
hepatoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.123243
EWSR1-FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	132.171
Her2_OE_GSE43730_683_human_MCF10A cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-NFE2L2_V2-Ensemble_gene_ID_NFE2L2	Rummagene Transcription Factor Associations 2026	1.0	null
KCL22	DepMap CRISPR Gene Dependency	1.0	3.42353
HPGDS-In1	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.28
BRD-K32522318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78458
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.23456
CHD2	ENCODE Transcription Factor Targets	1.0	null
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
CRCGN013_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.43807
PMC5865663-oncotarget-09-14193-s002.docx-0-Supplementary_Table_S2_Somatic_mutation_Genes_which_are_high_frequency_in_TP53_signature_MT_TCGA_data_4_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XGQ4-1326-SM-4GIDU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917188
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.22436
GTEX-R45C-0926-SM-3GAD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
3-nitropropionic acid-6402	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K08311368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23743
AD-00-WA10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.72476
CRCGN015_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83745
PMC8635809-Table_2.xls-LPS-downregulated-Unnamed_4_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A5SM-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF257	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	112.187
GTEX-QDVJ-0226-SM-2I5FV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14919
CRCGN017_MCF10A.TP53.M_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62042
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PD 160170	DeepCoverMOA Drug Mechanisms of Action	1.0	1.88
Perturb_7724_KO_MED12_SRP201365	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.6231
GSE202434,GSE202438_6_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A6RY-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K39516553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03356
GSE142210_3_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LP-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XPVG-2126-SM-4B667	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
HES5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.406
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A5RI-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SJXC-0126-SM-2XCFF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
SCC-9	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28321
VCAP	DepMap CRISPR Gene Dependency	1.0	2.6043
BRD-K73125384_Acetic acid N-(2-methoxy-phenyl)-N-[3-oxo-3H-benzo[b]thiophen-(2Z)-ylidene]-hydrazide_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
tauopathy	GWASdb SNP-Disease Associations	1.0	0.911472
BRD-K60870698_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HNF4A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K36111748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2265
GSE180147_0_v_1_itga5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
reticulotegmental nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.863734
Adrenocortical carcinoma_ACC_TCGA-OR-A5K0-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE238018_3_v_5_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XUJ4-0008-SM-4BOQI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
SP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07824
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
5155877-6549	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Colorectum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_6740_KD_VPS4A/VPS4B_SRP187973	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.44394
KU1919_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	10.3948
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.899826
GTEX-WFJO-0726-SM-4LVM8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Perturb_15571_OE_circCSPP1_SRP286288	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.4591
BRD-K96737756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.05754
BRD-K20755323_-666_MCF7_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
SKI II	DeepCoverMOA Drug Mechanisms of Action	1.0	1.07
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.69249
GR79236	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.43
CRCGN016_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.75055
BACH1-22875853-CHIP-PCR-HELA-AND-SCP4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
STAT3_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCC-FG2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.39887
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
growth abnormality	GWASdb SNP-Phenotype Associations	1.0	0.693745
CRCGN017_MCF10A.TP53.M_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3653
GTEX-VJWN-0126-SM-3GIK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213102
SP in perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10964
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K04409515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35301
BRD-K10923439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3132
GSE168797_1_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Biological oxidations	Reactome Pathways 2024	1.0	null
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3672
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
18704457-Table2	GeneSigDB Published Gene Signatures	1.0	null
cognitive disorder	GWASdb SNP-Disease Associations	1.0	0.128634
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-PVOW-1626-SM-48TC9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20287
GTEX-O5YW-0126-SM-3LK6D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
SPI1	ENCODE Transcription Factor Targets	1.0	null
MFE280	DepMap CRISPR Gene Dependency	1.0	2.01778
levocabastine-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19989
GTEX-OHPN-0011-R5A-SM-2I5FF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857697
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K99097591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46368
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.74391
atropine oxide-2216	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE175787_4_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RP-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K47854067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22797
BRD-K98548675_Parthenolide_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K74873856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17638
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
CRCGN015_HEPG2_48H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18427
etacrynic acid-3181	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K36me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hydralazine-3621	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PL-21	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.584
liver	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-R55G-1026-SM-48FDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40031
GSE239844_8_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K21180458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26903
8305C_THYROID	CCLE Cell Line Proteomics	1.0	3.45668
BRD-K18438502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3065
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
paracentral lobule, posterior part, left, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.83929
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A115-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10970410__F8	PFOCR Pathway Figure Associations 2024	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8S9-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
D502MG	DepMap CRISPR Gene Dependency	1.0	2.23837
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Tafluprost	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.43
BRD-K29975122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27662
GSE158632_3_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
TK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03087
Perturb_3779_KD_NFYA_SRP041162	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-14.9441
GTEX-TMZS-0326-SM-3DB9P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
endoplasmic reticulum membrane	GO Cellular Component Annotations 2023	1.0	null
MZ in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27408
pentolonium-4699	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
NFIC_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.433757
GTEX-QEG4-0226-SM-2S1PY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
SG in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.844128
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2ML-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X4EP-0726-SM-3P5YJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04914
Brain Lower Grade Glioma_LGG_TCGA-VM-A8C9-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A64237946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7044
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TSE9-2626-SM-4DXV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)	Reactome Pathways 2014	1.0	null
CDK8_knockdown_161_GSE38061	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.43694
basolateral nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.4622
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03087
GTEX-S7SE-0008-SM-33HB1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-UJHI-0426-SM-3DB8Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29784
GTEX-XXEK-0008-SM-4BRW7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)	Reactome Pathways 2014	1.0	null
brompheniramine-4131	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
catabolic process	GO Biological Process Annotations 2015	1.0	null
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.889557
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
PMC7181746-41467_2020_15886_MOESM8_ESM.xlsx-Patient_8_CCF-Affected_Genes_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A75421526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87384
CAPAN-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NFIC	ENCODE Transcription Factor Targets	1.0	null
GTEX-SNMC-0526-SM-4DM69	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06789
Arachidonic acid metabolism	Reactome Pathways 2014	1.0	null
Defective CYP1B1 causes Glaucoma	Reactome Pathways 2014	1.0	null
BRD-K39534157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37139
MKN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03087
BRD-K98639224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52509
CRCGN017_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34447
GSE182179_0_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
meropenem-3564	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular part	GO Cellular Component Annotations 2015	1.0	null
smallintestine_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.03076
mianserin-2231	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
endomembrane system	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-8537-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K59550348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1863
RAD21	ENCODE Transcription Factor Targets	1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19413
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
16044152-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
Breast Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K53706972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55936
Brain Lower Grade Glioma_LGG_TCGA-HT-A5R5-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ4-1626-SM-3P618	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19634
A549_ITSA-1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150718
endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CRCGN008_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6012
GSE142210_3_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.434906
CRCGN015_MCF10A.TP53.M_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5968
BMS309403	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
PHA-00851261E-3965	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
activities	GeneRIF Biological Term Annotations	1.0	null
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11983
GTEX-SNOS-1226-SM-4DM5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
AdrenalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.847867
GSE193541_0_v_3_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5059470-ncomms12992-s6.xlsx-CRS-NOCRS-Supplementary_Data_5_Integration_Frequency_in_cirrhotic_CRS_and_non-cirrhotic_no-CRS_Tumor_Samples_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148262,GSE150691_1_v_0_hdlbp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NIHOVCAR3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38365
nitrofurantoin-4697	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
defense response	GO Biological Process Annotations 2015	1.0	null
GTEX-Q734-0326-SM-48U15	GTEx Tissue Sample Gene Expression Profiles	1.0	2.11837
Uterus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.02858
POLR2A	ENCODE Transcription Factor Targets	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.5722
GTEX-T2IS-2026-SM-4DM6W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
CRCGN015_MCF10A.WT.HP_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18873
dorsolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.015
Succinobucol	DeepCoverMOA Drug Mechanisms of Action	1.0	0.34
Fatty acid metabolism	Reactome Pathways 2024	1.0	null
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.30596
VPRBP_KD_GDS4829_90_human_DU145 prostate cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-XQ8I-1526-SM-4BOOH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19674
GSE229973_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A20F-06A-21R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K21332842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01004
layer II of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.36975
BRD-K96958073	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28777
GSE168401_1_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S3XE-0926-SM-4AD4S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847068
solasodine-3924	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AC-84-QG99_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.349303
cefoperazone-5424	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K40306365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00127
Down Syndrome_Brain_GSE5390	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.0665
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Prostate adenocarcinoma_PRAD_TCGA-VP-A872-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.890605
BRD-K28853245	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32403
PORCN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02534
UT7	CCLE Cell Line Gene CNV Profiles	1.0	1.73216
Omegae	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.651
keratinocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.485545
Perturb_3698_KD_FTO_SRP226373	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-16.2672
Lung adenocarcinoma_LUAD_TCGA-05-4389-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6830-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
DA-35-DU85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.422115
A549_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151187
CRCGN017_MCF10A.WT.HP_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.77435
GTEX-OIZH-0326-SM-2HMKC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.24816
midbrain raphe nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.56732
BRD-K29898553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04196
GTEX-U3ZN-1726-SM-4DXUQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27805
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.356567
GTEX-QLQW-1226-SM-2S1Q9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Bladder Urothelial Carcinoma_BLCA_TCGA-E5-A2PC-01A-11R-A206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2998	BioGPS Cell Line Gene Expression Profiles	1.0	1.43209
Perturb_12197_KD_ERCC6_SRP310546	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RTLS-1126-SM-46MUQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14647
callosal sling	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.832692
GTEX-P78B-0826-SM-3NMCA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.905881
GSE142210_11_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SJSA-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
folic acid_homo sapiens_gpl2700_gds3656	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7261-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K11577431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21025
vitamin k metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
vitamin K catabolic process	GO Biological Process Annotations 2025	1.0	null
AB-30-CR11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288449
bretylium tosilate-3394	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
lung_4a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)	Reactome Pathways 2014	1.0	null
GTEX-PX3G-0826-SM-48TZS	GTEx Tissue Sample Gene Expression Profiles	1.0	2.1921
arachidonate metabolic process	GO Biological Process Annotations 2025	1.0	null
retroparafascicular area of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.82102
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11863
KMRC20	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43471
CRCGN015_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.21776
F36P	CCLE Cell Line Gene CNV Profiles	-1.0	-1.85075
CRCGN008_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4362
Ichthyosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.77424
SNU668	CCLE Cell Line Gene CNV Profiles	1.0	1.73822
NCI-H727	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.70243
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
EP300	ENCODE Transcription Factor Targets	1.0	null
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.40758
GTEX-R3RS-1326-SM-48FE7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891452
H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SQ-A6I4-11A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
sulfapyridine-2538	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4506-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WYJK-0526-SM-3NM8Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-X5EB-1926-SM-4E3IW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-PLZ4-1226-SM-2I5FE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850391
lesser	GeneRIF Biological Term Annotations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7290-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MI-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MZ in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14987
AE-05-CB45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.369482
liver cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.122104
small molecule catabolic process	GO Biological Process Annotations 2015	1.0	null
496100327_PCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.18011
cellular_component	GO Cellular Component Annotations 2015	1.0	null
BRD-K87920761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67637
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.314271
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4713-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1666	DepMap CRISPR Gene Dependency	1.0	2.43047
GTEX-T6MN-1226-SM-3NMA5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90446
GTEX-U4B1-0008-SM-4DXUW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
maprotiline-3236	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K61560971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90315
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-d-Classification_of_camel_SON_basal_genes_-_enzymes_SON	Rummagene Transcription Factor Associations 2026	1.0	null
lateral hypothalamic area, tuberal region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.86761
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QV44-0926-SM-2S1RH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Prestwick-984-7323	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PWN1-0626-SM-48TDT	GTEx Tissue Sample Gene Expression Profiles	1.0	2.01179
GTEX-XXEK-1026-SM-4BRUW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74079
Metabolism	Reactome Pathways 2024	1.0	null
CRCGN010_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62949
GTEX-XXEK-2526-SM-4BRUR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854567
PMC10335677-pbio.3002161.s009.xls-MLL_siRNA_DEGs-Ensembl_ID_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB1-F2del_7Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.96604
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.12889
BRD-K62547690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11644
GSE119978,GSE180930_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Obesity	HuGE Navigator Gene-Phenotype Associations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-8158-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.8874
NOZ	DepMap CRISPR Gene Dependency	1.0	2.82573
BRD-K05950670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99726
basomedial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.28348
GTEX-OHPM-0008-SM-4E3IP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
CRCGN015_HEPG2_48H:M24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14132
GSE48812_2_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-NPJ7-0008-SM-4E3JS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BRD-K26748243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24934
H3K4me1_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE192870_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S95S-1326-SM-2XCDK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.042415
BRD-K48332223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23913
BEN	CCLE Cell Line Gene Expression Profiles	1.0	1.46968
sulfaguanidine-4257	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NKM-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Defective CYP19A1 causes Aromatase excess syndrome (AEXS)	Reactome Pathways 2014	1.0	null
vitamin K metabolic process	GO Biological Process Annotations 2023	1.0	null
BATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3187
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6023-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
menaquinone metabolic process	GO Biological Process Annotations 2025	1.0	null
15-delta prostaglandin J2-5591	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-SUCS-0008-SM-4DM53	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
tinidazole-2568	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PTEN_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.576
Kidney renal papillary cell carcinoma_KIRP_TCGA-4A-A93X-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_EED226_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021954
Metabolism of lipids and lipoproteins	Reactome Pathways 2014	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7854-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
emboliform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.839704
iron ion binding	GO Molecular Function Annotations 2015	1.0	null
tolfenamic acid-5454	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7422-01A-21R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
haloperidol-2704	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74626
rosiglitazone-6950	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17331
vitamin K metabolic process	GO Biological Process Annotations 2025	1.0	null
lateral habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.56129
cytochrome metabolic process	GO Biological Process Annotations 2025	1.0	null
spleen_3d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
PMC9061835-41523_2022_425_MOESM1_ESM.xlsx-S3_Differential_GEX-Table-S3_Differential_expression_analysis_results_for_SOX10-high_versus_SOX10-low_TNBCs_from_the_TGCA_and_METABRIC_expression_datasets_SOX10	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7554653-mmc6.xlsx-ST5A-a_Top_10_genes_from_gene_burden_analysis_for_damaging_LoF_and_D-mis_variants_with_MAF_1_10-4_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
lateral hypothalamic area, anterior region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.99695
BRD-K38713368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12019
pentoxyverine-4649	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0179
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.612152
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-eTable_38_Cis-instrument_Mendelian_randomizaion_screen_of_1_901_cortical_proteins_on_lifetime_smoking_behavior_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
butyl hydroxybenzoate-5608	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)	Reactome Pathways 2014	1.0	null
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Thygro-r__CIC-2n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-3160-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
BRD-A67788537_Salermide_HT29_24.0_h_120.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
meclofenoxate-4729	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XUJ4-1326-SM-4BOQ9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
endoplasmic reticulum	LOCATE Curated Protein Localization Annotations	1.0	null
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.890605
Brain Lower Grade Glioma_LGG_TCGA-DU-5854-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE205332_2_v_0_queuine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K11596967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55076
BRD-K01888220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47908
BRD-K26161397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51631
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
H3K4me1_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.1601
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0169
GSE142210_11_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CAR-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN011_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4607
GSE236504,GSE236505_0_v_1_atmin_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
chlorpropamide-5391	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POU2F2	ENCODE Transcription Factor Targets	1.0	null
GTEX-X585-0008-SM-46MU4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
A549_PCI-34051_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168716
GTEX-U4B1-1726-SM-3DB9F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
CRCGN017_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.51975
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7SF-2226-SM-3K2BG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917347
Prostate adenocarcinoma_PRAD_TCGA-CH-5743-01A-21R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-XQ3S-1126-SM-4BOPK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09252
GTEX-RN64-0008-SM-48FEZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Sarcoma_SARC_TCGA-DX-A2IZ-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LC1F	CCLE Cell Line Gene Expression Profiles	1.0	1.85963
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57742
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12478272-mmc1.xlsx-Table_S7-Supplementary_Table_7_Proteome-wide_MR_and_sensitivity_analysis_results_using_the_brain_pQTL_dataset_from_Wingo_et_al_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_528_KO_NFE2L1_SRP333364	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.45525
GSE146982_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.57
GSE244518,GSE244520_1_v_0_dnmt3b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A77216878_manumycin A_CL34_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100622_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00064
probucol-5626	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K47415214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.711
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
tetroquinone-2999	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HNF4A	ChEA Transcription Factor Targets	1.0	null
BRD-K03352392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01295
BRD-A12830281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83232
H3K27me3_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11863
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43Y-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
PMC7260947-pnas.1912355117.sd02.xlsx-Sheet1-1185_common_genes_in_D_E_genes_KD_and_AcAPE1_ACOGG1_G4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
KYSE-520	GDSC Cell Line Gene Expression Profiles	1.0	1.68729
Metapathway biotransformation Phase I and II	WikiPathways Pathways 2024	1.0	null
CRCGN017_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0458
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A3LQ-01A-21R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7995-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:E01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.52411
alzheimer's disease	GWASdb SNP-Disease Associations	1.0	0.911472
GSE128730_0_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
bromocriptine-1507	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-8258-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K56889360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11267
GSE109140_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03446
GTEX-QDVJ-1926-SM-2S1PJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852003
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE241031_0_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H413	DepMap CRISPR Gene Dependency	1.0	2.30497
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	77.372
A549_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163064
GSE64513_0_v_1_foxd3_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.890605
omega-hydroxylase P450 pathway	GO Biological Process Annotations 2025	1.0	null
liver_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.27181
hsf1_17216044_hela_lof_human_gpl571_gds1733	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.250398
BRD-A39996500_radicicol_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-QDVJ-0005-SM-2TC5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Perturb_260_KD_PBRM1_SRP358304	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_7654_OE_CTCF_SRP128556	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.24267
Chromosome Aberrations	CTD Gene-Disease Associations	1.0	1.23456
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.458
SG in posterior frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03645
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81810589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41821
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VX-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
isometheptene-6524	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
withaferin A-3902	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K9me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K94476572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61786
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_12195_KD_ERCC4_SRP310546	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
CRCGN015_MCF10A_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16038
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN012_HEPG2_24H:J21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5275
SNU-398	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)	Reactome Pathways 2014	1.0	null
MHH-PREB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_HCT116_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-X6-A7WD-01A-21R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ibrutinib1	DeepCoverMOA Drug Mechanisms of Action	1.0	0.82
Ornithine carbamoyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.627
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.253692
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02779
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2155
CRCGN016_MCF10A.WT.HP_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9896
BRD-K83307202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.726
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K61924304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44561
GSE160304,GSE163392_0_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OXRN-2426-SM-2I5EQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846378
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.34822
NFIC_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_HEPG2_48H:B17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21135
BRD-K78315404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37495
icSARA deltaORF6_60Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.55844
BRD-K30491662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03608
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SK-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
endoplasmic reticulum membrane	GO Cellular Component Annotations 2025	1.0	null
NCI-H187	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K30937829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17091
Pons	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.18268
BCL11A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A87494167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98762
dapsone-5078	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SNU-484	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.826513
BRD-K18635665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59747
GTEX-WHWD-2426-SM-3LK6S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865357
TE11	CCLE Cell Line Gene Expression Profiles	1.0	1.8642
fat-soluble vitamin catabolic process	GO Biological Process Annotations 2023	1.0	null
LS-411N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
menaquinone metabolic process	GO Biological Process Annotations 2023	1.0	null
OB-65-AI50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.517234
CRCGN017_MCF10A.TP53.M_24H:E01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4982
outer CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02888
GTEX-QLQ7-0726-SM-2I5G2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56123
Endoplasmic reticulum membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
placenta_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6935-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7424-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN008_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76065
levobunolol-3015	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
19334046-TableS3a	GeneSigDB Published Gene Signatures	1.0	null
BATF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.966
AIF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00651096
central nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.49658
Arachidonic acid	HMDB Metabolites of Enzymes	1.0	null
valproic acid-6929	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3TU-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-P4QS-1126-SM-3NMD5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37405
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HL-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cytochrome P450 - arranged by substrate type	Reactome Pathways 2024	1.0	null
GSE140651,GSE140653_5_v_7_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9248879-supp_gr.275831.121_Supplemental_Table_S2.xlsx-TP53-dependent_proteins-GeneName_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K86453556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15936
GTEX-R55C-0626-SM-2TF4Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859981
GTEX-VJWN-0726-SM-3GIJ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
CHEMBL1597046	DeepCoverMOA Drug Mechanisms of Action	1.0	0.39
GTEX-XUJ4-2126-SM-4BOOX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
SW579	DepMap CRISPR Gene Dependency	1.0	2.22608
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BRD-K15924535	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05113
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
A549_JQ1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00988931
hsa-miR-4448	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
PMC4905481-oncotarget-07-11397-s003.xlsx-Pinin_KD-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T5JW-1226-SM-3GACY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28076
placenta_3a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
benzylpenicillin-6155	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
20035825-TableS8b	GeneSigDB Published Gene Signatures	1.0	null
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.828471
Celastrol	DeepCoverMOA Drug Mechanisms of Action	1.0	2.05
bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.050083
TAF1	ENCODE Transcription Factor Targets	1.0	null
A549_Tozasertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152671
aciclovir-1543	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NB4	DepMap CRISPR Gene Dependency	1.0	3.99929
PMC11625982-AJH-100-10-s001.pdf-9-ETS1_ETS1	Rummagene Transcription Factor Associations 2026	1.0	null
A-431	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.69249
GSE147626_2_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAF::NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.7578
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.35763
BRD-K27347421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15648
GTEX-OHPK-2526-SM-3MJH9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00272
15-delta prostaglandin J2-5228	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MOLM13	DepMap CRISPR Gene Dependency	1.0	3.7884
TFAP4::ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.2071
BRD-K06431655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29737
GTEX-RU72-2926-SM-2TF66	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907775
AE-13-CX28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289943
ELF1	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5359-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Icatibant	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.36
inferolateral temporal cortex (area TEv, area 20)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.957448
RMUGS	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49798
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K31721388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08354
BRD-K98251998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51306
GTEX-Q2AH-1126-SM-48TZM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18603
GSE234637_2_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-A75O-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
stratum radiatum of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.97604
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HE-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
monocarboxylic acid metabolic process	GO Biological Process Annotations 2025	1.0	null
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.157
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
HBE cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.839
IPC-298	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.58326
BRD-K69031148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02234
GSE80182_2_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cefepime-3581	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE146982_7_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.825952
FMK	DeepCoverMOA Drug Mechanisms of Action	1.0	1.21
18801183-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YAP_OE_GDS3220_32_human_MCF10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
rectum_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
G141	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.955409
rostral presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.869522
cellular ketone metabolic process	GO Biological Process Annotations 2015	1.0	null
FOXA2-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K58491882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23501
CEBPB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8505-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
placenta	HPA Tissue Gene Expression Profiles	-1.0	-1.29188
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nuclear outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.712
Adrenocortical carcinoma_ACC_TCGA-PA-A5YG-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
quinone catabolic process	GO Biological Process Annotations 2023	1.0	null
BRD-K83801418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18075
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
keratinocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.183192
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.13148
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A3IB-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane region	GO Cellular Component Annotations 2015	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8411-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
oleandomycin-1518	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Leukemialymphoblastic(MOLT-4)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.91876
capsaicin-3372	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NO-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-1913	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
clozapine-2644	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Disease	Reactome Pathways 2014	1.0	null
BRD-K67533212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09054
econazole-6008	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YJ-A8SW-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SE5C-0426-SM-4BRUI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24098
GSE153867_6_v_8_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GABPA_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
iohexol-4643	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K77634878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17338
GTEX-XUYS-0226-SM-47JX1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
HOXA5	JASPAR Predicted Transcription Factor Targets	1.0	null
superior olivary complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05191
Sebocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.81
KLM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.58621
Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)	Reactome Pathways 2014	1.0	null
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0247
Betamethasone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.56
ZBTB33_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R53T-0326-SM-48FEC	GTEx Tissue Sample Gene Expression Profiles	1.0	2.35706
BRD-K99532291_SPB02303_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2466
BRD-K00137579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22047
BRD-K36289461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30549
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
including	GeneRIF Biological Term Annotations	1.0	null
ACP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0054882
GSE149035_1_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
arterial stenosis	GWASdb SNP-Phenotype Associations	1.0	0.215286
CRCGN016_MCF10A.TP53.M_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.69924
HCC95	CCLE Cell Line Gene Expression Profiles	1.0	2.6732
CL11	CCLE Cell Line Gene Expression Profiles	-1.0	-1.72599
clenbuterol-5631	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
STAT5-23275557-MAMMARY-EPITHELIUM-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K34524418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04585
PMC12827430-41467_2025_67591_MOESM6_ESM.xlsx-Figure_4f-FOSL2_ChIP_WT-exclusive_genes_FOSL2	Rummagene Transcription Factor Associations 2026	1.0	null
ATF3-27146783-CHIP-SEQ-COLON-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0236
GSE169356_0_v_5_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.173057
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE142210_3_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.200556
BRD-A19615705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44442
BRD-K12909905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87625
GSE211474,GSE212779_0_v_1_phf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QDVN-1626-SM-48TZC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43472
GSE74251_2_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235587_2_v_1_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Azacitidine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179687
GTEX-V1D1-1926-SM-4JBGX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19389
BRD-K17790291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82417
CRCGN017_MCF10A.TP53.M_24H:E02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8061
A549_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141429
CRCGN015_MCF10A_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.3391
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen	GO Molecular Function Annotations 2015	1.0	null
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAFK	ENCODE Transcription Factor Targets	1.0	null
496100574_HIP_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.20895
GSE147876,GSE147877_4_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TMMY-1626-SM-4DXTY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919192
BRD-K83846772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1006
GSE193258,GSE193259_2_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CAKI2	CCLE Cell Line Gene Expression Profiles	1.0	2.19206
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCO2	CCLE Cell Line Gene CNV Profiles	1.0	1.59227
BRD-A39121618_7643233_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K30292003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35663
oxolamine-3344	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE57871_5_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.235964
transition metal ion binding	GO Molecular Function Annotations 2015	1.0	null
PMC5795782-supp_gad.302646.117_Supplemental_Table_S1.xlsx-Table_S1_2-Supplemental_Table_S1_2_Genes_significantly_upregulated_by_ARID5B_knockdown_ARID5B	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K48576794_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-62-A471-01A-12R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
diprophylline-5063	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Neoplasms	CTD Gene-Disease Associations	1.0	1.0869
GSE48812_8_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-4098-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CB-25-VR83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243832
ECC12	CCLE Cell Line Gene CNV Profiles	-1.0	-2.76325
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE171572_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RN64-1026-SM-48FDX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852911
membrane	GO Cellular Component Annotations 2015	1.0	null
renal	GAD High Level Gene-Disease Associations	1.0	0.293278
BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE199092_1_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	1.0	null
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45105
RD	DepMap CRISPR Gene Dependency	1.0	2.09723
CRCGN008_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.26835
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-U4B1-1626-SM-3DB8N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
NCIH1915	CCLE Cell Line Gene Expression Profiles	-1.0	-2.73481
SMZ1	DepMap CRISPR Gene Dependency	1.0	2.08366
securinine-6831	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN009_HEPG2_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04419
GSE245418_0_v_2_cd109_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K54862370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08893
PMC12827430-41467_2025_67591_MOESM6_ESM.xlsx-Supplementary_Figure_15l-FOSL2_ChIP_WT-exclusive_genes_FOSL2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S341-0626-SM-4AD5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859362
BRD-A39093044_K784-3187_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NFIX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.1236
hepatoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.740915
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QVUS-0008-SM-447AY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
SG in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00897
CRCGN016_MCF10A.TP53.M_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75664
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
ovary	GTEx Tissue Gene Expression Profiles	-1.0	-0.962591
GSE115763_3_v_1_klf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TT	CCLE Cell Line Gene Expression Profiles	1.0	1.71542
Lung squamous cell carcinoma_LUSC_TCGA-43-A475-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HGC27	CCLE Cell Line Gene CNV Profiles	1.0	1.47129
small intestine	HPA Tissue Protein Expression Profiles	1.0	1.23251
SLU7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10788
BRD-K03816923_Rottlerin_HT29_24.0_h_9.68_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
liver	HPA Tissue Gene Expression Profiles	1.0	1.28964
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC9643473-Table1.xls-MAF_0_005-Gene_refGenecanonical_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A19037878_trichostatin A_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
posterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.87008
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055869
SHSYSY+RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.46285
colon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE202434,GSE202438_8_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SMRT-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6951-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.12256
PMC10534007-Table_3.xlsx-S7_unique_up_MSC_V_2-312_elements_included_exclusively_in_VMCUB1_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A55408860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04882
Lipid storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.149
GTEX-UPK5-1426-SM-4JBHH	GTEx Tissue Sample Gene Expression Profiles	1.0	2.06396
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6010-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organic cyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
Fatty acids	Reactome Pathways 2014	1.0	null
BRD-K36737713_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cytochrome P450 - arranged by substrate type	Reactome Pathways 2014	1.0	null
Perturb_399_KO_NFE2L1_SRP333364	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.94793
A549_Andarine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178962
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AH-0826-SM-48TZN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82869
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE238018_1_v_0_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
paclitaxel_rattus norvegicus_gpl890_gse5337	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE236502_2_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
GTEX-QEG5-0826-SM-2I5GF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944531
U2OS	DepMap CRISPR Gene Dependency	1.0	3.49045
LN319	DepMap CRISPR Gene Dependency	1.0	2.33666
NCIH460	CCLE Cell Line Gene Expression Profiles	1.0	1.38445
aminohippuric acid-6453	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K48407262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46506
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S4UY-0926-SM-4AD6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36796
GTEX-PWN1-2626-SM-2I3FH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.908468
Defective FMO3 causes Trimethylaminuria (TMAU)	Reactome Pathways 2014	1.0	null
Perturb_6294_KO_KRT17_SRP314436	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
FOXA1	ENCODE Transcription Factor Targets	1.0	null
stratum radiatum of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.836606
GSE227592_4_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TML8-1526-SM-4DXUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46298
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2770-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K82064887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09405
BRD-K14258088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43326
PIK3AP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00623249
BRD-K21588993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10053
c-Fms-IN-3	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.27
BRD-K02118124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09218
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.035916
Arachidonate metabolism	Reactome Pathways 2024	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HG-A2PA-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A57E-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.45705
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.318745
fatty acid metabolic process	GO Biological Process Annotations 2023	1.0	null
ZBTB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.3134
BRD-K19411393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03807
A549_Carmofur_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00751305
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	1.0	6.78539
CRCGN015_HEPG2_48H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61835
hypoglossal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.885734
Nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
H3K36me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE135352_0_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN008_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9257
SUM52PE	DepMap CRISPR Gene Dependency	1.0	2.28779
CRCGN008_HEPG2_24H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1763
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Lung adenocarcinoma_LUAD_TCGA-78-7160-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
liver	GTEx Tissue Gene Expression Profiles	1.0	2.0623
GTEX-QEG5-1226-SM-447AR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939101
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-WFG8-1826-SM-4LVM4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.992888
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
FOSL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.987365
artery disease	GWASdb SNP-Disease Associations	1.0	0.099839
MFE-319	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN015_HEPG2_48H:B18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42375
DU4475	DepMap CRISPR Gene Dependency	1.0	2.83591
GTEX-T6MN-0926-SM-32PLX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BRD-K92317137_-666_SW948_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GM97	BioGPS Cell Line Gene Expression Profiles	1.0	0.915332
Acute Myeloid Leukemia_LAML_TCGA-AB-3012-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7064337-elife-51373-supp2.xlsx-847_genes_down-regulated-List_of_847_genes_down-regulated_after_PHF19_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
FOXA2-19822575-HEPG2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-N7MT-1426-SM-3LK5M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06919
amoxicillin-6285	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.20845
NB13	GDSC Cell Line Gene Expression Profiles	-1.0	-1.69249
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
SKN-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EH-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Eicosanoids	Reactome Pathways 2024	1.0	null
GSE146982_4_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37872081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48897
GSE142210_2_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
5182598-868	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
positively	GeneRIF Biological Term Annotations	1.0	null
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.870161
H3K27me3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XXEK-0326-SM-4BRVV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30435
GSE223893_11_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.62475
CRCGN016_MCF10A.WT.HP_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30214
H3K27me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
obesity	GWASdb SNP-Disease Associations	1.0	0.79774
STAT3	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RU72-0726-SM-46MUW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.972722
T3M10	CCLE Cell Line Gene Expression Profiles	1.0	1.40492
ZNF324	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1647
GTEX-QCQG-0008-SM-48U2G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
HCC2218	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.495959
GSE139455_0_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_11899_KD_SRC1_SRP108577	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE175787_5_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
DA-35-DU85_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244553
RMGI	CCLE Cell Line Gene Expression Profiles	1.0	1.3584
fungal-type cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.078
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.5388
GSE135514_8_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TP53BP1_KD_GSE54268_670_human_MCF-10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
norfloxacin-5985	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XMK1-0626-SM-4B65A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902128
BRD-K77320034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64924
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
renal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.358919
BRD-K18554416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8387
GTEX-XPVG-0008-SM-4GICH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9564215-pnas.2203480119.sd02.xlsx-OVCAR-5_SCD_KD_cultured_in_low-hgnc_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
small intestine	HPA Tissue Gene Expression Profiles	1.0	0.912027
H3K4me1_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SW780	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40635
H3K4me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-5847-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE175787_4_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	77.171
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RM-01A-21R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-97-A4M3-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K16551475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17255
496100281_HIP_probable Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.24073
connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.047405
GTEX-RU72-1426-SM-46MUF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80272
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	GO Molecular Function Annotations 2025	1.0	null
CRCGN010_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01274
thioridazine-5916	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192857
Brain Lower Grade Glioma_LGG_TCGA-P5-A5EY-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE146612_2_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.650966
Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)	Reactome Pathways 2014	1.0	null
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
GTEX-R55D-0008-SM-48FEV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q8-01A-31R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EP300_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sebum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.949
inflammatory response	GO Biological Process Annotations 2015	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7589-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE192362_1_v_0_erastin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-8601-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBED2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2722
BRD-A73741725_EXEMESTANE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QXCU-0008-SM-48FCH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
UMI-77	DeepCoverMOA Drug Mechanisms of Action	1.0	0.52
hsa-miR-18b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GTEX-XQ3S-2526-SM-4BOOG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854394
CRCGN017_MCF10A.TP53.M_24H:K18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29628
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.900614
Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)	Reactome Pathways 2014	1.0	null
midbrain reticular formation, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06664
BRD-K78866630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21526
GSE207135_1_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45021
PRPF19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28571
Liver Diseases	HuGE Navigator Gene-Phenotype Associations	1.0	null
DorsalRootGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.01077
BRD-K69175109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03436
butoconazole-5388	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Biological oxidations	Reactome Pathways 2014	1.0	null
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.375
P005091	DeepCoverMOA Drug Mechanisms of Action	1.0	0.59
orbital frontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.866108
GSE158969_1_v_2_trastuzumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
oxidoreductase activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-OHPL-0126-SM-2HMJ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
CEBPB	ENCODE Transcription Factor Targets	1.0	null
GSE165307_3_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.634
CRCGN015_HEPG2_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.995
methoxamine-4972	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BT20	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.00437
cofactor metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K94766933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1307
Oxygen	HMDB Metabolites of Enzymes	1.0	null
BRD-K38791044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0249
paracetamol-3364	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
liver cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.105704
BRD-K08417745_SID 26681509_HT29_24.0_h_88.8_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SW1573	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53274
CRCGN012_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.53125
NCIH2023	CCLE Cell Line Gene Expression Profiles	1.0	1.46003
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.58292
BRD-K94992087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60329
GSE146982_4_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GTEX-XBED-2626-SM-4E3J5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE197555_0_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3668
layer VI of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.943429
SIX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K00789767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56294
kawain-4693	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cingulate gyrus, frontal part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.23889
H3K4me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
medial subdivision of area 10	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.16214
ZBTB33	ENCODE Transcription Factor Targets	1.0	null
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.1996
MZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22783
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.02518
MAFF	ENCODE Transcription Factor Targets	1.0	null
BRD-K77697841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24443
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.602348
BRD-K37253893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28149
NR2F2	ENCODE Transcription Factor Targets	1.0	null
E2F1-20622854-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138254
Prinomastat	DeepCoverMOA Drug Mechanisms of Action	1.0	0.4
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Diazinon	CTD Gene-Chemical Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7051-01A-12R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-8009-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.19311
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4333
GSE138841_0_v_1_trim6_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K18346873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28553
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE130437_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cytochrome P450, conserved site	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K73494324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10399
Detroit562	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.46806
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7156-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
heterocyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.704349
GATA3_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.64953
A549_Carmofur_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185841
neostigmine bromide-6735	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.54898
BRD-K04949373_Parthenolide_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
NR3C1_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Q7-1026-SM-4AD75	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15059
Capsazepine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.44
thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.235616
Sulforaphane	DeepCoverMOA Drug Mechanisms of Action	1.0	1.92
GSE214931_4_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	86.2527
hsa-miR-1976	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
HER2_OE_GDS4763_331_human_MCF10A - immortalized breast epithelial cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.20375
GSE48812_0_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Large cell lung cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.019
Brain Lower Grade Glioma_LGG_TCGA-HT-7680-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K82968105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92456
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K20053005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6484
CRCGN016_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.43959
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21617
GSE114284_1_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146982_7_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.353
GSE114284_4_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K02473319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8275
AML193	DepMap CRISPR Gene Dependency	1.0	2.11187
JHOS4	CCLE Cell Line Gene CNV Profiles	1.0	1.85461
GTEX-OHPK-1526-SM-3MJGM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13173
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
H3K4me1_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE168797_4_v_6_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U3ZM-0526-SM-4DXTB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.914271
NFIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.0367
TE-6	GDSC Cell Line Gene Expression Profiles	1.0	1.5732
GTEX-QMR6-0008-SM-447AV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
496100579_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.09218
EGR1	ChEA Transcription Factor Targets	1.0	null
Metabolism of lipids	Reactome Pathways 2024	1.0	null
atractyloside-4717	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_14364_KD_SCD_SRP352005	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.45029
SG in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37729
H3K27ac_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-RN64-1826-SM-48FDV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79053
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5922
Acute Myeloid Leukemia_LAML_TCGA-AB-3001-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1937	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.768289
hsa-miR-4735-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE152734,GSE152735_2_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
17115125-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
BRD-K33454318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73065
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.344818
GTEX-T6MN-0008-SM-4DM7H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-XV7Q-0126-SM-4BRVK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
P63-20808887-KERATINOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE191015_1_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE184087_4_v_5_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146982_0_v_2_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K87034416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73546
Lung squamous cell carcinoma_LUSC_TCGA-18-3412-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAFG::NFE2L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.3004
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9853
BRD-K21409337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04562
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039931
GTEX-S3XE-0008-SM-3NM8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-R53T-1626-SM-3GAEW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
5162773-892	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
metitepine-5413	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GD-82-CS38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228962
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K55487965_NCGC00182364-01_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27me3_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.429628
G292CLONEA141B1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.77404
GTEX-PSDG-0726-SM-2I5FN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873547
GTEX-PSDG-1326-SM-48TD2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43015
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.27959
BRD-A16119053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76803
PMC10335677-pbio.3002161.s009.xls-MLL_siRNA_DEGs-Ensembl_Symbol_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
hsa-miR-3664-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Alectinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.74
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7254-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OAW-42	COSMIC Cell Line Gene Mutation Profiles	1.0	null
extent	GeneRIF Biological Term Annotations	1.0	null
CRCGN008_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6022
leflunomide-2539	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC11694450-Table_1.xlsx-MR_to_MM_at_2_DPI-Supplementary_Table_1_1_Differentially_expressed_genes_in_the_cecal_tonsil_transcriptome_in_the_M_R_group_compared_to_the_M_M_group_at_2_DPI_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A19500257_geldanamycin_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nes	HPA Cell Line Gene Expression Profiles	-1.0	-0.969415
4-Nitropiazthiole	DeepCoverMOA Drug Mechanisms of Action	1.0	1.57
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5304
GTEX-OXRL-2626-SM-2I3F1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951373
NCI-H1793	GDSC Cell Line Gene Expression Profiles	1.0	1.85861
Skin Cutaneous Melanoma_SKCM_TCGA-GF-A6C9-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.8472
BRD-K41999717	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06431
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GR-06A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
felbinac-3398	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.035814
GSE206729_4_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EL-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
phylloquinone metabolic process	GO Biological Process Annotations 2025	1.0	null
A549_Fasudil_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155224
FOSL2	ENCODE Transcription Factor Targets	1.0	null
GTEX-OOBJ-0226-SM-2YUMM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BRD-A78042852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05907
GTEX-QDT8-0226-SM-32PL4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
PMC2263127-pone.0001816.s001.xls-E2F3_down_Bild-Symbol_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
A549_AZD1480_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187164
GTEX-XGQ4-1526-SM-4AT6H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866369
GTEX-R45C-0008-SM-48FF2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
GTEX-OIZI-1426-SM-3NB1T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05214
SNU119	CCLE Cell Line Gene Expression Profiles	1.0	2.14084
BRD-K73340860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94534
vitamin catabolic process	GO Biological Process Annotations 2015	1.0	null
GSE197555_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
bacampicillin-4417	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6N0-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.02904
BRD-K74694052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10482
GTEX-S4P3-0426-SM-4AD56	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850084
BRD-K42489623_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE238116_3_v_0_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A0YX-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PKNOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.5938
A549_Resveratrol_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0121371
colistin-4212	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TTC442	DepMap CRISPR Gene Dependency	1.0	2.058
NRF2-31884422-A549-HUMAN-LUNG-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-N7MS-2326-SM-2HMLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE146982_7_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QEG5-1426-SM-447AS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955646
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5401
CREB1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE169334,GSE169336_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.19417
hsa-miR-4728-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
stratum lacunosum-moleculare of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.57236
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
GTEX-XMK1-2526-SM-4B666	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935639
GTEX-PLZ6-0526-SM-3P61C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82899
ZD-85-ND87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216091
HEC50B_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	2.86912
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BRD-K85912419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07228
PMC5741248__F10	PFOCR Pathway Figure Associations 2023	1.0	null
20-Hydroxyeicosatetraenoic acid	HMDB Metabolites of Enzymes	1.0	null
PIK3CA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00542987
BRD-K63997411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23154
GTEX-UTHO-1026-SM-3GAF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
RERFLCMS	CCLE Cell Line Gene Expression Profiles	1.0	1.55493
Perturb_366_KD_ARID1A_SRP198293	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.83306
BRD-K81804676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39818
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.428401
BRD-A68842442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87672
dextromethorphan-5401	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QESD-1526-SM-2S1QT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.4858
menaquinone metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
superior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.986327
GTEX-WFG7-1826-SM-3GIL1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.893898
SP in entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.884532
HCC1954	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.38257
BRD-K09473191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31057
GSE134615_1_v_0_lats1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HT1080	DepMap CRISPR Gene Dependency	1.0	2.27316
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
NFYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6045
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SG in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37347
STK746869	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
GTEX-S32W-0426-SM-4AD6H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918608
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.238
GSE239844_7_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36972
phylloquinone metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K77465015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78277
GTEX-QV44-0526-SM-2S1RE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-OXRN-0126-SM-48TDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.43289
Gastrointestinal Hemorrhage	HuGE Navigator Gene-Phenotype Associations	1.0	null
Lung Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
H3K4me1_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.3662
FGGY	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00511996
SSR 69071	DeepCoverMOA Drug Mechanisms of Action	1.0	0.91
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6867
GTEX-WFON-0826-SM-4LVMI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941143
A549_SRT2104_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156658
hepg2	HPA Cell Line Gene Expression Profiles	1.0	1.15097
5182598-976	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4514-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
polymorphic layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04162
GTEX-UTHO-2426-SM-4JBHD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47516
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.061771
LCLC-97TM1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.826513
Phase 1 - Functionalization of compounds	Reactome Pathways 2014	1.0	null
BRD-K91094364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43582
upper (rostral) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.868125
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.70243
Lung squamous cell carcinoma_LUSC_TCGA-LA-A446-01A-21R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
U138	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.830487
KMS27	CCLE Cell Line Gene CNV Profiles	-1.0	-1.98881
GTEX-XUYS-0008-SM-47JYZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
SG in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.56177
CRCGN017_MCF10A.TP53.M_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.43135
SW837	CCLE Cell Line Gene CNV Profiles	-1.0	-1.66806
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
keratinocytes	GeneRIF Biological Term Annotations	1.0	null
BRD-K84836394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16676
shsy5y	HPA Cell Line Gene Expression Profiles	-1.0	-0.969415
A549_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148042
PMC11694450-Table_1.xlsx-MR_to_MM_at_2_DPI-Unnamed_10_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
PSMC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10003
BRD-K82216975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21911
BRD-K38084509	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10778
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7924-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46H-01A-31R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S3XE-1226-SM-4AD4L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13804
HCC15	CCLE Cell Line Gene Expression Profiles	1.0	1.4954
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
NUGC3_STOMACH	CCLE Cell Line Proteomics	1.0	2.54366
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.2941
CDK19_knockdown_164_GSE38061	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.51635
nrf1_22586274_liver_lof_mouse_gpl4134_gse35124	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.198175
BRD-K37722313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09021
primary visual cortex (striate cortex, area V1/17)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.975917
Prestwick-692-4424	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
endoplasmic reticulum part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
USF1	ENCODE Transcription Factor Targets	1.0	null
BRD-K89933563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65388
GSE199092_2_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	1.0	null
JB-14-ZM03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301862
CRCGN017_MCF10A.TP53.M_24H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08
PC-14	GDSC Cell Line Gene Expression Profiles	1.0	1.44712
GATA3_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN013_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7599
GTEX-X4XY-1626-SM-46MVN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69285
naloxone-5243	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RPE1SS119	DepMap CRISPR Gene Dependency	1.0	3.41537
HCC1806	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.19218
globus pallidus, external segment, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05924
abnormality of the systemic arterial tree	GWASdb SNP-Phenotype Associations	1.0	0.117245
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8813
CRCGN016_MCF10A.TP53.M_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8643
CRCGN017_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.91219
CRCGN013_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68095
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_6862_KO_CDK19_SRP299261	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-V955-1126-SM-4JBH3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37071
GTEX-QXCU-0006-SM-2TC5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE175787_13_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.891961
GTEX-S7SF-0926-SM-4AD4M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27676
PMC3470785-NIHMS377161-supplement-3.pdf-600-GATA4_GATA4	Rummagene Transcription Factor Associations 2026	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K32506050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23897
Acute Myeloid Leukemia_LAML_TCGA-AB-2982-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K04559718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73901
Perturb_324_KD_BCAP31_SRP320890	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.34716
scoulerine-2891	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.36533
15-delta prostaglandin J2-1656	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
smallintestine_4b	HPA Tissue Sample Gene Expression Profiles	1.0	0.868675
BRD-K52989901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10102
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
placenta_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
BRD-K78062244_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
levodopa-4571	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
external granular (germinal) layer of lower rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.51663
GTEX-T8EM-0426-SM-4DM7E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907473
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.60593
BRD-A85860691_chaetocin_HT29_24.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSTM1	MSigDB Cancer Gene Co-expression Modules	1.0	null
pyrithyldione-2740	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22743
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Rectum adenocarcinoma_READ_TCGA-G5-6233-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDVJ-0726-SM-48U1W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24298
Heme	HMDB Metabolites of Enzymes	1.0	null
valdecoxib-6403	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K78493876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27238
GTEX-OIZG-0008-SM-4E3J2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-XV7Q-1226-SM-4BRVT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
20081105-ST-1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-REY6-1326-SM-48FDO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05543
COV434	DepMap CRISPR Gene Dependency	1.0	2.12106
GSE221633_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	1.0	null
HUPT3	CCLE Cell Line Gene CNV Profiles	1.0	1.66071
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T0-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:N19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00477
vitamin K catabolic process	GO Biological Process Annotations 2023	1.0	null
BRD-K00048155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04358
PMC9424213-41467_2022_32537_MOESM6_ESM.xlsx-siHNRNPK_cyto-DEGs_for_hnRNPK_KD_cytoplasmic_RNA_of_HeLa_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
isoconazole-2218	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K67844266_MLN4924_VCAP_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2609
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K67430561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.45515
NBTGR	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.2
PMC9894241-pnas.2211429119.sd05.xlsx-G3_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
dicoumarol-3848	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-V1D1-1026-SM-4JBHE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32196
abnormality of the cardiovascular system	GWASdb SNP-Phenotype Associations	1.0	0.043092
496100343_TCx_possible Alzheimer's disease_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.2935
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02982
CRCGN017_MCF10A.WT.HP_24H:O08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.8748
H3K27me3_CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AS-3777-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU1077	CCLE Cell Line Gene CNV Profiles	-1.0	-2.3073
abnormality of nervous system morphology	GWASdb SNP-Phenotype Associations	1.0	0.083938
FOXA1-25329375-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SARS-CoV MA15_Day4-PFU-10^4_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.84366
rt4	HPA Cell Line Gene Expression Profiles	1.0	0.850872
BRD-K04819729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31634
vascular disease	GWASdb SNP-Disease Associations	1.0	0.071251
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74326
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.291
metaraminol-4692	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K07712233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03267
GSE233647_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5694
496100323_FWM_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02595
SG in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00965
CRCGN015_HEPG2_48H:E18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36039
GATA3-24758297-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
coenzyme metabolic process	GO Biological Process Annotations 2015	1.0	null
CRCGN012_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3545
GTEX-OIZH-1426-SM-3NB1O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
hsa-miR-2467-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
BRD-K25917968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21297
CRCGN012_HEPG2_24H:J20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.05146
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5978-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ebolavirus(ZEBOV)_6day_PBMCs_rNAPc2treated_21987740_GSE24943	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-0.063231
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6940-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K61829047_7b-cis_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_JQ1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157771
BRD-K49999779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87932
LS-180	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WYBS-1926-SM-3NM8N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.971381
GSE71100_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T8EM-0526-SM-4DM64	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27474
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4815-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K98541397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14991
Perturb_9801_Mut_MALT1_SRP033466	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.25831
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG7-0008-SM-4LMKB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Lung squamous cell carcinoma_LUSC_TCGA-43-A474-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
parabigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.57868
GSE146982_7_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.873606
GSE119978,GSE180930_6_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119603_1_v_0_oxaliplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
guanabenz-1544	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE157609,GSE158123_0_v_1_ifi16_human	RummaGEO Gene Perturbation Signatures	-1.0	null
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.96442
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
pralidoxime-5383	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OCIMY5	DepMap CRISPR Gene Dependency	1.0	3.2399
GTEX-Q2AI-1126-SM-48U19	GTEx Tissue Sample Gene Expression Profiles	1.0	0.928852
16818684-Table2c	GeneSigDB Published Gene Signatures	1.0	null
Buccal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.845
Lung squamous cell carcinoma_LUSC_TCGA-22-5477-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE160817_5_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
morphological abnormality of the central nervous system	GWASdb SNP-Phenotype Associations	1.0	0.801631
Brain Lower Grade Glioma_LGG_TCGA-HT-A74H-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Aminoglutethimide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189509
BRD-K24689407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22716
long-chain fatty acid metabolic process	GO Biological Process Annotations 2025	1.0	null
BRD-K33350866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92607
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AB-18-YN11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201046
GTEX-S95S-1626-SM-2XCDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
A549_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178697
IRF4_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QV31-0126-SM-447BP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
metoprolol-6106	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WWYW-0826-SM-3NB2X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.963514
organelle part	GO Cellular Component Annotations 2015	1.0	null
GTEX-P4PP-1526-SM-3P61M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93762
CRCGN012_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.79987
PMC8025515-12859_2021_4105_MOESM12_ESM.xlsx-PW1-gene_stable_id_PEG3	Rummagene Transcription Factor Associations 2026	1.0	null
NCI 460	BioGPS Cell Line Gene Expression Profiles	1.0	1.67882
PBX3	ENCODE Transcription Factor Targets	1.0	null
GTEX-R55G-0008-SM-48FEX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE119978,GSE180930_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
ADAM19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00590357
GSE57397,GSE57399_1_v_0_fbxw7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
single-multicellular organism process	GO Biological Process Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-A492-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BC-62-RZ55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.426127
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NFIC::TLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.75
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE111247_2_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EGR1-19032775-M12-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
NCI-H1793	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.97385
GSE178532_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K97749477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33866
lateral nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.907719
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7044-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
long-chain fatty acid metabolic process	GO Biological Process Annotations 2023	1.0	null
NCI H322M	BioGPS Cell Line Gene Expression Profiles	1.0	2.41625
J82	GDSC Cell Line Gene Expression Profiles	-1.0	-1.89265
Pancreatic adenocarcinoma_PAAD_TCGA-FB-A4P6-01A-12R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BRD-K06956443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58469
GSE186633_1_v_0_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128730_3_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Smc5-Smc6 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.224
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DM-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE189789_0_v_1_oridonin_human	RummaGEO Drug Perturbation Signatures	1.0	null
latamoxef-3028	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
docosahexaenoic acid ethyl ester-881	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
meticrane-5984	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE160817_2_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE118077_7_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236228_0_v_1_penfluridol_human	RummaGEO Drug Perturbation Signatures	1.0	null
fat-soluble vitamin catabolic process	GO Biological Process Annotations 2025	1.0	null
OVSAHO	CCLE Cell Line Gene CNV Profiles	1.0	1.81545
GSE148096_1_v_0_erlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC515	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.693
GSE166783_4_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K66179451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09652
Isotretinoin	DeepCoverMOA Drug Mechanisms of Action	1.0	0.94
CRCGN009_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92692
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE146982_3_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TK10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11983
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18686
BRD-A97270959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.60052
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
microsomal	GeneRIF Biological Term Annotations	1.0	null
BRD-K51072560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0659
GTEX-XUJ4-0326-SM-4BOP9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849242
Lapatinib	DeepCoverMOA Drug Mechanisms of Action	1.0	1.46
GTEX-XBEW-0126-SM-4AT66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17785
GSE146982_3_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QV44-0008-SM-447AX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:J05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10352
BRD-K88150784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02508
bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.002594
abnormality of the vasculature	GWASdb SNP-Phenotype Associations	1.0	0.083096
20713713-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
BRD-K96054771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53794
CRCGN016_MCF10A.WT.HP_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.74061
Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)	Reactome Pathways 2014	1.0	null
ZNF707	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.0519
estriol-3563	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.484
hsa-miR-1915	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
central part of CEl	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.55647
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K97839095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35231
GTEX-RU1J-0008-SM-46MV9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
CAMA1	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.568369
BRD-K23204256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82085
H3K9ac_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
LDN-192960	DeepCoverMOA Drug Mechanisms of Action	1.0	0.55
GRHL2-25758223-PLACENTA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.67533
PMC10117100-msphere.00056-23-s0008.xlsx-2B-Supplementary_Table_S2B_mRNAseq_analysis_genes_significantely_downregulated_upon_E2F4-5_knockdown_in_38HK_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A13I-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
arsenic trioxide_homo sapiens_gpl201_gse48441	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-642a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
vitamin e deficiency	GWASdb SNP-Phenotype Associations	1.0	1.01499
Perturb_8749_OE_TP53_SRP131095	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
sisomicin-4132	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
substantia nigra, pars reticulata, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.33785
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34815
GSE229671,GSE229673_2_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	1.0	null
LS123	DepMap CRISPR Gene Dependency	1.0	3.07741
CRCGN015_MCF10A_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7039
tetrapyrrole binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91236
CRCGN010_HEPG2_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58268
Nilotinib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.57
H3K9ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-TMMY-1126-SM-4DXSX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19101
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
HPN	MSigDB Cancer Gene Co-expression Modules	1.0	null
GSE175787_11_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K31783598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16238
BRD-A23340824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52157
SG in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06949
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29017
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
oculomotor nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.21244
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.914624
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5878-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TE6	CCLE Cell Line Gene Expression Profiles	1.0	1.86849
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K11506071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16079
GTEX-QVUS-0226-SM-3GIJY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE211357_2_v_0_atg7_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
icosanoid metabolic process	GO Biological Process Annotations 2025	1.0	null
vigabatrin-5415	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K10398797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.029
HC-76-SY22_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206874
Prostate adenocarcinoma_PRAD_TCGA-EJ-5507-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ibrutinib2	DeepCoverMOA Drug Mechanisms of Action	1.0	0.8
Lung squamous cell carcinoma_LUSC_TCGA-77-8156-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NEC8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-412	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GTEX-XBED-1026-SM-48TCB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931665
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27027
GTEX-POYW-1226-SM-2XCEP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE166783_8_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3883
BRD-K27909962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63157
primary somatosensory cortex (area S1, areas 3,1,2)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.869022
MOLT13	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52365
diphenylpyraline-4765	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-up-Gene_ID_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
WPE1NA22	DepMap CRISPR Gene Dependency	1.0	2.6794
BRD-K18101782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00166
Kidney Chromophobe_KICH_TCGA-KM-8443-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bromopyruvic acid	DeepCoverMOA Drug Mechanisms of Action	1.0	0.87
sclc21h	HPA Cell Line Gene Expression Profiles	-1.0	-0.969415
BRD-K13489056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17161
CRCGN008_HEPG2_24H:F18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32955
GSE143692_0_v_1_trim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K21595913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11669
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
CRCGN015_HEPG2_48H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28112
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.2083
CRCGN010_HEPG2_24H:O08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04186
GSE138938_1_v_4_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
protein metabolic process	GO Biological Process Annotations 2025	1.0	null
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
response to stress	GO Biological Process Annotations 2015	1.0	null
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KC-11A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BCL11A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Seminal vesicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.296
boldine-4122	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26515
20081105-ST-2	GeneSigDB Published Gene Signatures	1.0	null
GSE48812_8_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K31747470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15756
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.349
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
gallbladder	HPA Tissue Gene Expression Profiles	1.0	0.920405
PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-up-Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132788
KYSE-520	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.32101
GTEX-Q2AG-0226-SM-2S1P4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
H3K27me3_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA3-26560356-CHIP-SEQ-TH2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE202434,GSE202438_6_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LCAT	MSigDB Cancer Gene Co-expression Modules	1.0	null
Cytochrome P450	InterPro Predicted Protein Domain Annotations	1.0	null
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3659
SKNMC	DepMap CRISPR Gene Dependency	1.0	2.15948
baclofen-5414	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
small molecule metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K96615474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22812
GTEX-T6MO-1726-SM-33HB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
colorectum	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
heme binding	GO Molecular Function Annotations 2015	1.0	null
TP63-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
chemdependency	GAD High Level Gene-Disease Associations	1.0	0.293278
GTEX-WY7C-2526-SM-3NB2N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
H3K27me3_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5041
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8357
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-N7MT-0011-R5a-SM-2I3G6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883465
S0-EE-WJKI_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.951725
fenbendazole-4542	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
INCB 3284	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
GTEX-OXRO-0326-SM-33HBM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
acacetin-3849	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.891015
GSE197555_0_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE153867_6_v_3_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
estropipate-6808	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-TML8-0008-SM-4DXUI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
cyp4a11	GeneRIF Biological Term Annotations	1.0	null
coronary artery disease	GWASdb SNP-Phenotype Associations	1.0	0.50495
CRCGN015_MCF10A_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.52292
BRD-K40939137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08158
GSE149901_2_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JVM2	CCLE Cell Line Gene Expression Profiles	-1.0	-2.24677
FOXA2	ChEA Transcription Factor Targets	1.0	null
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.71815
Amniocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.791
GSE221327_1_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15102
Lung adenocarcinoma_LUAD_TCGA-55-8620-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
frontal pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03293
BRD-K16387460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37655
BRD-K37971917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21818
icSARS CoV_30Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.8353
BRD-K82539366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4068
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5178-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pamidronic acid	DeepCoverMOA Drug Mechanisms of Action	1.0	0.32
hsa-miR-136	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Perturb_3755_KD_RNF40_ERP110773	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-S341-0226-SM-2XCAX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0155
t47d	HPA Cell Line Gene Expression Profiles	-1.0	-0.969415
ECC10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE142210_2_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE168401_2_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
picrotoxinin-4260	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
18318837-TableS1	GeneSigDB Published Gene Signatures	1.0	null
TCF3	ENCODE Transcription Factor Targets	1.0	null
MDS - Myelodysplastic syndrome_Bone marrow stem cell_GSE4619	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.43549
GTEX-XUYS-0005-SM-47JZ2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
phthalylsulfathiazole-4653	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE186767_1_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K15047839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95536
BRD-K40001806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24789
GSE125014_6_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
QGP1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.72159
Large intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
AC-75-LR63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205863
abnormality of vitamin e metabolism	GWASdb SNP-Phenotype Associations	1.0	0.416187
SARS-CoV MA15_Day2-PFU-10^4_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.59568
Perturb_12033_KD_MIR241_ERP110145	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-S4Q7-0926-SM-4AD5D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29249
CL-40	COSMIC Cell Line Gene Mutation Profiles	1.0	null
blood coagulation	GO Biological Process Annotations 2015	1.0	null
BATF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RB1_KD_GSE50532_593_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
coagulation	GO Biological Process Annotations 2015	1.0	null
abnormality of the coronary arteries	GWASdb SNP-Phenotype Associations	1.0	0.273815
H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-1926-SM-4DM6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7015
BRD-A37105798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23462
Lung squamous cell carcinoma_LUSC_TCGA-63-A5M9-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WRHU-0226-SM-3MJFV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAF1_overexpression_220_GSE42964	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.59755
BRD-K91235484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07345
ETK-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.65735
GTEX-RU1J-0326-SM-46MUM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13949
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC3348545-NIHMS263168-supplement-3.pdf-381-RFX1_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.337
HNF4A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.5075
GSE207471_2_v_0_btla_human	RummaGEO Gene Perturbation Signatures	1.0	null
ETV5::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.0993
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
binding	GO Molecular Function Annotations 2015	1.0	null
fatty acid metabolic process	GO Biological Process Annotations 2025	1.0	null
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-RM2N-1926-SM-48FCU	GTEx Tissue Sample Gene Expression Profiles	1.0	2.00891
GSE226355,GSE226357_1_v_0_ybx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XV7Q-1826-SM-4BRUV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A42L-06A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
outer portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.62629
GTEX-OOBK-0625-SM-3LK5P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46541
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.482
TCF12_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0008-SM-4E3JI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K43969492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05026
Bergenin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
CP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.42987
Preputial gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.479
GTEX-U3ZN-1226-SM-4DXUD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44702
pretectal nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.854708
arachidonic acid metabolic process	GO Biological Process Annotations 2023	1.0	null
NCI-H2030	GDSC Cell Line Gene Expression Profiles	1.0	1.41705
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JN-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
D341Med	DepMap CRISPR Gene Dependency	1.0	2.90767
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04979
PMC10870497-13046_2024_2976_MOESM12_ESM.pdf-20-FOXD1_FOXD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K69521416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07078
GTEX-S7SE-0005-SM-2XCEA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Prostate adenocarcinoma_PRAD_TCGA-EJ-5506-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBXAS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00626291
BRD-K92655427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22028
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
cancer	GWASdb SNP-Disease Associations	1.0	1.16174
Lung adenocarcinoma_LUAD_TCGA-86-8674-01A-21R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76125116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2134
GSE233647_2_v_3_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5485-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
deep layers of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16436
CRCGN013_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32561
subgenual (subcallosal) division of MFC (area 25)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.31073
TGBC24TKB	GDSC Cell Line Gene Expression Profiles	1.0	1.9038
menaquinone catabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K67809808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13286
LUDLU1	CCLE Cell Line Gene Expression Profiles	1.0	1.57827
JD-62-HR05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.823126
SP1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.015
BLZ-945	DeepCoverMOA Drug Mechanisms of Action	1.0	0.37
BRD-K71775851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13722
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11702
nizatidine-5406	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.4065
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-3_E2F2-Gene_E2F2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:L15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.85275
naloxone-4645	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SKMEL5	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.873214
GA-04-JM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216276
hsa-miR-324-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
A549_BMS-911543_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147879
Hydrogen Ion	HMDB Metabolites of Enzymes	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73043
GTEX-P4QT-0626-SM-3NMCP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39172
Water	HMDB Metabolites of Enzymes	1.0	null
ICC9	DepMap CRISPR Gene Dependency	1.0	2.97264
molecular layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.44443
SARS-BatSRBD_60Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.96065
cingulate gyrus, retrosplenial part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.940283
GSE206516,GSE206518_1_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SM-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Crus II, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.45156
Perturb_14644_KO_PC_SRP388542	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.8162
BRD-K52414345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11384
GTEX-XBEC-0008-SM-4AT3X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-X638-0008-SM-47JZ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE214931_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5788-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_FLLL32_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165352
NCI-H2171	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-PWO3-0011-R6A-SM-2I5F3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866188
NCI-H838 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.793
BRD-K39813155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71852
GSE57871_6_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tretinoin-6931	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
dementia	GWASdb SNP-Disease Associations	1.0	0.403924
PMC10534007-Table_3.xlsx-S7_unique_up_MSC_V-312_elements_included_exclusively_in_VMCUB1_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WFON-1726-SM-4LVMQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.98302
GTEX-QESD-1426-SM-2S1R9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Lung squamous cell carcinoma_LUSC_TCGA-68-A59J-01A-21R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.307011
BRD-K64602559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10202
Testolactone	DeepCoverMOA Drug Mechanisms of Action	1.0	2.07
SP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.826306
digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.796041
GSE57871_5_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BRD-K61929684	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2948
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.25605
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34939
gallbladder_5b	HPA Tissue Sample Gene Expression Profiles	1.0	1.27245
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VK-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054464
GSE203485_1_v_0_sunitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-548an	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_1_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JF-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7,3,4-THIF	DeepCoverMOA Drug Mechanisms of Action	1.0	0.79
A549_Alvespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139961
A549_Fasudil_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154272
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCIH446	DepMap CRISPR Gene Dependency	1.0	3.08111
IPC298	CCLE Cell Line Gene CNV Profiles	1.0	1.56677
CEBPB-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
COLO-704	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01795
BRD-A47416464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50511
A549_PHA-680632_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131552
hsa-miR-1270	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
NFIC_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-UJHI-1026-SM-4IHJP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	1.0	0.857103
GTEX-PWCY-0726-SM-48TCS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24341
GTEX-QDVJ-1126-SM-48U1U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987004
alvespimycin-6973	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cytoplasmic part	LOCATE Curated Protein Localization Annotations	1.0	null
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057747
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-8200-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K74402642_Chemistry 2804_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XUJ4-2626-SM-4BOQ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-S32W-0926-SM-4AD5X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30197
GSE197555_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QLQ7-0926-SM-447BC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39156
GTEX-S4P3-0226-SM-3K2BD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.936023
WM278	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.97483
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE229973_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Zotarolimus	DeepCoverMOA Drug Mechanisms of Action	1.0	0.5
NP8	DepMap CRISPR Gene Dependency	1.0	3.96514
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39426
CRCGN015_MCF10A_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.2556
GSE82104,GSE82299_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
GTEX-PX3G-0008-SM-48U2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BRD-K54250149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0347
GSE206516,GSE206518_2_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SPIB	JASPAR Predicted Transcription Factor Targets	1.0	null
hsa-miR-3689c	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7716
GTEX-R53T-0008-SM-48FEW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
placenta_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
UACC-812	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K99982687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05843
SNU761	CCLE Cell Line Gene CNV Profiles	-1.0	-1.94173
BRD-K43915000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37528
bone resorption disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.208579
BRD-K16305571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82178
FU97	CCLE Cell Line Gene CNV Profiles	1.0	2.04926
BRD-K07152092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38622
BRD-K00590556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30191
RD-79-FH72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.333227
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-NFE2L2_V2-Gene_name_NFE2L2	Rummagene Transcription Factor Associations 2026	1.0	null
adenosine phosphate-3237	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
diabetes mellitus	GWASdb SNP-Disease Associations	1.0	1.16174
P68-20966046-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-XPVG-2626-SM-4B669	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
CRCGN010_HEPG2_24H:O09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73673
alprenolol-6789	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K57782577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54616
Ventral disc	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.723
NCI-H1355	GDSC Cell Line Gene Expression Profiles	1.0	1.70163
Lung adenocarcinoma_LUAD_TCGA-49-6742-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T5JW-1326-SM-4DM5G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37593
GSE206516,GSE206518_6_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
NFIC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06993
Eicosanoids	Reactome Pathways 2014	1.0	null
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-OOBJ-0326-SM-33HBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258127
Lung adenocarcinoma_LUAD_TCGA-69-8255-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UMC-11	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K86584551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37686
496100561_PCx_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02902
CRCGN017_MCF10A.TP53.M_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34877
medial parabrachial nucleus,right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.965047
CDAN1_02_197	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.58496
BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_NCIH508_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
A549_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163662
BRD-K97692908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34269
EP300_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
omega-hydroxylase P450 pathway	GO Biological Process Annotations 2023	1.0	null
HNF4A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K97569931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26903
CRCGN011_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60745
A172	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.970713
KURAMOCHI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K05331696_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.58093
CDK8_knockdown_63_GSE19199	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.56755
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5EB-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE136340_1_v_2_darunavir_human	RummaGEO Drug Perturbation Signatures	1.0	null
outer CP in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07713
inner CP in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.32791
KHM1B	CCLE Cell Line Gene CNV Profiles	1.0	1.36283
ZBTB33_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
oxyphenbutazone-6844	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
GSE168797_1_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A36275421_MW-ras12_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
inferior colliculus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02176
GSE238018_1_v_5_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
20548326-Table4	GeneSigDB Published Gene Signatures	1.0	null
GTEX-RNOR-0008-SM-48FEY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6012-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO 794	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.854359
IM95_STOMACH	CCLE Cell Line Proteomics	1.0	3.05603
A549_Clevudine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189485
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE123689_1_v_0_cbx8_human	RummaGEO Gene Perturbation Signatures	1.0	null
butyl hydroxybenzoate-4647	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S341-0526-SM-4AD5U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25851
precursors	GeneRIF Biological Term Annotations	1.0	null
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K63584084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24265
ZXDC_KD_GDS5070_504_human_U937	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
liver_d	HPA Tissue Sample Gene Expression Profiles	1.0	1.25936
BRD-A99344113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.30414
Z32036776	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.43
18387200-Genes	GeneSigDB Published Gene Signatures	1.0	null
GSE192860_0_v_1_trifluoperazine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A60386802_MLS-0315872.0001_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cingulate gyrus, retrosplenial part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.18113
metal ion binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K91060460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19735
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.607744
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.168
GTEX-X4XX-0626-SM-3NMC1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-M7-A721-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4281	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
SUM102PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.894033
FECH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00539215
PMC3029394-pone.0016617.s001.xls-Down-regulated-Table_S1_Genes_down-regulated_by_SOX2_over-expression_0_5-fold_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K61829047_7b-cis_CL34_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
flecainide-3937	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.968244
gallbladder	HPA Tissue Protein Expression Profiles	1.0	1.23251
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.19447
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EE-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SJXC-0008-SM-4DM7G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
icSARA deltaORF6_54Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.96262
FOXA2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49583
succinylcholine-chloride	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04868
BRD-K23405293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24709
PMC3230611-pone.0028509.s004.xls-Sheet1-Supplementary_Table_S2_The_list_of_273_differentially_expressed_genes_after_transfection_of_STAT6_specific_siRNA_in_NCI-H460_cells_STAT6	Rummagene Transcription Factor Associations 2026	1.0	null
TCF12	ENCODE Transcription Factor Targets	1.0	null
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PLCPRF5	DepMap CRISPR Gene Dependency	1.0	3.55436
SW579	CCLE Cell Line Gene CNV Profiles	1.0	1.85266
PMC7397849-supp_gad.338681.120_Supplemental_Table_S1.xlsx-S1L_Shared_genes_3way_overlap-Suppl_Table_S1L_Shared_genes_between_YAP1-MAMLD1_YAP1-FAM118B_YAP1-TFE3_in_vitro_human_samples_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
chloropyramine-4414	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-XBED-0926-SM-48TCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
HUT78	CCLE Cell Line Gene CNV Profiles	-1.0	-1.56935
regulation of body fluid levels	GO Biological Process Annotations 2015	1.0	null
GTEX-WFG7-1126-SM-4LMK3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14762
ONS76	DepMap CRISPR Gene Dependency	1.0	2.63609
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A5A4-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A549_MLN8054_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160689
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
PMC11297914-41389_2024_531_MOESM1_ESM.pdf-250-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
GSE207471_2_v_3_btla_human	RummaGEO Gene Perturbation Signatures	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
EZH2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PK-59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48625
SkeletalMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.25532
remoxipride-5443	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-X8HC-1626-SM-46MWE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
SK-LMS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BT483	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39816
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XP-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Organelle subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.900842
liver	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TT-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	1.10796
hsa-miR-26b-5p	MiRTarBase microRNA Targets	1.0	null
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_2_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202434,GSE202438_4_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OXRP-0526-SM-2I3EW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-SUCS-0726-SM-4DM7J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988254
Lung adenocarcinoma_LUAD_TCGA-78-7150-01A-21R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	Reactome Pathways 2014	1.0	null
carboplatin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30958
androsterone-5696	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.40064
HDAC2	ENCODE Transcription Factor Targets	1.0	null
OCI-M2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19024
CRCGN012_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2728
GSE77108_0_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH1944	CCLE Cell Line Gene CNV Profiles	-1.0	-1.78008
GSE121866_0_v_2_six4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RARA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.8263
FOXA1_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K10087503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07807
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
GSE146982_3_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27027
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K27372445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08298
BRD-K63354944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23937
ntera2	HPA Cell Line Gene Expression Profiles	-1.0	-0.969415
periaqueductal gray substance, dorsolateral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.946634
SNU1076	CCLE Cell Line Gene CNV Profiles	-1.0	-1.75341
GTEX-OOBJ-0826-SM-3NB2K	GTEx Tissue Sample Gene Expression Profiles	1.0	2.19419
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K51278788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33828
Perturb_258_KD_PBRM1_SRP358304	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
CRCGN009_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68149
TUBA1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92201
Uterine Carcinosarcoma_UCS_TCGA-NF-A5CP-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
biological regulation	GO Biological Process Annotations 2015	1.0	null
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.899826
CRCGN009_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.24633
BRD-K13085116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27275
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
A549_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01987
phylloquinone catabolic process	GO Biological Process Annotations 2015	1.0	null
pineal gland	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.12927
15-delta prostaglandin J2-6990	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_HEPG2_48H:B16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04154
BRD-K93516545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04781
EGR1-19032775-M12-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.169571
GTEX-POYW-0526-SM-2XCEY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
rilmenidine-6512	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
arteriosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.239958
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K55763052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41561
BRD-K02053819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10488
BRD-K15768601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01331
BRD-K41206520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04136
GSE148657_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XPVG-0826-SM-4B654	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
CRCGN013_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39879
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-QDVN-2026-SM-3GAEP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Quizartinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.64
Lung squamous cell carcinoma_LUSC_TCGA-18-3411-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.91263
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	1.0	2.18534
GTEX-WEY5-0926-SM-4LMI4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13268
GSE166914_1_v_0_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-97-8176-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PI-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
L1236	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54421
GSE205730,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
18318837-Table1	GeneSigDB Published Gene Signatures	1.0	null
A549_Streptozotocin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180825
OlfactoryBulb	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.879953
GTEX-X4XX-0008-SM-46MVK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GTEX-U8XE-1526-SM-4E3HT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92648
BRD-K73337367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04177
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.11571
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.9015
GSE149901_3_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MZ7-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER	ChEA Transcription Factor Targets 2022	1.0	null
H3K9ac_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T6MO-0426-SM-32QOI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
polymorphic layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13841
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RVPV-0526-SM-47JYL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14687
PMC4905481-oncotarget-07-11397-s002.xlsx-Pinin_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K28366633_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27me3_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE233049_1_v_3_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RXRA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ1-0326-SM-4DXSM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958008
dorsolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.30494
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
CRCGN015_HEPG2_48H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22325
GTEX-SIU8-0826-SM-2XCDQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
CRCGN016_MCF10A.WT.HP_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.37414
v433m	GeneRIF Biological Term Annotations	1.0	null
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.982059
IRF4_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE139455_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOXP1_01_209	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.89808
ONX 0914	DeepCoverMOA Drug Mechanisms of Action	1.0	2.62
cortico-medial group, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.879021
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BATF::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0768
quinone metabolic process	GO Biological Process Annotations 2015	1.0	null
gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_2484_Mut_ESR1_SRP254635	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.952664
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Lung squamous cell carcinoma_LUSC_TCGA-85-8354-01A-31R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney Failure, Chronic	HuGE Navigator Gene-Phenotype Associations	1.0	null
TCF3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Metabolic disorders of biological oxidation enzymes	Reactome Pathways 2014	1.0	null
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5988
hsa-miR-4329	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
H3K27me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FEZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.2038
LIM1215	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6933-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S32W-2526-SM-2XCB8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99624
menaquinone catabolic process	GO Biological Process Annotations 2025	1.0	null
FOXA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JHU-022	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-S4Q7-0226-SM-4AD5O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84679
GTEX-S4Z8-0526-SM-4AD4T	GTEx Tissue Sample Gene Expression Profiles	1.0	2.27471
COLO678	DepMap CRISPR Gene Dependency	1.0	2.26624
MCC26	DepMap CRISPR Gene Dependency	1.0	2.76171
azacyclonol-5398	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
F36P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	6.85765
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U4B1-0926-SM-4DXUV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
OV90	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41488
GTEX-UJMC-0926-SM-4IHLK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27563
Brain Lower Grade Glioma_LGG_TCGA-CS-6188-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
omegahydroxylated	GeneRIF Biological Term Annotations	1.0	null
TEK_knockdown_122_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.6447
epidermal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.0728
LE-40-JW92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.483695
A549_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184646
indapamide-3859	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
HNF4G	ENCODE Transcription Factor Targets	1.0	null
GSE138938_1_v_3_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ESR1-20056654-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
fatty acid omega-hydroxylase activity	GO Molecular Function Annotations 2025	1.0	null
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.900842
hippocampus (hippocampal formation)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.27254
hsa-miR-149	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
heliotrine-4739	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_MCF10A_48H:I06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3406
GTEX-WFJO-0008-SM-4LVN7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE222758_0_v_1_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H446	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.826956
Oxidation by cytochrome P450	WikiPathways Pathways 2024	1.0	null
BRD-K20068050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16083
ERBB3_drugactivation_31_GDS4361	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.67488
CRCGN016_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.40444
BRD-K88720906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18984
blood	GTEx Tissue Gene Expression Profiles	-1.0	-1.6023
BRD-K16954129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04897
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE210093_0_v_2_taf15_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6481
ETV2::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9515
HCMV_24Hour-AG_pretreatment_20173022_GSE17948	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.3267
A549_PFI-1_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138068
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GATA3	ENCODE Transcription Factor Targets	1.0	null
BRD-K76600600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54899
GTEX-PLZ5-0926-SM-3TW8L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35271
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18686
quinone catabolic process	GO Biological Process Annotations 2015	1.0	null
COPD - Chronic obstructive pulmonary disease_Lung Tissue_GSE1650	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.55364
hemostasis	GO Biological Process Annotations 2015	1.0	null
ETV5::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9999
NCIH1435	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3906
calcium pantothenate-4189	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
H3K4me1_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4683	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065576
FOXA2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	79.6498
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054321
FOXA1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0826-SM-32PM4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
duodenum_4b	HPA Tissue Sample Gene Expression Profiles	1.0	0.897885
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
H3K4me1_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MAFF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QCQG-0626-SM-48U21	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16032
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00308
BRD-K04722226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58807
CRCGN013_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1562
digestive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05424
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QCQG-0526-SM-48U2A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02074
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.047136
inferior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.94619
GTEX-TMZS-0008-SM-47JWM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
18631401-TableS3	GeneSigDB Published Gene Signatures	1.0	null
NR3C1	ENCODE Transcription Factor Targets	1.0	null
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.01158
GTEX-S32W-1926-SM-4AD63	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74634
hsa-miR-4674	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
NB1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-A24396574_celastrol_MCF7_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5324-01A-01R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-S7SF-1926-SM-4AT5B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.971811
CRCGN009_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12184
GSE146982_3_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SJXC-0226-SM-2XCDU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
BRD-K72192970_ST019365_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE147876,GSE147877_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_CEP-33779_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165752
Ethoxzolamide	DeepCoverMOA Drug Mechanisms of Action	1.0	1.56
GTEX-N7MT-1926-SM-3LK5N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939759
Colon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
diperodon-6836	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.296
menaquinone catabolic process	GO Biological Process Annotations 2023	1.0	null
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74754874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43189
H3K9me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-VUSH-0008-SM-47JWK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
MV-4-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.869511
parasubicular cortex (parasubiculum)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.94855
NADP	HMDB Metabolites of Enzymes	1.0	null
GTEX-S7SE-0226-SM-2XCD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
FOS::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.944
ARPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08953
HUP-T3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48625
BRD-K35156336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5451
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.72272
H3K27me3_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-95-7043-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K19418944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09714
GSE210662_2_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KDM5A	ENCODE Transcription Factor Targets	1.0	null
BRD-K91506006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23822
Hyperglycemia	CTD Gene-Disease Associations	1.0	1.06917
jnk	GeneRIF Biological Term Annotations	1.0	null
CRCGN015_MCF10A.WT.HP_24H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.8988
GSE228017_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	1.0	null
piretanide-3567	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
phthalylsulfathiazole-5249	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T8EM-0626-SM-4DM62	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5190-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XPT6-2126-SM-4B66P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.882659
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MB-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SKG-IIIA	COSMIC Cell Line Gene CNV Profiles	1.0	4.51153
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
GSE230744,GSE237803_0_v_3_hira_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8586238-41467_2021_26788_MOESM6_ESM.xlsx-S2A_CDE_genes-S2A_CDE_-_genes_of_the_two_CCD_genes_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
oxybenzone-5410	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_17665_OE_RAB44_SRP305964	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE146982_0_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MIAPACA2_PANCREAS	CCLE Cell Line Proteomics	1.0	2.70704
496100315_TCx_no dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.57008
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61H-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular catabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K51608472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.553
Fetallung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.31492
H3K4me1_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
adrenal_4c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
BRD-K19523047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15432
SCCOHT1	DepMap CRISPR Gene Dependency	1.0	2.53824
clebopride-5412	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hacat	GeneRIF Biological Term Annotations	1.0	null
GTEX-PLZ6-0008-SM-48TD5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07657
skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063837
hsa-miR-4755-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
M07E	DepMap CRISPR Gene Dependency	1.0	2.01541
KCL22	CCLE Cell Line Gene CNV Profiles	-1.0	-2.16858
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11772884-41421_2024_747_MOESM6_ESM.xlsx-7_DEGs_USF2-KO_vs_control-Gene_Symbol_USF2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K34858602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64672
PMC8350598-NIHMS1728503-supplement-Table_S3.xlsx-Upregulated_by_SMAD4-Gene_Symbol_SMAD4	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Diseases, Viral	HuGE Navigator Gene-Phenotype Associations	1.0	null
FOXA1_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7782_KD_ASCC3_SRP023199	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
A549_Capecitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143233
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162066
CRCGN017_MCF10A.TP53.M_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.64817
SW 1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.69249
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050824
CRCGN017_MCF10A.TP53.M_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27023