association	dataset	threshold value	standardized value
GSE140997_4_v_3_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AF-12-IW93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.851237
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	84.2112
SPIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.2804
CNOT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88225
MAP1LC3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44186
pancreatic islet	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.495309
DE-05-NX87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239061
KBTBD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60327
hsa-miR-4695-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
JB-01-MH79_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.282563
TAOK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94613
hsa-miR-1912	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Perturb_8881_KD_CSL_SRP142324	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.16091
CRCGN011_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22115
CRCGN008_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6168
myeloid progenitor cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BC-01-JL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23843
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5758
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RA-49-ZB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.530656
BC-45-VY95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222036
E2F7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8379
2203_DHX15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.610628
CHN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48685
PPM1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89321
GA-79-ZF28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.417125
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.615938
ZNF594	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50988
PA-TU-8988S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.858579
Perturb_7298_KD_PCIF1_SRP162223	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.67883
anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.839283
GB-37-WI36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214938
Sarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.262
HEY1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8101
XB-35-TO54_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.376494
EWSR1-FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	120.619
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05951
GSE242555_1_v_0_fn3k_human	RummaGEO Gene Perturbation Signatures	-1.0	null
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.990539
Perturb_11736_OE_KLF5_SRP091857	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03544
ME-31-RM40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.383963
chr22_23969398_GC_G_b38	GTEx eQTL 2025	1.0	1.41497
Perturb_4760_KO_DLG2_SRP315088	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
negative regulation of leukocyte chemotaxis	GO Biological Process Annotations 2025	1.0	null
PMC11392820-41556_2024_1475_MOESM3_ESM.xlsx-Supplementary_Table_9-Supplementary_Table_9_Expression_level_of_OTX2_targeted_genes_n_999_related_to_Figure_6_OTX2	Rummagene Transcription Factor Associations 2026	1.0	null
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.961
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PAX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vesicle	GO Cellular Component Annotations 2015	1.0	null
PC-18-VX23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.665293
intracellular part	GO Cellular Component Annotations 2015	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-8153-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Tendril	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.903
AC-71-YF45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.362816
ZNF345	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83371
Perturb_9062_KD_POU5F1_SRP100928	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-14.5702
CRCGN013_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.75438
AE-73-KX58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246554
THRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	99.4457
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.986344
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3436-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PTRH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43592
VDR	ChEA Transcription Factor Targets	1.0	null
CA-60-LK14_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277285
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65J-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4130-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MEF2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29053
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-3139	TargetScan Predicted Conserved microRNA Targets	1.0	0.436802
Perturb_7387_KO_UPF3B_ERP130413	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.40165
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245509
MD-49-BL92_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.373522
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.669605
PB-13-ZD03_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.10078
G3BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20564
RIPPLY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62732
Perturb_6716_KD_NAA40_SRP308012	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.81583
GSE195568_3_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_7149_KD_HBS1L_SRP070129	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.77077
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.39665
AA-48-GT70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.326956
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
BE-48-TM93_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.507
SOX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2542
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.937236
Perturb_2567_KD_HMGCR_SRP216293	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.97059
B4GALT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83391
adult retina	HPM Cell Type and Tissue Protein Expression Profiles	1.0	1.14787
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A3-11A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE144347_1_v_0_crnkl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SRSF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5768
S0-EE-XFDA_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227263
DA-01-GV68_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280223
SPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48728
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8144_KD_PABPC4_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.88252
JUN	JASPAR Predicted Transcription Factor Targets	1.0	null
ZC3H12B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96796
TE5	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48736
Perturb_7291_KI_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.10397
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H0-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMYD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3497
CHCA	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
Perturb_3524_KD_TASOR/CNOT1_SRP337789	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.0516
AC-79-CQ25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267819
PEX14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0835
DD-42-PC65_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207152
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
VTA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.57363
Kidney renal clear cell carcinoma_KIRC_TCGA-MW-A4EC-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7870-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_482_KD_IFI16_SRP298943	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.5123
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.341204
BD-46-RY02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.328612
2134_DDX5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.6445
CTCF_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YC-57-OY42_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20817
ED-81-ZH14_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.350357
blast cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HIF1AN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14777
CRCGN010_HEPG2_24H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10771
VC-30-QH05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.305846
UA-39-TN76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251474
FARAGE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.97505
Perturb_8445_OE_GSTZ1_SRP155565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.07743
CRCGN015_HEPG2_48H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.56923
GUSB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42757
KMS21BM	CCLE Cell Line Gene CNV Profiles	-1.0	-2.21039
Perturb_6680_KO_SREBF1_SRP255872	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.3053
LC-57-RH78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.337152
TEAD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15318
KHSRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.90412
BB-82-TP51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.252138
CTCF_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
B-lymphoblastoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.254
1842_CPSF3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.647949
DC-43-KF54_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.788821
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BF-97-LS55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227481
VPS35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21934
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_17242_KD_IRF1_SRP337933	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.15286
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19108
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Perturb_15141_OE_LINC00473_SRP257261	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.87528
COLO 800	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.952506
BB-87-SF89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.547856
Perturb_8916_KO_KDM1A2a_SRP348808	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.3794
QF-00-CY91_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232803
AF-81-IV73_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.307671
GSE135350_3_v_5_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.181
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.557661
TAF5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89064
EF-14-GN61_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.284601
Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CE-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.925058
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.0764
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221181
NR1D1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.6778
Perturb_10234_KO_FAM120A_SRP384156	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.50361
Perturb_11368_KD_MAP3K7/CHD1_SRP310158	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.52446
SB-94-ZA83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236985
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7376_KD_RBM39_ERP105778	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.54823
3869_HNRNPK_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.644351
Acute Myeloid Leukemia_LAML_TCGA-AB-2956-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
interleukin-10 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.589
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.27279
MCF7_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135087
CTCF_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CB-99-OG76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.322431
EA-41-GV68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217673
BF-10-IO69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218746
Perturb_9830_KD_USP7_SRP256243	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.6958
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.93911
Rab-protein geranylgeranyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.707
hsa-miR-4700-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
UACC893	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.846665
ANGPTL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34399
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-let-7d	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
JUND	ENCODE Transcription Factor Targets	1.0	null
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.893366
chr22_24000597_C_T_b38	GTEx eQTL 2025	1.0	2.40532
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23542
GABPA_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Vas deferens	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.912
GSE158834_7_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-09-JN93_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205588
BA-09-ZX42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270887
CRCGN011_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8644
SPI1	ENCODE Transcription Factor Targets	1.0	null
Perturb_6420_KD_SPRY4IT1_SRP347515	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.00663
LIMK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97895
FF-01-OH44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.314205
SEZ6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19089
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A267-06A-21R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.35765
S0-EE-YEKU_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204858
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06929
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7907
CAPN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30982
GSE216043_10_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
455_ARGLU1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.7434
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.30238
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051478
BD-26-EO58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.354235
hsa-miR-3938	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GB-96-WX99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307469
GSE102505_6_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.11156
posteroventral (inferior) parietal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.37307
Sarcoma_SARC_TCGA-DX-A7ER-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.893366
kidney	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
AA-62-HP31_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.875526
RUNX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.4772
JF-39-BZ76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249135
Lalistat1	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	83.8589
Runx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.8405
PMC11252405-41467_2024_50426_MOESM4_ESM.xlsx-Fig_S4c-CTCF_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
positive regulation of defense response	GO Biological Process Annotations 2025	1.0	null
Pparg::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.8727
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-14-CG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.490615
FRAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48679
hsa-miR-663	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
ventrolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.824364
KF-18-RY71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.529831
Pollen mother cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.751
Perturb_11531_KD_THOR_SRP121007	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
1570_CHERP_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.733279
MCF7_CUDC-101_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118837
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.4257
metabolic process	GO Biological Process Annotations 2015	1.0	null
AA-58-FJ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.523959
MED15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7141
CD-08-MF16_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243938
ARL4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33912
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BA-68-FJ41_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221003
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61I-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JC-14-YI23_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22037
UF-28-DW05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205858
Acute Myeloid Leukemia_LAML_TCGA-AB-2910-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DA-20-VR86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300948
VF-20-LY76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290002
Perturb_677_KO_SLC15A4_SRP212091	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.54393
PMC7098486-mmc2.xlsx-Kgg_Quant_NGN2_AAVS_-_WCL-Unnamed_2_NEUROG2	Rummagene Transcription Factor Associations 2026	1.0	null
BC-94-GN01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.471569
hippocampus (hippocampal formation)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00294
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NR3C1_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.958816
SMARCB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.57934
skeletal muscle	HPA Tissue Protein Expression Profiles	-1.0	-0.793526
GSE258991_5_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
OC-71-BZ81_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.306557
EF-75-JG46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.440866
AA-23-FM46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305766
APBA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.64196
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YL-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157628
ZIC5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	111.549
DLX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88418
Perturb_14153_KO|KD_KBTBD4|RCOR1_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE140997_4_v_6_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CA-39-ZJ18_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254054
GSE149035_7_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
8185_SMNDC1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.515461
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	161.716
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.8843
GSK429286A	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
Acute Myeloid Leukemia_LAML_TCGA-AB-3005-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14128_KD_AKR1B1_SRP400403	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.99585
ARMC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67096
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39W-11A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JC-96-ID26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.252654
Perturb_9064_KD_POU5F1_SRP100928	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.9159
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.2141
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.15736
AC-17-PI61_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259198
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PD-05-HV36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.49179
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.619187
AB-84-PK04_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.500653
BE-59-WG31_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254273
CRCGN017_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.11732
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.820085
AD-41-WB70_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201889
TC-95-IR96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202446
A549_BMS-536924_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132104
ZNF135	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	79.1561
fetus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ZNF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.8739
NCOA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8971
JC-14-YI23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229556
KYM-1	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.15836
FF-01-OH44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.275679
CAL-148	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.05472
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YQ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7425_KD_RBFOX2_SRP045481	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BB-52-LF37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210255
QF-00-NO42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.78949
CF-02-MS93_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.362501
Perturb_11948_KO_LYCAT_SRP257777	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.73066
EA-18-FP00_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.15445
CRCGN015_MCF10A_48H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19273
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JF-39-BZ76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302955
GE-98-ZI68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.80202
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.166
RN-1734	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
CA-96-UO48_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.256159
hsa-miR-1207-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
CRCGN009_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.994
CRCGN015_MCF10A_48H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11481
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.24541
Acute Myeloid Leukemia_LAML_TCGA-AB-2856-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CLDND2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27787
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.7681
forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
8238_SNW1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.2221
POU1F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4818
GSE154577_13_v_5_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_A-366_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124202
KA-71-CQ25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.447555
ZSCAN16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8637
CNPY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19823
CE-72-GF32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200371
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
LF-27-NX16_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235879
Perturb_17617_KO_TIP60_SRP386872	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.30652
GSE182680,GSE182683_7_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-8601-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A3R2-11A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PYCR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65169
CRCGN015_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8948
Perturb_9007_KD_ETV6_SRP273428	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.91904
AA-23-FM46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.310538
CRCGN017_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.20445
A549_Selisistat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152545
SELENBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2134
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06821
BC-82-PP66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.57534
GSE189859,GSE189861_0_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN015_MCF10A_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0184
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.93941
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.3225
Lung adenocarcinoma_LUAD_TCGA-55-8506-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RXRA::VDR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.3
GTF3C3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38136
TMEM175	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92331
SW 1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.877282
Perturb_7397_KD_DHX38_ERP132987	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.32683
BE-46-FY47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.252083
chr22_23938500_C_T_b38	GTEx eQTL 2025	1.0	1.13598
Stichosome	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.642
heart	GTEx Tissue Gene Expression Profiles	1.0	1.34477
Perturb_4852_KD_ZNF503_SRP059197	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.75634
WB-82-EL69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.350301
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.17873
DD-64-ET45_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.256496
Lipopolysaccharide receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.571
MCF7_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137719
BB-20-UU03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.327869
EF-74-KW12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322271
UF-27-OP66_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213305
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.983284
XPO1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_15023_KD_RelA_SRP078053	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.1991
BS-181	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.45
Adipocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.218
PK-45P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02157
MAF::NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2385
GE-34-TW62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.316018
PAX5_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.5502
DES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26508
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19C-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
QE-79-XO29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.330099
HA-38-ML65_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.368639
PMC11906354-41588_2025_2087_MOESM4_ESM.xlsx-ST12-Unnamed_3_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
FOXA2	ENCODE Transcription Factor Targets	1.0	null
GB-31-HY20_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.503965
SB-80-CR34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.317402
GF-92-IR00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214149
Lung squamous cell carcinoma_LUSC_TCGA-85-8052-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KF-38-DH25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213128
GD-90-RA90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246766
Perturb_14373_KD_IGF2BP1_SRP150935	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.31361
Hepatopancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.623
CRCGN009_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.51744
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.8802
VEZT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39474
CTCF_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MFAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01212
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00174
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A3MB-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LETM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42206
APOBEC3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3924
ZSCAN29	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.2004
PMC9530161-41419_2022_5296_MOESM2_ESM.xlsx-Tab10_KDM5C-KD-up-DKD-rescued-Table_10_Up-regulated_genes_in_KDM5C-KD_and_rescued_genes_in_DKD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
LA-09-SS14_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254181
KYSE520	CCLE Cell Line Gene CNV Profiles	1.0	2.89198
BRSK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35871
Nutlin3a	DeepCoverMOA Drug Mechanisms of Action	1.0	1.12
Metacestode	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.536
KD-86-AJ75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.362462
GSE207514,GSE207515_1_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
S0-EE-YNU4_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204889
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5J6-01A-31R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SA-31-VB03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285236
JD-04-UT85_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230311
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	98.6249
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BB-33-HC27_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224684
BA-84-TD72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.472789
AB-00-IL62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.4268
PUR1	MotifMap Predicted Transcription Factor Targets	1.0	null
TPRX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.62218
Lung squamous cell carcinoma_LUSC_TCGA-58-8387-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AD-55-HH69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204907
GF-32-FY02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299939
ZDHHC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5661
PANC 03.27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00174
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.961655
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.893366
primary motor-sensory cortex (samples)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1038
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00174
BA-09-ZX42_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269934
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BB-79-AG41_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.776185
KC-15-HM70_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.273773
ENSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95037
NKRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93395
YC-57-OY42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244874
hsa-miR-3160-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
BE-45-UU35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.624021
Liver hepatocellular carcinoma_LIHC_TCGA-KR-A7K8-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202434,GSE202438_9_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.572204
BE-46-FY47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257055
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SURF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39421
POMGNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21545
ERCC6L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.68397
BD-93-AM31_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.343284
LB-76-JJ80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254891
Msgn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.9114
CA-17-XB39_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30039
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.64548
ED-98-UI13_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.646257
chr22_23945520_G_C_b38	GTEx eQTL 2025	1.0	2.46098
USF1_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSC3	CCLE Cell Line Gene CNV Profiles	1.0	1.45236
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleotide-excision repair factor 3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.109
Perturb_7871_KD_PCF11_SRP258098	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.63367
OC-41-DF58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.399627
CA-26-BI29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.454652
LF-86-EA69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206355
GSE210101,GSE210114_2_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.34334
Perturb_7590_KD_GEMIN5_SRP368027	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.93377
DB-33-HZ87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.756374
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.818455
hsa-miR-4685-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
3871_HNRNPL_P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.552915
Perturb_7392_KO|KD_UPF3A_ERP130415	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.14979
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.88807
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6V7-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE232558_0_v_2_fbxl12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KIF20B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52762
Perturb_12676_KO_PTPN2_SRP108032	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.80522
IA-65-QX27_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.402
GD-90-RA90_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.369671
SLC66A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40937
GSE211128_9_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AA-83-YJ04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.52369
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A8OD-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ED-98-UI13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.4729
1408_CDC5L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.656038
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.885617
EF-19-KJ63_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223054
WA-15-KX40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.936021
Adrenocortical carcinoma_ACC_TCGA-OR-A5LE-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.937236
RER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35235
Perturb_11960_KD_RAD6B_SRP258673	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_14202_KD_KLF5_ERP117894	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.61776
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3256
EBF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17241_KD_IRF1_SRP337933	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.96766
NRIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95365
S0-EE-YFM9_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.507032
NF-21-HQ00_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20651
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.239
GSE209601_2_v_1_mef2a_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZD-18-MI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27377
ME-54-JY76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.387943
Liver hepatocellular carcinoma_LIHC_TCGA-ES-A2HT-01A-12R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BATF	ENCODE Transcription Factor Targets	1.0	null
HC-96-WV85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231441
EPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20951
CRCGN017_MCF10A.TP53.M_24H:F23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05328
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.55715
AC-54-FR31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.395578
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.2201
EC-96-OH91_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261886
Perturb_3632_KO_HDAC8_SRP355605	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.37089
ZNF334	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7893
OCI-M2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.50875
Nitrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.682
phenylpyruvate tautomerase activity	GO Molecular Function Annotations 2023	1.0	null
GSE183327,GSE183328_1_v_0_ddit3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BB-69-WN73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209738
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.79293
VF-07-NP76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240318
YY1	ENCODE Transcription Factor Targets	1.0	null
IF-87-AU84_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.256355
CE-15-YU05_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.783303
PB-09-OE00_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228062
FOXA2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.683
RB-74-JO32_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214121
MCF7_Entacapone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126732
ZB-16-BR73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.464586
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.53916
anterior (rostral) cingulate (medial prefrontal) cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.70896
DNAJC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08599
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RA-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Octreotide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.22
AC-54-FR31_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.489889
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.796808
BB-58-LW82_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299946
SC-72-YW56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.365914
FA-16-HR75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24438
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.47505
DEDD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67255
MYH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12426
CRCGN017_MCF10A.TP53.M_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06503
Perturb_14200_KD_HNF4A_ERP108557	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.00966
GSE227592_13_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
HF-79-EC41_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.255994
PBX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
B-lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.254
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265134
UTP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77894
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.4187
Head kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.754
JD-70-IC84_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202191
OC-15-PM40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.392756
Lung adenocarcinoma_LUAD_TCGA-NJ-A4YF-01A-12R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
DE-60-SD92_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.318428
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A4AV-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GA-94-MC54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.526109
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222013
GSE128730_3_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EE-04-QG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286889
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.49436
Brain Lower Grade Glioma_LGG_TCGA-HT-7684-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.847879
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.3298
cerebral cortex	HPA Tissue Protein Expression Profiles	-1.0	-0.793526
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9644
PDZD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.27929
TAF1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterus	GTEx Tissue Gene Expression Profiles 2023	1.0	0.672675
DF-93-BT88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.595904
BE-48-IT75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.620874
DTX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25308
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3885_KD_EIF2B5_SRP124930	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.1165
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6216
Perturb_8284_KD_CSTF2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.00042
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.6332
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.76616
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.335749
Rh-18 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.788
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GPR108	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42444
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3401
ZB-72-PE17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.0769
NE-92-EU87_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.558271
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28157
WC-33-YP46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.364969
ANKRD13D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35183
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.610076
DE-98-FC24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.506049
FF-34-KW62_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.408441
C11orf54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68694
positive regulation of tumor necrosis factor production	GO Biological Process Annotations 2025	1.0	null
PLEKHG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87973
GABPA_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nes	HPA Cell Line Gene Expression Profiles	-1.0	-1.85454
AC-84-QG99_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.525
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1059
GSE158834_2_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hFOB 1.19 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.896
GB-84-KP45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237305
SB-80-CR34_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.482824
HA-81-VN33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.752188
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227297
OD-28-MX63_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219724
3086_FIP1L1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.608377
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2387
COL2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34989
CAL78	CCLE Cell Line Gene CNV Profiles	1.0	1.38298
KD-31-TU05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.885033
HC-63-SV27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232769
Perturb_8069_KD_SFPQ_SRP281189	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.73408
chr22_23993034_C_A_b38	GTEx eQTL 2025	1.0	3.8256
Ppara	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.6422
Perturb_2334_KD_SON_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.21169
BB-23-PM31_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254812
Perturb_8787_KO_HNF6_SRP217514	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.3989
CRCGN016_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.74944
WC-33-YP46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.638572
Perturb_270_KO_ADIRFAS786_SRP366780	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.22401
CB-24-FA25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247388
DC-22-HS83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237296
SIN3A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.19301
A549_Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156743
Perturb_15505_KD_CDK7_SRP179971	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_7150_KD_SKIC2_SRP070129	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.82986
ED-81-ZH14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.312392
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Renal proximal tubule epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.561
LAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81695
DA-59-ZD74_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.416171
chr22_23971817_G_T_b38	GTEx eQTL 2025	1.0	1.62161
BA-97-CI76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.331528
Macrophage migration inhibitory factor, conserved site	InterPro Predicted Protein Domain Annotations	1.0	null
Perturb_12492_KD_PELP1_SRP351131	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.42788
EIF4E3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94369
AB-64-NN66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210869
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.092
positive regulation of MAPK cascade	GO Biological Process Annotations 2025	1.0	null
kidney_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.41881
Perturb_8133_KD_EIF4B_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.96233
CRCGN009_HEPG2_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.553
CRCGN017_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03725
AC-31-SL44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.273664
HF-36-FK93_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.48174
ZIC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45058
GSE186471_1_v_2_carnosol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5891-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.863567
ventrolateral prefrontal cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.25882
Perturb_9137_KD_HMGB2_SRP106038	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.5875
GSE135514_2_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-98-UM13_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290297
CC-61-KS26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.411991
KB-37-OO25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.563119
HCMEC/D3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.543
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281726
TD-69-UA90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.276049
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4154-01A-01R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CC-14-WK34_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247787
urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TRMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.9685
USF2	JASPAR Predicted Transcription Factor Targets	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5886-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EE-61-NU30_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214289
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9617
GSE222758_0_v_3_clofazimine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Basal node	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.958
MRPS33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93429
extracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BF-59-OR93_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.458255
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45W-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7379_KD_SMG5_ERP122822	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.40204
CRCGN015_MCF10A_48H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10712
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39V-11A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LD-69-ZV56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.675592
CRCGN015_MCF10A_48H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13687
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.61334
CD-35-BD44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.42181
6026_PABPN1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.1443
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9671
Ivacaftor	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.7
Perturb_16814_OE_HNF1A/FOXA3/PROX1/SIRT1/PGC1A/AMPK_SRP167105	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.1163
GSE130715_2_v_3_budesonide_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC1937	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.819053
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22026
Perturb_13870_OE_LMO1_SRP093679	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.52107
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.8287
JD-87-MR82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201378
GSE228106_3_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235390_4_v_2_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FF-35-JG06_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201182
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09036
CRCGN017_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1149
CF-22-OS28_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.423059
WWC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04197
BE-46-FY47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.509365
MSX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26689
Perturb_9063_KD_NANOG_SRP100928	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.8197
ZCCHC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00722
Leaf base	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.723
NCIH1836	CCLE Cell Line Gene CNV Profiles	-1.0	-1.84502
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.31598
GSE119978,GSE180930_3_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65D-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RC-21-IF98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.315254
FARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87493
Blood platelet	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
600MPE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.65377
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
LC-96-WR85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.377341
CC-91-RO81_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.352355
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
IB-34-OS52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228605
Perturb_9835_KD_GCN2_SRP248465	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.41116
GSE105170,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TA-20-FO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205716
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5880-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.855012
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.6368
CD-08-MF16_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.328936
hsa-miR-4528	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
BB-86-BE39_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247291
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10208
PA-15-CI45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302118
CE-35-LA42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.06306
Perturb_8925_KD_H3F3B_SRP350008	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.34744
TC-95-IR96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24936
Brain Lower Grade Glioma_LGG_TCGA-HT-A4DS-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9970_KD_WDR43_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.32755
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056208
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
OB-78-PA58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.327516
GA-09-TM90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.283726
AD-18-XC14_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.4847
BA-96-YB32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.692501
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8246_KD_CCAR2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.95841
DXO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66661
ventrolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11345
GSE127261_1_v_2_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.629
Perturb_6602_KD_HOTAIRN_SRP159657	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.1139
CF-22-OS28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.407444
Lung adenocarcinoma_LUAD_TCGA-50-5066-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BF-44-HD37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265052
JF-30-FW92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.356717
CRCGN009_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.15673
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN016_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.17925
ELK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.81101
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.9478
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.911522
PC-87-OG75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.796554
hsa-miR-520a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19081
colonrectum_f	HPA Tissue Sample Gene Expression Profiles	1.0	1.08591
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MRPL32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37707
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4451
urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ID-26-HX79_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.454914
VF-07-NP76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238203
hsa-miR-2110	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Perturb_8883_KD_CSL_SRP142324	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.03556
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.434899
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ALDH1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85785
MAP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.43065
GSE135030_11_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
FE-12-TO68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.453335
INSIG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9587
RORC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8174
CHP-212	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05961
VD-76-SO91_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.632774
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8072
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZU-06A-12R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ADCY7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32875
TK-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00368
USF1	ENCODE Transcription Factor Targets	1.0	null
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35131
GA-87-BR97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.324867
CB-82-BV25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224196
Edema	HuGE Navigator Gene-Phenotype Associations	1.0	null
NPM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88296
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.822
Heart ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.652
REST_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_12293_OE_RORC_SRP066204	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.78325
POLR2G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08992
Perturb_11403_KD_CPT1A_SRP076884	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-18.0269
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.3063
CA SKI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.77086
SHMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.235
3857_HNRNPA1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.612082
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE155567_3_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216043_11_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GF-57-LR72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.394407
GD-79-JJ38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.389366
GSE185519_4_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Tucidinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160002
AC-55-XA97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.48627
BD-65-VV48_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.322837
KLF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	87.9539
XRN2	ChEA Transcription Factor Targets	1.0	null
GF-32-FY02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220893
NTMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83647
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.494694
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.76587
AD-98-UM13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239889
Perturb_13017_KO_ALOX5_SRP367905	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.98659
GSE102467_1_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6404-02A-21R-A36H-07,TCGA-DU-6404-02B-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_3908_KD_ALDH1A1_SRP164778	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.95349
GSE126463_1_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_8018_KO_PXR_SRP257678	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Lung adenocarcinoma_LUAD_TCGA-62-A46O-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Middle ear	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.959
PRB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17076
Perturb_2136_KD_ARVCF_SRP186778	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.98974
GA-09-TM90_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265526
AB-92-GP61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246788
PF-72-IT39_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.296771
GSE172016_2_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
KNS-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.72708
DC-08-CM08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.659306
XB-75-YN01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212912
Headfoot	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.621
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.17249
CRCGN015_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.8631
kidney	HPA Tissue Gene Expression Profiles	1.0	1.06166
ED-71-GA72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245257
CTCF_GM20000_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1160_KD_CELSR2_SRP149837	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.07984
Perturb_2374_KO_ASXL1_SRP305063	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.06942
FA-72-JL16_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201732
BC-88-KT45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.306085
ABCA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35918
FOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23781
HF-91-IU60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212936
JD-44-KF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.760327
CCDC163	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.155
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.79631
FD-35-PQ00_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.365771
Velocardiofacial syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.228
cellular_component	GO Cellular Component Annotations 2015	1.0	null
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.0993
smooth muscle	HPA Tissue Gene Expression Profiles	-1.0	-1.26579
EC-87-ZE76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.331808
UC-00-QA88_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235481
QA-25-HL62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233147
Perturb_8885_KD_FOXM1_ERP109084	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.65452
Left ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.652
Brain - Putamen (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	0.497736
RB-80-RO52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.315936
HC-01-FD24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.355044
Icatibant	DeepCoverMOA Drug Mechanisms of Action	1.0	0.22
AE-19-BK71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249637
VILL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41239
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.778557
DEOC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.04639
MCF7_Dacinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0098062
NPIPB11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12422
ENO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5281
hsa-miR-136	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U7-06A-21R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Ofloxacin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134371
KC-67-HN97_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.372839
Perturb_2716_KO_TET1_SRP110516	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.35538
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GC-29-JC76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.528991
AC-58-RM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.331865
Extracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GD-96-AK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.365487
KB-37-OO25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.331121
GSE80098,GSE80366_0_v_5_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
XA-39-SG64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232948
Perturb_10403_KI_LAMC2_ERP136718	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.93445
ZNF775	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1735
SLC29A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52274
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SG-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HE-15-UQ55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.553742
ZNF383	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74839
GSE211128_7_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6147
chr22_23945481_C_A_b38	GTEx eQTL 2025	1.0	1.19611
POLR2A	ENCODE Transcription Factor Targets	1.0	null
CHEK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18123
NCIH2085	CCLE Cell Line Gene CNV Profiles	1.0	2.00652
Perturb_7248_KO_LEF1_ERP109990	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.04714
DB-88-VW47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.20713
GB-27-AY54_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.366066
Mitochondrion	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.986
YE-01-JU83_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.278283
MITF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9712
Perturb_10034_KD_PUF60_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.38858
GSE213588_10_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242555_1_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
1972_CWC22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.626216
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0087
OC-41-DF58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.298217
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8188_KD_HNRNPC_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.80021
CRCGN017_MCF10A.WT.HP_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.4875
HC 067047	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
NS-0 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.817
1349_CCT5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.539789
ZNF513	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77853
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_LNCaP clone FGC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2764_KD_FOXA1_SRP077334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
AC-65-TK51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.542338
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06821
NE-92-EU87_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.41402
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.834899
FD-35-PQ00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.370583
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H2-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_8168_KD_GRSF1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.68441
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A5PC-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HC-76-SY22_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307544
AC-55-XA97_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263037
EE-98-PF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200623
DAUDI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.887351
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	131.497
TMEM89	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03554
RBMX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44075
CCZ1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.68438
HA-22-CY42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.284625
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3451-01A-02R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PB-13-ZD03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.873647
FA-72-JL16_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299612
WA-15-KX40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.761418
FHL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26441
Coffin-Siris syndrome 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.539
Perturb_598_OE_HOTAIR_SRP342161	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
DD-44-OX00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.426267
EGR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16201
GSE147876,GSE147877_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.26604
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.977988
PC-62-AQ92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.07665
Perturb_14745_OE_MEOX2_SRP330486	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.8418
GE-01-QX17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293426
Perturb_7855_KD_E2F7/E2F8_SRP212181	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.27572
CRCGN010_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1164
Intrinsic component of organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.148
GSE126463_1_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PFDN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	6.27682
Lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.254
SP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	97.8292
Perturb_15634_KO_AHCY_SRP351305	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.29481
BB-82-TP51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2253
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
ARPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54931
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WQ-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF512	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89073
CAAX-protein geranylgeranyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.893
CB-99-NG16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232717
SULT1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91906
FB-67-PL18_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203225
Perturb_11542_OE_KRAS_SRP175175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.26934
Teijin compound 1	DeepCoverMOA Drug Mechanisms of Action	1.0	0.29
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.25236
ARHGEF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30083
BF-76-AO03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245418
Lung squamous cell carcinoma_LUSC_TCGA-22-4613-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42882
MCF7_Cerdulatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016421
1441_CDK7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.800624
NCI-H2373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.67941
RFX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76958
FKBP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59126
S0-EE-XMWH_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.325844
AB-00-VH52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230818
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.989486
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06908
Lung adenocarcinoma_LUAD_TCGA-97-8171-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_IOX2_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131341
GSE188570,GSE188571_3_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CARMIL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05381
MCF7_AG-490_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197364
SE-89-DO49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202095
GB-33-SS25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.421078
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.48034
CD-20-MH57_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215424
DB-40-GN91_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225526
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-564	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
CHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.883287
Cloned cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.659
MCF7_Roscovitine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135458
HNRNPA2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43129
Brain_Hippocampus_Middle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-2.73075
GSE223241_2_v_0_cdkn2a_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-4458	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
BB-37-LS05_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.723951
Lung adenocarcinoma_LUAD_TCGA-55-7903-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.505979
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.957349
GA-51-DD14_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224206
WA-03-IF37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238679
Preadipocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.332
JHH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06929
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
S0-EE-Y79N_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.341219
Inflorescence stalk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.725
MRPS23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.85444
6119_PCF11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.578045
FLNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40881
PC-63-CH43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267123
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.1344
BB-48-VW67_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237971
C17orf107	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27304
DC-84-GJ21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300882
RGS16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27163
Perturb_15022_KD_RelA_SRP078053	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
CRCGN017_MCF10A.WT.HP_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7122
MKN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03053
NC-73-QU79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.363729
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.2961
GSE165334_2_v_0_dabrafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CAL120	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58243
hsa-miR-1	MiRTarBase microRNA Targets	1.0	null
NUGC4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40641
EC-87-ZE76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.256178
amygdaloid complex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.32066
Lung adenocarcinoma_LUAD_TCGA-49-4514-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
2774_EWSR1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.589522
KLF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.0121
Perturb_676_KO_SLC15A4_SRP212091	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.72083
GSE147876,GSE147877_2_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RAB5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.56732
HMGA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92689
CB-88-LG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292728
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EC-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BOLA2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3362
CYTL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46252
6460_PLRG1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.519884
RD-57-WQ44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.29056
TXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79591
MNT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39309
CCT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16193
Lung squamous cell carcinoma_LUSC_TCGA-85-A4CN-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Thalamus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.86406
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.3278
PMC11233907-mmc8.xlsx-S7-Table_S7_Heterogeneity_Analysis_and_Egger_Intercept_Test_for_MR_Hits_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FGFBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.54187
Vagina	GTEx Tissue Gene Expression Profiles 2023	1.0	1.13469
RPS12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.4681
GD-51-SU60_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258255
KC-97-AA46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258844
WDR35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33564
DD-10-NA60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.255531
Excretory gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NELFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52347
FD-88-CF51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.363652
Brain Lower Grade Glioma_LGG_TCGA-DH-A669-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KP3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37689
HDDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76181
GSE158834_2_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ABC1	CCLE Cell Line Gene CNV Profiles	1.0	2.35688
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CCNE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04909
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78O-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DA-17-XI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.26592
Lung adenocarcinoma_LUAD_TCGA-78-8662-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CORL23	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43342
CA-68-KG29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218374
ATG16L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4651
Rarb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	79.5676
Perturb_11350_KD_NFAT1_SRP173011	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
EIF3K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32208
RA-49-ZB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290392
BB-20-UU03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.444522
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.78701
SLMAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30909
SPI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_0_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HD-89-HC56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224705
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BE-74-SX40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.276707
Perturb_2521_KO_HSF1_SRP341615	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.32684
JC-64-QI43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209965
PINX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46738
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.895468
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.841898
TPD52L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17606
GSE140997_4_v_8_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
WB-54-WD35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.409448
Perturb_8092_KD_PUF60_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.95505
CA-96-UO48_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247933
Prostate adenocarcinoma_PRAD_TCGA-J9-A8CN-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KYSE410	CCLE Cell Line Gene CNV Profiles	-1.0	-1.52594
IA-35-KC86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.620086
ID-26-HX79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.373526
GSE146612_1_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
MC-40-IP75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311112
HA-48-LV39_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203827
EGR1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CNOT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64595
Head and Neck squamous cell carcinoma_HNSC_TCGA-TN-A7HI-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
extracellular vesicular exosome	GO Cellular Component Annotations 2015	1.0	null
EF-22-PB37_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23991
A549_Ivosidenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179099
QC-12-DW06_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.315843
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.858579
NCIH1869	CCLE Cell Line Gene CNV Profiles	1.0	1.77179
Perturb_10026_KD_TRIM56_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.69723
8366_SPOP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.536297
CRCGN017_MCF10A.WT.HP_24H:O09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6768
Lung squamous cell carcinoma_LUSC_TCGA-85-A4QR-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EF-14-GN61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.287507
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMEM178A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32304
G402	CCLE Cell Line Gene CNV Profiles	-1.0	-1.5996
diencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
FB-19-ZG81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.642362
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.10911
SLC30A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85873
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216043_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RHOXF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.7856
TD-69-UA90_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.316321
BATF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE102467_3_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_17569_KD_WWTR1_SRP345888	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.70154
regulation of inflammatory response	GO Biological Process Annotations 2025	1.0	null
GSE206516,GSE206518_6_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.354
Perturb_7597_KO_TENT3A/TENT3B_SRP400572	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.1726
liver	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE125862_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_6736_KO_NORAD_SRP066895	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.74627
GE-40-GQ38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.352372
BTBD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47552
Brain Lower Grade Glioma_LGG_TCGA-QH-A65R-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DA-80-IV36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203623
BB-77-QQ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317083
GADD45B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09926
FC-67-SZ42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.366816
ABC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.08217
Internode	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.702
bone marrow	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RE-44-GR79_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228341
CRCGN016_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.45697
MRPS21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93638
KISS1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06481
DD-10-NA60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.29404
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA-68-KG29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264629
Perturb_15178_KD_NR037661_SRP394097	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.19115
GSE129153_0_v_1_forskolin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-A5G8-01B-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ASCL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	95.266
Perturb_14307_KD_SRSF1_SRP230637	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.86696
liver	HPA Tissue Gene Expression Profiles	1.0	1.81244
CD-16-KY17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.274512
GC-04-UF36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.602856
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.5182
SLC12A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77894
Perturb_7629_KD_UPF1_SRP129007	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.03363
PSME2	Pathway Commons Protein-Protein Interactions	1.0	null
DA-35-DU85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234484
GB-16-SU72_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223295
HA-38-ML65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.431185
YB-79-DM48_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.480629
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23232
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PB-13-ZD03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226891
Perturb_3937_KO_DBC1_SRP371865	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.98142
PMC12255818-41467_2025_61448_MOESM1_ESM.pdf-54-ZNF428_ZNF428	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.17918
Perturb_3522_KD_CNOT1_SRP337789	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.9404
XD-44-FJ34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.321139
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4295
GD-79-JJ38_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.411795
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22124
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
6098_PAXBP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.639525
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FBXW2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43616
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AG-06A-31R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE211215_1_v_0_pemetrexed_human	RummaGEO Drug Perturbation Signatures	1.0	null
EE-61-NU30_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.35318
Perturb_11949_KD_NRF2_SRP092641	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PKNOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37037
PHF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03024
NFATC3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8715
NCI-H1666	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15155
Prostate adenocarcinoma_PRAD_TCGA-FC-A6HD-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTDSP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39836
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-0.793526
HCC2218	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.38281
EFL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95468
CRCGN016_MCF10A.WT.HP_24H:A23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10693
TUBB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23973
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.73472
smallintestine_4b	HPA Tissue Sample Gene Expression Profiles	1.0	1.0298
BB-86-BE19_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294469
MCF7_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141561
YA-85-VH07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203955
PHA granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.62
GSE206516,GSE206518_1_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.278346
primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2112
Acute Myeloid Leukemia_LAML_TCGA-AB-2861-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LOUCY	CCLE Cell Line Gene CNV Profiles	1.0	1.48451
hsa-miR-4450	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
WA-15-KX40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.844137
MCF7_PF-3845_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167798
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WO-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW 837	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35321
BE-71-AV63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.446427
BF-44-HD37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.422728
CRCGN017_MCF10A.WT.HP_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12935
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	154.818
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-RY-A83Y-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VK-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6989
EML2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31842
Perturb_13902_KO_AS3MT_SRP332674	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.65901
OTX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6199
REXO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63032
BB-79-AG41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.14524
NCI-H1734	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.878597
OC-23-QX66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.314209
KA-09-PB43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.325935
GSE158834_1_v_5_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CA-17-XB39_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289464
EAPP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61087
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZMAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71306
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.566865
MKN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.26497
HA-81-VN33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.625112
Perturb_11507_KD_ID1_SRP130910	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.46749
USF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
F2R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23759
8424_SRRM1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.67209
9837_WDR70_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.11201
BA-41-VY30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.275202
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VN-A88P-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE151612_0_v_3_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
RANBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65542
ZB-16-BR73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.494527
KC-36-DK23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257845
GC-67-AH43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.374562
8227_SNRPC_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.513979
posteroventral (inferior) parietal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.80213
CTCF_lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Calcipotriol	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.62
MCF7_Clevudine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169584
BF-52-HF07_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210805
HA-99-PM50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214188
Perturb_14598_KD_E2F1/E2F2/E2F3_SRP252426	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.8567
HCC1534	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-3.82124
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.589194
S0-EE-YAXR_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.667454
1408_CDC5L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.566809
DD-44-OX00_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.391855
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A8HY-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
S-phenylmercapturic acid levels in smokers	GWAS Catalog SNP-Phenotype Associations 2025	1.0	10.0
DD-42-DB72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.298058
GSE147876,GSE147877_2_v_9_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FAM171A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01485
GSE213588_10_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.92828
fat_a.V1	HPA Tissue Sample Gene Expression Profiles	1.0	1.23867
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7172
PMC8143797-elife-62857-fig3-data2.xlsx-DEgenes_SW872_TAZ-CAMTA1_vs_EV-Gene_CAMTA1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_2476_KD_PHF8_SRP229951	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.52986
Chela	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.778
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.905429
GB-27-AY54_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.688813
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1506
YF-77-FV50_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24685
S0-EE-YAXR_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.344911
ZNF213	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	101.585
GD-69-KC91_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208138
Perturb_394_KO_FOXM1_SRP272209	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.94556
bone marrow	HPA Tissue Protein Expression Profiles	1.0	1.76435
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.34213
A498	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58717
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
MTARC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78623
TF-04-RX73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.573383
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03611
CCDC59	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69241
Esrrg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.9696
CF-15-FD69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200596
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
10569_ZNF705B_ENST00000443676.1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.58191
GSE120612_4_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GF-53-OL28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.405067
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMEM238	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79507
GSE253089_0_v_1_ephb2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-84-QG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223402
KA-50-OP35_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237881
EA-62-MI89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.54933
female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
FE-75-VG41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.336812
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DH-A669-02A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IB-94-WM88_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.436125
Perturb_14570_KO_RORC_SRP185849	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.79503
ECD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5192
WE-25-AN91_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250733
Tipiracil	DeepCoverMOA Drug Mechanisms of Action	1.0	0.21
Extracellular exosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Perturb_3629_KO_HDAC3_SRP355605	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.27588
CRCGN017_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.094
MAEA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.37026
MSH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.20958
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
Perturb_2278_KO_SLC35F5/SLC29A4/SLC28A3_SRP308916	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.43039
GSE102505_1_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SLC22A23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67142
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NB-89-OV56_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245501
KLHL31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67319
Perturb_7443_KO_METTL21B_SRP096025	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.60693
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RF-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dopachrome isomerase activity	GO Molecular Function Annotations 2025	1.0	null
GSE227592_8_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09108
EOGT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44711
Six4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.0816
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.09879
HEY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.18371
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hsa-miR-193a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.092495
fat_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.02521
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
10751_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.567961
ATRX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.47043
ZNF79	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96694
cytokine receptor binding	GO Molecular Function Annotations 2025	1.0	null
gallbladder_5c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.51157
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06929
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_3874_KD_PLG_SRP333146	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.93969
LC-57-RH78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261238
Perturb_2324_KD_SF3A1_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.92967
AC-79-CQ25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214495
DHX38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31003
SBK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78336
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1058_KO_ALPG_SRP277076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.4343
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24363
GSE158834_2_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A17Y-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE103068_0_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03101
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A6C6-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
S0-EE-Y4UM_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.42981
SLC7A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88862
Perturb_3203_KD_ARRB1_SRP302544	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.03515
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.70182
AC-55-XA97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.27976
MINDY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72028
GSE215155_0_v_1_golph3_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-let-7c	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Perturb_8303_KD_SRFBP1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.2541
BC-43-JW95_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.385597
GSE215086_5_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SUPV3L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24693
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S13-Table_S13_MR_resluts_of_brain_pQTL_and_large-artery_atherosclerotic_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
FOXC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9445
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.55631
FE-49-VJ28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.394082
embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Sarcoma_SARC_TCGA-IS-A3KA-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BB-45-NH69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222652
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222298
TMEM200A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52091
Perturb_12934_KD_DHODH_SRP340404	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.04985
CRCGN016_MCF10A.WT.HP_24H:P11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3795
amygdaloid complex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05959
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300317
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HD-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A6AW-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6463_OE_NFAT1_SRP173011	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
8460_SSU72_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.503538
SB-29-ZH97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24145
Perturb_7626_KD_UPF1_SRP120604	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.03363
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF816	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	85.7749
TUBE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6376
GSE147876,GSE147877_2_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RNF214	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63285
u2197	HPA Cell Line Gene Expression Profiles	-1.0	-0.883624
EF-85-DA07_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208906
GD-17-GR17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.790943
HF-36-FK93_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.495931
5861_NUDC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.605879
GPR180	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44746
Perturb_2761_KD_FOXA1_SRP077334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE106661,GSE106665_2_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
ERF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42486
Sarcoma_SARC_TCGA-K1-A3PN-02A-11R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRUB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.44171
GD-17-GR17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204992
Zic1::Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.5162
GSE211128_2_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_8334_KD_HCF1_SRP178073	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.97674
GSE119978,GSE180930_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
USP44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6528
BF-89-QD24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280846
COV504	CCLE Cell Line Gene CNV Profiles	-1.0	-1.97843
3633_HAT1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.646838
Perturb_9829_KD_USP7_SRP256243	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.1879
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.5822
TCF3	ENCODE Transcription Factor Targets	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A852-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LC-12-VN85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237793
GA-01-EO66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.279691
JB-75-NC66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.310643
Perturb_14156_KO|KD_KBTBD4|RCOR1_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
CB-44-RT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.876401
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.952128
NR3C1	ENCODE Transcription Factor Targets	1.0	null
NA-29-UI75_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221733
CTNNAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45041
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAUZ-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE116930,GSE116935_3_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78M-01A-21R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_1041_Mut_C15orf48_SRP289006	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.29501
GSE168401_1_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
G6PD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87404
KYSE-520	COSMIC Cell Line Gene CNV Profiles	1.0	2.11167
extracellular region part	GO Cellular Component Annotations 2015	1.0	null
BE-73-KD75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.410379
ZNF324	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.8463
CRCGN014_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.34859
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-A492-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
hsa-miR-4667-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
TTPAL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25576
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.43784
Schizophrenia	DisGeNET Gene-Disease Associations	1.0	null
LRF	MotifMap Predicted Transcription Factor Targets	1.0	null
MB-53-WO35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.347184
GB-37-WI36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212271
METTL14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84721
FBL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02571
GF-72-OO48_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.364528
MCF7_GSK J1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155062
BT549	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.798042
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.44137
hsa-miR-1266	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Connecting tubule cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.02
CRCGN008_HEPG2_24H:B14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5066
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00174
BCL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77914
ND-35-VF18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.29396
ZBTB12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9526
TENM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21929
ED-12-PB22_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259385
phenylpyruvate tautomerase activity	GO Molecular Function Annotations 2025	1.0	null
CB-92-FS28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.388909
Petiole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.947
BB-37-LS05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213166
PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
BA-68-FJ41_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.422723
TLN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.48956
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.03206
USF1_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10025_KD_TIAL1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.38114
LB-24-KP05_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.576715
ND-57-WU44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.340016
QB-06-VC83_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.304306
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
(S)-Zopiclone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.2
NOTCH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4746
CXXC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17286
esophagus_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.894724
hsa-miR-3180-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.212286
FB-06-IU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227657
AB-18-YN11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.09979
smoothmuscle_8c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.01079
GABPA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Tie2 kinase inhibitor_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137918
CE-15-YU05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.477008
AA-92-NW83_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216536
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.834899
Arntl	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.2699
Perturb_3595_KO_HRI_SRP218218	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.37164
9837_WDR70_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.504391
LF-64-NB46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.309775
NFYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.092
GSE258991_5_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JF-96-HH81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.327907
RNA polymerase transcription factor SL1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.561
AE-73-KX58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230582
ISOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72265
GSE239844_11_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DA-15-PU65_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290983
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.936231
Perturb_10059_KD_XRN2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.57491
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.21003
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.62844
CRCGN015_MCF10A.TP53.M_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5731
USF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-2861	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
BF-27-HP68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213677
CRCGN016_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.42129
AD-45-YB25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.282748
HF-57-QB74_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206009
A549_Linifanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208892
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.24624
FD-62-ZB67_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.3513
MED20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99742
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CC-01-ER18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242821
Perturb_705_KD_SETDB1_SRP116954	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S12-Table_S12_MR_resluts_of_brain_pQTL_and_any_ischemic_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.51261
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.51914
Perturb_7910_KO_CLP1_SRP367036	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.3488
HB-13-XB94_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.88397
A549_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191427
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_970_OE_SRSF1_SRP174924	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.61723
GSE140997_10_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Rectum adenocarcinoma_READ_TCGA-AG-3725-11A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.705
SERTAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10009
ACOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51638
Prostate adenocarcinoma_PRAD_TCGA-EJ-7318-01B-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05985
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	87.4623
TFE3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0791
GNG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02421
CF-91-JY05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.702231
THRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.4615
Perturb_11357_KD_MAP3K7/CHD1_SRP310158	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.015
lm2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.522
carboxy-lyase activity	GO Molecular Function Annotations 2025	1.0	null
UTP23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11912
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39406
OC-10-FB51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.528942
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
INO80D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8635
chr22_23945830_G_A_b38	GTEx eQTL 2025	1.0	1.4169
Perturb_3886_KD_CTR_SRP124930	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.34464
Chelate leg	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.777
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.999558
SE-81-RI20_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.312872
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-68-OJ16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.542161
HCC38	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.938092
BC3H1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.07
BJAB cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.611
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09189
Lung squamous cell carcinoma_LUSC_TCGA-98-A539-01A-31R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAMKV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47163
SPRR2F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58487
Perturb_95_KI_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.10397
GF-57-LR72_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289012
MCF7_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153869
BF-22-EP86_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236348
IA-48-KI53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246459
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.53389
hsa-miR-3620	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
hsa-miR-3605-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GSE218378_1_v_0_pbx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ABC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07077
MF-04-HB41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.431856
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
SLC35A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.49488
FE-59-BC81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.279124
CRCGN015_MCF10A_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.12995
kidney_b	HPA Tissue Sample Gene Expression Profiles	1.0	0.890946
GSE158834_1_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OE-03-IU44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.253412
GSE211262,GSE211263_3_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JC-96-ID26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25753
RTBDN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41829
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.16391
NMRK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61731
AE-38-LX10_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242885
Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5909
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9884
Lung squamous cell carcinoma_LUSC_TCGA-39-5037-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BD-23-MT28_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218161
1971_CWC15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.551301
MCF7_Prednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151369
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.518285
HF-57-QB74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.45513
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCM3AP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32819
HA-48-LV39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.391634
LHX9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04555
FD-35-PQ00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.376811
TNFRSF18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00128
SELENOK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71166
PC-18-VX23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.326046
CB-12-HC20_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.352404
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.84
ZNF549	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.4357
SKCO1	CCLE Cell Line Gene CNV Profiles	1.0	2.65585
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A85J-01A-12R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.70347
KPL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.9715
CDC34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1746
G401	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
LB-17-PD08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.445708
FD-67-GI76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243112
LD-12-GA99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24045
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T5-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PANC0203	CCLE Cell Line Gene CNV Profiles	1.0	1.5312
GABPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17793
JF-15-IJ23_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200081
SHISA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19031
CRCGN015_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.70913
Perturb_8280_KD_DDX5_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.91168
OA-10-PB21_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.468848
MCF7_Ki8751_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126842
Perturb_12370_OE_SNRPA1_SRP291347	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.60116
BA-95-YU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.698011
SLC29A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49876
TIGD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44893
CRCGN015_MCF10A.TP53.M_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3585
CAL-120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.915745
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YF-77-FV50_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271485
CRCGN009_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30923
HC-83-TS50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239898
KD-31-TU05_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.557351
Adenohypophysis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.955
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-40-KV26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25957
chr22_23912675_G_T_b38	GTEx eQTL 2025	1.0	2.23176
YD-38-CI01_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265739
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.261
IDS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01472
IA-48-KI53_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229492
YY1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4756-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Prostate adenocarcinoma_PRAD_TCGA-V1-A8MF-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZD 7288	DeepCoverMOA Drug Mechanisms of Action	1.0	0.23
CRCGN015_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9336
Lung squamous cell carcinoma_LUSC_TCGA-33-4582-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7186_RBMX2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.647429
Pancreas	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BF-49-QA17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292834
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S11-Table_S11_MR_resluts_of_brain_pQTL_and_any_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
SMIM12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11463
GSE219195_0_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE191021_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	1.0	null
HA-81-VN33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.54409
Rectum adenocarcinoma_READ_TCGA-AF-2693-01A-02R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_2373_KO_ASXL1_SRP305063	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.3754
AD-98-UM13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234171
EC-55-XG31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21475
LE-94-HL75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249992
nasopharynx	HPA Tissue Protein Expression Profiles	-1.0	-0.793526
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-let-7i	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GSE201270,GSE201272_0_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DD-66-VY52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243519
OE-03-IU44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.386349
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39406
AB-41-VZ28_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260181
CAOV3	CCLE Cell Line Gene CNV Profiles	1.0	2.05598
IA-10-ET40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21093
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.606906
AA-87-EI21_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.01163
AA-56-JY17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.466424
hsa-miR-1908	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
6632_PPIL4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.517036
CHRD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.73198
LN-18 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.978
CRCGN015_MCF10A.TP53.M_24H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0788
Endocytic vesicle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.261
Egg chorion	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.944
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
megakaryoblast	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Nr5a1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.5497
BB-57-NT83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223591
DUSP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.31864
DPY30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28789
Lung squamous cell carcinoma_LUSC_TCGA-56-8305-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
S0-EE-YEL3_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219346
marrow cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BD-69-GX17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216409
Perturb_13603_KD_KLF4_SRP221596	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.95158
EC-95-BQ25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.287863
1570_CHERP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.732057
Perturb_8794_KD_AML1ETO_SRP384263	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.99815
Perturb_2557_KD_NXF1_SRP226431	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.24904
3567_GTF2A2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.525693
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE207301,GSE207303_1_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210101,GSE210114_0_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FAAP100	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82428
PMC11233907-mmc9.xlsx-S8-Table_S8_Colocalization_Analysis_for_MR_TWAS_PWAS_Hits_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
KA-29-AB08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.325709
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vagina	GTEx Tissue Gene Expression Profiles	-1.0	-1.0804
Perturb_7798_KD_UPF1_SRP063462	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.44199
Silique	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.005
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3465-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.58449
JE-04-LS32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307124
BA-68-FJ41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.80548
AC-33-YJ09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251099
EA-09-HM95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.697814
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.59585
CRCGN015_MCF10A.TP53.M_24H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13952
GSE158834_11_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-83-ZM06_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226503
AE-19-BK71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.274407
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5174-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LC-78-EV09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265545
GPR150	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60993
CRCGN011_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9001
LN-229	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14701
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.29835
S0-EE-Y79N_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.80928
DUSP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8572
DA-10-VU83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215047
Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M8-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LD-36-DG33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25654
NDUFA9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0627
GSE188721_2_v_4_mesp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_17640_OE_WWTR1_SRP298391	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.86471
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.772235
5441_NACA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.588452
GSE148321,GSE169423_2_v_1_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220509
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.07748
Blood	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
IA-35-KC86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.524069
DC-51-WE27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.749877
8897_THTPA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.564002
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	90.3666
BC-75-CK91_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.44399
KNS42	CCLE Cell Line Gene CNV Profiles	1.0	1.3872
Perturb_12359_KD_SF3A1_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.0231
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.636115
EC-62-NP61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261264
Perturb_8837_KO_RBM12_SRP369839	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.07705
Perturb_9080_KD_FGFRL1_SRP319532	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.5244
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.503952
Uroepithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.616
ZNF365	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67613
KB-37-OO25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.585899
Sarcoma_SARC_TCGA-QQ-A5VB-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CB-13-ZM26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.3514
CD-16-KY17_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204255
Perturb_12541_KD_UGT2B17_SRP166340	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.5668
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058364
EB-44-GM58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210622
CE-24-LQ98_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250828
pancreas	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PSMG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8688
YIPF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82207
adult stem cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.482894
JA-77-UH38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206388
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.874973
NOTO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27484
GSE158834_7_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.565855
GE-25-YQ75_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.295567
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41P-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BA-44-WG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.651933
HC-76-SY22_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305441
DC-99-NQ50_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22963
Doramapimod	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
H3-5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91928
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30901
DC-99-NQ50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.361503
OC-10-FB51_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.77795
positive regulation of response to external stimulus	GO Biological Process Annotations 2025	1.0	null
BC-62-RZ55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.57271
EXOSC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77526
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.6197
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.88422
Cardiomyocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.545
CRCGN017_MCF10A.WT.HP_24H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2354
YE-01-JU83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.362725
CNTROB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01598
IFNAR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13011
SPI1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-94-A5I6-01A-21R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EP-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
endometrium_8a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.98807
INA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.036
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5881-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6D8-01A-31R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PF-59-CY33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.81273
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13864
ING1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61736
CRCGN008_HEPG2_24H:G24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.57375
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.17295
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3782
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RR-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HES3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64922
NMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70284
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2327
TRIM26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29411
NFYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7073
NFIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.7601
FBXL15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88016
DF-95-CY55_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202711
BE-72-EW73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.328606
ZNF140	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86392
FASTKD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.76406
cell part	GO Cellular Component Annotations 2015	1.0	null
ovary	HPA Tissue Protein Expression Profiles	-1.0	-0.793526
extracellular vesicle	GO Cellular Component Annotations 2015	1.0	null
QA-25-HL62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.474707
GSE248874_1_v_0_pcdh9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.176
Lung adenocarcinoma_LUAD_TCGA-49-4506-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216043_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF431	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41224
ZNF682	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.7722
Perturb_3865_KD_ITPR3_SRP333146	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.99303
ONECUT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83115
KE-37-MN32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256727
BC-20-WA90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250582
ZR75B	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.777899
GSE227127_1_v_0_diclofenac_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MRI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55618
NUP93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31976
GSE139016_3_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
AB-09-EA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.907985
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5085-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PNISR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73249
ZB-62-QB90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.483104
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45083
RNF187	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70543
LC-21-LG46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285538
YC-57-OY42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205034
RB-80-RO52_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.508196
GD-51-SU60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.331498
HC-09-KP12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239756
AD-00-WA10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.321598
HT-1376 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.64
AB-66-IL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.340752
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A560-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3682-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
PC-62-AQ92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.490126
SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.2526
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_1_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-85-ME82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219213
DE-85-FR73_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.278296
GSE211425_1_v_0_mettl3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66717
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08118
9587_UMPS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.708463
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
GD-51-SU60_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.395953
GSE116810_2_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
LA-69-OL77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.366851
DE-20-VX20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206495
NCI-H2347	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.24299
CB-99-NG16_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201085
GFPT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44816
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	103.844
amygdaloid complex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.839283
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brockmann body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.428
BA-41-VY30_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.456176
AB-57-IZ37_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258871
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.17918
GSE205976,GSE205978_2_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LF-37-AX51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250138
HCC1143	CCLE Cell Line Gene CNV Profiles	1.0	1.38462
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE140997_2_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
AB-18-YN11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358242
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01863
CRCGN015_MCF10A_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.21605
ERF::NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.1247
ZYG11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57525
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LY-01A-31R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PD-94-WO47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.313351
OSC-20	COSMIC Cell Line Gene CNV Profiles	1.0	2.11167
GSE228106_3_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.877201
Cystic echinococcosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.283
Thoracic leg	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.644
GLRX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24258
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.2382
GSE229973_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GE-01-QX17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.350769
NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.4101
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.13826
A549_Celecoxib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017337
CDK18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.39105
CHEMBL2397099	DeepCoverMOA Drug Mechanisms of Action	1.0	0.89
HD-41-DX72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225224
TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.3359
CRCGN009_HEPG2_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23518
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.450892
NLGN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1096
HD-68-CB31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225878
HF-35-HT37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.340922
APBB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44172
Perturb_10056_KD_SUPV3L1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.48952
FOXD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95978
SKLU1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.79047
extracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE228106_0_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80735
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03053
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236621
JD-87-MR82_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.412789
STYXL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93348
ZA-63-AC60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244672
GSE147876,GSE147877_4_v_9_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PITX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3746
JE-61-XN48_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.645613
CENPV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24541
Lung adenocarcinoma_LUAD_TCGA-69-7979-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LC-96-WR85_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.455952
CHMP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98097
CDKN2AIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49608
QD-13-FQ44_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216663
CA-39-ZJ18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248314
CTCF_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7317_Mut_RNPS1_ERP130711	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.21022
AB-12-IS33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235617
ZIC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	107.844
Perturb_3917_KO_ARID1A_ERP114370	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.79407
CRCGN017_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6035
ED-83-GF49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263424
AF-33-AM86_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.510695
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5352
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	3.23261
Mesothelioma_MESO_TCGA-SH-A7BD-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_2358_KD_RPL7_SRP072302	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.05337
AC-57-ZF49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261685
GSE158834_1_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TBKBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.03405
JE-55-OJ53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.457879
BC-82-PP66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.93357
GSE158458_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF-10A cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.824
BB-79-AG41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.48465
UBE2S	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00151
BHLHE22	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.7576
1918_CSTF3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.609454
PTTG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47744
GSE242290_1_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.873983
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-6D-AA2E-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GNB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93607
Acute Myeloid Leukemia_LAML_TCGA-AB-2984-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NE-34-OZ69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.762415
Perturb_15142_KD_LINC00473_SRP257261	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.78652
BA-77-US35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220615
Lung squamous cell carcinoma_LUSC_TCGA-77-8128-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IC-37-QU39_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23011
Perturb_11562_KD_BAX/BAK_SRP348085	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
PAX5_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252717
LE-81-PG11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.535435
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.40631
XE-69-AT35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247807
anterior (rostral) cingulate (medial prefrontal) cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.951182
GSE233183,GSE233187_2_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.39655
NYAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.54851
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6485
Perturb_11434_KD_SRF_SRP152523	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.03995
BD-39-KG21_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21119
GSE125014_6_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_6706_KD_ELOA_SRP314942	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.2182
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3197
SFT2D3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16723
AD-92-QZ55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20837
BD-69-XG81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204689
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09108
negative regulation of macrophage migration	GO Biological Process Annotations 2025	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5117-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.95386
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.952281
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6HZ-11A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.17102
A549_PHA-680632_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129279
SNU626	CCLE Cell Line Gene CNV Profiles	-1.0	-2.0438
FD-67-GI76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.315235
hsa-miR-1253	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GSE254649_2_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TC-36-AL79_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238323
FA-16-HR75_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.417555
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.28435
endocrine pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.486716
placenta	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HE-80-BQ08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244917
CB-99-OG76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.850974
GSE205163,GSE205164_2_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:F11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06725
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	102.134
PPP1R3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76875
RA-49-ZB08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.287416
AC-30-XU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.599691
Perturb_7247_KO_CTNNB1_ERP109990	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.05514
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUM-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202434,GSE202438_9_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.57299
E2F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5173
IE-36-BO23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227271
Perturb_11383_KD_SRF_SRP152523	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.71831
INO80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02775
Perturb_9832_OE_UGT2B17_SRP166340	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.36504
RD-57-WQ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217559
RUNX2	JASPAR Predicted Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2720-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
liver_c	HPA Tissue Sample Gene Expression Profiles	1.0	2.81586
Perturb_6871_KD_HHEX_SRP323378	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.35091
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF805	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05047
Perturb_2148_OE_RKIP_SRP189735	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.59525
Perturb_2316_KD_PRPF31_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.4551
GSE140997_2_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
TE-26-XS06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.295383
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MRPL47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5837
7156_RBM14-RBM4_P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.27764
GSE210101,GSE210114_5_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1569	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.958537
CRCGN015_MCF10A.TP53.M_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24854
ACSM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34649
CE-35-LA42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.846101
AA-57-FZ47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.698251
IB-87-ZR37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242358
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
INPP5K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01888
Perilymphatic space	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.831
STAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16191
Perturb_9926_KD_SRSF1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.80649
E2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2841
Liver enzyme levels (gamma-glutamyl transferase)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.869897
EMC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.6493
Perturb_348_KO_KDM2B_SRP250460	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.90996
Extracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Guard cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.001
A549_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140966
MX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10214
XC-61-SE50_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.884324
Perturb_6755_KO_UPF3A/UPF3B_SRP327782	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.40441
OIP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.17955
posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1038
IVNS1ABP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80791
GRINA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.37062
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.544927
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CE-20-VA70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.408457
Perturb_12232_KD_SNRPA1_SRP291357	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.11358
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244965
JHH7	CCLE Cell Line Gene CNV Profiles	1.0	1.43135
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.952281
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5892-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE195559_2_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ODF2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15979
KIAA1671	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73023
DA-62-QB27_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.304705
AC-58-RM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.339304
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.5708
POU2F2_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88854
DF-56-GR45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.4971
A549_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173951
GSE200839,GSE233826_5_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
1918_CSTF3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.835405
DD-42-PC65_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200376
Lung adenocarcinoma_LUAD_TCGA-50-5044-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11953091-12035_2025_4695_MOESM1_ESM.xlsx-s5-Supplementary_Table_5_Results_of_the_2-sample_pQTL_MR_on_insomnia_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	55.9274
CRCGN016_MCF10A.TP53.M_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06586
BHT	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
Lung adenocarcinoma_LUAD_TCGA-73-7499-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-5819-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Neuroma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.015
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.579735
AD-28-GJ71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.433532
BB-37-LS05_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.612981
Lung adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.065
CLEC2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81824
Perturb_7241_KD_UPF1LL_SRP295982	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.17306
Perturb_13873_KD_ELF4_SRP182698	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.29704
hsa-miR-4287	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
IC-05-WD74_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24675
S0-EE-YEL3_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201217
MCF7_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015304
HE-34-ZC14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.402366
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8586
Perturb_10015_KD_HNRNPC_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.2848
DA-17-YW85_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.394896
DC-43-KF54_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234337
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZNF708	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.755
KB-65-GP42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.413898
IB-87-ZR37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270764
BA-59-EN38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.43269
ND-57-WU44_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212119
IRF4	ENCODE Transcription Factor Targets	1.0	null
Perturb_3936_KD_MIR1290_SRP291996	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.84986
PBK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22751
Diabetes Mellitus, Type 2	HuGE Navigator Gene-Phenotype Associations	1.0	null
chr22_23945454_A_G_b38	GTEx eQTL 2025	1.0	2.56811
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.733404
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.625
H4K5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_13021_KO_ALOX5_SRP367905	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.72006
AA-68-OJ16_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.589194
OE-78-TD20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.541
MCF7_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184481
ALG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52304
AD-18-XC14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.768317
BB-43-YQ76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.435106
DF-45-GA42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22962
PAX5	ENCODE Transcription Factor Targets	1.0	null
TAF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80409
Perturb_8807_KD_PAI1_SRP372261	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.35605
Lung adenocarcinoma_LUAD_TCGA-55-8514-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_LNCaP clone FGC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NE-20-WM78_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228435
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06821
Perturb_9669_KO_NR1H4_SRP115904	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.2059
CE-35-LA42_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.87494
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.739651
ZNF710	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7631
BB-40-DA70_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236008
TTLL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.58425
chr22_23924680_G_A_b38	GTEx eQTL 2025	1.0	6.55167
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.833955
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
ventrolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.973099
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-94-7033-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CC-90-EX35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241911
ED-92-AL11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246798
HB-29-DM15_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211386
CB-02-XL81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260485
Perturb_7148_KD_HBS1L_SRP070129	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.31841
AA-10-VR76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202909
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4797-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A3-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BC-07-FZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262857
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CC-46-CE74_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232741
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8571
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CB-82-PL01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.312922
YAPC	CCLE Cell Line Gene CNV Profiles	-1.0	-1.77811
OLFM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55714
DB-33-HZ87_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.545779
LY 487379	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.76
GLIPR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.69777
Root apex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.557
TMEM256	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62057
BB-42-FF52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201731
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-5428-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GA-56-IU17_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.335161
PMC12178829-mmc4.xlsx-Sheet_4-MEG3-KD_Up-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EC-98-YS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.657557
CRCGN008_HEPG2_24H:C12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4096
PMC9305137-PATH-256-297-s005.xlsx-CIC_associated_DE_genes_IDH1-W-Unnamed_1_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
testis	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44198
Tubulin inhibitor 6_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0169554
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Connecting tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.55
TIPIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45584
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45Q-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOSL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHAGOK1	CCLE Cell Line Gene CNV Profiles	1.0	1.3804
NR1I2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.7549
MCF7_Azacitidine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160211
YPEL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95307
PC3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33034
EGR1	ENCODE Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7218-01B-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KYM1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.59447
1842_CPSF3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.546023
GA-77-MH38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245998
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
AB-74-VK99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.316295
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09108
GB-27-AY54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.330362
CA-75-HA22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236669
7524_RPS3_P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.503736
HCC1143	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.78676
Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JMJD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20298
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8451
CRCGN017_MCF10A.WT.HP_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5863
HADHA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67398
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.53913
GOSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9554
FOXP2_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275189
2376_DROSHA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.508279
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1
GSE121824,GSE121826_0_v_2_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CL-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.840345
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1984
CRCGN015_MCF10A_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.69944
MEIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5107
gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
hESC_Derived_CD184+_Endoderm_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.999697
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.301273
IPPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22585
E2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7924
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.937236
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282291
BD-39-KG21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220168
GSE158834_11_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WB-82-EL69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302251
HUG1N	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34742
GA-68-KC29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230034
XD-44-FJ34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.338741
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S15-Table_S15_MR_resluts_of_brain_pQTL_and_small-vessel_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
HT29	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37848
A549_Celecoxib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146226
DE-65-KO26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233995
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Lung squamous cell carcinoma_LUSC_TCGA-77-6845-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14375_KD_IGF2BP1_SRP291710	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.31361
NFKB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.1503
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237064
BD-45-EU45_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201204
Perturb_3142_OE_CXADR_SRP274008	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.79527
MCF7_Epothilone A_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129148
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CB-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ModE complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.618
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
HS 852.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.947571
AB-63-OW35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.636507
LDB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.48323
NPEPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50886
ND-20-AS37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213862
ID-30-ST90_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245817
DA-17-YW85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.317692
membrane-bounded vesicle	GO Cellular Component Annotations 2015	1.0	null
SNAI2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1384
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_1_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EE-49-CD29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239741
CE-38-KX20_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206704
CEP350	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95702
TMEM11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61246
RELB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.966
CRCGN015_MCF10A_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8631
Diencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HEC265	CCLE Cell Line Gene CNV Profiles	1.0	1.39687
lyase activity	GO Molecular Function Annotations 2015	1.0	null
Perturb_11971_KO_SUZ12_SRP327198	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.28696
DDX55	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.04935
DB-84-EQ63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.432635
EKVX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.19582
Perturb_8428_KD_METTL3/METTL14_SRP274360	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.77119
STAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16331
UA-91-HL97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228149
OE-78-TD20_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.516703
DC-47-KV62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244271
BE-37-IC77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258456
CDKN1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09187
Perturb_3605_KO_ARID1B_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.06517
Perturb_12176_Mut|KO_PLK4_ERP132994	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_702_KD_SETDB1_SRP116954	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.42441
BF-22-EP86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.604127
NUP205	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59674
HNF4G	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9127
blood	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BB-93-VT73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.541615
EA-73-WI86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251337
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051491
hsa-miR-4534	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
REL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.1176
UF-06-JB00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.443197
EBNA1BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64546
KA-63-FH23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.323953
Perturb_15506_KD_MED1_SRP179971	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
positive regulation of inflammatory response	GO Biological Process Annotations 2025	1.0	null
SPHK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77761
OVOL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26763
AB-70-GR31_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.402286
Perturb_8867_KD_PNN_SRP063860	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.5111
Perturb_14589_KI_LAMC2_ERP136718	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.12789
CRCGN015_MCF10A_48H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.29507
H4C12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36844
Leiomyosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.129
AC-83-LN99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.252536
RORB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4773
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_7355_KO_NSUN6_SRP233222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.19942
SOX2-21211035-LN229-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BC-81-LO06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235655
FOXP2	ENCODE Transcription Factor Targets	1.0	null
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28157
DD-10-NA60_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246731
CDK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52673
CRCGN013_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08125
CRCGN015_HEPG2_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.75743
CD-08-MF16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25465
hsa-miR-708	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
Perturb_8136_KD_G3BP2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.55209
AB-63-OW35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.842571
Perturb_7375_KD_PUF60_ERP105778	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.7365
ANKRD35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48034
KA-71-CQ35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.435177
Perturb_14615_KO_MTAP_SRP186070	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.5958
DD-89-HG56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.447435
dorsolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.988427
DE-05-NX87_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221643
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.6364
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.6268
inferolateral temporal cortex (area TEv, area 20)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.927378
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.779465
GSE115395_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PPP2CA	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPDL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11452
HROB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46146
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.34118
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.353363
NOL4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51257
Perturb_2548_KO_MLL3_SRP163132	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.59295
S0-EE-Y79N_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.975553
VC-30-QH05_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.253639
Perturb_7339_KO_TIP60_SRP386875	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.71924
FUOM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.36677
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.91415
AD-30-SU93_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292102
KB-37-OO25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.392282
PLEKHG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45616
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11B-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CGN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36184
RAB23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33256
JF-39-BZ76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.255384
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	1.0	5.87149
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IF-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SREBF1	JASPAR Predicted Transcription Factor Targets	1.0	null
MEOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80627
4951_MED28_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.13744
Mesophyll cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.743
GSE201309_4_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Eplerenone_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0115578
hsa-miR-525-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.893366
Perturb_8258_KD_RCC2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.88455
SD-69-QA40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262311
SUM185PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.936802
TBX20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17671
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BE-28-QT65_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214815
BCR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3046
496100426_PCx_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.19446
ZBTB7C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.419
Head and Neck squamous cell carcinoma_HNSC_TCGA-UP-A6WW-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intramolecular oxidoreductase activity, transposing C=C bonds	GO Molecular Function Annotations 2025	1.0	null
COV644	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.31441
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
BD-33-HT38_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.398176
FD-19-TD14_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289523
Elf5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.4318
RIOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14175
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9495
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.801873
ED-02-CL76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216447
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RP-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KC-21-PG56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.303336
MD-86-UW46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.723613
QF-00-NO42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.459782
BD-23-MT28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285905
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.325
PMC9376070-41419_2022_5157_MOESM18_ESM.xlsx-Sheet1-Table_S4_Differentially_expressed_genes_of_HNRNPC-KD_and_NC_cells_identified_in_the_RNA-seq_analysis_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IL-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE95077_5_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.64769
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.873678
FAAH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20576
GSE138938_1_v_4_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051653
ZFP36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72907
BA-31-KY85_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209376
C17orf58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39327
BE-81-QL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.749042
TSPOAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41781
hsa-miR-28-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.436802
Perturb_9822_KD_RUNX1_SRP103740	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
TERT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11064
lymph node	HPA Tissue Protein Expression Profiles	-1.0	-0.793526
Perturb_3590_KO_USP14_ERP024004	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.15314
col7	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.989
hek293	HPA Cell Line Gene Expression Profiles	1.0	2.65287
CRCGN015_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0362
GSE218949_0_v_1_cep20_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GA-28-SS67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.361278
KMS-26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03231
MCF7_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130376
8772_TCERG1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.506482
chr22_23924860_C_T_b38	GTEx eQTL 2025	1.0	1.06666
Perturb_7323_KO_DCP2_SRP070463	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.62584
FD-62-ZB67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.847933
Perturb_7306_KD_IER3_SRP348787	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.18265
HMG20B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91977
FB-91-BU05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.353676
Proneural glioma stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.367
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.940369
FB-19-ZG81_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226151
KB-17-DU74_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.295419
STMN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91713
CA-00-AR16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.750077
Perturb_6767_Mut_KDM6A_SRP343264	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.42398
JA-42-NH96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227614
Perturb_2981_KD_ISG_SRP158414	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.24703
BD-49-MD69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.383048
GSE224599_0_v_1_tfcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-60-KU38_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212928
IFT140	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60121
EE-98-PF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.400424
Perturb_12149_KO|OE_TP53|CENPA_ERP125655	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.21231
RB-18-SX73_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222662
DA-62-QB27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268737
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.976455
megakaryocyte	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hsa-miR-4266	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
JA-23-QE71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.593262
BF-44-HD37_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24089
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.893366
ID-12-NA84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207144
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HE-99-KP87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301526
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_11382_KD_NKX25_SRP152523	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.23949
MRPL23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18341
NB-89-OV56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205012
KD-00-UJ81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.33693
Perturb_6721_KD_EHMT2_SRP043290	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.34884
ERICH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91864
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7627_KD_HNRNPL_SRP129007	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.79989
SP1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BA-24-BX40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203704
GSE95077_1_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TGOLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.63962
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.5468
Prostate adenocarcinoma_PRAD_TCGA-2A-A8VX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_JNJ-26854165_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117038
DA-07-LL18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.02798
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.423285
KA-50-OP35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.390263
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.952281
Perturb_14374_KD_SRF_SRP150935	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.79085
WSB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0199
HAUS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77891
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
Neurilemmoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
OVCAR-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.947574
ear	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.7335
GPM6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32434
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.4285
Perturb_2801_KD_RBM39_SRP245602	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.6866
SC-17-WW78_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.348473
CA46	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.84578
C2CD4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27302
MTHFD1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69258
H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_12330_KO_ANLN_SRP198272	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.78027
CB-55-GX92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.277115
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22857
ficolin-1-rich granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.737
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.627369
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.09245
GSE178340_7_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8530322-pone.0258316.s002.xlsx-GG_778_no-AA_778_no-Symbol_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
MYC_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AD-41-WB70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219746
VF-20-LY76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20955
bone marrow cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
OE-03-IU44_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.423767
AF-67-LZ82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.833054
CTCF_MCF-7_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051654
hsa-miR-4254	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
PPM1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21869
AB-21-VE32_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.475773
CHFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35015
RPP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44798
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
LF-94-HB11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28537
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.674863
AB-09-AD74_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202807
USF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE102505_6_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DCAKD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12397
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.367715
GSE102505_1_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DLGAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16319
Dowling-Degos Disease	DisGeNET Gene-Disease Associations	1.0	null
GSE158834_7_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CD-41-RE87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262011
PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST12-Unnamed_8_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YO-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
positive regulation of tumor necrosis factor superfamily cytokine production	GO Biological Process Annotations 2025	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
CF-22-OS28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264546
CRCGN012_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47402
QF-00-NO42_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288229
DD-43-WW40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240306
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-CCRF-CEM_EV_vs_ectopic_TET2_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03396
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5EP-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CE-69-FD64_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.418747
IA-65-QX27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.600018
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209727
FF-86-NH56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252221
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.76151
CB-59-ZX97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.29063
Macrophage migration inhibitory factor	InterPro Predicted Protein Domain Annotations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV0-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7496_KD_EFTUD2_SRP192094	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.849
CB-88-LG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224074
TAF1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3456
GSE140997_4_v_5_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.330652
AB-09-NX37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.411551
CRCGN010_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21885
Intrinsic component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.965
cervix, uterine	HPA Tissue Protein Expression Profiles	-1.0	-0.793526
CDK11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72158
GD-90-RA90_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249437
KA-62-FE69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.401746
NCIH146	CCLE Cell Line Gene CNV Profiles	-1.0	-1.78015
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9407_KD_GATA6AS_SRP279802	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.81433
PPCS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23712
CRCGN017_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06144
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.3057
Wt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	81.5758
TENT4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35036
LF-50-IZ49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25672
9475_U2SURP_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.529592
DA-67-HS65_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201498
PC-87-OG75_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.34267
AA-86-YV75_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.354459
MAZ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	91.626
ZBTB40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28773
TNK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40115
LF-27-NX16_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218132
MB-53-WO35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257617
BE-79-QU25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.581321
HC-18-NB46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249958
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.712469
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.805761
CF-32-LB77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.543025
GSE246660_1_v_0_glycerol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23027
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EE-49-CD29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232362
PYM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00532
FD-59-TC81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.942623
Ascites tumor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.72
Evacetrapib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.23
OVCAR433	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.893366
GA-16-IU17_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.305673
SD-51-LL22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257282
DA-86-GO43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.255399
SK-CO-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.11167
BC-20-WA90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.4555
CC-68-YZ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23025
KLHL15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22185
hsa-miR-4740-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Perturb_7662_KD_CTCF_SRP072272	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.12754
POLR1H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22536
hsa-miR-1272	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5939
ACY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30133
FEZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	78.6264
HCC1954	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.07729
DC-23-UM36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.622082
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
RLIM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99518
Perturb_16811_OE_HNF1A/FOXA3/PROX1_SRP167105	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.3103
Right atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.683
XD-18-IF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228597
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	92.4441
GSE158834_1_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169334,GSE169336_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169605
hematopoietic cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.766
BB-48-VW67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209197
Perturb_2332_KD_SNRPE_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.95747
GABPA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
Perturb_3604_KO_ARID1A_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.47123
AC-33-YJ09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.379499
TF-43-DT71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.500424
Perturb_9084_KO_NSUN2_SRP400807	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.8989
AD-99-SN88_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.306375
AC-05-MR83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.749621
TAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60098
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6481_KD_SERBP1_ERP118886	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.3858
AD-89-ID99_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.326385
Intracellular anatomical structure	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
NHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.5135
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KA-63-FH23_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246469
ETFDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18966
RHOXF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90131
NC-27-AD53_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.256057
TCF12	ENCODE Transcription Factor Targets	1.0	null
DLG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71069
GSE205163,GSE205164_2_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
HOXA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39583
OE-78-TD20_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241331
MEIS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.77985
Mono-Mac-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.612
CB-84-FA85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204602
RDH14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15437
GSE195568_2_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.594547
HOXB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68515
FABP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13202
FAM104B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55469
hsa-miR-4763-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GSE181003_3_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8061-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
QC-12-DW06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.668629
FB-91-BU05_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237314
G112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.934436
EKVX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.01941
Skin Cutaneous Melanoma_SKCM_TCGA-QB-A6FS-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE195568_6_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_2_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
hsa-miR-647	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
hsa-let-7f	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
PARD6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76956
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_MCF10A_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.8719
HNRNPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54526
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7722
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4074-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC3153	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.864583
SP1	ENCODE Transcription Factor Targets	1.0	null
Stipule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.896
ZNF174	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39453
KLF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	80.5741
EPB41L4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97741
MD-49-BL92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228672
NR3C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.1684
TEAD4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LOX-IMVI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15155
AE-64-IK64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210845
DFFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7804
KYSE-520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.6951
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.16815
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.9347
GUK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.65334
XB-53-OZ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.454949
CC-15-MK46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.340708
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6113
DE-98-FC24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216159
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.68356
MC-51-BT07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217038
CRCGN008_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15635
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.757759
GPATCH4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62544
CRCGN016_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.83743
Perturb_5735_KD_NAP1L3_SRP121475	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.20953
SB-92-FF15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.391512
EC-82-LV30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.380806
CRCGN015_MCF10A_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.12185
TAF1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE80098,GSE80366_0_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.53916
Perturb_6756_KO|KD_UPF3A/UPF3B|UPF1_SRP327782	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.0622
ZNF283	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91539
STAT1::STAT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.6065
LD-47-RN92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.326424
extracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.057922
AC-17-PC87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246562
FE-37-OL13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.362845
FOXA1_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU2AF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58873
CRCGN015_MCF10A.WT.HP_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.32825
VCY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58646
ND-27-UQ99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.255645
tretinoin_homo sapiens_gpl6244_gds4180	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
METTL23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93219
NB-17-SQ59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261458
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.40317
liver_a	HPA Tissue Sample Gene Expression Profiles	1.0	0.958672
Perturb_7458_KO_DHX36_SRP120505	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.14522
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.69515
Perturb_5447_KD_MED1_SRP395995	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.02937
FD-35-PQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.312772
LE-83-PR92_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257542
hapt1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.562
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.642038
SMAD5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.2084
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.3527
Perturb_7424_KD_CPSF2_SRP045481	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-19.3979
GSE181461_1_v_4_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y8-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_x_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
SCC15	CCLE Cell Line Gene CNV Profiles	-1.0	-1.78031
Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81174
FD-59-TC81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.492045
Node	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.677
CTCF_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8409-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IF-92-OK68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.276374
ASPSCR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92256
LIMS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77262
FA-02-RV60_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257998
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.581098
Lung adenocarcinoma_LUAD_TCGA-91-8496-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CF-22-OS28_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.421949
S0-EE-WH3B_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244771
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
THG1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.6565
K562_Tofacitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015855
Prostate adenocarcinoma_PRAD_TCGA-EJ-7325-01B-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.251
hsa-miR-4500	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
REST	ENCODE Transcription Factor Targets	1.0	null
MKN7	CCLE Cell Line Gene CNV Profiles	1.0	1.87456
Perturb_691_KD_PTPN6_SRP275597	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.0915
CTCF	ENCODE Transcription Factor Targets	1.0	null
TBC1D2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50245
DD-44-OX00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217384
Perturb_7307_KD_IER3_SRP348787	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
CD-75-QY45_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.432642
TCF12_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67K-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A8YI-01A-21R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TE1	CCLE Cell Line Gene CNV Profiles	1.0	2.01311
Perturb_4383_KO_PRMT5_SRP149386	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.44477
ZNF707	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.2662
GSK3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48169
CRCGN008_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.397
2120_DDX41_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.623044
CRCGN017_MCF10A.WT.HP_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.39375
hsa-miR-4712-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
POU2F2	ENCODE Transcription Factor Targets	1.0	null
A549_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141358
LMNA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52991
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-7351-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
G-401	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.15836
GSE158834_10_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BA-84-WN26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249353
Perturb_11348_KD_NFAT1_SRP173011	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
LE-94-HL75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299359
Extracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J2-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.00578
SB-94-ZA83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.13275
Interchromatin granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.84
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10857
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.68642
BA-84-TD72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.467531
Perturb_15998_KD_LUCAT1_SRP221619	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.61863
KA-75-LP02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.378127
Perturb_4761_KO_DLG2_SRP315088	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Eccrine sweat gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.536
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.586293
BB-69-WN73_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.542096
NDUFS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27036
Perturb_14117_KD_RPS6KB1_SRP187713	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.26442
GSE119978,GSE180930_6_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_5_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239844_8_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.70221
624 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.56634
8424_SRRM1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.0656
NHEJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5328
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03053
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206786
Perturb_13942_KD_CDK12_SRP168173	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.40042
CCDC50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35793
Small_Intestine	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	2.01032
CHST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21182
extracellular region part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GA-28-SS67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.80768
OC-15-PM40_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.31043
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2603
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.496
PF-59-CY33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.398013
HCC2185	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.15769
DA-27-BW40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.279168
Sarcoma_SARC_TCGA-QQ-A8VF-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IA-38-XE73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.381508
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.57905
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H7-06A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
1536_CFL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.506353
VF-12-MF80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267942
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BE-66-GV20_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289371
CRCGN011_HEPG2_24H:F18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14855
primary auditory cortex (core)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.37807
Perturb_3534_KD_KIF2C_SRP339333	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.0841
GSE227698_2_v_1_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
C3H10T1/2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.626
MTF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.0305
CE-37-MS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240353
CTCF_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
thyroid_5d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.00698
YB-54-ET23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.747899
CRCGN008_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0726
GSE215086_8_v_6_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
OC-10-FB51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22154
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RJ-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE145249_0_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.28441
JA-23-QE71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.695492
GSE249098_1_v_0_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4135-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DE-58-OW37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.35534
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-52-7810-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DA-01A-31R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF143_02_59	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59753
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.593401
HEL-92.1.7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.789
BC-52-NW28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251833
BA-86-AL61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.310141
FA-12-QB17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292638
GSE202434,GSE202438_10_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hESC_Derived_CD56+_Ectoderm_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.866258
CRCGN010_HEPG2_24H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00237
MYOG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.6633
NDST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05848
DF-57-BL63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259234
ZNF530	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	80.6059
AE-85-KE62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201303
SAC3D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55826
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.69528
CRACR2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02303
XC-81-LR46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.30327
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.833473
105KC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.18669
FE-37-OL13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.816202
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225409
SEMA3G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54402
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BC-94-GN01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.332308
TM9SF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85477
CRCGN015_MCF10A_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.65914
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A3IE-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BB-20-UU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.888747
Siponimod	DeepCoverMOA Drug Mechanisms of Action	1.0	0.49
AD-66-NO48_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238183
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.43552
hsa-miR-548l	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Ozagrel	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.71
HC-83-TS50_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231754
NDUFAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70412
SD-69-QA40_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.298857
PTPRU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63001
RFX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8621
MD-09-FE75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.48556
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5882-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HS-683 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.908
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.86491
Echinococcosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
SB-94-ZA83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.424588
8431_SRSF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.784883
A549_XAV-939_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171775
methylcrotonoyl-CoA carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.621
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LF-45-MW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244995
smoothmuscle_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.83574
CC-09-YG11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231214
Perturb_8446_OE_PCK1_SRP155565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.44567
BE-66-UB12_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237524
ZNF75D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2013
CCDC85C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25649
AA-31-YE07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208757
KATOIII	CCLE Cell Line Gene CNV Profiles	1.0	1.47634
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.38576
NUP50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85684
hsa-miR-331-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
TBX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1708
CRCGN011_HEPG2_24H:E18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0071
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16127
GSE135312_1_v_2_bmpr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9625
cerebellum	HPA Tissue Protein Expression Profiles	-1.0	-0.793526
SIX5_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73G-01A-22R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HACD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78026
FE-59-BC81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.278978
GSE213588_10_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HC-01-FD24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.727427
COLO 849	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.93237
NF-21-HQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.80979
kidney	GTEx Tissue Gene Expression Profiles	1.0	0.833548
CE-77-JB44_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214844
SW 1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45083
S0-EE-Y7IR_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.631113
Perturb_2335_KD_SON_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.5025
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.0606
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EA-07-RB34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.473134
TNIK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15701
Liver hepatocellular carcinoma_LIHC_TCGA-ES-A2HS-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4678	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
HCC1395	CCLE Cell Line Gene CNV Profiles	1.0	1.4955
CC-03-PW00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.56605
Perturb_1094_KO_ATXN1L_SRP230198	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.48287
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.23627
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5UL-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.083336
KA-51-CQ55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.334849
BE-25-UR78_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302524
PB-05-XP37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.415798
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	163.411
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
orbital frontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.28242
CUTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00712
NOP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81597
GD-17-GR17_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210884
PERP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20447
JB-09-SI50_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227979
hsa-miR-4502	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
AD-72-OW33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.402203
LC-57-RH78_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211984
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2582
NB-17-SQ59_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.61617
RPUSD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34398
primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.973099
GSE147876,GSE147877_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_2763_KD_CBX3_SRP077334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.01073
KB-77-BA46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.304172
HC-16-VX59_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211011
Kidney	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Root cap	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.668
NCI-H2596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.91467
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A816-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.01789
GSE219195_1_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_94_KD_B4GALNT1_SRP127547	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.4852
SGPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83261
NFIX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.1297
Sarcoma_SARC_TCGA-QC-A7B5-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_2473_KD_H2AZ1_SRP214665	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.94666
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057584
TOMM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53068
GSE210373_0_v_1_cntnap4_human	RummaGEO Gene Perturbation Signatures	1.0	null
RD-57-WQ44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.40592
positive regulation of ERK1 and ERK2 cascade	GO Biological Process Annotations 2025	1.0	null
EBF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0778
BC-54-ON71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.438556
ADPRM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5279
GD-51-SU60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.822702
SMAD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.1663
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.92401
CB-12-HC20_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226669
DDX24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.06194
cerebellar cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.01002
XRN2-22483619-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
EARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00867
Left atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.415
WDR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11012
GSE206729_3_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF557	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.56706
hsa-let-7b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
TRDMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36396
NB-12-ZK38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252477
MXRA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75597
Liver hepatocellular carcinoma_LIHC_TCGA-HP-A5N0-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04857
WA-00-QY36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.586262
FE-76-CA29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231451
hsa-miR-4512	TargetScan Predicted Conserved microRNA Targets	1.0	0.404082
Perturb_7801_KD_PAF1_SRP064356	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.48314
Perturb_13953_OE_lncNR2F1_SRP179994	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.43238
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A857-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WA-15-KX40_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.37674
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LC-96-WR85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.63051
SSR128129E	DeepCoverMOA Drug Mechanisms of Action	1.0	0.35
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
UE-50-KK32_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25172
Pyrenoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.503
Perturb_9836_KD_GCN2_SRP248465	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.21725
PCED1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70995
PANC0213	CCLE Cell Line Gene CNV Profiles	-1.0	-2.31918
GSE158834_10_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PF-72-IT39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265003
SIN3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
kidney_d	HPA Tissue Sample Gene Expression Profiles	1.0	0.913876
JJ012	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10688
JE-72-KV75_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206233
AB-98-HT45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203143
JB-48-AO57_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.389404
TMEM70	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.678
CC-03-PW00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.43397
Ileum smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.052
FOXP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69504
DA-15-PU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.336303
7424_RPAP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.587179
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.39386
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PPP1R8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23604
smooth muscle	HPA Tissue Protein Expression Profiles	-1.0	-0.793526
PBX3	ENCODE Transcription Factor Targets	1.0	null
UA-91-HL97_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202186
BA-44-WG29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.470726
CRCGN017_MCF10A.WT.HP_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.18015
JUND_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OE-84-HO42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274841
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.791585
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5432-01A-02R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE121824,GSE121826_0_v_6_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.135
ED-27-OE11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.474066
HC-89-WQ85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240609
H2BC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19636
Perturb_2078_OE_PUM2_SRP072710	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.22352
CF-81-DS26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213906
6748_PRIM2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.51824
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.6522
SP140	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.35356
GSE158834_0_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF560	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.01167
Perturb_16793_KD_SPIN1_SRP171066	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.46564
GA-77-FY14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.42903
SREBF2	JASPAR Predicted Transcription Factor Targets	1.0	null
WBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35975
LE-41-QT17_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.449128
d36	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.665
BD-33-HT38_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.499922
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CC-47-VS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.419959
DE-58-OW37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.329154
CENPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09777
fat_8a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12439
KD-00-UJ81_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229481
VPS37C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42515
REXO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.087
Perturb_8098_KD_TUFM_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.2479
624 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27409
C12orf57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55534
BE-05-KR03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235525
HA-32-YH61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.605762
AC-58-RM63_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264515
CTPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2992
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
placenta	HPA Tissue Protein Expression Profiles	-1.0	-0.793526
AB-61-VZ28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211011
SNAPIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38096
LDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11743
CTCF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8530322-pone.0258316.s002.xlsx-GG_778_TH17-AA_778_TH17-Symbol_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_3855_KD_CCL5_SRP333146	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.01484
PMC12571111-qiaf131_supplementary_data.xlsx-ST2-Supplementary_Table_2_Results_of_the_two-sample_MR_analysis_on_the_causal_role_of_CD4_T_cell_expression_profiles_on_CRC_development_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
HSD3B7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27286
CB-12-BV05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.332272
Prostate adenocarcinoma_PRAD_TCGA-KK-A8ID-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CSDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57874
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MD-03-NA01_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209573
RCE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.47132
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.61075
posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.88263
FE-37-OL13_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.448006
skmel30	HPA Cell Line Gene Expression Profiles	1.0	1.00295
GSE182680,GSE182683_5_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30725
RASA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47658
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.956502
GB-84-KP45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.324861
TSEN34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.31807
Perturb_7457_KO_DHX36_SRP120502	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.83736
BD-96-HO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.423598
Lung squamous cell carcinoma_LUSC_TCGA-56-8629-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE227592_2_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-Unnamed_4_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TFAP4::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9775
GSE149035_3_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.8802
INPP5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.31147
GSE186471_1_v_0_carnosol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_1_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXA1	ENCODE Transcription Factor Targets	1.0	null
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.17858
JB-14-ZM03_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204668
Perturb_3720_KD_CHD4/DNMT1_SRP049370	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.05672
HSPA14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92467
GSE158834_7_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EFNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29699
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.42635
FD-62-ZB67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.581082
6625_PPIE_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.751876
NCIH2196	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42726
GSE218060_5_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214252
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I0-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NC-76-YX69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24685
Perturb_8755_KD_SON_SRP300475	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ZC-47-HL31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.761329
MCF7_Thiotepa_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157492
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7161_RBM17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.665418
anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.833692
STAT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9724
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.427591
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A5RJ-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15857_KD_KDM3A_SRP248023	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.58347
CE-15-YU05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.875519
DD-44-OX00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261563
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.66516
AIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06675
ZNF532	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.68862
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.859
AD-45-YB25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.405468
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CALHM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.44369
TAF1	ENCODE Transcription Factor Targets	1.0	null
Perturb_2307_KD_DDX3X_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.79314
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.5702
DQX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19886
Mis6-Sim4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.854
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.805192
KC-45-DZ26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230271
10478_ZNF585A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.07598
HD-41-DX72_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.26863
KATNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04548
organelle	GO Cellular Component Annotations 2015	1.0	null
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1183
STC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54158
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.99221
JE-61-XN48_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.747263
HB-79-CT92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230826
OC-15-PM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280263
TB-55-WY28_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217533
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.936231
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	313.846
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
DDX31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36069
Sarcoma_SARC_TCGA-DX-AB2X-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PE-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JG-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0455
HF-36-FK93_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.676292
CRCGN011_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9828
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00141
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.82482
A549_GSK J1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149903
GABPA	ENCODE Transcription Factor Targets	1.0	null
hematopoietic stem cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
8214_SNIP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.0264
KC-67-HN97_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.464898
BE-85-CH49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227574
GSE227592_6_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
CB-24-FA25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268644
FARSB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34618
KD-31-TU05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.382877
MCF7_Droxinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163257
POU2F2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSMM	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.968998
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.8021
Rectum adenocarcinoma_READ_TCGA-AH-6897-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4329-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JC-02-ZR15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219208
GSE182680,GSE182683_5_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-62-8402-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BD-04-NG34_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.348522
CTCF_medulloblastoma_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.883287
RC-21-IF98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.324087
Perturb_14187_KD_RUNX1_SRP159178	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.92638
KM-12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.32518
ASTE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.57093
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.636288
Perturb_11523_KD_NR0B1_SRP092641	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.68701
CRCGN015_HEPG2_48H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.65148
GSE82032_3_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-47-BS00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225186
Perturb_5562_KO_MTSS1_SRP266832	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.77223
GSE140997_10_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAL1::TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9545
DD-43-WW40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2729
hsa-miR-98	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
BICR 78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.833955
regulation of macrophage chemotaxis	GO Biological Process Annotations 2025	1.0	null
AB-21-VE32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.721609
Procambium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.871
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.50271
CF-65-GU65_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.55129
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5835-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chr22_23943543_A_C_b38	GTEx eQTL 2025	1.0	1.18694
IA-23-DB04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301474
BCAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16641
IA-00-RJ06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236155
AD-02-XI19_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20217
KC-10-GC29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.306624
blood platelet	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SLC45A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11052
NFKB1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE178340_5_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.11591
Ibutamoren	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
Paroxetine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.48
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.014031
GSE153867_6_v_3_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.5564
Perturb_7460_KD_UPF3B_SRP120604	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.58313
JD-47-WR37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.46812
Perturb_7711_KD_Spt6_SRP132004	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.65021
MAFG::NFE2L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5596
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.848246
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.12602
GANAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33688
ZNF679	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06558
SA-31-VB03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.804381
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.37037
hsa-let-7a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
MARCHF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58135
YB-79-DM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238757
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.4435
PGD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14468
MAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6557
HS 839.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.858579
A549_CUDC-101_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176309
molecular_function	GO Molecular Function Annotations 2015	1.0	null
AA-48-XT80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266598
Forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.5021
FB-19-ZG81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.599031
TTI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3255
RA-49-ZB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254596
Bladder Urothelial Carcinoma_BLCA_TCGA-LT-A5Z6-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
4149_INTS4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.547452
TNFRSF12A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19199
AD-45-YB25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.502617
PFDN6	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_509_KO_PAF1_ERP136917	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.38638
KMS28BM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54799
DD-89-MJ03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203374
MTLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.509
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.56402
hsa-miR-4789-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Perturb_7266_OE_OspC1_SRP368098	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.56916
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E1-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216043_7_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14153
SCHEMBL5061501	DeepCoverMOA Drug Mechanisms of Action	1.0	0.95
GSE123943_4_v_5_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
FBLIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13339
AB-63-HD20_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245558
Perturb_3859_KD_DDR2_SRP333146	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.57903
GSE184399_0_v_3_cnot1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-76-HY47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22269
Xylem parenchyma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.944
Perturb_11544_KD_NPM1_SRP175176	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.12631
4908_MCOLN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.584966
Perturb_7878_KD_CPSF3_SRP266190	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.38363
CRCGN015_HEPG2_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.29216
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9961
Perturb_2762_KD_BRG1_SRP077334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.59838
Perturb_6103_OE_WSTF_SRP400122	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.10617
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.49241
Perturb_8038_KO_FOXA2_SRP350523	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.26245
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.7471
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.463833
Perturb_12148_OE_CENPA_ERP125655	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.16175
UB-79-KN96_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.396872
extracellular organelle	GO Cellular Component Annotations 2015	1.0	null
AA-62-HP31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.610625
ZNF90	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65849
DF-75-MR73_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.273434
CRCGN015_HEPG2_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.86142
Perturb_8703_KD_AR_SRP010350	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.5537
CTCF_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AE-85-LR48_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.421741
Perturb_12031_KD_EFEMP1_SRP213615	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.76313
AA-12-VW53_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.403561
PFEIFFER	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05989
membrane-bounded vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
KC-67-HN97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233299
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.824633
LRATD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42282
NE-92-EU87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.537608
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03395
YY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25131
PRKRIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9559
Thioglucosidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.758
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15489_KD_SMARCA4_SRP218853	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.22649
SCRT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36154
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
IFT27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98595
CD-75-QY45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.489324
GB-92-JY12_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216819
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3844
EDEM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36973
GCSAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43574
FE-21-KA32_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209697
ZBTB26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4085
Hak	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.656
MRPS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4796
Perturb_6887_KO_PFDN5_SRP273783	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.08647
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.313154
REST_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J7-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86185
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZNF691	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42096
Perturb_3875_KD_PLK4_SRP333146	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.7064
HB-06-WU12_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226023
Chromosome 22q11.2 deletion syndrome, distal	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.382
liver_d	HPA Tissue Sample Gene Expression Profiles	1.0	1.92353
Perturb_10075_KD_AQR_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.24918
CC-14-WK34_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.480654
BB-31-EB45_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235916
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239569
EC-98-YS67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211791
AA-12-VW53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.32433
Perturb_382_KD_TOP1_SRP295687	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.79716
Prostate adenocarcinoma_PRAD_TCGA-G9-6354-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.38823
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.07898
PMC10199266-mmc2.xlsx-RUNX1-DEGs-Unnamed_1_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_8241_KD_SRSF1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.8132
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AC-40-KV26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236144
GC-67-AH43_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.26476
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.6726
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.41718
CRCGN015_HEPG2_48H:I06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28346
follicle-stimulating hormone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.654
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AL-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MF-04-HB41_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.358608
Perturb_6777_KD_BRD4_ERP024018	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.40598
GSE85880,GSE85881_4_v_1_tretinoin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-F2-6880-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.00072
ELF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85758
VA-48-TW80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.255229
RSC1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86179
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.9184
extracellular vesicular exosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
IF-87-AU84_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.546468
GABPA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.84193
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.9107
Perturb_8488_KO_GOLPH3_SRP401813	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	18.0315
IA-35-KC86_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.476671
QE-11-DP47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228932
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318474
AB-97-BI36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291025
LB-03-WL18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246748
BB-41-XE67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.01587
Blood plasma	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_6621_KO_NEUROD1_SRP388830	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.39942
CRCGN009_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5787
LE-94-HL75_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260522
AMER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18516
Perturb_13692_KD_NSD2_SRP064418	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.35693
TUB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55289
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OE-34-NH10_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.274131
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.918767
SD-15-WR01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254365
IE-34-IW27_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264584
Lung adenocarcinoma_LUAD_TCGA-86-8674-01A-21R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SB-01A-21R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7242_KD_CNOT1_SRP285534	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.67228
CRCGN015_MCF10A_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.6734
GSE227698_2_v_4_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
FA-12-QB17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299809
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9306
PMC12178829-mmc4.xlsx-Sheet_4-MEG3-KD_Up-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
9656_USP39_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.552966
GSE147876,GSE147877_4_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-63-OW35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.849576
BD-33-HT38_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251829
Myosin VII complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.193
GSE147876,GSE147877_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-72-RI24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286176
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Acute Myeloid Leukemia_LAML_TCGA-AB-2977-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
orbital frontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.52962
NECAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23095
RE-44-GR79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.312745
978_C14ORF178_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.605755
AIFM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54051
TNKS1BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67954
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.40565
MCF7_Enzastaurin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161577
GSE169205_3_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JE-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AD-51-LE62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217827
Perturb_8096_KD_SRSF5_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.43066
Perturb_8769_KD_SERPINA1_SRP302345	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.4378
GSE183335,GSE183351_3_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-62-8397-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BA-68-FJ41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.474343
chr22_23989253_A_T_b38	GTEx eQTL 2025	1.0	1.73312
intramolecular oxidoreductase activity, interconverting keto- and enol-groups	GO Molecular Function Annotations 2025	1.0	null
BA-44-WG29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.432834
GSE211128_3_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.433081
AD-99-SN88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.485783
Perturb_3603_KO_ARID1A_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.48629
cytoplasm	GO Cellular Component Annotations 2015	1.0	null
CE-45-AD14_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.354921
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8722
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256413
TBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8972
MHC class II protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.57
RC-52-AC88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.419279
NCIH650	CCLE Cell Line Gene CNV Profiles	1.0	1.46414
BD-18-MM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.399785
DA-07-LL18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.823744
Eggshell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.853
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.23943
hsa-miR-510	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
9172_TONSL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.506663
DOR 13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.33906
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15155
Premonocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.547
NCIH2286	CCLE Cell Line Gene CNV Profiles	1.0	2.03072
WC-59-RG09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242029
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.635265
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2303
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.574171
Perturb_4910_OE_NR5A1_SRP111466	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Perturb_2552_KD_TRIM28_SRP067706	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.76886
CE-18-ZM38_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.357377
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
H3-4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73527
ZNF221	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38987
OA-86-XP09_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213303
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.43398
KAT2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5365
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_2300_KD_BRCA1_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.84623
Perturb_14155_KO_KBTBD4_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	18.9208
TDRD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.9205
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
1840_CPSF2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.68268
YB-58-IZ37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.417208
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.78382
VU0152100	DeepCoverMOA Drug Mechanisms of Action	1.0	0.22
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A116-11A-12R-A26B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6TW-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SD-51-LL22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.414029
GB-16-SU72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218002
DSTYK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23083
STK155799	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
USF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9672_Mut_NR1H4_SRP115904	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.5773
AC-05-MR83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.276765
BF-10-IO69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238087
STAT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8356
Perturb_8656_OE_ESRRG_SRP304240	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.791
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AZI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3671
Perturb_7762_KD_IER3_SRP348787	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.64012
AC-75-LR63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330507
Skin - Sun Exposed (Lower leg)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.17087
OC-71-BZ81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.476734
Rarg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	107.749
CTCF_GM13977_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.975508
GSE143782_3_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
UF-98-OM26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224047
GSE158834_10_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DA-18-QP05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.315392
AF-33-AM86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.322912
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5UM-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE147876,GSE147877_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.348627
PHLDA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23461
Adventitious root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.524
GSE195568_1_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_15499_Mut_ZMYND11_ERP110742	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.34171
QF-71-QI30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.376043
Perturb_668_KO_CX_SRP212091	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.44502
AC-30-XU83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.770593
GSE216043_10_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.37946
BTF3L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22774
Perturb_12662_KD_KPC1_SRP071659	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.24516
KMT2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31571
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JE-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C12orf29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86576
GSE135350_3_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WA-45-ZD47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.657776
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44198
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CASD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29688
CC-93-RP38_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250174
ATP1A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05511
GSE224742_0_v_1_slc1a5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-75-5146-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DA-17-YW85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.485339
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.5953
GB-31-HY20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237867
AB-21-MV93_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.461666
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.39723
AE-51-ZO26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.354617
DE-90-RU43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217834
extracellular region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE129241_4_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.45215
Prostate adenocarcinoma_PRAD_TCGA-KK-A59Y-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.55435
Perturb_7925_KD_ZCCHC8_SRP222099	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.64458
SIN3A	ENCODE Transcription Factor Targets	1.0	null
ARAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21914
NOB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.08746
hsa-let-7e	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Perturb_14746_OE_MEOX2_SRP330486	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.21632
HES5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4704
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5611
Perturb_2154_KD_SPRY1_ERP114848	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.81236
GSE236502_2_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
QGP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.965105
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.20119
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.914787
GSE131649_4_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09435
Rhox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.8032
GSE134375_3_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE165308_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
7833_SF3A2_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.624994
Perturb_6757_KO|KD_UPF3A/UPF3B|UPF2_SRP327782	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.48095
BD-46-RY02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301248
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fallopian tube	GTEx Tissue Gene Expression Profiles	-1.0	-1.86423
ZNF610	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	75.4065
A549_S-Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160964
CE-69-FD64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261876
TUBA4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4928
Perturb_9986_KD_U2AF2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.71404
VA-06-DB75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.897367
CRCGN016_MCF10A.TP53.M_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.79418
A549_Disulfiram_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141607
NCIH1793	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46869
GSE254649_3_v_0_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
cerebellar cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15533
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.20491
USF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
8680_TANGO6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.553461
AA-62-OC45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.253803
ZNF324	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93555
Perturb_13918_OE_PPARGC1A_SRP265351	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
4931_MED11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.40532
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
DB-11-SS01_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220416
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.548499
Perturb_9968_KD_UPF1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.5273
KC-71-KK26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.381005
FD-88-CF51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.397068
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H3-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-532-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
Perturb_11565_KD_BAX/BAK_SRP348085	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
PMC11528209-cd-23-1212_supplementary_table_s7_suppst7.xlsx-A549_EML4_KD_DEGs-List_of_DEGs_of_EML4-knockdown_vs_control_A549_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ARHGAP11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50784
SRGAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67528
NE-92-EU87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.696104
OC-71-BZ81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.456427
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_14021_OE_MIR722_SRP185837	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
CRCGN017_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.19315
Perturb_3596_KO_DELE1_SRP218218	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.52612
molt4	HPA Cell Line Gene Expression Profiles	-1.0	-0.946094
GSE158834_1_v_3_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.4286
D-dopachrome decarboxylase activity	GO Molecular Function Annotations 2025	1.0	null
COL1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82122
ED-22-QV85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.309942
YF-00-IN39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.24104
NCI-H446	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.864551
ZNF593	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84645
Perturb_2533_KO_HSF1_SRP341615	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.88161
BC-36-PL31_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.645247
AE-39-DG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.20694
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A85H-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H2AC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8066
NFYA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4118
6515_POLD1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.555409
TCF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.7465
PRR7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96009
dorsal thalamus_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07239
GSE199538,GSE199539_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC38	CCLE Cell Line Gene CNV Profiles	1.0	1.45758
TNFAIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47572
MRPS30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50904
Perturb_14085_KD_GAS41_SRP110132	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.7262
internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
SC-17-WW78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.353537
chr22_23989394_T_C_b38	GTEx eQTL 2025	1.0	1.04235
Lung adenocarcinoma_LUAD_TCGA-44-A47A-01A-21R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RD-57-WQ44_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.319932
regulation of tumor necrosis factor production	GO Biological Process Annotations 2025	1.0	null
LE-81-PG11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.415307
DC-43-KF54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.623015
ABCF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58469
STX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44238
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54732
BC-75-CK91_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268513
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MD-86-UW46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.296559
SPTY2D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65854
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.01541
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-37-LS05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.525682
BD-32-GI59_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.312192
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PC-87-OG75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.443388
MCM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05066
pc3	HPA Cell Line Gene Expression Profiles	1.0	0.948304
A549_Flavopiridol HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133148
CRCGN017_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.01272
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.306955
CRCGN015_MCF10A_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.45805
USF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NPDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87887
IRF4_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3880_KD_UBR4_SRP333146	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.62231
WC-33-YP46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.306663
STK368746	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
TBC1D3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56375
MCF7_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160892
GSE158834_7_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12412
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.312634
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
XB-75-YN01_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223511
DE-28-XP50_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203992
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.874607
ED-91-LY45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.452186
DNER	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74973
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-PN-A8MA-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BC-15-EL49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.449116
OD-39-RY38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237454
AD-66-NV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.328304
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33953
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258815
hsa-miR-3173-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Crizotinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.83
GD-46-BU97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273803
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.999156
dorsolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.958321
FF-96-HL81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.344126
Perturb_2518_KD_ZNF414_SRP269946	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.86604
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.15638
GSE48812_2_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-47-MP58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.480997
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06924
imidazoleglycerol-phosphate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.072
ZFP36L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.28271
organism form	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
EE-32-EY37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.591811
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6753
ZBTB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.6947
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.91063
BE-36-XE09_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.365833
hsa-miR-1827	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
CRCGN015_HEPG2_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5338
Metanephron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.62
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-L3-A524-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
regulation of ERK1 and ERK2 cascade	GO Biological Process Annotations 2025	1.0	null
blood plasma	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SIX5	ENCODE Transcription Factor Targets	1.0	null
OE-78-XD40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.331918
ficolin-1-rich granule lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.509
SE-76-JI27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20848
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9447
extracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
BD-38-QC39_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.546317
TC-25-NY68_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206753
Walking leg	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.689
Tautomerase/MIF superfamily	InterPro Predicted Protein Domain Annotations	1.0	null
Perturb_9668_Mut_NR1H4_SRP115904	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.3958
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
8271_SON_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.505575
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CC-20-ZO24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208016
CTCF_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_11349_KD_NFAT1_SRP173011	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.908319
MAF-26560356-CHIP-SEQ-TH2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
AA-47-MP58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244245
Kidney Chromophobe_KICH_TCGA-KN-8433-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.7158
thalamus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN015_MCF10A.TP53.M_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.55445
KB-92-MK13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239799
GA-28-SS67_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.522736
CF-22-IS33_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.319826
RFX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94713
GSE213715_0_v_1_iqgap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
6548_POLR2G_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.612745
BD-83-QC82_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245061
LNCAP	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.879667
Perturb_14287_KD_TENT4A_SRP237261	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.30771
primary motor-sensory cortex (samples)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.47052
Perturb_9281_KO_HNRNPUL1_SRP374878	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.85214
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rotigotine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
GSE218727_0_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
9837_WDR70_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.573543
MD-09-FE75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.513754
NC-52-AG88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.706837
LD-47-RN92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.637353
MCF7_CYC116_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134366
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00174
8594_SUPT16H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.509855
CE-69-HJ13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.7743
JD-58-MV19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.516833
OSBPL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65349
Intrinsic component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.964
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
EIF1AD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.13206
PSMA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60098
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JL-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.21
Perturb_3887_KD_EIF2B5_SRP124930	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.3858
LB-65-SM65_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.494726
GSE160765_2_v_1_twist1_human	RummaGEO Gene Perturbation Signatures	1.0	null
OA-62-NJ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.417049
NCI-H2085	COSMIC Cell Line Gene CNV Profiles	1.0	2.11167
Perturb_2352_KD_CTBP1_SRP072302	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.82573
QF-00-NO42_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264489
TMEM181	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12445
GC-67-AH43_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.333338
Perturb_8993_OE_LIMA1_ERP128082	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.40909
Perturb_6732_KO|KD_UPF3B|UPF1_SRP327782	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.43462
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.834899
GSE158834_0_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ID-30-ST90_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.491856
CHEMBL569227	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
Umbilical artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.791
Sigmoid_Colon	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.07132
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KC-32-GO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.81978
CRCGN015_HEPG2_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.38005
SAP130	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74503
PGR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9119
BE-76-XL76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.420903
AC-86-KF37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.685237
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDT1-MF-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.478
Axillary bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.859
A549_WHI-P154_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158523
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.6069
Sarcoma_SARC_TCGA-JV-A75J-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14093_KD_HDAC1_SRP199194	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.49517
hsa-miR-4662a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.88027
Perturb_6618_KO_NEUROD1_SRP388830	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.93413
ZNF852	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84741
SP1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14391_KD_PAX8_SRP276625	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-17.8069
EF-75-JG46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.339377
PA-53-BA36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.279035
free-living state	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.61
GSE213228_1_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.986
ICAM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28791
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.545525
TTYH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64705
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258863
HT-144	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.18042
hsa-miR-4685-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23166
Fruit capsule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.0
FOXL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87254
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.550054
LSG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25088
FE-21-KA82_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.577359
Perturb_7502_KD_PHF12_SRP194754	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.16202
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19987
GSE158834_1_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CD83	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81274
primary motor cortex (area M1, area 4)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01693
LGI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39423
KS1	CCLE Cell Line Gene CNV Profiles	1.0	1.62437
Perturb_7456_KO_DHX36_SRP120501	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.51798
BC-36-PL31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.386675
Lung squamous cell carcinoma_LUSC_TCGA-21-1075-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPEGNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08787
Brain Lower Grade Glioma_LGG_TCGA-DU-5872-02A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GSE131649_2_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LHFPL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12934
EC-62-NP61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.433821
HCC1534	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.64461
Perturb_12362_KD_SNRPB_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.78991
HELQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14634
NB-24-VE53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216763
Prostate adenocarcinoma_PRAD_TCGA-YL-A8HO-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VC-19-YG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201816
3872_HNRNPL_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.637049
QA-07-KC40_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228882
LY2584702	DeepCoverMOA Drug Mechanisms of Action	1.0	0.31
SCRT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7701
AA-68-OJ16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.11237
Perturb_7388_KO|KD_UPF3B|UPF3A_ERP130413	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
NCI-H2461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20331
Perturb_7367_KD_H2BC21_SRP308810	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.46069
SP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
small intestine	GTEx Tissue Gene Expression Profiles	1.0	1.20133
HB-13-XB94_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.432279
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.49633
FD-15-HD09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200208
455_ARGLU1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.608087
N4BP2L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89074
LA-57-ZX71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.582859
FC-85-OX77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.29123
OB-06-WW76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.453305
hsa-miR-4518	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
AK-54059	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
CC-90-FE70_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265058
Perturb_2546_KD_EZH2_SRP067706	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.1845
AA-10-VR76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.412499
XRN2-22483619-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_3262_KO_VHL_SRP337931	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.908
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147876,GSE147877_4_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YA-85-VH07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.304438
HOXC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43858
MCF7_Cediranib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191862
vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.51569
CB-13-ZM26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.502596
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
GSE158834_1_v_9_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_7_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.38955
Perturb_8716_KO_DHRS4AS1_SRP370273	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.62616
FLII	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52414
PAQR7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.277
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.418446
FOXA2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3869_HNRNPK_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.544327
KMS-21BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14891
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9934_KD_AKAP8L_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.13531
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.15835
KD-86-AJ75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226019
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9963_KD_MTPAP_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.72845
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3041
GSE232624_4_v_5_ethanol_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLC35E3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3758
CRCGN015_MCF10A_48H:B13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12398
HA-03-TL98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208036
chr22_23944815_G_T_b38	GTEx eQTL 2025	1.0	1.25393
DCBLD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.02665
LHX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16263
BB-57-NT83_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202114
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S14-Table_S14_MR_resluts_of_brain_pQTL_and_cardioembolic_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
CAMKMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7891
BB-57-NT83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245366
RPL30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38296
Perturb_7281_OE_UPF3A_ERP130416	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.26341
GSE198982,GSE198986_1_v_2_daunorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265188
EVSAT	CCLE Cell Line Gene CNV Profiles	1.0	1.56255
JE-61-XN48_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.16427
BE-57-VZ17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.379798
NR2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.1797
RCOR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73592
6708_PPWD1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.532308
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273312
ZNF684	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.6009
CRCGN014_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7206
Perturb_15381_KD_FGF13_SRP319157	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.37609
AD-85-ME82_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270608
GSE229973_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
POMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42073
hsa-miR-4764-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
BD-93-AM31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.368383
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DC-99-NQ50_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201876
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.2356
AD-66-NO48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.64918
AC-24-QG69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20658
CRCGN017_MCF10A.TP53.M_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6641
PC-63-CH43_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211879
hsa-let-7g	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00174
Perturb_12253_KO|KD_SDHB|SDHA_SRP128515	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.6788
DD-49-YG96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.378817
CCNB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06717
Liver hepatocellular carcinoma_LIHC_TCGA-EP-A3RK-11A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AA-99-PN83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.48463
SLCO4A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9602
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15155
ZC-47-HL31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.291693
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A7WI-01A-12R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CORO6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73135
CA-39-ZJ18_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.333695
MF-41-QM60_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.403021
Lung adenocarcinoma_LUAD_TCGA-73-4670-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GA-51-DD14_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257113
Albumen gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.66
GSE226355,GSE226357_1_v_0_ybx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PB-09-OE00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.439446
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3698
BC-76-HY47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286651
SA-32-CC58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241328
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2349_KD_PBRM1_SRP381930	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.83286
intramolecular oxidoreductase activity, interconverting keto- and enol-groups	GO Molecular Function Annotations 2023	1.0	null
AB-53-AW00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.38567
TD-48-XJ84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262891
QB-42-MC63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259907
ZNF148	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	127.018
HNF4A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.0645
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07274
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.32463
KMS-26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.53738
KD-04-TL80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203966
GB-73-QS80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.351959
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
924_BTF3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.522415
EIF4A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62838
978_C14ORF178_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.09751
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JB-48-AO57_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.307851
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.936092
AC-57-ZF49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209201
COLO 678	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.942793
RELA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1111
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9909
CIP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30734
AD-86-OB87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213328
AW-16-2259_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235285
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
HFM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70783
SLC16A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09233
hsa-miR-4731-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.612028
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2145
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AC-40-KV26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221736
Lung adenocarcinoma_LUAD_TCGA-75-7031-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.4578
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.451871
AIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48833
FDXR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78136
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE140997_4_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
MIER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.80476
Pancreatic adenocarcinoma_PAAD_TCGA-LB-A8F3-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Merocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.535
EXOSC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18961
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22161
3086_FIP1L1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.735776
Perturb_2803_KO_CDH1_SRP267080	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.75019
BB-43-YQ76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230217
KDM5D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33294
GSE118077_7_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
PC-63-CH43_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.438705
SAP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02174
HA-81-VN33_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.55524
Perturb_3655_KO_MTHFD1_SRP120974	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
MYL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7942
343_ANKRD52_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.514417
KLHL24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49418
Perturb_3873_KD_OR10A5_SRP333146	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.98533
MD-09-FE75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.657323
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.925613
SP5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	88.3554
TCF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.9414
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A148-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Melanotic neurilemmoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.591
LD-36-DG33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247034
Agammaglobulinemia 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.904
CF-15-FD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.620764
DE-46-NH51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203235
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.991597
MD-86-UW46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.446576
Perturb_39_KD_ATRX_SRP308220	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.43152
H2AC15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41908
KC-36-DK23_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.611152
DNM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18047
Brain - Amygdala	GTEx Tissue Gene Expression Profiles 2023	1.0	1.19749
BHLHE40_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180392
Perturb_8736_KD_SREBF1_SRP169608	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.16621
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45083
CDK12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60087
IB-56-JN40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.426061
hsa-miR-4475	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
CC-03-PW00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.53869
IA-38-XE73_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.341705
Perturb_7950_KO_BAZ1A_SRP100570	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.01459
FD-59-TC81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.490366
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
FA-47-IB34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.395898
EC-96-OH91_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.339459
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
FKBP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65829
CRCGN012_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8115
PABPC1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.64871
AA-62-HP31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.842442
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.862762
PPIP5K2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44327
BB-43-YQ76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.316392
CBFA2T3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.58171
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1471
SUPT3H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95663
HF-33-KS15_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.500595
ZNF417	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5255
Lung squamous cell carcinoma_LUSC_TCGA-85-A53L-01A-21R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26087
Nr1h3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.8006
LHX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96605
Perturb_3870_KD_MYH7_SRP333146	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.63299
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25607
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MJ-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.945146
GSE190384,GSE190386_0_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
AP1S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20651
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BA-15-VE07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.363223
MCF7_ENMD-2076 L-Tartaric acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187511
Perturb_8226_KD_EWSR1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.6731
TE-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.11167
GTF2E2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58853
Perturb_12945_KD_METTL3_SRP106608	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.64594
MD-09-FE75_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.759156
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.483267
KLHL18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42486
GB1	CCLE Cell Line Gene CNV Profiles	1.0	1.79841
3872_HNRNPL_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.29467
TEAD4	ENCODE Transcription Factor Targets	1.0	null
GSE147876,GSE147877_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Asarone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.7
MHC protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.957
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.25882
NCI-H226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.03363
GE-40-GQ38_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243234
BD-23-MT28_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234965
CE-35-LA42_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.537578
Sensorimotor area	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.74
ED-91-LY45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.798649
SDR42E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28626
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7H7-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BB-58-LW82_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.308634
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_y_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2333
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VA-06-DB75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.522829
Perturb_11530_KD_THOR_SRP121007	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
VA-48-RJ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.320245
CRCGN008_HEPG2_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35715
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-4A-A93X-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IA-03-BO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.355477
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.64803
CC-90-EX35_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.47611
NKX2-8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.79801
Rectum adenocarcinoma_READ_TCGA-EI-6883-01A-31R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE168602,GSE168604_2_v_6_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-eTable_38_Cis-instrument_Mendelian_randomizaion_screen_of_1_901_cortical_proteins_on_lifetime_smoking_behavior_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
EF-82-OV15_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301268
CRCGN016_MCF10A.TP53.M_24H:P11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.68818
F12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67726
Perturb_10058_KD_UCHL5_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.9232
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.70506
OA-73-DX11_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269537
ED-83-GF49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260238
DF-00-BX35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.607925
DE-58-OW37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236809
S0-EE-YAXR_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.02579
A549_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172085
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.284477
KC-10-GC29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213936
BC-13-OQ01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235891
CF-24-KQ98_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.349732
UF-14-LK87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203092
CLIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07159
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.596433
FGFR1OP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84381
LF-14-KL05_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222788
Urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
1464_CDYL_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.521338
CRCGN017_MCF10A.WT.HP_24H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4216
JUND_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOSL2	ENCODE Transcription Factor Targets	1.0	null
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BT-483	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.77417
TTC19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.50221
Perturb_13867_KD_KDM6B_SRP258989	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.8347
ARTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01491
OXSM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65849
KA-75-LP02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.274854
DB-33-HZ87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.457268
S0-EE-Y7IR_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.676078
LTN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19775
GSE125014_6_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OB-61-XZ91_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.674201
AD-58-PW17_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224777
Perturb_3748_KD_NORAD_SRP149071	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.09141
PLEKHF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.94414
IF-78-GO12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.504639
AC-95-NR38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.319031
Cardiovascular Diseases	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE160001,GSE160670_3_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KB-17-DU74_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.432181
GSE211128_2_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NFX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91138
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16016
MA-58-RR04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201167
Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.8823
PPTC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48881
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UI-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
brockmann body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.97042
Perturb_14898_KO_H14_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.19134
2203_DHX15_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.655198
GSE210662_3_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_3721_KD_DNMT1_SRP049370	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.803
8621_SYMPK_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.581481
GSE130246_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-60-DR81_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.28008
GSE139455_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-17-YW85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.551905
GSE158834_10_v_9_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
XE-69-AT35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.5813
Lung adenocarcinoma_LUAD_TCGA-50-5931-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
excretory gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
17192395-TableS2b	GeneSigDB Published Gene Signatures	1.0	null
GSE202434,GSE202438_2_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_14320_KD_CD95L_SRP111532	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.02585
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211062
Perturb_12363_KD_SNRPE_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.85941
AE-21-BF25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25848
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9934
SK-MEL-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39406
FEN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47126
GSE147876,GSE147877_4_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.513873
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE195559_8_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
C4orf3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.61582
PB-05-XP37_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.538341
CRCGN015_MCF10A.WT.HP_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.38161
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4870-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A71A-01A-22R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_2315_KD_MED9_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.53952
DA-19-JA87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.302339
FA-14-WC79_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302762
6845_PSMA5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.779114
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3559
DF-93-BT88_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.513092
UC-38-AA43_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244445
Mycolate outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.755
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.89599
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.571029
RBCK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36761
MAP3K21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.64453
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
DF-56-GR45_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209058
hsa-miR-1911	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
CREB3L4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.7982
CTCF_MCF-7_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.47364
PC-87-OG75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.470962
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE148262,GSE150691_1_v_2_hdlbp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130246_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OE-34-NH10_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231149
ZNF180	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81829
Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C3A	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68206
skeletal system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
AKIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51251
YB-79-DM48_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257122
HCC1187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.211
CNOT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.585
5-R-Rivaroxaban	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
negative regulation of macrophage chemotaxis	GO Biological Process Annotations 2025	1.0	null
HB-36-FN80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225645
GSE111247_2_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DE-60-SD92_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.372877
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.49816
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M7-01A-12R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.352598
Perturb_14152_KO_KBTBD4_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	18.6778
CRCGN016_MCF10A.TP53.M_24H:D02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.57782
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H2228	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.982939
XB-35-TO54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.379021
10020_ZC3H13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.520487
Perturb_7854_KD_CCNF/E2F7/E2F8_SRP212181	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.78408
PPM1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36129
MD-91-JM80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.313003
UROtsa cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.99
ZNF567	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.42462
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.5
HF-35-HT37_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.47201
HF-35-HT37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.31734
CRCGN015_MCF10A.WT.HP_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04238
IRF4_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIX5_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67X-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MINDY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.09419
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.53738